rezistentuli tuberkulozi
rezistentuli tuberkulozi rezistentuli tuberkulozi
cxrili #3meore rigis medikamentebi, ZiriTadi kategoriebi, dozebi da gverdiTimovlenebimedikamentebi gverdiTi movlenebi dozaII jgufiaminoglikozidebikanamicini (Km)amikacini (Am)kapreomicini (Cm)kapreomicinis ineqc.BP 2000,kapreomicinis ineqc.USP 24III jgufiftorqinolonebilevofloqxaciniofloqsacini (Ofx)sparfloqsacinimoqsifloqsacinisaineqcio tubsawinaaRmdego medikamentebixSiria:- tkivili ineqciis adgilas- SratSi da SardSi kreatininismomateba, hipokalemia, hipokalcemia,hipomagnezemiaSedarebiT iSviaTia:- ototoqsiuroba, tinitusi, vertigo- Seqcevadi nefrotoqsiuroba- kanis reaqciebi, hepatitixSiria:- nefrotoqsiuroba- hipermgrZnobeloba: dermatiti,cxeleba- azotemia, proteinuriaSedarebiT iSviaTia:- ototoqsiuroba- nervkunTovani mablokirebelimoqmedeba- steriluri abscesi ineqciisadgilasftorqinolonebiZiriTadad aitaneba kargadSedarebiT iSviaTia:- gastrointestinuri darRvevebi- cvlilebebi cns-is mxriv: Tavbrusxveva,Tavis tkivili, mousvenroba, tremori,uZiloba, mxedvelobis darRvevebi,halucinaciebi, fsiqozuri reaqciebi,depresia, konvulsiebi.Zalzed iSviaTia:- periferuli neiropaTia- fsevdomembranuli koliti- hipermgrZnobeloba: dermatiti,anafilaqsia- foto-mgrZnobeloba (sparfloqsacini)- arTralgia, saxsris eroziebi, myesebisdazianeba- SratSi kreatininis gardamavalimomateba,- Tirkmlis mwvave ukmarisoba,- RviZlis fermentebis momateba, hepatiti- eozinofilia, agranulocitozi- 750mg-1000mg/dR.15mg/kg/dR. >50kg an
IV jgufiTionamidebieTionamidi (Eto)proTionamidi (Pto)cikloserini (Cs)an terizidoniklozapinicikloserini,cikloserinis kafs.USP 24,para-aminosalicilismJava (PAS)unda gamoviyenoTmxolod PASERPperoraluri baqteriostatikuritubsawinaaRmdego medikamentebiyvelaze Znelad asatani medikamentebixSiria:- gastrointestinaluri darRvevebi:Rebineba, gaZlierebuli salivacia,anoreqsia, gulisreva, metalis gemopirSi, gogirdismagvari sunis boyini.SedarebiT iSviaTia:- fsiqozuri reaqciebi: halucinaciebi dadepresia, Tavbrusxveva, gabrueba, Tavistkivili, orTostatuli hipotenzia daasTenia.- hipoglikemia- hepatiti- ginekomastia, menstrualuri darRvevebi- impotencia,- akne, hipermgrZnobeloba- alopecia, dermatiti, hipoTiroidizmi- periferuli da optikuri neiropaTia- pellagras msgavsi sindromi- Trombocitopenia, purpuraxSiria:- neirotoqsiuri reaqciebi: Tavbruxveva,metyvelebis moSla, konvulsiebi, Tavistkivili, tremori, insomnia, gonebisdabindva, depresia da qcevis darRveva.SedarebiT iSviaTia:- generalizebuli hipermgrZnobeloba anhepatiti- foliumis mJ. da vit. B12 deficiturianemia, megaloblasturi dasideroblasturi anemia.- suicidi, damokidebulia dozaze.- gamonakliss SemTxvevebSi: gulisukmarisobaxSiria:- darRvevebi kuW-nawlavis mxriv- hipoTireodizmiSedarebiT iSviaTia:- zogadi hipermgrZnobeloba: kanis mxrivcvlilebebi- hipokalemia- anoreqsia, gulisreva, Rebineba dadiskomforti mucelis areSi- xangrZlivi gamoyenebisas didi dozebiTSesaZloa ganviTardes hipoTiroidizmida Ciyvi.- 500mg-1000mg/dR. 10-20 mg/kg. 70kg: 500mg diliT7dRe 500mg mdedReSi 2XautanlobisSemTxvevaSi, nelnelagaizardos250-dan 750 mgmde.me-2miRebaze,SesaZloa 1 X dR.+ forToxliswveni an rZegulisrevisasacileblad.- pediatriaSi: 15-20mg/kg, maqsimum: 750mg/dR.dRiuri doza: 15-20mg/kg/dRcikloserini: 500-100070kg: 500-250/dR,Semdeg 500-500/dR.terizidoni: 600mg/dRor miRebaze,SesaZloa 1 X dReSi.+50mg piridoqsini/250mgCs.pediatr: 10mg/kg/dRdR. doza:150mg/kg/dR10-12 g/dR ormiRebaze + saSualomJavianobis sasmeli(vaSlis, forToxliswveni, iogurti).70kg: 6g 2 X dR.dozis momatebaxdeba nel-nela 7dRis Semdeg.mesame rigis medikamentebi 3zogierTi, ZiriTadad ki in-vitro gamokvlevebis Tanaxmad ammedikamentebs aqvT garkveuli tubsawinaaRmdego moqmedeba, ris gamoc3 Treatment and Prevention of Multidrug-Resistant Tuberculosis. Ivan Bastian and Robert Colebunders. Institute of TropicalMedicine, Antwerp, Belgium. Drugs 1999 Oct; 58(4): 633-661 Part 6. Suggested Alternative Treatments for MDR TB9
