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Wyeth:<br />

la ricerca<br />

nasce qui<br />

●<br />

Aprilia<br />

Sede legale<br />

Stabilimento Produzione Farmaceutica<br />

●<br />

Catania<br />

Stabilimento Produzione Farmaceutica<br />

Agricoltura Veterinaria<br />

Centro Ricerche:<br />

- Wyeth European Drug Safety and Metabolism Center<br />

La cultura della salute<br />

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38<br />

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Cre<strong>di</strong>ti ECM assegnati 5<br />

Corso <strong>di</strong> Aggiornamento<br />

Il contributo della farmacologia al trattamento della depressione<br />

SALA 5<br />

09.00-17.00<br />

Moderatori: Carpiniello B (Cagliari) Putzu P (Cagliari)<br />

26<br />

09.00/09.15 Carpiniello B (Cagliari)<br />

Apertura e introduzione<br />

09.15/10.00 Guazzelli M (Pisa)<br />

Diagnosi e classificazione dei <strong>di</strong>sturbi depressivi: vali<strong>di</strong>tà e limiti<br />

dell'approccio clinico-descrittivo<br />

10.00/10.45 Sorbi S (Firenze)<br />

Depressione in corso <strong>di</strong> malattie neurologiche: fattore negativo per la<br />

prognosi?<br />

11.15/12.00 Biggio G (Cagliari)<br />

Presente e futuro <strong>degli</strong> antidepressivi<br />

12.00/12.30 Discussione<br />

12.30/13.00 Workshop<br />

Guazzelli M (Pisa)<br />

Presentazione caso clinico A<br />

Sorbi S (Firenze)<br />

Presentazione caso clinico B<br />

14.00/15.00 Guazzelli M (Pisa) Carpiniello B (Cagliari)<br />

Elaborazione del caso clinico<br />

15.00/16.00 Sorbi M (Firenze) Putzu P (Cagliari)<br />

Presentazione del caso clinico<br />

16.30/17.00 Putzu P (Cagliari)<br />

Conclusioni e questionario ECM<br />

Realizzato con il contributo educazionale <strong>di</strong> Lundbeck<br />

pag_sx.indd 1 29/05/2007 23.41.25


Cerimonia Inaugurale<br />

AUDITORIUM<br />

18.00-19.00<br />

Saluto delle Autorità<br />

Lettura Inaugurale<br />

Moderatore : Biggio G (Cagliari)<br />

Sessione ECM<br />

Hokfelt T (Karolinska Institute, Stockholm)<br />

Three decades with three Swe<strong>di</strong>sh neuropeptides: focus on pain and depression<br />

AUDITORIUM<br />

19.00-20.00<br />

Cocktail <strong>di</strong> Benvenuto<br />

20.00-22.00<br />

27<br />

pag_dx.indd 1 29/05/2007 23.47.24


28<br />

Simposio<br />

Vecchi e nuovi antipsicotici a confronto<br />

(<strong>SIF</strong> - SINPF)<br />

Moderatori: Nivoli G (Sassari) Racagni G (Milano)<br />

08.30/08.50 Riva MA (Milano)<br />

Diversità dei meccanismi d'azione<br />

08.50/09.10 Altamura CA (Milano)<br />

Il trattamento acuto<br />

09.10/09.30 Bellantuono C (Verona)<br />

Il trattamento cronico<br />

09.30/09.50 Mencacci C (Milano)<br />

Antipsicotici e genere<br />

09.50/10.10 Aguglia E (Trieste)<br />

I farmaci antipsicotici nel BPSD<br />

10.10/10.30 Balestrieri M (U<strong>di</strong>ne)<br />

Antipiscotici e <strong>di</strong>sturbi <strong>di</strong> personalità<br />

10.30/10.45 Discussione<br />

10.45/11.00 Nivoli G (Sassari)<br />

Conclusioni<br />

Sessione ECM<br />

Cre<strong>di</strong>ti ECM assegnati 4<br />

Simposio<br />

Modulazione farmacologica dei recettori P 1<br />

(<strong>SIF</strong> - Gruppo Nazionale Adenosina)<br />

Moderatori: Borea PA (Ferrara) Caciagli F (Chieti)<br />

08.30/08.50 Baral<strong>di</strong> PG (Ferrara)<br />

Nuovi agonisti e antagonisti del recettore adenosinico A 2B<br />

AUDITORIUM<br />

08.30-11.00<br />

SALA 1<br />

08.30-11.00<br />

08.50/09.10 Popoli P (Roma)<br />

Ruolo dei recettori A 2A dell'adenosina nella modulazione <strong>di</strong> effetti neurotrofici in<br />

con<strong>di</strong>zioni fisiologiche e patologiche<br />

09.10/09.30 Melani A (Firenze)<br />

Neuroprotezione <strong>degli</strong> antagonisti A 2A durante ischemia<br />

09.30/09.50 Martini C (Pisa)<br />

Interazione funzionale tra recettori dell'adenosina e recettori dopaminergici: ruolo<br />

nella terapia antipsicotica<br />

09.50/10.10 Carta A (Cagliari)<br />

Antagonisti per i recettori A 2A adenosinergici: una promettente terapia sintomatica e<br />

neuroprotettiva per la malattia <strong>di</strong> Parkinson<br />

10.10/10.30 Varani K (Ferrara)<br />

Alterazione dei recettori dell'adenosina in pazienti con broncopneumopatia cronica<br />

ostruttiva<br />

10.30/10.50 Capecchi PL (Siena)<br />

Sistema adenosinergico e polimorfismi genetici: possibili implicazioni cliniche in<br />

ambito car<strong>di</strong>ovascolare<br />

10.50/11.00 Discussione<br />

pag_sx.indd 1 01/06/2007 14.56.01


Sessione ECM<br />

Simposio<br />

Efficacia e sicurezza <strong>di</strong> FANS tra<strong>di</strong>zionali e COXIB<br />

Moderatori: Mugelli A (Firenze) Patrono C (Roma)<br />

08.30/08.50 Patrono C (Roma)<br />

Farmacologia clinica <strong>degli</strong> inibitori delle ciclo-ossigenasi<br />

08.50/09.10 Lanas A (Saragoza)<br />

Clinical consequences of cyclooxygenase inhibition on the upper and lower<br />

gastrointestinal tract<br />

SALA 2<br />

08.30-11.00<br />

09.10/09.30 Baigent C (Oxford)<br />

Risk of myocar<strong>di</strong>al infarction, stroke and vascular death associated with coxibs and<br />

tra<strong>di</strong>tional NSAIDs<br />

09.30/11.00 Tavola Rotonda<br />

Quesiti aperti e priorità in tema <strong>di</strong> ricerca clinica e <strong>di</strong> scelte terapeutiche<br />

Simposio<br />

<strong>SIF</strong> e informazione in<strong>di</strong>pendente sul farmaco<br />

(Sezione <strong>di</strong> Farmacologia Clinica)<br />

Moderatori: Caputi AP (Messina) Velo GP (Verona)<br />

08.30/08.50 Ad<strong>di</strong>s A (Roma)<br />

L'Agenzia del Farmaco<br />

08.50/09.05 Moretti U (Verona)<br />

Focus (ISBD)<br />

Sessione ECM<br />

09.05/09.20 Polimeni G (Messina)<br />

www.farmacovigilanza.org: portale sulla farmacovigilanza<br />

09.20/09.35 Moschini M (Firenze) Vannacci A (Firenze) Tuccori M (Pisa)<br />

Segnalazione spontanea <strong>di</strong> ADR ed informazione <strong>di</strong> ritorno in Toscana<br />

09.35/09.50 Filippelli A (Napoli)<br />

L'esperienza del Centro Regionale <strong>di</strong> Farmacovigilanza della Campania<br />

09.50/10.05 Del Zompo M (Cagliari)<br />

La farmacologia <strong>di</strong> consultazione in Sardegna<br />

10.05/10.20 Tragni E (Milano)<br />

SEFAPNEWS<br />

10.20/10.40 Font M (Verona)<br />

Dialogo sui farmaci<br />

10.40/11.00 Discussione generale<br />

SALA 3<br />

08.30-11.00<br />

29<br />

pag_dx.indd 1 30/05/2007 0.53.23


Sessione ECM<br />

Simposio<br />

Dalle scienze <strong>di</strong> base alla scoperta <strong>di</strong> nuove terapie per l'epilessia<br />

(<strong>SIF</strong> - LICE)<br />

Moderatori: Perucca E (Pavia) De Sarro G (Catanzaro) Marrosu F (Cagliari)<br />

SALA 4<br />

08.30-11.00<br />

08.30/08.50 De Sarro G (Catanzaro)<br />

Gli attuali modelli sperimentali <strong>di</strong> epilessia sono appropriati per in<strong>di</strong>viduare nuovi<br />

agenti antiepilettici?<br />

08.50/09.10 Marrosu F (Cagliari)<br />

Meccanismi molecolari attivati dalla stimolazione vagale<br />

09.10/09.30 Simonato M (Ferrara)<br />

Fattori neurotrofici veicolati da vettori virali: un nuovo approccio?<br />

09.30/09.50 Perucca E (Pavia)<br />

Nuove molecole in sviluppo clinico: una visitazione critica<br />

09.50/10.10 Spina E (Messina)<br />

Utilità dei farmaci antiepilettici in altre in<strong>di</strong>cazioni terapeutiche: esperienze e<br />

prospettive<br />

10.10/11.00 Discussione<br />

30<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Farmacologia delle sostanze d'abuso<br />

Moderatori: Bertolini A (Modena) Cuomo V (Roma)<br />

SALA 5<br />

08.30-11.30<br />

Genedani Susanna 1 , Agnati L.F. 1 , Filaferro M. 1 , Carone C. 1 , Guidolin D. 2 , Roberts D.C.S. 3 ,<br />

Marcellino D. 4 , Fuxe K. 4<br />

1 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena; 2 Dipartimento<br />

<strong>di</strong> Anatomia e Fisiologia Umana, Università <strong>di</strong> Padova; 3 Department of Physiology and Pharmacology,<br />

Wake Forest University School of Me<strong>di</strong>cine, Winston-Salem, USA; 4 Department of Neuroscience,<br />

Karolinska Institutet, Stockholm, Sweden<br />

Influenza della cocaina sui recettori A2A e D2: stu<strong>di</strong> in vivo e in vitro.<br />

Fattore Liana 1,3 , Pons S. 4 , Cossu G. 2,3 , Tolu S. 4 , Porcu E. 2 , Changeux J-P. 4 , Fratta W. 1,2,3 ,<br />

Maskos U. 4<br />

1 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari; 2 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong><br />

Cagliari; 3 Centro <strong>di</strong> Eccellenza "Neurobiologia delle Dipendenze", Università <strong>di</strong> Cagliari; 4 Unité<br />

Récepteurs et Cognition, URA CNRS 2182, Institut Pasteur, Paris Cedex 15, France<br />

Le subunità beta-2 e alfa-4, ma non alfa-7, del recettore nicotinico nella VTA sono necessarie e<br />

sufficienti per il rinforzo da nicotina.<br />

Fadda Paola 1,2 , Spano M.S. 1,2 , Cossu G. 1,2 , Fattore L. 2,3 , Fratta W. 1,2,3<br />

1 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari e 2 Centro <strong>di</strong> Eccellenza "Neurobiologia delle<br />

Dipendenze", Università <strong>di</strong> Cagliari; 3 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari<br />

L’agonista GABA B baclofen previene le ricadute all’abuso <strong>di</strong> sostanze: evidenze precliniche.<br />

Mostallino Maria Cristina1, Mura M.L. 2 , Maciocco E. 2 , Murru L., Sanna E. 2,3 , Biggio G.<br />

1 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari; 2 Dipartimento <strong>di</strong> Biologia Sperimentale sezione<br />

Neuroscienze, Università <strong>di</strong> Cagliari; 3 Centro <strong>di</strong> Eccellenza "Neurobiologia delle Dipendenze",<br />

Università <strong>di</strong> Cagliari<br />

Astinenza da etanolo e plasticità del recettore GABA A.<br />

pag_sx.indd 1 04/06/2007 11.35.27


Tacchi Raffaella 1 , Vergoni A.V. 3 , Tosi G. 4 , Costantino L. 4 , Rivasi F. 2 , Bertolini A. 1 , Ruozzi B. 4 ,<br />

Forni F. 4 , Vandelli M.A. 4<br />

1 Struttura Complessa <strong>di</strong> Tossicologia e Farmacologia Clinica; 2 Sezione <strong>di</strong> Anatomia Patologica;<br />

3 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia;<br />

4 Dipartimento <strong>di</strong> Scienze<br />

Farmaceutiche, Università <strong>di</strong> Modena e Reggio Emilia<br />

Nanoparticelle polimeriche coniugate con un glico-eptapeptide come trasportatori <strong>di</strong> farmaci<br />

all'interno del sistema nervoso centrale.<br />

Solinas Marcello 1,2 , Scherma M. 2,3 , Fattore L. 4 , Stroik J. 2 , Wertheim C.E. 2 , Tanda G. 2 , Fratta<br />

W. 3 , Goldberg S.R. 2<br />

1 IBPC, CNRS-6187, University of Poitiers, France; 2 NIDA, NIH, DHHS, USA; 4 Dipartimento <strong>di</strong><br />

Neuroscienze, Università of Cagliari; 5 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari<br />

I recettori nicotinici come nuovi targets per il trattamento dell’abuso <strong>di</strong> cannabis.<br />

Pistis Marco 1 , Pillolla G. 1 , Perra S.Z., Melis M. 1 , Muntoni A.L. 2<br />

1 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari; 2 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong><br />

Cagliari<br />

La stimolazione del me<strong>di</strong>al forebrain bundle induce mo<strong>di</strong>ficazioni a breve e a lungo termine<br />

nell’attività dei neuroni dopaminergici: coinvolgimento dei recettori cannabinoide e glutamatergico.<br />

Viganò Daniela G., Guidali C., Rubino T., Parolaro D.<br />

DBSF, Università dell’Insubria (VA)<br />

Ruolo del sistema recettoriale cannabico in un modello farmacologico <strong>di</strong> schizofrenia.<br />

Trezza Viviana 1 , Cuomo V. 2 , Vanderschuren L.J.M.J. 1<br />

1 Dept. Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Me<strong>di</strong>cal<br />

Center Utrecht, Utrecht, The Netherlands; 2 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia,<br />

Università <strong>di</strong> Roma “La Sapienza”<br />

Farmaci attivi sul sistema cannabinoide: effetti prosociali e antisociali in ratti Wistar adolescenti.<br />

31<br />

Castaldo Pasqualina 1 , Magi S. 1 , Gaetani S. 2 , Cassano T. 3 , Ferraro L. 4 , Corcione E. 1 , Antonelli<br />

T. 4 , Cuomo V. 2 , Amoroso S. 1<br />

1 Sezione <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Neuroscienze, Università “Politecnica delle Marche”,<br />

Ancona; 2 Dipartimento <strong>di</strong> Farmacologia e Fisiologia umana Università <strong>di</strong> Roma “La Sapienza”;<br />

3 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che Università <strong>di</strong> Foggia; 4 Sezione <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong><br />

Me<strong>di</strong>cina Clinica e Sperimentale, Università <strong>di</strong> Ferrara<br />

L’esposizione prenatale all’agonista del recettore per i cannabinoi<strong>di</strong> WIN 55,212-2 riduce l’efflusso ed<br />

aumenta la ricaptazione <strong>di</strong> glutammato attraverso una sovraespressione dei trasportatori del<br />

glutammato glt1 ed eaac1 nella corteccia prefrontale <strong>di</strong> ratto.<br />

pag_dx.indd 1 30/05/2007 0.56.43


Simposio<br />

Asma e patologie correlate<br />

Moderatori: Rossi F (Napoli) Cirino G (Napoli)<br />

Sessione ECM<br />

08.30/08.50 Fabbri LM (Modena)<br />

Asma e BPCO: storia naturale <strong>di</strong> asma e BPCO (implicazioni terapeutiche)<br />

08.50/09.10 Brusasco V (Genova)<br />

Asma e rinite: due fenotipi dell'allergopatia respiratoria<br />

09.10/09.30 Di Maria G (Catania)<br />

Asma e apnea notturna: strategie per migliorare la vita dei pazienti<br />

09.30/09.50 Scaglione F (Milano)<br />

Asma e infezioni: relativi trattamenti appropriati<br />

09.50/10.10 Polverino M (Salerno)<br />

Asma e obesità: BMI e asma<br />

10.10/10.30 D'Agostino B (Napoli)<br />

Asma e reflusso gastroesofageo: ruolo delle fibre C (modelli animali)<br />

10.30/11.00 Discussione<br />

SALA 6<br />

08.30-11.00<br />

32<br />

Realizzato con il contributo educazionale <strong>di</strong> AstraZeneca<br />

Sessione ECM<br />

Simposio<br />

Modulazione farmacologica dell'infiammazione polmonare nella<br />

broncopneumopatia cronica ostruttiva<br />

Moderatori: Barnes PJ (Londra) Montuschi P (Roma)<br />

08.30/08.55 Folco G (Milano)<br />

Basi fisiopatologiche della broncopneumopatia cronica ostruttiva<br />

08.55/09.20 Geppetti P (Firenze)<br />

Canali TPR e patologia respiratoria<br />

09.20/09.45 Fabbri L (Modena)<br />

La terapia farmacologica della broncopneumopatia cronica ostruttiva<br />

SALA 7<br />

08.30-11.00<br />

09.45/10.10 Barnes PJ (Londra)<br />

Nuove strategie farmacoterapeutiche per la broncopneumopatia cronica ostruttiva<br />

10.10/10.35 Montuschi P (Roma)<br />

Meto<strong>di</strong>che non invasive nel monitoraggio dell'infiammazione polmonare e della terapia<br />

farmacologica nella broncopneumopatia cronica ostruttiva<br />

10.35/11.00 Discussione<br />

Realizzato con il contributo educazionale <strong>di</strong> Altana<br />

pag_sx.indd 1 30/05/2007 0.58.37


Sessione ECM<br />

Simposio<br />

Key research strategies in pharmacology: how to take water into<br />

dry pipe-lines<br />

(<strong>SIF</strong> - EPHAR)<br />

Moderatori: Weston A (Manchester) Drago F (Catania)<br />

08.30/08.55 Brunello N (Milano)<br />

Are anti-inflammatory drugs the antidepressants of the future?<br />

SALA 8<br />

08.30-11.00<br />

08.55/09.20 Edwards G (Manchester)<br />

Ca 2+ -sensing receptors in blood vessels: potential new targets in vascular <strong>di</strong>sease<br />

09.20/09.45 Buckingham J (Londra)<br />

Glucocorticoids: exemplars of multi-tasking<br />

09.45/10.10 Smits J (Maastricht)<br />

Molecular imaging of ischemic heart <strong>di</strong>sease: new pharmacological targets<br />

10.10/10.35 Sebastiao A (Lisbona)<br />

Adenosine receptors in neuroprotection<br />

10.35/11.00 Discussione<br />

Pausa caffè<br />

11.00-11.30<br />

33<br />

Lettura Plenaria<br />

Moderatore: Fratta W (Cagliari)<br />

Santarelli L (Palo Alto, USA)<br />

Ruolo funzionale della neurogenesi nell’adulto<br />

AUDITORIUM<br />

11.30-12.30<br />

Sessione Poster<br />

12.30-15.00<br />

Colazione <strong>di</strong> lavoro<br />

12.30-13.30<br />

Incontro con l’Esperto<br />

Moderatore: Fratta W (Cagliari)<br />

Grassi MC (Roma)<br />

La Vareniclina: nuove prospettive nella terapia del tabagismo<br />

Realizzato con il contributo educazionale <strong>di</strong> Pfizer<br />

SALA 4<br />

14.00-15.00<br />

pag_dx.indd 1 30/05/2007 1.09.57


Incontro con l'Esperto<br />

Moderatore: Scaglione F (Milano)<br />

Mazzei T (Firenze)<br />

Ricerca e sviluppo in antibioticoterapia: a che punto siamo?<br />

SALA 5<br />

14.00-15.00<br />

34<br />

Sessione ECM<br />

Simposio<br />

Nuove acquisizioni nella ricerca sui cannabinoi<strong>di</strong><br />

Moderatori: Fratta W (Cagliari) Parolaro D (Varese)<br />

15.00/15.20 Piomelli D (Irvine)<br />

Il sistema endocannabinoide alla soglia della terapia<br />

AUDITORIUM<br />

15.00-17.30<br />

15.20/15.40 Le Fur G (Parigi)<br />

Il ruolo del Rimonabant, un antagonista dei recettori CB 1 , nel trattamento dell'obesità<br />

e dei fattori <strong>di</strong> rischio car<strong>di</strong>ometabolici associati<br />

15.40/16.00 Di Marzo V (Napoli)<br />

Il sistema endocannabinoide nelle malattie neurodegenerative e nel dolore<br />

neuropatico<br />

16.00/16.20 Cuomo V (Roma)<br />

Un'alterata neurogenesi dei neuroni ippocampali è associata a deficit funzionali<br />

osservati nei ratti adulti esposti nel periodo prenatale ai cannabinoi<strong>di</strong><br />

16.20/16.40 Parolaro D (Varese)<br />

Il trattamento cronico con THC durante il periodo adolescenziale induce mo<strong>di</strong>ficazioni<br />

neurobiologiche <strong>di</strong> lunga durata nell'adulto<br />

16.40/17.00 Fratta W (Cagliari)<br />

Possibile ruolo del sistema endocannabinoide nelle reci<strong>di</strong>ve all'abuso <strong>di</strong> sostanze<br />

17.00/17.30 Discussione<br />

Realizzato con il contributo educazionale <strong>di</strong> Sanofi Aventis Recherce & Dev.<br />

pag_sx.indd 1 30/05/2007 1.12.14


Cre<strong>di</strong>ti ECM assegnati 4<br />

Simposio<br />

Modulazione farmacologica dei recettori P 2<br />

(<strong>SIF</strong> - Gruppo Nazionale Adenosina)<br />

Moderatori: Abbracchio MP (Milano) Pedata F (Firenze)<br />

15.00/15.15 Volpini R (Trieste)<br />

Progettazione e sintesi <strong>di</strong> nuovi ligan<strong>di</strong> dei recettori P 2<br />

SALA 1<br />

15.00-17.30<br />

15.15/15.30 Ferrari D (Ferrara)<br />

L'antibiotico polymyxina B è un potente modulatore allosterico del recettore P 2X7<br />

15.30/15.45 Verderio C (Milano)<br />

Ruolo del recettore P 2X7 nella funzione microgliale<br />

15.45/16.00 Volontè C (Roma)<br />

Recettori purinergici P 2 : nuove tendenze nel sistema nervoso centrale<br />

16.00/16.15 Ceruti S (Milano)<br />

ATP come molecola <strong>di</strong> segnalazione nel dolore trigeminale<br />

16.15/16.30 Pugliese AM (Firenze)<br />

Ruolo <strong>di</strong> ATP e dei recettori P 2 purinergici nella trasmissione sinaptica della regione<br />

CA1 <strong>di</strong> ippocampo <strong>di</strong> ratto sia in con<strong>di</strong>zioni normossiche che durante deprivazione <strong>di</strong><br />

ossigeno e glucosio<br />

16.30/16.45 Trincavelli ML (Pisa)<br />

Localizzazione dei recettori A1 e P 2Y1 nell'ippocampo e loro interazione funzionale<br />

16.45/17.00 Ballerini P (Chieti)<br />

Ruolo delle proteine ABC nella produzione me<strong>di</strong>ata dalle purine <strong>di</strong> fattori coinvolti<br />

nella fisiopatologia dell'aterosclerosi<br />

17.00/17.30 Questionario ECM<br />

35<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Giovani Farmacologi<br />

SALA 2<br />

15.00-20.00<br />

Moderatori: Concas A (Cagliari) Brunelleschi S (Novara) De Sarro A (Messina)<br />

Gunella Gabriele, Bardelli C., Amoruso A., Fresu L.G., Zeppegno P., Brunelleschi S.<br />

Dipartimento Scienze Me<strong>di</strong>che, Università del Piemonte Orientale “A.Avogadro”, Novara<br />

Sostanza P e Depressione: espressione del recettore NK1, attivazione <strong>di</strong> NF-B e rilascio <strong>di</strong> citochine<br />

in monociti <strong>di</strong> pazienti psichiatrici.<br />

Soldovieri Virginia 1 , Cilio M.R. 2 , Miceli F. 1 , Bellini G. 3 , Castaldo P. 1 , Shapiro M.S. 4 , Pascotto<br />

A. 3 , Annunziato L. 1 , Taglialatela M. 1,5<br />

1 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Napoli “Federico II”; 2 Dipartimento <strong>di</strong> Neurologia<br />

Infantile, Ospedale Pe<strong>di</strong>atrico “Bambin Gesù” <strong>di</strong> Roma; 3 Cattedra <strong>di</strong> Neuropsichiatria Infantile,<br />

Seconda Università <strong>di</strong> Napoli; 4 Dipartimento <strong>di</strong> Fisiologia, Centro <strong>di</strong> Scienze del Benessere,<br />

Università del Texas, San Antonio, USA; 5 Università del Molise, Campobasso<br />

Nuove mutazioni responsabili <strong>di</strong> convulsioni benigne familiari neonatali alterano aminoaci<strong>di</strong> non<br />

carichi del segmento S4 delle subunità dei canali del potassio KCNQ2 e riducono la funzionalità della<br />

corrente Ikm me<strong>di</strong>ante alterazioni delle proprietà <strong>di</strong> apertura.<br />

pag_dx.indd 1 30/05/2007 1.15.35


DiPalma Antonella, Desaphy J-F., Conte Camerino D.<br />

Dipartimento Farmaco-Biologico, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Bari<br />

L’orfenadrina blocca i canali al so<strong>di</strong>o voltaggio-<strong>di</strong>pendenti attraverso il legame al recettore <strong>degli</strong><br />

anestetici locali.<br />

Lintas Alessandra, Panin F., Diana M.<br />

“G. Minar<strong>di</strong>” Laboratory of Cognitive Neuroscience, Dipartimento <strong>di</strong> Scienze del Farmaco, Università<br />

<strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Sassari<br />

L’aumentata eccitabilità dei MSN del Nucleus Accumbens nell’astinenza da morfina.<br />

Pisu Maria Giuseppina 1 , Dore R. 3 , Biggio G. 1,2,3 , Serra M. 1,2,3<br />

1 CNR Istituto <strong>di</strong> Neuroscienze, Sezione <strong>di</strong> Cagliari; 2 Centro <strong>di</strong> Eccellenza per la Neurobiologia delle<br />

Dipendenze, 3 Dipartimento <strong>di</strong> Biologia Sperimentale, Sezione <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari<br />

Effetto dell’etanolo nei ratti socialmente isolati: <strong>di</strong>fferenze <strong>di</strong> genere.<br />

Coluccia Addolorata, Belfiore D., Borracci P., Renna G., Giustino A., Carratù M.R.<br />

Dipartimento <strong>di</strong> Farmacologia e Fisiologia Umana, Università <strong>di</strong> Bari<br />

Esposizione ad acido retinoico durante la gravidanza: alterazioni neurofunzionali nella progenie<br />

maschile e femminile <strong>di</strong> ratto.<br />

36<br />

Grilli Massimo 1 , Patti L. 1 , Robino F. 1 , Zappettini S. 1 , Sofianos I. 1 , Raiteri M. 1,2 , Marchi M. 1,2<br />

1 Sezione <strong>di</strong> Farmacologia e Tossicologia, Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Università <strong>di</strong><br />

Genova; 2 Centro <strong>di</strong> Eccellenza per la Ricerca Biome<strong>di</strong>ca, Università <strong>di</strong> Genova<br />

Coesistenza e interazione funzionale tra recettori presinaptici nicotinici e muscarinici che modulano il<br />

rilascio <strong>di</strong> neurotrasmettitori da sinaptosomi striatali.<br />

Carta Mario, Murru L., Barabino E., Botta P., Talani G., Zaccheddu R., Sanna E.,<br />

Biggio G.<br />

Dip. Di Biologia Sperimentale, Sezione Neuroscienze e Centro <strong>di</strong> Eccellenza per la Neurobiologia delle<br />

Dipendenze, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Cagliari<br />

Uso dell’isoniazide, un inibitore dell'acido glutammico decarbossilasi, per lo stu<strong>di</strong>o in vitro del ruolo<br />

della trasmissione GABAergica nel controllo del circuito neuronale della corteccia cerebellare<br />

Leggio Gian Marco, Consoli D., Mazzola C., Micale V., Drago F.<br />

Dipartimento <strong>di</strong> Farmacologia Sperimentale e Clinica, Università <strong>di</strong> Catania<br />

Effetti comportamentali dell’agonista del recettore 3 adrenocettore sr58611a: prototipo <strong>di</strong> una<br />

nuova classe <strong>di</strong> farmaci antidepressivi/ansiolitici?<br />

Rocchitta Gaia 1 , Puggioni G. 1 , Dedola S. 1 , Bazzu G. 1 , Lowry J.P. 2 , O’Neill R.D. 3 , Serra P.A. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Sassari; 2 Department of Chemistry, National University o<br />

Ireland, Maynooth, Co. Kildare, Ireland; 3 UCD School of Chemistry and Chemical Biology, University<br />

College Dublin, Belfield, Dublin 4, Ireland.<br />

Sviluppo <strong>di</strong> un nuovo sistema biotelemetrico per il monitoraggio in tempo reale <strong>di</strong> nitrossido,<br />

glutammato e acido ascorbico nello striato <strong>di</strong> ratti freely moving.<br />

17.15 – 17.30 INTERVALLO<br />

pag_sx.indd 1 30/05/2007 1.18.57


Moderatori: Taglialatela M (Campobasso) Amoroso S (Ancona) Guarini S (Modena)<br />

Simioni Carolina 1 , Merighi S. 1 , Benini A. 1 , Mirandola P. 2 , Gessi S. 1 , Varani K. 1 , Leung E. 3 ,<br />

Maclennan S. 3 , Baral<strong>di</strong> P.G. 4 , Borea P.A. 1<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale Sez. Farmacologia, Università <strong>di</strong> Ferrara; 2 Dip. Di<br />

Anatomia Umana, Farmacologia e Me<strong>di</strong>cina Forense, Ist. Di Anatomia Umana, Osp. Maggiore,<br />

Università <strong>di</strong> Parma; 3 King Pharm. Res. and Dev., Inc., Cary, North Carolina, 4 Dipartimento <strong>di</strong><br />

Scienze Farmaceutiche, Università <strong>di</strong> Ferrara.<br />

L’ipossia inibisce l’apoptosi indotta da paclitaxel me<strong>di</strong>ante la fosforilazione <strong>di</strong> BAD <strong>di</strong>pendente<br />

dall’adenosina nelle cellule <strong>di</strong> glioblastoma.<br />

Poma Paola, Labbozzetta M., Notarbartolo M.,Maurici A., Rizzi M. * , Simoni D. * ,D’Alessandro<br />

N.<br />

Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Palermo e *Dipartimento <strong>di</strong> Scienze<br />

Farmaceutiche, Università <strong>di</strong> Ferrara<br />

Le attività antitumorali della curcumina e del suo nuovo analogo isossazolico MR 39 non vengono<br />

ostacolate dalla con<strong>di</strong>zione <strong>di</strong> multifarmacoresistenza <strong>di</strong> cellule tumorali che esprimono sia la P-<br />

glicoproteina che <strong>di</strong>fferenti IAP.<br />

Menna Pierantonio, Salvatorelli E., Minotti G.<br />

Dipartimento Scienze del Farmaco - Centro Scienze dell’ Invecchiamento, Università “G.d’Annunzio”,<br />

Chieti<br />

Distribuzione, metabolismo e tossicità della doxorubicina in car<strong>di</strong>omiociti: Ruolo della mioglobina.<br />

Salvatorelli Emanuela, Menna P., Minotti G.<br />

Dipartimento Scienze del Farmaco - Centro Scienze dell’ Invecchiamento, Università “G.d’Annunzio”,<br />

Chieti<br />

Sviluppo <strong>di</strong> un modello traslazionale <strong>di</strong> cuore umano per lo stu<strong>di</strong>o <strong>di</strong> interazioni tossico-metaboliche<br />

tra doxorubicina o epirubicina e paclitaxel o docetaxel.<br />

37<br />

Tramentozzi Elisa 1 , Pagetta A. 1 , Monopoli M. 1 , Frasson M. 2 , Finotti P. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia e Anestesiologia, Università <strong>di</strong> Padova; 2 Dipartimento <strong>di</strong> Biochimica,<br />

Università <strong>di</strong> Padova<br />

Angiogenesi indotta dalla “heat shock protein” Glucose-regulated protein 94 (GRP94) con<br />

meccanismo simile a quello <strong>di</strong> una citochina.<br />

Rodolico Gabriella, Piegari E., Vitelli M.R., Damiano V., Rossi F., Berrino L.<br />

Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Sezione <strong>di</strong> Farmacologia “L. Donatelli”, Centro <strong>di</strong> Eccellenza<br />

delle Malattie Car<strong>di</strong>ovascolari, Seconda Università <strong>di</strong> Napoli<br />

Variazione dell’espressione genica in cuori isolati <strong>di</strong> ratto <strong>di</strong>abetico e non perfusi con una soluzione<br />

ad alta concentrazione <strong>di</strong> glucosio.<br />

Conti Valeria 1 , Corbi G. 2 , Boccuti S. 3 , Ferrara N. 2 , Carusio N. 3 , Rinal<strong>di</strong> B. 3 , Rossi F. 3 ,<br />

Filippelli A. 3<br />

1 Scuola <strong>di</strong> Specializzazione in Farmacologia, Seconda Università <strong>di</strong> Napoli; 2 Dipartimento <strong>di</strong> Scienze<br />

della Salute, Università del Molise e Fondazione S. Maugeri, Istituto Scientifico <strong>di</strong> Telese Terme;<br />

3 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale e Centro <strong>di</strong> Eccellenza delle Malattie Car<strong>di</strong>ovascolari,<br />

Seconda Università <strong>di</strong> Napoli<br />

L’esercizio fisico prolungato e moderato in ratti anziani potenzia l’attività della sirtuina 1.<br />

Amoruso Angela 1 , Bardelli C. 1 , Ribichini F. 2 , Ferrero V. 2 , Vassanelli C. 2 , Brunelleschi S. 1<br />

1 Dipartimento <strong>di</strong> Scienze Me<strong>di</strong>che, Università Piemonte Orientale, Novara; 2 Divisione <strong>di</strong> Car<strong>di</strong>ologia,<br />

Università <strong>di</strong> Verona<br />

Differenze <strong>di</strong> genere nell’espressione <strong>di</strong> PPAR-gamma in pazienti affetti da coronaropatie.<br />

pag_dx.indd 1 30/05/2007 1.20.32


Esposito Emanuela 1,3 , Mazzon E. 2,3 , Muià C. 2 , Meli R. 1 , Bramanti P. 3 , Caputi A.P. 2,3 ,<br />

Cuzzocrea S. 2,3<br />

1 Dipartmento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”; 2 Dipartimento <strong>di</strong><br />

Me<strong>di</strong>cina Sperimentale e Clinica e Farmacologia, Università <strong>di</strong> Messina; 3 IRCCS Centro Neurolesi<br />

"Bonino-Pulejo", Messina<br />

L’inibizione genetica e farmacologica del TNF- riduce il danno da ischemia e riperfusione splancnica.<br />

38<br />

Cre<strong>di</strong>ti ECM assegnati 2<br />

Simposio<br />

Nuove prospettive terapeutiche nel trattamento della<br />

depressione. L'approccio melatoninergico: dalla farmacologia<br />

all'evidenza clinica<br />

Moderatori: Biggio G (Cagliari) Lorettu L (Sassari)<br />

15.00/15.10 Carpiniello B (Cagliari)<br />

Introduzione<br />

SALA 3<br />

15.00-17.30<br />

15.10/15.40 Aguglia E (Trieste)<br />

Il trattamento della depressione oggi: realtà clinica nell'uso <strong>degli</strong> antidepressivi<br />

15.40/16.10 Racagni G (Milano)<br />

Un nuovo step nella ricerca farmacologica: l'approccio melatoninergico<br />

16.10/16.40 Monteleone P (Napoli)<br />

Depressione e ritmi circa<strong>di</strong>ani: razionale per l'impiego <strong>di</strong> un antidepressivo<br />

melatoninergico<br />

16.40/17.10 Altamura AC (Milano)<br />

Depressione Maggiore: efficacia clinica e tollerabilità <strong>di</strong> un nuovo antidepressivo<br />

melatoninergico<br />

17.10/17.30 Biggio G (Cagliari)<br />

Conclusione e Questionario ECM<br />

Simposio<br />

Infiammazioni e sindromi coronariche acute: stato dell'arte<br />

SALA 4<br />

15.00-17.30<br />

Moderatori: Rossi F (Napoli) Golino P (Napoli)<br />

15.00/15.30 Biasucci L (Roma)<br />

L'attivazione del sistema immunitario nella placca è conseguenza <strong>di</strong> un evento<br />

infiammatorio sistemico<br />

15.30/16.00 De Palma R (Napoli)<br />

L'attivazione del sistema immunitario nella placca è conseguenza <strong>di</strong> un evento<br />

infiammatorio locale<br />

16.00/16.30 Berrino L (Napoli)<br />

Differenti patterns <strong>di</strong> espressione genica nelle placche instabili<br />

16.30/17.00 Tremoli E (Milano)<br />

Markers <strong>di</strong> attivazione piastrinica nella placca aterosclerotica<br />

17.00/17.30 Cattaneo M (Milano)<br />

Clopidogrel e sindromi coronariche acute: cosa c'è oltre l'effetto antiaggregante?<br />

pag_sx.indd 1 30/05/2007 7.07.50


Tavola Rotonda<br />

Farmacologia <strong>di</strong> genere: dal laboratorio alla società<br />

SALA 5<br />

15.00-17.30<br />

Moderatori: Franconi F (Sassari) Caporale C (Roma) Schirru A (Cagliari)<br />

15.00/15.10 Franconi F (Sassari) Caporale C (Roma)<br />

Presentazione della tavola rotonda<br />

15.10/15.40 Bellantuono C (Verona)<br />

Antidepressivi e rischio <strong>di</strong> malformazioni maggiori<br />

15.40/15.50 Marilotti L (Cagliari)<br />

Il <strong>di</strong>ritto alla salute<br />

15.50/16.10 Vella S (Roma)<br />

La farmacologia <strong>di</strong> genere nella ricerca pubblica ed in clinica<br />

16.10/16.30 Mazzaglia G (Firenze)<br />

Potenzialità della ricerca epidemiologica sui flussi correnti nella specificità <strong>di</strong> genere<br />

16.30/16.45 Cricelli C (Firenze)<br />

La farmacologia <strong>di</strong> genere e la me<strong>di</strong>cina <strong>di</strong> base<br />

16.45/17.05 Ruffilli MP (Roma)<br />

La farmacologia <strong>di</strong> genere e la ricerca industriale<br />

17.05/17.25 Linguiti D (Roma)<br />

La politica delle pari opportunità e la salute delle donne<br />

17.25/17.30 Franconi F (Sassari)<br />

Conclusioni<br />

39<br />

Simposio<br />

<strong>Stu<strong>di</strong></strong> <strong>di</strong> sicurezza dei me<strong>di</strong>cinali biologici (anticorpi monoclonali)<br />

(<strong>SIF</strong> - SITOX)<br />

SALA 6<br />

15.00-17.30<br />

Moderatori: Cantelli Forti G (Bologna) Riccar<strong>di</strong> C (Perugia)<br />

15.00/15.30 Ascione A (Roma)<br />

Biotecnologie immunologiche e loro applicazione<br />

15.30/16.00 Dempster A (Cambridge, USA)<br />

Non clinical safety evaluation of biotechnologically derived pharmaceuticals<br />

