aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
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o simptomebi mravalferovania.<br />
o SeSupebuli limfuri kvanZebi SesaZlebelia palpirdebodes<br />
sxva<strong>da</strong>sxva adgilze.<br />
o cxeleba, wonaSi kleba <strong>da</strong> sisuste xSiria, Tumca ara aucilebeli.<br />
o <strong>da</strong>avadebis stadiis gansazRvrisTvis (I-IV) aucilebelia Semdegi<br />
gamokvlevebi – cerebruli, cervikaluri, Torakaluri <strong>da</strong><br />
abdominaluri kompiuteruli aqsialuri tomografia (CAT)<br />
skanireba, Zvlis tvinis <strong>da</strong> Tav-zurg-tvinis siTxis biofsia <strong>da</strong><br />
gastrodkopia. diagnozi <strong>da</strong>sturdeba hiperplazirebuli limfuri<br />
kvanZis bifsiiT, histologiuri gamokvleviT.<br />
3.1.11.2. berkitis-tipis limfoma <strong>aiv</strong> inficirebulebSi<br />
berkitis limfoma ara hojkinis limfomis erT-erTi subtipia. berkitis<br />
limfoma asocirebulia <strong>aiv</strong> infeqciiasTan <strong>da</strong> SeiZleba ganviTardes<br />
gamoxatuli imunodeficitis ganviTarebamde. <strong>da</strong>dgenilia kavSiri am<br />
<strong>da</strong>avadebasa <strong>da</strong> epStein-baris viruss Soris.<br />
diagnostika<br />
berkitis –tipis limfomis diagnozi ismeba limfuri kvanZis <strong>da</strong> simsivnis<br />
bioptatebis histologiuri gamokvleviT.<br />
ara hojkinis, berkitis-tipis <strong>da</strong> cns-is lomfomebis <strong>mkurnaloba</strong><br />
o ara-hojkinis limfomebis samkurnalod efeqturia CHOP reJimi, un<strong>da</strong><br />
Catardes 6 kursi (ganmeorebebi aucilebelia sruli remisiis<br />
misaRebad)<br />
o prednizoloni 100 mg/dReSi erTxel 5 dRe<br />
o vinkristini (onkovini) 1,4 mg/m2 (maqsimum 2 mg/dReSi) erTi doza<br />
mkurnalobis pirvel dRes<br />
o ciklofosfamidi 750 mg/m2/dReSi erTi doza mkurnalobis pirvel<br />
dRes<br />
o doqsorubicini (hidroqsi<strong>da</strong>unomicini) 50 mg/m2/dReSi erTi doza<br />
mkurnalobis pirvel dRes.<br />
meore cikli iwyeba yovel 21-e dRes (dRe 22-e mohyveba I dRes)<br />
o EPOCH reJimi, romelic moicavs etopozids, prednozolons,<br />
vinkristins, ciklofisfamids <strong>da</strong> <strong>da</strong>unorubicins an diqsirubicins<br />
efeqturia arT-sTan kombinaciaSi. igi efuZneba gagrZelebiT<br />
infuzias 96 saaTis ganmavlobaSi, romelc Semdegia:<br />
o etopozidi 50 mg/m2 dReSi (centraluri venuri xaziT)<br />
o doqsorubucuni 10 mg/m2/dReSi (centraluri venuri xaziT)<br />
o vinkristini 0,4 mg/m2/dReSi (maqs 2 mg/kviraSi) (centraluri venuri<br />
xaziT)<br />
o ciklofosfamidi 375 mg/m2 me-5 dRes mxolod, bolusiT<br />
(centraluri venuri xaziT)<br />
o prednizoloni 100 mg/dReSi pirveli 5 dRe erTxel dReSi.<br />
reJimi un<strong>da</strong> ganmeordes yovel 21 dReSi sanam ar Catardeba 6 cikli.<br />
o berkitis–tipis limfomis menejmenti ar gansxvavdeba sxva<br />
limfomebis mkurnalobisgan <strong>da</strong> poasuxobs CHOP <strong>da</strong> EPOCH reJimebs<br />
(BII). swrafad mzardi limfomis <strong>mkurnaloba</strong> ufro agresiuli<br />
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