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GALLUZZI, K.E.. Management of neuropathic pain. JAOA. v. 105, n. 9, p. s12-s19, 2005. GARCIA-MARCH, G.; SANCHEX-LEDESMA, M.J.; DIAZ, P.; YAGUE, I.; ANAYA, J.; GONÇALVES, J.; BROSETA, J.. Dorsal root entry zone lesions versus spinal cord stimulation in the management pain from brachial plexus avulsion. Acta Neurochir. v. 39, p.155-158, 1987. GEORGE, A.; MARZINIAK, M.; SCHÄFERS, M.; TOYKA, K.V.; SOMMER, C.. Thalidomide treatment in chronic contrictive neuropathy decreases endoneurial tumor necrosis factor-α, increases interleukine-10 and has long-term effects on spinal cord dorsal horn met-enkephalin. Pain. v. 88, p. 267-275, 2000. GEORGE, A.; BUEHL, A.; SOMMER, C.. Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve. Exp. Neurol. v. 192, p. 163-166, 2005. GIEHL, K.M.; ROHRIG, S.; BONATZ, H.; GUTJAHR, M.; LEINER, B.; BARTKE, I.; YAN, Q.; REICHARDT, L.F.; BACKUS, C.; WELCHER, A.A.; DETHLEFFSEN, K.; MESTRES, P.; MEYER, M.. Endogenous brain-derived neurotrophic factor and neurotrophin-3 antagonistically regulate survival of axotomized corticospinal neurons in vivo. J. Neurosci. v. 21, n. 10, p. 3492-3502, 2001. GORDON, D.B. e LOVE, G.. Phamacologic management of neuropathic pain. Pain Managment Nursing. v. 5, n. 4, p. 19-33, 2004. GOUGAT, J.; FERRARI, B.; SARRAN, L.; PLANCHENAULT, C.; PONCELET, M.; MARUANI, J.; ALONSO, R.; CUDENNEC, A.; CROCI, T.; GUAGNINI, F.; URBAN- SZABO, K.; MARTINOLLE, J.J.; SOUBRIE´, P.; FINANCE, O.; LE FUR, G.. SSR240612 [(2R)-2-[((3R)-3-(1,3-Benzodioxol-5-yl)-3-{[(6-methoxy-2naphthyl)sulfonyl]amino}propanoyl)amino]-3-(4-{[2R,6S)-2,6dimethylpiperidinyl]methyl}phenyl)-N-isopropyl-N-methylpropanamide Hydrochloride], a new nonpeptide antagonist of the bradykinin B1 receptor: biochemical and pharmacological characterization. J. Pharmacol. Exp. Ther. v. 309, p. 661-669, 2004. GRUBB, B.D.. Peripheral and central mechanisms of pain. Br. J. Anaesth. v. 81, n. 1, p. 8-11, 1998.
GUIMARÃES, J.A.; BORGES, B.R.; PRADO, E.S.; PRADO, J.L.. Kinin-converting aminopeptidase from humam serum. Biochem. Pharmacol. v. 22, p. 3157-3172, 1973. GUSTAFSSON, H.; FLOOD, K.; ODD-GEIR, B.; BRODIN, E.; OLGART, L.; STILLER, C-O.. Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. Exp. Neurology. v. 182, p. 427-434, 2003. GWAK, Y.S.; NAM, T.S.; PAIK, K.S.; HULSEBOSCH, C.E.; LEEM, J.W.. Attenuation of mechanical hyperalgesia following spinal cord injury by administration of antibodies to nerve growth factor in the rat. Neurosci. Lett. v. 336, p. 117-120, 2003. HALL, J.M. e MORTON, I.K.M.. The pharmacology and immunopharmacology of kinin receptors. In: FARMER, S.G. The handbook of immunopharmacology: The kinin system. Academic Press: London, p. 9-43, 1997. HANDWERKER, H.O. e REEH, P.W.. Algesimetry: a necessity in research on analgesic drugs. Agents Actions Suppl. v. 19, p. 33-49, 1986. HANESCH, U.; PAWLAK, M.; MCDOUGALL, J.J.. Gabapentin reduces the mechanosensitivity of fine afferent nerve fibers in normal and inflamed rat knee joints. Pain. v. 104, p. 363-366, 2003. HANSSON, P.T. e DICKENSON, A.H.. Pharmacological treatment of peripheral neuropathic pain conditions based on shared commonalities despite multiple estiologies. Pain. v. 113, p. 251-254, 2005. HARDEN, N. e COHEN, M.. Unmet needs in the management of neuropathic pain. J. Pain Symptom Management. v. 25, p. 12-17, 2003. HARGREAVES, K.; DUBNER, R.; BROWN, F.; FLORES, C.; JORIS, J.. A new and sensitive method for measuring thermal nociception in cutaneous hiperalgesia. Pain. v.32, p.77-88, 1988. HATTORI, K.; HIRANO, T.; MIYAJIMA, H.; YAMAKAWA, N.; TATENO, M.; OSHIMI, K.; KAYAGAKI, N.; YAGITA, H.; OKUMURA, K.. Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologies. Blood. v. 91, p. 4051-4055, 1998.