16.00/16.30 Bernar<strong>di</strong> C (Milano)<br />

I primati non umani nella ricerca dei me<strong>di</strong>cinali biologici<br />

16.30/17.00 Meneguz A (Roma)<br />

Le prospettive regolatorie dopo il caso TGN 1412<br />

17.00/17.30 Rossi P (Roma)<br />

Il nostro fantastico sistema immunitario<br />

pag_dx.indd 1 30/05/2007 1.25.58


Simposio<br />

La formazione specialistica in Farmacologia<br />

SALA 7<br />

15.00-17.30<br />

40<br />

Moderatore: Chiesara E (Milano) Caputi AP (Messina)<br />

15.00/15.15 Chiesara E (Milano)<br />

Presentazione del problema<br />

15.15/15.30 Frigo G (Pavia)<br />

Stato dell'arte<br />

15.30/15.45 Patrono C (Roma)<br />

Sperimentazione Clinica-Farmacologica in Italia<br />

15.45/16.00 Furlanut M (U<strong>di</strong>ne)<br />

Esperienze regionali<br />

16.00/16.15 Ad<strong>di</strong>s A (Roma)<br />

La formazione a <strong>di</strong>stanza (FAD) promossa dall'AIFA<br />

16.15/16.30 Cricelli C (Firenze)<br />

Il punto <strong>di</strong> vista della SIMG<br />

16.30/16.45 Del Tacca M (Pisa)<br />

Sbocchi professionali<br />

16.45/17.00 Cella S (Milano)<br />

Interventi preor<strong>di</strong>nati: esperienze ospedaliere<br />

17.00/17.20 Discussione<br />

17.20/17.30 Caputi AP (Messina)<br />

Conclusioni<br />

Sessione ECM<br />

Simposio<br />

Farmacoutilizzazione e appropriatezza d'uso dei farmaci<br />

Moderatori: Giusti P (Padova) Corrao G (Milano)<br />

15.00/15.20 Lucioni C (Milano)<br />

Consumo <strong>di</strong> farmaci: dosaggi empirici verso appropriatezza terapeutica<br />

15.20/15.40 Haycox A (Liverpool)<br />

Utilizzo <strong>di</strong> data base nelle realtà europee<br />

SALA 8<br />

15.00-17.30<br />

15.40/16.00 Zambon A (Milano)<br />

Fattori pre<strong>di</strong>ttori <strong>di</strong> <strong>di</strong>scontinuità e <strong>di</strong> fallimento della terapia con bisfosfonati:<br />

risultati da uno stu<strong>di</strong>o <strong>di</strong> coorte basato su <strong>di</strong> un'ampia popolazione<br />

16.00/16.20 Mazzaglia G (Firenze)<br />

Analisi della relazione tra l'aderenza alla terapia con antiipertensivi e l'insorgenza <strong>di</strong><br />

eventi car<strong>di</strong>ovascolari non fatali in comunità<br />

16.20/16.40 Chiroli S (Milano)<br />

Valutazione dell'efficacia comparativa nell'Unione Europea: dati e metodologia<br />

16.40/17.00 Chinellato A (Treviso)<br />

Epidemiologia e trattamento del dolore da cancro: stiamo uccidendo la morfina?<br />

17.00/17.30 Discussione<br />

Realizzato con il contributo educazionale <strong>di</strong> AstraZeneca, Amgen, Abbott<br />

pag_sx.indd 1 04/06/2007 11.42.57


Simposio<br />

Nuovi aspetti patogenetici e terapeutici della<br />

neurodegenerazione<br />

(<strong>SIF</strong> - ITINAD)<br />

Moderatori: Canonico PL (Novara) Caltagirone CF (Roma)<br />

Sessione ECM<br />

17.30/17.55 Copani AG (Catania)<br />

Il ruolo del ciclo cellulare nella malattia <strong>di</strong> Alzheimer: implicazioni per la<br />

neuroprotezione<br />

17.55/18.20 Di Luca M (Milano)<br />

Meccanismi molecolari <strong>di</strong> malattie neurodegenerative<br />

18.20/18.45 Borroni B (Verona)<br />

Modelli periferici e terapia<br />

AUDITORIUM<br />

17.30-19.30<br />

18.45/19.10 Ghiglieri V (Roma)<br />

Modelli sperimentali <strong>di</strong> malattia <strong>di</strong> Parkinson: un approccio comportamentale ed<br />

elettrofisiologico<br />

19.10/19.30 Memo M (Brescia)<br />

Attività cellulari della proteina beta amiloide<br />

Realizzato con il contributo educazionale <strong>di</strong> Bracco<br />

41<br />

Sessione ECM<br />

Simposio<br />

La neurobiologia ed i trattamenti farmacologici del poliabuso<br />

Moderatori: Nava F (Padova) Tagliamonte A (Siena)<br />

17.30/17.50 Tagliamonte A (Siena)<br />

Introduzione al fenomeno del poliabuso<br />

17.50/18.10 Nava F (Padova)<br />

Le basi neurobiologiche della clinica del poliabuso<br />

18.10/18.30 Ciccocioppo R (Camerino)<br />

La ricerca traslazionale nella polydrug ad<strong>di</strong>ction: il ruolo del recettore della<br />

nocicettina<br />

18.30/18.50 Diana M (Iglesias)<br />

Il ruolo del poliabuso nel paziente con doppia <strong>di</strong>agnosi<br />

18.50/19.30 Discussione<br />

SALA 1<br />

17.30-19.30<br />

Realizzato con il contributo educazionale <strong>di</strong> Laboratori Farm. CT<br />

pag_dx.indd 1 30/05/2007 1.29.27


Sessione ECM<br />

Simposio<br />

Farmaci inibitori della pompa protonica e danno <strong>di</strong>gestivo indotto<br />

da FANS: aspetti farmacologici e clinici<br />

Moderatori: Del Tacca M (Pisa) Tonini M (Pavia)<br />

17.30/17.55 Tonini M (Pavia)<br />

Meccanismi d'azione dei farmaci inibitori della pompa protonica<br />

SALA 3<br />

17.30-19.30<br />

17.55/18.20 Blan<strong>di</strong>zzi C (Pisa)<br />

Inibitori <strong>di</strong> pompa protonica e secrezione gastrica: determinanti farmaco<strong>di</strong>namici,<br />

farmacocinetici e farmacogenetici<br />

18.20/18.45 De Ponti F (Bologna)<br />

Effetti dei FANS sui meccanismi <strong>di</strong> protezione e riparazione della mucosa <strong>di</strong>gestiva:<br />

basi molecolari<br />

18.45/19.10 Scarpignato C (Parma)<br />

COXIB e apparato <strong>di</strong>gerente: una promessa mantenuta?<br />

19.10/19.30 Pilotto A (S. Giovanni Rotondo)<br />

Ruolo <strong>degli</strong> inibitori <strong>di</strong> pompa protonica nel trattamento <strong>degli</strong> effetti avversi <strong>di</strong>gestivi<br />

dei FANS<br />

42<br />

Realizzato con il contributo educazionale <strong>di</strong> AstraZeneca, Malesci<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Farmacologia del dolore e infiammazione<br />

SALA 4<br />

17.30-19.30<br />

Moderatori: Calignano A (Napoli) Maione S (Napoli)<br />

Colucci Mariantonella 1 , Maione F. 1,2 , Federica M. 3 , Di Giannuario A. 1 , Pieretti S. 1<br />

1 Istituto Superiore <strong>di</strong> Sanità, Dipartimento del Farmaco, Roma; 2 Dipartimento <strong>di</strong> Farmacologia<br />

Sperimentale, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Napoli “Federico II”, Napoli; 3 Dipartimento <strong>di</strong> Fisiologia e<br />

Farmacologia “Vittorio Erspamer” Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Roma “La Sapienza”, Roma<br />

Il ruolo del recettore dei pepti<strong>di</strong> formilati nel controllo della trasmissione nocicettiva: un contributo<br />

dai topi transgenici mancanti <strong>di</strong> tale recettore.<br />

Calignano Antonio, La Rana G., Russo R., Sasso O., D’Agostino G.<br />

Dip. Farmacologia Sperimentale, Facoltà <strong>di</strong> Farmacia, Napoli<br />

Gli agonisti PPAR- inducono analgesia attraverso l’attivazione dei canali del potassio ad ampia e<br />

me<strong>di</strong>a conduttanza.<br />

Lattanzi Roberta, Franchi S. 1 , Sacerdote P. 1 , Melchiorri P., Negri L.<br />

Dipartimento Fisiologia Umana e Farmacologia, Roma “La Sapienza”; 1 Dipartimento <strong>di</strong> Farmacologia,<br />

Milano<br />

Le prostaglan<strong>di</strong>ne contribuiscono alla sensitizzazione nocicettiva indotta da Bv8.<br />

pag_sx.indd 1 30/05/2007 1.31.40


Siniscalco Dario, Giordano C., Luongo L., de Novellis V., Rossi F., Di Marzo V. 1 , Maione S.<br />

1 Istituto <strong>di</strong> Chimica Biomolecolare, CNR Pozzuoli (NA); Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Sez.<br />

Farmacologia, Seconda Università <strong>di</strong> Napoli<br />

Espressione dei geni dell’Apoptosi in un modello murino <strong>di</strong> dolore neuropatico: ruolo del sistema<br />

endocannabinoide.<br />

Ghelar<strong>di</strong>ni Carla, Vivoli E., Norcini M., Bartolini A., Martinelli M. 1 , Petrillo P. 1 , Farina C. 1<br />

Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Firenze, Firenze; 1 NiKem Research Srl, Milano<br />

Effetti anti-iperalgesici del derivato pirroli<strong>di</strong>nonico nik-13317 in modelli <strong>di</strong> dolore neuropatico.<br />

Moderatori: Filippelli A (Napoli) Bernar<strong>di</strong>ni R (Catania)<br />

Viaro Riccardo 1 , Marti M. 1 , Morari M. 1 , Franchi G. 2<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Ferrara;<br />

2 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che e Terapie Avanzate, Sezione <strong>di</strong> Fisiologia Umana, Università <strong>di</strong><br />

Ferrara<br />

I recettori per la nocicettina/orfanina FQ localizzati nella sostanza nera reticolata modulano l’attività<br />

motoria e l’eccitabilità della corteccia motoria primaria nel ratto.<br />

Savani Clau<strong>di</strong>a 1,2 , De Filippis D. 3 , Scuderi C. 1,4 , Carnuccio R. 3 , De Stefano D. 3 , Iuvone T. 3 ,<br />

Esposito G. 1 , Steardo L. 1<br />

1 Dipartimento <strong>di</strong> Fisiologia umana e Farmacologia “Vittorio Erspamer”, Università “La Sapienza”,<br />

Roma; 2 Dipartimento <strong>di</strong> Fisiologia umana e Farmacologia, Università <strong>di</strong> Bari; 3 Dipartimento <strong>di</strong><br />

Farmacologia Sperimentale, Università <strong>di</strong> Napoli Federico II; 4 Dipartimento <strong>di</strong> Scienze<br />

Farmacologiche, Università <strong>di</strong> Palermo<br />

Proprietà antiinfiammatorie della PEA in cellule C6 stimolate con peptide beta amiloide.<br />

43<br />

Franchi Silvia, Panerai A., Negri L. 1 , Melchiorri P. 1 , Sacerdote P.<br />

Dipartimento <strong>di</strong> Farmacologia Chemioterapia e Tossicologia Me<strong>di</strong>ca, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano;<br />

1 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, Università La Sapienza, Roma<br />

Il sistema delle prokineticine/Bv8 come nuovo modulatore delle risposte immuni: rilevanza nelle<br />

malattie infiammatorie.<br />

Amantea Diana 1 , Gliozzi M. 2 , Corasaniti M.T. 2 , Bagetta G. 1<br />

1 Dipartimento Farmacobiologico, Università della Calabria, Rende (CS); 2 Dipartimento <strong>di</strong> Scienze<br />

Farmacobiolgiche, Università “Magna Graecia”, Catanzaro<br />

Le metalloproteinasi della matrice (MMPs) sono coinvolte nell’aumento precoce <strong>di</strong> interleuchina (IL-<br />

1) indotto da ischemia cerebrale focale transitoria nel ratto.<br />

Gianella Anita 1 , Nobili E. 1 , Gelosa P. 1 , Mussoni L. 1 , Bellosta S. 1 , Canadesi M. 1 , Abbate M. 2 ,<br />

Zoja C. 2 , Tremoli E. 1,3 , Sironi L. 1<br />

1 Dipartimento Scienze Farmacologiche, Università <strong>di</strong> Milano; 2 Centro Car<strong>di</strong>ologico Monzino IRCCS,<br />

Milano; 3 Ist. Mario Negri, Bergamo<br />

La rosuvastatina previene il danno renale spontaneo nei ratti SHRSP modulando il sistema<br />

plasminogeno/plasmina e l'espressione delle metalloproteasi.<br />

pag_dx.indd 1 30/05/2007 1.35.22


Simposio<br />

Targets cellulari e molecolari per lo sviluppo <strong>di</strong> nuove terapie in<br />

corso <strong>di</strong> neuroAIDS<br />

SALA 5<br />

17.30-19.30<br />

44<br />

Moderatori: Bagetta G (Cosenza) Pittaluga A (Genova)<br />

17.30/17.50 Pittaluga A (Genova)<br />

Interazione tra proteine del virus HIV-1 e recettori per il glutammato: loro ruolo in<br />

corso <strong>di</strong> neuroAIDS<br />

17.50/18.10 Viviani B (Milano)<br />

IL-1 beta e recettore NMDA: un pericoloso legame in corso <strong>di</strong> neuroAIDS<br />

18.10/18.30 Russo R (Cosenza)<br />

Definizione <strong>di</strong> un ruolo per la metalloproteasi della matrice (MMPs) nell'apoptosi<br />

neuronale indotta dalla gp120 del virus HIV-1 nel ratto<br />

Moderatori: Mollace V (Catanzaro) Marinovich M (Milano)<br />

18.30/18.50 Bezzi P (Losanna)<br />

Esocitosi Ca 2+ -regolata <strong>di</strong> glutammato da astrociti: un duplice ruolo nella<br />

comunicazione normale e patologica tra neuroni e glia<br />

18.50/19.10 Sgura A (Roma)<br />

Ruolo dello stress ossidativo nell'apoptosi me<strong>di</strong>ata dal virus HIV-1 e sulla lunghezza<br />

dei telomeri in una linea cellulare umana <strong>di</strong> astrocitoma<br />

19.10/19.30 Muscoli C (Cosenza)<br />

Modulazione farmacologica dello stress ossidativo nei <strong>di</strong>sor<strong>di</strong>ni neurodegenerativi da<br />

HIV<br />

Simposio<br />

Meccanismi farmacologici che regolano la proliferazione e il<br />

<strong>di</strong>fferenziamento delle cellule staminali<br />

SALA 6<br />

17.30-19.30<br />

Moderatori: Melchiorri D (Roma) Gorio A (Milano)<br />

17.30/17.50 Finocchiaro G (Milano)<br />

Cellule staminali da cancro<br />

17.50/18.10 Gorio A (Milano)<br />

Cellule staminali e lesioni midollari<br />

18.10/18.30 Reitano E (Milano)<br />

Terapia <strong>di</strong> sostituzione cellulare con cellule staminali<br />

18.30/18.50 Sartiani L (Firenze)<br />

Differenziamento car<strong>di</strong>omiocitario delle cellule staminali embrionali: proprietà<br />

funzionali e fattori <strong>di</strong> modulazione<br />

18.50/19.10 Melchiorri D (Roma)<br />

Ruolo dei recettori metabotropici del glutammato nel <strong>di</strong>fferenziamento delle cellule<br />

staminali<br />

19.10/19.30 Discussione<br />

pag_sx.indd 1 30/05/2007 1.39.57


Simposio<br />

Canali ionici come bersagli terapeutici per malattie genetiche e<br />

non-genetiche<br />

SALA 7<br />

17.30-19.30<br />

Moderatori: Conte Camerino D (Bari) Fontaine B (Parigi)<br />

17.30/17.50 Fontaine B (Parigi)<br />

Malattie dei canali del nervo e del muscolo<br />

17.50/18.10 Tricarico D (Bari)<br />

Coinvolgimento dei canali K + nelle patologie muscolari genetiche e non:<br />

dall'espressione genica alla terapia farmacologica<br />

18.10/18.30 Taglialatela M (Campobasso)<br />

Fisiopatologia e farmacologia molecolari dei canali KCNQ neuronali<br />

18.30/18.50 Sanna E (Cagliari)<br />

Recettori GABA A extrasinaptici: ruolo fisiologico, plasticità e nuove prospettive<br />

farmacologiche<br />

18.50/19.10 Evoli A (Roma)<br />

Canalopatie paraneoplastiche<br />

19.10/19.30 Cerbai E (Firenze)<br />

La corrente I f in cellule car<strong>di</strong>ache non-pacemaker: ruolo e implicazioni farmacologiche<br />

Sessione ECM<br />

Simposio<br />

La malattia <strong>di</strong> Parkinson: dalla biologia molecolare alla terapia<br />

(<strong>SIF</strong> - LIMPE)<br />

Moderatori: Corsini GU (Pisa) Ruggeri S (Roma)<br />

17.30/18.00 Morelli M (Cagliari)<br />

Fisiopatologia dei gangli della base<br />

18.00/18.30 Fornai F (Pisa)<br />

Nuovi aspetti patogenetici<br />

18.30/19.00 Maggio R (L’Aquila)<br />

Basi farmacologiche della terapia<br />

19.00/19.30 Bonucelli U (Pisa)<br />

Nuove terapie<br />

SALA 8<br />

17.30-19.30<br />

45<br />

pag_dx.indd 1 30/05/2007 1.41.07


Sessione ECM<br />

Simposio<br />

La cascata della via WNT come target delle patologie<br />

neurodegenerative<br />

Moderatori: Gaviraghi G (Siena) Pepeu G (Firenze)<br />

AUDITORIUM<br />

08.30-11.00<br />

08.30/08.55 Nicoletti F (Roma)<br />

L'induzione dell'antagonista della via <strong>di</strong> WNT, Dickkopf-1, come marker <strong>di</strong> morte<br />

neuronale eccitotossica<br />

08.55/09.20 Caricasole A (Siena)<br />

La via <strong>di</strong> WNT e la malattia <strong>di</strong> Alzheimer<br />

09.20/09.45 Casamenti F (Firenze)<br />

<strong>Stu<strong>di</strong></strong>o della cascata della via WNT in modelli animali <strong>di</strong> malattia <strong>di</strong> Alzheimer<br />

09.45/10.10 Hoozemanns J (Amsterdam)<br />

<strong>Stu<strong>di</strong></strong>o del pathway WNT in encefali postmortem in pazienti con malattia <strong>di</strong> Alzheimer<br />

10.10/11.00 Discussione<br />

46<br />

Tavola Rotonda<br />

La prima del farmaco sull'uomo<br />

Moderatori: Vella S (Roma) Velo GP (Verona)<br />

08.30/09.10 Breckenridge A (London)<br />

The day the sky fell in. TGN 1412 and what happened next<br />

09.10/09.30 Popoli P (Roma)<br />

"Piccoli" stu<strong>di</strong> crescono: la sperimentazione clinica <strong>di</strong> fase I in Italia<br />

09.30/09.55 Tomino C (Roma)<br />

La ricerca clinica: crocevia tra investimenti, costi ed opportunità <strong>di</strong> sviluppo<br />

09.55/10.20 Bonino F (Milano)<br />

Le strane coppie, i stu<strong>di</strong> investigator initiated and industry co-sponsored<br />

10.20/10.45 Ruffilli MP (Roma)<br />

La ricerca nell'uomo: un grande viaggio inizia dal primo passo<br />

10.45/11.00 Discussione<br />

SALA1<br />

08.30-11.00<br />

pag_sx.indd 1 30/05/2007 2.00.31


Sessione ECM<br />

Simposio<br />

Farmacologia dei recettori TRPV1 (vanilloi<strong>di</strong>) nel sistema nervoso<br />

centrale e periferico<br />

Moderatori: Di Marzo V (Napoli) Maione S (Napoli)<br />

SALA 2<br />

08.30-11.00<br />

08.30/08.50 Appen<strong>di</strong>no G (Novara)<br />

I composti naturali come prototipi per la scoperta <strong>di</strong> nuovi attivatori/inibitori <strong>di</strong> TRPV1<br />

e canali ionici correlati<br />

08.50/09.10 Geppetti P (Firenze)<br />

Sviluppo <strong>di</strong> potenti e selettivi ligan<strong>di</strong> del canale TRPV1 e loro potenzialità terapeutiche<br />

09.10/09.30 Di Marzo V (Napoli)<br />

Distribuzione, regolazione e ruolo fisiopatologico dei recettori TRPV1 nel cervello<br />

09.30/09.50 De Novellis V (Napoli)<br />

Gli endovanilloi<strong>di</strong> controllano l'attività del sistema <strong>di</strong>scendente inibitorio del dolore<br />

09.50/10.10 Wotjak CT (Monaco)<br />

Role of TRPV1 receptor in fear and anxiety<br />

10.10/11.00 Discussione<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Farmacologia car<strong>di</strong>ovascolare<br />

Moderatori: Cerbai E (Firenze) Desole MS (Sassari)<br />

SALA 3<br />

08.30-11.30<br />

Pierno Sabata 1 , Camerino G.M. 1 , Cippone V. 1 , Liantonio A. 1 , De Luca A. 1 , Kunic J. 2 , George<br />

A.L. Jr. 2 , Conte Camerino D. 1<br />

1 Sezione <strong>di</strong> Farmacologia, Dipartimento Farmaco-biologico, Università <strong>di</strong> Bari; 2 Dept. of Me<strong>di</strong>cine,<br />

Vanderbilt University, Nashville, TN, USA<br />

Meccanismi molecolari responsabili della mo<strong>di</strong>ficazione della conduttanza <strong>di</strong> membrana sostenuta dal<br />

canale al cloro clc-1 nel muscolo scheletrico <strong>di</strong> ratti trattati cronicamente con statine e fibrati.<br />

47<br />

Rinal<strong>di</strong> Barbara, Donniacuo M. 1 , Cappetta D. 1 , Capuano A. 1 , Romagnoli P. 2 , De Angelis A. 1 ,<br />

De Stefano D. 3 , Rossi F. 1 , Filippelli A. 1<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale e Centro <strong>di</strong> Eccellenza delle Malattie Car<strong>di</strong>ovascolari, Seconda<br />

Università <strong>di</strong> Napoli, Italia; 2 Dipartimento <strong>di</strong> Anatomia, Istologia e Me<strong>di</strong>cina Legale sez. E. Allara<br />

Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Firenze, Italia; 3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong><br />

Napoli Federico II Italia<br />

Il rosigliatazone riduce il processo infiammatorio indotto da un danno vascolare nel ratto.<br />

Di Francesco Luigia 1 , Piccoli A. 2 , Capone M. 1 , Evangelista V. 2 , Totani L. 2 , Patrignani P. 1<br />

1 Università G d’Annunzio, Chieti, Italy; 2 Mario Negri Sud, Santa Maria Imbaro Chieti<br />

Contributo delle isoforme della ciclo-ossogenasi alla produzione <strong>di</strong> prostaciclina e prostaglan<strong>di</strong>na E2<br />

da parte delle cellule endoteliali in risposta allo shear stress laminare.<br />

pag_dx.indd 1 30/05/2007 1.53.12


Benetti Elisa 1 , Collino M. 1 , Thiemermann C. 3 , Mastrocola R. 2 , Gallicchio M. 1 , Dianzani C. 1 ,<br />

Danni O. 2 , Aragno M. 2 , Fantozzi R. 1<br />

1 Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale. Università <strong>di</strong> <strong>Torino</strong>; 2 Dipartimento <strong>di</strong><br />

Me<strong>di</strong>cina Sperimentale e Oncologia, Università <strong>di</strong> <strong>Torino</strong>; 3 Centre for Exp Med, Nephrology & Critical<br />

Care, William Harvey Research Institute, London, UK<br />

L’inibitore selettivo della Glicogeno Sintasi Kinasi-3b, TDZD-8, riduce il danno indotto da una parziale<br />

ischemia-riperfusione cerebrale nell’ippocampo <strong>di</strong> ratto.<br />

Rossoni Giuseppe 1 , Sparatore A. 2 , Moore P.K. 3 , Manfre<strong>di</strong> B. 1 , Tazzari V. 4 , Del Soldato P. 4 ,<br />

Berti F. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia, Chemioterapia e Tossicologia Me<strong>di</strong>ca, Università <strong>di</strong> Milano, Italia;<br />

2 Istituto <strong>di</strong> Chimica Farmaceutica e Tossicologica "Pietro Pratesi", Università <strong>di</strong> Milano, Italia;<br />

3 Dipartimento <strong>di</strong> Farmacologia, Università Nazionale <strong>di</strong> Singapore, Singapore; 4 CTG Pharma, Milano,<br />

Italia<br />

Effetto car<strong>di</strong>oprotettivo del solfo-<strong>di</strong>clofenac nel cuore ischemico-reperfuso <strong>di</strong> coniglio.<br />

48<br />

Deambrosis Paola 1 , Saramin C. 1 , Terrazzani G. 1 , Bader G. 2 , Scaldaferri E. 3 , Chinellato A. 1 ,<br />

Giusti P. 4<br />

1 Servizio farmaceutico territoriale, Ulss9 Treviso; 2 Outcome research, Pfizer Roma; 3 I° Centro<br />

Anti<strong>di</strong>abetico, Me<strong>di</strong>cina I, Ulss9 Treviso; 4 Dipartimento <strong>di</strong> Farmacologia e Anestesiologia, Università <strong>di</strong><br />

Padova<br />

Effetti della terapia con statine sui livelli <strong>di</strong> colesterolo e sui ricoveri ospedalieri per patologie<br />

car<strong>di</strong>ovascolari, nell’ULSS <strong>di</strong> Treviso.<br />

Marasciulo Flora L, Potenza M.A., Tarquinio M., Quon M.J. 1 , Montagnani M.<br />

Dipartimento <strong>di</strong> Farmacologia e Fisiologia Umana, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Bari ; 1 Diabetes Unit,<br />

National Center for Complementary and Alternative Me<strong>di</strong>cine, National Institutes of Health, Bethesda,<br />

MD 20892, USA<br />

Meccanismi molecolari coinvolti negli effetti acuti e cronici dell’epigallocatechina gallato, un polifenolo<br />

del tè verde, sulla regolazione della funzione vascolare in ratti spontaneamente ipertesi (SHR).<br />

Chiesa Giulia, Parolini C., Marchesi M., Diani E., RIgamonti E., Cornelli L., Sirtori C.R.<br />

Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano<br />

Ridotta progressione <strong>di</strong> aterosclerosi in conigli alimentati con proteine <strong>di</strong> lupino.<br />

Vinci Maria Cristina, Bellik L., Parenti A., Ledda F.<br />

Laboratorio <strong>di</strong> Farmacologia Vascolare, Dipartimento <strong>di</strong> Farmacologia Clinica e Preclinica, Università <strong>di</strong><br />

Firenze<br />

Un biopolimero costituito da acido ialuronico (HYAFF-11) come supporto per la crescita <strong>di</strong> cellule<br />

progenitrici endoteliali umane.<br />

pag_sx.indd 1 30/05/2007 2.01.26


Sessione ECM<br />

Simposio<br />

Nocicettina/orfanina FQ: dagli stu<strong>di</strong> <strong>di</strong> base alla clinica<br />

Moderatori: Massi M (Camerino) Regoli D (Ferrara)<br />

08.30/08.50 Calò G (Ferrara)<br />

Il sistema nocicettina/orfanina FQ-recettore NOP e nuovi ligan<strong>di</strong> selettivi<br />

SALA 4<br />

08.30-11.00<br />

08.50/09.10 Ciccocioppo R (Camerino)<br />

Il sistema nocicettina/orfanina FQ come potenziale target per lo sviluppo <strong>di</strong> farmaci<br />

innovativi per la terapia dell'alcolismo<br />

09.10/09.30 Marti M (Ferrara)<br />

Il recettore della nocicettina/orfanina FQ come nuovo target per lo sviluppo <strong>di</strong> farmaci<br />

antiparkinsoniani<br />

09.30/09.50 Improta G (Roma)<br />

Ruolo del sistema nocicettina/orfanina FQ-recettore NOP nel controllo <strong>di</strong> attività<br />

secretorie e motorie gastrointestinali in con<strong>di</strong>zioni fisiologiche e patologiche<br />

09.50/10.10 D'Agostino B (Napoli)<br />

Ruolo della nocicettina e del suo recettore in un modello animale <strong>di</strong> infiammazione<br />

delle vie aeree<br />

10.10/10.30 Lazzeri M (Firenze)<br />

N-OFQ e recettore NOP: una nuova strategia nel trattamento dei <strong>di</strong>sturbi funzionali<br />

del basso tratto urinario<br />

10.30/11.00 Discussione<br />

49<br />

Sessione ECM<br />

Simposio<br />

Sistema nervoso - sistema immunitario tra interazione e<br />

integrazione: tempo per la neuro-immuno-farmacologia?<br />

(<strong>SIF</strong> - ISNIM)<br />

Moderatori: Cosentino M (Varese) Maestroni GJM (Locarno)<br />

SALA 5<br />

08.30-11.00<br />

08.30/08.50 Maestroni GJM (Locarno)<br />

Regolazione adrenergica <strong>di</strong>fferenziale della risposta immunitaria ai Pathogen<br />

Associated Molecular Patterns - Implicazioni nelle malattie infiammatorie e nei vaccini<br />

a base <strong>di</strong> cellule dendritiche<br />

08.50/09.10 Sacerdote P (Milano)<br />

La presenza <strong>di</strong> dolore modula la funzione immune e l’attivazione del sistema<br />

immunitario è coinvolta nella trasmissione nocicettiva<br />

09.10/09.30 Capellino SH (Regensburg)<br />

Meccanismi simpatoadrenergici nell'infiammazione sinoviale<br />

09.30/09.50 Marino F (Varese)<br />

Modulazione dopaminergica della funzionalità dei linfociti T regolatori: nuovi 'target'<br />

per la terapia farmacologica della sclerosi multipla?<br />

pag_dx.indd 1 30/05/2007 1.55.33


Comunicazioni<br />

Moderatori: Marino F (Varese) Lecchini S (Varese)<br />

D’Agostino Giuseppe 1 , La Rana G. 1 , Russo R. 1 , Sasso O. 1 , Iacono A. 1 , Esposito E. 1 , Cuzzocrea<br />

S. 2 , Meli R. 1 , Calignano A. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II <strong>di</strong> Napoli; 2 Dipartimento <strong>di</strong><br />

Me<strong>di</strong>cina e Farmacologia Clinica e Sperimentale, Università <strong>di</strong> Messina<br />

Il recettore PPAR-alfa centrale modula lo sviluppo dell’edema da carragenina nel topo.<br />

Lattanzi Roberta 1 , Giannini E. 1 , Campese A. 2 , Negri L. 1 , Melchiorri P. 1<br />

1 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, Università <strong>di</strong> Roma La Sapienza; 2 Dipartimento <strong>di</strong><br />

Me<strong>di</strong>cina Sperimentale e Patologia, Università <strong>di</strong> Roma La Sapienza<br />

Le prochineticine contribuiscono al dolore infiammatorio.<br />

Conti Silvia, Bertorelli R., Forlani A., Fredduzzi S., Nicolussi E., Reggiani A.<br />

Schering Plough Research Institute, Milano<br />

Ruolo del GW842166X, un agonista del recettore cannabico CB2, in <strong>di</strong>versi modelli <strong>di</strong> dolore<br />

neuropatico e infiammatorio nel ratto.<br />

50<br />

Cosentino Marco 1 , Zaffaroni M. 2 , Carcano E. 1 , Saporiti F. 1 , Ferrari M. 1 , Rasini E. 1 , Bombelli<br />

R. 1 , Perusin M. 1 , Grezzi A. 2 , Comi G. 2,3 , Marino F. 1 , Lecchini S. 1<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica, Sezione <strong>di</strong> Farmacologia Sperimentale e Clinica, Università<br />

dell’Insubria, Varese; 2 Centro per lo <strong>Stu<strong>di</strong></strong>o della Sclerosi Multipla, Ospedale <strong>di</strong> Gallarate, Varese;<br />

3 Istituto Scientifico S Raffaele Milano<br />

L’interferone-beta inibisce in vitro la funzionalità dei linfociti regolatori CD4+CD25+: ruolo <strong>di</strong><br />

meccanismi dopaminergici autocrini/paracrini.<br />

Simposio<br />

I nuovi farmaci target-specifici in oncologia<br />

SALA 6<br />

08.30-11.00<br />

Moderatori: Mantovani G (Cagliari) Mazzei T (Firenze)<br />

08.30/09.00 Fontanini G (Pisa)<br />

Patologia molecolare dei recettori dei fattori <strong>di</strong> crescita e delle chinasi nelle neoplasie<br />

solide<br />

09.00/09.30 Mini E (Firenze)<br />

Inibitori <strong>di</strong> EGFR e VEGF nella terapia dei tumori del tratto gastrointestinale<br />

09.30/10.00 Massidda B (Cagliari)<br />

Terapia target-specifica nel carcinoma polmonare non a piccole cellule<br />

10.00/10.30 Danesi R (Pisa)<br />

Integrazione <strong>di</strong> farmaci ad azione target-specifica con chemioterapia convenzionale<br />

10.30/11.00 Gebbia N (Palermo)<br />

Farmaci a bersaglio molecolare e pre<strong>di</strong>ttività della risposta<br />

pag_sx.indd 1 30/05/2007 2.10.01


Simposio<br />

Meccanismi d'azione <strong>degli</strong> antidepressivi: nuove acquisizioni<br />

SALA 7<br />

08.30-11.00<br />

Moderatore: Di Chiara G (Cagliari)<br />

08.30/09.00 Borsini F (Roma)<br />

Sviluppo delle teorie sul meccanismo d’azione <strong>degli</strong> antidepressivi<br />

09.00/09.30 Invernizzi R (Milano)<br />

Ruolo della triptofano idrosilasi-2 nella risposta agli SSRI: stu<strong>di</strong> comportamentali e <strong>di</strong><br />

micro<strong>di</strong>alisi nel topo<br />

09.30/10.00 Di Chiara G (Cagliari)<br />

Trattamento cronico con desipramina ed escitalopram su micro<strong>di</strong>alisi e ruolo dei<br />

recettori alfa2 e 5HT1A<br />

10.00/10.30 Demontis G (Siena)<br />

Mo<strong>di</strong>ficazioni dell’attività dell’asse ipotalamo-ipofisi-surrene in un modello<br />

sperimentale <strong>di</strong> depressione ed effetti dell’imipramina<br />

10.30/11.00 Spampinato U (Bordeaux)<br />

Interazione recettori 5HT2C e DA in corteccia<br />

Simposio<br />

Farmaci-farmacisti-farmacie<br />

Moderatori: Fioretti MC (Perugia) Fantozzi R (<strong>Torino</strong>)<br />

08.30/08.55 Diana P (Iglesias)<br />

La professione del farmacista<br />

Sessione ECM<br />

08.55/09.20 Fioretti MC (Perugia)<br />

SOT (OTC e SP): farmaci sicuri? Un'opportunità da non perdere in termini <strong>di</strong><br />

professionalità<br />

09.20/09.45 Massi M (Camerino)<br />

La formazione post-laurea del farmacista<br />

09.45/10.10 Fantozzi R (<strong>Torino</strong>)<br />

Il farmacista e le emergenze terapeutiche<br />

10.10/10.30 Filippi U (Milano)<br />

Il farmacista e la farmacia vista dall'industria<br />

10.30/11.00 Discussione<br />

SALA 8<br />

08.30-11.00<br />

51<br />

pag_dx.indd 1 30/05/2007 2.05.10


Sessione Plenaria<br />

La ricerca clinica in Italia: attualità e prospettive<br />

AUDITORIUM<br />

11.00-13.00<br />

Moderatori: Rossi F (Napoli) Scatigna M (Firenze)<br />

11.00/11.20 Tomino C (Roma)<br />

Attuale normativa e previsti cambiamenti nell'assetto regolatorio della<br />

sperimentazione clinica<br />

11.20/11.40 Scatigna M (Firenze)<br />

Ruolo dell'Italia nello sviluppo clinico farmaceutico<br />

11.40/12.00 Rossi F (Napoli)<br />

Il ruolo dell'Università nella ricerca clinica nazionale<br />

12.00/12.20 Vella S (Roma)<br />

La ricerca farmacologica nel VII programma quadro dell’Unione Europea<br />

12.20/12.40 Cricelli C (Firenze)<br />

La ricerca clinica in me<strong>di</strong>cina generale<br />

12.40/13.00 Discussione<br />

Realizzato con il contributo educazionale <strong>di</strong> Eli Lilly<br />

52<br />

pag_sx.indd 1 30/05/2007 2.07.46


FARMACOLOGIA DEL SISTEMA CARDIOVASCOLARE<br />

Pranzo riservato ai partecipanti<br />

SALA 3<br />

12.30-17.30<br />

12.30-13.00<br />

Simposio<br />

Appropriatezza nella terapia farmacologica car<strong>di</strong>ovascolare<br />

Incontro con l'Esperto<br />

Inibizione della corrente pacemaker IF: dall'elettrofisiologia alla<br />

pratica clinica<br />

13.00-14.30<br />

14.30-15.30<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Farmacologia car<strong>di</strong>ovascolare 15.30-17.30<br />

Simposio<br />

Appropriatezza nella terapia farmacologica car<strong>di</strong>ovascolare<br />

Moderatori: Biggio G (Cagliari) Lai C (Cagliari) Mugelli A (Firenze)<br />

13.00/13.30 Gaspardone A (Roma)<br />

Meccanismi <strong>di</strong> protezione vascolare <strong>degli</strong> inibitori dell'HMGCO-A reduttasi<br />

13.30/14.00 Caputi AP (Messina)<br />

Concetti <strong>di</strong> compliance, aderenza e continuità terapeutica nella patologia<br />

car<strong>di</strong>ovascolare: il punto <strong>di</strong> vista del farmacologo<br />

14.00/14.30 Colivicchi F (Roma)<br />

L'appropriatezza terapeutica nell'ambito delle statine: il punto <strong>di</strong> vista del clinico<br />

53<br />

Realizzato con il contributo educazionale <strong>di</strong> Pfizer<br />

Incontro con l'Esperto<br />

Sessione ECM<br />

Inibizione della corrente pacemaker IF: dall'elettrofisiologia alla pratica clinica<br />

Moderatori: Lai C (Cagliari) Mugelli A (Firenze)<br />

14.30/14.50 Mugelli A (Firenze)<br />

Inibizione della corrente pacemaker IF: il punto <strong>di</strong> vista del farmacologo<br />

14.50/15.10 Lai C (Cagliari)<br />

Inibizione della corrente pacemaker IF: il punto <strong>di</strong> vista del car<strong>di</strong>ologo<br />

15.10/15.30 Mugelli A (Firenze) Lai C (Cagliari)<br />

Discussione con gli esperti<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Farmacologia car<strong>di</strong>ovascolare<br />

Moderatori: Berrino L (Napoli) Tremoli E (Milano)<br />

Giuliani Daniela 2 , Colombo G. 1 , Sor<strong>di</strong> A. 1 , Lonati C. 1 , Mioni C. 2 , Leonar<strong>di</strong> P. 1 , Carlin A. 1 ,<br />

Bertolini A. 3 , Grieco P. 4 , Bazzani C. 2 , Catania A. 1 , Guarini S. 2<br />

1 Centro <strong>di</strong> Ricerca Preclinica, Fondazione IRCC, Ospedale Maggiore Policlinico, Mangiagalli e Regina<br />

Elena, Milano; 2 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena e<br />

Reggio Emilia; 3 Divisione Clinica Farmacologica, Università <strong>di</strong> Modena e Reggio Emilia; 4 Dipartimento<br />

