aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ... aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
ARV toqsiuroba menejmenti nefrotoqsiuroba tenofoviri TDF o Tirkmlis ukmarisoba da o kreatininis monitoringi, istoria Tirkmlis o fankonis sindromi ufro xSirad pacientebSi Tirkmlis disfunqciiT anemia zidovudini ZDV o anemia da neitropenia (sustad Semcireba iTvleba normad zidovudinTan) o 1-4%, dozaze damokidebulebiT periferiuli neiropaTia didanozini, stavudini, zalcitabini cximovani atrofia stavudini, da sxva nrti o o o o kidurebis tkivili, paresTezia 10-30% wlebis Semdeg loyisa da kidurebis cximis ganleva xangrZlivad gamoyenebis SemTxvevaSi xSiria (mitoqondriuli toqsiuroba) cximovani akumulacia PI o matulobs mucelze gacximovneba, mkerdis zoma, o 20-80% o o o o o o o o o o o daavadebis Sesaxeb mkurnaloba simtomuria tenofoviris dozis koreqcia (saWiroa kreatininis klirensi: yovel meore dRes Seicvalos tenofoviri zidovudiniT, abakaviriT an stavudiniT sisxlis saerTo analizis monitoringi 2, 4, 8, 12 kviraze. makrocitozi msubuqi anemiiT (hemoglobini 100 gr/l) xSiria mkurnaloba aris eriTropoetinis transfuzia (Zalze Zviria) an Seicvalos zidovudini sxva nrti (tenofoviri, abakaviri an stavudini) periferiuli nervuli sistemis kontroli mkurnaloba tkivilis kupireba, Seicvalos arT. Sewydes wamlebi an Seicvalos nrti (zidovudini, tenofoviri, abakaviri) monitoringi da sawyis mdgom. Sedareba Seicvalos stavudini tenofoviriT an abakaviriT. Tu atrofia Seuqcevadia plastikuri qirurgia naCvenebia Sefaseba da sawyis mdgom. Sedareba Seicvalos NNRTI-iT, Tu lipodistrofia/lipoatr ofia ar aris tolerantuli, naCvenebia plastikuri qirurgia nnrti>APV/fozamprenaviri FPV>abakaviriABC o makulur-papuluri gamonayari o 15% nnrti, APV 20%, abakaviri 5% o o cxelebis, RviZlis funqciuri sinjebis da kreatinkinazas monitoringi sxva alergenebis gamoricxva (sulfametoqsazol/trime toprimi da sxva antibi.). gamonayari SeiZleba spontanurad gaqres arT-s 48
transaminazebis elevacia anrti (all) da PIs (all) o auxsneli RviZlis funqciebis momateba o o 8-15% PI da nnrti ufro xSirad pacientebSi qronikuli HBV da HCV infeqciiT o o o o Semdeg Seicvalos nevirapini efavirenziT an piriqiT. Tu ar aris gaumjobeseba scadeT sxva reJimi ALT monitoringi yovel eqvs TveSi, gaTvaliswinebuli iqnas sxva faqtorebi (mag. wamlismieri hepatiti. momateba xSirad Tan axlavs nnrti da pi ganuwyvetel miRebas Sewydes nnrti da pi miReba ARV toqsiuroba menejmenti PIs (all),zidovudini ZDV,didanizini ddI o o gulisreva da Rebineba, diarea xSiria centraluri nervuli sistemis (cns) toqsiuroba efavirenzi EFV o Ramis SfoTva, koncentraciis darRveva, depresia (suicidisken midrekileba) o 50% insulin rezistentoba