271. Genetic polymorhisms of serotonin transporter and monoamine oxidase; and response to SSRI antidepressant drugs in terminal cancer patients Schillani Giulia, Capozzo M., Conte A.M., De Vanna M., Giral<strong>di</strong> T. Department of Biome<strong>di</strong>cal Sciences, University of Triest 272. Lithium response: association study with can<strong>di</strong>date genes Manchia Mirko, Squassina A., Lampus S., Ardau R., Chillotti C., Del Zompo M., Severino G. Section of Clinical Pharmacology, Department of Neurosciences “B.B. Bro<strong>di</strong>e”, University of Cagliari 273. Pharmacogenomics and triptans: a pilot study of association between clinical response to rizatriptan and some can<strong>di</strong>date genes Asuni Carlo, Stochino M.E., Congiu D., Cherchi A., Piccar<strong>di</strong> M. P., Del Zompo M. Headache Centre, Section of Clinical Pharmacology, Department of Neurosciences “B.B. Bro<strong>di</strong>e”, University of Cagliari 274. Synergistic cytotoxicity of oxaliplatin and pemetrexed in colon cancer cells: cellular and molecular mechanisms Nannizzi Sara, Giovannetti E., Mey V., Ricciar<strong>di</strong> S., Del Tacca M., Danesi R. Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of Pisa 275. Molecular mechanisms underlying the synergistic interaction of the EGFR tyrosine kinase inhibitor erlotinib with the multitargeted antifolate pemetrexed in non-small cell lung cancer cells Giovannetti Elisa 1,2 , Smid K. 1 , Mey V. 2 , Tekle C. 1 , Nannizzi S. 2 , Rodriguez J.A 1 , Ricciar<strong>di</strong> S. 2 , Del Tacca M. 2 , Giaccone G. 1 , Danesi R. 2 , Peters Godefridus J 1 1 Dept. Me<strong>di</strong>cal Oncology, VU University Me<strong>di</strong>cal Center, Amsterdam, The Netherlands; 2 Dept. Internal Me<strong>di</strong>cine, Div. Pharmacology and Chemotherapy, University of Pisa, Italy 147 276. Pharmacogenetic evaluation of Aurora A kinase in colorectal cancers Amatori Federica Maria*, Boldrini L § , Di Paolo A*, Lastella M*, Fontanini G § , Del Tacca M*, Danesi R*. *Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine; § Division of Pathology, Department of General Surgery, University of Pisa 277. Epigenetic mechanisms of sensitivity to irinotecan in colorectal cancer cell lines Crea Francesco, Giovannetti E., Mey V., Nannizzi S., Ricciar<strong>di</strong> S., Danesi R., Del Tacca M. Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of Pisa, Pisa, Italy 278. Genetic polymorphisms in DNA repair genes and their impact on susceptibility to multiple myeloma Angelini Sabrina 1 , Cantelli-Forti G. 1 , Terragna C. 2 , Renzulli M. 2 , Cavo M. 2 , Hrelia P. 1 1 Department of Pharmacology, University of Bologna; 2 Institute of Haematology and Me<strong>di</strong>cal Oncology “Seragnoli”, University of Bologna 279. Genetic polymorphism of bleomycin hydrolase: a new biomarker for human mutagen sensitivity Maffei Francesca 1 , Carbone F. 1 , Angelini S. 1 , Cantelli Forti G. 1 , Norppa Hannu 2 , Hrelia P. 1 1 Department of Pharmacology, University of Bologna, Via Irnerio 48 40126 Bologna, Italy; 2 Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FI-00250 Helsinki, Finland pag_dx.indd 1 30/05/2007 6.02.14
280. DNA vaccine strategy against chronic B-cell lymphoma: anti-i<strong>di</strong>otypic CDR3 vaccination Schirru Cristina 1 , Maullu C. 1 , Deidda F. 1 , Rinal<strong>di</strong> M. 3 , Signori E. 2,3 , Massi E. 2 , Chiarella P. 1,2 , Marelli O. 4 , Tonon G. 1 , Fazio V.M. 2,3 1 Bioker S.r.l. Polaris Loc.piscinamanna Pula (CA); 2 CIR, Section of Molecular Me<strong>di</strong>cine and Biotechnology, University "Campus Bio-Me<strong>di</strong>co", Rome, Italy; 3 Institute of Neurobiology and Molecular Me<strong>di</strong>cine, CNR Rome, Italy; 4 Dipartimento Di Farmacologia, Chemioterapia E Tossicologia Me<strong>di</strong>ca, Università <strong>di</strong> Milano 148 pag_sx.indd 1 30/05/2007 6.03.02
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