Her2/neu Il ruolo del Pertuzumab - Università degli Studi di Torino
Her2/neu Il ruolo del Pertuzumab - Università degli Studi di Torino
Her2/neu Il ruolo del Pertuzumab - Università degli Studi di Torino
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Bibliografia<br />
1. Franklin, M. C. et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex.<br />
Cancer Cell 5, 317–328 (2004).<br />
2. Johnson BE et al, Rationale for a phase II trial of pertuzumab, a HER-2 <strong>di</strong>merization inhibitor, in patients<br />
with non-small cell lung cancer, Clin Cancer Res, 14:4436, 2006<br />
3. Adams CW et al, Humanization of a recombinant monoclonal antibody to produce a therapeutic HER<br />
<strong>di</strong>merization inhibitor, pertuzumab, Cancer Immunol Immunother, 55:717, 2005<br />
4. Nahta R et al, The HER-2-targeting antibo<strong>di</strong>es trastuzumab and pertuzumab synergistically inhibit the<br />
survival of breast cancer cells,Cancer Res, 7:2343, 2004<br />
5. Citri A, Yarden Y, EGF-ERBB signalling: towards the systems level, Nat Rev Mol Cell Biol, 7:505,2006<br />
6. Fendly BM et al, Charactirization of murine Monoclonal Antibo<strong>di</strong>es reactive to either the Human Epidermal<br />
Growth Factor Receptor or Her -2/<strong>neu</strong> Gene Product; Cancer Research; 50:1550, 1990<br />
7. Franklin MC et al, Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex,<br />
Cancer Cell, 5:317, 2004<br />
8. Badache A, Hynes NE, A new therapeutic antibody masks ErbB2 to its partners, Cancer Cell, 5:299, 2004<br />
9. Agus DB et al, Phase I clinical study of pertuzumab, a novel HER <strong>di</strong>merization inhibitor, in patients with<br />
advanced cancer, J Clin Oncol, 23:2534, 2005<br />
10. Gordon MS et al, Clinical activity of pertuzumab (rhuMAb 2C4), a HER <strong>di</strong>merization inhibitor, in advanced<br />
ovarian cancer: potential pre<strong>di</strong>ctive relationship with tumor HER2 activation status, J Clin Oncol, 24:4324-<br />
32<br />
11. www.roche-trials.com<br />
12. www.clinicaltrials.gov<br />
13. Agus DB et al, A potential role for activated HER-2 in prostate cancer, Semin Oncol 27:76, 2000<br />
14. Kim HG et al, EGF receptor signaling in prostate morphogenesis and tumorigenesis, Histol Histopathol<br />
14:1175, 1999<br />
15. Maurer CA et al, Increased expression of erbB3 in colorectal cancer is associated with concomitant<br />
increase in the level of erbB2. Hum Pathol, 29:771, 1998
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