Rapporto annuale 2007 - Istituto di Ricerche Farmacologiche Mario ...
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Rapporto annuale 2007 - Istituto di Ricerche Farmacologiche Mario ...

Rapporto annuale 2007 - Istituto di Ricerche Farmacologiche Mario ... Rapporto annuale 2007 - Istituto di Ricerche Farmacologiche Mario ...

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IRFMN CONTRIBUTI E CONTRATTI Associazione Progetto Alice ONLUS Comitato Telethon Fondazione ONLUS Commissione Europea FP6 Fondazione Aiuti per la Ricerca sulle Malattie Rare (ARMR) Fondazione ART per la Ricerca sui Trapianti ONLUS Fondazione Cariplo Fondazione La Nuova Speranza – Lotta alla Sclerosi focale ONLUS Fondazione ROTRF/JDRF Istituto Superiore di Sanità ACRAF (Aziende Chimiche Riunite Angelini Francesco Spa) Encysive Farmaceutici Damor Spa Genzyme Corporation Giuliani Spa Novartis Farma Spa Sanofi-Aventis Spa Speedel Pharma Ltd SELEZIONE PUBBLICAZIONI SCIENTIFICHE APPARSE NELL'ANNO 2007 G. Monteferrante, S. Brioschi, J. Caprioli, G. Pianetti, P. Bettinaglio, E. Bresin, G. Remuzzi, M. Noris. Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome. Mol Immunol 2007;44:1704- 1708. S. Heinen, M. Jozsi, A. Hartmann, M. Noris, G. Remuzzi, C. Skerka, P.F. Zipfel. Hemolytic uremic syndrome: a factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells. J Am Soc Nephrol 2007;18:506-514. M. Noris, F. Casiraghi, M. Todeschini, P. Cravedi, D. Cugini, G. Monteferrante, S. Aiello, L. Cassis, E. Gotti, F. Gaspari, D. Cattaneo, N. Perico, G. Remuzzi. Regulatory T cells and T cell depletion: role of immunosuppressive drugs. J Am Soc Nephrol 2007;18:1007-1018. S. Aiello, P. Cassis, L. Cassis, S. Tomasoni, A. Benigni, A. Pezzotta, R.A. Cavinato, D. Cugini, N. Azzollini, M. Mister, L. Longaretti, A.W. Thomson, G. Remuzzi, M. Noris. DnIKK2-transfected dendritic cells induce a novel population of inducible nitric oxide synthase-expressing CD4 + CD25- cells with tolerogenic properties. Transplantation 2007;83:474-484. A. Gianella, E. Nobili, M. Abbate, C. Zoja, P. Gelosa, L. Mussoni, S. Bellosta, M. Canavesi, D. Rottoli, U. Guerrini, M. Brioschi, C. Banfi, E. Tremoli, G. Remuzzi, L. Sironi. Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats. Am J Pathol 2007;170:1165-1177. C. Zoja, F. Casiraghi, S. Conti, D. Corna, D. Rottoli, R.A. Cavinato, G. Remuzzi, A. Benigni. Cyclin-dependent kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus. Arthritis & Rheum 2007;56:1629-1637. A. Benigni, C. Caroli, L. Longaretti, E. Gagliardini, C. Zoja, M. Galbusera, D. Moioli, P. Romagnani, A. Tincani, L. Andreoli, G. Remuzzi. Involvement of renal tubular toll-like receptor 9 in the development of tubulointerstitial injury 259 RAPPORTO ATTIVITA’ 2007

IRFMN in systemic lupus. Arthritis & Rheum 2007;56:1569-1578. N. Perico, M. Abbate, G. Remuzzi. More on renal disease progression: is interstitial inflammation truly protective? (Editorial) J Am Soc Nephrol 2007;18:1630-1632. P. Cravedi, M. Noris, G. Remuzzi. Report of the first World Transplant Congress. (Special Feature) Clin J Am Soc Nephrol 2007;2:393-400. D. Corna, F. Sangalli, D. Cattaneo, F. Carrara, F. Gaspari, A. Remuzzi, C. Zoja, A. Benigni, N. Perico, G. Remuzzi. Effects of rosuvastatin on glomerular capillary size-selectivity function in rats with renal mass ablation. Am J Nephrol 2007;27:630-638. R.A. Cavinato, F. Casiraghi, N. Azzollini, M. Mister, A. Pezzotta, P. Cassis, D. Cugini, N. Perico, G. Remuzzi, M. Noris. Role of thymic- and graft-dependent mechanisms in tolerance induction to rat kidney transplant by donor PBMC infusion. Kidney Int 2007;71:1132-1141. D. Kavanagh, A. Richards, V. Fremeaux-Bacchi, M. Noris, T. Goodship, G. Remuzzi, J.P. Atkinson. Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol 2007;2:591-596. J. Caprioli, G. Remuzzi. Complement hyperactivation may cause atypical haemolytic uraemic syndrome-gain-offunction mutations in factor B. (Editorial) Nephrol Dial Transplant 2007;22:2452-2454. P. Ruggenenti, N. Perico, E. Gotti, P. Cravedi, V. D’Agati, E. Gagliardini, M. Abbate, F. Gaspari, D. Cattaneo, M. Noris, F. Casiraghi, M. Todeschini, D. Cugini, S. Conti, G. Remuzzi. Sirolimus versus cyclosporine therapy increases circulating regulatory T cells, but does not protect renal tranplant patients given alemtuzumbab induction from chronic allograft injury. Transplantation 2007;84:956-964. B. Imberti, M. Morigi, S. Tomasoni, C. Rota, D. Corna, L. Longaretti, D. Rottoli, F. Valsecchi, A. Benigni, J. Wang, M. Abbate, C. Zoja, G. Remuzzi. Insulin-like growth factor-1 sustains stem cell-mediated renal repair. J Am Soc Nephrol 2007;18:2921-2928. E. Gagliardini, A. Benigni. Therapeutic potential of TGF-β inhibition in chronic renal failure. Expert Opin Biol Ther 2007;7:293-304. 260 RAPPORTO ATTIVITA’ 2007