<strong>di</strong> Chimica Farmaceutica e Tossicologica, Università Federico II <strong>di</strong> Napoli<br />

Basi molecolari dell’effetto protettivo conseguente a stimolazione del recettore melanocortinico MC4<br />

nello shock emorragico.<br />

pag_dx.indd 1 30/05/2007 2.11.58


Bitto Alessandra 1 , Minutoli L. 1 , Altavilla D. 1 , Polito F. 1 , Fiumara T. 1 , Di Stefano V. 1 , Giuliani<br />

D. 2 , Guarini S. 2 , Caputi A.P. 1 , Squadrito F. 1<br />

1 Dipartimento Clinico Sperimentale <strong>di</strong> Me<strong>di</strong>cina e Farmacologia, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong><br />

Messina; 2 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena e<br />

Reggio Emilia<br />

La terapia con simvastatina stimola la produzione <strong>di</strong> VEGF e migliora la cicatrizzazione delle ferite nel<br />

<strong>di</strong>abete sperimentale.<br />

Calabresi Laura 2 , Eberini I. 1 , Gianazza E. 1 , Gomaraschi M. 2 , Mombelli G. 2 , Breghi L. 3 ,<br />

Klugmann S 4 , Brusoni B 4 , Franceschini G 2 , Sirtori CR 2<br />

1 Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano, 2 Centro Grossi Paoletti, Dipartimento<br />

<strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano; 3 Divisione <strong>di</strong> Car<strong>di</strong>ologia, Ospedale <strong>di</strong> Circolo <strong>di</strong><br />

Voghera; 4 Divisione <strong>di</strong> Car<strong>di</strong>ologia, Ospedale <strong>di</strong> Niguarda, Milano; 5 Divisione <strong>di</strong> Car<strong>di</strong>ologia, Ospedale<br />

Fatebenefratelli, Milano<br />

Degradazione dell’apolipoproteina A-I da parte <strong>di</strong> farmaci trombolitici in pazienti infartuati.<br />

Camera Marina 1,2 , Brambilla M. 1 , Colnago D. 2 , De Metrio M. 2 , Marenzi G.C. 2 , Gertow K. 2 ,<br />

Tremoli E. 1,2<br />

1 Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano, 2 Centro Car<strong>di</strong>ologico Monzino IRCCS,<br />

Milano<br />

Caratterizzazione dell’espressione <strong>di</strong> Tissue Factor in piastrine, leucociti ed aggregati leucocitipiastrine<br />

<strong>di</strong> pazienti con malattia coronarica.<br />

54<br />

Tacconelli Stefania 1 , Di Febbo C. 1 , Douville K. 2 , Guglielmi M.D. 1 , Capone M.L. 1 , Porreca E. 1 ,<br />

Hwa J. 2 , Patrignani P. 1<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina e invecchiamento G d’Annunzio, Università e Fondazione G d’Annunzio,<br />

Chieti; 2 Dartmouth Me<strong>di</strong>cal Sch, Hanover, NH<br />

Polimorfismi del recettore umano della prostaciclina e eterogenesi.<br />

Parenti Astrid, Vinci M.C., Bellik L., Filippi S., Ledda F.<br />

Laboratorio <strong>di</strong> Farmacologia Vascolare, Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong><br />

Firenze<br />

La stimolazione dei recettori alfa-1D adrenergici induce effetti trofici sulle cellule endoteliali: ruolo<br />

dell’ipossia.<br />

Barbieri Silvia S 1,2 , Tremoli E. 2 , Weksler B.B. 1<br />

1 Division of Hematology-Me<strong>di</strong>cal Oncology, Weill Me<strong>di</strong>cal College of Cornell University, New York, NY,<br />

USA; 2 Dipartimento <strong>di</strong> Scienze Farmacologiche Università <strong>di</strong> Milano<br />

Il fumo <strong>di</strong> sigaretta coopera con IL-1 nell'alterare il trafficking <strong>di</strong> -catenina nell'endotelio vascolare<br />

con conseguente aumento della permeabilità e dell'espressione <strong>di</strong> cicloossigenase-2 in vivo e in vitro.<br />

Bucci Mariarosaria 1 , Roviezzo F. 1 , Brancaleone V. 1 , Di Lorenzo A. 1 , Rizzo G. 2 , Vellecco<br />

V. 1 , Fiorucci S. 1 , Cirino G. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II <strong>di</strong> Napoli; 2 Dipartimento <strong>di</strong><br />

Me<strong>di</strong>cina Clinica e Sperimentale, Laboratorio <strong>di</strong> Biologia Molecolare, Università <strong>di</strong> Perugia<br />

La vaso<strong>di</strong>latazione da testosterone è me<strong>di</strong>ata dal rilascio <strong>di</strong> H2S nell’aorta <strong>di</strong> ratto<br />

pag_sx.indd 1 30/05/2007 2.13.28


Sessione Poster<br />

13.00-15.00<br />

Colazione <strong>di</strong> lavoro<br />

13.00-14.00<br />

Sessione ECM<br />

Simposio<br />

Glucocorticoi<strong>di</strong>, meccanismi molecolari ed efficacia<br />

antinfiammatoria ed immunosoppressiva<br />

Moderatori: Fioretti MC (Perugia) Riccar<strong>di</strong> C (Perugia)<br />

15.00/15.25 Riccar<strong>di</strong> C (Perugia)<br />

Glucocorticoi<strong>di</strong> nel controllo della crescita cellulare: ruolo <strong>di</strong> GILZ<br />

AUDITORIUM<br />

15.00-17.30<br />

15.25/15.50 Parente L (Salerno)<br />

Inibizione da parte del desametasone dell'apoptosi indotta da TRAIL in cellule <strong>di</strong><br />

carcinoma tiroideo<br />

15.50/16.15 Grohmann U (Perugia)<br />

Il catabolismo del triptofano come nuovo meccanismo d'azione dei glucocorticoi<strong>di</strong><br />

nell'infiammazione allergica delle vie respiratorie<br />

16.15/16.40 Cuzzocrea S (Messina)<br />

L’assenza del recettore PPAR- funzionale inibisce l’effetto antinfiammatorio dei<br />

glucocorticoi<strong>di</strong><br />

16.40/17.05 Cirino G (Napoli)<br />

I glucocorticoi<strong>di</strong> donatori <strong>di</strong> ossido nitrico (NO) mostrano proprietà farmacologiche che<br />

si traducono in benefici clinici<br />

17.05/17.30 Discussione<br />

55<br />

Simposio<br />

Angiogenesi tumorale e terapia antiangiogenica<br />

SALA 1<br />

15.00-17.30<br />

Moderatori: Ziche M (Siena) Spano PF (Brescia)<br />

15.00/15.30 Kerbel R (Toronto)<br />

Terapia antiangiogenica e ottimizzazione dell'efficacia della chemioterapia<br />

convenzionale<br />

15.30/16.00 Mochly-Rosen D (Stanford)<br />

La PKC influenza le funzioni vascolari e la crescita del tumore della prostata<br />

16.00/16.30 Melillo G (Frederick)<br />

Hypoxia Inducible Factor 1 (HIF-1) come bersaglio per la terapia antitumorale<br />

16.30/17.00 Ziche M (Pisa)<br />

Angiogenesi e infiammazione: il circolo vizioso <strong>di</strong> PGE2 e recettori tirosin chinasici<br />

17.00/17.30 Mini E (Firenze)<br />

Sviluppo clinico <strong>di</strong> enzastaurin, un inibitore della protein chinasi C beta: attualità e<br />

prospettive<br />

Realizzato con il contributo educazionale <strong>di</strong> Eli Lilly, Cell Therap. Europe<br />

pag_dx.indd 1 30/05/2007 2.15.01


Sessione ECM<br />

Simposio<br />

Lo stress nella patologia mentale: comportamento, neurobiologia<br />

e trattamento<br />

Moderatori: Riva MA (Milano) Serra M (Cagliari)<br />

SALA 2<br />

15.00-17.30<br />

15.00/15.25 Maccari S (Villeneuve d'Ascq)<br />

Lo stress prenatale ha effetti sulla plasticità cerebrale nella <strong>di</strong>scendenza adulta:<br />

<strong>di</strong>fferenze sessuali<br />

15.25/15.50 Serra M (Cagliari)<br />

Influenza dello stress cronico sui livelli <strong>degli</strong> steroi<strong>di</strong> neuroattivi, sulla plasticità e la<br />

funzione del recettore GABA A<br />

15.50/16.15 Gass P (Mannheim)<br />

Modelling depression through glucocorticoid receptor transgenic mice<br />

16.15/16.40 Dazzi L (Cagliari)<br />

Controllo farmacologico delle alterazioni indotte dallo stress nel rilascio dei<br />

neurotrasmettitori<br />

16.40/17.05 Riva MA (Milano)<br />

Stress, plasticità neuronale e vulnerabilità alle malattie psichiatriche<br />

17.05/17.30 Discussione<br />

56<br />

Cre<strong>di</strong>ti ECM assegnati 2<br />

Simposio<br />

Atomoxetina, nuova alternativa terapeutica per il trattamento del<br />

<strong>di</strong>sturbo da deficit dell'attenzione e iperattività (ADHD)<br />

Moderatori: Biggio G (Cagliari) Zuddas A (Cagliari)<br />

15.00/15.30 Biggio G (Cagliari)<br />

Cosa succede nel cervello <strong>di</strong> un bambino con ADHD?<br />

15.30/15.55 Masi G (Pisa)<br />

Un bambino con ADHD sarà anche un uomo con ADHD?<br />

SALA 4<br />

15.00-17.30<br />

15.55/16.20 Bymaster F (In<strong>di</strong>anapolis)<br />

Atomoxetina, un nuovo farmaco non-psicostimolante per il trattamento del ADHD<br />

16.20/16.45 Zuddas A (Cagliari)<br />

Risultati <strong>di</strong> un trial a lungo termine sull'impiego <strong>di</strong> atomoxetina nella prevenzione delle<br />

reci<strong>di</strong>ve nel ADHD<br />

16.45/17.10 Dell'Agnello G (Firenze)<br />

Risultati preliminari <strong>di</strong> uno stu<strong>di</strong>o italiano sull'efficacia <strong>di</strong> atomoxetina in pazienti con<br />

ADHD e Disturbo Oppositivo Provocatorio (ODD)<br />

17.10/17.30 Discussione e Questionario ECM<br />

Realizzato con il contributo educazionale <strong>di</strong> Eli Lilly<br />

pag_sx.indd 1 30/05/2007 2.18.56


Sessione <strong>di</strong> Comunicazioni Orali<br />

Nuove acquisizioni sulla farmacologia <strong>di</strong> genere<br />

SALA 5<br />

15.00-17.30<br />

Moderatori: Eva C (<strong>Torino</strong>) Serra G (Sassari)<br />

Trabace Luigia 1 , Colaianna M. 1 , Castrignanò S. 1 , Cassano T. 1 , Tucci P. 1 , Cuomo V. 2<br />

1 Dip. Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Foggia; 2 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia V.<br />

Erspamer, Università <strong>di</strong> Roma “La Sapienza”<br />

Differenze <strong>di</strong> genere nella modulazione indotta da ossido nitrico della trasmissione dopaminergica<br />

nella corteccia prefrontale <strong>di</strong> ratto.<br />

Morale Maria Concetta 1 , Giaquinta G. 1 , Caniglia S. 1 , L’Episcopo F. 1 , Tirolo C. 1 , Testa N. 1 ,<br />

Arcieri P. 1 , Marchetti B. 1.2<br />

1 OASI Scientific Institute (IRCCS) Troina (EN), 2 Dipartimento Farmacologia Fac Me<strong>di</strong>cina Università <strong>di</strong><br />

Sassari<br />

Stato infiammatorio “pre-esistente”, genere e deficienza <strong>di</strong> estrogeni: una finestra terapeutica per il<br />

targeting farmacologico della malattia <strong>di</strong> Parkinson.<br />

Patacchioli Francesca Romana, Monnazzi P., Martelletti P. 1 , Simeoni S.<br />

Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia V. Erspamer, Università La Sapienza, Roma; 1 Dip.<br />

Me<strong>di</strong>cina Interna, Università La Sapienza, Roma<br />

Effetti della tossina botulinica tipo-A su in<strong>di</strong>ci ormonali <strong>di</strong> benessere fisico in donne affette da<br />

emicrania cronica.<br />

Zavatti Manuela, Montanari C., Geminiani E., Ricchi L., Corsi L., Zanoli P.<br />

Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena e Reggio Emilia<br />

Influenza della ferutinina sul comportamento sessuale del ratto femmina.<br />

57<br />

Canu Silvia 1 , Carta S. 1 , Loizzo S. 2 , Guarino I. 1 , Carru C. 3 , Zinellu A. 3 , Loizzo A. 2 , Franconi F. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Sassari; 2 Istituto Superiore <strong>di</strong> Sanità, Roma;<br />

3 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Sassari, Istituto Nazionale delle Biostrutture e<br />

Biosistemi (INBB), Osilo- Sassari<br />

L’handling neonatale induce un incremento nella curva <strong>di</strong> incremento <strong>di</strong> peso corporeo <strong>di</strong> entrambi i<br />

sessi.<br />

Moderatori: Pataccioli FR (Roma) Viano I (Novara)<br />

Vicentini Lucia M, Cattaneo M.G., Chini B. 1<br />

Dipartimento <strong>di</strong> Farmacologia, Milano; 1 CNR, Centro <strong>di</strong> Farmacologia Cellulare e Molecolare, Milano<br />

Nuovi possibili ruoli patofisiologici per l’ossitocina.<br />

Malorni Walter 1 , Coinu R. 2 , Carta S. 2 , Campesi I. 2 , Straface E. 1 , Matarrese P. 1 , Franconi F. 2<br />

1 Dipartimento del Farmaco, Istituto Superiore <strong>di</strong> Sanità, Roma; 2 Dipartimento <strong>di</strong> Scienze Fisiologiche,<br />

Biochimiche e Cellulari, Università <strong>di</strong> Sassari<br />

Cellule muscolari lisce vasali: stato redox e <strong>di</strong>fferenze <strong>di</strong> genere.<br />

Cignarella Andrea 1,2 , Bolego C. 1 , Vegeto E. 1 , Pelosi V. 1,2 , Meda C. 1 , Maggi A. 1<br />

1 Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano; 2 Dipartimento <strong>di</strong> Farmacologia ed<br />

Anestesiologia, Università <strong>di</strong> Padova<br />

Il recettore alfa per gli estrogeni è implicato nella regolazione dell’omeostasi del glucosio e nella<br />

risposta vascolare alle citochine infiammatorie nel topo.<br />

pag_dx.indd 1 30/05/2007 2.20.37


Marini Herbert 1 , Minutoli L. 2 , Polito F. 2 , Bitto A. 2 , Altavilla D. 2 , Frisina N. 3 , D’Anna R. 5 ,<br />

Lubrano C. 5 , Adamo E.B. 1 , Caputi A.P. 2 , Squadrito F. 2<br />

1 Dipartimento <strong>di</strong> Scienze Biochimiche, Fisiologiche e della Nutrizione, Sezione <strong>di</strong> Fisiologia e<br />

Nutrizione Umana, Università <strong>di</strong> Messina, 2 Dipartimento Clinico-Sperimentale <strong>di</strong> Me<strong>di</strong>cina e<br />

Farmacologia, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Messina, 3 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Interna,<br />

Università <strong>di</strong> Messina, 4 Dipartimento <strong>di</strong> Scienze Ostetriche e Ginecologiche, Università <strong>di</strong> Messina;<br />

5 Dipartimento <strong>di</strong> Fisiopatologia Me<strong>di</strong>ca, Università “La Sapienza”, Roma<br />

Effetti del fitoestrogeno genisteina sul metabolismo osseo in donne osteopeniche, in post-menopausa:<br />

un trial clinico randomizzato.<br />

Aviello Gabriella 1 , Ernst E. 2 , Capasso R. 1 , Capasso F. 1 , Borrelli F. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II <strong>di</strong> Napoli; 2 Complementary<br />

Me<strong>di</strong>cine, Peninsula Me<strong>di</strong>cal School, Universities of Exeter and Plymouth, 25 Victoria Park Road,<br />

Exeter EX2 4NT, UK.<br />

Revisione sistematica sull’efficacia e sicurezza della Cimicifuga racemosa.<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Farmaci antitumorali<br />

SALA 7<br />

15.00-17.30<br />

58<br />

Moderatori: Baral<strong>di</strong> M (Modena) Onali PL (Cagliari)<br />

Ayrol<strong>di</strong> Emira, Bastianelli A., Marchetti C., Velar<strong>di</strong> E., Agostani M., Donato V., Bruscoli S.,<br />

Riccar<strong>di</strong> C.<br />

Istituto <strong>di</strong> Farmacologia, Dipartimento Med. Clinica e Sperimentale, Università <strong>di</strong> Perugia<br />

Gilz modula negativamente proliferazione e segnali oncogenici <strong>di</strong>pendenti dall’attivazione <strong>di</strong> ras.<br />

Baiula Monica, Di Toro R., Spampinato S.<br />

Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Bologna<br />

L’espressione del fattore <strong>di</strong> trascrizione rest, ridotta in cellule <strong>di</strong> neuroblastoma esposte a pma, è<br />

stabilizzata da un inibitore delle proteasi, correlandosi in senso inverso al <strong>di</strong>fferenziamento neuronale<br />

Corsi Lorenzo, Geminiani E., Ricchi L., Baral<strong>di</strong> M.<br />

Dip. Scienze Biome<strong>di</strong>che Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Modena e Reggio Emilia<br />

CINSPAN Consorzio Interuniversitario Nazionale per lo <strong>Stu<strong>di</strong></strong>o dei Principi Attivi Naturali<br />

Coinvolgimento dei recettori periferici delle benzo<strong>di</strong>azepine nei processi proliferativi tumorali e nella<br />

produzione <strong>di</strong> ROS.<br />

Fimognari Carmela, Lenzi M., Cantelli-Forti G., Hrelia P.<br />

Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Bologna<br />

Percorsi molecolari alla base dell’attività antileucemica del sulforafane.<br />

De Francia Silvia 1 , De Martino F. 1 , Pirro E. 1 , Piccione F. 1 , Sprio A.E. 1 , Di Carlo F. 1 , Mussa<br />

M.V. 2 , Daffara F. 3 , Reimondo G. 3 , Zaggia B. 3 , Terzolo M. 3 , Angeli A. 3<br />

1 Laboratorio <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Scienze Cliniche e Biologiche, Università <strong>di</strong> <strong>Torino</strong>,<br />

2 Scuola Infermieri, Università <strong>di</strong> <strong>Torino</strong>, 3 Me<strong>di</strong>cina Interna, Dipartimento <strong>di</strong> Scienze Cliniche e<br />

Biologiche, Università <strong>di</strong> <strong>Torino</strong><br />

<strong>Stu<strong>di</strong></strong>o prospettico <strong>degli</strong> effetti biochimici della somministrazione <strong>di</strong> mitotane in pazienti con carcinoma<br />

corticosurrenalico.<br />

Rosa Arianna Carolina, Gallicchio M., Dianzani C., Brucato L., Collino M., Fantozzi R.<br />

Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale. Università <strong>di</strong> <strong>Torino</strong><br />

Effetti del celecoxib sull'espressione <strong>di</strong> ICAM-1 e VCAM-1 nelle HT29.<br />

pag_sx.indd 1 30/05/2007 2.29.55


D’Acunto Cosimo Walter, Festa M., Tosco A., Rodriguez M., Petrella A., Parente L.<br />

Dipartimento <strong>di</strong> Scienze Farmaceutiche, Università <strong>di</strong> Salerno<br />

Effetti del nuovo inibitore <strong>di</strong> deacetilasi FR235222 in cellule promonocitiche umane U937: Ruolo della<br />

Annessina A1.<br />

Di Paolo Antonello 1 , Amatori F. 1 , Lencioni M. 2 , Bocci G. 1 , Orlan<strong>di</strong>ni C. 2 , Ciofi L. 1 , Lastella M. 1 ,<br />

Falcone A. 3 , Ricci S. 2 , Del Tacca M. 1 , Danesi R. 1<br />

1 Divisione <strong>di</strong> Farmacologia e Chemioterapia, Dipartimento <strong>di</strong> Me<strong>di</strong>cina Interna, Università <strong>di</strong> Pisa;<br />

2 Unità Operativa <strong>di</strong> Oncologia Me<strong>di</strong>ca, Azienda Ospedaliera Universitaria Pisana, Pisa; 3 Unità Operativa<br />

<strong>di</strong> Oncologia Me<strong>di</strong>ca, Ospedale Civile, Livorno<br />

L’esposizione a 5-fluorouracile è associata alla sopravvivenza libera da malattia in pazienti affetti da<br />

carcinoma colorettale in trattamento con chemioterapia a<strong>di</strong>uvante.<br />

Bellik Ly<strong>di</strong>a 1 , Parenti A. 1 , Vinci M.C. 1 , Gerlini G. 2 , Pantalone D. 3 , Ledda F. 1<br />

1 Laboratorio <strong>di</strong> Farmacologia Vascolare, Dipartimento <strong>di</strong> Farmacologica Clinica e Preclinica,<br />

2 Dipartimento <strong>di</strong> Scienze Dermatologiche, 3Dipartimento <strong>di</strong> Area Critico Me<strong>di</strong>co Chirurgica, Università<br />

<strong>di</strong> Firenze<br />

Effetto dei trattamenti convenzionali sulle cellule dendritiche in pazienti con cancro colorettale.<br />

Mognetti Barbara 1 , Berta G.N. 1 , Spadaro M. 1 , Cavallo F. 1 , Barberis A. 1 , Papotti M. 1 , Amici A. 2 ,<br />

Iezzi M. 3 , Musiani P. 3 , Forni G. 1 , Di Carlo F. 1<br />

1 Dipartimento Scienze Cliniche e Biologiche, Università <strong>di</strong> <strong>Torino</strong>; 2 Dipartimento <strong>di</strong> Biologia Molecolare,<br />

Cellulare e Animale, Università <strong>di</strong> Camerino; 3 Centro <strong>di</strong> ricerche sull’invecchiamento Fondazione<br />

Università “Gabriele D'Annunzio Chieti<br />

Valutazione preclinica <strong>di</strong> un nuovo approccio terapeutico: la vaccinazione a dna protegge dal<br />

carcinoma squamoso orale chimicamente indotto.<br />

59<br />

Simposio<br />

I modelli animali nella ricerca biome<strong>di</strong>ca<br />

(<strong>SIF</strong> - EBRA)<br />

SALA 8<br />

15.00-17.30<br />

Moderatori: Jori A (Milano) Drago F (Catania)<br />

15.00/15.20 Meneguz A (Milano)<br />

L'impiego dei modelli animali nella ricerca preclinica secondo le GLP<br />

15.20/15.40 Collu M (Cagliari)<br />

Modelli animali in psichiatria e neuropsicofarmacologia: vali<strong>di</strong>tà e limiti<br />

15.40/16.00 Cerbai E (Firenze)<br />

I modelli animali nella ricerca in area car<strong>di</strong>ovascolare<br />

16.00/16.20 Blan<strong>di</strong>zzi C (Pisa)<br />

Modelli animali in gastroenterologia<br />

16.20/16.40 Morigi M (Bergamo)<br />

Cellule staminali e modelli animali <strong>di</strong> danno renale<br />

16.40/17.30 Discussione<br />

Assemblea dei soci<br />

AUDITORIUM<br />

17.30-19.30<br />

pag_dx.indd 1 30/05/2007 2.32.10


Simposio<br />

Target molecolari del dolore cronico<br />

SALA 1<br />

08.30-11.00<br />

Moderatori: Canonico PL (Novara) Sortino MA (Catania)<br />

08.30/08.50 Negri L (Roma)<br />

Meccanismi peptidergici della nocicezione<br />

08.50/09.10 Maione S (Napoli)<br />

Meccanismi <strong>di</strong> plasticità nei nuclei sopraspinali che regolano la soglia del dolore<br />

09.10/09.30 Nicoletti F (Roma)<br />

I meccanismi periferici e midollari <strong>di</strong> sensibilizzazione nocicettiva come target <strong>di</strong><br />

farmaci analgesici<br />

09.30/09.50 Cipollone F (Chieti)<br />

Espressione <strong>di</strong> COX-2 in piastrine e monociti come potenziale base del fallimento della<br />

terapia con ASA nel paziente <strong>di</strong>abetico<br />

09.50/10.10 Blan<strong>di</strong>zzi C (Pisa)<br />

Farmaci inibitori selettivi della COX-2 e meccanismi <strong>di</strong> protezione e riparazione della<br />

mucosa gastrointestinale<br />

10.10/11.00 Discussione<br />

60<br />

Realizzato con il contributo educazionale <strong>di</strong> Pfizer<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Farmacologia <strong>di</strong> Scienze<br />

SALA 2<br />

08.30-12.15<br />

Moderatori: Maura G (Genova) Pedata F (Firenze)<br />

Carmignani Marco 1 , Cesare P. 1 , Fanelli R. 2 , Valle G. 3 , Volpe A.R. 1<br />

1 Dipartimento <strong>di</strong> Biologia <strong>di</strong> Base ed Applicata, Sezione <strong>di</strong> Farmacologia e Tossicologia, Università <strong>di</strong><br />

L’Aquila; 2 IRCCS – Casa Sollievo della Sofferenza - Sezione <strong>di</strong> Car<strong>di</strong>ologia, S. Giovanni Rotondo (FG);<br />

3 IRCCS – Casa Sollievo della Sofferenza - Sezione <strong>di</strong> Me<strong>di</strong>cina Nucleare, S. Giovanni Rotondo (FG)<br />

Livelli critici <strong>di</strong> ipoperfusione splancnica: fattore critico <strong>di</strong> shock ipo<strong>di</strong>namico irreversibile da aumento<br />

<strong>di</strong> nitrossido plasmatico indotto da rilascio intestinale <strong>di</strong> encefalite.<br />

Giar<strong>di</strong>na Silvana, Marzani B., Marzatico F.<br />

Dipartimento <strong>di</strong> Scienze Fisiologiche e Farmacologiche Cellulari e Molecolari, Sez. Farmacologia e<br />

Biotecnologie Farmacologiche; Università <strong>di</strong> Pavia<br />

Valutazione “in vivo” <strong>degli</strong> enzimi antiossidanti e della perossidazione lipi<strong>di</strong>ca a <strong>di</strong>fferenti livelli dello<br />

strato corneo umano.<br />

Botti Francesca 1 , Ottolina A. 2 , Marcuzzo S. 1 , Mennini T. 3 , Parati E. 2 , Tonini M. 1 , Curti D. 1<br />

1 Dipartimento <strong>di</strong> Scienze Fisiologiche e Farmacologiche Celllari e Molecolari, Università <strong>di</strong> Pavia;<br />

2 Istituto Neurologico “C. Besta”, Milano; 3 Istituto Mario Negri, Milano<br />

Cellule staminali adulte come strumento per lo stu<strong>di</strong>o dei meccanismi responsabili del processo<br />

neurodegenerativo in topi con mutazione del gene per la proteina Vps54.<br />

pag_sx.indd 1 30/05/2007 2.36.18


Gessi Stefania 1 , Merighi S. 1 , Varani K. 1 , Fogli E. 1 , Sacchetto V. 1 , Benini A. 1 , Mirandola P. 2 ,<br />

Leung E. 3 , Mac Lennan S. 3 , Feo C. 4 , and Borea P.A. 1<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale Sez. Farmacologia, Università <strong>di</strong> Ferrara; 2 Dip. <strong>di</strong><br />

Anatomia Umana, Farmacologia e Me<strong>di</strong>cina Forense, Ist. <strong>di</strong> Anatomia Umana, Osp. Maggiore,<br />

Università <strong>di</strong> Parma; 3 King Pharm. Res. and Dev., Inc., Cary, North Carolina, 4 Dipartimento <strong>di</strong><br />

Chirurgia, Anestesiologia e Ra<strong>di</strong>ologia, Università <strong>di</strong> Ferrara<br />

Recettori dell’adenosina in tessuti tumorali e in linee cellulari <strong>di</strong> colon: “focus” sul recettore A3.<br />

Quintieri Luigi 1 , Fantin M 1 , Rosato A 2,3 , Caruso M 4 , Geroni C 4 , Nassi A 1 , Floreani M 1<br />

1 Dipartimento <strong>di</strong> Farmacologia ed Anestesiologia, Università <strong>di</strong> Padova; 2 Dipartimento <strong>di</strong> Scienze<br />

Oncologiche e Chirurgiche, Università <strong>di</strong> Padova; 3 Istituto Oncologico Veneto, Padova; 4 Nerviano<br />

Me<strong>di</strong>cal Sciences S.r.l., Nerviano<br />

Confronto interspecie della biotrasformazione epatica dell’antitumorale nemorubicina nel suo<br />

metabolita attivo PNU-159682.<br />

Monti Elena, Molteni R., Marras E., Perletti G., Ravizza R., Garibol<strong>di</strong> M.B.<br />

Dipartimento Biologia Strutturale e Funzionale, Università dell’Insubria<br />

L’inibizione dell’espressione <strong>di</strong> hif-1 me<strong>di</strong>ante rna interference potenzia l’azione citotossica della<br />

doxorubicina in cellule <strong>di</strong> adenocarcinoma del colon umano.<br />

Intervallo 10.00/10.15<br />

Moderatori: Parolaro D (Varese) Sanna E (Cagliari)<br />

Capurro Valeria, Braida D., Zani A., Sala M.<br />

Dipartimento <strong>di</strong> Farmacologia, Chemioterapia e Tossicologia me<strong>di</strong>ca Università <strong>di</strong> Milano<br />

Coinvolgimento del sottotipo recettoriale CB1 nella risposta emozionale indotta dalla salvinorina a nel<br />

ratto.<br />

61<br />

Rubino Tiziana, Viganò D., Realini N. Guidali C., Parolaro D .<br />

DBSF e Centro <strong>di</strong> Neuroscienze, Università dell’Insubria<br />

Endocannabinoi<strong>di</strong> ed ansia: ruolo della corteccia prefrontale.<br />

Follesa Paolo 1,2 , Biggio F.1, Gorini G. 1 , Caria S., Mostallino M.C. 3 , Murru L. 1 , Sanna E. 1,2 ,<br />

Biggio G. 1,2,3<br />

1 Dipartimento <strong>di</strong> Biologia Sperimentale, Sezione <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari; 2 Centro <strong>di</strong><br />

Eccellenza per la Neurobiologia delle Dipendenze, 3 CNR Istituto <strong>di</strong> Neuroscienze, Unità <strong>di</strong><br />

Neuropsicofarmacologia, Cagliari<br />

Riduzione dell’espressione genica della subunità e della sensibilità del recettore GABA A<br />

all’allopregnanolone indotta dall’interruzione <strong>di</strong> un trattamento cronico con progesterone.<br />

Comelli Francesca 1 , Colleoni M. 2 , Giagnoni G. 1 , Costa B. 1<br />

1 Dipartimento <strong>di</strong> Biotecnologie Bioscienze, Università Milano-Bicocca; 2 Dipartimento <strong>di</strong><br />

Farmacologia, Università <strong>di</strong> Milano<br />

Effetto antiiperalgesico <strong>di</strong> un estratto <strong>di</strong> cannabis sativa in un modello <strong>di</strong> dolore neuropatico nel ratto:<br />

meccanismi implicati.<br />

Cipriani Sara 1 , Melani A. 1 , Gianfriddo M. 2 , Vannucchi M.G. 3 , Pedata F. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica M.A. Mancini, Università <strong>di</strong> Firenze; 2 Siena Biotech<br />

S.p.A., Siena; 3 Dipartimento <strong>di</strong> Anatomia, Istologia e Me<strong>di</strong>cina Forense, Università <strong>di</strong> Firenze<br />

Effetto dell’antagonismo selettivo del recettore adenosinico A 2A sul comportamento motorio e<br />

sull’espressione dell’ossido nitrico sintetasi neuronale nello striato <strong>di</strong> topi transgenici per la corea <strong>di</strong><br />

Huntington.<br />

pag_dx.indd 1 30/05/2007 2.38.07


Marcoli Manuela 1, Cervetto C. 1 , Paluzzi P. 1 , Guarnieri S. 1 , Maura G. 1,2<br />

1Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Sezione <strong>di</strong> Farmacologia e Tossicologia, Università <strong>di</strong><br />

Genova; 2Centro <strong>di</strong> Eccellenza per la Ricerca Biome<strong>di</strong>ca, Università <strong>di</strong> Genova<br />

Controllo da parte <strong>di</strong> cGMP dell’attivazione <strong>di</strong> recettori kainato nella corteccia cerebellare <strong>di</strong> ratto.<br />

Casale Federico, Ferretti C.<br />

Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale, Università <strong>di</strong> <strong>Torino</strong><br />

Modulazione colinergica dell’espressione <strong>di</strong> Egr-1 in cellule <strong>di</strong> neuroblastoma umano SK-n-BE.<br />

Corsini Daniela 1 , Alboni S. 1 , Blom J.M.C. 2 , Benatti C. 1 , Caggia F. 1 , Barden N. 3 , Brunello N. 1 ,<br />

Tascedda F. 1<br />

1 Dipartimento Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Modena e Reggio Emilia; 2 Dipartimento Pe<strong>di</strong>atria,<br />

Università <strong>di</strong> Modena e Reggio Emilia; 3 CHUL Research Center, Laval University, Quebec, Canada<br />

Regolazione dell’attività trascrizionale in ippocampo <strong>di</strong> topi transgenici per il recettore dei<br />

glucocorticoi<strong>di</strong> <strong>di</strong> tipo II: effetto dello stress da restraint.<br />

62<br />

Sessione ECM<br />

Simposio<br />

Terapia ormonale sostitutiva: se, quando, per quanto e perchè<br />

(<strong>SIF</strong> - AIGE)<br />

Moderatori: Genazzani AR (Pisa) Melis GB (Cagliari)<br />

SALA 3<br />

08.30-11.00<br />

08.30/08.50 Simoncini T (Pisa)<br />

Prevenzione car<strong>di</strong>ovascolare dopo la menopausa: quale ruolo per la terapia ormonale<br />

sostitutiva?<br />

08.50/09.10 Concas A (Cagliari)<br />

Neurosteroi<strong>di</strong>, plasticità neuronale e menopausa<br />

09.10/09.30 Genazzani AR (Pisa)<br />

Effetti centrali <strong>degli</strong> steroi<strong>di</strong>: dai sintomi alla prevenzione<br />

09.30/09.50 Nappi R (Pavia)<br />

Menopausa e sessualità: una terapia per la persona<br />

09.50/10.10 Paoletti A (Cagliari)<br />

L'ottimizzazione della dose e la personalizzazione del progestinico<br />

10.10/11.00 Discussione<br />

pag_sx.indd 1 30/05/2007 2.40.17


Simposio<br />

Aspetti cellulari e molecolari del precon<strong>di</strong>zionamento e<br />

postcon<strong>di</strong>zionamento ischemico: basi <strong>di</strong> intervento farmacologico<br />

SALA 5<br />

08.30-11.00<br />

Moderatori: Annunziato L (Napoli) Moroni F (Firenze)<br />

08.30/09.45 Pellegrini GD (Firenze)<br />

Modelli <strong>di</strong> precon<strong>di</strong>zionamento ischemico in fettine ippocampali: ruolo dei recettori al<br />

glutammato e della poli(ADP-ribosio) polimerasi<br />

09.45/10.00 Pizzi M (Brescia)<br />

Specificità dei complessi trascrizionali NF-kappaB nella regolazione della vulnerabilità<br />

all'ischemia cerebrale<br />

10.00/10.15 Scorziello A (Napoli)<br />

La neuroprotezione indotta dal Precon<strong>di</strong>zionamento anossico nei neuroni corticali è<br />

me<strong>di</strong>ata dall’NO e dalla Mn-SOD<br />

10.15/10.30 Pignataro G (Napoli)<br />

Postcon<strong>di</strong>tioning ischemico cerebrale, caratterizzazione molecolare <strong>di</strong> una nuova<br />

strategia neuroprotettiva<br />

Sessione ECM<br />

Simposio<br />

Basi farmacocinetiche/farmaco<strong>di</strong>namiche (PK/PD) per il corretto<br />

uso dei farmaci antimicrobici<br />

(<strong>SIF</strong> - SIC)<br />

Moderatori: Mazzei T (Firenze) Cricelli C (Firenze)<br />

08.30/09.00 Scaglione F (Milano)<br />

Basi (PK/PD) per il corretto uso dei farmaci antimicrobici<br />

09.00/09.30 Novelli A (Firenze)<br />

Variabili (PK/PD) in rapporto al paziente e agli organi<br />

09.30/10.00 Rossi A (Narni)<br />

Applicabilità dei criteri (PK/PD) nella pratica me<strong>di</strong>ca<br />

10.00/11.00 Discussione<br />

SALA 6<br />

08.30-11.00<br />

63<br />

pag_dx.indd 1 30/05/2007 2.41.38


64<br />

Sessione ECM<br />

Simposio<br />

Monossido <strong>di</strong> azoto (NO) ed infiammazione: prospettive<br />

terapeutiche<br />

Moderatori: Cantoni O (Urbino) Masini E (Firenze)<br />

SALA 7<br />

08.30-11.00<br />

08.30/08.50 Nisoli E (Milano)<br />

Ossido nitrico e mitocondriogenesi: rilevanza fisiopatologica nello sviluppo della<br />

sindrome metabolica<br />

08.50/09.10 Cantoni O (Urbino)<br />

La comprensione dei meccanismi <strong>di</strong> sopravvivenza delle cellule infiammatorie a<br />

NO/perossinitrito: un primo passo per lo sviluppo <strong>di</strong> nuove strategie farmacologiche<br />

per la terapia dell'infiammazione<br />

09.10/09.30 Clementi E (Milano)<br />

Ruolo del monossido <strong>di</strong> azoto e del controllo della infiammazione nella terapia delle<br />

<strong>di</strong>strofie muscolari<br />

09.30/09.50 Cirino G (Napoli)<br />

NOS endoteliale, sfingosina-1-fosfato ed infiammazione<br />

09.50/10.10 Madeddu P (Bristol)<br />

Statine che rilasciano ossido nitrico mostrano attività antinfiammatorie e riparative in<br />

modelli sperimentali <strong>di</strong> malattie car<strong>di</strong>ovascolari<br />

10.10/10.30 Masini E (Firenze)<br />

Monossido d'azoto e ceramide: un nuovo target per il controllo dell'infiammazione e<br />

dell'iperreattività bronchiale<br />

10.30/11.00 Discussione<br />

Sessione <strong>di</strong> Comunicazioni Orali<br />

Neurodegenerazione e neuroprotezione<br />

SALA 5<br />

11.00-13.00<br />

Moderatori: Memo M (Brescia) Parente L (Salerno)<br />

Marchetti Bianca 1,2 , Tirolo C. 1 , L’Episcopo F. 1 , Testa N. 1 , Caniglia S. 1 , Serra P.A. 2 , Rocchitta<br />

G. 2 , Giaquinta G. 1 , Morale M.C. 1 , Martino G. 3 , Plachino S. 3<br />

1 OASI Inst. (IRCCS) Troina (EN); 2 Dipartimento Farmacologia, Università <strong>di</strong> Sassari; 3 Unità <strong>di</strong><br />

Neuroimmunologia, Dipartimento <strong>di</strong> Neurologia e Fisiologia, San Raffaele, Milano<br />

Plasticità dei precursori neurali della regione subventricolare (SVZ) alla neurotossina MPTP:<br />

correlazione con la denervazione e reinnervazione nigrostriatale della SVZ.<br />

Serra Pier Andrea 1 , Migheli R. 1 , Rocchitta G. 1 , Bazzu G. 1 , Calia G. 1 , L‘Episcopo F. 3 ,<br />

Esposito G. 1 , Plachino S. 2 , Marchetti B. 1,3 , Miele E. 1<br />

1Dipartimento <strong>di</strong> Farmacologia, Ginecologia e Ostetricia, Sez. Farmacologia, Università <strong>di</strong> Sassari;<br />

