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LE BARS, D.; GOZARIU, M.; CADDEN, S.. Animal models of nociception. Pharmacol. Rev. v. 53, p. 597-652, 2001. LEE, S.H.; KAYSER, V.; DESMEULES, J.; GUILBAUD, G.. Differential action of morphine and various opioid agonists on thermal allodynia and hyperalgesia in mononeuropathic rats. Pain. v. 57, n. 2, p. 233-240, 1994. LEE, Y.-J.; ZACHRISSON, O.; TONGE, D.A.; MACNAUGTON, P.A.. Upregulation of bradykinin B2 receptor expression by neurotrophic factors and nerve injury in mouse sensory neurons. Mol. Cell. Neurosci. v. 19, p. 186-200, 2002. LEEB-LUNDBERG, L.M.; MARCEAU, F.; MÜLLER-ESTERL, W.; PETTIBONE, D.J.; ZURAW, B.L.. International Union of Pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol. Rev. v. 57, n. 1, p. 27-77, 2005. LEIBROCK, J.; LOTTSPEICH, F.; HOHN, A.; HOFER, M.; HENGERER, B.; MASIAKOWSKI, P.; THOENEN, H.; BARDE, Y.A.. Molecular cloning and expression of brain derived neurotrophic factor. Nature. v. 341, p. 149-152, 1989. LEVINE, J.D.; FIELDS, H.L.; BASBAUM, A.I. Peptides and the primary afferent nociceptor. J. Neurosci. v. 13, p. 2273-2286, 1993. LEVI-MONTALCINI,R.. The nerve growth factor: thirty-five years later. EMBO J. v. 6, p. 1145-1154, 1987. LEVY, D. e ZOCHODNE, D.W.. Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. v. 86, p. 265-271, 2000. LI, L.; XIAN, C.J.; ZHONG, J.H.; ZHOU, X.F.. Lumbar 5 ventral root transaction-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain. Mol. Cell. Neurosci. v. 23, p. 232-250, 2003. LIN, L.F.. Glial cell line-derived neurotrophic factor (GDNF): a comprehensive review. Neural Notes. v. 2, p. 3-7, 1996. LINDENLAUB, T.; TEUTEBERG, P.; HARTUNG, T.; SOMMER, C.. Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury. Brain Res. v. 866, p. 15-22, 2000.
LOESER, J.D.. Pain and suffering. Clin. J. Pain. v. 16, p. S2-S6, 2000. LOESER, J.D.. What's to be done? Comments on Grabow et al. Clin. J. Pain. v. 19, n. 6, p. 384, 2003. LOESER, J.D. e BLACK, R.G.. A taxonomy of pain. Pain. v. 1, p. 81-84, 1975. LOESER, J.D. e MELZACK, R.. Pain: an overview. Lancet., v. 353, p. 1607-1609, 1999. LOMBARD, M.C.; NASHOLD J.R., B.S.; ALBE-FESSARD, N.; SALMAN, C.; SAKR, N.. Deafferentation hypersensitivity in the rat after dorsal rhizotomy: a possible animal model of chronic pain. Pain. v. 6, p. 163–174, 1979. MA, Q.P. e WOOLF, C.J.. The progressive tactile hyperalgesia induced by peripheral inflammation in nerve growth factor dependent. NeuroReport. v. 8, p. 807-810, 1997. MA, Q.-P.; HILL, R.; SIRINATHSINGHJI, D.. Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat. NeuroReport. v. 18, p. 4003-4005, 2000. MACEWAN, D.J.. TNF receptor subtype signalling: differences and cellular consequences. Cell Signal. v. 14, p. 477-492, 2002. MACFARLANE, B.V.; WRIGHT, A.; O´CALLAGHAN, J.; BENSON, H.A.. Chronic neuropathic pain and its control by drugs. Pharmacol. Ther. v. 75, p. 1-19, 1997. MACHADO, A.. Neuroanatomia funcional. Atheneu: São Paulo, p. 112-113, 2000. MADEDDU, P.; VARONI, M.V.; PALOMA, D.; EMANUELI, C.; DEMONSTIS, M.P.; GLORIOSO, N.; DESSI-FULGHERI, P.; SARZANI, R.; ANANIA, V.. Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene. Circulation. v. 96, p. 3570-3578, 1997. MAGERL, W.; FUCHS, P.N.; MEYER, R.A.; TREEDE, R.D.. Roles of capsaicininsensitive nociceptors in cutaneous pain and secondary hyperalgesia. Brain. v. 124, n. Pt 9, p. 1754-1764, 2001. MALIK-HALL, M.; DINA, O.A.; LEVINE, J.D.. Primary afferent nociceptor mechanisms mediating NGF-induced mechanical hyperalgesia. Eur. J. Neurosci. v. 21, p. 3387- 3394, 2005.
