aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ... aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
imunokompetenturi ujredebis, upiratesad, CD4+ limfocitebis destruqcia, imunuri sistemis funqciis moSlas da Rrma imunodeficitis ganviTarebas iwvevs. 4. klinikuri simptomatika aiv infeqciis klinikuri speqtri aiv infeqciis bunebriv mimdinareobaSi (mkurnalobis gareSe) gamoyofen Semdeg stadiebs: virusis organizmSi SeWridan – 2-3 kviraSi viTardeba e.w. mwvave retrovirusuli sindromi – 2-3 kvira; klinikuri gaumjobeseba da serokonversia – 2-4 kvira; asimptomuri qronikuli aiv infeqcia – saSualod 8 weli; simptomuri aiv infeqcia/Sidsi – saSualod 1,3 weli; sikvdili. aiv infeqciis pirveladi gamovlinebaa mwvave retrovirusuli sindromi, romelsac Tan axlavs CD4+ limfocitebis ricxvis mkveTri daqveiTeba, plazmaSi maRali viremia. cxrili #1 pirveladi aiv infeqcia: Civilebi da simptomebi (2002; US DHHS) cxeleba – 96% mialgia – 54% hepatosplenomegalia – 14% adenopaTia - 74% diarea – 32% wonaSi kleba – 13% faringiti – 70% Tavis tkivili – 43% rZiana –12% gamonayari – 70% (eriTematozuli makulopapuluri gamonayari saxesa da tanze, iSviaTad – xelisa da fexis gulebze, zogi aRniSnavs wylulovan gamonayars piris RruSi, saylapavisa da genitaluri organoebis lorwovanze) sisuste da moTenTiloba – 27% nevrologiuri gamovlinebebi – 12% (aseptiuri meningiti, meningoencefaliti, periferiuli neiropaTia, giien-bares sindromi, nevriti, darRvevebi fsiqozuri mdgomareoba) mxris kognitiuri an klinikuri gaumjobesebis fazaSi aRiniSneba plazmaSi viremiis Semcireba, citotoqsiuri T limfocitebiT ganpirobebuli imunuri pasuxi. CD4+ limfocitebis ricxvis daqveiTeba kavSirSia virusuli datvirTvis matebasTan, rac Sidsis ganviTarebisa da avadmyofis sikvdilis mizezia. 2002 wels Catarebuli erT-erTi gamokvlevis SedegebiT CD4+ limfocitebis ricxvi aiv rnm-is koncentraciis yoveli log10-iT matebisas 1 ml-Si saSualod 4%-iT iklebs weliwadSi. 18
aiv rnm-is koncentracia plazmaSi mkveTrad imatebs mwvave infeqciis periodSi da Semdeg iklebs, rac serokonversiisa da imunuri pasuxis Sedegia. daavadebis gviani stadia xasiaTdeba CD4+ limfocitebis ricxvis daqveiTebiT
- Page 1 and 2: aiv infeqcia/SidsiT avadmyofTa mkur
- Page 3 and 4: sarCevi klinikuri saxelmZRvanelo-re
- Page 5 and 6: 3.2.2.cxeleba aiv inficirebulebSi 3
- Page 7 and 8: aiv infeqcia/Sidsis fonze ganviTare
- Page 9 and 10: done mtkicebulebis siZlieris done (
- Page 11 and 12: 1.daavadebis definicia Sidsi abrevi
- Page 13 and 14: Sidsi registrirebulia msoflios 216
- Page 15 and 16: egistrirebul SemTxveevaTa 79% saqar
- Page 17: adamianis imunodeficitis virusis sa
- Page 21 and 22: SeuZlebelia da gadamwyveti misi dia
- Page 23 and 24: persistuli generalizebuli limfadeno
- Page 25 and 26: signalis amplifikacia komplementuri
- Page 27 and 28: • vizitamde rezistentobis testis
- Page 29 and 30: • adamianis papilomavirusi (maxvi
- Page 31 and 32: etinitis identifikaciisTvis, rodesa
- Page 33 and 34: cxrili 8 rekomendaciebi arT dawyebi
- Page 35 and 36: arv medikamentebi arseboben Semdegi
- Page 37 and 38: aCveneben, rom pirveladi rezistento
- Page 39 and 40: - tabletebis Cveneba pacientisTvis
- Page 41 and 42: - aqedan gamomdinare, nrti+anrti re
- Page 43 and 44: igulisxmeba im medikamentebis kombi
- Page 45 and 46: X (arv): testebi, romlebic unda Cat
- Page 47 and 48: maRali mgrZnobeloba abakaviri (ABC
- Page 49 and 50: transaminazebis elevacia anrti (all
- Page 51 and 52: ARV toqsiuroba menejmenti nefrotoqs
- Page 53 and 54: xSiri oportonistuli infeqciebia, ma
- Page 55 and 56: cxrilebis wakiTxvis magaliTi 1. cxr
- Page 57 and 58: damateba2. jandacvis msoflio organi
- Page 59 and 60: damateba 4. ZiriTadi informacia ant
- Page 62 and 63: damateba 5. mkurnalobis reJimis dac
- Page 64 and 65: saerTaSoriso saxeli stavudini (d4T)
- Page 66 and 67: mcire mutacia muSaobs kombinaciaSi.