2Dipartimento <strong>di</strong> Neuroscienze, Istituto scientifico San Raffaele, Milano; 3OASI (IRCCS) Istituto per la<br />

ricerca e la cura del ritardo mentale e dell’invecchiamento celebrale, Sez. Neurofarmacologia, Troina<br />

(EN)<br />

Il ciclo dell’acido ascorbico/acido deidroascorbico nelle cellule staminali provenienti dalla regione<br />

subventricolare del topo.<br />

pag_sx.indd 1 30/05/2007 2.43.27


Balduini Walter, Carloni S.<br />

Istituto <strong>di</strong> Farmacologia e Farmacognosia, Università <strong>di</strong> Urbino “Carlo Bo”<br />

Prolungato ruolo della morte cellulare <strong>di</strong> tipo necrotico dopo neurodegenerazione indotta da ipossiaischemia<br />

nel ratto neonato.<br />

Ferraro Luca 1 , Tomasini M.C. 1 , Fournier J. 2 , Mazza R. 1 , Manganelli S. 1 , Mazzoni E. 1 , Fuxe K. 3 ,<br />

Antonelli T. 1<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong><br />

Ferrara; 2 Sanofi-Aventis Recherche, Tolosa, Francia; 3 Dipartimento <strong>di</strong> Neuroscienze, Karolinska<br />

Institut, Stoccolma, Svezia<br />

Possibile ruolo dei recettori neurotensinergici nell’aumento dei livelli <strong>di</strong> glutammato e<br />

nell’apoptosi in seguito a deprivazione <strong>di</strong> ossigeno e glucosio in colture <strong>di</strong> neuroni corticali <strong>di</strong><br />

ratto.<br />

Gardoni Fabrizio, Marcello E., Epis R., Polli F., Malinverno M., Cattabeni F., Di Luca M.<br />

Dipartimento Scienze Farmacologiche – Università <strong>di</strong> Milano<br />

Nuovi targets <strong>di</strong> intervento farmacologico nella sinapsi eccitatoria glutammatergica.<br />

Moderatori: Nicoletti F (Roma) Tonon G (Cagliari)<br />

Battaglia Giuseppe 1 , Molinaro G. 1 , Riozzi B. 1 , Spinsanti P. 2 , Traficante A. 1 , Belluardo N. 3 ,<br />

Corti C. 4 , Nicoletti F. 1,2 , Bruno V. 1,2<br />

1 INM Neuromed, Pozzilli; 2 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, Università “La Sapienza”,<br />

Roma; 3 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Università <strong>di</strong> Palermo; 4 Dipartimento <strong>di</strong> Biologia,<br />

GlaxoSmithKline, Verona<br />

La neuroprotezione me<strong>di</strong>ata dagli agonisti dei recettori metabotropici per il glutammato del II gruppo<br />

richiede la presenza dei recettori mGlu3 ed è me<strong>di</strong>ata dalla produzione <strong>di</strong> fattori neurotrofici.<br />

65<br />

Ferrari-Toninelli Giulia 1 , Bonini S.A. 1 , Uberti D. 1 , Zambrano N. 2 , Russo T. 2 , Memo M. 1<br />

1 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che e Biotecnologie, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Brescia; 2 CEINGE<br />

biotecnologie avanzate, Dipartimento <strong>di</strong> Biochimica e Biotecnologie Me<strong>di</strong>che, Università <strong>di</strong> Napoli<br />

Federico II<br />

La via del segnale <strong>di</strong> Notch come nuovo target farmacologico per la terapia delle neuropatie<br />

periferiche.<br />

Morrone Luigi A. 1 , Nucci C. 2,3 , Rombolà C. 1 , Cavaliere F. 1 , Cerulli A. 2 , Maccarrone M. 4 ,<br />

Corasaniti M.T. 3 , Bagetta G. 1<br />

1 Dipartimento Farmacobiologico, Università della Calabria; 2 Dipartimento <strong>di</strong> Biopatologia e Diagnostica<br />

per Immagini, Cattedra <strong>di</strong> Ottica Fisiopatologica, Università <strong>di</strong> Roma “Tor Vergata”; 3 IRCCS Istituto<br />

Neurologico Fondazione C. Mon<strong>di</strong>no, Centro <strong>di</strong> Neurofarmacologia Sperimentale Mon<strong>di</strong>no-Tor Vergata,<br />

Laboratorio <strong>di</strong> Neurochimica, Roma; 4 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Teramo;<br />

5 Dipartimento <strong>di</strong> Scienze Farmacobiologiche, Università “Magna Graecia” <strong>di</strong> Catanzaro<br />

Ruolo del sistema endocannabinoide nei meccanismi alla base del danno retinico in un modello<br />

sperimentale <strong>di</strong> ischemia da aumentata pressione intraoculare nel ratto.<br />

Maullu Carlo 1 , Cabras C.A. 1 , Salis B. 1 , Onali P. 2 , Dedoni S. 2 , Marongiu C. 1 , Taylor G. 1 , Tonon<br />

G. 1<br />

1 Bio-Ker S.r.l., Pula (CA)<br />

2 Dipartimento <strong>di</strong> Neuroscienze BB Bro<strong>di</strong>e, Università <strong>di</strong> Cagliari<br />

Produzione <strong>di</strong> Interferone- (IFN- ) da E. coli e strategie per migliorare la bio<strong>di</strong>sponibilità e il profilo<br />

farmacologico.<br />

pag_dx.indd 1 30/05/2007 2.45.02


Cuzzocrea Salvatore 1,2 , Genovese T. 1,2 , Mazzon E. 1,2 , Crisafulli C. 1 , Di Paola R. 1,2 , Muià C. 1,2 ,<br />

Esposito E. 2,3 , Bramanti P. 2 , Zhang J. 4 , Caputi A.P. 1,2 , Wang Z-Q. 5<br />

1 Dipartimento Clinico Sperimentale e Farmacologia, Università <strong>di</strong> Messina; 2 IRCCS Centro Neurolesi<br />

"Bonino-Pulejo" Messina; 3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II Napoli;<br />

4 Guilford Pharmaceuticals Inc., Baltimore, USA; 5 International Agency for Research on Cancer, Lyon,<br />

France<br />

L’attività dell'enzima PARG me<strong>di</strong>a la risposta infiammatoria post-traumatica associata a trauma<br />

midollare.<br />

66<br />

Cre<strong>di</strong>ti ECM assegnati 4<br />

Corso <strong>di</strong> Aggiornamento<br />

Il trattamento a lungo termine della depressione: aspetti biologici<br />

e clinici<br />

Moderatori: Aguglia E (Trieste) Guazzelli M (Pisa)<br />

09.00/09.15 Aguglia E (Trieste)<br />

Apertura e introduzione<br />

09.15/10.00 Biggio G (Cagliari)<br />

Neurobiologia della remissione e reci<strong>di</strong>va dell'episo<strong>di</strong>o depressivo<br />

10.00/10.45 Torta R (<strong>Torino</strong>)<br />

La depressione fra psiche e soma: implicanze prognostiche e terapeutiche<br />

11.15/12.00 Mencacci C (Milano)<br />

Depressione: prevenzione delle ricorrenze<br />

12.00/12.30 Discussione<br />

SALA 4<br />

09.00-16.30<br />

12.30/13.00 Workshop<br />

Aguglia E (Trieste) Guazzelli M (Pisa) Mencacci C (Milano) Torta R (<strong>Torino</strong>)<br />

Presentazione dei casi clinici<br />

13.00/14.00 COLAZIONE DI LAVORO RISERVATA AI PARTECIPANTI<br />

14.00/16.00 Aguglia E (Trieste) Guazzelli M (Pisa) Mencacci C (Milano) Torta R (<strong>Torino</strong>)<br />

Elaborazione dei casi clinici<br />

16.00/16.30 Guazzelli M (Pisa)<br />

Conclusioni e questionario ECM<br />

Realizzato con il contributo educazionale <strong>di</strong> Wyeth<br />

Pausa caffè<br />

11.00-11.30<br />

pag_sx.indd 1 30/05/2007 2.55.01


Incontro con l'Esperto<br />

Update in <strong>di</strong>abetologia: gli inibitori del DPP-IV<br />

Moderatore: Carruba M (Milano)<br />

11.00/11.30 Mugelli A (Firenze)<br />

Il punto <strong>di</strong> vista del farmacologo<br />

11.30/12.00 Del Prato S (Pisa)<br />

Il punto <strong>di</strong> vista del <strong>di</strong>abetologo<br />

Sessione ECM<br />

SALA 3<br />

11.00-12.00<br />

Realizzato con il contributo educazionale <strong>di</strong> Novartis<br />

Compilazione Questionario ECM<br />

12.00-13.00<br />

Fine lavori del Congresso<br />

13.15<br />

67<br />

pag_dx.indd 1 30/05/2007 2.56.26


Senza titolo-3 1 28/05/2007 16.16.15


Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />

09.00/17.00 Corso <strong>di</strong><br />

Aggiornamento<br />

Il contributo della<br />

farmacologia al<br />

trattamento della<br />

depressione<br />

Mercoledì 6 giugno<br />

18.00/19.00 Cerimonia Inaugurale<br />

19.00/20.00 Lettura Inaugurale<br />

Three decades with three<br />

Swe<strong>di</strong>sh neuropeptides:<br />

focus on pain and<br />

depression<br />

20.00/22.00<br />

Cocktail <strong>di</strong> Benvenuto<br />

70<br />

pag_sx.indd 1 30/05/2007 3.35.00


Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />

Simposio<br />

Key research<br />

strategies in<br />

pharmacology:<br />

how to take<br />

water into dry<br />

pipe-lines<br />

Simposio<br />

Modulazione<br />

farmacologica<br />

dell'infiammazion<br />

e polmonare nella<br />

broncopneumopatia<br />

cronica<br />

ostruttiva<br />

Simposio<br />

Asma e patologie<br />

correlate<br />

Comunicazioni<br />

Orali<br />

Farmacologia<br />

delle sostanze<br />

d’abuso<br />

(08.30-11.30)<br />

Simposio<br />

Dalle scienze <strong>di</strong><br />

base alla scoperta<br />

<strong>di</strong> nuove terapie<br />

per l'epilessia<br />

Simposio<br />

<strong>SIF</strong> e informazione<br />

in<strong>di</strong>pendente sul<br />

farmaco<br />

Simposio<br />

Efficacia e sicurezza <strong>di</strong><br />

FANS tra<strong>di</strong>zionali e<br />

COXIB<br />

Simposio<br />

Modulazione<br />

farmacologica dei<br />

recettori P1<br />

08.30/11.00 Simposio<br />

Vecchi e nuovi<br />

antipsicotici a<br />

confronto<br />

11.00/11.30 Pausa caffè<br />

11.30/12.30 Lettura Plenaria<br />

Ruolo funzionale della<br />

neurogenesi nell'adulto<br />

12.30/13.30 Colazione <strong>di</strong> lavoro<br />

12.30/15.00 Sessione Poster<br />

Incontro con<br />

l'esperto<br />

Ricerca e sviluppo<br />

in antibioticoterapia:<br />

a che<br />

punto siamo?<br />

14.00/15.00 Incontro con<br />

l'esperto<br />

La vareniclina:<br />

nuove prospettive<br />

nella terapia del<br />

tabagismo<br />

Simposio<br />

Farmacoutilizzazione<br />

e<br />

appropriatezza<br />

d'uso dei farmaci<br />

Simposio<br />

La formazione<br />

specialistica in<br />

farmacologia<br />

Simposio<br />

<strong>Stu<strong>di</strong></strong> <strong>di</strong> sicurezza<br />

dei me<strong>di</strong>cinali<br />

biologici (anticorpi<br />

monoclonali)<br />

Tavola Rotonda<br />

Farmacologia <strong>di</strong><br />

genere: dal<br />

laboratorio alla<br />

società<br />

Simposio<br />

Infiammazioni e<br />

sindromi<br />

coronariche<br />

acute: stato<br />

dell'arte<br />

Simposio<br />

Nuove prospettive<br />

terapeutiche nel<br />

trattamento della<br />

depressione.<br />

L'approccio<br />

melatoninergico:<br />

dalla farmacologia<br />

all'evidenza clinica<br />

Comunicazioni Orali<br />

Giovani Farmacologi<br />

(15.00-20.00)<br />

Simposio<br />

Modulazione<br />

farmacologica dei<br />

recettori P2<br />

15.00/17.30 Simposio<br />

Nuove acquisizioni<br />

nella ricerca sui<br />

cannabinoi<strong>di</strong><br />

Simposio<br />

La malattia <strong>di</strong><br />

Parkinson: dalla<br />

biologia<br />

molecolare alla<br />

terapia<br />

Simposio<br />

Canali ionici<br />

come bersagli<br />

terapeutici per<br />

malattie<br />

genetiche e<br />

non-genetiche<br />

Simposio<br />

Meccanismi<br />

farmacologici che<br />

regolano la<br />

proliferazione e il<br />

<strong>di</strong>fferenziamento<br />

delle cellule<br />

staminali<br />

Simposio<br />

Targets cellulari e<br />

molecolari per lo<br />

sviluppo <strong>di</strong> nuove<br />

terapie in corso <strong>di</strong><br />

neuroAIDS<br />

Comunicazioni<br />

Orali<br />

Farmacologia del<br />

dolore e<br />

infiammazione<br />

Simposio<br />

Farmaci inibitori<br />

della pompa<br />

protonica e danno<br />

<strong>di</strong>gestivo indotto da<br />

FANS: aspetti<br />

farmacologici e<br />

clinici<br />

Simposio<br />

La neurobiologia e i<br />

trattamenti<br />

farmacologici del<br />

poliabuso<br />

17.30/19.30 Simposio<br />

Nuovi aspetti<br />

patogenetici e<br />

terapeutici della<br />

neurodegenerazione<br />

71<br />

Giovedì 7 giugno<br />

pag_dx.indd 1 27/05/2007 18.55.12


Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />

Simposio<br />

Farmacifarmacistifarmacie<br />

Simposio<br />

Meccanismi<br />

d'azione <strong>degli</strong><br />

antidepressivi:<br />

nuove acquisizioni<br />

Simposio<br />

I nuovi farmaci<br />

target-specifici in<br />

oncologia<br />

Simposio<br />

Sistema nervososistema<br />

immunitario tra<br />

interazione e<br />

integrazione:<br />

tempo per la<br />

neuro-immunofarmacologia?<br />

Simposio<br />

Nocicettina/<br />

orfanina FQ: dagli<br />

stu<strong>di</strong> <strong>di</strong> base alla<br />

clinica<br />

Comunicazioni<br />

Orali<br />

Farmacologia<br />

Car<strong>di</strong>ovascolare<br />

(08.30/11.30)<br />

Simposio<br />

Farmacologia dei<br />

recettori TRPV1<br />

(vanilloi<strong>di</strong>) nel sistema<br />

nervoso centrale e<br />

periferico<br />

Tavola Rotonda<br />

La prima del farmaco<br />

sull'uomo<br />

08.30/11.00 Simposio<br />

La cascata della via<br />

WNT come target delle<br />

patologie<br />

neurodegenerative<br />

Comunicazioni<br />

(09.50-11.00)<br />

11.00/13.00 Sessione Plenaria<br />

La ricerca clinica in<br />

Italia: attualità e<br />

prospettive<br />

12.30/17.30 Simposio<br />

Appropriatezza<br />

nella terapia<br />

farmacologica<br />

car<strong>di</strong>ovascolare<br />

Incontro con<br />

l'esperto<br />

Inibizione della<br />

corrente pacemaker<br />

IF:<br />

dall'elettrofisiologia<br />

alla pratica clinica<br />

Comunicazioni<br />

Orali<br />

Farmacologia<br />

car<strong>di</strong>ovascolare<br />

Venerdì 8 giugno<br />

13.00/14.00 Colazione <strong>di</strong> lavoro<br />

13.00/15.00 Sessione Poster<br />

Simposio<br />

I modelli animali<br />

nella ricerca<br />

biome<strong>di</strong>ca<br />

Comunicazioni<br />

Orali<br />

Farmaci<br />

antitumorali<br />

Comunicazioni<br />

Orali<br />

Nuove<br />

acquisizioni sulla<br />

Farmacologia <strong>di</strong><br />

Genere<br />

Simposio<br />

Atomoxetina,<br />

nuova alternativa<br />

terapeutica per il<br />

trattamento del<br />

<strong>di</strong>sturbo da deficit<br />

dell'attenzione e<br />

iperattività<br />

(ADHD)<br />

Simposio<br />

Lo stress nella<br />

patologia mentale:<br />

comportamento,<br />

neurobiologia e<br />

trattamento<br />

Simposio<br />

Angiogenesi tumorale<br />

e terapia<br />

antiangiogenica<br />

15.00/17.30 Simposio<br />

Glucocorticoi<strong>di</strong>,<br />

meccanismi molecolari<br />

ed efficacia<br />

antinfiammatoria ed<br />

immunosoppressiva<br />

17.30/19.30 Assemblea dei Soci<br />

72<br />

pag_sx.indd 1 27/05/2007 18.58.01


Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />

Simposio<br />

Monossido <strong>di</strong> azoto<br />

(NO) ed infiammazione:<br />

prospettive<br />

terapeutiche<br />

Simposio<br />

Basi<br />

farmacocinetiche/<br />

farmaco<strong>di</strong>namiche<br />

(PK/PD) per il<br />

corretto uso dei<br />

farmaci<br />

antimicrobici<br />

Simposio<br />

Aspetti cellulari e<br />

molecolari del<br />

precon<strong>di</strong>zionamento<br />

e<br />

postcon<strong>di</strong>zionamento<br />

ischemico: basi <strong>di</strong><br />

intervento<br />

farmacologico<br />

Simposio<br />

Terapia<br />

ormonale<br />

sostitutiva: se,<br />

quando, per<br />

quanto e<br />

perchè<br />

Comunicazioni Orali<br />

Farmacologia <strong>di</strong><br />

Scienze<br />

(08.30-12.15)<br />

08.30/11.00 Simposio<br />

Target molecolari<br />

del dolore cronico<br />

09.00/16.30 Corso <strong>di</strong><br />

Aggiornamento<br />

Il trattamento a<br />

lungo termine<br />

della<br />

depressione:<br />

aspetti biologici e<br />

clinici<br />

11.00/13.00 Comunicazioni<br />

Orali<br />

Neurodegenerazione<br />

e<br />

neuroprotezione<br />

11.00/11.30 Pausa caffè<br />

11.00/12.00 Lettura<br />

Plenaria<br />

Update in<br />

<strong>di</strong>abetologia:<br />

gli inibitori del<br />

DPP-IV<br />

73<br />

Sabato 9 giugno<br />

pag_dx.indd 1 30/05/2007 3.39.02


pag_sx.indd 1 28/05/2007 22.17.19


Sessione Poster<br />

Recettori e meccanismi <strong>di</strong> trasduzione del segnale<br />

Poster 1-20<br />

12.30-15.00<br />

1. Coupling of cannabinoid receptors to intracellular calcium mobilization in rat<br />

insulinoma B-cells<br />

Marini Pietro 1 , De Petrocellis L. 2 , Matias I. 2 , Schiano Moriello A. 2,3 , Starowicz K 3 , Cristino L. 2 ,<br />

Di Marzo V. 3<br />

1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />

Rome, Italy 2,3 Endocannabinoid Research Group, 2 Institute of Cybernetics and 3 Institute of<br />

Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio<br />

Olivetti, 80078, Pozzuoli, Naples, Italy<br />

2. Different striatal C-FOS expression following co-administration of delta-9-<br />

tetrahydrocannabinol with haloperidol or clozapine<br />

Casti Paola, a Marchese G. a , Sanna A. a , Casu G. a , Pinna Spada G. a , Pani L. a,b<br />

a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />

(CA), Italy. b C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o Neuroscienze<br />

PharmaNess S.c.a r.l.<br />

76<br />

3. Altered endocannabinoid-me<strong>di</strong>ated synaptic plasticity in hippocampal neurons in<br />

obesity<br />

1 Massa Federico, 1,2 Mancini G., 2 Pagotto U., 1 Lutz Beat<br />

1 Department of Physiological Chemistry, Johannes Gutenberg University, Mainz, Germany.<br />

2 Endocrinology Unit, Department of Internal Me<strong>di</strong>cine and Gastroenterology, S. Orsola-<br />

Malpighi General Hospital, Alma Mater University of Bologna, Bologna, Italy<br />

4. Caveolae/lipid rafts control signaling of CB1 cannabinoid receptor in human breast<br />

cancer cells<br />

Grimal<strong>di</strong> Clau<strong>di</strong>a, Sarnataro D., Cavallo P., Capasso A., Bifulco M.<br />

Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Italy<br />

5. Pharmacological characterization of single nucleotide polymorphisms for human CB2<br />

receptor<br />

Petrò Roberta, Beltramo M., Brusa R., Downey P., Jason S., Foglia C., Scandroglio P.,<br />

Reggiani A.<br />

Schering Plough Research Institute, Via Olgettina 58, 20132 Milano, Italy<br />

6. RITIRATO<br />

7. Lithium regulates neuronal excitability in rat hippocampus<br />

Murru Luca, Carta M., Pitzianti S., Corda G., Sanna E., Biggio G.<br />

Dept. Experimental Biology, Sect of Neuroscience, and Center of Excellence for the<br />

Neurobiology of Dependence. Cittadella Universitaria, SS 554 Km 4,500, 09042, Monserrato,<br />

Cagliari, Italy<br />

8. Thiocolchicoside inhibits the activity of various subtypes of recembinant GABA A<br />

receptors expressed in Xenoups Laevis oocyte<br />

Mascia Maria Paola a , Bachis E. b , Obili N. b , Maciocco E. a , Cocco G. A c , Sechi G.P. c , Biggio G. a,b<br />

a National Research Council, Institute of Neuroscience, Cagliari, Italy; b Department of<br />

Experimental Biology “B. Loddo”, University of Cagliari, Cagliari, Italy; c Neurological Clinic ,<br />

University of Sassari, Sassari, Italy<br />

pag_sx.indd 1 30/05/2007 3.45.04


9. Direct modulation of gabaergic transmission by thyroid hormones (THs) in<br />

hippocampus<br />

Losi Gabriele, Puia G.<br />

Dept. Biome<strong>di</strong>cal Science, University of Modena and Reggio Emilia, via Campi 287, Modena,<br />

ITALY<br />

10. Pregnancy and delivery change the gene expression of synaptic and extrasynaptic<br />

GABA A receptors in the rat hippocampus<br />

Mura Maria Luisa 1 , Mostallino M.C. 2 , Maciocco E. 2 , Biggio G. 1,2,3<br />

1 Departement of Experimental Biology, Section of Neuroscience, University of Cagliari,<br />

Monserrato (Cagliari), Italy; 2 CNR, Institute of Neuroscienze, Monserrato (Cagliari), Italy;<br />

3 Center of Excellence for the “Neurobiology of Drug Dependence”, University of Cagliari,<br />

Monserrato (Cagliari) Italy<br />

11. Plasticity of the gabaergic transmission in the rat hippocampus during pregnancy<br />

Murru Luca, Talani G., Serra V., Carta M., Sitzia F., Uras R., Sanna E., Biggio G.<br />

Dept. Experimental Biology, Sect of Neuroscience, and Center of Excellence for the<br />

Neurobiology of Dependence. Cittadella Universitaria, SS 554 Km 4,500, 09042, Monserrato,<br />

Cagliari, Italy<br />

12. Activation of group II metabotropic glutamate receptors prevents the <strong>di</strong>fferentiation<br />

of cultured neural progenitor cells isolated from the mouse subventricular zone into<br />

mature astrocytes<br />

Ciceroni Cinzia 1 , Mosillo P. 1 , Mastrantoni E. 1 , Magnotti M. C. 1 , Cappuccio I. 1,3 , Lupieri T. 1 ,<br />

Nicoletti F. 1,2 , Melchiorri D. 1<br />

1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />

Rome; 2 I.N.M. Neuromed, Pozzilli, Italy; 3 I.R.C.C.S. San Raffaele, Rome<br />

77<br />

13. In<strong>di</strong>vidual subtypes of metabotropic glutamate receptors regulates neural<br />

<strong>di</strong>fferentiation of cultured mouse embryonic stem cells<br />

Cappuccio Irene 1,2* , Sarichelou I. 1* , Costantino S. 1 , Ferranti F. 1 , Niccolini C. 1 , Nicoletti F. 1,3 ,<br />

Melchiorri D. 1<br />

1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />

Rome; 2 I.R.C.C.S. San Raffaele, Roma, 3 I.N.M. Neuromed, Pozzilli, Italy<br />

14. The human immunodeficiency virus-1 protein (TAT) modulates NMDA receptor<br />

function by acting at colocalized metabotropic glutamate receptor 1<br />

Musante Veronica 1 , Neri E. 1 , Severi P. 2 , Raiteri M. 1,3 , Pittaluga A. 1,3<br />

1 DI.ME.S, Pharmacology and Toxicology Section, Department of Experimental Me<strong>di</strong>cine,<br />

University of Genova, Italy, 2 Dision of Neurosurgery, Galliera Hospital, Genova, Italy, 3 Center<br />

of Excellence for Biome<strong>di</strong>cal Research, University of Genova, Italy<br />

15. Colocalization and functional interactions between presinaptic AMPA; NMDA and<br />

group I metabotropic glutamate receptors<br />

Neri Elisa, Musante V., Severi P., Pittaluga A., Raiteri M.<br />

1 DI.ME.S, Pharmacology and Toxicology Section, Department of Experimental Me<strong>di</strong>cine,<br />

University of Genova, Genova Italy; 2 Division of Neurosurgery, Galliera Hospital, Genova,<br />

Italy; 3 Center of Excellence for Biome<strong>di</strong>cal Research, University of Genova, Genova Italy<br />

16. Co-expression of metabotropic glutamate 1A (mGlu1A) receptor and cannabinoid 1<br />

(CB1) receptor immunoreactivity in the rat hippocampus<br />

Boscia Francesca, *Moroni F., Annunziato L. *Pellegrini-G. D.<br />

Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Napoli “Federico II”<br />

*Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze<br />

pag_dx.indd 1 30/05/2007 3.49.33


17. Biochemical and pharmacological evidences for (-)-epigallo catechin-3-gallate<br />

(EGCG) to link NMDA receptors in rat cortex<br />

Lograno Marco D., Romano M.R.<br />

Department of Pharmacobiology, University of Bari, Via E. Orabona, 4, 70125 Bari, Italy<br />

18. Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist<br />

sb-612111: in vitro stu<strong>di</strong>es<br />

1 Fischetti Carmela, 1 Spagnolo B., 1 Carra’ G., 1 Fantin M., 2 Hebbes C., 2 McDonald J., 2 Barnes A.<br />

1 Rizzi A., 1 Marzola G., 3 Trapella C., 3 Fanton G., 1 Morari M., 2 Lambert D., 1 Regoli D., 1 Calo’ G.<br />

1 Dept. of Pharmacology and 3 Dept of Pharmaceutical Science, University of Ferrara, Italy.<br />

2 Dept. of Car<strong>di</strong>ovascular Sciences, University of Leicester, UK<br />

19. Activation of nociceptin/orphanin FQ and classical opioid receptors in CHO cells<br />

expressing the CHIMERIC Galpha qi5 protein promotes calcium mobilization<br />

Camarda Valeria 1 , Molinari P. 2 , Ambrosio C. 2 , Kostenis E. 3 , Regoli D. 1 , Guerrini R. 4 , Salvatori<br />

S. 4 , Calo’ G. 1<br />

1 Dept Exp and Clin Me<strong>di</strong>cine, Section of Pharmacology, University of Ferrara, Italy;<br />

2 Dept of Pharmacology, ISS, Rome, Italy; 3: Inst for Pharmaceutical Biology, Bonn, Germany;<br />

4: Dept of Pharmaceutical Sciences, University of Ferrara, Italy<br />

78<br />

20. Opposite effects on cell proliferation by wnt1 AND wNT7a proteins in cultured pc12<br />

cells<br />

De Vita Teresa 1 , Spinsanti P. 1 , Caruso A. 1 , Lisi I. 1 , Melchiorri D. 1 , Caricasole A. 2 , Nicoletti F. 1,3<br />

1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”;<br />

2 Sienabiotech S.p.A., Siena; and 3I.N.M. Neuromed, Pozzilli, Italy<br />

Controllo farmacologico dei processi <strong>di</strong> morte e proliferazione cellulare<br />

Poster 21 – 42<br />

21. Role of NO/Ca 2+ /CaM/MAPK signalling pathway in the mitogenic effect of IL-1 in<br />

C6 glioma cells<br />

Sticozzi Clau<strong>di</strong>a, Meini A., Palmi M.<br />

Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena, via Aldo Moro, 2 Siena<br />

22. Neurogenic response induced by fluoxetine chronic treatment in neural progenitor<br />

cells isolated from rat postnatal cerebellum<br />

Zusso Morena, Debetto P., Barbierato M., Guidolin D.*, Giusti P.<br />

Department of Pharmacology and Anestesiology, University of Padova, Italy<br />

*Department of Anatomy and Physiology, University of Padova, Italy<br />

23. Involvement of cannabinoid system in proliferation of cerebellar neural progenitor<br />

cells<br />

Soffia Silvia, Corso M., Barbierato M., Giusti P., Debetto P., Zusso M.<br />

Department of Pharmacology and Anesthesiology “E. Meneghetti”, University of Padova, Italy<br />

24. Effect of oxysterols on cell survival and proliferation pathways in human endothelial<br />

cells<br />

Agnoletto Laura, Poggiani C., Cusinato F., Trevisi L., Luciani S.<br />

Department of Pharmacology and Anaesthesiology, University of Padova<br />

pag_sx.indd 1 30/05/2007 3.50.45


25. Expression of CXCR4 and SDF1/CXCL12 in human normal pituitary and pituitary<br />

adenoma tissues: role in cell proliferation<br />

Florio Tullio, Barbieri F., Bajetto A., Porcile C., Pattarozzi A.,Gatti M., Corsaro A., Thellung S.,<br />

Villa V., Schettini G.<br />

Section of Pharmacology, Department of Oncology, Biology and Genetics, University of<br />

Genova, Italy<br />

26. Dopamine and L-DOPA increase in vitro proliferation of stem cells from the mouse<br />

subventricular zone<br />

Serra Pier Andrea a , Migheli R.,Rocchitta G., Calia G., Dedola S., Manca A. a , L‘Episcopo<br />

F. c , Pluchino S. b , Marchetti B. a,c , Desole M.S. a<br />

a Department of Pharmacology, University of Sassari, 07100 Sassari, Italy<br />

b Department of Neuroscience, S. Raffaele Scientific Institute, Milano,<br />

Italy<br />

c OASI Institute for Research and Care on Mental Retardation and Brain Aging<br />

(IRCCS), Neuropharmacology Section, Troina, Italy<br />

27. Antiproliferative effects of pyrazolo-pyrimi<strong>di</strong>ne -type inhibitors of SRC family<br />

tyrosine kinases derivates on human neuroblastoma cells<br />

Navarra Michele 1 , Celano M. 2 , Schenone S. 3 , Botta M. 4 , Bramanti P. 5 , Russo D. 2<br />

1 Pharmaco-Biological Department, University of Messina, 2 Department of Pharmacobiological<br />

Sciences, University "Magna Græcia" of Catanzaro, 2 Department of Pharmaceutical Sciences,<br />

University of Genova, 4 Department of Pure and Applied Me<strong>di</strong>cinal Chemistry, University of<br />

Siena, 5 IRCCS centro neurolesi “Bonino-Pulejo”<br />

28. Neuron-like cells derived from bone marrow stromal cells: expression and<br />

functioning of GABA B receptors<br />

Cervetto Chiara 1 , Paluzzi P. 1 , Guarnieri S. 1 , Marcoli M. 1 , Castagnola P. 2 , Tonachini L. 2 ,<br />

Mastrogiacomo M. 2 , Monticone M. 2 , Pestarino M. 3 , Can<strong>di</strong>ani S. 3 , Maura G. 1*<br />

1 Dep. Experimental Me<strong>di</strong>cine, 3 Dep. Biology, * Centre of Excellence for Biome<strong>di</strong>cal Research,<br />

University of Genova and 2 Ist Naz Ricerca sul Cancro, Genova, Italy<br />

79<br />

29. Influence of leptin on the early phases of bone formation during mouse skeleton<br />

organogenesis<br />

1 Rivasi Marianna, 1 Benelli A., 2 Ferretti M., 2 Benincasa M., 2 Bertoni L., 2 Cavani F., 2 Palumbo C.<br />

1 Dept. of Biome<strong>di</strong>cal Sciences, Section of Pharmacology; 2 Dept. of Anatomy and Istology,<br />

Section of Human Anatomy; University of Modena and Reggio Emilia, Modena, Italy<br />

30. Proliferation and invasiveness of human smooth muscle TSC2-/- cells. Effect of anti-<br />

EGFR and rapamycin<br />

Di Giulio Anna Maria, Isaia E., Grande V., Lesma E., Gorio A.<br />

Pharmacological Laboratories, Dept. of Me<strong>di</strong>cine, Surgery and Dentistry, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />

<strong>di</strong> Milano<br />

31. Reversion of the phenotype of human TSC2 -/- smooth muscle cells. Novel insights for<br />

TSC and LAM therapy<br />

Lesma Elena, Grande V., Isaia E., Di Giulio A. M., Gorio A.<br />

Pharmacological Laboratories, Dept. of Me<strong>di</strong>cine, Surgery and Dentistry, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />

<strong>di</strong> Milano<br />

32. Expression of Annexin A1 in mouse myoblast <strong>di</strong>fferentiation cell line<br />

Bizzarro Valentina, Festa M., Ercolino S.F., Franceschelli S., Solito E.*, Parente L., Putrella A.<br />

Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy<br />

*Department of Cellular and Molecular Neuroscience, Faculty of Me<strong>di</strong>cine, Imperial College,<br />

London, UK<br />

pag_dx.indd 1 30/05/2007 3.51.35


33. The glucocorticoid-induced leucine zipper (Gilz) inhibits skeletal myogenesis by<br />

counteracting myod activity<br />

Donato Valerio 1 , Velar<strong>di</strong> E. 1 , Bruscoli S. 1 , Bastianelli A. 1 , Donato R. 2 , Riccar<strong>di</strong> C. 1<br />

1 Dept. Clinical and Experimental Me<strong>di</strong>cine, Sect. Pharmacology, and 2 Dept. Experimental<br />

Me<strong>di</strong>cine and Biochemical Sciences, Sect. Anatomy, Perugia University Me<strong>di</strong>cal School,<br />

06122, Perugia, Italy<br />

34. Calixarene glycoconjugates inhibit c6 glioma cell proliferation and migration:<br />

interaction with growth factors<br />

Viola Santa 1 , Consoli Grazia M.L. 2 , Merlo S. 1 , Geraci C. 2 , Sortino M. A. 1<br />

1 Department of Experimental and Clinical Pharmacology, University of Catania and 2 Institute<br />

of Biomolecular Chemistry, CNR, Valverde, Catania<br />

35. Cannabinoids inhibit human colon cancer cell proliferation through CB 2 -receptor and<br />

ceramide pathway activation<br />

Mastroianni Rosanna a , Cianchi F. b , Magnelli L. c , Schiavone N. c , Perna F. b , Capaccioli S. c ,<br />

Manera C. d , Mannaioni P.F., Masini E. a<br />

a Department of Preclinical and Clinical Pharmacology, b Department of Critical Care Me<strong>di</strong>cine<br />

and c Department Pathology and Experimental Oncology, University of Florence, Florence,<br />

Italy; d Department of Pharmaceutical Sciences, University of Pisa, Pisa, Italy<br />

80<br />

36. Role of Lox pathway and endocannabinoid system in antitumor activity of<br />

Cannabi<strong>di</strong>ol, a non-psychoactive cannabinoid<br />

Valenti Marta 2 , Massi P. 1 , Gasperi M. 3 , Meli S. 2 , Maccarrone M. 3 Parolaro D. 2<br />

1 Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via<br />

Vanvitelli 32, Milan, Italy<br />

2 Department of Structural and Functional Biology, Pharmacology Section, Center of<br />

Neuroscience, University of Insubria, Via A. da Giussano 10, Busto Arsizio (VA), Italy<br />

3 Department of Biome<strong>di</strong>cal Sciences, University of Teramo, 64100 Teramo, Italy<br />

37. Effects of the IL-6 receptor superantagonist SANT7 on TGF-B-induced cell<br />

proliferation and MAP kinase phosphorylation in primary cultures of fibrotic human<br />

lung fibroblasts<br />

Gallelli Luca, Falcone D., Renda T., Pelaia G.o, Maselli R., Savino R., De Sarro G.<br />

Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine, University Magna<br />

Graecia of Catanzaro, Italy<br />

38. Effects of simvastatin and betamethasone on hydrogen peroxide induced MAPK<br />

activation, IL-8 production and cell proliferation in primary cultures of human<br />

squamous lung cancer cells<br />

Fratto Donatella 1 , Gallelli L. 1 , Renda T. 1 , Pelaia G. 2 , Maselli R. 2 , De Sarro G. 1<br />

1 Chair of Pharmacology, and 2 Chair of Respiratory Diseases, Department of Experimental and<br />

Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Italy<br />

39. PKC isoenzyme is involved in growth and angiogenesis of prostate cancer<br />

Betti Niccolò 1 , Morbidelli L. 1 , Corti F. 2 , Mochly-Rosen D. 3 , Ziche M. 1<br />

1 Pharmacology section, Dept Molecular Biology, University of Siena. 2 Proteomic section, Dept<br />

Molecular Biology, University of Siena. 3 Molecular pharmacology, School of Me<strong>di</strong>cine,<br />

Stanford University<br />

pag_sx.indd 1 30/05/2007 3.52.27


40. Tumor necrosis factor related apoptosis inducing ligand inhibits angiogenesis<br />

stimulated by human glioblastoma cells<br />

Scuderi Mariagrazia Rita, Albini A. 1 , Lempereur L., Pennisi G. 2 , Bernar<strong>di</strong>ni R., Cantarella G.<br />

Department of Experimental and Clinical Pharmacology; and Department of Chemical<br />

Sciences; University of Catania, 95100 Catania, Italy; Laboratory of Molecular Oncology,<br />

Istituto Tumori, 16100 Genova, Italy<br />

41. Antiangiogenic and antitumour effects of metronomic irinotecan (CPT-11)<br />

Fioravanti Anna 1 , Orlan<strong>di</strong> P. 1 , Falcone A. 2 , Danesi R. 1 , Del Tacca M. 1 , Bocci G. 1<br />

1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />

Pisa, 2 Oncology Unit; General Hospital, Livorno<br />

42. Natural and semisynthetic antraquinones, flavonoids and naphtoquinones effects on<br />

cell cycle in human ovarian cancer<br />

Montopoli M., Moro S.*, Cozza G.*, Zagotto G. *, Frol<strong>di</strong> G., Ragazzi E., Caparrotta L.<br />

Department of Pharmacology and Anaestesiology, University of Padova Largo E. Meneghetti 2,<br />

35131 Padova, Italy. * Department of Pharmaceutical Sciences, University of Padova, Via<br />

Marzolo 5, 35131 Padova, Italy<br />

Farmacologia della trasmissione sinaptica<br />

Poster 43 – 55<br />

43. SNAP-25 Phosphorylation on Serin 187 me<strong>di</strong>ates negative modulation of neuronal<br />

calcium dynamics<br />

Pozzi Davide 1 , Condliffe S. 1 , Grumelli C. 1 , Bozzi J. 2 , Caleo M. 2 , Proux-Gillardeaux V. 3 ,<br />

Takahashi M. 4 , Verderio C. 1 , Matteoli M. 1<br />

1 Department of Me<strong>di</strong>cal Pharmacology and CNR Institute of Neuroscience, Center of<br />

Excellence for Neurodegenerative Diseases, University of Milano, Via Vanvitelli 32, 20129<br />

