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HEFTI, F.F.; ROSENTHAL, A.; WALICKE, P.A.; WYATT, S.; VERGARA, G.; SHELTON, D.L.; DAVIES, A.M.. Novel class of pain drugs based on antagonism of NGF. Trends Pharmacol. Sci. v. 27, n. 2, p. 85-91, 2005. HELLMICH, H.L.; KOS, L.; CHO, E.S.; MAHON, K.A.; ZIMMER, A.. Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interaction. Mec. Develop. v. 54, p. 95-105, 1996. HENDERSON, C.E.; PHILLIPS, H.S.; POLLOCK, R.A.; DAVIES, A.M.; LEMEULLE, C.; ARMANINI, M.; SIMMONS, L.; MOFFET, B.; VANDLEN, R.A.; SIMPSON, L.C.. GDNF: a potent survival factor for moto-neurons present in peripheral nerve and muscle. Science. v. 266, p. 1062-1064, 1994. HEUMANN, R.; KORSCHING, S.; BANDTLOW, C.; THOENEN, H.. Changes of nerve growth factor synthesis in noneuronal cells in response to sciatic nerve transection. J. Cell. Biol. v. 104, p. 1623-1631, 1987. HOANE, M.R.; GULWADI, A.G.; MORRISON, S.; HOVANESIAN, G.; LINDNER, M.D.; TAO, W.. Differential in vivo effects of neurturin and glial cell line-derived neurotrophic factor. Exp. Neurol. v. 160, p. 235-243, 1999. HOKE, A.; CHENG, C.; ZOCHODNE, D.W.. Expression of glial cell-derived neurotrophic factor family of growth factors in peripheral nerve injury in rats. NeuroReport. v. 11, p. 1651-1654, 2000. HYLDEN, J.L. e WILCOX, G.L.. Intrathecal morphine in mice: a new technique. Eur. J. Pharmacol. v. 67, p. 313-316, 1980. IGNATOWSKI, T.A.; COVEY, W.C.; KNIGHT, P.R.; SEVERIN, C.M.; NICKOLA, T.J.; SPENGLER, R.N. Brain-derived TNFα mediates neuropathic pain. Brain Res. v. 84, p. 70-77, 1999. ILSE, W.K.. Neuropathic pain: Mechanisms, diagnosis and treatment. Can. J. Continuing Med. Education. v. 14, p. 99-108, 2002. JENSEN, T.S. e BARON, R.. Translation of symptoms and signs into mechanisms in Neuropathic pain. Pain. v. 102, p. 1-8, 2003. JENSEN, T.S.; GOTTRUP, H.; SINDRUP, S.H.; BACH, FLEMMING, W.B.. The clinical picture of Neuropathic pain. Eur. J. Pharmacol. v. 429, p. 1-11, 2001.
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Page 1 and 2:
NARA LINS MEIRA QUINTÃO ANÁLISE D
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Depois de algum tempo você.... ...
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Às minhas amigas Ali, Beth, Gica,
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hipernociceptivas induzidas pela AP
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LISTA DE ABREVIAÇÕES aa Aminoáci
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TBE Tris/borato/EDTA TNFα Fator de
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Figura 18 - Efeito dos anticorpos c
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RESUMO A avulsão do plexo braquial
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ABSTRACT Brachial plexus avulsion (
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através das vias sensoriais e, a n
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podendo persistir até mesmo após
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de estímulo e, após sensibilizaç
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Figura 1. Vias envolvidas na dor ne
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dos efeitos antidepressivos, pois e
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técnicas modernas de farmacologia,
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associada à dor neuropática, pouc
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1997). Segundo Wynn Parry (1980), a
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2003). Por outro lado, os fatores n
Page 37 and 38:
“neurotrófico” é aplicada ao
Page 39 and 40:
A neurotrofina NT-3 exerce um papel
Page 41 and 42:
As cininas desempenham seus efeitos
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2. OBJETIVOS 2.1. Objetivo geral Ad
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3. MATERIAL E MÉTODOS 3.1. Animais
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3.3. Análise do limiar mecânico a
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1957). O aparelho de rota-rod (Ugo
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(0,5 µg/sítio) ou i.c.v. (0,5 µg
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anteriormente em diferentes interva
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utilizando os seguintes primers: se
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PBS (todos da Sigma Chemical Compan
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Figura 5 - Hipernocicepção mecân
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4.3. Peso corporal, atividade locom
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4.4. Análise dos diferentes mecani
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4.4.1.2. Efeito do anticorpo anti-T
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4.4.1.3. Efeito do anticorpo anti-T
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Page 71 and 72:
Page 73 and 74:
Quando os camundongos receberam uma
Page 75 and 76: Do mesmo modo, a administração po
Page 77 and 78: É válido ressaltar que o tratamen
Page 79 and 80: 4.4.3.1. Efeito do antagonista sele
Page 81 and 82: Figura 22 - Hipernocicepção mecâ
Page 83 and 84: Figura 23 - Efeito de antagonistas
Page 89 and 90: A B Figura 26 - Quantificação do
Page 91 and 92: 5. DISCUSSÃO Por séculos, médico
Page 93 and 94: envolvidas nestes dois tipos de hip
Page 95 and 96: epresentar a solução para a compr
Page 97 and 98: Como se pode observar no presente e
Page 99 and 100: Recentemente, estas proteínas têm
Page 101 and 102: mediadores (tais como BK e SP), é
Page 103 and 104: induzidas pela APB, embora seu envo
Page 105 and 106: Após axotomia, os neurônios corti
Page 107 and 108: densidade moderada de sítios de li
Page 109 and 110: Pesquero e colaboradores (2000) des
Page 111 and 112: lot, confirmam a hipótese do envol
Page 113 and 114: eduzindo o limiar do reflexo nocice
Page 115 and 116: Figura 28. Proposta para os possív
Page 117 and 118: APFEL, S.C.; WRIGHT, D.E.; WIIDEMAN
Page 119 and 120: BOUCHER, T.J.; OKUSE, K.; BENNETT,
Page 121 and 122: the brain is increased during persi
Page 123 and 124: FERREIRA, J.; BEIRITH, A.; MORI, M.
Page 125: GUIMARÃES, J.A.; BORGES, B.R.; PRA
Page 129 and 130: LOESER, J.D.. Pain and suffering. C
Page 131 and 132: their central terminations within t
Page 133 and 134: POO, M.. Neurotrophins as synaptic
Page 135 and 136: SANG, C.N.. NMDA-receptor antagonis
Page 137 and 138: SOMMER, C.; PETRAUSCH, S.; LINDENLA
Page 139 and 140: WALL, P.D.; SCADDING, J.W.; TOMKIEW
Page 141 and 142: 7. ANEXOS
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