aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
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4. <strong>mkurnaloba</strong>ze uSualo ze<strong>da</strong>mxedveloba, gansakuTrebiT<br />
hospitalSi<br />
o fsiqosocialuri <strong>da</strong>xmareba<br />
o pacients miewodos saxelmZRvanelo <strong>da</strong> broSurebi<br />
o pacientebis monawileoba <strong>da</strong>xmarebis jgufebSi<br />
5. 4. arv toqsiuroba <strong>da</strong> gverdiTi efeqtebis menejmenti<br />
gverdiTi efeqtebi xSiria arv Terapiis dros, gansakuTrebiT proteazas<br />
inhibitorebis miRebis dros (ix. cxrili 13).<br />
o lopinavir/ritonavirs <strong>da</strong> nelfinavirs SeuZliaT gamoiwvion diarea<br />
o lopinaviri/ritonaviris miReba asocirebulia hiperlipidemiasTan<br />
(gansakuTrebiT trigliceridebis momatebasTan)<br />
o cximebis metabolizmis <strong>da</strong>rRvevebi SeiZleba gamoiwvios TiTqmis<br />
yvela proteazas inhibitorebma<br />
o erTaderTi proteazas inhibitori, romelic gavlenas ar axdens<br />
lipidur cvlaze aris atazanaviri <strong>da</strong> atazanavir/ritonaviri.<br />
zogierT qveyanaSi atazanaviri mowodebulia mkurnalobis meore<br />
rigis sqemaSi<br />
o kardiovaskularuli garTulebebis riskis momateba saWiroebs<br />
Semdgom Seswavlas<br />
cxrili 13<br />
arv-s toqsiurobis <strong>da</strong><strong>da</strong>stureba <strong>da</strong> menejmenti<br />
ARV toqsiuroba menejmenti<br />
RviZlis nekrozi<br />
nevirapini (NVP) o cxeleba, gamonayari (50%),<br />
gulisreva, Rebineba,<br />
eozinofilia, alt, ast-s<br />
donis momateba<br />
o<br />
o Cveulebriv pirvel 6-18<br />
kviraSi, iSviaTad 48<br />
kviris Semdeg<br />
o<br />
o<br />
laqtat-acidozi<br />
maRli<strong>da</strong>n <strong>da</strong>bali<br />
riskisken:<br />
o stavudini<br />
di<strong>da</strong>nozinTan<br />
erTad<br />
o di<strong>da</strong>nozini<br />
o stavudini<br />
o zidovudini<br />
o<br />
o<br />
o<br />
nevirapinze myofi<br />
pacientebis 1-2%, qalebSi<br />
CD4 > 250 ; kacebSi CD4 ><br />
400-ze<br />
gulisreva, Rebineba,<br />
wonaSi <strong>da</strong>kleba, sisuste,<br />
pankreatiti,<br />
multiorganuli<br />
ukmarisoba,<br />
respiratoruli distres<br />
sindromi<br />
yoveli 1000 pacienti<strong>da</strong>n<br />
1-10 weliwadSi<br />
di<strong>da</strong>nozini <strong>da</strong> stavudini<br />
46<br />
o<br />
o<br />
o<br />
RviZlis funqciuri<br />
sinjebis monitoringi 2,<br />
4, 8, 16 kviraze <strong>da</strong><br />
Semdeg yovel 3 TveSi<br />
simptomuri <strong>mkurnaloba</strong><br />
RviZlis nekrozis<br />
<strong>mkurnaloba</strong>, calkeul<br />
klinikur SemTxvevebSi<br />
wamlebis Sewyveta<br />
laqtat-acidozis<br />
monitoringi Tu eWvia,<br />
inaxos adreuli<br />
indikatorebi<br />
(kreatinkinaza (CK)<br />
HCO3)<br />
acidozis samkurnalod<br />
mowodebulia<br />
bikarbonati<br />
abakaviriT,<br />
tenofoviriT,<br />
lamivudiniT,<br />
emtricitabiniT Secvla
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