Milano, Italy. 2 CNR- Institute of Neuroscience via G. Moruzzi 1, 56100 Pisa, Italy. 3 Institut<br />

Jacques Monod UMR7592 Tour 43 2ème étage 2, place Jussieu, F-75251 Paris Cedex 05,<br />

France. 4 Department of Biochemistry, Kitasato University School of Me<strong>di</strong>cine, Kitasato 1-15-1,<br />

Sagamihara-shi, Kanagawa 228-8555, Japan<br />

81<br />

44. Selective regulation of [ 3 H]D-aspartate release from hyppocampal nerve en<strong>di</strong>ngs by<br />

large-conductance Ca 2+ - and voltage-activated K + (BK) channels<br />

Martire Maria 1 , D’Amico M. 1 , Calciano S. 1 , Panza E. 2 , Iannotti F. 2,3 , Barrese V. 2 , Preziosi P. 1 ,<br />

Annunziato L. 2 , Tagliatatela M. 2,3<br />

1 Inst. of Pharmacology, Catholic University of S. Heart, Rome; 2 Division of Pharmacology,<br />

Dept. of Neuroscience, University of Naples Federico II, Naples; 3 Dept. of Health Science,<br />

University of Molise, Campobasso; Italy<br />

45. KCNQ channels regulate depolarization-induced changes in intracellular Ca 2+<br />

concentrations in rat cerebrocortical nerve en<strong>di</strong>ngs<br />

1 Luisi Rosa, 1 Panza E., 1 Secondo A., 2 Martire M., 1 Annunziato L., 1,3 Maurizio Taglialatela M.<br />

1 Div. of Pharmacology, Dept. of Neuroscience, School of Me<strong>di</strong>cine, Univ. “Federico II”, Naples;<br />

2 Insitute of Pharmacology, School of Me<strong>di</strong>cine, Catholic Univ. of Sacred Heart, Rome; 3 Dept.<br />

of Health Sciences, Univ. of Molise, Campobasso, Italy<br />

46. Adult astroglia is competent for Na + /Ca 2+ exchanger-operated exocytotic glutamate<br />

release triggered by mild depolarization<br />

1 Zappettini Simona, 2 Alloisio S., 1 Raiteri L., 1 Paluzzi S., 2 Nobile M., 1 Bonanno G.<br />

1 Department of Experimental Me<strong>di</strong>cine - Pharmacology and Toxicology Section and Center of<br />

Excellence for Biome<strong>di</strong>cal Research, University of Genoa, Italy. 2 Institute of Biophysics,<br />

National Research Council, Genoa, Italy<br />

pag_dx.indd 1 30/05/2007 3.53.40


47. Mechanisms of [ 3 H]glycine release from mouse spinal cord synaptosomes selectively<br />

labelled through glyt2 transporters<br />

Luccini Elisa, Raiteri L.<br />

Department of Experimental Me<strong>di</strong>cine, Pharmacology and Toxicology Section, University of<br />

Genoa<br />

48. Importance of protein kinase C epsilon for the allosteric modulation of GABA evoked<br />

currents in cortical culture at <strong>di</strong>fferent DIV<br />

Garzon Giorgio, Baral<strong>di</strong> M., Puja G.<br />

Dept. of BioMe<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Via G. Campi 287,<br />

41100 Modena, Italy<br />

49. 7 nicotinic receptor present on mouse cortical astrocytes modulates endogenoous<br />

glutamate release<br />

Patti Laura 1 , Raiteri L. 1 , Grilli M. 1 , Robino F. 1 , Zappettini S. 1 , Bonanno G.B. 1,2 , Marchi M. 1,2<br />

1 Section of Pharmacology and Toxicology, Department of Experimental Me<strong>di</strong>cine, University of<br />

Genoa, Italy. 2 Center of Excellence for Biome<strong>di</strong>cal Research, University of Genoa, Italy<br />

50. The agonist of metabotropic glutamate 5 receptors CHPG inverts the effects of DHK<br />

(a blocker of glial glutamate uptake): an in vivo microdyalisis study<br />

Armida Monica, Pintor A., Pèzzola A., Popoli P.<br />

Department of Therapeutic Research and Me<strong>di</strong>cines Evaluation, Istituto Superiore <strong>di</strong> Sanità,<br />

Roma (Italy)<br />

82<br />

51. The metabotropic glutamate 5 (mGlu5Rs) and the adenosine A 2A receptors (A 2A Rs)<br />

oppositely modulate CB1-induced reduction of synaptic transmission in the rat<br />

striatum<br />

Martire Alberto, Tebano M.T., Domenici M.R., Popoli P.<br />

Department of Therapeutic Research and Me<strong>di</strong>cines Evaluation, Istituto Superiore <strong>di</strong> Sanità,<br />

Roma (Italy)<br />

52. Glutamate release induced by activation of GAT-1 transporters sited on glutamate<br />

releasing spinal cord gliosomes and its augmentation in a mouse model of<br />

amyotrophic lateral sclerosis<br />

1 Milanese Marco, Raiteri L., 1 Zappettini S., 2 Usai C., 1 Bonanno G.<br />

1 Department of Experimental Me<strong>di</strong>cine - Pharmacology and Toxicology Section and Center of<br />

Excellence for Biome<strong>di</strong>cal Research, University of Genoa, Italy. 2 Institute of Biophysics,<br />

National Research Council, Genoa, Italy<br />

53. Thyroid hormones modulate glutamatergic neurotransmission in hippocampus<br />

Puja Giulia, Losi G., Garzon G., Baral<strong>di</strong> M.<br />

Dept. of BioMe<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Via G. Campi 287,<br />

41100 Modena, Italy<br />

54. Role of ionotropic glutamatergic receptors in the regulation of hippocampal<br />

norepinephrine ouput in vivo<br />

Matzeu Alessandra, Dazzi L., Biggio G.<br />

Department of Experimental Biology, Neuroscience section, University of Cagliari, Cagliari,<br />

Italy<br />

55. Alterations of glutamatergic transmission in a murine model of multiple sclerosis:<br />

preliminary results<br />

Pepicelli Olimpia a , Marte A. a , Uccelli A. c , Mancar<strong>di</strong> L. c , Raiteri M. a,b , Fedele E. a,b<br />

a Dept. of Experimental Me<strong>di</strong>cine, Pharmacology and Toxicology Section, University of Genoa;<br />

b Centre of Excellence for Biome<strong>di</strong>cal Research, University of Genoa; c Dept. of Neurosciences,<br />

Ophthalmology and Genetics, University of Genoa, Italy<br />

pag_sx.indd 1 30/05/2007 3.54.37


Farmacologia car<strong>di</strong>ovascolare<br />

Poster 56 – 70<br />

56. Mo<strong>di</strong>fication of pressure and placental protein expression in pregnant spontaneously<br />

hypertensive rats (SHR)<br />

1 Bianco Giuseppe, Iacono A., Esposito E., Mattace Raso G., 1 Autore G., Meli R.<br />

Department of Experimental Pharmacology, University of Naples “Federico II”, Naples,<br />

1 Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy<br />

57. Increased p22phox expression and reduced SOD activity are involved in early<br />

impairment of insulin-induced vaso<strong>di</strong>lation on resistance vessels of spontaneously<br />

hypertensive rats (SHR)<br />

Gagliar<strong>di</strong> Sara, Potenza M.A., Marasciulo F.L., Montagnani M.<br />

Department of Pharmacology and Human Physiology - Me<strong>di</strong>cal School - University of Bari,<br />

70124 Bari, Italy<br />

58. Vaso<strong>di</strong>lator activity of hydrogen sulfide (H 2 S) in human isolated mesenteric arteries<br />

Materazzi Serena 1 , Patacchini R. 2 , Nassini R. 1 , Zagli G. 1 , Giannelli M. 1 , Bechi P. 1 , Nicoletti P. 1 ,<br />

Geppetti P. 1, Harrison S. 1<br />

1 Department of Critical Care Me<strong>di</strong>cine & Surgery, University of Florence, Florence, Italy; and<br />

2 Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy; Florence, Italy<br />

59. The vasorelaxant and anti-inflammatory action of raloxifene in rat aorta is partially<br />

me<strong>di</strong>ated by estrogen receptor alpha<br />

Pelosi Valeria 1,2 , Sancito P. 1,2 , Bolego C. 1 , Pinna C. 1 , Corsini A. 1 , Gaion R.M. 2 , Cignarella A. 1,2<br />

1 Department of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan;<br />

2 Department of Pharmacology and Anaesthesiology, University of Padova, Largo Meneghetti<br />

2, 35131 Padova, Italy<br />

83<br />

60. Inhibitors of cystathionine --lyase (CSE), propargylglycine and -cyanoalanine,<br />

modulate arterial vasorelaxation in rat aorta<br />

Vellecco Valentina, Di Lorenzo A., De Gruttola L., Brancaleone V., Roviezzo F., Bucci M., Cirino<br />

G.<br />

Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples<br />

“Federico II”<br />

61. Direct effects of ticlopi<strong>di</strong>ne and clopidogrel on resistance vessel in vitro<br />

Frol<strong>di</strong> Guglielmina, Montopoli M., Dorigo P., Caparrotta L.<br />

Department of Pharmacology and Anesthesiology -Pharmacology Division- Largo E.<br />

Meneghetti 2, University of Padova (Italy)<br />

62. Asymmetric <strong>di</strong>methylarginine (ADMA) induces vascular endothelium impairment and<br />

aggravates myocar<strong>di</strong>al ischemia-reperfusion injury in rats<br />

Bonomo Sara M. a , De Gennaro Colonna V. a , Manfre<strong>di</strong> B. a , Ferrario P. a ,.Bianchi M. a , Berti M. b ,<br />

Guazzi M. c , Berti F. a , Rossoni G. a<br />

a Department of Pharmacology, Chemoterapy and Me<strong>di</strong>cal Toxicology, University of Milano, Via<br />

Vanvitelli 32, Italy; b Institute of Car<strong>di</strong>ology, Monzino Car<strong>di</strong>ology Center, IRCCS, Milan, Italy;<br />

c Car<strong>di</strong>opulmonary Laboratory, Car<strong>di</strong>ology Division, University of Milano, San Paolo Hospital,<br />

Milano, Italy<br />

pag_dx.indd 1 30/05/2007 3.55.30


63. Anti-inflammatory and car<strong>di</strong>oprotective activities of synthetic HDL containing the<br />

37PA peptide<br />

Gomaraschi Monica*, Remaley A. # , Rossoni G. § , Franceschini G.*, Calabresi L.*<br />

*Center Enrica Grossi Paoletti, Department of Pharmacological Sciences, University of Milano,<br />

Italy, # Molecular Disease Section, National Heart, Lung, and Blood Institute, National<br />

Institutes of Health, Bethesda, MD, USA and § Department of Pharmacological Sciences,<br />

University of Milano, Italy<br />

64. Human pharmacology of naproxen so<strong>di</strong>um<br />

Capone Marta L., § † , Tacconelli S.,§ † Sciulli M.G. §† , Anzellotti P. §† , Di Francesco L. §† , Merciaro<br />

G. ‡ , Di Gregorio P. ‡ , Patrignani P. §†<br />

§ Department of Me<strong>di</strong>cine and Aging, School of Me<strong>di</strong>cine, “G.d’Annunzio” University; † “G.<br />

d’Annunzio” University Foundation, Ce.S.I.; and ‡ SS Annunziata Hospital, Chieti, Italy<br />

65. Doxorubicin car<strong>di</strong>otoxicity and apoptosis: variation of exposure times to the same<br />

cumulative dose<br />

Vitelli Maria Redenta, Piegari E., Rodolico G., Leone L., Marino L., Oliva P., Rossi F., Berrino L.<br />

Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />

Surgery, Second University of Naples – Via Costantinopoli, 16 – 80138 Napoli<br />

84<br />

66. Apoptotic cell death in doxorubicin-induced car<strong>di</strong>omyopathy: role of peroxynitrite<br />

and LOX-1 receptor modulation<br />

Sculco Francesca 1 , Muscoli Ca. 1,2 , Palma E. 1 , Sacco I. 1 , Visalli V. 1 , Costa N. 1 , Rotiroti D. 1 ,<br />

Romeo F. 3 , Mollace V 1,2<br />

1 Faculty of Pharmacy, University “Magna Graecia” of Catanzaro, Italy; 2 San Raffaele Pisana<br />

IRCCS, Rome, Italy; 3 Chair of Car<strong>di</strong>ology, University of Rome “Tor Vergata”, Rome, Italy;<br />

4 Faculty of Pharmacy, University of Messina, Italy<br />

67. Ubiquitin-proteasome system contributes to the inflammatory injury of Experimental<br />

Acute <strong>di</strong>abetic myocar<strong>di</strong>al infarct<br />

D’Amico Michele 1,2 , Di Filippo C. 1,2 , Martella R. 3 , Rossi F. 1,2 ,<br />

1 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology L. Donatelli, 2 ”Excellence<br />

Centre for Car<strong>di</strong>ovascular Disease”, and 3 Department of Geriatrics and Metabolic Diseases,<br />

2nd University of Naples, Italy<br />

68. Effects of oral essential amino acid supplementation in cachectic insuline resistance<br />

patients with chronic heart failure<br />

Boschi Federica * , Verri M. * , Dossena M. * , Opasich C.°, Aquilani R.^, Gualco A. ° , Pastoris O * .<br />

* Department of Physiological & Pharmacological Sciences, University of Pavia, Pavia, Italy;<br />

^IRCCS “S. Maugeri” Foundation, Montescano, Italy; °IRCCS “S. Maugeri” Foundation, Pavia<br />

69. Gender-<strong>di</strong>fferences in no and edhf modulation of vascular reactivity in rabbit<br />

mesenteric artery<br />

Fabi Fulvia, Coletta T., Lorenzini P., Del Basso Orsini P.<br />

Department of Drug Research and Evaluation, Istituto Superiore <strong>di</strong> Sanità, Roma, Italy<br />

70. Gender <strong>di</strong>fferences in nitric oxide production by inducible nitric oxide synthase in<br />

cytokine-stimulated rabbit carotid arteries<br />

Del Basso Orsini Paola, Calciano S., Fabi F.<br />

Department of Drug Research and Evaluation, Istituto Superiore <strong>di</strong> Sanità, Roma, Italy<br />

pag_sx.indd 1 30/05/2007 3.56.26


Farmacologia del sistema nervoso<br />

Poster 71 – 98<br />

71. Time-dependent and sequential modulation of signaling cascades, CREB activation<br />

and BDNF expression induced by antidepressants<br />

Tar<strong>di</strong>to Daniela 1 , Tiraboschi E. 1 , Barbiero V. S 1 , Moraschi S. 2 , Cattaneo A. 2 , Gennarelli M. 2 ,<br />

Racagni G. 1 , Popoli M. 1<br />

1 Center of Neuropharmacology, Dept of Pharmacological Sciences and Center of Excelence on<br />

Neurodegenerative Diseases, University of Milan, Italy. 2 Genetics Unit, I.R.C.C.S. “S. Giovanni<br />

<strong>di</strong> Dio”, Fatebenefratelli, Brescia, and Division of Biology and Genetics, Department of<br />

Biome<strong>di</strong>cal Sciences and Biotechnologies, University of Brescia, Brescia, Italy<br />

72. Chronic antidepressant treatments induces specific changes in BDNF expression and<br />

subcellular localization<br />

Maj Paola F. 1 , Calabrese F. 1 , Molteni R. 1 , Cattaneo A. 3 , Gennarelli M. 2,3 , Racagni G. 1 , Riva M.<br />

A. 1<br />

1 Center of Neuropharmacology, Pharmacol. Sciences Dept., University of Milan, Via Balzaretti<br />

9, 20133 Milan, Italy. 2 I.R.C.C.S. San Giovanni <strong>di</strong> Dio-Fatebenefratelli, Brescia, Italy. 3 Biol.<br />

and Gen. Div., Dept. Biome<strong>di</strong>cals and Biotechnology Sciences, University of Brescia<br />

73. Human astrocytes can be induced by imipramine to <strong>di</strong>fferentiate into cells with<br />

neuronal phenotype<br />

1 Cabras Stefano, 1 Reali C., 1 Scorciapino L., 1 Saba F., 1 Sirigu R., 2 Biggio G., 1 Sogos V.<br />

1 Department of Cytomorphology, University of Cagliari<br />

2 Department of Experimental Biology “Bernardo Loddo”, University of Cagliari<br />

74. Vagus nerve stimulation like antidepressant drugs enhances norepinephrine release<br />

and BDNF gene expression in the rat brain<br />

Gorini Giorgio 1,4 , Biggio F. 1 , Caria S. 1 , Follesa P. 1,2 , Marrosu F. 3 , Dazzi L. 1,2 , and Biggio G. 1,2<br />

University of Cagliari, Dept. of Experimental Biology, Section of Neuroscience 1 , Cntr. of<br />

Excellence for the Neurobiology of Dependence 2 , Dept. of Neurological and Car<strong>di</strong>ovascular<br />

Sciences 3 , 09123 Cagliari, Italy; University of Sassari, Dept. of Pharmacology, Gynecology<br />

and Obstetrics, Section of Pharmacology 4 , 07100 Sassari, Italy<br />

85<br />

75. Escitalopram alters BDNF, CREB and CaRF gene expression in <strong>di</strong>screte rat brain<br />

areas<br />

Benatti Cristina 1 , Alboni S. 1 , Capone G. 1 , Corsini D. 1 , Caggia F. 1 , Tascedda F. 1 , Blom Joan<br />

M.C. 2 , Brunello N. 1<br />

1 Department of Biome<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Modena, Italy;<br />

2 Department of Pe<strong>di</strong>atrics, University of Modena and Reggio Emilia, Modena, Italy<br />

76. Acetyl salicylic acid increases the response of escitalopram in a rat model of<br />

depression<br />

Alboni Silvia 1 , Benatti C. 1 , Capone G. 1 , Caggia F. 1 , Corsini D. 1 , Tascedda F. 1 , Mendlewicz J. 2 ,<br />

Brunello N. 1<br />

1 Department of Biome<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Modena, Italy;<br />

2 Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium<br />

77. Synaptoproteomics of an animal model of depression combining genetic<br />

vulnerability and early-life stress<br />

Mallei Alessandra a , Tiraboschi E. a , Giambelli R. a , El Khoury A. b , Mathè A.A. b , Racagni G. a ,<br />

Popoli M. a<br />

a Center of Neuropharmacology-Department of Pharmacological Sciences, University of Milano<br />

(Italy). b NEUROTEC Department, Division of Psychiatry, Karolinska Institutet, Stockholm,<br />

(Sweden)<br />

pag_dx.indd 1 30/05/2007 3.57.25


78. Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the<br />

treatment of depression: a new strategy to shorten the latency of antidepressant<br />

me<strong>di</strong>cation?<br />

Matrisciano Francesco a,b , Panaccione I. a , Zusso M. d , Giusti P. d , Tatarelli R. b , Caruso A. a ,<br />

Iacovelli L. a , Scaccianoce S. a , Mathé A.A. c , Gruber S.H. c , Melchiorri D. a , Girar<strong>di</strong> P. b ,<br />

F. Nicoletti a,e<br />

a Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />

Piazzale Aldo Moro, 5, 00185 Rome, Italy. b Department of Psychiatry and Psychological<br />

Me<strong>di</strong>cine, Sant’Andrea Hospital, University of Rome “La Sapienza”; c Karolinska Institute,<br />

Department of Clinical Neuroscience - Psychiatry, Karolinska University Hospital Hud<strong>di</strong>nge,<br />

Stockholm, Sweden; d Department of Pharmacology and Anesthesiology, University of Padova,<br />

Italy; e I.N.M. Neuromed, Pozzilli, Italy<br />

79. Modulation of pre-synaptic and post-synaptic proteins after prolonged treatment<br />

with antipsychotic drugs<br />

Frasca Angelisa 1 , Fumagalli F. 1 , Racagni G. 1 , Riva M.A. 1<br />

1 Center of Neuropharmacology, Department of Pharmacological Sciences University of Milan,<br />

Via Balzaretti 9, 20133 Milan (Italy)<br />

86<br />

80. Effect of typical and atypical antipsychotics on in vivo dopamine transmission in<br />

<strong>di</strong>fferent brain areas<br />

Ullu Laura M., Valentini V., Tanda G., De Luca M.A., Di Chiara G.<br />

Department of Toxicology, Centre of Excellence “Neurobiology of Ad<strong>di</strong>ction", University of<br />

Cagliari, Italy<br />

81. Agonist activity of N-Desmethylclozapine, a major clozapine metabolite, at delta<br />

opioid receptors<br />

Olianas Maria C., Dedoni S., Garau L., Onali P.L.<br />

Section of Biochemical Pharmacology, Department of Neuroscience, University of Cagliari,<br />

Cagliari, Italy<br />

82. Haloperidol both prevents and reverses quinpirole-induced non regulatory water<br />

intake, a putative animal model of psychogenic poly<strong>di</strong>psia<br />

Amato Davide 1 , Stasi Maria Antonietta 2 , Borsini Franco 2 , Nencini Paolo 1<br />

1 Department of Human Phisiology and Pharmachology, University of Rome Sapienza,<br />

2 Research and Development Division, sigma-tau Industrie Farmaceutiche Riunite SpA,<br />

Pomezia<br />

83. Different role of NMDA receptors in the rostral and caudal part of thalamic reticular<br />

nucleus in a rat model of absence epilepsy, the WAG/Rij rat<br />

Citraro Rita 1 , Marra R 2 ., Scicchitano F 1 ., Russo E 1 ., Ferreri Ibbadu G 1 ., De Sarro<br />

G 1 .<br />

1 Section of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine and Surgery, University of Catanzaro, Italy, 2 ISBAF CNR, Department of<br />

Pharmacology, Faculty of Pharmacy, University of Catanzaro, Catanzaro, Italy<br />

84. Effects of adenosine receptor agonists and antagonists administration on spikewave<br />

<strong>di</strong>scharge in a genetic model of generalized absence epilepsy<br />

Citraro Rita 1 , Ferreri G. 1 , Russo E. 1 , D’Auro M. 2 , Ciccarelli R. 2 , De Sarro G. 1<br />

1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine and Surgery, University of Catanzaro, 2 Chair of Pharmacology, Faculty of Me<strong>di</strong>cine<br />

and Surgery, University of Chieti, Italy<br />

pag_sx.indd 1 30/05/2007 3.58.24


85. Effects of the focal administration of MGLU2/3 receptor ligands in selected brain<br />

areas of WAG/RIJ rat, a genetic animal model of absence of epilepsy<br />

1 De Sarro Giovambattista, 1 Citraro R., 2 Ngomba R., 1 Russo E., 2 Battaglia G.,<br />

2,3 Nicoletti F.<br />

1 Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery,<br />

University of Catanzaro, Catanzaro, Italy,<br />

2 I.N.M. Neuromed, 86077 Pozzilli, Italy,<br />

3 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy<br />

86. Homocysteine induced an increase of absence seizures in the electrocographic<br />

pattern of WAG/Rij rat<br />

Ferreri Ibbadu Guido 1 , Citraro R. 1 , Marra R. 2 , Siniscalchi A. 1,3 , Russo E. 1 , De<br />

Sarro G. 1<br />

1 Section of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine and Surgery, University of Catanzaro, Italy, 2 ISBAF CNR, Department of<br />

Pharmacology, Faculty of Pharmacy, University of Catanzaro, Catanzaro, 3 Depatment of<br />

Neuroscience, Annunziata Hospital, Cosenza, Italy<br />

87. Effects of non-competitive AMPA receptor antagonists injected into some brain areas<br />

of WAG/Rij rats, an animal model of generalized absence epilepsy<br />

1 Ferreri I. Guido, 2 Palma E., 2 Marra R., 1 Citraro R., 1 Russo E., 1 Curinga C., 3 Gitto R., 3 Chimirri<br />

A, 1 De Sarro G.<br />

1 Section of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine and Surgery, University of Catanzaro. 2 National council of research institute of<br />

neurological science, Catanzaro. 3 Department of Me<strong>di</strong>cinal Chemistry, Faculty of Pharmacy,<br />

University of Messina, Italy<br />

88. Selective activation of metabotropic glutamate receptors subtype 4 enhances<br />

spontaneous and evoked absence seizures<br />

Santolini Ines 1,4 , Ngomba R. 1 , Biagioni F. 1 , Citraro R. 2 , Radura A. 3 , Battaglia G. 1 , Bruno V. 1,4 ,<br />

Ferraguti F. 5 , Van Luijtelaar G. 3 , De Sarro G. 2 , Nicoletti F. 1,4<br />

1 I.N.M. Neuromed, Pozzilli, Italy; 2 Dept. of Exp. & Clin. Med., Univ. of Catanzaro, Italy; 3 Dept.<br />

of Biol. Psychol., Univ. of Nijmegen, The Netherlands; 4 Dept. of Hum. Physiol. & Pharm., Univ.<br />

“La Sapienza”, Rome, Italy; 5 Dept. of Pharm., Univ. of Innsbruck, Austria<br />

87<br />

89. Prenatal ethanol exposure effects on MAP-kinases pathway in a genetic model of<br />

absence epilepsy: the WAG/RIJ rat<br />

1 Arbitrio Mariamena, 3 Costa N., 1 Vecchio I., 1 Marra R., 1 Iannone M., 1 Strongoli M.C., 2 Cuda G.,<br />

2 Casadonte R., 2 De Sarro G., 1,3 Rotiroti D<br />

1 National Council of Research Institute of Neurological Science-Catanzaro. 2 Department of<br />

Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery-Catanzaro. 3 Chair of<br />

Pharmacology, Faculty of Pharmacy-Catanzaro<br />

90. Topiramate dose-dependently mo<strong>di</strong>fies slow inhibitory post synaptic potentials<br />

evoked in rat olfactory cortical neurones in in vitro<br />

1 Russo Emilio, 1 De Sarro G., 2 Constanti A.<br />

1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine and Surgery, University of Catanzaro, Catanzaro, Italy; 2 Pharmacology Department,<br />

School of Pharmacy, University of London, London, UK<br />

91. Zonisamide induces a slow dose-dependent hyperpolarization in rat olfactory<br />

cortical neurones in vitro<br />

1 Russo Emilio, 1 Scarfone S., 1 De Sarro G.<br />

1 Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery,<br />

University of Catanzaro, Catanzaro, Italy<br />

pag_dx.indd 1 30/05/2007 4.02.38


92. Effects of nitric oxide influence on experimentally-induced hyperexcitability of the<br />

hippocampus: in vivo and in vitro comparative electrophysiological study in the rat<br />

Rizzo Valerio 1 , Ferraro G. 1 , Sardo P. 1 , Carletti F. 1 , D’Agostino S. 1 , La Grutta V. 1 , Cannizzaro<br />

G. 2<br />

1 Dip. Me<strong>di</strong>cina Sperimentale, Sez. Fisiologia umana, Università <strong>di</strong> Palermo, Italy. 2 Dip. Scienze<br />

Farmacologiche, Università <strong>di</strong> Palermo, Italy<br />

93. Changes in neuroactive steroids levels, GABA A receptor plasticity and sensitivity to<br />

anxiolytic drugs induced by neonatal exposure to estrogen<br />

Calza Arianna, Sogliano C., Marra C.,Paganelli P.,Santoru F., Angioni M.M.,Biggio G.,Concas A.<br />

Department of Experimental Biology and Centre of Excellence for the “Neurobiology of Drug<br />

Dependence”, University of Cagliari, Italy<br />

94. Subchronic administration of statins reduces plasma and brain content of<br />

neuroactive steroids<br />

1 Dore Riccardo, 4 Pisu M.G., 2 Muntoni S., 134 Serra M., 134 Biggio G.<br />

1 Department of Experimental Biology; 2 Department of Toxicology, Unit of Oncology and<br />

Molecular Pathology; 3 Center of Excellence for the Neurobiology of Dependence; 4 CNR<br />

Institute of Neuroscience, Section of Cagliari, University of Cagliari<br />

88<br />

95. Flumazenil-sensitive dose-related physical dependence in planarians produced by<br />

two benzo<strong>di</strong>azepine and one non-benzo<strong>di</strong>azepine benzo<strong>di</strong>azepine receptor agonists<br />

Cavallo Federica b , Raffa R. B. a , Capasso A. b<br />

a Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia,<br />

PA, USA, b Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy<br />

96. GABAergic drugs become neurotoxic in cortical neurons pre-esposed to<br />

brain_derived neurotrophic factor<br />

Molinaro Gemma 1 , Battaglia G. 1 , Riozzi B. 1 , Storto M. 1 , Fucile S. 1,2 , Eusebi F. 1,2 , Nicoletti F. 1,2<br />

Bruno V. 1,2<br />

1 Istituto Neurologico Me<strong>di</strong>terraneo Neuromed, Pozzilli, Italy; 2 Department of Human<br />

Physiology and Pharmacology, University of Rome “La Sapienza”, Rome, Italy<br />

97. Expression patterns of promoters for NPY Y1 and Y5 receptors in Y5RITTA and<br />

Y1RVENUS bac transgenic mice<br />

Longo Angela, Oberto A., Acquadro E., Busb T., Sprengel R., Eva C.<br />

Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale; Sezione <strong>di</strong> Farmacologia,<br />

Università <strong>degli</strong> stu<strong>di</strong> <strong>di</strong> <strong>Torino</strong>. Department of Molecular Neurobiology Max Planck Institute<br />

for Me<strong>di</strong>cal Research, 69120, Heidelberg, Germany<br />

98. Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by<br />

fluctuations in the brain content of neuroactive steroids during ethanol withdrawal<br />

in mice<br />

Bertocchi Ilaria, Eva C., Mele P., Collura D., Pisu M.P., Serra M., Biggio G.<br />

Dip.Anatomia, Farmacologia e Med Leg, Sez. Farmacologia, Università <strong>di</strong> <strong>Torino</strong>, Italy; Dip<br />

Biol Sperimentale, Sez Neuroscienze, Università <strong>di</strong> Cagliari, Italy; Centro Ecc. Neurobiol.<br />

Dipendenza, Università <strong>di</strong> Cagliari, Italy; C.N.R. Ist. Neurosci, Neuropsicofarmac., Cagliari<br />

Farmacologia dei processi degenerativi<br />

Poster 99 – 124<br />

99. Sulforaphane inhibits 6-hydroxydopamine-induced apoptosis by upregulation of<br />

MEK/ERK and PI3K/AKT in human neuronal cells<br />

Tarozzi Andrea 1 , Morroni F. 1 , Merlicco A. 1 , Angeloni C. 2 , Hrelia S. 2 , Cantelli-Forti G. 1 , Hrelia P. 1<br />

1 Department of Pharmacology, 2 Department of Biochemistry "G. Moruzzi", Alma Mater<br />

<strong>Stu<strong>di</strong></strong>orum - University of Bologna, via Irnerio 48, 40126 Bologna<br />

pag_sx.indd 1 30/05/2007 4.05.37


100. Characterization of the antiparkinsonian effects of the new adenosine A 2A receptor<br />

antagonist ST1535: acute and subchronic stu<strong>di</strong>es in rats<br />

Tronci Elisabetta (1) , Simola N. (1) , Borsini F. (4) , Schintu N. (1) , Frau L. (1) , Carminati P. (4) , Morelli<br />

M. (1,2,3)<br />

(1) Department of Toxicology, (2) Centre of Excellence for Neurobiology of Dependence, (3) CNR<br />

Institute of Neuroscience, University of Cagliari, Italy, (4) Sigma-Tau Industrie Farmaceutiche<br />

Riunite S.p.A., Pomezia (Rome), Italy<br />

101. Evaluation of the neuroprotective effect of THE A 2A receptor antagonist SCH58261<br />

on the MPTP mouse model of Parkinson’s <strong>di</strong>sease<br />

Schintu Nicoletta, Carta A.R., Morelli M.<br />

Department of Toxicology, University of Cagliari, Italy<br />

102. Mitochondrial factors involved in Parkinson's <strong>di</strong>sease by MPTP toxycity in Macaca<br />

Fascicularis and drug effect<br />

Brera Francesca, Gorini A., Villa R.F.<br />

Dipartimento <strong>di</strong> Scienze Fisiologiche-Farmacologiche Cellulari-Molecolari Sezione <strong>di</strong><br />

Farmacologia e Biotecnologie Farmacologiche Piazza Botta, 11 - 27100 Pavia, Università <strong>degli</strong><br />

<strong>Stu<strong>di</strong></strong> <strong>di</strong> Pavia<br />

103. CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity<br />

Sgadò Paola, Viaggi C., Vaglini F., Par<strong>di</strong>ni C., Caramelli A., Corsini G.U.<br />

Department of Neuroscience, Section of Pharmacology, University of Pisa and Center of<br />

Excellence ‘AMBISEN’ for the study of Environmental Toxins and CNS Diseases, Pisa, Italy<br />

104. Behavioural characterization of engrailed mutant mice as model of Parkinson’s<br />

<strong>di</strong>sease<br />

Pontis Silvia 1 , Pinna A. 2 , Sgadò P. 3 , Corsini G.U. 3 , Morelli M. 1,2<br />

1 Department of Toxicology, University of Cagliari, Italy. 2 CNR Institute for Neuroscience,<br />

Cagliari, Italy. 3 Department of Neuroscience, Pisa, Italy<br />

89<br />

105. Low and high dyskinetic treatments induce <strong>di</strong>fferent motor responses and mRNA<br />

changes in Caudate-Putamen in the 6-OHDA rat model of Parkinson’ s <strong>di</strong>sease<br />

Frau Lucia 1 , Carta A. R. 1 , Pinna A. 2 , Pontis S. 1 , Morelli M. 1,2 .<br />

1 Department of Toxicology, University of Cagliari. 2 CNR, Institute of Neuroscience, Cagliari<br />

106. Blockade of pallidal adenosine A 2A receptors potentiates contralateral rotational<br />

behavior induced by L-DOPA and dopaminergic agonists in hemiparkinsonian rats<br />

Simola Nicola a , Fenu S. a , Baral<strong>di</strong> P.G. b , Tabrizi M. A. b , Morelli M. a<br />

a Department of Toxicology and Centre of Excellence for Neurobiology of Dependence,<br />

University of Cagliari, Cagliari, Italy; b Department of Pharmaceutical Sciences, University of<br />

Ferrara, Ferrara, Italy<br />

107. Analysys of the MPP + uptake in mesencephalic cell cultures from CYP 2E1 Knock-out<br />

mice<br />

Caramelli Andrea, Par<strong>di</strong>ni C., Viaggi C., Vaglini F., Sgadò P., Corsini G.U.<br />

Dip. <strong>di</strong> Neuroscienze Sez. Farmacol. Università <strong>di</strong> Pisa<br />

108. Effects of <strong>di</strong>rect and in<strong>di</strong>rect cannabinoid receptor agonists on levodopa-induced<br />

dyskinesias ina rat model of Parkinson's <strong>di</strong>sease<br />

Morgese Maria Grazia 1,3 , Cassano T. 1 , Trabace L. 1 , Cuomo V. 2 , Giuffrida A. 3<br />

1 Department of Biome<strong>di</strong>cal Sciences, University of Foggia, Italy;<br />

2 Department of<br />

Pharmacology and General Physiology, University of Rome, ‘La Sapienza’, Italy; 3 Department<br />

of Pharmacology, University of Texas Health Science Center at San Antonio, Texas, U.S.A<br />

pag_dx.indd 1 30/05/2007 4.09.03


109. The nitric oxide-leleasing derivative of furbiprofen HCT1026 decreases vulnerability<br />

of nigrostriatal dopaminergic neurons to MPTP via a switch of glia proinflammatory<br />

phenotype: implications for treatment of Parkinson's <strong>di</strong>sease<br />

L’Episcopo Francesca 1 , Testa N. 1 , Caniglia S. 1 , Tirolo C. 1 , Giaquinta G. 1 , Arcieri P. 1 , Serra<br />

P.A. 2 , Bazzu G. 2 , Morale M. C. 1 , Impagnatiello F. 3 , Marchetti B. 1,2<br />

1 Neuropharmacology, OASI Institute Researc and Care (IRCCS) Troina (EN), Italy and<br />

2 Department of Pharmacology, University of Sassari, Me<strong>di</strong>cal School, Sassari, Italy, and<br />

3 Nicox Research Institute, Bresso, Milano, Italy<br />

110. Neuroinflammatory response in the acute MPTP rodent model of Parkinson's<br />

<strong>di</strong>sease: time-dependent correlation with histopathological, neurochemical and<br />

behavioral response to nigrostriatal injury and repair<br />

L’Episcopo Francesca 1 , Salani G. 2 , Serra P.A. 3 , Caniglia S. 1 , Tirolo C. 1 ,Giaquinta G. 1 , Testa<br />

N. 1 , Rocchitta G. 3 , Calia G. 3 , Manca A. 3 , Morale M.C. 1 , Pluchino S. 2 , Martino G. 3 , Marchetti<br />

B. 1,2<br />

1 Neuropharmacology, OASI Institute for Research and Care (IRCCS) Troina (EN), Italy<br />

2 Neuroimmunology Unit, Department of Neurology and Physiology, San Raffaele Scientific<br />

Institute, Milano, and 3 Dept. Pharmacology, University of Sassari Me<strong>di</strong>cal School, Sassari,<br />

Italy<br />

90<br />

111. S100B protein promoted tau protein hyperphosphorilation through DKK-1 protein<br />

up-regulation and relative WNT pathway <strong>di</strong>sruption in cultured human neurons<br />

Esposito Giuseppe 1 , Scuderi C. 1, 4 , De Filippis D. 2 , Iuvone T. 2 , Savani C. 1, 5 , Lu Jie 3 , Sheen<br />

Volney 3 , Steardo L. 1<br />

1 Department of Human Physiology and Pharmacology “Vittorio Erspamer”, University of Rome<br />

“La Sapienza” - 2 Department of Experimental Pharmacology, University of Naples Federico<br />

II.<br />

3 Department of Neurology, Beth Israel Deaconess Me<strong>di</strong>cal Center, Harvard Me<strong>di</strong>cal School,<br />

Boston<br />

4 Department of Pharmacological Sciences, University of Palermo. 5 Department of Human<br />

Physiology and Pharmacology, University of Bari<br />

112. Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor Grb2 and<br />

Modulate ERK1,2 Signaling<br />

Clau<strong>di</strong>o Russo 5 , Nizzari M., Venezia V. 1 , Repetto E. 1 , Corsi V. 2 , Magrassi R. 2 , Gagliani M.C. 3 ,<br />

Florio T. 1 , Schettini G. 1 , Tacchetti C. 3 , Russo T. 4 , Diaspro A. 2<br />

1 Dip. Oncologia, Biologia e Genetica, Università <strong>di</strong> Genova, 2 Dip. Fisica, Università <strong>di</strong> Genova,<br />

3 Dip.Me<strong>di</strong>cina Sperimentale, Università <strong>di</strong> Genova, 4 Dip.Biochimica, Università <strong>di</strong> Napoli<br />

Federico II, 5 Dip. Scienze per la Salute, Università del Molise<br />

113. Nitric oxyde and dopaminergic system: neurochemical interactions in -amyloid<br />

injected rats<br />

Schiavone Stefania (a) , Lanni C. (b) , Cuomo V. (c) , Trabace L. (a) , Govoni S. (b)<br />

(a) Dept. Biome<strong>di</strong>cal Sciences, University of Foggia, Foggia, Italy; (b) Dept. of Experimental<br />

and Applied Pharmacology, University of Pavia, Pavia, Italy; (c) Dept. of Human Physiology<br />

and Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy<br />

114. Alterations of tau protein and effect of lithium salts treatment on TgCRND8 mice<br />

Rosi Maria Cristina, Grossi C., Fiorentini A., Luccarini I., Casamenti F.<br />

Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy<br />

pag_sx.indd 1 30/05/2007 4.18.41


115. Long-term treatment with CHF5074, a novel gamma-secretase modulator, markedly<br />

reduces brain beta-amyloid in a transgenic mouse model of Alzheimer's <strong>di</strong>sease<br />