Page 1 and 2:
NARA LINS MEIRA QUINTÃO ANÁLISE D
Page 3 and 4:
Depois de algum tempo você.... ...
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Às minhas amigas Ali, Beth, Gica,
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hipernociceptivas induzidas pela AP
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LISTA DE ABREVIAÇÕES aa Aminoáci
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TBE Tris/borato/EDTA TNFα Fator de
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Figura 18 - Efeito dos anticorpos c
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RESUMO A avulsão do plexo braquial
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ABSTRACT Brachial plexus avulsion (
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através das vias sensoriais e, a n
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podendo persistir até mesmo após
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de estímulo e, após sensibilizaç
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Figura 1. Vias envolvidas na dor ne
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dos efeitos antidepressivos, pois e
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técnicas modernas de farmacologia,
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associada à dor neuropática, pouc
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1997). Segundo Wynn Parry (1980), a
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2003). Por outro lado, os fatores n
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“neurotrófico” é aplicada ao
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A neurotrofina NT-3 exerce um papel
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As cininas desempenham seus efeitos
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2. OBJETIVOS 2.1. Objetivo geral Ad
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3. MATERIAL E MÉTODOS 3.1. Animais
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3.3. Análise do limiar mecânico a
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1957). O aparelho de rota-rod (Ugo
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(0,5 µg/sítio) ou i.c.v. (0,5 µg
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anteriormente em diferentes interva
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utilizando os seguintes primers: se
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PBS (todos da Sigma Chemical Compan
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Figura 5 - Hipernocicepção mecân
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4.3. Peso corporal, atividade locom
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4.4. Análise dos diferentes mecani
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4.4.1.2. Efeito do anticorpo anti-T
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4.4.1.3. Efeito do anticorpo anti-T
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Page 71 and 72:
Page 73 and 74: Quando os camundongos receberam uma
Page 75 and 76: Do mesmo modo, a administração po
Page 77 and 78: É válido ressaltar que o tratamen
Page 79 and 80: 4.4.3.1. Efeito do antagonista sele
Page 81 and 82: Figura 22 - Hipernocicepção mecâ
Page 83 and 84: Figura 23 - Efeito de antagonistas
Page 89 and 90: A B Figura 26 - Quantificação do
Page 91 and 92: 5. DISCUSSÃO Por séculos, médico
Page 93 and 94: envolvidas nestes dois tipos de hip
Page 95 and 96: epresentar a solução para a compr
Page 97 and 98: Como se pode observar no presente e
Page 99 and 100: Recentemente, estas proteínas têm
Page 101 and 102: mediadores (tais como BK e SP), é
Page 103 and 104: induzidas pela APB, embora seu envo
Page 105 and 106: Após axotomia, os neurônios corti
Page 107 and 108: densidade moderada de sítios de li
Page 109 and 110: Pesquero e colaboradores (2000) des
Page 111 and 112: lot, confirmam a hipótese do envol
Page 113 and 114: eduzindo o limiar do reflexo nocice
Page 115 and 116: Figura 28. Proposta para os possív
Page 117 and 118: APFEL, S.C.; WRIGHT, D.E.; WIIDEMAN
Page 119 and 120: BOUCHER, T.J.; OKUSE, K.; BENNETT,
Page 121 and 122: the brain is increased during persi
Page 123: FERREIRA, J.; BEIRITH, A.; MORI, M.
Page 127 and 128: JOHNSON, D.; LANAHAN, A.; BUCK, C.R
Page 129 and 130: LOESER, J.D.. Pain and suffering. C
Page 131 and 132: their central terminations within t
Page 133 and 134: POO, M.. Neurotrophins as synaptic
Page 135 and 136: SANG, C.N.. NMDA-receptor antagonis
Page 137 and 138: SOMMER, C.; PETRAUSCH, S.; LINDENLA
Page 139 and 140: WALL, P.D.; SCADDING, J.W.; TOMKIEW
Page 141 and 142: 7. ANEXOS
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