LE ARTRITI MICROCRISTALLINE LE ARTRITI ... - WikiMotorio

Pathways involved in MSU crystal-induced
inflammation
MSU-triggered activation of the innate
immune system involves:
1) Recognition of MSU crystals by
components of the innate immune system
2) Uptake of MSU by phagocytotic cells
(e.g. macrophages)
3) Activation of the NLRP3 inflammasome by
MSU
4) Release of IL-1β from the cell.
8
5
Endothelium
7
6 Neutrophil recruitment
Pro-inflammatory mediators release
Busso and So Arthritis Research & Therapy 2010