17. Male Repro. System Lab - Yale Medical Cell Biology
17. Male Repro. System Lab - Yale Medical Cell Biology
17. Male Repro. System Lab - Yale Medical Cell Biology
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Spermatotgenesis and Spermiogenesis
Posterior
Interstitial/Leydig cellsSeminiferous tubulesHuman Testicular Parenchyma46c 2nDNA46c 4nDNA23c 1nDNA23c 2nDNA23c 1nDNAClonal Nature of<strong>Male</strong> Germ <strong>Cell</strong>s
46c 2nDNABasal compartmentAdluminal compartment46c 4nDNA46c 4nDNA23c 2nDNA23c 1nDNAHuman Spermatogenesis23c 1nDNAElongating spermatidsSertoli cell cytoplasmRound spermatidsPrimary spermatocytesSpermatogoniumSeminiferous Tubules
Hormone Stimuli forSpermatogenesisT, testosteroneFSH, follicle stimulatinghormoneSP, primary spermatocyteAdluminal compartmentBasal compartmentBasal/AdluminalCompartmentsSpermatogonia, S; 46c 2nDNAPrimary spermatocyte, S 1; 46c 4nDNASt, Sertoli cellS 4 , Spermatid; 23c 1nDNAAV, developing acrosomal vesicles
Adluminal compartmentSpecial junctional complexbetween Sertoli cells:blood-testis barrierBasal compartmentBlood-Testis BarrierInter-Sertoli <strong>Cell</strong> Occluding Junction
Sertoli <strong>Cell</strong>Adluminal compartmentOccluding junction = blood-testis barrierBasal compartmentSertoli <strong>Cell</strong>
Seminiferous tubulesTunica albugineaTestis: Low MagnificationLumenSZSpSCPSSGSCSGSeminiferous Tubules: SG, spermatogonia; PS, primary spermatocyte;Sp, spermatids; SC, Sertoli cells; SZ, spermatozoa
LymphaticBlood vesselLumenSGPSInterstitial cells/Leydig cellsSZLumenSeminiferousDominant SecondaryTubules: SG, spermatogonia; PS, primary spermatocyte;Follicle (Graffian Follicle)Sp, spermatids; SC, Sertoli cells; SZ, spermatozoaLumenSGPSSZInterstitial cellsSeminiferousDominant SecondaryTubules: SG, spermatogonia; PS, primary spermatocyte;Follicle (Graffian Follicle)Sp, spermatids; SC, Sertoli cells; SZ, spermatozoa
Crystals of ReinkeInterstitial <strong>Cell</strong>sSmooth ERLipid dropletInterstitial <strong>Cell</strong>: EM
Spermiogenesis
Sperm Head: AV = acrosomal vesicle
XS of Sperm Neck: Ax, axoneme of flagellum; Mi, mitochondriaTestis: Spermatozoon, diagram
Rete Testis: SEMExcurrent Ducts
Rete testisSeminiferous tubulesRete TestisCiliated columnarepithelial cellsCuboidal cellsDuctuli Efferentes
Ciliated columnarepithelial cellsCuboidal cellsDuctuli EfferentesSperm in lumenPseudostratified columnarepithelium with stereociliaEpididymis
Sperm in lumenPseudostratified columnarepithelium with stereociliaEpididymisPseudostratified columnarepithelium with stereociliaSperm in lumenEpididymis
Sperm in lumenSperm in lumenPseudostratified columnarepithelium with stereociliaEpididymisSmooth muscle layersPseudostratified columnarepithelium with stereociliaDuctus Deferens
Pseudostratified columnarepithelium with stereociliaSmooth muscle layersDuctus/Vas DeferensPseudostratified columnar epitheliumSmooth muscleSeminal Vesicles
Pseudostratified columnarepithelium; secretorySeminal VesiclesProstate Gland
Heterogeneous epithelium:cuboidal, columnar, pseudostratifiedProstate GlandProstatic concretionProstate Gland
Prostatic concretionProstate GlandUrethraErectile tissueTunica albuguineaHuman Penis XS
Pseudostraified columnar epitheliumErectile tissueHuman UrethraSome Pathology
Normal (L) & Atrophic Testis (R)Interstitial/Leydig cellsNormal Human Testis
Atrophic Human Testis: What cells are left? What reproductive problems might thisman have?Testicular Seminoma/Gross
Testicular Seminoma: Note differences in size between seminoma and normal germ cells.Normal Prostate/Gross
Normal ProstateAdenocarcinoma of the Prostate
Adenocarcinoma of the ProstateMitotic figures
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