carcinoma papilífero familiar de tireóide - Faculdade de Medicina ...

FAMILIAL PAPILLARY CARCINOMA OF THE THYROID: ASSESSMENT OF
ITS PREVALENCE AND ASSOCIATED FUNCTIONAL, MORPHOLOGICAL AND
AUTOIMMUNE ABNORMALITIES.
Elaine Maria dos Santos Gomes
Orientador: Prof. Alexandru Buescu
Abstract da Dissertação de Mestrado submetida ao Programa de Pós-
graduação em Endocrinologia, da Universidade Federal do Rio de Janeiro – UFRJ,
como parte dos requisitos necessários à obtenção do título de Mestre em
Endocrinologia.
Papillary carcinoma is the most common type of non-medullary thyroid
cancer and its familial form has been increasingly reported with an estimated
prevalence of about 5%.This study’s objectives were: to evaluate the prevalence of
papillary carcinoma among the first degree relatives of patients with this tumor;
verify the existence of any relationship with thyroid dysfunction or autoimmunity
and the prevalence of thyroid structural abnormalities.A transverse study was
performed with the inclusion of 143 first degree relatives of 52 patients followed for
papillary carcinoma of the thyroid in the outpatient clinic of the HUCFF ( average of
2.75 relatives per index case). Serum TSH, free T4 and TPOAb were determined
and thyroid ultrasonography (US) was performed. Any nodule larger than 1 cm and
all smaller but suspicious nodules were sent to FNAB. Malignant or suspicious
cytologies were indication for surgery. Of the patients harboring the familial form of
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