- Page 4 and 5: The schools who have or will receiv
- Page 6 and 7: ganisazRvreba: MGIT swrafi meTodiT
- Page 10 and 11: SesaZloa gamoyenebul iqnen MDR-TB p
- Page 12 and 13: pacienti iwyebs gagrZelebis fazas 7
- Page 14 and 15: • am medikamentebis daniSvnisas d
- Page 16 and 17: E da Z mimarT mgrZnobelobis SemTxve
- Page 18 and 19: aseT SemTxvevebSi saukeTesoa samkur
- Page 20 and 21: exmareba eqTans am samuSaos Sesrule
- Page 22 and 23: TionamidebieTionamidi(Eto)proTionam
- Page 24 and 25: amoqsicilini/klavulinismJavaklariTr
IV jgufiTionamidebieTionamidi (Eto)proTionamidi (Pto)cikloserini (Cs)an terizidoniklozapinicikloserini,cikloserinis kafs.USP 24,para-aminosalicilismJava (PAS)unda gamoviyenoTmxolod PASERPperoraluri baqteriostatikuritubsawinaaRmdego medikamentebiyvelaze Znelad asatani medikamentebixSiria:- gastrointestinaluri darRvevebi:Rebineba, gaZlierebuli salivacia,anoreqsia, gulisreva, metalis gemopirSi, gogirdismagvari sunis boyini.SedarebiT iSviaTia:- fsiqozuri reaqciebi: halucinaciebi dadepresia, Tavbrusxveva, gabrueba, Tavistkivili, orTostatuli hipotenzia daasTenia.- hipoglikemia- hepatiti- ginekomastia, menstrualuri darRvevebi- impotencia,- akne, hipermgrZnobeloba- alopecia, dermatiti, hipoTiroidizmi- periferuli da optikuri neiropaTia- pellagras msgavsi sindromi- Trombocitopenia, purpuraxSiria:- neirotoqsiuri reaqciebi: Tavbruxveva,metyvelebis moSla, konvulsiebi, Tavistkivili, tremori, insomnia, gonebisdabindva, depresia da qcevis darRveva.SedarebiT iSviaTia:- generalizebuli hipermgrZnobeloba anhepatiti- foliumis mJ. da vit. B12 deficiturianemia, megaloblasturi dasideroblasturi anemia.- suicidi, damokidebulia dozaze.- gamonakliss SemTxvevebSi: gulisukmarisobaxSiria:- darRvevebi kuW-nawlavis mxriv- hipoTireodizmiSedarebiT iSviaTia:- zogadi hipermgrZnobeloba: kanis mxrivcvlilebebi- hipokalemia- anoreqsia, gulisreva, Rebineba dadiskomforti mucelis areSi- xangrZlivi gamoyenebisas didi dozebiTSesaZloa ganviTardes hipoTiroidizmida Ciyvi.- 500mg-1000mg/dR. 10-20 mg/kg. 70kg: 500mg diliT7dRe 500mg mdedReSi 2XautanlobisSemTxvevaSi, nelnelagaizardos250-dan 750 mgmde.me-2miRebaze,SesaZloa 1 X dR.+ forToxliswveni an rZegulisrevisasacileblad.- pediatriaSi: 15-20mg/kg, maqsimum: 750mg/dR.dRiuri doza: 15-20mg/kg/dRcikloserini: 500-100070kg: 500-250/dR,Semdeg 500-500/dR.terizidoni: 600mg/dRor miRebaze,SesaZloa 1 X dReSi.+50mg piridoqsini/250mgCs.pediatr: 10mg/kg/dRdR. doza:150mg/kg/dR10-12 g/dR ormiRebaze + saSualomJavianobis sasmeli(vaSlis, forToxliswveni, iogurti).70kg: 6g 2 X dR.dozis momatebaxdeba nel-nela 7dRis Semdeg.mesame rigis medikamentebi 3zogierTi, ZiriTadad ki in-vitro gamokvlevebis Tanaxmad ammedikamentebs aqvT garkveuli tubsawinaaRmdego moqmedeba, ris gamoc3 Treatment and Prevention of Multidrug-Resistant Tuberculosis. Ivan Bastian and Robert Colebunders. Institute of TropicalMedicine, Antwerp, Belgium. Drugs 1999 Oct; 58(4): 633-661 Part 6. Suggested Alternative Treatments for MDR TB9
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