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Azienda Ospedaliera Nazionale“SS. Antonio e Biagio e Cesare Arrigo”Working Paper of Public Healthnr. 12/2012[140] JR Berenson et al “American Society of Clinical Oncology clinical practice guidelines:the role of bisphosphonates in multiple myeloma”. J Clin Oncol 20(17): pp3719-36, 2002[141] M.Venegoni “Ritorna, coi bifosfonati nuovi, la vecchia necrosi dei fiammiferai”Occhio clinico n. 6, pp 15-16, 2005[142] BG Durie, M Katz, J Crowley.”Osteonecrosis of the jaw and bisphosphonates” N EnglJ Med. 353(1): pp 99-102, 2005 .[143] M Zambelli, M Scoletta, M Mozzati “L’informazione del paziente come elemento diprevenzione della BRONJ” in “Osteonecrosi dei mascellari (ONJ): Prevenzione, Diagnosi,Trattamento. UPDATE 2010”, pp 43, 2010 , available athttp://www.reteoncologica.it/index.php?option=com_content&view=article&id=134&Itemid=854. [144] CA Migliorati, K Mattos, MJ Palazzolo. “How patients' lack of knowledge aboutoral bisphosphonates can interfere with medical and dental care”. J Am Dent Assoc.141(5):562-6, 20105. [145] JS Bauer, N Beck, J Kiefer, P Stockmann, M Wichmann, S Eitner. “Awareness andeducation of patients receiving bisphosphonates”. J Craniomaxillofac Surg. , 2011(epub)6. [146] M Aapro, PA Abrahamsson, JJ Body, RE Coleman, R Colomer, L Costa, L Crinò,L Dirix, M Gnant, J Gralow, P Hadji, GN Hortobagyi, W Jonat, A Lipton, A Monnier,AH Paterson, R Rizzoli , F Saad, B Thürlimann. “Guidance on the use ofbisphosphonates in solid tumours: recommendations of an international expert panel”Ann Oncol. 19(3): pp 420-32, 20087. [147] RA Kyle, GC Yee, MR Somerfield, PJ Flynn, S Halabi, S Jagannath, RZ Orlowski,DG Roodman, P Twilde, K Anderson; American Society of Clinical Oncology.“American Society of Clinical Oncology 2007 clinical practice guideline update on therole of bisphosphonates in multiple myeloma”. J Clin Oncol. 25(17): pp2464-72, 200724
Azienda Ospedaliera Nazionale“SS. Antonio e Biagio e Cesare Arrigo”Working Paper of Public Healthnr. 12/2012FIGURES300000250000200000150000100000Zoledronic AcidPamidronateZoledronic Acid + Pamidronate5000002001 2002 2003 2004 2005 2006 2007 2008Figure 1: Number of prescribed units of pamidronate ( 1 unit = 90 mg) and zoledronic acid (1 unit = 4 mg)in Italy between 2001 and 2008 (elaboration from AIFA data, personal communication).Figure 2: Rate of prescribed units of zoledronic acid (1 unit = 4 mg) in Italy between 2001 and 2006, permillion of inhabitants, in several European countries (elaboration from AIFA data, personal communication).25
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