Working Paper of Public Health Volume 2012 - Azienda Ospedaliera ...

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Azienda Ospedaliera Nazionale“SS. Antonio e Biagio e Cesare Arrigo”Working Paper of Public Healthnr. 15/2012Titolo: Identificazione precoce dell’abuso di alcol: utilizzo dei biomarcatori emergenti indifferenti matrici biologicheAutori: Bianchi V.*, Arfini C.; 1Tipo: Research ReviewsKeywords: abuso alcolico, transferrina carboidrato carente, etilglucuronide, fosfatidiletanolo,esteri etilici degli acidi grassi;AbstractScopo: Questa rassegna illustra alcuni biomarcatori emergenti misurabili in diverse matricibiologiche che possono permettere l’individuazione precoce dell’abuso alcolico;Metodologia: vengono considerati i biomarcatori più attuali transferrina carboidrato carente(CDT), etilglucuronide (EtG), fosfatidiletanolo (PEth) e gli esteri etilici degliacidi grassi (FAEE) e la loro determinazione nelle diverse matrici biologichecosì come è riportato nella più recente letteratura;Risultati: sono descritte alcune situazioni reali ed è suggerita l’interpretazione dei risultati.Conclusioni: la rassegna fornisce suggerimenti e indicazioni per il corretto uso deibiomarcatori descritti alla luce delle conoscenze e delle applicazioni cliniche eforensi.1S.C. LABORATORIO ANALISILaboratorio di Riferimento Regionale di TossicologiaA.O. “ SS Antonio e Biagio e C Arrigo”Tel +39.0131.206214E-mail vbianchi@ospedale.al.it* Autore per la corrispondenza1
Azienda Ospedaliera Nazionale“SS. Antonio e Biagio e Cesare Arrigo”Working Paper of Public Healthnr. 15/2012Title: Early detection of alcohol abuse: the use of emerging biomarkers in differentbiological materials.Authors: Bianchi V.*, Arfini C.; 2Type: Research ReviewsKey words: alcohol abuse, carbohydrate.-deficient transferrin, ethylglucuronide, phosphatidylethanol, fatty acids ethyl estersAbstractAim: This review presents how some emerging biomarkers may allow the early detection ofalcohol abuse when detected in different biological materials;Methodology: carbohydrate-deficient transferrin (CDT), ethylglucuronide (EtG),phosphatidyl ethanol (PEth) and fatty acids ethyl esters (FAEE) are shown asmore recent literature suggests;Results: some real situations are reported as well as the correct interpretation;Conclusion: this review provides advice on the proper use of these emerging biomarkersaccording to the knowledge and clinical and forensic applications.2S.C. LABORATORIO ANALISILaboratorio di Riferimento Regionale di TossicologiaHospital “ SS Antonio e Biagio e C Arrigo”Tel +39.0131.206214E-mail vbianchi@ospedale.al.it* Corresponding author2
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