Gli inibitori del recettore IIb/IIIa - Cuorediverona.it
Gli inibitori del recettore IIb/IIIa - Cuorediverona.it
Gli inibitori del recettore IIb/IIIa - Cuorediverona.it
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Characteristics of GP <strong>IIb</strong>/<strong>IIIa</strong> Inhib<strong>it</strong>ors<br />
Abciximab Eptifibatide Tirofiban<br />
Monoclonal<br />
antibody fragment<br />
Small molecule Small molecule<br />
(KGD sequence) (RGD sequence)<br />
Platelet-Bound Half-life Long (2 hours) Short (secs) Short (secs)<br />
Plasma Half-life Short (mins) Long (2.5 hs) Long (~2 hs)<br />
Drug-to-Receptor Ratio 1.5–2.0 250–2,500* >250 †<br />
% of Dose in Bolus ~75% ‡
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