ÍÄ×ÒÏËÏÂÉÀ - DNT Union
ÍÄ×ÒÏËÏÂÉÀ - DNT Union
ÍÄ×ÒÏËÏÂÉÀ - DNT Union
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amiloidis daSla<br />
rogorc zemoT iyo aRniSnuli, glikoproteini SAP yvela tipis amiloidis<br />
universaluri Semadgeneli komponentia. es nivTiereba gamoirCeva<br />
rezistentulobiT proteolizis mimarT da Sesabamisad misi kavSiri amiloidur<br />
fibrilebTan icavs am ukanasknelT fagocituri ujredebisa da proteulizuri<br />
fermentebis mier degradaciisagan. SAP–isa da fibrilis Soris kavSiris<br />
darRveva amiloidozis mkurnalobis perspeqtiul strategias warmoadgens.<br />
am mizniT Seqmnili nivTiereba CPHPC amJamad klinikuri kvlevis stadiaSia.<br />
amiloidozis mkurnalobis mimzidveli strategiaa imunoTerapia, rac<br />
gulisxmobs amiloidis sawinaaRmdego antisxeulebis gamoyenebiT amiloiduri<br />
depozitebis daSlas. ukve Seqmnilia erT-erTi aseTi antisxeuli da<br />
mosalodnelia misi klinikuri Seswavlis dawyeba AL amiloidoziT daavadebul<br />
pacientebSi. imunoTerapia yvelaze ukeT Seswavlilia alcheimeris daavadebis<br />
SemTxvevaSi, sadac muSavdeba β cilis mimarT pasiuri da aqtiuri imunizaciis<br />
strategiebi.<br />
gamoyenebuli literatura:<br />
1. Alex M. davison, J.Stewart Cameron, Jean-Pierre Grunfeld, Claudio Ponticheli, Eberhard Ritz, Cristopher G. Winearls,<br />
Charls van Yaperele. Oxford Textbook of Clinical Nephrology, 2005.<br />
2. Ulrich Kulmann, Dieter Walb, frierich C. Luft. Nephrologie.Pathophysiologie-Klinik-Nierenersatzverfahren. Georg<br />
Thieme Verlag. Stutgard-new York.<br />
3. Drug Insight: emerging therapies for amyloidosis. Julian D Gillmore, Philip N Hawkins. Nature Clinical Practice<br />
Nephrology 2, 263 - 270 (01 May 2006)<br />
4. Dwomoa Adu, Paul Emery and Michael Madaio. Rheumatology and the Kidney. Oxford Univercity Press, 2001.<br />
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