aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
aiv infeqcia/SidsiT avadmyofTa mkurnaloba da movla (klinikuri ...
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<strong>aiv</strong> <strong>infeqcia</strong>/Sidsis fonze ganviTarebuli kriptokokuli meningitis<br />
marTvis saxelmwifo stan<strong>da</strong>rti (protokoli)<br />
1.<strong>da</strong>avadebis /nozologiis / sindromis mokle ganmarteba _ <strong>aiv</strong><br />
<strong>infeqcia</strong>/Sidsi ewodeba a<strong>da</strong>mianis imunodeficitis virusiT gamowveul<br />
infeqciur <strong>da</strong>avadebas. kriptokokuli meningitis gamomwvevia soko<br />
Criptococcus neoformans.<br />
2.kriteriumebi _<br />
a)<strong>da</strong>ma<strong>da</strong>sturebeli _ <strong>aiv</strong> <strong>infeqcia</strong>/Sidsis <strong>da</strong>ma<strong>da</strong>sturebeli kriteriumebia:<br />
<strong>aiv</strong> antisxeulebis arseboba sisxlis SratSi imunoblotingis meTodiT,<br />
<strong>aiv</strong> rnm-is raodenobrivad <strong>da</strong>/an <strong>aiv</strong> provirus dnm-is Tvisobrivad aRmoCena<br />
sisxlSi polimerizaciis jaWvuri reaqciis meTodiT. kriptokokozis<br />
diagnozis <strong>da</strong><strong>da</strong>sturebisTvis liqvors acentrifugireben, miRebul naleqs<br />
ikvleven mikroskopis qveS tuSis wveTis India ink <strong>da</strong>matebis Semdeg.<br />
preparatSi naxuloben sqeli kafsuliT <strong>da</strong>farul safuaris ujredebs.<br />
SesaZlebelia kriptokokis kulturis gamoyofa Tavzurgtvinis<br />
siTxi<strong>da</strong>n.gamoiyeneba Sratis <strong>da</strong> Tavzurgtvinis siTxis gamokvleva<br />
kriptokokul antigenze.<br />
b)gamomricxavi _ <strong>aiv</strong> <strong>infeqcia</strong>/Sidsis gamomricxavi kriteriumebia: <strong>aiv</strong><br />
antisxeulebis ar arseboba sisxlis SratSi imunofermentuli meTodiT,<br />
raodenobrivad <strong>aiv</strong> rnm-is <strong>da</strong>/an Tvisobrivad <strong>aiv</strong> provirus dnm-is ar<br />
arseboba sisxlSi polimerizaciis jaWvuri reaqciis meTodiT.<br />
kriptokokozis gamomricxavi kriteriumebia liqvorSi sqeli kafsuliT<br />
<strong>da</strong>faruli safuaris ujredebis ar arseboba.<br />
3.simptomebi <strong>da</strong> niSnebi<br />
a)<strong>da</strong>ma<strong>da</strong>sturebeli _ <strong>aiv</strong> <strong>infeqcia</strong>/Sidss paTognomuri <strong>klinikuri</strong> niSnebi<br />
ar gaaCnia. igi miekuTvneba laboratoriulad sadiagnozo <strong>da</strong>avadebebs.<br />
simptomebi<strong>da</strong>n SeiZleba gamovyoT: gaxangrZlivebuli cxeleba,<br />
gaxangrZlivebuli faRaraTi, limfadenopaTia, aramotivirebuli<br />
profuzuli oflianoba, Zlieri saerTo sisuste, aramotivirebuli wonaSi<br />
kleba (erTi Tvis ganmavlobaSi sxeulis wonis 10% <strong>da</strong> meti), sxva<strong>da</strong>sxva<br />
gamonayari kansa <strong>da</strong> lorwovanze, kandidozuri ezofagiti, cns-is<br />
atipiuri <strong>da</strong>zianebebi <strong>da</strong> sxva. kriptokokuli meningitis dros pacienti<br />
uCivisL Tavis tkivils, cxelebas, saxezea kefis kunTebis regidoba, Tavis<br />
qalis nervebis <strong>da</strong>zianeba, cnobierebis <strong>da</strong>rRveva, komatozuri<br />
mdgomareoba. xSirad SesaZlebelia ar aRiniSnos meningitis niSnebi, maT<br />
Soris, cxeleba <strong>da</strong> kefis kunTebis rigidoba.<br />
b)gamomricxavi _ <strong>aiv</strong> <strong>infeqcia</strong>/Sidsis gamomricxavi simptomebi ar<br />
arsebobs, <strong>aiv</strong> inficirebuli wlebis ganmavlobaSi SeiZleba Civilebs ar<br />
warmoadgendes. kriptokokuli meningitis gamomricxavi faqtoria<br />
Sesabamisi Civilebisa <strong>da</strong> simptomebis ar arseboba.<br />
4.diagnostikur _ laboratoriuli testebi <strong>da</strong> specialistTa<br />
konsultaciebi<br />
CD3, CD4, CD8 limfocitebis absoluturi ricxvis gansazRvra, <strong>aiv</strong><br />
virusuli <strong>da</strong>tvirTvis gansazRvra polimerizaciis jaWvuri reaqciis<br />
meTodiT, sisxlis saerTo analizi, RviZlis funqciuri sinjebi,<br />
Tirkmlis funqciuri sinjebi, Tavzurgtvinis siTxis aReba <strong>da</strong> naleqis<br />
gamokvleva mikroskopis qveS tuSis wveTis India ink <strong>da</strong>matebis Semdeg an,<br />
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