NTOG 2010 10

372
10
Nederlands tijdschrift voor Obstetrie & Gynaecologie vol. 123, december 2010
2006,3:CD004454.
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perinatal outcomes. NIH Consens Statement
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4. Been JV, Kramer BW, Zimmermann LJ. Antenatal
corticosteroids to prevent preterm birth. Lancet
2009;373:894.
5. Goldenberg RL, Andrews WW, Faye-Petersen OM,
Cliver SP, Goepfert AR, Hauth JC. The Alabama
Samenvatting
Toediening van antenatale steroïden bij dreigende
vroeggeboorte behoort tot de dagelijkse praktijk.
Er bestaat echter weinig duidelijkheid omtrent de
veiligheid en effectiviteit van deze behandeling bij
verdenking op een intra-uteriene infectie (chorioamnionitis).
In een survey onder Nederlandse perinatologen
blijken de meningen en praktijkvoering
ten aanzien van deze kwestie sterk uiteen te lopen.
De meerderheid van de deelnemers vindt een gerandomiseerde
trial zinvol.
Trefwoorden
chorioamnionitis, vroeggeboorte, antenatale steroiden,
survey
Summary
Administration of antenatal steroids is common
practice in immient preterm delivery. However,
there is debate concerning the safety and efficacy
of antenatal steroids when intrauterine infection/
inflammation (chorioamnionitis) is suspected. A nationwide
survey was performed among Dutch perinatologists
to explore their opinions on the use of
antenatal steroids in preterm delivery with suspected
chorioamnionitis. There was great diversity in
perinatologists’ opinions on the safety and efficacy
of antenatal steroids in preterm labour with clinical
chorioamnionitis. The majority feel that there
is lack of evidence on the subject and favour a randomised
clinical trial addressing the issue.
Keywords
chorioamnionitis, preterm birth, antenatal steroids,
survey
preterm birth study: corticosteroids and neonatal
outcomes in 23- to 32-week newborns with various
markers of intrauterine infection. Am J Obstet
Gynecol 2006;195:1020-4.
6. Been JV, Rours IG, Kornelisse RF, et al. Histologic
chorioamnionitis, fetal involvement, and antenatal
steroids: effects on neonatal outcome in preterm
infants. Am J Obstet Gynecol 2009;201:587.e1-8.
7. Been JV, Degraeuwe PL, Kramer BW, Zimmermann
LJ. Antenatal steroids and neonatal
outcome after chorioamnionitis: a meta-analysis.
BJOG 2010 Nov 4 [Epub ahead of print].
8. Sweet DG, Huggett MT, Warner JA, et al. Maternal
betamethasone and chorioamnionitis induce
different collagenases during lung maturation in
fetal sheep. Neonatology 2008;94:79-86.
Gemelde (financiële) belangenverstrengeling
geen
Auteurs
Drs. S. Lievense MSc, student arts-klinisch onderzoeker,
afdeling Kindergeneeskunde en School
for Oncology and Developmental Biology (GROW),
Maastricht Universitair Medisch Centrum
Dr. B.W. Kramer, kinderarts-neonatoloog, afdeling
Kindergeneeskunde en School for Oncology and
Developmental Biology (GROW), Maastricht Universitair
Medisch Centrum
Prof. dr. L.J.I. Zimmermann, kinderarts-neonatoloog,
afdeling Kindergeneeskunde en School for
Oncology and Developmental Biology (GROW),
Maastricht Universitair Medisch Centrum
Prof. dr. J.G. Nijhuis, gynaecoloog-perinatoloog,
afdeling Obstetrie en Gynaecologie en School for
Oncology and Developmental Biology (GROW),
Maastricht Universitair Medisch Centrum
Dr. J.V. Been, kinderarts in opleiding, afdeling Kindergeneeskunde
en School for Public Health and
Primary Care (CAPHRI), Maastricht Universitair Medisch
Centrum
Correspondentieadres
Jasper V. Been
Maastricht Universitair Medisch Centrum
Afdeling Kindergeneeskunde
Postbus 5800
6202 AZ Maastricht
Telefoon: 043-3876543
E-mail: jasper.been@mumc.nl