PIs (yvela magram ATV) o glukozis tolerantoba matulobs, glukoza matulobs uzmoze o 5% hiperlipidemia stavudini (d4T)>PIs (all but ATV) o lipidebis, qolesterolis, trigliceridebis momateba( am ukanasknelisTvis stavudini SeiZleba iyos wamyvani) o 0% 49 o o o o o o o o o o gamoiricxos sxva mizezi (imunuri rekonstituciis anTebiTi sindromi CMV kolitiT, kriptosporidiozi, mikrosporidiozi, arT-s dawyebidan kvireebis Semdeg mkurnaloba aris loperamidiT Tu diareis sxva mizezi ar aris: metoklopramidi, zofrane gulisrevis da Rebinebis dros pacientebis gafrTxileba, fsiqiatris konsultacia mkurnaloba Cveulebriv saWiro ar aris. aRniSnuli movlenebi gaivlis 5-21 dReSi uzmoze glukozis monitoringi mkurnaloba dietiT da metforminis an glitazonis miReba Seicvalos pi nnrti-iT lipidebis donis monitoringi arT-s dawyebidan da Semdeg yovel eqvs TveSi mkurnaloba lipidebis, qolesterolis da trigliceridis gaidlainebiT sifrTxilea saWiro urTierTzemoqmedebisas (ar SeiZleba simvastatini da
- Page 1 and 2: aiv infeqcia/SidsiT avadmyofTa mkur
- Page 3 and 4: sarCevi klinikuri saxelmZRvanelo-re
- Page 5 and 6: 3.2.2.cxeleba aiv inficirebulebSi 3
- Page 7 and 8: aiv infeqcia/Sidsis fonze ganviTare
- Page 9 and 10: done mtkicebulebis siZlieris done (
- Page 11 and 12: 1.daavadebis definicia Sidsi abrevi
- Page 13 and 14: Sidsi registrirebulia msoflios 216
- Page 15 and 16: egistrirebul SemTxveevaTa 79% saqar
- Page 17 and 18: adamianis imunodeficitis virusis sa
- Page 19 and 20: aiv rnm-is koncentracia plazmaSi mk
- Page 21 and 22: SeuZlebelia da gadamwyveti misi dia
- Page 23 and 24: persistuli generalizebuli limfadeno
- Page 25 and 26: signalis amplifikacia komplementuri
- Page 27 and 28: • vizitamde rezistentobis testis
- Page 29 and 30: • adamianis papilomavirusi (maxvi
- Page 31 and 32: etinitis identifikaciisTvis, rodesa
- Page 33 and 34: cxrili 8 rekomendaciebi arT dawyebi
- Page 35 and 36: arv medikamentebi arseboben Semdegi
- Page 37 and 38: aCveneben, rom pirveladi rezistento
- Page 39 and 40: - tabletebis Cveneba pacientisTvis
- Page 41 and 42: - aqedan gamomdinare, nrti+anrti re
- Page 43 and 44: igulisxmeba im medikamentebis kombi
- Page 45 and 46: X (arv): testebi, romlebic unda Cat
- Page 47: maRali mgrZnobeloba abakaviri (ABC
- Page 51 and 52: ARV toqsiuroba menejmenti nefrotoqs
- Page 53 and 54: xSiri oportonistuli infeqciebia, ma
- Page 55 and 56: cxrilebis wakiTxvis magaliTi 1. cxr
- Page 57 and 58: damateba2. jandacvis msoflio organi
- Page 59 and 60: damateba 4. ZiriTadi informacia ant
- Page 62 and 63: damateba 5. mkurnalobis reJimis dac
- Page 64 and 65: saerTaSoriso saxeli stavudini (d4T)
- Page 66 and 67: mcire mutacia muSaobs kombinaciaSi.
