avaliação da resistência insulínica na síndrome de turner ...
avaliação da resistência insulínica na síndrome de turner ... avaliação da resistência insulínica na síndrome de turner ...
53. Matthews D, Hosker JP, Rudenski AS, Naylor BA, Trecher DF, Turner RC. Homeostasis model assessment: Insulin resistance and b-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 1985; 28:412-9. 54. Katz A, Nambi SS, Mather K. Quantitative Insulin Sensitivity Check Index (QUICKI): A simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85:2402-10. 55. Chen H, Sullivan G, Quon MJ. Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model. Diabetes 2005; 54:1914-25. 56. DeFronzo R, Tobin J, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237:214-23. 57. American Diabetes Association. Conference development on insulin resistance. Diabetes Care 1998; 21:310-4. 58. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000; 23:57-63. 59. Rizza RA, Cryer PE, Gerich JE. Role of glucagon, cathecolamines, and growth hormone in human glucose counterregulation. Effects of somatostatin and combined alfa and beta-adrenergic blockade on plasma glucose recovery and glucose flux rates after insulin-induced hypoglycemia. J Clin Invest 1979; 64:591. 60. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciatori V, et al. Estimates of in vivo insulin action in man: Comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 1989; 68:374-8. 61. Nielsen J, Johansen K, Yde H. The frequency of diabetes mellitus in patients with Turner’s syndrome and pure gonadal dysgenesis: blood glucose, plasma insulin and growth hormone level during an oral glucose tolerance test. Acta Endocrinol Copenh 1969; 62:251–269. 62 62
62. Rasio E, Antaki A, Van Campenhout J: Diabetes mellitus in gonadal dysgenesis: studies of insulin and growth hormone secretion. Eur J Clin Invest 1976; 6:59–66. 63. Polychronakos C, Letarte J, Collu R, Ducharme JR. Carbohydrate intolerance in children and adolescents with Turner syndrome. J Pediatr 1980; 96:1009–1014. 64. Stoppoloni G, Prisco F, Alfano C, Iafusco D, Marrazzo G, Paolisso G. Characteristics of insulin resistance in Turner syndrome. Di abete Metab 1990; 16:267–271. 65. Caprio S, Boulware S, Diamond M, Sherwin RS, Carpenter TO, Rubin K, et al. Insulin resistance: an early metabolic defect of Turner ’s syndrome. J Clin Endocrinol Metab 1991; 72:832–836. 66. Caprio S, Boulware SD, Press M, Sherwin RS, Rubin K, Carpenter TO, et al. Effect of growth hormone treatment on hyperinsulinemia associated with Turner syndrome. J Pediatr 1992; 120:238–243. 67. Gravholt CH, Juul S, Naeraa RW, Hansen J. Morbidity in Turner syndrome. J Clin Epidemiol 1998; 51:147–158. 68. Salgin B, Amin R, Yuen K, Williams RM, Murgatroyd P, Dunger DB. Insulin resistance is an intrinsic defect independent of fat mass in women with Turner's syndrome. Horm Res. 2006; 65:69-75. 69. Hansen I, Tsalikian E, Beaufrere B, et al. Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action. Am J Physiol 1986; 250:269–273. 70. Bratusch-Marrain PR, Smith D, Defronzo RA. The effect of growth hormone on glucose metabolism and insulin secretion in man. J Clin Endocrinol Metab 1982; 55:973–982 71. Rizza RA, Mandarino LJ, Gerich JE. Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes 1982; 31:663–669. 72. Bailey CJ, Ahmed Sorour H. Role of ovarian hormones in the long-term control of glucose homeostasis. Effects of insulin secretion. Diabetologia 1980; 19:475-81. 63 63
- Page 11 and 12: LISTA DE SIGLAS E ABREVIATURAS AMP
- Page 13 and 14: Tabela 14 - Análise descritiva das
- Page 15 and 16: 1 - INTRODUÇÃO A síndrome de Tur
- Page 17 and 18: gonadal é suficientemente grave pa
