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Licopene, fotoprotezione e cura della pelle - Salute per tutti

Licopene, fotoprotezione e cura della pelle - Salute per tutti

Licopene, fotoprotezione e cura della pelle - Salute per tutti

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Volume 13, n. 2, 2010POSTER AIRO 200979Cutaneous reaction prevention with the use of “Neoviderm skinemulsion” in head and neck external beam radiotherapy (EBRT)and <strong>per</strong>io<strong>per</strong>ative-brachytherapy (BRT) for breast cancerA. Cecconi, A. Guido, S. Cammelli, F. Bunkheila, M. Micucci, A. Pepe, E. Barbieri, L. Busutti“Neoviderm emulsione cutanea”nella prevenzione dei danni cutanei da trattamenti radioterapiciIn questo studio condotto presso il Dipartimento di Radioterapia dell’Università di Bologna è stato testatol’effetto radioprotettivo sulla cute di una innovativa emulsione cutanea (Neoviderm – IstitutoGanassini) abitualmente impiegata nelle scottature solari.Dieci pazienti sottoposte a brachiterapia <strong>per</strong>io<strong>per</strong>atoria <strong>per</strong> neoplasia mammaria e venti pazienti sottopostia radioterapia a fasci esteni (EBRT) mediante tecnica ad intensità modulata (IMRT) <strong>per</strong> neoplasie deldistretto cervico-cefalico sono stati sottoposti a trattamento locale mediante applicazione di Neovidermin posologia di due applicazioni al giorno <strong>per</strong> tutta la durata del trattamento radioterapico e una applicazioneal giorno nei sei mesi successivi.Durante lo studio ogni paziente è stato monitorizzato mediante controlli <strong>per</strong>iodici obiettivi relativi allecondizioni cliniche <strong>della</strong> cute irradiata.I risultati qui riportati indicano che Neoviderm riduce l’eritema e la secchezza, preserva l’elasticità edevita l’impiego di corticosteroidi topici sulla cute irradiata.PurposeTo control the appearance of cutaneousreaction (grade of intensity and incidence)during and after EBRT for head and neck cancerand brachytherapy with MammoSite forbreast cancer using an innovative skin emulsionNeoviderm (by Istituto Ganassini).The object was the protective and moisturizingaction, with alginate-betaglucano acidand hyaluronic acid; in fact this emulsionsoothes the skin favoring the physiologicalnormalizing process.Materials and methodsStudy design: in our institute, sinceFebruary, we have evaluated, with a new clinicaltrial of phase II, 10 patients who have beentreated with brachytherapy (MammoSite) forbreast cancer and 20 patients un derwent EBRTwith or without chemotherapy for head andneck cancer. All patients under went this localtreatment with Neoviderm skin emulsion twiceDepartment of Radiotherapy, S. Orsola-Malpighi HospitalUniversity of Bolognaa day during their radiation treatment and oncea day for six months afterwards. The clinicalanalysis was done with objective analysis(Grading RTOG-SOMA LENT) and the use ofphotograph archiving. During this trial we evaluatedfor every patient the su<strong>per</strong>ficial cutaneousdamage, the skin elasticity, the su<strong>per</strong>ficialchanges: hy<strong>per</strong>pigmentation, epilation,skin dryness, telangiectasia.ResultsAll patients treated with Mammosite-BRT were evaluable at day 0, day 7,1-3months after treatment and 4/10 pts wereevaluable at 6 months. Our results in term ofskin toxicity were: at time 0 3 patients wereGr. 0, 6 pts Gr. 1 and 1 pt developed precociousskin toxicity Gr. 2; after 7 days 5patients Gr. 0 and 5 Gr. 1, after 1 month 6patients Gr. 0 and 4 Gr. 1, after 3 months 8patients Gr. 0 and 4 Gr. 1, after 6 months 4/4patients Gr. 0. In all patients we evaluated alow level of atrophy and hy<strong>per</strong>pigmentationafter treatment and we didn’t use the cortico-

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