imunokompetenturi ujredebis, upiratesad, CD4+ limfocitebis<br />
destruqcia, imunuri sistemis funqciis moSlas <strong>da</strong> Rrma imunodeficitis<br />
ganviTarebas iwvevs.<br />
4. <strong>klinikuri</strong> simptomatika<br />
<strong>aiv</strong> infeqciis <strong>klinikuri</strong> speqtri<br />
<strong>aiv</strong> infeqciis bunebriv mimdinareobaSi (mkurnalobis gareSe) gamoyofen<br />
Semdeg stadiebs:<br />
virusis organizmSi SeWri<strong>da</strong>n – 2-3 kviraSi viTardeba e.w.<br />
mwvave retrovirusuli sindromi – 2-3 kvira;<br />
<strong>klinikuri</strong> gaumjobeseba <strong>da</strong> serokonversia – 2-4 kvira;<br />
asimptomuri qronikuli <strong>aiv</strong> <strong>infeqcia</strong> – saSualod 8 weli;<br />
simptomuri <strong>aiv</strong> <strong>infeqcia</strong>/Sidsi – saSualod 1,3 weli;<br />
sikvdili.<br />
<strong>aiv</strong> infeqciis pirveladi gamovlinebaa mwvave retrovirusuli sindromi,<br />
romelsac Tan axlavs CD4+ limfocitebis ricxvis mkveTri <strong>da</strong>qveiTeba,<br />
plazmaSi maRali viremia.<br />
cxrili #1<br />
pirveladi <strong>aiv</strong> <strong>infeqcia</strong>: Civilebi <strong>da</strong> simptomebi (2002; US DHHS)<br />
cxeleba – 96% mialgia – 54% hepatosplenomegalia –<br />
14%<br />
adenopaTia - 74% diarea – 32% wonaSi kleba – 13%<br />
faringiti – 70% Tavis tkivili – 43% rZiana –12%<br />
gamonayari – 70%<br />
(eriTematozuli makulopapuluri<br />
gamonayari<br />
saxesa <strong>da</strong> tanze,<br />
iSviaTad – xelisa <strong>da</strong><br />
fexis gulebze, zogi<br />
aRniSnavs wylulovan<br />
gamonayars piris RruSi,<br />
saylapavisa <strong>da</strong><br />
genitaluri organoebis<br />
lorwovanze)<br />
sisuste<br />
<strong>da</strong><br />
moTenTiloba – 27%<br />
nevrologiuri<br />
gamovlinebebi – 12%<br />
(aseptiuri meningiti,<br />
meningoencefaliti,<br />
periferiuli<br />
neiropaTia, giien-bares<br />
sindromi,<br />
nevriti,<br />
<strong>da</strong>rRvevebi<br />
fsiqozuri<br />
mdgomareoba)<br />
mxris<br />
kognitiuri<br />
an<br />
<strong>klinikuri</strong> gaumjobesebis fazaSi aRiniSneba plazmaSi viremiis Semcireba,<br />
citotoqsiuri T limfocitebiT ganpirobebuli imunuri pasuxi.<br />
CD4+ limfocitebis ricxvis <strong>da</strong>qveiTeba kavSirSia virusuli <strong>da</strong>tvirTvis<br />
matebasTan, rac Sidsis ganviTarebisa <strong>da</strong> avadmyofis sikvdilis mizezia.<br />
2002 wels Catarebuli erT-erTi gamokvlevis SedegebiT CD4+<br />
limfocitebis ricxvi <strong>aiv</strong> rnm-is koncentraciis yoveli log10-iT<br />
matebisas 1 ml-Si saSualod 4%-iT iklebs weliwadSi.<br />
18
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