aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
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imunokomproometirebulebSi kanisa <strong>da</strong> lorwovanis banaluri <strong>da</strong>avadebebi<br />
mimdinareobs rTulad, aqvs persistuli xasiaTi <strong>da</strong> rTulia samkurnalod.<br />
qvemoT, mokled aris <strong>da</strong>xasiTebuli kanisa <strong>da</strong> lorwovanis is <strong>da</strong>avadebebi,<br />
romlebic ufro xSirad viTardeba <strong>aiv</strong> <strong>infeqcia</strong>/Sidsis fonze.<br />
Sesabamisad, klinicistma qvemoT aRwerili kanis <strong>da</strong> lorwovanis<br />
romelime <strong>da</strong>avadebis identifikaciisas avadmyofi un<strong>da</strong> gamoikvlios <strong>aiv</strong><br />
antisxeulebze.<br />
5. <strong>da</strong>avadebis diagnozi<br />
laboratoriuli diagnostika<br />
vinai<strong>da</strong>n <strong>aiv</strong> <strong>infeqcia</strong>s paTognomuri <strong>klinikuri</strong> niSnebi ar gaaCnia,<br />
ga<strong>da</strong>mwyveti mis diagnostikaSi laboratoriuli gamokvlevaa.<br />
<strong>aiv</strong> infeqciis laboratoriuli diagnostika sxva<strong>da</strong>sxva meTodiT<br />
xorcieldeba, virusis kultivireba Semdgomi idenTifikaciiT, sisxlsa <strong>da</strong><br />
sxva biologiur siTxeebSi virusis antigenis <strong>da</strong> antisxeulebis<br />
gansazRvra, virusis genomis gamovlena <strong>da</strong> sxva.<br />
dReisaTvis <strong>aiv</strong> infeqciis laboratoriuli diagnostikis ZiriTadi<br />
saSualebebia sisxlSi <strong>aiv</strong> sawinaaRmdego antisxeulebis <strong>da</strong> virusis<br />
genetikuri masalis gansazRvra.<br />
<strong>aiv</strong> antisxeulebis gansazRvris meTodebi or jgufad iyofa – pirveladi<br />
anu skrininguli <strong>da</strong> <strong>da</strong>ma<strong>da</strong>sturebeli anu komfirmaciuli. skriningul<br />
meTodebs miekuTvneba: <strong>aiv</strong> antisxeulebis gamovlena imunofermentuli<br />
analizis (ifa), imunofluorescenciis, hemaglutinaciis,<br />
imunoqromatografiis, mikroprecipitaciis <strong>da</strong> sxva meTodebiT.<br />
gamokvlevis xangrZlivobis mixedviT es meTodebi iyofa Cveulebriv<br />
(xangrZlivoba 2-5 saaTi) <strong>da</strong> swraf/martiv (xangrZlivoba 5-30 wuTi)<br />
meTodebad. konfirmaciuli meTodebi<strong>da</strong>n ZiriTa<strong>da</strong>d gamoiyeneba<br />
imunoblotingi (Western blot).<br />
skriningul meTodebs Soris yvelaze farTod gamoiyeneba <strong>aiv</strong><br />
antisxeulebis gamovlena ifa <strong>da</strong> swrafi/martivi meTodebiT, romlebic<br />
maRali mgrZnobelobiTa <strong>da</strong> specifikurobiT xasiaTdeba <strong>da</strong> amasTan,<br />
advilad xelmisawvdomia. maTi saSualebiT <strong>aiv</strong> antisxeulebi sisxlSi<br />
vlindeba inficirebi<strong>da</strong>n 4-8 kviris Semdeg. <strong>da</strong>debiTi Sedegis SemTxvevaSi<br />
kvleva grZeldeba <strong>da</strong>ma<strong>da</strong>sturebeli anu, konfirmaciuli meTodiT –<br />
imunoblotingiT (Western blot). imunoblotingis meTodi saSualebas iZleva<br />
ganisazRvros specifikuri antigenebis, anu virusis calkeuli cilebis<br />
sawinaaRmdego antisxeulebi.<br />
sadReisod yvelaze zusti <strong>da</strong> maRalmgrZnobiare meTodia virusis genomis<br />
(rnm, dnm) gamovlena polimerizaciis jaWvuri reaqciis (PCR) meTodiT.<br />
arsebobs virusis genomis gamovlenis alternatiuli meTodebic – bDNA<br />
(branched chain DNA) <strong>da</strong> NASBA (Nucleic Acid Sequence-Based Amplification). Tumca<br />
Tavisi mgrZnobelobiTa <strong>da</strong> specifikurobiT sadReisod isini PCR meTods<br />
CamorCeba. bDNA meTodiT xdeba virusis rnm-is moniSnuli monakveTi<strong>da</strong>n<br />
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