- Page 68 and 69: 25. Phillips AN et al. Viral load o
- Page 70 and 71: Suppl 2:S171-176. 73. Altice FL, Mo
- Page 72 and 73: 122. Koval CE et al. Immune reconst
- Page 74 and 75: kandidozi dRe yovel dRe - ko-trimoq
- Page 76 and 77: karcinoma (ara SidsTan perikardiuli
- Page 78 and 79: o cxeleba o wonaSi kleba o Ramis of
- Page 80 and 81: indikatorebi filtvis darRveuli funq
- Page 82 and 83: o yvelaze xSirad viTardeba diarea,
- Page 84 and 85: o glukokortikoidebis sistematiuri m
- Page 86 and 87: 100 mg/dReSi meore rigis sqemebi am
- Page 88 and 89: o eqspoziciis Sedegad daavadebis ga
- Page 90 and 91: o remisiis miRweva Zalian Znelia da
- Page 92 and 93: qimioTerapiiT (mag : B-ALL reJimi)
- Page 94 and 95: • imunodeficitis mqone pacientebS
- Page 96 and 97: an famcikloviri 500 mg 3-jer dReSi
ARV toqsiuroba menejmenti<br />
nefrotoqsiuroba<br />
tenofoviri TDF o Tirkmlis<br />
ukmarisoba <strong>da</strong><br />
o kreatininis monitoringi,<br />
istoria Tirkmlis<br />
o<br />
fankonis sindromi<br />
ufro xSirad<br />
pacientebSi<br />
Tirkmlis<br />
disfunqciiT<br />
anemia<br />
zidovudini ZDV o anemia <strong>da</strong><br />
neitropenia (sustad<br />
Semcireba iTvleba<br />
normad<br />
zidovudinTan)<br />
o 1-4%, dozaze<br />
<strong>da</strong>mokidebulebiT<br />
periferiuli neiropaTia<br />
di<strong>da</strong>nozini, stavudini,<br />
zalcitabini<br />
cximovani atrofia<br />
stavudini, <strong>da</strong> sxva nrti<br />
o<br />
o<br />
o<br />
o<br />
kidurebis tkivili,<br />
paresTezia<br />
10-30% wlebis<br />
Semdeg<br />
loyisa <strong>da</strong><br />
kidurebis cximis<br />
ganleva<br />
xangrZlivad<br />
gamoyenebis<br />
SemTxvevaSi xSiria<br />
(mitoqondriuli<br />
toqsiuroba)<br />
cximovani akumulacia<br />
PI o matulobs mucelze<br />
gacximovneba,<br />
mkerdis zoma,<br />
o 20-80%<br />
o<br />
o<br />
o<br />
o<br />
o<br />
o<br />
o<br />
o<br />
o<br />
o<br />
o<br />
<strong>da</strong>avadebis Sesaxeb<br />
<strong>mkurnaloba</strong> simtomuria<br />
tenofoviris dozis<br />
koreqcia (saWiroa<br />
kreatininis klirensi:<br />
yovel meore dRes<br />
Seicvalos tenofoviri<br />
zidovudiniT, abakaviriT<br />
an stavudiniT<br />
sisxlis saerTo analizis<br />
monitoringi 2, 4, 8, 12<br />
kviraze. makrocitozi<br />
msubuqi anemiiT<br />
(hemoglobini 100 gr/l)<br />
xSiria<br />
<strong>mkurnaloba</strong> aris<br />
eriTropoetinis<br />
transfuzia (Zalze<br />
Zviria) an Seicvalos<br />
zidovudini sxva nrti<br />
(tenofoviri, abakaviri an<br />
stavudini)<br />
periferiuli nervuli<br />
sistemis kontroli<br />
<strong>mkurnaloba</strong> tkivilis<br />
kupireba, Seicvalos arT.<br />
Sewydes wamlebi an<br />
Seicvalos nrti<br />
(zidovudini, tenofoviri,<br />
abakaviri)<br />
monitoringi <strong>da</strong> sawyis<br />
mdgom. Se<strong>da</strong>reba<br />
Seicvalos stavudini<br />
tenofoviriT an<br />
abakaviriT. Tu atrofia<br />
Seuqcevadia plastikuri<br />
qirurgia naCvenebia<br />
Sefaseba <strong>da</strong> sawyis mdgom.<br />
Se<strong>da</strong>reba<br />
Seicvalos NNRTI-iT, Tu<br />
lipodistrofia/lipoatr<br />
ofia ar aris<br />
tolerantuli, naCvenebia<br />
plastikuri qirurgia<br />
nnrti>APV/fozamprenaviri<br />
FPV>abakaviriABC<br />
o makulur-papuluri<br />
gamonayari<br />
o 15% nnrti, APV 20%,<br />
abakaviri 5%<br />
o<br />
o<br />
cxelebis, RviZlis<br />
funqciuri sinjebis <strong>da</strong><br />
kreatinkinazas<br />
monitoringi<br />
sxva alergenebis<br />
gamoricxva<br />
(sulfametoqsazol/trime<br />
toprimi <strong>da</strong> sxva antibi.).<br />
gamonayari SeiZleba<br />
spontanurad gaqres arT-s<br />
48
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