blok 7 bloed en bloedvormende organen - VETserieus
blok 7 bloed en bloedvormende organen - VETserieus
blok 7 bloed en bloedvormende organen - VETserieus
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WHO classification K9 malignant lymphoma<br />
. G<strong>en</strong>eralized<br />
. Alim<strong>en</strong>tary<br />
. Thymic<br />
. Skin<br />
. Leukemic (true)<br />
. Other (including solitary r<strong>en</strong>al)<br />
Clinical Symptoms dep<strong>en</strong>d on:<br />
• Enlargem<strong>en</strong>ts of organs involved<br />
• Dysfunction of organs involved<br />
Clinical Symptoms<br />
. Lymphad<strong>en</strong>opathy (painless) . Dyspnea . Lymph node/thymus . liquothorax . Abdominal <strong>en</strong>largem<strong>en</strong>t .<br />
Liver, sple<strong>en</strong> . Ascites . T<strong>en</strong>esmus . Fatigue . Weight loss<br />
. Fever . Vomiting, diarrhea . Polyuria/polydipsia . Anemia . Coagulopathy . Neural signs/blindness . Skin<br />
lesions<br />
Diagnosis I<br />
. Hematologic abnormalities<br />
. Leucocyte/lymphocyte count<br />
. Pres<strong>en</strong>ce of pathological lymphocytes<br />
. Biochemistry<br />
. Hypercalcemia<br />
. Monoclonal gammapathy<br />
. Ultrasound<br />
. Endoscopy<br />
. X-ray<br />
. (Histology)<br />
. Fine needle aspiration biopsy + Cytology<br />
Stage<br />
1 One lymph node / lymphoid organ<br />
2 >1 lymph nodes in 1 region (± tonsils)<br />
3 More lymph nodes in more than 1 region<br />
4 Liver and/or sple<strong>en</strong><br />
5 Blood and bone marrow/other organs<br />
a. Without systemic signs<br />
b. With systemic signs<br />
Verder: • Architecture: diffuse nodular/follicular<br />
• Cell type: State of maturation<br />
Treatm<strong>en</strong>t of multic<strong>en</strong>tric lymphoma I<br />
1) Surgery (Stage I disease?; spl<strong>en</strong>ectomy?)<br />
2) Hormonal<br />
* Corticosteroids:<br />
- CR-rates 17-43%<br />
- mean remission times 1-2 months
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