Page 1 and 2:
NARA LINS MEIRA QUINTÃO ANÁLISE D
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Depois de algum tempo você.... ...
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Às minhas amigas Ali, Beth, Gica,
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hipernociceptivas induzidas pela AP
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LISTA DE ABREVIAÇÕES aa Aminoáci
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TBE Tris/borato/EDTA TNFα Fator de
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Figura 18 - Efeito dos anticorpos c
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RESUMO A avulsão do plexo braquial
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ABSTRACT Brachial plexus avulsion (
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através das vias sensoriais e, a n
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podendo persistir até mesmo após
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de estímulo e, após sensibilizaç
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Figura 1. Vias envolvidas na dor ne
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dos efeitos antidepressivos, pois e
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técnicas modernas de farmacologia,
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associada à dor neuropática, pouc
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1997). Segundo Wynn Parry (1980), a
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2003). Por outro lado, os fatores n
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“neurotrófico” é aplicada ao
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A neurotrofina NT-3 exerce um papel
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As cininas desempenham seus efeitos
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2. OBJETIVOS 2.1. Objetivo geral Ad
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3. MATERIAL E MÉTODOS 3.1. Animais
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3.3. Análise do limiar mecânico a
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1957). O aparelho de rota-rod (Ugo
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(0,5 µg/sítio) ou i.c.v. (0,5 µg
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anteriormente em diferentes interva
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utilizando os seguintes primers: se
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PBS (todos da Sigma Chemical Compan
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Figura 5 - Hipernocicepção mecân
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4.3. Peso corporal, atividade locom
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4.4. Análise dos diferentes mecani
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4.4.1.2. Efeito do anticorpo anti-T
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4.4.1.3. Efeito do anticorpo anti-T
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Quando os camundongos receberam uma
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Do mesmo modo, a administração po
Page 77 and 78: É válido ressaltar que o tratamen
Page 79 and 80: 4.4.3.1. Efeito do antagonista sele
Page 81 and 82: Figura 22 - Hipernocicepção mecâ
Page 83 and 84: Figura 23 - Efeito de antagonistas
Page 89 and 90: A B Figura 26 - Quantificação do
Page 91 and 92: 5. DISCUSSÃO Por séculos, médico
Page 93 and 94: envolvidas nestes dois tipos de hip
Page 95 and 96: epresentar a solução para a compr
Page 97 and 98: Como se pode observar no presente e
Page 99 and 100: Recentemente, estas proteínas têm
Page 101 and 102: mediadores (tais como BK e SP), é
Page 103 and 104: induzidas pela APB, embora seu envo
Page 105 and 106: Após axotomia, os neurônios corti
Page 107 and 108: densidade moderada de sítios de li
Page 109 and 110: Pesquero e colaboradores (2000) des
Page 111 and 112: lot, confirmam a hipótese do envol
Page 113 and 114: eduzindo o limiar do reflexo nocice
Page 115 and 116: Figura 28. Proposta para os possív
Page 117 and 118: APFEL, S.C.; WRIGHT, D.E.; WIIDEMAN
Page 119 and 120: BOUCHER, T.J.; OKUSE, K.; BENNETT,
Page 121 and 122: the brain is increased during persi
Page 123 and 124: FERREIRA, J.; BEIRITH, A.; MORI, M.
Page 125 and 126: GUIMARÃES, J.A.; BORGES, B.R.; PRA
Page 127: JOHNSON, D.; LANAHAN, A.; BUCK, C.R
Page 131 and 132: their central terminations within t
Page 133 and 134: POO, M.. Neurotrophins as synaptic
Page 135 and 136: SANG, C.N.. NMDA-receptor antagonis
Page 137 and 138: SOMMER, C.; PETRAUSCH, S.; LINDENLA
Page 139 and 140: WALL, P.D.; SCADDING, J.W.; TOMKIEW
Page 141 and 142: 7. ANEXOS
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