Imbimbo Bruno P. 1 , Del Giu<strong>di</strong>ce E. 2 , Miccichè F. 2 , Colavito D. 2 , D'Arrigo A. 2 , Dalle Carbonare<br />

M. 2 , Villetti G. 1 , Facchinetti F. 1 , Volta R. 1 , Pietrini V., 3 Baroc M. F. 3 , Leon A. 2<br />

1 Research & Development, Chiesi Farmaceutici, Via Palermo 26/A, 43100 Parma; 2 Research &<br />

Innovation, Via Svizzera 16, 35127 Padua; 3 Department of Neurosciences, Neurology Section,<br />

University of Parma, 43100 Parma<br />

116. Angiogenesis in neurodegenerative processes: loss of regulatory A function<br />

contributes to endothelial degeneration<br />

Donnini Sandra, Cantara S., Giachetti A., Ziche M.<br />

Pharmacology Section, Dept. Molecular Biology, University of Siena, Italy<br />

117. The BH4 domain of Bcl-xl counteracts beta amyloid peptide toxicity on capillary<br />

endothelium<br />

Solito Raffaella, Donnini S., Cantara S., Giochetti A., Ziche M.<br />

Section of Pharmacology, Department of Molecular Biology, University of Siena<br />

118. Mitochondrial dysfunctions in a transgenic murine model of Alzheimer's <strong>di</strong>sease<br />

1 Cassano Tommaso, 2 Servid<strong>di</strong>o G., 2 Bellanti F., 2 Tamborra R., 1 Macheda T., 1 Morgese M.G.,<br />

1 Trabace L., 3 Oddo S., 3 LaFerla F.M., 4 Cuomo V., 2 Vendemiale G.<br />

1 Dept. of Biochemical Sciences Univ. of Foggia, Italy; 2 Dept. of Me<strong>di</strong>cal and Occupational<br />

Sciences, Univ. of Foggia, Italy; 3 Dept. of Neurobiology and Behavior, Univ. of California,<br />

Irvine, U.S.; 4 Dept. of Human Physiology and Pharmacology, Univ. of Rome “La Sapienza”,<br />

Italy<br />

119. Glia me<strong>di</strong>ates neuroprotection by estrogen against ß-amyloid toxicity: effect<br />

amplified by estrogen receptor overexpression<br />

Carbonaro Viviana 1 , Frasca G. 1 , Merlo S. 1 , Caraci F. 2 , Copani A. 2 , Sortino M.A. 2<br />

Departments of 1 Experimental and Clinical Pharmacology and 2 Pharmaceutical Sciences,<br />

University of Catania<br />

91<br />

120. Cannabi<strong>di</strong>ol in vivo suppresses A induced reactive gliosis<br />

Scuderi Caterina 1,2 , Esposito G. 1 , Savani C. 1,4 , De Filippis D. 2 , Iuvone T. 2 , Steardo L. 1<br />

1 Department of Human Physiology and Pharmacology “Vittorio Erspamer”, University of Rome<br />

“La Sapienza” -<br />

2 Department of Pharmacological Sciences, University of Palermo.<br />

3 Department of Experimental Pharmacology, University of Naples Federico II. 4 Department of<br />

Human Physiology and Pharmacology, University of Bari<br />

121. In vivo characterization of DKK-1 expression in transgenic animal models of<br />

Alzheimer's <strong>di</strong>sease<br />

Fiorentini Anna, Rosi M. C., Luccarini I., Grossi C., Casamenti F.<br />

Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy<br />

122. in vivo effect of Clioquinol treatment in a mouse model of Alzheimer’s <strong>di</strong>sease<br />

Grossi Cristina, Rosi M. C., Fiorentini A., Luccarini I. , Casamenti F.<br />

Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy<br />

123. Long-term treatment with a new anti-oligomeric beta-amyloid vaccine markedly<br />

reduces brain beta-amyloid load in a transgenic mouse model of Alzheimer's <strong>di</strong>sease<br />

Imbimbo Bruno P. 1 , Pietrini V., 2 Baroc M.F. 2 , Del Giu<strong>di</strong>ce E. 3 , Miccichè F. 3 , Colavito D. 3 ,<br />

D'Arrigo A. 3 , Dalle Carbonare M. 3 , Leon A. 3 , Villetti G. 1 , Facchinetti F. 1 , Moretto N. 4 , Ottonello<br />

S. 4<br />

1 Chiesi Farmaceutici, Via Palermo 26/A, Parma; 2 Department of Neurosciences, University of<br />

Parma, Parma; 3 Research & Innovation, Via Svizzera 16, Padua; 4 Department of Biochemistry<br />

and Molecular Biology, University of Parma, Viale G.P. Usberti 23/A, Parma<br />

pag_dx.indd 1 30/05/2007 4.20.22


124. Discovery of a series of molecules acting as potent alpha7 nAChR agonists with procognitive<br />

and neuroprotective properties<br />

Scali Carla 1 , Gianfriddo M. 1 , Bothmann H. 1 , Diodato E. 1 , Zanelli U. 1 , Caricasole A. 1 ,<br />

Gaviraghi G. 1 , Dunlop J. 2 , Roncarati R. 1 , Terstappen G.C. 1<br />

1 Siena Biotech SpA, Siena, ITALY, 2 Wyeth Research, Princeton, NJ, USA<br />

Farmacologia del dolore<br />

Poster 125 – 135<br />

125. Periaqueductal grey metabotropic glutamate receptor subtype 7 and 8 show<br />

opposite actions on amino acid release, nociceptive behaviour and rostral<br />

ventrome<strong>di</strong>al medulla ON and OFF cell activity<br />

Marabese Ida, Rossi F., Palazzo E., Vita D., Scafuro M.A., De Novellis V., Maione S.<br />

Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, The Second<br />

University of Naples, via Costantinopoli 16, 80138 Naples<br />

126. Role of the type 2 and 3 inositol 1,4,5-trisphosphate receptor in muscarinic<br />

antinociception in mice<br />

Vivoli Elisa, Galeotti N., Norcini M., Ghelar<strong>di</strong>ni C., Bartolini A.<br />

Department of Pharmacology – Viale G. Pieraccini, 6, 50139 – Florence<br />

92<br />

127. Involvment of type 1 and 3 ryano<strong>di</strong>ne receptor in mouse muscarinic antinociception<br />

Norcini Monica, Galeotti N., Vivoli E., Ghelar<strong>di</strong>ni, C., Bartolini A.<br />

Department of Pharmacology – Viale G. Pieraccini, 6, 50139 – Florence<br />

128. Detection and quantification of endogenous N/OFQ in the rat cerebrospinal fluid,<br />

under basal and stimulated con<strong>di</strong>tions<br />

Lopetuso Giuseppe, Romual<strong>di</strong> P., Candeletti S.<br />

Dip. Farmacologia - Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Bologna<br />

129. Impaired nociception in mice lacking the prokineticin receptor 2 (PKR2)<br />

Lattanzi Roberta, Giannini E., Melchiorri P., Negri L.<br />

Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy<br />

130. The central antinociceptive effect of N-arachidonoyl-phenolamine (AM404):<br />

implication of opioidergic and serotonergic systems<br />

Ruggieri Valentina a , Vitale G. a , Pini L. A. b , Sandrini M. a<br />

a Sect. of Pharmacology, Dept. of Biome<strong>di</strong>cal Sciences, University of Modena and Reggio E. b<br />

Clinical Pharmacology Unit, University of Modena and Reggio E<br />

131. 2-chloro-2’-C-methyl-N 6 -cyclopentyladenosine, a highly selective adenosine A1<br />

receptor agonist, has antinociceptive activity in the rat<br />

Gatta Luisa, Palazzo E., De Novellis V., Rossi F., Vita D., Maione S.<br />

Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, The Second<br />

University of Naples, via Costantinopoli 16, 80138 Naples<br />

132. 2-chloro-2’-C-methyl-N 6 -cyclopentyladenosine, a highly selective adenosine A1<br />

receptor agonist, modulates the ongoing and tail flick -related activity of RVM on<br />

and off cells<br />

Guida Francesca, Rossi F., Vita D., Marabese I., De Novellis V., Maione S.<br />

Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, The Second<br />

University of Naples, via Costantinopoli 16, 80138 Naples<br />

pag_sx.indd 1 30/05/2007 4.21.22


133. NGF-induced neurite outgrowth inhibition and pain control<br />

Restivo Alessandra, Salvati P., Caccia C.,<br />

Discovery, Newron Pharmaceuticals SpA, Bresso (MI), Italy<br />

134. Analgesic effects of new piridazione derivatives<br />

Pieretti Stefano 1 , Colucci M. 1 , Di Giannuario A. 1 , Maione F. 1,2 , Giovannoni M.P. 3 , Biancalani C. 3<br />

Dal Piaz V. 3<br />

1 Department of Drug Research and Evaluation, Italian National Institute of Health, Rome;<br />

2 Department of Experimental Pharmacology, University of Naples, “Federico II”; 3 Department<br />

of Pharmaceutical Sciences, University of Florence<br />

135. The protective effect of Olive oil phenols hydroxytyrosol and oleuropein on<br />

morphine tolerance<br />

Muscoli Carolina 1,2 , Procopio A. 1 , Vetrice D. 1 , Oliverio M. 1 , Arbitrio M. 3 , Rizzo M. 1 , Costa N. 1 ,<br />

Arcone R. 1 , Giovanni S. 4 , Rotiroti D. 1 , Nistico’ G. 5 , Salvemini D. 6 , Mollace V. 1<br />

1 Dept. of Pharmacobiol. Sciences, University of Catanzaro Magna Graecia, Italy; 2 San Raffaele<br />

Pisana IRCCS, Rome, Italy; 3 ISN-CNR; 4 Dept. of Chemistry, University of Calabria, Italy;<br />

5 Dept. of Biology, Univerity of “Tor Vergata”, Italy; 6 Dept. of Int. Med, Division of Pulmonary,<br />

Critical Care and Sleep Me<strong>di</strong>cine, Saint Louis University, St Louis, USA<br />

Farmacologia e tossicologia del comportamento<br />

Poster 136 – 150<br />

136. Neuropeptide S stimulates locomotor activity and wakefulness and evokes<br />

anxiolytic-like effects in mice<br />

1 Vergura Raffaella, 1 Rizzi A., 1 Marzola G., 2 Guerrini R., 2 Salvadori S., 1 Regoli D. 1 Calo’ G.<br />

1 Dept. of Pharmacology and 2 Dept of Pharmaceutical Science, University of Ferrara, Italy<br />

93<br />

137. Repeated restraint stress and anxiolytic drugs <strong>di</strong>fferentially modulate latent<br />

inhibition in C57BL6 mice<br />

Marcello Stefania a , Mongeau R. b , Andersen J. S. c , Pani L. d,a<br />

a Neuroscienze Pharmaness S.c.a.r.l., Cagliari.<br />

b NeuroPsychoPharmacologie, Faculté de<br />

Médecine Pitié-Salpêtrière, Paris, France. c Tofla Teld, Copenhagen, Denmark. d Istitute of<br />

Biome<strong>di</strong>cal Technologies, C.N.R., Milano<br />

138. Central administration of neuropeptide S (NPS) inhibits palatable food intake in the<br />

rat<br />

Fedeli Amalia, Economidou D., Braconi S., Cippitelli A., Massi M., Ciccocioppo R.<br />

Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy<br />

139. Quinpirole-induced compulsive drinking in rats is influenced by manipulation of<br />

behavioral cost<br />

Milella Michele S., Amato D., Ba<strong>di</strong>ani A., Nencini P.<br />

Department of Human Phisiology and Pharmachology, University of Rome Sapienza<br />

140. Disturbances of eating behavior during workplace suffering<br />

Milano Walter, Petrella C., Capasso A.*.<br />

Mental Health Operations Unit District 44 ASL Napoli 1 and *Department of Pharmaceutical<br />

Sciences, University of Salerno, Italy<br />

pag_dx.indd 1 30/05/2007 4.22.34


141. Effects of systemic MPTP administration on behavior and dopamine changes in<br />

<strong>di</strong>alysate from the striatum of freely moving mice<br />

Manca Antonio a , Bazzu G. a , Calia G. a , Puggioni G. a , Rocchitta G. a , Dedola S. a , Migheli R. a ,<br />

Serra P.A. a<br />

a Department of Pharmacology, Me<strong>di</strong>cal School, University of Sassari, Viale S. Pietro 43/b,<br />

07100, Sassari, Italy<br />

142. Role of dopamine D2-like receptors in the microstructure of licking for water and<br />

so<strong>di</strong>um chloride solutions in water deprived rats<br />

D'Aquila Paolo S., Carta D., Casula M.G., Dore B., Murgia E., Serra G.<br />

Department of Drug Sciences, University of Sassari, Sassari, Italy<br />

143. Single, intense prenatal stress can <strong>di</strong>fferently affect emotional behavioUr accor<strong>di</strong>ng<br />

to the nature of the task. Influence of metyrapone<br />

Noto Giovanna, Plescia F., Cannizzaro E., Gagliano M., Provenzano G.M., Cannizzaro C.<br />

Department of Pharmacological Sciences, University of Palermo, Italy<br />

144. Manipulations of glucocorticoid induced stress response may <strong>di</strong>fferently affect the<br />

acquisition of a reward-facilitated spatial/visual learning task<br />

Barrile Vita, Plescia F., Cannizzaro G., La Barbera M., Mantia G. , Cannizzaro C.<br />

Department of Pharmacological Sciences, University of Palermo<br />

94<br />

145. Behavioural effects induced by chronic treatment with Epigallocatechin gallate<br />

(EGCG), the major catechin of green tea, in spontaneously hypertensive rat (SHR)<br />

Lemoli Mariangela, Montagnani M. , De Salvia M. A.<br />

Dept. Pharmacology and Human Physiology, Me<strong>di</strong>cal School, University of Bari, Piazza G.<br />

Cesare, 70124 Bari, Italy<br />

146. Impact of antipsychotic treatments of behavioral alterations induced by paradoxical<br />

sleep deprivation<br />

Frau Roberto 1 , Orrù M. 1 , Mereu G. 3 , Gessa G. L.i 1 , Marrosu F. 2 Bortolato M. 2<br />

1 Dept. of Neuroscience “Bernard B. Bro<strong>di</strong>e”. University of Cagliari, Cagliari, Italy<br />

2 Dept. of Car<strong>di</strong>ovascular and Neurological Science. University of Cagliari, Cagliari, Italy<br />

3 Dept. of Experimental Biology “B. Loddo”. University of Cagliari, Cagliari, Italy<br />

147. Role of GABAB receptors in the balance of epileptic and psychotic-like phenomena in<br />

DBA/2J mice<br />

Bortolato Marco 1 , Frau R. 2 , Orrù M. 2 , Piras A. P. 2 , Gessa G. L.i 2 , Castelli M.P. 2 , Mereu G. 3 ,<br />

Marrosu F. 1<br />

1 Dept. of Car<strong>di</strong>ovascular and Neurological Science. University of Cagliari, Cagliari, Italy<br />

2 Dept. of Neuroscience “Bernard B. Bro<strong>di</strong>e”. University of Cagliari, Cagliari, Italy<br />

3 Dept. of Experimental Biology “B.Loddo”. University of Cagliari, Cagliari, Italy<br />

148. Training-associated emotional arousal <strong>di</strong>fferentially modulates cannabinoid effects<br />

on object recognition memory<br />

Campolongo Patrizia 1-2 , Scaccianoce S. 1 , Modafferi A. 1 , Trezza V. 1 , Roozendaal B. 3 , Schelling<br />

G. 4 , McGaugh J.L. 3 , Cuomo V. 1<br />

1 Dept. of Human Physiology and Pharmacology, Univ. of Rome “La Sapienza”, Rome, Italy;<br />

2 Dept. of Biochemical Sciences, Univ. of Foggia, Foggia, Italy; 3 Center for the Neurobiology of<br />

Learning and Memory, Univ. of California, Irvine, USA; 4 Dept. of Anaesthesiology, Ludwig-<br />

Maximilians-University, Munich, Germany<br />

pag_sx.indd 1 30/05/2007 4.23.55


149. Gender-related effects of PREGS on emotionality, learning and memory performance<br />

in adult rats<br />

Diliberto Irene, Plescia F., Cannizzaro G., Mantia G., Provenzano G. M., Cannizzaro C.<br />

Department of Pharmacological Sciences, University of Palermo<br />

150. Use of Energy drinks in association with alcoholic beverages in a cohort of students<br />

of the School of Me<strong>di</strong>cine of the University of Messina<br />

Oteri Alessandro, Salvo F., Caputi A.P., Calapai G.<br />

Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina<br />

Sostanze d'abuso<br />

Poster 151 – 173<br />

151. Gamma hydroxybutirate (GHB) modulates NPY-Y1 receptor signalling in the<br />

amygdala of transgenic mice through GABA B receptor in a neurosteroids<br />

independent manner<br />

Mele P. a , Serra M. b,c,d , Pisu M.G. b,d , Eva C. a , Biggio G b,c,d .<br />

a Dep. Of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, Section of Pharmacology, University<br />

of Turin, Italy. b Dep. of Experimental Biology, Sec. of Neuroscience, University of Cagliari,<br />

Cagliari, Italy. c Center of Excellence for the Neurobiology of Dependence, University of<br />

Cagliari, Cagliari, Italy. d C.N.R. Institute of Neuroscience, Cagliari, Italy<br />

152. Mapping brain activity following gamma-hydroxybutyric acid administration using<br />

functional magnetic resonance imaging in rats<br />

Muntoni Anna Lisa 1 , Lu Hanbing 2 , Scholl C. A. 2 , Pistis M. 3 , Stein E.A. 2<br />

1 CNR Institute of Neuroscience and 3 Department of Neuroscience, University of Cagliari, Italy<br />

2 Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, USA<br />

95<br />

153. Endocannabinoid system and nicotine withdrawal signs in mice<br />

Mannucci Carmen a , Pieratti A. a , Russo G. a , Caputi A. P. a , Calapai G. a<br />

a Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Section of<br />

Pharmacology, School of Me<strong>di</strong>cine, University of Messina, Italy<br />

154. Smoking cessation after the introduction of the law banning smoking in public<br />

places in Italy: a one-year follow-up study<br />

Grassi Maria Caterina*, Enea D.**, Nencini P.*<br />

*Department of Human Physiology and Pharmacology “V. Erspamer”. **Centro Policlinico<br />

Senza Fumo, “Sapienza” University of Rome, Italy<br />

155. Smoking cessation and body weight<br />

Grassi Maria Caterina*, Enea D.**, Marchetti R.**, Temperilli F.***, Villarosa F.***,<br />

Nencini P.*, Cuzzolaro M.***<br />

*Department of Human Physiology “V.Erspamer”, **Centro Policlinico Senza Fumo,<br />

***Department of Clinical Me<strong>di</strong>cine, “Sapienza” University of Rome, Italy<br />

156. Preliminary results in pivotal study on biomarkers related to smoking habits<br />

Calapai Gioacchino a , Moran<strong>di</strong> S. b , Mannucci C. a , Nunziata A. b , Caputi A. a , Bassi A. b<br />

a Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina -<br />

b BAT Italia S.p.A. R&D Via Amsterdam147, Rome<br />

157. Altered expression of metabotropic glutamate receptors in the nucleus accumbens<br />

during opiate dependence and withdrawal in the rat<br />

Modafferi Antonella M.E 1 ., Diana M. 2 , Scaccianoce S. 1<br />

1 Dept. of Human Physiology and Pharmacology - University of Rome La Sapienza; 2 Dept. of<br />

Drug Sciences - University of Sassari<br />

pag_dx.indd 1 30/05/2007 4.25.15


158. Time-dependent morphological and biochemical changes during morphine<br />

withdrawal in the rat nucleus accumbens<br />

Vinci Stefania 1 , Marinelli A. 2 , Olla A. 2 , Ibba F. 1 , Diana M. 3 , Spiga S. 2 , Acquas E. 1,4<br />

1 Department of Toxicology and 4 Centre of Excellence on Neurobiology of Ad<strong>di</strong>ction, University<br />

of Cagliari; 2 Department of Animal Biology and Ecology, University of Cagliari; 3 Department of<br />

Drug Sciences , University of Sassari<br />

159. Reciprocal effects of response contingent and non-contingent intravenous heroin on<br />

in vivo nucleus accumbens shell versus core dopamine: a repeated sampling<br />

micro<strong>di</strong>alysis study<br />

Cacciapaglia Fabio 1 , Lecca D. 1,2 , Valentini V. 1,2 , Di Chiara G. 1,2,3<br />

1 Department of Toxicology, 2 Centre of Excellence for <strong>Stu<strong>di</strong></strong>es on Ad<strong>di</strong>ctions and 3 Institute of<br />

Neuroscience, Consiglio Nazionale delle Ricerche (CNR), University of Cagliari, Italy<br />

160. Role of dopamine D 1 receptor in morphine- and lithium-induced con<strong>di</strong>tioned<br />

saccharin avoidance<br />

Simola Nicola, Fenu S., Rivas E., Di Chiara G.<br />

Department of Toxicology and Centre of Excellence for Neurobiology of Dependence,<br />

University of Cagliari, Cagliari, Italy<br />

96<br />

161. Dissociation in the modulatory effects of environment on heroin-induced<br />

psychomotor sensitization vs. heroin self-administration<br />

Celentano Michele, Caprioli D., Nencini P., Ba<strong>di</strong>ani A.<br />

Department of Human Physiology and Pharmacology, University of Rome Sapienza<br />

162. Methadone and buprenorphine maintenance effects on immune system function:<br />

comparison with untreated heroin ad<strong>di</strong>ctcs<br />

Somaini Lorenzo 1 , Franchi S. 2 , Leccese V. 1 , Gerra G. 3 , Panerai A. E 2 , Sacerdote P. 2<br />

1 Ad<strong>di</strong>ction Treatment Centre, Health Local Unit ASL 12 Biella. 2 Department of Pharmacology,<br />

via Vanvitelli 32, 20129 Milano. 3 Health Local Unit AUSL Parma<br />

163. The role of liver cytochrome isoforms on buprenorphine metabolism and it’s clinical<br />

relevance<br />

Somaini Lorenzo 1 , Gola M. 2<br />

1 2<br />

Ad<strong>di</strong>ction Treatment Centre, Health Local Unit ASL 12 Biella. Laboratory of<br />

Pharmacogenetics Lugano (CH)<br />

164. Anabolic androgenic steroids influence the expression of brain nerve growth factor<br />

in the rat<br />

Carretta Maria Teresa*, D’Amico D.*, Pace S., Modafferi A. M.E., Salemi M., Togna G.I.,<br />

Scaccianoce S.<br />

Dept. of Human Physiology and Pharmacology - University of Rome La Sapienza<br />

165. Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic<br />

neuronal death in mixed mouse cortical cultures<br />

Orlando Rosamaria 1* , Caruso A. 1* , Molinaro G. 2 , Motolese M. 1 , Matrisciano F. 1 , Togna G. 1 ,<br />

Melchiorri D. 1 , Nicoletti F. 1,2 , Bruno V. 1,2<br />

1 Istituto Neurologico Me<strong>di</strong>terraneo Neuromed, Pozzilli, Italy; 2 Department of Human<br />

Physiology and Pharmacology, University of Rome “La Sapienza”, Rome, Italy<br />

166. Effect of nandrolone and stanozolol on pro-inflammatory cytokine production by<br />

human macrophages<br />

Trefiletti Giuliana*, Togna A.R.*, Pacifici R.**, Bacosi A.**, Di Carlo S.** Togna G.I.*<br />

* Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”<br />

**Department of Therapeutic Research and Me<strong>di</strong>cines Evaluation, Istituto Superiore <strong>di</strong> Sanità,<br />

Rome<br />

pag_sx.indd 1 30/05/2007 4.27.01


167. The K-Opioid receptor agonist U-69593 prevents cocaine-induced DARPP-32<br />

phosphorylation at THR34 in the rat brain<br />

D´Addario Clau<strong>di</strong>o, Di Benedetto M., Candeletti S., Romual<strong>di</strong> P.<br />

Dept of Pharmacology - University of Bologna - via Irnerio 48, 40126 BOLOGNA<br />

168. Facilitation of con<strong>di</strong>tioned reinstatement of cocaine-seeking following central<br />

administration of neuropeptide S<br />

Kallupi Marsida, Economidou D., Cannella N., Stopponi S., Ciccocioppo R.<br />

Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy<br />

169. Environmental modulation of cocaine and amphetamine seld administration<br />

Caprioli Daniele, Celentano M., Nencini P., Ba<strong>di</strong>ani A.<br />

Department of Human Physiology and Pharmacology, University of Rome La Sapienza<br />

170. Increased toxicity of cocaine adulterated with atropine: efficacy of <strong>di</strong>azepam<br />

Zani Alessia, Braida D., Rossoni G., Gori E. a , Capurro V., Sala M.<br />

Department of Pharmacology, Chemotherapy and Me<strong>di</strong>cal Toxicology, and a Behavioural<br />

Pharmacology and Drug Dependence Center, University of Milan, Via Vanvitelli 32, 20129,<br />

Milan, Italy<br />

171. Role of CREB in the prodynorphin gene expression regulation by MDMA<br />

Di Benedetto Manuela, Porticella E, D´Addario C, Candeletti S, Romual<strong>di</strong> P<br />

Dept of Pharmacology - University of Bologna - via Irnerio 48, 40126 BOLOGNA<br />

172. 3,4-methylen<strong>di</strong>oxymethamphetamine (ecstasy) induces formation of reactive<br />

oxygen species and tau protein phosphorilation in the hippocampus<br />

Busceti Carla L. 1 , Biagioni F. 1 , Riozzi B. 1 , Storto M. 1 , Battaglia G. 1 , Fornai F. 1,3 Bruno V. 1,5 ,<br />

Nicoletti F. 1,5<br />

1 I.N.M. Neuromed, Pozzilli, Italy; 2 Dept. of Neuropathol., Univ. of Amsterdam, The<br />

Netherland; 3 Dept. of Hum. Morphol. and Applied Biol., Univ. of Pisa, Italy; 4 SienaBiotech,<br />

Siena, Italy; 5 Dept. of Hum. Physiol. and Pharmacol., Univ. “La Sapienza”, Rome, Italy<br />

97<br />

173. Pharmacological and toxicological properties of Smart Drugs<br />

Oteri A. a , Calapai G. a , Pichini S. b , Zuccaro P. b , Palmi I. b , Caputi A.P. a,c<br />

a Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina<br />

b Istituto Superiore <strong>di</strong> Sanità, Rome. c IRCCS Centro Neurolesi ‘‘Bonino-Pulejo’’, Messina, Italy<br />

Faramacologia dell'apparato <strong>di</strong>gerente<br />

Poster 174 – 186<br />

174. Inhibitory modulation of the non-adrenergic non-cholinergic relaxation of the rat<br />

gastric fundus by nociceptin/orphanin FQ and related peptides<br />

Currò Diego, De Marco T., Martucci D., Preziosi P.<br />

Institute of Pharmacology, School of Me<strong>di</strong>cine, Catholic University of the Sacred Heart, Rome,<br />

Italy<br />

175. Nociceptin/orphanin FQ prevents gastric damage induced by acute stress in the rat<br />

by acting in the periphery<br />

Morini Giuseppina a , Gran<strong>di</strong> D. a , Solinghi E. a , Guerrini R. b , Polidori C. c , Massi M. c<br />

a Department of Human Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of Parma,<br />

PARMA; b Department of Pharmaceutical Sciences and Biotechnology Center, University of<br />

Ferrara, Ferrara; c Department of Experimental Me<strong>di</strong>cine and Public Health, University of<br />

Camerino, Camerino, Italy<br />

pag_dx.indd 1 30/05/2007 4.27.57


176. Gastroprotective effects of the selective histamine H 3 receptor agonists methimepip<br />

and immethri<strong>di</strong>ne<br />

1 Adami Maristella, 1 Guaita E., 2 De Esch I.J.P., 2 Leurs R., 3 Stark H., 1 Coruzzi G.<br />

1 Department of Human Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of Parma,<br />

Italy; 2 LACDR, Department of Me<strong>di</strong>cinal Chemistry, Vrije Universiteit Amsterdam, The<br />

Netherlands; 3 Institut für Pharmazeutische Chemie, J W Goethe-Universität, Frankfurt,<br />

Germany<br />

177. The gastric effect of UFP 112, a new NOP receptor agonist, in physiologiacl and<br />

pathological con<strong>di</strong>tions<br />

Petrella Carla a , Agostini S. a , Broccardo M. a , Guerrini R. b , Improta G. a , Morini G. c<br />

a Dept. Human Physiology and Pharmacology University of Rome “La Sapienza”, b Dept.<br />

Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, c Dept. of Human<br />

Anatomy, Pharmacology and Forensis Me<strong>di</strong>cine, University of Parma –ITALY<br />

178. Effects of cyclooxygenase inhibitors on molecular mechanisms implicatd in gastric<br />

ulcer healing<br />

Colucci Rocchina 1 , Ghisu N. 1 , Antonioli L. 1 , Fornai M. 1 , Bernar<strong>di</strong>ni N. 2 , Ippolito C. 2 , Natale G. 2 ,<br />

Del Tacca M. 1 , Blan<strong>di</strong>zzi C. 1<br />

1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, 2 Department<br />

of Human Morphology and Applied Biology, University of Pisa, Italy<br />

98<br />

179. Dual effects of ticlopi<strong>di</strong>ne during formation and healing of ethanol-induced gastric<br />

lesions in the rat: comparison with aspirin<br />

Rapetti D. 1 , Guidobono F. 2 , Soglian A. 3 , Locatelli V. 1 , De Luca V. 2 , Sibilia V. 2<br />

1 Department of Experimental Me<strong>di</strong>cine, University of Milano- Bicocca, Monza, Italy<br />

2 Department of Pharmacology, Chemotherapy and Me<strong>di</strong>cal Tossicology, University of Milan,<br />

Italy<br />

3 Me<strong>di</strong>cal Department, Pharmaceutical Division, Bayer HealthCare, Milan, Italy<br />

180. Involvement of PKC in the adaptive changes of opioid receptos in the myenteric<br />

plexus after chronic sympathetic denervation<br />

1 Zanetti Elena, 1 Oldrini R., 2 Pascale A., 1 Canciani L., 1 Giuliani D., 2 Ama<strong>di</strong>o M., 3 Chiaravalli A.,<br />

1 Giaroni C., 1 Lecchini S., 1 Frigo G.<br />

1 Clinical and Applied Pharmacology Interuniversity Centre, University of Insubria and<br />

University of Pavia; 2 Experimental and Applied Pharmacology Dept, University of Pavia; 3 Dept.<br />

of Surgical Pathology Ospedale <strong>di</strong> Circolo of Varese<br />

181. Altered expression and phosphorylation of NMDA NR1 subunits in the myenteric<br />

plexus during hypoxia-hypoglicaemia<br />

1 Giaroni Cristina, 1 Zanetti E., 1 Giuliani D., 1 Oldrini R., 1 Bianchi F., 1 Moro E., 2 Trinchera M.,<br />

1 Crema F., 1 Lecchini S., 1 Frigo G.<br />

1 Clinical and Applied Pharmacology Interuniversity Centre, Universities of Insubria and Pavia,<br />

2 Department of Experimental and Clinical Biome<strong>di</strong>cal Sciences, University of Insubria<br />

182. Melatonin reverses LPS-induced gastro-intestinal motility <strong>di</strong>sturbances through the<br />

inhibition of oxidative stress<br />

De Filippis Daniele 1 , Esposito G. 3 , D’Amico A. 1 , De Man J.G. 2 , De Winter B.Y. 2 , Steardo L. 3 ,<br />

Iuvone T. 1<br />

1<br />

Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples<br />

Federico II, Via D. Montesano 49, 80131 Naples, Italy. 2 Division of Gastroenterology, Faculty<br />

of Me<strong>di</strong>cine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.<br />

3 Department of Human Physiology and Pharmacology “Vittorio Erspamer”Faculty of Pharmacy<br />

University of Rome “La Sapienza” Piazza A. Moro 5, 00151 Roma (Italy)<br />

pag_sx.indd 1 30/05/2007 4.29.17


183. The cannabinoid WIN 55212 inhibits pancreatic amylase secretion via cholinergic<br />

suppression<br />

Agostini Simona, Broccardo M., Improta G., Petrella C., Linari G.<br />

Dept. of Human Physiology and Pharmacology. University “La Sapienza”, Rome<br />

184. Sera of celiac patients with neurological <strong>di</strong>sorders evoke a mitochondrial-dependent<br />

apoptosis in human SH-Sy5Y neuroblastoma cells<br />

Cervio Elisabetta*, Volta U.°, Verri M.*, Boschi F.*, Pastoris O.*, Granito A.°, De Giorgio R.^,<br />

Tonini M.*<br />

*Dept of Phys & Pharm Sci, Univ Pavia; Dept of °Int Med, Car<strong>di</strong>oangiol, Hepatol & ^Int Med &<br />

Gastroenterol, Univ of Bologna, Italy<br />

185. Expression and function of the bradykinin B1 receptor in normal and inflamed<br />

human gallbladder<br />

Andre Eunice 1 , Gazzieri D. 1 , Bardella E. 1 , Ferreira J. 3 , Mori M.A. 4 , Bader M. 4 , João B.C. 5 , De<br />

Giorgio R. 6 , Corinaldesi R. 6 , Geppetti P. 1 , Trevisani M. 1<br />

1 Pharmacology Unit, University of Ferrara, 3 Dep. of Chemistry, Universidade Federal de Santa<br />

Maria, 4 Max Delbrück Center for Molecular Me<strong>di</strong>cine, Berlin-Buch, 5 Dep. of Pharmacology,<br />

Universidade Federal de Santa Catarina, Florianópolis, 6 Dep. Int. Med. and Gastroent.,<br />

University of Bologna<br />

186. A community pharmacies survey on prevalence of constipation and risk factors for<br />

laxative use in the local health <strong>di</strong>stricts of Verbania and Messina<br />

Morreale Ilaria (1) , Salvo F. (1) , Polimeni G. (1) , Vighi E. (2) , Poggi L. (2) , Dossi G. (2) , Rossitto<br />

A. (3) , De Sarro A. (1) , Calapai G. (1) , Caputi A.P. (1)<br />

(1) Dep. Clin Experim Med and Pharmacol, University of Messina, Italy. (2) Local Health District<br />

N. 14 (Verbano/Cusino/Ossola), Verbania, Italy<br />

99<br />

Farmacologia del metabolismo e del sistema endocrino<br />

Poster 187 – 195<br />

187. Exenatide achieved equivalent glycemic control to insulin glargine with weight<br />

reduction, independently from baseline BMI, in metformin and sulfonylurea-treated<br />

type-2 <strong>di</strong>abetes<br />

Gentilella Raffaella 4 ; Heine R.J. 1 ; Van Gaal L.F. 2 ; Johns D. 3 ; Mihm .J. 3 ; Widel M.H. 3 ; Brodows<br />

R.G. 3<br />

1 Diabetes Center, Department of Endocrinology, VU University Me<strong>di</strong>cal Center, Amsterdam,<br />

The Netherlands; 2 Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of<br />

Me<strong>di</strong>cine, University Hospital Antwerp, Belgium; 3 Lilly Research Laboratories, Eli Lilly and<br />

Company, In<strong>di</strong>anapolis, IN, USA; 4 Eli Lilly Italy, Florence, Italy<br />

188. Effects of exenatide compared with twice-daily biphasic insulin aspart in patients<br />

with type 2 <strong>di</strong>abetes using metformin and a sulphonylurea<br />

Gentilella Raffaella 5 , Nauck M.A. 1 , Duran Garcia S. 2 , Kim D. 3 , Johns D. 4 , Festa A. 4 , Trautmann<br />

M. 4<br />

1 Clinical Diabetology, Diabeteszentrum Bad Lauterberg, Germany, 2 Cátedra de Endocrinología,<br />

Hospital de Valme, Seville, Spain, 3 Amylin Pharmaceuticals, Inc., San Diego, United States,<br />

4 Lilly Research Laboratories, Eli Lilly and Company, In<strong>di</strong>anapolis, United States; 5 Eli Lilly Italy,<br />

Florence, Italy<br />

pag_dx.indd 1 30/05/2007 4.30.39


189. A comparison of exenatide and insulin glargine in patients using a single oral<br />

anti<strong>di</strong>abetic agent<br />

Gentilella Raffaella 5 ,Barnett A.H. 1 , Trautmann M. 2 , Burger J. 3 , Johns D. 3 , Kim D. 4 , Brodows<br />

R. 3 , Festa A. 2 , Roberts A. 2<br />

1 Department of Diabetes/Endocrinology, Birmingham Heartlands Hospital, United Kingdom,<br />

2 Eli Lilly and Company, Hamburg, Germany, 3 Eli Lilly and Company, In<strong>di</strong>anapolis, United<br />

States, 4 Amylin Pharmaceuticals, Inc., San Diego, United States; 5 Eli Lilly Italy, Florence, Italy<br />

190. Safety and efficacy of exenatide over 16 weeks in patients with type 2 <strong>di</strong>abetes<br />

mellitus using a thiazoli<strong>di</strong>ne<strong>di</strong>one with or without metformin<br />

Gentilella Raffaella 6 , Zinman B. 1 , Hoogwerf B. 2 , Duran Garcia S. 3 , Milton D. 4 , Giaconia J. 4 , Kim<br />

D. 5 , Trautmann M. 7 , Brodows R. 4<br />

1 Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada, 2 Department of<br />

Endocrinology, Cleveland Clinic Foundation, Cleveland, USA, 3 Cátedra de Endocrinología,<br />

Hospital de Valme, Sevilla, Spain, 4 Eli Lilly and Company, In<strong>di</strong>anapolis, USA, 5 Amylin<br />

Pharmaceuticals, Inc., San Diego, USA, 6 Eli Lilly Italy, Florence, Italy, 7 Eli Lilly and Company,<br />

Hamburg, Germany<br />

191. Beta-cell function is markedly reduced in women with previous gestational <strong>di</strong>abetes<br />

Canu Silvia 1 , Franconi F. 1 , Tesi F. 2 , Seghieri G. 2<br />

1 Dpt. of Pharmacology, University of Sassari, Italy. 2 Dpt. of Internal Me<strong>di</strong>cine, Spedali Riuniti,<br />

Pistoia<br />

100<br />

192. Concentration of brain natriuretic peptide in women with gestational <strong>di</strong>abetes<br />

2 Campesi Ilaria,<br />

1 Tesi F., 1 Gironi A. 2 Canu S., 2 De Bellis A., 1 Anichini R., 1 Seghieri G.,<br />

2 Franconi F.<br />

1 Dpt. of Internal Me<strong>di</strong>cine, Spedali Riuniti, Pistoia, 2 Dpt. of Pharmacology, University of<br />

Sassari, Italy<br />

193. Biochemical mechanisms underlying endocannabinoid dysregulation in the pancreas<br />

and a<strong>di</strong>pose tissue of high fat <strong>di</strong>et-fed mice<br />

Matias Isabelle 1 , Starowicz K. 1 , Cristino L. 2 , Racioppi A. 1 , Di Marzo V. 1<br />

1,2 Endocannabinoid Research Group, 1 Institute of Biomolecular Chemistry and 2 Institute of<br />

Cybernetics, Consiglio Nazionale delle Ricerche, Pozzuoli (NA), Italy<br />

194. Ghrelin and des-acyl ghrelin inhibit isoproterenol-induced lipolysis in rat a<strong>di</strong>pocytes<br />

through activation of phospho<strong>di</strong>esterase 3B<br />

Baragli Alessandra, Ghè C., Arnoletti E., Muccioli G.<br />

Division of Pharmacology, Department of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine,<br />

