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4.3. <strong>da</strong>xocili <strong>da</strong> inaqtivirebuli vaqcinebi<br />
<strong>da</strong>xocili <strong>da</strong> inaqtivirebuli vaqcinebi ar warmoadgens safrTxes<br />
imunokompromitirebuli pirebisaTvis <strong>da</strong>, ZiriTa<strong>da</strong>d, gamoiyeneba iseve,<br />
rogorc janmrTel populaciaSi. xSirad imunokompromitirebul<br />
pacientebSi <strong>da</strong>xocili <strong>da</strong> inaqtivirebuli vaqcinis antigenis Sesabamisi<br />
imunuri pasuxi imunokompetentur pirebTan Se<strong>da</strong>rebiT naklebad<br />
srulyofilia; SesaZloa saWiro gaxdes vaqcinaciis maRali doza an<br />
xSiri bustireba, Tumca aRniSnuli modifikaciebis SemTxvevaSic<br />
SesaZloa imunuri pasuxi optimalurze susti iyos (DIV).<br />
4.3.1. qoleris vaqcina (WC/rBs)<br />
Zveli parenteraluri vaqcina (fenoliT inaqtivirebuli <strong>da</strong>xocili<br />
srulujredovani qoleris vibrioni 01) <strong>da</strong>bali efeqturobisa <strong>da</strong><br />
xanmokle <strong>da</strong>cviTi periodis gamo rekomendebuli ar aris, Tumca zogierT<br />
qveyanaSi mainc iwarmoeba.<br />
<strong>da</strong>xocili srulujredovani qoleris vibrionisa <strong>da</strong> qoleris toqsinis<br />
rekombinantuli B fraqciis kombinaciis Semcveli vaqcina (WC/rBs)<br />
usafrTxoa orsulobisa <strong>da</strong> ZuZuTi kvebis periodSic, aseve <strong>aiv</strong> pozitiur<br />
pirebSic.<br />
oraluri vaqcinis 2 doza 10-14 dRis SualediT ainducirebs sawyis<br />
proteqcias vaqcinirebulTa 86%-Si. saSualod vaqcinacia efeqturia 50-<br />
60%-Si sul mcire 3 wlis ganmavlobaSi.<br />
<strong>aiv</strong> pozitiur pirebSi kombinirebuli vaqcinis (WC/rBs) efeqturobis<br />
<strong>da</strong>ma<strong>da</strong>sturebeli specifikuri monacemebi dRemde cnobili ar iyo, Tumca<br />
im populaciis magaliTze, romlis 25%-s <strong>aiv</strong> pozitiuri pirebi<br />
warmoadgendnen, mozambikSi Catarebulma uaxlesma kvlevam gamoavlina<br />
<strong>da</strong>maimedebeli Sedegebi. imunitetis xangrZlivoba <strong>aiv</strong> inficirebulebSi<br />
cnobili ar aris. <strong>aiv</strong> inficirebul mozrdilebSi 100mm 3 -ze naklebi CD4+<br />
ujredebis ricxviT imunizaciis Semdgomi pasuxi SesaZloa iyos susti,<br />
xolo im pirebSi, romelTa CD4+ ujredebis ricxvi 100mm 3 -ze metia<br />
imunuri pasuxi umjobesdeba ori dozis Semdeg. aRniSnuli monacemebi<br />
gviCvenebs vaqcinaciis efeqturobas adreuli an Sualeduri <strong>aiv</strong><br />
<strong>da</strong>avadebisas (DIV).<br />
vaqcinacia seleqtiurad un<strong>da</strong> CautardeT im <strong>aiv</strong> inficirebulebs,<br />
romelTac uwevT mogzauroba endemur kerebSi an miekuTvnebian erT-erT<br />
risk-jgufs (isini vinc xangrZlivi periodiT mogzauroben, iReben<br />
Seumowmebel wyals an arasaTanadod momzadebul sakvebs an cxovroben<br />
arasanitarul pirobebSi <strong>da</strong>avadebis endemur keraSi) (DIV).<br />
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