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scienze della vita roma, 22-23 ottobre 2012 - SIF

scienze della vita roma, 22-23 ottobre 2012 - SIF

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9. Cataldi M, Panuccio G, Cavaccini A, D'Antuono M, Taglialatela M, Avoli M. Involvement of inward rectifier<br />

and M-type currents in carbachol-induced epileptiform synchronization. Neuropharmacology. 2011<br />

Mar;60(4):653-61.<br />

10. Martire M, Barrese V, D'Amico M, Iannotti FA, Pizzarelli R, Samengo I, Viggiano D, Ruth P, Cherubini E,<br />

Taglialatela M. Pre-synaptic BK channels selectively control glutamate versus GABA release from cortical<br />

and hippocampal nerve terminals. J Neurochem. 2010 Oct;115(2):411-<strong>22</strong>.<br />

11. D'Amico M, Samengo I, Navarra P, Taglialatela M, Martire M. AMPA- and P2X7-receptor-mediated<br />

facilitation of [3H]D-aspartate release from nerve terminals isolated from the rat caudal brainstem. Neurochem<br />

Int. 2010 Nov;57(6):6<strong>23</strong>-8.<br />

12. Iannotti FA, Panza E, Barrese V, Viggiano D, Soldovieri MV, Taglialatela M. Expression, localization, and<br />

pharmacological role of Kv7 potassium channels in skeletal muscle proliferation, differentiation, and survival<br />

after myotoxic insults. J Pharmacol Exp Ther. 2010 Mar;332(3):811-20.<br />

PROSPETTIVE ED OBIETTIVI PER I PROSSIMI TRE ANNI<br />

Intendiamo definire le correlazioni geneotipo-fenotipo per patologie convulsive associate a mutazioni dei canali Kv7 e<br />

sostanziare ulteriormente come tali proteine di membrana possano fungere da targets molecolari per farmaci ad attività<br />

anticonvulsivante ed antinocicettiva.<br />

COLLABORAZIONI INTERNAZIONALI IN ATTO<br />

Prof. Francisco Bezanilla, University of Chicago (USA)<br />

Prof. Rym Benkhalifa, Pasteur Institute, Tunis (TN)<br />

Prof. Alvaro Villarroel, Unidad de Biofísica CSIC-UPV/EHU, Bilbao (ES)<br />

PRINCIPALI ATTREZZATURE DI CUI DISPONE L’UNITÀ DI RICERCA<br />

3 Set-ups per registrazioni elettrofisiologiche su singola cellula (patch-clamp)<br />

1 FACS-Scanner<br />

1 Biacore per Surface-plasmon resonsance<br />

1 sequenziatore DNA ABI-Prism<br />

1 Microscopio con testata confocale<br />

Diversi termociclatori per PCR<br />

PAROLE CHIAVE<br />

LS5 Neurosciences and neural disorders: neurobiology, neuroanatomy, neurophysiology, neurochemistry,<br />

neuropharmacology, neuroimaging, systems<br />

neuroscience, neurological disorders, psychiatry<br />

LS5_2 Molecular and cellular neuroscience<br />

LS5_5 Mechanisms of pain<br />

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