University of Turin, Turin, Italy<br />

195. Pharmacological modulation of metabolic, hormonal, and inflammatory alterations<br />

in an experimental model of hepatic steatosis<br />

1 Iacono Anna, 1,4 Esposito E., 1 Mattace Raso G., 2 Bianco G., 3,4 Cuzzocrea S., 1 Meli R.<br />

1 Department of Experimental Pharmacology, University of Naples “Federico II”, Naples;<br />

2 Department of Pharmaceutical Sciences, University of Salerno; 3 Department of Clinical and<br />

Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine, University of Messina, Messina;<br />

4 IRCCS Centro Neurolesi "Bonino-Pulejo," Messina, Italy<br />

pag_sx.indd 1 30/05/2007 4.34.12


Farmacologia della <strong>di</strong>sfunzione erettile<br />

Poster 196 – 201<br />

196. Involvement of mitogen-activated protein kinases (MAPKS) during testicular<br />

ischemia-reperfusion injury in nuclear factor-kB knock-out mice<br />

Minutoli Letteria 1 , Bitto A. 1 , Polito F. 1 , Fiumara T. 1 , Squadrito F. 1 , Mioni C. 2 , Antonuccio P. 3 ,<br />

Romeo C. 3 , Marini H. 4 , Guarini S. 2 Caputi A. P. 1 , Altavilla D. 1 .<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Univ of Messina 2 Dept<br />

of of Biomed Sci, Univ of Modena and Reggio Emilia, 3 Department of Med and Surg Pe<strong>di</strong>atric<br />

Sci, 4 Dept of Biochem, Physiol and Nutr Sci, University of Messina, Italy<br />

197. Stimulation of dopamine receptors in the paraventricular nucleus of the<br />

hypothalamus of male rats induces penile erection and increases extra-cellular<br />

dopamine in the nucleus accumbens: involvement of central oxytocin<br />

Succu Salvatora, Sanna F., Melis T., Argiolas A., Melis M.R.<br />

Bernard B. Bro<strong>di</strong>e Department of Neuroscience, University of Cagliari, Italy<br />

198. Influence of a cannabinoid CB 1 receptor antagonist, SR141716, on sexual behavior<br />

of male rats<br />

Zanoli Paola, Zavatti M., Montanari C., Rivasi M., Poggioli R., Benelli A.<br />

Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, University of Modena and<br />

Reggio Emilia, Modena, Italy<br />

199. Hydrogen sulfide (H 2 S) relaxes human and rabbit corpus cavernosum in vitro<br />

Romina Nassini 1 , Patacchini R. 2 , Materazzi S. 1 , Mondaini N. 1 , Natali A. 1 , Geppetti P. 1 ,<br />

Harrison S. 1<br />

1 Department of Critical Care Me<strong>di</strong>cine & Surgery, University of Florence, Florence, Italy; and<br />

2 Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy; Florence, Italy<br />

101<br />

200. Eurycoma longifolia improves copulatory activity of sexually sluggish rats<br />

Montanari Caterina, Zavatti M., Zanoli P., Baral<strong>di</strong> M.<br />

Dept. of Biome<strong>di</strong>cal Sciences, Section of Pharmacology and National InterUniversity<br />

Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and<br />

Reggio Emilia, Modena, Italy<br />

201. The tight-skin mice as a genetic model of Peyronie's-like <strong>di</strong>sease<br />

1,2 d’Emmanuele <strong>di</strong> Villa Bianca Roberta, 1,2 Sorrentino R., 3 Lungarella G., 1 Longo N., 1 Imbimbo<br />

C. 1 Mirone V. 1,2 Cirino G.<br />

1 Center for Preclinical and Clinical Research in Sexual Me<strong>di</strong>cine (CIRMS), 2 Department of<br />

Experimental Pharmacology, University of Naples Federico II,<br />

3 Departement of<br />

Physiopathology, Experimental Me<strong>di</strong>cine and Public Health, University of Siena<br />

Farmacologia dell'infiammazione<br />

Poster 202 – 213<br />

202. Pharmacological activity of selective COX-1 and COX-2 inhibitors in endothelial cells<br />

Sala Angelo, Bolego C., Buccellati C., Folco G.,<br />

Department of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan<br />

Italy<br />

203. Role of FGFR1 in the angiogenic response induced by PGE2<br />

Finetti Federica, Ziche M., Donnini S.<br />

Pharmacology section, Department of Molecular Biology, University of Siena<br />

pag_dx.indd 1 30/05/2007 4.36.33


204. Time course of brain PGE 2 level and synthesis pathway in LPS- fevered rats<br />

Di Matteo Anna, Bartella C., Mangano G., Apicella C., Mancini F., Coletta I., Guglielmotti A.,<br />

Polenzani L.<br />

Angelini Farmaceutici – ACRAF S.p.A Piazzale della Stazione S.Palomba-Pomezia Italy<br />

205. Brain Prostanoids profile in control and LPS-treated rats<br />

Bartella Cristina, Garrone B.e, Basta F., De Santi S., Vitiello M., Coletta I., Guglielmotti A.,<br />

Polenzani L.<br />

Angelini Farmaceutici – ACRAF S.P.A Piazzale della Stazione S.Palomba-Pomezia Italy<br />

206. Cysteinyl leukotrienes in human endothelial cells: synthesis and activities<br />

Sala Angelo , Carnini C., Accomazzo M.R., Borroni E., Vitellaro-Zuccarelli L., Folco G., Rovati<br />

G.<br />

Department of Pharmacological Sciences, Department of Biomolecular Sciences and<br />

Biotechnology, and Center for Car<strong>di</strong>opulmonary Pharmacology, University of Milan, 20133<br />

Milan, Italy<br />

207. Nitric-oxide scavenging properties of novel organic compounds containing cobalt<br />

(II) and ruthenium (III)<br />

1 Cantore Miriam, 2 Valtancoli B., 3 Cinci L., 2 Bencini A., 1 Ciuffi M., 1 Failli P.<br />

Depts. of: 1 Preclinical & Clinical Pharmacology,<br />

2 Chemistry and 3 Anatomy, Histology &<br />

Forensic Me<strong>di</strong>cine, University of Florence, Italy<br />

102<br />

208. Inhibition of nitric oxide pathway by an acetonic extract from Feijoa sellowiana<br />

berg. fruits<br />

Rossi Antonietta 1,2 , Pergola C. 1 , Formisano C. 3 , Guerriere L. 3 , Sautebin L. 1<br />

1 Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy;<br />

2 IRCCS Centro Neurolesi “Bonino-Pulejo”, University of Messina, Messina, Italy; 3 Department<br />

of Chemistry of Natural Products, University of Naples Federico II, Naples, Italy<br />

209. NCX 2057, a nitric oxide-derivative of ferulic acid, exerts anti-inflammatory activity<br />

in in-vitro and in-vivo models<br />

Ronchetti Daniela, Borghi V., Bion<strong>di</strong> S., Impagnatiello F.<br />

Nicox Research Institute, Bresso, Milan, Italy<br />

210. NCX 4040, a nitric oxide-donating aspirin derivative with improved antiinflammatory<br />

properties<br />

Anzellotti Paola, Di Francesco L., Tacconelli S., Patrignani P.<br />

Department of Me<strong>di</strong>cine and Center of Excellence on Aging, School of Me<strong>di</strong>cine, “G.<br />

d’Annunzio” University; †“G. d’Annunzio” University Foundation, Ce.S.I<br />

211. Evidence of cytokines levels modulation in rat serum exerted by Iacvita, a new<br />

antioxidant compound<br />

Ricchi Lucia, Corsi L., Geminiani E., Baral<strong>di</strong> M.<br />

Dip. Scienze Biome<strong>di</strong>che Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Modena e Reggio Emilia<br />

CINSPAN Consorzio Interuniversitario Nazionale per lo <strong>Stu<strong>di</strong></strong>o dei Principi Attivi Naturali<br />

212. Rapid release of annexin A1 following heat-shock response in LPS-stimulated<br />

macrophages<br />

Festa Michela, Parente L., Flower R. J. * , Perretti M. * , D’Acquisto F. * , Ercolino S.F.<br />

Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy. * William Harvey<br />

Research Institute, Dept. of Biochemical Pharmacology, Charterhouse Square, London,<br />

England<br />

pag_sx.indd 1 30/05/2007 4.38.13


213. Estrogen receptor antagonist ICI 182,780 inhibits the anti-inflammatory effect of<br />

glucocorticoids<br />

1,2 Salvatore Cuzzocrea, 3 Bruscoli S., 1 Crisafulli C., 1,2 Mazzon E., 3 Agostini M., 1 Muià C.,<br />

2,4 Esposito E.,<br />

3 Di Virgilio R.,<br />

4 Meli R.,<br />

5 Vegeto E.,<br />

5 Maggi A.,<br />

3 Riccar<strong>di</strong> C.<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina,<br />

Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy; 3 Department of Cinical and<br />

Experimental Me<strong>di</strong>cine, Pharmacology, University of Perugia, Italy;<br />

4 Department of<br />

Experimental Pharmacology, University of Naples “Federico II”, Naples Italy; 5 Department of<br />

Pharmacological Sciences, University of Milan, Italy<br />

Chemioterapia antibatterica, antivirale e antineoplastica<br />

Poster 214 – 228<br />

214. Synergistic cytotoxicity and pharmacogenetics of gemcitabine and ZD6474 in<br />

bladder cancer cell lines<br />

Mey Valentina, Elisa G., Nannizzi S., Ricciar<strong>di</strong> S., Danesi R., Del Tacca M.<br />

Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine,<br />

University of Pisa<br />

215. Synergistic cytotoxycity, inhibition of AKT and C-KIT phosphorylation, modulation of<br />

gene expression by sorafenib and gemcitabine in human pancreatic cancer cells<br />

Ricciar<strong>di</strong> Simona, Giovannetti E. , Nannizzi S., Mey V., Pasqualetti G., Danesi R., Del Tacca<br />

M.<br />

Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />

Pisa<br />

216. Inhibition of STAT 3 increases doxorubicin sensitivity in a human metastatic breast<br />

cancer cell line<br />

Roberta Molteni, Ravizza R., Garibol<strong>di</strong> M.B., Monti E.<br />

Dept. of Structural and Functional Biology, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> dell’Insubria<br />

103<br />

217. In vitro study of the interaction between gemcitabine and sorafeniv in non small<br />

cell lung cancer (NSCLC) A549 cell line<br />

Pasqualetti Giuseppe, Ricciar<strong>di</strong> S., Nannizzi S., Mey V., Elisa G., Danesi R., Del Tacca M.<br />

Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine - University of<br />

Pisa<br />

218. In vitro and in vivo antineoplastic effects of a novel platinum bioconjugate using a<br />

biocompatible polymeric matrix<br />

Garibol<strong>di</strong> Marzia Bruna, Gabano E. 1 , Sparnacci K. 1 , Laus M. 1 , Osella D. 1 , Ravizza R., Molteni<br />

R., Monti E.<br />

DBSF – Pharmacology Section, University of Insubria, Busto Arsizio (VA). 1 Dipartimento <strong>di</strong><br />

Scienze dell’Ambiente e della Vita, Università del Piemonte Orientale “A. Avogadro”,<br />

Alessandria<br />

219. Toxicological evaluation of mepacrine and interferon alfa-2A on U87-MG and Vero<br />

cell colture<br />

Coppi Andrea, Baggio G., Bruni E. Rossi T.<br />

University of Modena and Reggio Emilia- Italy: Departmentof Biome<strong>di</strong>cal Sciences-<br />

Section of Pharmacology; 287 G. Campi st 41100 Modena Italy<br />

pag_dx.indd 1 30/05/2007 4.39.14


220. Pro-oxidant and antitumor effects of curcumin and N-ethylmaleimide in the<br />

HA22T/VGH model of Overt hepatocellular carcinoma<br />

Carina Valeria, Labbozzetta M., Poma P., Alaimo A., Maurici A., Inguglia L., Notarbartolo M.,<br />

D’Alessandro N.<br />

Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Palermo<br />

221. HDAC inhibitors restore the p53 pathway in neuroblastoma cells<br />

Gnemmi Ilaria, Condorelli F., Genazzani A.A., Canonico P.L.<br />

DiSCAFF&DFB Center, Università del Piemonte Orientale, Novara, Italy<br />

222. Temperature influence on cellular uptake, DNA platination and antiproliferative<br />

activity of platinum(II) drugs<br />

Colangelo Donato a , Gabano E. b , Osella D. b , Viano I. a<br />

a Dept. Me<strong>di</strong>cal Sciences, Via Solaroli 17 I-28100 Novara, b Dept. of Ambiental and Life<br />

Sciences, via Bellini 25/G, I-15100 Alessandria, Università del Piemonte Orientale “A.<br />

Avogadro”, Italy<br />

223. Inhibition of P-GP/ATPASE activity of rat small intestine membrane vesicles by the<br />

novel, <strong>di</strong>hydropyri<strong>di</strong>ne MDR REVERTER DP7<br />

Alderighi Daniela, Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi F., Shah A.,<br />

Kawasae M., Motohashi N., Molnar J., Sgaragli G.<br />

Dipartimento <strong>di</strong> scienze biome<strong>di</strong>che, Università Degli <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena via A. Moro 2, 53100<br />

Siena<br />

104<br />

224. High energy shock waves increase paclitaxel efficacy in a syngenic model of breast<br />

cancer<br />

Canaparo Roberto 1,2 , Serpe L. 2 , Ean<strong>di</strong> M. 2 , Zara G.P. 2 , Berta L. 1 , Frairia R. 1<br />

1 Department of Clinical Pathophysiology, University of <strong>Torino</strong>, <strong>Torino</strong>, Italy. 2 Department of<br />

Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of <strong>Torino</strong>, <strong>Torino</strong>, Italy<br />

225. Evaluation of synthetic "tubulysin U" induced cytotoxycity in HL60, C6, PC12 and<br />

ECV304 cell lines<br />

Manca Ilaria a , Sani M. b,c , Sanna A. a , Fossati G. b , Lazzari P. a , Huguenot F. b , Pani L. a,d , Zanda<br />

M. b<br />

a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />

(CA), Italy. b C.N.R. Istituto <strong>di</strong> Chimica del Riconoscimento Molecolare, Via Mancinelli 7,<br />

20131 Milano, Italy. c KemoTech srl, Unità Operativa <strong>di</strong> Milano, Via Mancinelli 7, 20131 Milano,<br />

Italy. d C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o Neuroscienze<br />

PharmaNess S.c.a r.l.<br />

226. Anthocyani<strong>di</strong>ns modulate the cytotoxicity of irinotecan and oxaliplatin in human<br />

colon adenocarcinoma cells<br />

Cvorovic Jovana, Candussio L., Maestro A., Bartoli F., Decorti G.<br />

Department of Biome<strong>di</strong>cal Sciences, University of Trieste, Via Giorgieri 7, Trieste<br />

227. Preliminary results on antiproliferative effect of new deacetilase inhibitors on<br />

human leukemia cell lines<br />

Vitali Federica a , Turriziani M. b , D’Alfonso R. b , Lombardo M. b , Valenti S. c , Mai A. c , Tita B. a<br />

a Department of Human Physiology and Pharmacology, University of Rome “Sapienza”.<br />

b Department of Internal Me<strong>di</strong>cine, University of Rome “Tor Vergata”. c Department of<br />

Pharmaceutical <strong>Stu<strong>di</strong></strong>es, University of Rome “Sapienza”<br />

228. Topical administration of resveratrol as pre- and antineoplastic agent<br />

Berta Giovanni N., Mognetti B., Barberis A., Marinos L., Di Carlo F.<br />

Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Italy<br />

pag_sx.indd 1 30/05/2007 4.41.01


Farmacologia clinica e sperimentazione clinica dei farmaci<br />

Poster 229 – 239<br />

229. Effect of topiramate treatment in a patient affected ny symptomatic trigeminal<br />

neuralgia<br />

Gallelli Luca 1 , Siniscalchi A. 2 , Borner Perrone I. 1 , Davoli A. 1 , De Sarro G. 1<br />

1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Italy.<br />

2 Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy<br />

230. Pharmacokinetics of tramadol and of ITS metabolite N-desmethyltramadol in<br />

fasting and fed horses, after single oral administration<br />

Buti Deanna, Saccomanni G.*, Sgorbini M., Mengozzi G., Manera C.* Giorgi M.<br />

Departments of Veterinary Clinics V.le delle Piagge 2 56124 Pisa, Italy. *Pharmaceutical<br />

Science Via Bonanno 6 56126 Pisa, Italy<br />

231. Administration of oral sustained-release tablet formulation of tramadol in horses:<br />

pharmacokinetics of the parental drug and of n-desmethyltramadol<br />

Magnani Francesca, Saccomanni G.*, Casini L.**, Soldani G., Manera C.*, Giorgi M.<br />

Departments of Vetrinary Clinics V.le delle Piagge 2 56124 Pisa, *Pharmaceutical Science V.<br />

Bonanno 6 56126 Pisa and **Animal Productions, S. Piero a Grado, 56010 Pisa, Italy<br />

232. High homocysteine plasma levels in patients treated with antiepileptic drugs<br />

Gallelli Luca 2 , Liotti A. 2 , Siniscalchi A. 1 , Davoli A. 2 , Marigliano N.M. 2 , De Sarro G. 2<br />

1 Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy<br />

2 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Italy<br />

105<br />

233. Pharmakinetics of indomethacian in chronic migraine patients after withdrawal of<br />

the overused combination of indomethacin, prochlorperazine, and caffeine<br />

Ferrari Anna, Gallesi D., Sances G.*, Pinetti D., Bertolini A., Sternieri E.<br />

Toxicology and Clinical Pharmacology Section, Headache Centre, University Centre for<br />

Adaptive Disorders and Headache, Section Modena II. University of Modena and Reggio<br />

Emilia, Italy<br />

*Headache Unit, IRCCS C. Mon<strong>di</strong>no, University of Pavia, Italy<br />

234. Variability of oral sumatriptan pharmacokinetics in migraine patients<br />

Coccia Ciro, Pinetti D., Bertolini A., Sternieri E., Ferrari A.<br />

Toxicology and Clinical Pharmacology Section, Headache Centre, University Centre for<br />

Adaptive Disorders and Headache, Section Modena II. University of Modena and Reggio<br />

Emilia, Italy<br />

235. Hormonal index of well-being in women affected by me<strong>di</strong>cation overuse headache<br />

(MOH)<br />

Monnazzi Paola, Simeoni S., Martelletti P.* , Patacchioli F.<br />

Romana.<br />

Dept Human Physiology and Pharmacology “V. Erspamer”, *Internal Me<strong>di</strong>cine, 2 nd School of<br />

Me<strong>di</strong>cine, University of Rome La Sapienza, Italy<br />

pag_dx.indd 1 30/05/2007 4.47.44


236. Long-term efficacy of antihypertensive therapy in old-age patients with essential<br />

hypertension<br />

Sigala Sandra 1,2 , Alicandri C. 1 , Parini F. 1,2 , Valenti L. P. 1 , Parrinello G. 3 , Spano P.F. 2<br />

1 Division of Me<strong>di</strong>cine, Istituto Clinico Città <strong>di</strong> Brescia, Brescia, Italy; 2 Section of Pharmacology,<br />

Dept of Biomed Sci and Biotec, University of Brescia Me<strong>di</strong>cal School, Brescia, Italy; 3 Me<strong>di</strong>cal<br />

Statistic Unit, Dept of Biomed Sci and Biotec, University of Brescia Me<strong>di</strong>cal School, Brescia,<br />

Italy<br />

237. The role of CYP3A5 in methadone methabolism: a case report<br />

De Fazio Salvatore 1 , Scordo M.G. 2 , Gallelli L. 1 , Marigliano N.M. 1 , Ferreri Ibbadu G. 1 , Rende P. 1 ,<br />

De Sarro G. 1<br />

1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine, University of Catanzaro, Via T. Campanella 115, 88100 Catanzaro, Italy<br />

2 Department of Me<strong>di</strong>cal Sciences, Clinical Pharmacology; Uppsala University, Akademiska<br />

sjukhuset, Ing. 61, 75185 Uppsala, Sweden<br />

238. Management of lithium therapy during pregnancy<br />

Lampus Simona, Serio S., Chillotti C., Del Zompo M., Ardau R.<br />

Clinical Psychopharmacology Center, Section of Clinical Pharmacology, Department of<br />

Neurosciences "B. B. Bro<strong>di</strong>e", University of Cagliari<br />

106<br />

239. A new apomorphine formulation for oral administration<br />

Zara Gian Paolo 1 , Cattaldo S. 4 , Cavalli R. 2 , Calderoni S. 4 , Muntoni E. 1 , Gasco M.R. 5 , Mauro<br />

A. 3-4 , Ean<strong>di</strong> M. 1<br />

1 Dipartimento Anatomia Farmacologia e Me<strong>di</strong>cina Legale, 2 Dipartimento <strong>di</strong> Scienze e<br />

Tecnologia del Farmaco, 3 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> <strong>Torino</strong> Italy - 4 IRRCS<br />

Istituto Auxologico Italiano, Piancavallo Italy – 5 Nanovector s.r.l. <strong>Torino</strong> Italy<br />

Farmacovigilanza, farmacoepidemiologia e farmacoeconomia<br />

Poster 240 – 251<br />

240. Investigation on the opportunity in initiating treatment for hepatitis C virus (HCV)<br />

infection among drug users<br />

Mattioli Francesca, Montinaro E.*, Ducci E.*, Martelli A.<br />

Department of Internal Me<strong>di</strong>cine, Pharmacology Unit, University of Genoa, I-16132 Genoa,<br />

Italy<br />

*Valbisagno Drug Dependence Service (SerT) of Genoa<br />

241. Reports of adverse reactions to antibiotics in the Tuscan Pharmaresearch Database<br />

Tuccori Marco 1 , Montagnani S. 1 , Giustini Saffi E. 2 , Salvetti A. 2 , Blan<strong>di</strong>zzi C. 1 , Del Tacca M. 1<br />

1 Tuscan Regional Center for Pharmacovigilance - Division of Pharmacology and<br />

Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of Pisa – Pisa, Italy<br />

2 Italian Society of General Me<strong>di</strong>cine (SIMG) – Florence, Italy<br />

242. Retrospective evaluation of antidepressants side effects<br />

De Fazio Salvatore, Gareri P., Palleria C., Gallelli L., De Sarro G.<br />

Chair of Pharmacology, School of Me<strong>di</strong>cine, University “Magna Graecia” of Catanzaro, “Mater<br />

Domini” University Hospital, Via T. Campanella 115, 88100 Catanzaro, Italy<br />

243. Guidelines on the clinical use of clozapine<br />

Ligas Franca, Ardau R., Chillotti C., Del Zompo M.<br />

Clinical Psychopharmacology Centre, Section of Clinical Pharmacology, Department of<br />

Neurosciences “B.B. Bro<strong>di</strong>e”, University of Cagliari<br />

pag_sx.indd 1 30/05/2007 4.51.03


244. Observational study comparing the safety of typical and atypical antipsychotic drugs<br />

in patients affected by dementia with behavioural and psychological symptoms of<br />

dementia (BPSD)<br />

Capuano Annalisa, Potenza S., Ferrante L., Gallo M., Rinal<strong>di</strong> B., Filippelli A., Rossi F.<br />

Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “Leonardo Donatelli”. Center<br />

of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Me<strong>di</strong>cine and Surgery, Second<br />

University of Naples, Italy<br />

245. Prescribing pattern of Anti-Parkinson drugs in Southern Italy: cross-sectional<br />

analysis in the years 2003-5<br />

Trifirò Gianluca 1,5 , Savica R. 2 , Morgante L. 2 , Tari M. 3 , Moretti S. 3 , Vanacore N. 4 , Spina E. 1,5 ,<br />

Arcoraci V. 1 , Caputi A.C. 1,5<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Pharmacology Unit,<br />

University of Messina, Italy; 2 Department of Neuroscience, Psychiatry and Anaesthesiology,<br />

University of Messina, Italy; 3 Caserta-1 Local Health Service, Caserta – Italy; 4 National<br />

Centre for Epidemiology Surveillance and Health Promotion. National Institute of Health,<br />

Rome, Italy; 5 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy<br />

246. Use of herbal products in children: risks and benefits<br />

Loizzo Stefano 1,2 , Loizzo A.L. 3 , Capasso A. 4 , Loizzo A. 1<br />

1 Dept of Drug Research and Evaluation and 2 Dept of Cell Biology and Neurosciences, Istituto<br />

Superiore <strong>di</strong> Sanita’, Roma, Italy; 3 Dept of Pae<strong>di</strong>atric Neuropsychiatry, University of Roma Tor<br />

Vergata, Roma, Italy, 4 Dept of Pharmacology, University of Salerno, Salerno, Italy<br />

247. Knowledge and use of herbal drugs in pregnancy<br />

1 Micheli Lucia, 1 Nencini C., 1 Franchi G.G., 2 Urso R. 1, 2 , Giorgi G.<br />

1 Department of Pharmacology “Giorgio Segre”, University of Siena. 2 Centro Regionale <strong>di</strong><br />

Farmacovigilanza, Area Vasta Sud- Est (Siena), Regione Toscana<br />

107<br />

248. Drugs and herbal products in hospital practice: use and potential interactions<br />

Stocco Andrea 1 , Gallo U. 2 , Bano F. 2 , Bin A. 1 , Grion A. M. 2 , Ori C. 1 , Gaion R. M. 1 , Giron M.C. 1<br />

1 Department of Pharmacology and Anesthesiology, University of Padova. 2 Department of<br />

Pharmaceutical Care, ULSS 16 – Padova<br />

249. Knowledges about herbal products among subjects on warfarin therapy and<br />

patient-physician relationship<br />

Benoni Giuseppina 1 , Cuzzolin L. 1 , Francini-Pesenti F. 2 , Zaffani S. 1 , Brocadello F. 2 , Pengo V.<br />

3 , Bassi A. 4<br />

1 Department of Me<strong>di</strong>cine & Public Health-Section of Pharmacology, University of Verona,<br />

Italy; 2 Clinical Nutrition Unit, Hospital of Padua, Italy; 3 Clinical Car<strong>di</strong>ology-Thrombosis Centre,<br />

University of Padua, Italy; 4 Department of Clinical and Experimental Me<strong>di</strong>cine, University of<br />

Verona, Italy<br />

250. Attitudes, knowledge and use of herbal products among pregnant women: a pilot<br />

survey in Tuscany<br />

Vannacci Alfredo, Lapi F., Morsuillo M., Meschini M., Cipollini F. c , Di Pirro M., Cecchi E. a ,<br />

Banchelli G., Firenzuoli F., Mugelli A.<br />

Department of Preclinical and Clinical Pharmacology, University of Florence, Italy a Emergency<br />

Department, Prato Hospital, ASL 4, Italy; b Centre of Natural Me<strong>di</strong>cine, ASL 11, Empoli, Italy;<br />

c Department of Statistical Sciences, University of Florence, Italy<br />

251. Surveillance and information on herbal me<strong>di</strong>cines use of in pregnancy in the Sicily<br />

Region<br />

Pieratti Antonella¹, Calapai G.¹, Corsello S.², Mirabile M.², Fava G.¹, Caputi A. P.¹<br />

1)<br />

Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina.<br />

2) U.O.C. of Ginecology and Obstetrics, Hospital S.S. Salvatore, Paternò, Catania<br />

pag_dx.indd 1 30/05/2007 4.52.45


Tossicologia sperimentale e clinica<br />

Poster 252 – 265<br />

252. Neurochemical modulation and behavioural change after neonatal administration of<br />

pyrethroids in animal model<br />

Nasuti Cinzia Carla 1 , Gabbianelli R. 2 , Di Stefano A. 3 , Cantalamessa F. 1<br />

1 Department of Experimental Me<strong>di</strong>cine and Public, University of Camerino, 62032 Camerino<br />

(MC).<br />

2 Department of Biology M.C.A., University of Camerino, 62032 Camerino (MC).<br />

3 Department of Drug Science, University of “G. D’Annunzio”, 66100 Chieti (CH)<br />

253. Role of brain renin angiotensin system in the acute hypertensive response to<br />

intracerebroventricular cadmium<br />

Varoni M.Vittoria, Palomba D., Anania V., Demontis M.P.<br />

D.B.A - Division of Pharmacology, Faculty of Veterinary Me<strong>di</strong>cine – University of Sassari<br />

254. Cancer chemoprevention: manipulation of xenobiotic metabolizing enzymes by<br />

glucoraphasatin and glucoraphasatin and glucoraphenin found in Brassicaceae<br />

Bonamassa Barbara 1 , Barillari J. 2 , Canistro D. 1 , Pozzetti L. 1 , Sapone A. 1 , Iori R. 2 , Biagi G.L. 1<br />

, Paolini M. 1<br />

1 Department of Pharmacology, Molecular Toxicology Unit, Alma Mater <strong>Stu<strong>di</strong></strong>orum - University<br />

of Bologna, Via Irnerio 48 - 40126 Bologna, Italy. 2 Agricultural Research Council - Research<br />

Institute for Industrial Crops (CRA-ISCI), via Corticella 133, Bologna, Italy<br />

108<br />

255. Effects of PCB101, PCB118, PCB138 and PCB153 alone and in mixture in MCF-7<br />

breast cancer cells: possible mechanism of action<br />

Chiesara Enzo, Marabini L., Ra<strong>di</strong>ce S.<br />

Department of Pharmacology, Chemoterapy and Me<strong>di</strong>cal Toxicology “E. Trabucchi”, University<br />

of Milan, Via Vanvitelli 32, 20129, Milan<br />

256. Does acetylsalycilic acid interfere with liver <strong>di</strong>methylbenzanthracene (DMBA)-<br />

metabolism? Study in a rat model of DMBA-induced mammary carcinogenesis<br />

Racca Silvia 1 , Spaccamiglio A. 1 , Dacasto M. 2 , Carletti M. 2 , Nebbia C. 2 , Abbadessa G. 1 , Di Carlo<br />

F. 1<br />

1 Department of Clinical and Biological Sciences, University of Turin, Orbassano (TO);<br />

2 Department of Animal Pathology, Division of Pharmacology and Toxicology, University of<br />

Turin, Grugliasco (TO)<br />

257. Effect of isothiazolinones on redox omeostasis of rat erythrocytes<br />

* Frosali Simona, * Priora R., * Margaritis A., § Di Stefano A., * Di Giuseppe D., * Summa D., * Di<br />

Simplicio P.<br />

* Department of Neuroscience, Pharmacology Unit, University of Siena. § Department of<br />

Molecular Biology, University of Siena<br />

258. Verminoside and verbascoside from Kigelia Africana: cytotoxic and genotoxic effects<br />

in human lymphocytes<br />

Autore Giuseppina, Santoro A., Bianco G., Picerno P., Aquino R.P., Marzocco S., Gazzerro P.,<br />

Lioi M.B. 1 , Bifulco M.<br />

Dipartimento <strong>di</strong> Scienze Farmaceutiche, Università <strong>di</strong> Salerno, Fisciano Italy. 1 Dipartimento <strong>di</strong><br />

Scienze delle Produzioni Animali, Università della Basilicata, Potenza Italy<br />

259. DNA fragmentation in peripheral blood lymphocytes of patients with liver cirrhosis<br />

related to alcohol abuse or to hepatitis B or C viruses<br />

Grossi Sarah, Mattioli F., Manfre<strong>di</strong> V., Sumberaz A. * , Testino G. * , Martelli A.<br />

Department of internal Me<strong>di</strong>cine, Pharmacology Unit, University of Genoa, I-16132 Genoa,<br />

Italy. * Gastreoenterology Unit – St. Martino Hospital – Genoa<br />

pag_sx.indd 1 30/05/2007 4.58.11


260. Effects of DP7 on human and rat liver CYP-dependent activities: a kinetic study<br />

D’Elia Paolo, Dragoni S., De Matteis F., Valoti M., Kawase M., Shah A., Motohashi N., Molnar<br />

J., Sgaragli G.<br />

Dipartimento Scienze Biome<strong>di</strong>che, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena, via A. Moro 2, 53100 Siena<br />

261. Formation of DNA-damaging N-nitroso compounds from the interaction of calciumchannel<br />

blockers with nitrite<br />

Robbiano Luigi, Gosmar M., Martelli A.<br />

Department of Internal Me<strong>di</strong>cine, Pharmacology Unit, University of Genoa, I-16132 Genoa,<br />

Italy<br />

262. Low-level lead, cadmium and vana<strong>di</strong>um: "in vitro" evaluation of their genotoxic<br />

potential as influenced by copper, zinc or selenium<br />

Carmignani Marco, Volpe A.R., Cesare P., Aimola P.<br />

Section of Pharmacology and Toxicology, Department of Basic and Applied Biology, University<br />

of L’Aquila, Via Vetoio 2, 67010 Coppito (L’Aquila), Italy<br />

263. Inhibitory enzymatic activity of semicarbazide<br />

Mastrangelo Sabina 1 , Evandri M.G. 2 , Maranghi F. 3 , Mantovani A. 3 , Bolle P. 1<br />

1 Department of Human Physiology and Pharmacology, “Sapienza” University of Rome; 2 Italian<br />

Me<strong>di</strong>cines Agency, Rome; 3 Department of Food Safety and Veterinary Public Health, Italian<br />

National Health Institute, Rome<br />

264. In vitro effects of two over-the-counter bleaching poducts on gingival epithelium<br />

and dental restorative material<br />

Cimino F., Tomaino A., Speciale A., Cristiani M., Trombetta D., Saija A.<br />

1 Dept. Farmaco-Biologico, School of Pharmacy, University of Messina, Italy<br />

109<br />

265. Human umbilical cord-derived hematopoietic stem cells in cyto- and geno-toxicity<br />

stu<strong>di</strong>es: results with cadmium and chromium compounds<br />

Carmignani Marco, Aimola P., Cesare P., Orsini F., Volpe A.R.<br />

Section of Pharmacology and Toxicology, Department of Basic and Applied Biology, University<br />

of L’Aquila, Via Vetoio 2, 67010 Coppito (L’Aquila), Italy<br />

Farmacogenetica, farmacogenomica e terapia genica<br />

Poster 266 – 273<br />

266. Serotonin transporter 5HTTLPR polymorphism, clinical variants and symptom<br />

severity in patients with irritable bowel syndrome<br />

Ghisu Narcisa 1 , Colucci R. 1 , Bellini M. 2 , Rossi G. 3 , Blan<strong>di</strong>zzi C. 1 , Gori G.i 1 , Marchi S. 2 , Tonini<br />

M. 4 , Del Tacca M. 1<br />

1 Division of Pharmacology and Chemotherapy and 2 Gastrointestinal Unit, Department of<br />

Internal Me<strong>di</strong>cine, University of Pisa, Italy; 3 Institute of Clinical Physiology-C.N.R., Italy;<br />

4 Department of Physiological and Pharmacological Sciences, University of Pavia, Italy<br />

267. Adverse effects of azathioprine in pe<strong>di</strong>atric patients with inflammatory bowel<br />

<strong>di</strong>sease and multilocus genotypes of enzymes involved in the metabolism of<br />

thiopurines<br />

Stocco Gabriele 1,2 , Martelossi S. 1 , Barabino A. 3 , Decorti G. 2 , Bartoli F. 1 , Ventura A. 1<br />

1) University of Trieste, Department of Sciences of Reproduction and Development and<br />

I.R.C.C.S. “Burlo Garofolo” Trieste, Pe<strong>di</strong>atric Clinic – 2) University of Trieste, Department of<br />

Biome<strong>di</strong>cal Sciences – 3) I.R.C.C.S. “G. Gaslini”, Genova<br />

pag_dx.indd 1 30/05/2007 4.56.07


268. Corticosensitivity in inflammatory bowel <strong>di</strong>sease: role of glucocorticoid receptor<br />

polymorphisms<br />

De Iu<strong>di</strong>cibus S. 1, 2 , Stocco G. 1, 2 , Drigo I. 1, 2 , Norbedo S. 2 , Bartoli F. 1 , Decorti G. 1, 2 , Martelossi<br />

S. 2 , Ventura A. 2<br />

1 Department of Biome<strong>di</strong>cal Sciences, University of Trieste. 2 Department of Pae<strong>di</strong>atrics,<br />

I.R.C.C.S. Burlo Garofolo Trieste<br />

269. Evidence of an increase of the active metabolites of thiopurines induced by<br />

aminosalicylates in inflammatory bowel <strong>di</strong>sease<br />

Marino S. 1, 2 , Stocco G. 1, 2 , Pozzi E. 3 , Martelossi S. 2 , Lionetti P. 3 , Malusà N. 4 , Decorti G. 1, 2<br />

Bartoli F. 1 , Ventura A. 2<br />

1 Department of Biome<strong>di</strong>cal Sciences, University of Trieste. 2 Department of Pae<strong>di</strong>atrics,<br />

I.R.C.C.S. Burlo Garofolo Trieste. 3 Research Children’s Hospital ‘Meyer’, Florence.<br />

4 Department of Prevention, Azienda Sanitaria 1, Trieste<br />

270. Influence of thiopurine methyltransferase genotype and phenotype on adverse<br />

events and efficacy of azathioprine in rheumatologic and gastroenterologic patients<br />

Gori Giovanni 1 , Colucci R. 1 , Ghisu N. 1 , Fornai M. 1 , Tani C. 2 , Mosca M. 2 , Ceccarelli L. 3 , Blan<strong>di</strong>zzi<br />

C. 1 , Costa F. 3 , Marchi S. 3 , Bombar<strong>di</strong>eri S. 2 , Del Tacca M. 1<br />

1 Division of Pharmacology and Chemotherapy, 2 Gastroenterology Unit, and 3 Rheumatology<br />

Unit, Department of Internal Me<strong>di</strong>cine, University of Pisa, Pisa, Italy<br />

110<br />

271. Identification of mutations in HERG and KCNE2 genes associated with arrhythmia in<br />

patients treated with macrolides<br />

Pannacci Marilou 1 , Sullo N. 2 , Caronno A. 1 , Lucini V. 1 , Grosso S. 1 , Scaglione F. 1<br />

1 Department of Pharmacology, University of Milan, Milan, Italy. 2 Department of Experimental<br />

Me<strong>di</strong>cine- Section of Pharmacology, 2 nd University of Naples, Naples, Italy<br />

272. An allenic variant of Na+/Ca++ exchanger promoter region, A2689C, plays a role in<br />

<strong>di</strong>astolic blood pressure response to beta-blockers and <strong>di</strong>hydropyri<strong>di</strong>ne Ca ++<br />

antagonists treatment in hypertensive patients<br />

Trimarco Valentina*, Bellis A.**, Marino M.**, Gigante B.**, De Luca N.**, Trimarco B.**,<br />

Annunziato L.*, Di Renzo G.*<br />

*Division of Pharmacology, Dept. of Neuroscience, Federico II University of Naples, Naples,<br />

Italy. **Dept. of Car<strong>di</strong>ovascular and Immunological Sciences, Federico II University of<br />

Naples, Naples, Italy<br />

273. Distribution of CYP3A5 and MDR-1 single nucleotide polymorphisms in Caucasian<br />

liver transplant patients<br />

Provenzani Alessio 1 , Poma P. 2 , Labbozzetta M. 2 , Notarbartolo M. 2 , Di Stefano R. 1 , Triolo F. 3 ,<br />

Vizzini G. 4 , Gridelli B. 5 , D’Alessandro N. 2<br />

1 Department of Clinical Pharmacy - ISMETT, 2 Department of Pharmacological Sciences -<br />

Università <strong>di</strong> Palermo, 3 Regenerative Me<strong>di</strong>cine and Cell Therapy Unit - ISMETT, 4 Department<br />

of Me<strong>di</strong>cine - ISMETT, 5 Department of Abdominal Surgery and Transplantation - ISMETT<br />

Farmaci innovativi <strong>di</strong> origine biotecnologica<br />

Poster 274 – 282<br />

274. Prolonging the action of recombinant human growth hormone by monopegylation of<br />

muteins<br />

Caboi Francesca*, Bossi M.*, Crobu D.*, Cabras A.*, Scaramuzza S.*, Taylor G.*<br />

*Bio-Ker s.r.l. c/o Scientific and technologic Park of Sar<strong>di</strong>nia Polaris, Loc. Piscinamanna Pula<br />

