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Lali Akhaladze,Doctor of Biology, PhysiologistMikheil KhananashviliDoctor of Medical Sciences, ProfessorThe experimental model of psychogenic stressand self-regulatory behaviorFor modeling of the psychogenic stress we used the modified model of activeavoiding reaction. On different steps of the stress development, in testing differentcomplexity defense reaction development, reactions of fear and anxiety prevail in animals.Manifested by rats behavior provides the body adaptation, brain self-regulatory actionmanifestation in stressing situation, which is reflected as a certain ratio between thebehavior actions. The described action is explained as biologically positive stressmanifestation, which plays adapting role, increases, strengthens stability to stressingirritator and provides the homeostasis of mentality.220