POSTOPERATIEVE PIJNBEHANDELINGAANHANGSEL – POSTOPERATIEVE MISSELIJKHEID EN BRAKEN (POMB)AanbevelingenVoor de behandeling van POMB worden metoclopramide en 5-HT3-antagonisten geadviseerd.Metoclopramide is het minst effectief. Gebalanceerde anti-emetische therapie is het meesteffectief.N.B.: metoclopramide niet toepassen bij kinderen onder de 30kg.17. Fujii Y, Saitoh Y, Tanaka H, Toyooka H. Prophylactic oral antiemetics for preventing postoperative nausea and vomiting:granisetron versus domperidone. Anesth Analg 1998;87(6):1404-7.18. Paech MJ, Pavy TJ, Kristensen JH, Wojnar-Horton RE. Postoperative nausea and vomiting: development of amanagement protocol. Anaesth Intensive Care 1998;26(2):152-5.Het invoeren van een protocol <strong>voor</strong> POMB, zowel profylactisch als therapeutisch, wordt aangeraden.Een stappenplan <strong>voor</strong> de toediening van de medicatie is hierbij nodig.Literatuur1. Royal College of Anaesthetists. Raising the standard. London: The Royal College;2000.2. Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs 2000;59:213-43.3. Bountra C, Gale JD, Gardner CJ, Jordan CC, Kilpatrick GJ, Twissel DJ, et al. Towards understanding the aetiologyand pathophysiology of the emetic reflex: novel approaches to antiemetic drugs. Oncology 1996;53(suppl 1):102-9.4. Pueyo FJ, Carrascosa F, Lopez L, Iribarren MJ, Garcia-Pedrajas F, Saez A. Combination of ondansetron and droperidolin the prophylaxis of postoperative nausea and vomiting. Anesth Analg 1996;83:117-22.5. Rose JB, Watcha MF. Postoperative nausea and vomiting in paediatric patients. Br J Anaesth 1999;83:104-17.6. Henzi I, Walder B, Tramer MR. Dexamethasone for the prevention of postoperative nausea and vomiting: a quantativesystematic review. Anesth Analg 2000;90:186-94.7. Domino KB, Anderzon EA, Polissar NL, Posner LL. Comparative efficacy and safety of ondansetron, droperidol andmetoclopramide for preventing postoperative nausea and vomiting: a meta-analysis. Anaesth Analg 1999;88:1370-9.8. Sinclair DR, Chung F, Mezei G. Can postoperative nausea and vomiting be predicted? Anesthesiology 1999;91:109-18.9. Tramer MR, Moore RA, Reynolds DJ, McQuay HJ. A quantitative systematic review of ondansetron in treatment ofestablished postoperative nausea and vomiting. BMJ 1997;12;314(7087):1088-92.10. Henzi I, Walder B, Tramer MR. Metoclopramide in the prevention of postoperative nausea and vomiting: a quantitativesystematic review of randomized, placebo-controlled studies. Brit J Anaesthesia 1999;83:761-71.11. Janknegt R, Helmers H, Meijler WJ, Pinckaers JWM, Brouwers JRBJ. 5-HT3 receptor antagonists in the prophylaxis ofpostoperative nausea and vomiting . Drug selection by means of the soja method. Ned Tijdschr Anesth 2000;13:51-6.12. Tang J, Wang B, White PF, Watcha MF, Qi J, Wender RH. The effect of timing of ondansetron administration on itsefficacy, cost-effectiveness and cost-benefit as a prophylactic antiemetic in the ambulatory setting. Anesth Analg1998;86:274-82.13. Sung Y-F. Risks and benefits of drugs used in the management of postoperative nausea and vomiting. Drug Safety1996;14:181-97.14. Tramer MR. A rational approach to the control of postoperative nausea and vomiting: evidence from systematicreviews. Part II. Recommendations for prevention and treatment, and research agenda. Acta Anaesthesiol Scand2001;45(1):14-9.15. Tramer MR. A rational approach to the control of postoperative nausea and vomiting: evidence from systematicreviews. Part I. Efficacy and harm of antiemetic interventions, and methodological issues. Acta Anaesthesiol Scand2001;45(1):4-13.16. Stienstra R, Samhan YM, El-Mofty M, Bout LEA de, Bovill JG. Double-blind comparison of alizapride, droperidoland ondansetron in the treatment of post-operative nausea. Eur J Anaesthsiol 1997;14:290-4.162163
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