Dr. Lorenzo Gianni - Oncologia Rimini
Dr. Lorenzo Gianni - Oncologia Rimini
Dr. Lorenzo Gianni - Oncologia Rimini
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Metronomic chemotherapy trials in MBC<br />
Me-CHT OR CR PR SD TTP (m)<br />
Colleoni M. Ann Oncol. 2002<br />
;13(1):73<br />
Burstein SABCS 2005<br />
Orlando L. BMC Cancer. 2006;<br />
6:225<br />
Colleoni M. Ann Oncol. 2006;<br />
17(2):232<br />
CM (63) 19% 3,1% 15,8% 12,7% 2,8<br />
CM (21) 10% 0 10% 38% 2<br />
CM+BV (34) 29% 0% 29% 41% 5,5<br />
CM + Trastuzumab (22) 18% 0% 18% 46% 6<br />
CM (86) 20.9% 3,5% 17,4% 20,9% 3,8<br />
CM + Talidomide (85) 11.8% 3,5% 8,3% 29,4% 4,1<br />
Orlando L. Anticancer <strong>Dr</strong>ugs<br />
2006;17(8):961.<br />
CM (153)<br />
CB > 12 mos: 15,7%, mTTP: 21 mos<br />
Wong NS. JCO 2010; 28(5):723. CM+LMWH+P (51) 17% 2% 15% 7% 10 w<br />
Della Pasqua S.<br />
JCO2008;26(30):4899<br />
García-Sáenz JA. J Chemother<br />
2008;20(5):632.<br />
Licchetta A. J Chemother<br />
2010;22(3):201.<br />
Schott AF. ASCO 2010<br />
CAP 1500/d +CPA 50 mg /d<br />
+ BV10 mg/Kg Q 2w (46)<br />
47,8% 4.3% 43.5% 26.1% 6<br />
CM + BV (24) 31.8% 0% 31.8% 31.8% 7.5<br />
EDX50 + Meg (29) 31.0% NR NR 10.3% 7.4<br />
EDX 100 mg/d 115, CAP<br />
1500x2 821 q21<br />
36% 5% 31% 5,9
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