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Dicembre Vol.3 N° 3 - 2007 - Salute per tutti

Dicembre Vol.3 N° 3 - 2007 - Salute per tutti

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M. Cavallini, M. Papagnitaining long chain polynucleotides gel. The productmust be injected into the su<strong>per</strong>ficial dermaand the integration between the gel and thematrix of the dermis optimize the biore v a l i z a t i o naction of the skin.The purpose of this study is to describe the clinicalex<strong>per</strong>ience on skin biorevitalization withlong chain polynucleotides gel, focusing ons a f e t y, tolerability, techniques and clinical eff e c t s .atients and methodsPThe productP l i n e s t ® is a gel, consisting of highlypurified - natural origin long chain polynucleotides(20 mg/ml concentration) (4). It is markedin pre-filled glass syringe with 1.3 ml of highmolecular weight sterile and apirogenic polynucleotides.It is a class III medical device, biocompatible,of natural origin and allergy testingis not necessary. The product underwent manyin vitro and in vivo tests, showing the absence oflocal and systemic toxicity respecting the UNIrules of medical devices (cytotoxicity for dire c tcontact, allergic sensitization, mutagenicity test-Ames test, intracutaneous re a c t i v i t y, Irritationtest). In the clinical use it is noted a high tolerabilityand total absence of important side eff e c t s .Infiltration techniquesP l i n e s t ® is a handy product that can beinjected into derma with very thin needles(30G), which greatly reduce any discomfort tothe patient. The implant techniques used were :the serial puncture injections (micro whealstechnique), the re t rograde linear injections andthe cross-link technique.the serial puncture technique or micro whealstechnique consists of serial intra dermal injectionsevery 0,5-1 cm of small quantity of thep roduct to cover all the area to treat. This t e c h-nique can be used to treat the skin in every partof the face and of the body.the linear technique consists in the filling ofsu<strong>per</strong>ficial and/or medium dermis, followingthe wrinkles or the Langer lines, or in larg ea reas as the cheek or in the nasolabial folds.the cross-link technique consists of a net oflinear intersecting infiltrations. It allows thep roduct to distribute over the whole area, andis mainly suggested for treating larger areas, forinstance the cheek re g i o n .P a t i e n t sF rom June 2005 to May <strong>2007</strong>, 148patients of both sexes (134 females and 14males), with ages ranging from 32 to 75 years,w e re treated with long chain polynucleotides forskin biore v i t a l i z a t i o n .Inclusion criteria included: healthy patients, agesranging from 18 to 75 years, written informedconsent, five or more years of school, phototypeI-IV and if female not in pregnancy or bre a s t - f e e-ding. Exclusion criteria included: severe concomitantdiseases, hy<strong>per</strong>sensitivity to the product ins t u d y, abuse of alcohol or other drugs andsmoking (>20 cigarettes a day). Clinical evaluationswere carried out before treatment (T0) and30 days after the end of the initial treatment phase(follow up visit). The treatment efficacy was evaluatedby patient and physician assessment andby the analysis of digital pictures. The objectiveand subjective tolerability of the product usedwas evaluated during each intradermal infiltration.The physician assessment was evaluatedwith a quartiles scale (worsened, unchanged,i m p roved, highly improved) (5). The patientssatisfaction rate was evaluated during the followupvisit and has been re c o rded with a 0-10 visualanalogue scale (VAS) with 0 designated as theabsence of improvement and 10 the best improvementwith the best satisfaction of the patient.The VAS was chosen because it is easily administ e red and is well accepted by patients (6).Treated areasFace 132Neck 55Décolleté 14Back of the hands 9Total 210Table 1. Treated areas.Figure 1. Physician global assessment.28Journal of Plastic Dermatology <strong>2007</strong>; 3, 3

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