IRFMN<br />

CONTRIBUTI E CONTRATTI<br />

Associazione Progetto Alice ONLUS<br />

Comitato Telethon Fondazione ONLUS<br />

Commissione Europea FP6<br />

Fondazione Aiuti per la Ricerca sulle Malattie Rare (ARMR)<br />

Fondazione ART per la Ricerca sui Trapianti ONLUS<br />

Fondazione Cariplo<br />

Fondazione La Nuova Speranza – Lotta alla Sclerosi focale ONLUS<br />

Fondazione ROTRF/JDRF<br />

<strong>Istituto</strong> Superiore <strong>di</strong> Sanità<br />

ACRAF (Aziende Chimiche Riunite Angelini Francesco Spa)<br />

Encysive<br />

Farmaceutici Damor Spa<br />

Genzyme Corporation<br />

Giuliani Spa<br />

Novartis Farma Spa<br />

Sanofi-Aventis Spa<br />

Speedel Pharma Ltd<br />

SELEZIONE PUBBLICAZIONI SCIENTIFICHE APPARSE<br />

NELL'ANNO <strong>2007</strong><br />

G. Monteferrante, S. Brioschi, J. Caprioli, G. Pianetti, P. Bettinaglio, E. Bresin, G. Remuzzi, M. Noris. Genetic<br />

analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome. Mol Immunol <strong>2007</strong>;44:1704-<br />

1708.<br />

S. Heinen, M. Jozsi, A. Hartmann, M. Noris, G. Remuzzi, C. Skerka, P.F. Zipfel. Hemolytic uremic syndrome: a<br />

factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells. J Am Soc<br />

Nephrol <strong>2007</strong>;18:506-514.<br />

M. Noris, F. Casiraghi, M. Todeschini, P. Crave<strong>di</strong>, D. Cugini, G. Monteferrante, S. Aiello, L. Cassis, E. Gotti, F.<br />

Gaspari, D. Cattaneo, N. Perico, G. Remuzzi. Regulatory T cells and T cell depletion: role of immunosuppressive<br />

drugs. J Am Soc Nephrol <strong>2007</strong>;18:1007-1018.<br />

S. Aiello, P. Cassis, L. Cassis, S. Tomasoni, A. Benigni, A. Pezzotta, R.A. Cavinato, D. Cugini, N. Azzollini, M.<br />

Mister, L. Longaretti, A.W. Thomson, G. Remuzzi, M. Noris. DnIKK2-transfected dendritic cells induce a novel<br />

population of inducible nitric oxide synthase-expressing CD4 + CD25- cells with tolerogenic properties.<br />

Transplantation <strong>2007</strong>;83:474-484.<br />

A. Gianella, E. Nobili, M. Abbate, C. Zoja, P. Gelosa, L. Mussoni, S. Bellosta, M. Canavesi, D. Rottoli, U. Guerrini,<br />

M. Brioschi, C. Banfi, E. Tremoli, G. Remuzzi, L. Sironi. Rosuvastatin treatment prevents progressive kidney<br />

inflammation and fibrosis in stroke-prone rats. Am J Pathol <strong>2007</strong>;170:1165-1177.<br />

C. Zoja, F. Casiraghi, S. Conti, D. Corna, D. Rottoli, R.A. Cavinato, G. Remuzzi, A. Benigni. Cyclin-dependent<br />

kinase inhibition limits glomerulonephritis and extends lifespan of mice with systemic lupus. Arthritis & Rheum<br />

<strong>2007</strong>;56:1629-1637.<br />

A. Benigni, C. Caroli, L. Longaretti, E. Gagliar<strong>di</strong>ni, C. Zoja, M. Galbusera, D. Moioli, P. Romagnani, A. Tincani, L.<br />

Andreoli, G. Remuzzi. Involvement of renal tubular toll-like receptor 9 in the development of tubulointerstitial injury<br />

259<br />

RAPPORTO ATTIVITA’ <strong>2007</strong>

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