bei der Herzinsuffizienz
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Ryanodin-Kanal Remodeling<br />
<strong>bei</strong> <strong>der</strong> <strong>Herzinsuffizienz</strong><br />
Normal<br />
RyR2<br />
FKBP12.6<br />
SR<br />
DIASTOLE<br />
HF<br />
+<br />
JTV519<br />
(S107)<br />
Ser 2809<br />
Ca 2+ -Leak<br />
P P<br />
RyR2<br />
SR<br />
Ser 2815<br />
CaMKII<br />
FKBP12.6<br />
Wehrens et al., Science 2004;304:292; Lehnart et al., PNAS 2006;103:7906: Ai et al., Circ Res 2005;97:1314.
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