aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ... aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
dinamikaSi dakvirveba CD4≥500/mm 3 CD420000IU/ml HBeAg(+) pozitiurisTvis, HBV DNA>2000IU/ml HBeAg(-) negatiurisTvis. ** Metavir _F2 HBV/HIV koinfeqciiT avadmyofebisTvis, romelTac ar esaWiroebaT arv mkurnaloba HBV infeqciis samkurnalod SerCevis preparati aris interferoni. mkurnalobis reJimebi aris Semdegi: 1. HBeAg (+) pozitiuri avadmyofebisTvis. standartuli INF 5-6 MU/dReSi an 10 MU 3-jer kviraSi 4-6 Tve. 2. HBeAg (-) negatiuri avadmyofebisTvis. standartuli INF 3-6 MU 3-jer kviraSi 12 Tve. an 3. PEG-INF 2a 180mkg 1- jer kviraSi 12 Tve. HBeAg/ anti-HBe statusisgan damoukideblad. 4. im SemTxvevaSi Tu interferoni ukunaCvenebia gamoyenebul unda iqnas adefoviri 10mg dReSi. 2. HBV mkurnalobis algoriTmi HIV koinfeqciiT avadmyofebisTvis, romelTac WirdebaT arv mkurnaloba. H HBV/HIV koinfeqciiT avadmyofebi romelTac WirdebaT HAART . maRali HBV DNA dabali HBV DNA avadmyofebi ciroziT lamivudin rezistentuli avadmyofebi HAART SerCevis reJimi 188 HAART romelSic Sedis tenofoviri + lamivudini an emtricitabini
avadmyofebi lamivudinis mimarT rezistentobis gareSi HAART romelSic Sedis tenofoviri + lamivudini an emtricitabini unda Canacvldes erTi NRTI tenofoviriT an daematos tenofoviri HBV/HIV koinfeqciiT avadmyofebisTvis, romelTac esaWiroebaT arv mkurnaloba da HBV mkurnaloba gaTvaliswinebul unda iqnas Semdegi: a) Tu HBV DNA aris maRali koncentraciiT, maSin HAART aucileblad unda Seicavdes or medikaments romelsac gaaCnia ormagi aqtivoba rogorc HBV aseve HIV mimarT. b) lamivudinis mimarT rezistentobis SemTxvevaSi, roca HIV infeqcia kontrolirebadia, erT-erTi NRTI unda Seicvalos tenofoviriT. g) lamivudinis mimarT rezistentobis SemTxvevaSi, roca HIV infeqcia kargad ar kontrolirdeba, pirvel rigSi yuradreba unda mieqces HHAART-s, romelic kargad gaakontrolebs aiv infeqcias da daematos tenofoviri. d) avadmyofebSi romelTac aqvT cirozi HBV mkurnalobis sakiTxi unda gadawydes HBV DNA-s dabali maCveneblis dros. (HBV DNA>200IU/ml). aseT avadmyofebSi interferoni ukunaCvenebia. D fulminanturi mwvave B hepatitis mkurnaloba HIV koinfeqciiT avadmyofebSi Cveulebriv mwvave B hepatiti SemTxvevaTa maRal procentSi mTavrdeba gamojanmrTelebiT da amitom mkurnalobas ar saWiroebs. fulminanturi mwvave B hepatitis SemTxvevaSi lamivudiniT mkurnaloba unda iqnas ganxiluli, miuxedavad aiv-is mimarT rezistentobis ganviTarebis riskisa. tenofoviris da adefoviris daniSvnisgan Tavi unda iqnas Sekavebuli am medikamentebis gamoxatuli nefrotoqsiurobis gamo. 6.reabilitacia da dakvirveba 189
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avadmyofebi<br />
lamivudinis mimarT<br />
rezistentobis<br />
gareSi<br />
HAART romelSic<br />
Sedis tenofoviri<br />
+ lamivudini an<br />
emtricitabini<br />
un<strong>da</strong> Canacvldes erTi<br />
NRTI tenofoviriT an<br />
<strong>da</strong>ematos tenofoviri<br />
HBV/HIV koinfeqciiT avadmyofebisTvis, romelTac esaWiroebaT arv<br />
<strong>mkurnaloba</strong> <strong>da</strong> HBV <strong>mkurnaloba</strong> gaTvaliswinebul un<strong>da</strong> iqnas Semdegi:<br />
a) Tu HBV DNA aris maRali koncentraciiT, maSin HAART aucileblad<br />
un<strong>da</strong> Seicavdes or medikaments romelsac gaaCnia ormagi aqtivoba<br />
rogorc HBV aseve HIV mimarT.<br />
b) lamivudinis mimarT rezistentobis SemTxvevaSi, roca HIV <strong>infeqcia</strong><br />
kontrolirebadia, erT-erTi NRTI un<strong>da</strong> Seicvalos tenofoviriT.<br />
g) lamivudinis mimarT rezistentobis SemTxvevaSi, roca HIV <strong>infeqcia</strong><br />
kargad ar kontrolirdeba, pirvel rigSi yuradreba un<strong>da</strong> mieqces<br />
HHAART-s, romelic kargad gaakontrolebs <strong>aiv</strong> <strong>infeqcia</strong>s <strong>da</strong> <strong>da</strong>ematos<br />
tenofoviri.<br />
d) avadmyofebSi romelTac aqvT cirozi HBV mkurnalobis sakiTxi un<strong>da</strong><br />
ga<strong>da</strong>wydes HBV DNA-s <strong>da</strong>bali maCveneblis dros. (HBV DNA>200IU/ml). aseT<br />
avadmyofebSi interferoni ukunaCvenebia.<br />
D<br />
fulminanturi mwvave B hepatitis <strong>mkurnaloba</strong> HIV koinfeqciiT<br />
avadmyofebSi<br />
Cveulebriv mwvave B hepatiti SemTxvevaTa maRal procentSi mTavrdeba<br />
gamojanmrTelebiT <strong>da</strong> amitom <strong>mkurnaloba</strong>s ar saWiroebs.<br />
fulminanturi mwvave B hepatitis SemTxvevaSi lamivudiniT <strong>mkurnaloba</strong><br />
un<strong>da</strong> iqnas ganxiluli, miuxe<strong>da</strong>vad <strong>aiv</strong>-is mimarT rezistentobis<br />
ganviTarebis riskisa.<br />
tenofoviris <strong>da</strong> adefoviris <strong>da</strong>niSvnisgan Tavi un<strong>da</strong> iqnas Sekavebuli am<br />
medikamentebis gamoxatuli nefrotoqsiurobis gamo.<br />
6.reabilitacia <strong>da</strong> <strong>da</strong>kvirveba<br />
189
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