- Page 19 and 20: 2.2 - Resistência Insulínica - As
- Page 21 and 22: Acredita-se que o HOMA seja uma alt
- Page 23 and 24: 2.3 - Resistência Insulínica na s
- Page 25 and 26: 2.4 - Baixo Peso ao Nascer e Altera
- Page 27 and 28: Gale e cols. avaliaram homens e mul
- Page 29 and 30: 4 - PACIENTES E MÉTODOS 4.1 - Casu
- Page 31 and 32: As pacientes foram submetidas a pun
- Page 33 and 34: 3.3.2 para análise dos dados. O cr
- Page 35 and 36: A média do peso ao nascer na casu
- Page 37 and 38: 5.2 - Avaliação do perfil clínic
- Page 39 and 40: 5.3 - Avaliação do perfil clínic
- Page 41 and 42: 5.4 - Avaliação do perfil laborat
- Page 43 and 44: 65 272 p=0,0002 Figura 3 - Valores
- Page 45 and 46: Tabela 12 - Análise estatística d
- Page 47 and 48: =0,127; p=0,39 Figura 4 - Dispersã
- Page 49 and 50: Percentil 90 2,33 HOMA-IR Figura 6
- Page 51 and 52: 43 o mosaicismo poderia justificar
- Page 53 and 54: de uso de GH nestas pacientes (9 no
- Page 55 and 56: adequado. A etiopatogenia da RI na
- Page 57 and 58: 8 - REFERÊNCIAS 1. Chromosome abno
- Page 59 and 60: 20. Manuel M, Katayama PK, Jones HW
- Page 61: 43. Cesaretti ML, Kohlmann Junior O
- Page 65 and 66: 85. Ibanez L, Jimenez R, de Zegher
- Page 67: metabolism, circulating adipokines,
53. Matthews D, Hosker JP, Ru<strong>de</strong>nski AS, Naylor BA, Trecher DF, Turner RC.<br />
Homeostasis mo<strong>de</strong>l assessment: Insulin resistance and b-cell function from fasting<br />
plasma glucose and insulin concentration in man. Diabetologia 1985; 28:412-9.<br />
54. Katz A, Nambi SS, Mather K. Quantitative Insulin Sensitivity Check In<strong>de</strong>x (QUICKI):<br />
A simple, accurate method for assessing insulin sensitivity in humans. J Clin<br />
Endocrinol Metab 2000; 85:2402-10.<br />
55. Chen H, Sullivan G, Quon MJ. Assessing the predictive accuracy of QUICKI as a<br />
surrogate in<strong>de</strong>x for insulin sensitivity using a calibration mo<strong>de</strong>l. Diabetes 2005;<br />
54:1914-25.<br />
56. DeFronzo R, Tobin J, Andres R. Glucose clamp technique: A method for quantifying<br />
insulin secretion and resistance. Am J Physiol 1979; 237:214-23.<br />
57. American Diabetes Association. Conference <strong>de</strong>velopment on insulin resistance.<br />
Diabetes Care 1998; 21:310-4.<br />
58. Bonora E, Targher G, Alberiche M, Bo<strong>na</strong>don<strong>na</strong> RC, Saggiani F, Zenere MB, et al.<br />
Homeostasis mo<strong>de</strong>l assessment closely mirrors the glucose clamp technique in the<br />
assessment of insulin sensitivity. Diabetes Care 2000; 23:57-63.<br />
59. Rizza RA, Cryer PE, Gerich JE. Role of glucagon, cathecolamines, and growth<br />
hormone in human glucose counterregulation. Effects of somatostatin and combined<br />
alfa and beta-adrenergic blocka<strong>de</strong> on plasma glucose recovery and glucose flux<br />
rates after insulin-induced hypoglycemia. J Clin Invest 1979; 64:591.<br />
60. Bonora E, Moghetti P, Zanca<strong>na</strong>ro C, Cigolini M, Quere<strong>na</strong> M, Cacciatori V, et al.<br />
Estimates of in vivo insulin action in man: Comparison of insulin tolerance tests with<br />
euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab<br />
1989; 68:374-8.<br />
61. Nielsen J, Johansen K, Y<strong>de</strong> H. The frequency of diabetes mellitus in patients with<br />
Turner’s syndrome and pure go<strong>na</strong><strong>da</strong>l dysgenesis: blood glucose, plasma insulin<br />
and growth hormone level during an oral glucose tolerance test. Acta Endocrinol<br />
Copenh 1969; 62:251–269.<br />
62<br />
62
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