bei der Herzinsuffizienz
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Fokale (ektope) Aktivität <strong>bei</strong> <strong>der</strong> <strong>Herzinsuffizienz</strong><br />
I Ca,L<br />
Ca 2+<br />
NCX<br />
Ser 2814<br />
(CaMKII)<br />
P<br />
P<br />
Ser 2808<br />
(PKA)<br />
?<br />
RyR2<br />
Ca 2+<br />
I NCX<br />
?<br />
DADs<br />
SR<br />
RyR2<br />
Ca 2+ Ca 2+<br />
Ca 2+ Ca 2+<br />
Ca 2+ Load<br />
Ca 2+ Ca 2+<br />
Ca 2+<br />
PLN<br />
Serca2<br />
P<br />
Ca 2+<br />
Ca 2+<br />
CSQ<br />
Ca 2+<br />
CSQ = Calsequestrin<br />
Ca 2+ Ca 2+ Ca 2+<br />
Sarcoplasmic reticulum<br />
Pogwizd, Circ Res 2000;87:641; Marx et al., Cell 2000;101:365; Lindner et al., JMCC 30;743;<br />
Ai et al., Circ Res 2005;97:1314; Pogwizd & Bers, Trends Cardiovasc Med 2004;14:61.
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