(Cagliari)<br />

pag_sx.indd 1 30/05/2007 4.57.32


275. Novel G-CSF mutant for conjugation<br />

Salis Barbara, Caboi F., Pitzalis S., Maullu C., Sergi M., Sollai L., Taylor G.<br />

Bio-Ker s.r.l. c/o Scientific and technologic Park of Sar<strong>di</strong>nia Polaris, Loc. Piscinamanna Pula<br />

(Ca)<br />

276. New long lasting PEGylated-hGH<br />

Selis Fabio*, Scaramazza S.*, Contis M.*, Pasut G. + , Veronese F. + , Schrepfer R.*<br />

*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Padova,<br />

Dipartimento <strong>di</strong> Scienze Farmaceutiche<br />

277. Silica Microparticles for the controlled release of human growth hormone<br />

Sergi Mauro*, Morpurgo M. + , Selis F.*, Parisi L. + , Concas D.*, Marongiu C.*, Schrepfer R.*,<br />

Tonon G.*<br />

* Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA)<br />

+ Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Padova, Dipartimento <strong>di</strong> Scienze Farmaceutiche<br />

278. Inhibition of NF-kB activation by decoy ODN released from liposomes in activated<br />

macrophages<br />

De Stefano Daniela 1 , Maiuri M.C 1 ., Simeon V. 1 , De Rosa G. 2 , LaGuar<strong>di</strong>a V. 2 , Carnuccio R. 1<br />

1 Department of Experimental Pharmacology; 2 Department of Pharmaceutical Sciences;<br />

University of Naples “Federico II”, Via D. Montesano n 49, 80131 Naples, Italy<br />

279. Osteogenic <strong>di</strong>fferentiation of human a<strong>di</strong>pose-derived stem cells (hASC)<br />

De Girolamo L. 1;2 , Sartori M. 1 , Bastoni S. 3 , Brini A.T. 1<br />

1 Me<strong>di</strong>cal Pharmacology Department, Faculty of Me<strong>di</strong>cine, University of Milan.<br />

2 IRCCS Galeazzi Orthope<strong>di</strong>c Institute, Milan. 3 Orthope<strong>di</strong>c and Traumatological Institute,<br />

Faculty of Me<strong>di</strong>cine, University of Milan<br />

111<br />

280. In vitro effects of anti-inflammatory drugs incorporated in solid lipid nanoparticles<br />

on human peripheral mononuclear blood cells from IBD patients<br />

Serpe Loredana 1 , Canaparo R. 2 , Daperno M. 3 , Ean<strong>di</strong> M. 1 , Gasco M.R. 4 , Zara G.P. 1<br />

1 Department of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of <strong>Torino</strong>, <strong>Torino</strong>,<br />

2 Department of Clinical Pathophysiology, University of <strong>Torino</strong>, <strong>Torino</strong>, 3 Department of<br />

Gastroenterology, Mauriziano Hospital, <strong>Torino</strong>, 4 Nanovector s.r.l, <strong>Torino</strong><br />

281. PEGylation of Recombinant Human Granulocyte Colony-Stimulating Factor (r-h-G-<br />

CSF) produced in Escherichia coli: a new drug to overcome neutropenia<br />

Bonatesta Rosa Rita*, Caboi F.*, Sergi M.*, Sollai L.*, Onali P. + , Schrepfer R.* Tonon G.*<br />

*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Cagliari,<br />

Dipartimento <strong>di</strong> Neuroscienze<br />

282. EMEA and emerging therapies and technologies: activity of the Innovation Task<br />

Force<br />

De Lisa Roberto, Ranzani D., Brassart L., Moulon I., Papaluca Amati M.<br />

EMEA European Me<strong>di</strong>cines’ Agency<br />

Appropriatezza della prescrizione dei farmaci<br />

Poster 283<br />

283. In<strong>di</strong>pendent drug information and prescibing appropriateness: a chance for health<br />

professionals and patients<br />

Luppino Maria R. 1,3 , Alacqua M. 1,3 , Catania M.A. 1,3 , Fava G. 1,3 , Gentile M. 1,3 , Oteri A. 1,3 ,<br />

Polimeni G. 1,2,3 , Russo A. 1,3 , Aliferopulos H. 3 , Genovese R. 3 , Sgroi C. 3 , Silvestro A. 3 , Zangla<br />

A. 3 , Caputi A. P. 1,2,3<br />

1 University of Messina -<br />

2 IRCSS “Bonino-Pulejo”, Messina -<br />

3 Messina Provincial Drug<br />

Information Center<br />

pag_dx.indd 1 30/05/2007 4.59.24


Sessione Poster<br />

Recettori e meccanismi <strong>di</strong> trasduzione del segnale<br />

Poster 1-20<br />

13.00-15.00<br />

1. Pharmacological characterization of adenosine receptors in bovine chondrocytes<br />

Tosi A. 1 , Varani K. 1 , Vincenzi F. 1 , Gessi S. 1 , Merighi S. 1 , Fogli E. 1 , Sacchetto V. 1 , Simioni C. 1 ,<br />

De Mattei M. 2 , Caruso A. 2 , Borea P.A. 1<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Section; 2 Department of<br />

Morphology and Hystology, University of Ferrara, Italy<br />

2. Bin<strong>di</strong>ng thermodynamics at the human A 2B adenosine receptor<br />

Fogli Eleonora 1 , Gessi S. 1 , Varani K. 1 , Merighi S. 1 , Sacchetto V. 1 , Simioni C. 1 , Leung E. 2 ,<br />

Mac Lennan S. 2 , Borea P.A. 1<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Unit and Inter<strong>di</strong>sciplinary<br />

Center for the Study of Inflammation, University of Ferrara, Italy; 2 King Pharm. Research and<br />

Development, Inc., Cary, North Carolina.<br />

112<br />

3. Adenosine modulates vascular endothelial growth factor expression via hypoxiainducible<br />

factor-1 in human glioblastoma cells<br />

Sacchetto Valeria 1 , Merighi S. 1 , Benini A. 1 , Mirandola P. 2 , Gessi S. 1 , Varani K. 1 , Simioni C.1,<br />

Fogli E.1, Leung E. 3 , Mac Lennan S. 3 , Borea P.A. 1 .<br />

1 Dpt of Clin. and Exp. Med., Pharmacol. Unit and Inter<strong>di</strong>sciplinary Center for the Study of<br />

Inflammation, Univ. of Ferrara, Italy; 2 Dpt of Human Anat., Pharmacol. and For. Med., Univ.<br />

of Parma, Italy; 3 King Pharm. Research and Development, Inc., Cary, North Carolina.<br />

4. Activated presynaptic P2x 7 receptors function as calcium channels linked to<br />

exocytotic glutamate release<br />

Guarnieri Stefania 1 , Paluzzi P. 1 , Cervetto C. 1 , Alloisio S. 2 , Nobile M. 2 , Marcoli M.1, Maura G. 1 *<br />

1 Dep. Experimental Me<strong>di</strong>cine, Pharmcology and Toxicology Section; * Center of Exellence for<br />

Biome<strong>di</strong>cal Research, University of Genoa, Genoa, Italy; 2 CNR, Biophysic Intitute, Genoa, Italy<br />

5. Activated P2x 7 receptors allow calcium entry and glutamate exit: investigation on<br />

transfected HEK 293 cells<br />

Paluzzi Paola 1 , Cervetto C. 1 , Guarnieri S. 1 , Alloisio S. 2 , Nobile M. 2 , Marcoli M. 1 , Maura G. 1*<br />

1 Dep. Experimental Me<strong>di</strong>cine, Pharmcology and Toxicology Section; * Center of Exellence for<br />

Biome<strong>di</strong>cal Research, University of Genoa, Genoa, Italy; 2 CNR, Biophysic Intitute, Genoa,<br />

Italy<br />

6. Extracellular Mg 2+ modulates C-terminal tail dependent P2x 7 receptor functional<br />

properties<br />

Alloisio Susanna, Barbieri R., Bozzo L., Nobile M.<br />

Institute of Biophysics, CNR, Via De Marini, 6 – 16149 Genoa, Italy<br />

7. Arachidonic acid potentiates native and recombinant P2x 7 -me<strong>di</strong>ated ERK1/2, but<br />

not JNK and p38 phosphorylation in cultured cortical astrocytes and human<br />

embryonic kidney 293 cells<br />

Barbieri Raffaella 1 , Alloisio S. 1 , Ferroni S. 2 , Nobile M. 1<br />

1 Institute of Biophysics, CNR, 16149 Genoa, Italy; 2 Dept. of Human and General Physiology,<br />

University of Bologna, 40127 Bologna, Italy<br />

pag_sx.indd 1 30/05/2007 5.04.34


8. Purinergic facilitation of parasympathetic activity in isolated pig detrusor:<br />

involvement of prejunctional P2X 3 receptors<br />

D’Agostino G., Con<strong>di</strong>no A.M., Barbieri A., Tonini M*<br />

Department of Experimental and Applied Pharmacology, School of Pharmacy, University of<br />

Pavia, Via Taramelli 14, and * Department of Physiological and Pharmacological Sciences, P.za<br />

Botta 10, I-27100 Pavia, Italy<br />

9. Role of P2 purinergic receptors on ca1 neurotransmission of rat hippocampal slices<br />

Traini Chiara , Coppi E., Pugliese A. M., Pedata F.<br />

Department of Preclinical and Clinical Pharmacology, University of Florence,<br />

Viale Pieraccini 6, 50139 Florence, Italy<br />

10. Role of PKA in EGFR transactivation induced by PGE2 in A431 cells<br />

Terzuoli Erika, Finetti F., Ziche M.<br />

Laboratory of angiogenesis, Department of Molecular Biology, University of Sien<br />

11. Insulin-like growth factor i (IGF-I) induces human mu opioid receptor (MOR)<br />

expression in <strong>di</strong>fferentiated neurons: role of transcription factors rest and STAT3<br />

Be<strong>di</strong>ni Andrea, Di Toro R. , Spampinato S.<br />

Department of Pharmacology and Toxicology – University of Bologna Irnerio 48 – 40126<br />

Bologna – Italy<br />

12. Resistin induces vascular insulin resistance through an impairment of AKT/eNOS<br />

phosphorylations<br />

Di Pardo Alba°, Gentile M.T.°, Vecchione C.°, Marino G.°, Antenucci G.°, Maffei A.°,<br />

Lembo G.° #<br />

°Department of Angio-Car<strong>di</strong>o-Neurology, Neuromed Institute, Pozzilli (IS), and # Department<br />

of Experimental Me<strong>di</strong>cine, “La Sapienza” University of Rome<br />

113<br />

13. Interaction between Wnt pathway and orphan nuclear receptors<br />

Motolese Marta 1 , Orlando R. 1 , Caricasole A. 3 , Terstappen G. C. 3 , Melchiorri D. 1 , Nicoletti F.<br />

1,2 , Caruso A. 1<br />

1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”;<br />

2 I.N.M. Neuromed , Pozzilli; Italy; 3 Sienabiotech s.p.a. Siena<br />

14. Study of synthetic peptides derived from PKI55, a PKC modulator, in stimulated<br />

human neutrophils<br />

Falzarano Sofia 1 , Franceschetti L. 1 , Spisani S. 2 , Selvatici R. 1<br />

1 Department of Experimental and Diagnostic Me<strong>di</strong>cine, Section of Me<strong>di</strong>cal Genetics, University<br />

of Ferrara; 2 Department of Molecolar Biochemistry and Biology, University of Ferrara<br />

15. The thyroid <strong>di</strong>sruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane appears to be<br />

an uncompetitive inverse agonist for the thyrotropin receptor<br />

Rossi Mario, Donati E., Dimida A., Ferrarini E., Agretti P., Giorgi F., Corsini G.U., Pinchera<br />

A., Vitti P., Tonacchera M., Maggio R.<br />

Department of Neuroscience (M.R., E.D., F.G., G.U.C.) and Department of Endocrinology,<br />

Centre of Excellence for the Study of Damage to the Nervous and Endocrine Systems<br />

Produced by Environmental, Alimentary, and Pharmacological Agents, AmbiSEN (A.D., E.F.,<br />

P.A., A.P., P.V., M.T.), University of Pisa, Pisa, Department of Experimental Me<strong>di</strong>cine,<br />

University of L’Aquila, Italy<br />

pag_dx.indd 1 30/05/2007 5.05.19


16. Pharmacological characterisation of the urotensin-ii receptor ligands urantide and<br />

UFP-803 in CHO hUT cells<br />

Batuwangala Madura 1,3 , Camarda V. 1 , Marzola E. 2 , McDonald J. 3 , Lambert D. G. 3 , Ng L. 3 ,<br />

Guerrini R. 2 , Regoli D. 1 , Calo’ G. 1<br />

1 Dept. of Pharmacology and 2 Dept. of Pharmaceutical Sciences, University of Ferrara, 44100<br />

Ferrara, Italy. 3 Dept. of Car<strong>di</strong>ovascular Sciences, Division of Anaesthesia, Pharmacology and<br />

Therapeutics, University of Leicester, Leicester, LE2 7LX, UK<br />

17. Stimulation of ephrin B induces mo<strong>di</strong>fications of hippocampal synaptic plasticity in<br />

neonatal and adult rats<br />

Piccinin Sonia 1 , Cinque C. 1 , Calo’ L. 1 , Patanè M. 1 , Melchiorri D. 1 , Bashir Z. 3 , Eusebi F. 1,2. ,<br />

Nicoletti F. 1,2<br />

1 Department of Human Physiology and Pharmacology, University La Sapienza of Rome, Italy;<br />

2 I.N.M. Neuromed, Pozzilli, Italy; 3 MRC Centre for synaptic plasticity, Department of Anatomy,<br />

University of Bristol, UK<br />

18. PGE2 promotes egfr transactivation and squamous cell carcinoma growth by the<br />

NOS and ERK1/2 pathways<br />

Solito Raffaella, Ziche M., Morbidelli L.<br />

Section of Pharmacology, Department of Molecular Biology, University of Siena<br />

114<br />

19. Selective H3 receptor isoforms activate Akt/GSK axis and ERK in rat cortical<br />

neurons<br />

Mariottini Chiara 1 , Bongers G. 3 , Leurs R. 3 , Fossati S. 2 , Chiarugi A. 2 , Blan<strong>di</strong>na P. 2 , Passani<br />

M.B. 2<br />

1 Dipartimento <strong>di</strong> Fisiologia, V.le Morgagni 65, Firenze, Italy; 2 Dipartimento <strong>di</strong> Farmacologia<br />

Preclinica e Clinica, V.le Pieraccini 6, Firenze, Italy; 3 Department of Me<strong>di</strong>cinal Chemistry, Vrije<br />

Universiteit, Amsterdam, The Netherlands<br />

20. Nitric oxide/cGMP signaling pathway exerts tonic control on intraocular pressure<br />

(IOP) homeostasis in rabbits<br />

Bastia Elena, Guzzetta M., Bion<strong>di</strong> S., Impagnatiello F.<br />

Nicox Research Institute, Bresso, Milano, Italy<br />

I canali ionici ed i meccanismi <strong>di</strong> trasporto<br />

Poster 21 – 30<br />

21. The effects of acetazolamide on calcium activated k+ channels in skeletal muscle<br />

are me<strong>di</strong>ated by interaction with the alpha subunit<br />

Mele Antonietta 1 , Tricarico D. 1 , Latorre R. 2 , Torres Y. 2 , Conte Camerino D. 1<br />

1 Dept. of Pharmacobiology, Fac of Pharmacy,University of Bari, Bari Italy; 2 Centro de Estu<strong>di</strong>os<br />

Cientificos, Val<strong>di</strong>via, Chile<br />

22. Fluvastatin may induce a chronic reduction of the store operated calcium entry in<br />

striated fibres: an other brick in the wall of the hypolipedemic drugs' myotoxicity?<br />

Rolland Jean-Francois, Liantonio A., Conte Camerino D.<br />

Department Pharmaco-Biology, Faculty of Pharmacy, University of Bar<br />

23. Hydrophobicity of phenylalanine 1586 within the pore of the human Nav1.4 so<strong>di</strong>um<br />

channel is a determinant of local anesthetic bin<strong>di</strong>ng<br />

Desaphy Jean-François 1 , Dipalma A. 1 , Catalano A. 2 , Lentini G. 2 , Franchini C. 2 , Tortorella<br />

V. 2 , Conte Camerino D. 1<br />

1 Section of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University<br />

of Bari, Via Orabona 4 – campus, 70125 Bari, Italy; 2 Department of Me<strong>di</strong>cinal Chemistry,<br />

Faculty of Pharmacy, University of Bari<br />

pag_sx.indd 1 30/05/2007 5.06.32


24. Structural requirements of n-benzyl tocainide analogs for stereoselective and potent<br />

block of skeletal muscle so<strong>di</strong>um channels<br />

1 De Bellis Michela, 1 De Luca A., 2 Corbo F., 2 Muraglia M., 2 Franchini C., 2 Tortorella P., 1 Conte<br />

Camerino D.<br />

1 Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of<br />

Bari and 2 Department of Me<strong>di</strong>cal Chemistry, Faculty of Pharmacy University of Bari, Italy<br />

25. Cellular and subcellular localization of Na + -Ca 2+ exchanger (NCX) 1, 2 and 3 in<br />

central nervous system (CNS)<br />

Magi Simona 1 , Castaldo P. 1 , Salucci S. 3 , Gobbi P. 3 , Minelli A. 2 , Amoroso S. 1<br />

1 Section of Pharmacology, Department of Neuroscience, University “Politecnica delle Marche”,<br />

Ancona and Institute of 2 Physiological and 3 Morphological Sciences, University of Urbino “Carlo<br />

Bo”<br />

26. Transport of pyri<strong>di</strong>ne nucleotides across the plasma membrane in mammalian cells<br />

Ercolano Emanuela, Billington R. A, Condorelli F., Canonico P.L., Genazzani A.A.<br />

DiSCAFF, Università del Piemonte Orientale, Novara<br />

27. So<strong>di</strong>um calcium exchanger and so<strong>di</strong>um dependent glutamate transporters<br />

involvement in energy production, in rat heart<br />

1 Castaldo Pasqualina, 2 Rodolico G., 2 Piegari E., 1 Magi S., 1 Corcione E., 2 Berrino L., 1 Amoroso<br />

S.<br />

1 Section of Pharmacology, Department of Neuroscience, Università “Politecnica delle Marche”,<br />

Ancona; 2 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology, Second University<br />

of Naples<br />

28. Taurine prevents the <strong>di</strong>suse-associated alteration of soleus muscle calcium<br />

homeostasis in the hindlimb-unloaded rats<br />

Giannuzzi Viviana, Liantonio A., Desaphy Jean-François, Pierno S., Conte Camerino D.<br />

Section of Pharmacology, Dept. of Pharmacobiology, University of Bari, Italy<br />

115<br />

29. Evaluation of the effects of a combined chronic treatment with atorvastatin and<br />

fenofibrate on rat skeletal muscle: an ex vivo electrophysiological and<br />

cytofluorimetric study<br />

Cippone Valentina, Giannuzzi V., Pierno S., Liantonio A., Conte Camerino D.<br />

Dept. of Pharmacobiology, Section of Pharmacology, Faculty of Pharmacy, University of Bari,<br />

Italy<br />

30. Pharmacological targeting of renal clc-k chloride channels: ligands structural<br />

requirements and therapeutic potential<br />

Liantonio Antonella 1 , Picollo A. 2 , Babini E. 2 , De Bellis M. 1 , Fracchiolla G. 3 , Carbonara G. 3 ,<br />

Tortorella P. 3 , Pusch M.l 2 , Conte Camerino D. 1<br />

1 Section of Pharmacology, Dept. of Pharmacobiology, University of Bari, Italy; 2 Institute of<br />

Biophysic-CNR, Genova, Italy; 3 Dept. of Me<strong>di</strong>cinal Chemistry, University of Bari, Italy<br />

Controllo farmacologico dei processi <strong>di</strong> morte e proliferazione cellulare<br />

Poster 31 – 45<br />

31. Endocannabinoids contribute to the neuroprotective effects of mGlu1 receptor<br />

antagonists against post-ischemic neuronal death<br />

Landucci Elisa, Scartabelli T., Cozzi A., Mannaioni G., Moroni F., Pellegrini G.D.<br />

Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze, Viale Pieraccini 6,<br />

50139 Firenze<br />

pag_dx.indd 1 30/05/2007 5.07.23


32. Transforming growth factor-1 protects rat cortical neurons against early and late -<br />

amyloid toxicity<br />

Caraci Filippo 1 , Copani A. 1 , Battaglia G. 2 , Nicoletti F. 2,3 , Sortino M.A. 4<br />

1 Dept. of Pharmaceutical Sciences, University of Catania ; 2 I.N.M. Neuromed, Pozzilli, Italy,<br />

3 Dept. of Human Physiology and Pharmacology, University of Rome ‘‘La Sapienza’’; 4 Dept. of<br />

Experimental and Clinical Pharmacology, University of Catania<br />

33. -Amyloid effects in <strong>di</strong>fferentiation and death of neural progenitor cell-derived<br />

neurons<br />

Calafiore Marco 1 , Giuffrida M.L. 1 , Sortino M.A. 2 , Copani A 1<br />

1 Department of Pharmaceutical Sciences,<br />

2 Department of Experimental and Clinical<br />

Pharmacology, University of Catania, Catania.<br />

34. Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of<br />

ischemic tolerance<br />

Scartabelli Tania, Landucci E., Moroni F., Pellegrini G.D.<br />

Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze, Viale Pieraccini 6,<br />

50139 Firenze.<br />

116<br />

35. Regulation of autophagy by the inositol trisphosphate receptor<br />

Maiuri Maria Chiara 1,2 , Criollo A. 2 , Tasdemir E. 2 , Carnuccio R. 1 , Kroemer G. 2<br />

1 Department of Experimental Pharmacology, Faculty of Biotechnological Sciences, University<br />

of Naples “Federico II”, Via D. Montesano 49, 80135 Napoli, Italy; 2 INSERM U848, University<br />

“Paris Sud”, Institut G. Roussy, 39 rue C. Desmoulins, F-94805 Villejuif, France<br />

36. Peripheral neuropathies: apoptosis-preventing activity of Acetyl-L-Carnitine<br />

Di Cesare Mannelli Lorenzo*, Ghelar<strong>di</strong>ni C.*, Vivoli E.*, Toscano A. § , Bartolini A.*<br />

* University of Florence, Dept. of Preclinical and Clinical Pharmacology, Viale Pieraccini 6,<br />

50139, Florence, Italy; § University of Florence, Dept. of Anatomy Hystology and Forensic<br />

Me<strong>di</strong>cine, Viale Morgagni 85, 50139, Florence, Italy<br />

37. Effects of combination treatment with azidothymi<strong>di</strong>ne and pharmacological<br />

inhibitors of NF-kB on apoptotic cell death in uninfected or virus-infected<br />

transformed cell lines<br />

3,5 Macchi Beatrice, 1 Minutolo A. 2 Matteucci C. , 1 , Balestrieri E. 3 Ascolani A. 4 Mastino A.<br />

1 Department of Experimental Me<strong>di</strong>cine and Biochemical Science, University of Rome “Tor<br />

Vergata”, Rome;<br />

2 Institute of Neurobiology and Molecular Me<strong>di</strong>cine, C.N.R., Rome;<br />

3 Department of Neuroscience, University of Rome “Tor Vergata”, Rome; 4 Department of<br />

Microbiological, Genetic and Molecular Sciences, University of Messina, Messina. 5 IRCCS Santa<br />

Lucia Rome, Italy<br />

38. Modulation of Bcl-2 expression by gemcitabine and nimesulide in human pancreatic<br />

tumor cell lines<br />

Longoni Biancamaria, Giovannetti A,, Bertacca L, Navarra T. , Mosca F.<br />

Department of Oncology, Transplantation and Advanced Technologies in Me<strong>di</strong>cine, University<br />

of Pisa<br />

39. Protective effect of levetiracetam versus oxygen stress -induced cell death in PC12<br />

and in SH-SY5Y cell lines<br />

1 Ascolani Arianna, 2 Matteucci C., 2 Balestrieri E, 3 Caltagirone C., 1,3 Macchi B.<br />

1 Department of Neuroscience, University of Rome “Tor Vergata”, Rome, Italy. 2 Department of<br />

Experimental Me<strong>di</strong>cine and Biochemical Science, University of Rome “Tor Vergata”, Rome,<br />

Italy. 3 IRCCS S. Lucia Rome, Italy<br />

pag_sx.indd 1 30/05/2007 5.08.31


40. Role of reactive oxygen species (ROS) in the antiapoptotic effect of oxysterols on<br />

human umbilical vein endothelial cells (HUVEC)<br />

Poggiani Chiara, Agnoletto L., Cusinato F., Trevisi L., Luciani S.<br />

Department of Pharmacology and Anaestesiology, University of Padova<br />

41. Hydrogen peroxide-dependent ERK1/2 dephosphorylation me<strong>di</strong>ates toxicity via<br />

upstream inhibition of the survival signalling in U937 cells exposed to peroxynitrite<br />

Cerioni Liana, Cantoni O.<br />

Institute of Pharmacology and Pharmacognosy, University of Urbino “Carlo Bo”<br />

42. Subnormothermic machine perfusion reduces necrosis and apoptosis and improves<br />

energy status during preservation of steatotic rat livers: implications for<br />

transplantation<br />

1 Ferrigno Andrea, 2 Rizzo V., 3 Carlucci F., 3 Tabucchi A., 4 Boncompagni E., 1 Richelmi P., 5 Cillo U,<br />

4 Freitas I., 1 Vairetti M.<br />

1 Dept. Int. Med. and Therapeutics and 2 Dept. of Biochemistry, IRCCS San Matteo, Univ. of<br />

Pavia; 3 Dept. Int. Med., Univ. of Siena, 4 Dept. of Animal Biology and IGM-CNR, Univ. of Pavia,<br />

5 Dept. General Surgery, Univ. of Padua<br />

43. A pathogenetic hypothesis of Unverricht-Lundborg <strong>di</strong>sease onset and progression<br />

Buzzi Andrea b , Franceschetti S. a , Sancini G. a , Zucchini S. b , Para<strong>di</strong>so B. b , Magnaghi G. a ,<br />

Frassoni C. a , Chikhladze M. a , Avanzini G. a , Simonato M. b<br />

a Neurological Institute “C. Besta”, Milan, Italy; b University of Ferrara, Italy<br />

44. Antiapoptotic effects of green tea polyphenol epigallocatechin-3-gallate (EGCG) on<br />

ischemic injury of the rat retina<br />

Tamburella Alessandra, Leggio G.M., Drago F.<br />

Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy<br />

117<br />

45. Melanocortins improve wound healing in experimental burn injury<br />

Bazzani Carla 1 , Giuliani D. 1 , Mioni C. 1 , Galantucci M. 1 , Zaffe D. 2 , Minutoli L. 3 , Bitto A. 3 ,<br />

Botticelli A. R. 4 , Altavilla D. 3 , Squadrito F. 3 , Guarini S. 1<br />

1 Dept. Biome<strong>di</strong>cal Sciences, Sect. Pharmacology, and 2 Dept. Anatomy and Histology,<br />

University of Modena and Reggio Emilia; 3 Dept. Clinical Exp. Me<strong>di</strong>cine and Pharmacology,<br />

Sect. Pharmacology, University of Messina; 4 Dept. Human Pathology, University of Pavia<br />

Farmacologia della trasmissione sinaptica<br />

Poster 46 – 53<br />

46. Muscarinic control of parasympathetic activity in isolated porcine airways:<br />

involvement of M1/M2 muscarinic autoreceptors<br />

Con<strong>di</strong>no A.M., Barbieri A., Zonta F., D’Agostino G.<br />

Department of Experimental and Applied Pharmacology, School of Pharmacy, University of<br />

Pavia, Via Taramelli 14, I-27100 Pavia, Italy<br />

47. Hierarchical control of dopamine neuron-firing patterns by neuronal nicotinic<br />

receptors<br />

Mameli-Engvall Monica 1,2,3 , Evrard A. 2 , Pons S. 2 , Maskos U. 2 , Svensson H.T. 1 , Changeux J-P. 2 ,<br />

Faure P. 2<br />

1 Karolinska Institute, Dept. Physiology and Pharmacology, S-17177 Stockholm, Sweden;<br />

2 Institut Pasteur, Unité Récepteurs et Cognition, URA CNRS 2182, Paris Cedex 15, France ;<br />

3 EDX Diagnostics SPA, Sardegna Ricerche, Localita’ Piscinamanna, Ed.3, 09010 Pula, Italy<br />

pag_dx.indd 1 30/05/2007 5.09.24


48. The release of endocannabinoids in the CA1 hippocampal area is modulated by<br />

mGlu1 receptors: a patch clamp study<br />

Mannaioni Guido, Baccini G., Landucci E., Moroni F., Pellegrini G.D.<br />

Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze, Viale Pieraccini 6,<br />

50139 Firenze<br />

49. Evidence for a possible interaction between cannabinoid and serotonergic systems<br />

in modulating inhibitory synaptic transmission in basolateral amygdala<br />

Domenici M.R. 1 , Marsicano G. 2 , Azad S.C. 3 , Lutz B. 4 , Popoli P. 1 , Zieglgänsberger W. 3 , Rammes<br />

G. 3<br />

1 Dep. Drug Res and Evaluation, Istituto Superiore <strong>di</strong> Sanità, Rome, Italy ; 2 Centre de<br />

Recherche INSERM François Magen<strong>di</strong>e, Bordeaux, France; 3 Max-Planck Institut for Psychiatry,<br />

Munich, Germany; 4 Dep of Physiological Chemistry,Johannes Gutenberg University, Mainz,<br />

Germany<br />

50. Pharmacological characterization of a new non-imidazole histamine H 3 antagonist<br />

Flammini Lisa, Bertoni S., Saccani F., Ballabeni V., Impicciatore M., Barocelli E.<br />

Department of Applied Pharmacological, Biological and Chemical Sciences, University of<br />

Parma, V.le GP Usberti 27/a, Parma<br />

118<br />

51. Serotonin efflux from rat dorsal raphe nucleus slices: modulation by corticotropin<br />

releasing factor<br />

Marino Silvia, Nazzaro C., Siniscalchi A.<br />

Department of Clinical and Experimental Me<strong>di</strong>cine University of Ferrara Via Fossato <strong>di</strong><br />

Mortara, 17-19 44100 Ferrara<br />

52. Monoaminergic changes in locus coeruleus and dorsal raphe nucleus following<br />

noradrenaline depletion<br />

Macheda Teresa 1 , Cassano T. 1 , Morgese M.G. 1 , Trabace L. 1 , Cuomo V. 2 , Gobbi G. 3<br />

1 Department of Biome<strong>di</strong>cal Sciences, University of Foggia, Italy;<br />

2 Department of<br />

Pharmacology and General Physiology, University of Rome, ‘La Sapienza’, Italy; 3 Dept. of<br />

Psychiatry, McGill University, Montréal, Qc, Canada<br />

53. Functional proteomics of neuroplasticity-related signaling in a rat model of<br />

depression with gene-enviroment interaction<br />

Musazzi Laura 1 , Giambelli R. 1,2 , Tar<strong>di</strong>to D. 1 , Caffino L. 1 , El Khoury A. 3 , Mathé A. 3 , Racagni<br />

G. 1 , Popoli M. 1<br />

1 Center of Neuropharmacology-Department of Pharmacological Sciences, University of Milano,<br />

Italy; 2 Department of Experimental and Clinical Pharmacology, School of Me<strong>di</strong>cine, University<br />

of Catania, Catania (Italy); 3 Karolinska Institutet, Inst. of Clinical Neuroscience, Karolinska<br />

Hospital Hud<strong>di</strong>nge, Stockholm (Sweden)<br />

Farmacologia car<strong>di</strong>ovascolare<br />

Poster 54 – 72<br />

54. Endothelial cells response to polyethylene terephthalate surfaces activated by<br />

irra<strong>di</strong>ation<br />

Pezzatini Silvia 1 , Satriano C. 2 , Morbidelli L. 1 , Ziche M. 1<br />

1 Pharmacology section, Dept Molecular Biology, University of Siena, Via A. Moro 2, 53100<br />

Siena, Italy; 2 Laboratory for Molecular Surfaces and Nanotechnologies and CSGI, Dept. of<br />

Chemical Sciences, University of Catania, viale A. Doria 6, 95025 Catania, Italy<br />

55. Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4 (TIMP-4)<br />

favouring coronary endothelial cell motility<br />

Monti Martina, Donnini S., Morbidelli L., Ziche M.<br />

Laboratory of Angiogenesis, Department of Molecular Biology, University of Siena<br />

pag_sx.indd 1 30/05/2007 5.10.44


56. Ace inhibitor-induced angiogenesis in coronary endothelium is me<strong>di</strong>ated by<br />

Fibroblast growth factor-2<br />

Donnini Sandra, Giachetti A., Ziche M., Morbidelli L.<br />

Laboratory of Angiogenesis, Dept. Molecular Biology, University of Siena, Siena, Ital<br />

57. Membrane proteins involved in flavonoid transport in endothelial cells<br />

Maestro Alessandra , Terdoslavich M. , Petris G. , Passamonti S. , Decorti G. <br />

Department of Biome<strong>di</strong>cal Sciences and Department of Biochemistry, Biophysics and<br />

Chemistry of Macromolecules, University of Trieste, Trieste<br />

58. A nitric oxide releasing pravastatin derivative, NCX 6550, improves vascular<br />

response in human and hypertensive rat vessels<br />

Presotto C., Miglietta D., Olivieri R., Uzzo M., Vago T.*, Gelpi G. # , Monopoli A.<br />

Nicox Research Institute, Bresso, Milan, Italy; * Department of Endocrinology, University<br />

Hospital “L.Sacco”, Milan; # Division of Car<strong>di</strong>ovascular Surgery, “L.Sacco” Hospital, Milan<br />

59. Nebivolol induces nitric oxide productione in the heart<br />

Maffei A. 1 , Poulet R. 1 , Di Pardo A. 1 , Carangi R. 1 , Carullo P. 1 , Gentile M.T. 1 , Lembo G. 1,2<br />

1 IRCCS Neuromed, Pozzili (IS); 2 La Sapienza University, Rome<br />

60. Role of protein kinase C and Rho kinase in the rat-selective vasoconstrictor effect of<br />

normormide<br />

1 Cavalli Maurizio, 2 Papparella I., 2 Ceolotto G., 1 Bova S.<br />

1 Department of Pharmacology and Anesthesiology, University of Padova; 2 Department of<br />

Clinical and Experimental Me<strong>di</strong>cine, University of Padova<br />

61. Hydrogen sulphide involvement in vascular tone in <strong>di</strong>abetic rats<br />

D’Emmanuele <strong>di</strong> Villa Bianca Roberta, Sorrentino R., Miti<strong>di</strong>eri E., Sorrentino R.<br />

Department of Experimental Pharmacology, University of Naples Federico II<br />

119<br />

62. Hyperglycemia-me<strong>di</strong>ated overexpression of cyclooxygenase-2 (COX-2) participates<br />

in vascular hyporeactivity of streptozotocin-induced type I <strong>di</strong>abetes<br />

Tarquinio Mariela, Nacci C., De Bene<strong>di</strong>ctis L., Montagnani M.<br />

Department of Pharmacology and Human Physiology - Me<strong>di</strong>cal School - University of Bari,<br />

70124 Bari, ITALY<br />

63. Neutrophil-dependent cerebral oedema in normal and <strong>di</strong>abetic rat: role of<br />

transcellular synthesis of cysteinil leukotrienes<br />

Brivio Ivan, Buccellati C., Di Gennaro A., Folco G., Sala A.<br />

Center for Car<strong>di</strong>opulmonary Pharmacology, Dep. of Pharmacological Sciences, University of<br />

Milan<br />

64. Angiotensin ii involvement in remodelling of carotids subjected to pressure overload<br />

Bianco Giuseppe 1 , Miti<strong>di</strong>eri E. 2 , D’Emmanuele <strong>di</strong> Villa Bianca R. 2 , Pinto A. 1 , Autore G. 1 ,<br />

Sorrentino R. 2<br />

1 Dipartimento <strong>di</strong> Scienze Farmaceutiche, Università <strong>di</strong> Salerno, Salerno; 2 Dipartimento <strong>di</strong><br />

Farmacologia Sperimentale, Università <strong>di</strong> Napoli, Federico II<br />

65. Evaluation of the effect of two <strong>di</strong>fferent doses of aspirin in patients undergoing<br />

coronary artery bypass graft (CABG)<br />

Brambilla Marta 1 , Centenaro C. 2 , Tremoli E. 1,2 , Parolari A. 2 , Camera M. 1,2<br />

1 Dept. Pharmacological Sciences, University of Milan; 2 Centro Car<strong>di</strong>ologico Monzino IRCCS,<br />

Milan, Italy<br />

pag_dx.indd 1 30/05/2007 5.11.54


66. Polydeoxyribonucleotide (PDRN) increases vegf production and blood flow in an<br />

experimental model of hind limb ischemia in rats<br />

Fiumara Tiziana 1 , Polito F. 1 , Bitto A. 1 , Minutoli L. 1 , Di Stefano V. 1 , Altavilla D. 1 , Cattarini G. 2 ,<br />

Caputi A.P 1 , Squadrito F. 1<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina<br />

and 2 Mastelli srl, Sanremo, Italy<br />

67. Hydrogen sulfide (H 2 S) inhibits aggregation of human platelets<br />

Zagli Giovanni 1 , Patacchini R. 2 , Trevisani M. 1 , Abbate R. 1 , Cinotti S. 1 , Gensini GF. 1 , Masotti<br />

G. 1 , Geppetti P. 1<br />

1 Department of Critical Care Me<strong>di</strong>cine & Surgery, University of Florence, Florence, Italy;<br />

2 Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy<br />

68. SERCA2 pump expression and phosphorilated phospholamban in mechanicalinduced<br />

ventricular hypertrophy in rats<br />

Popolo Ada, Morello S., 1 D’Emmanuele <strong>di</strong> Villa Bianca R., Marzocco S., 1 Sorrentino R., Autore<br />

G., Pinto A.<br />

Department of Pharmaceutical Sciences, University of Salerno; 1 Department of Experimental<br />

Pharmacology, University of Napoli “Federico II”<br />

120<br />

69. Nitric oxide donors: anti-aggregating effects and mechanisms of inhibition of<br />

platelet aggregation<br />

Priora Raffaella, Margaritis A., Frosali S., Summa D., Di Giuseppe D., Di Simplicio P.<br />

Department of Neuroscience, Pharmacology Unit, University of Siena<br />

70. Effects of hyperbaric oxygen therapy on thrombocytopenia and platelet aggregation<br />

during an experimental model of multiple organ failure syndrome<br />

Donniacuo Maria 1 , Rinal<strong>di</strong> B. 2 , Capuano A. 2 , Liguori G. 2 , Imperatore F. 2 , Cuzzocrea S. 3 ,<br />

Filippelli A. 2 , Rossi F. 2<br />

1 Doctorate in Pharmacological Sciences and Respiratory Physiopathology, Second University of<br />

Naples, Italy; 2 Department of Experimental Me<strong>di</strong>cine and Excellence Center of Car<strong>di</strong>ovascular<br />

Disease, Second University of Naples, Italy; 3 Department of Clinical and Experimental<br />

Me<strong>di</strong>cine and Pharmacology, University of Messina, Italy<br />

71. Proximal and <strong>di</strong>stal effects of arteriotomy in rat carotids: an extensive microarray<br />

analysis of gene expression<br />

1 Finicelli Mauro, 1 Forte A., 4 De Luca P., 2 Santè P., 2 Quarto C., 3 Onorati F., 3 Renzulli A.,<br />

1 Galderisi U., 2 Cotrufo M., 1 Cipollaro M., 1 Cascino A., 1 Rossi F., 1 Berrino L.<br />

Dept. of 1 Exp. Me<strong>di</strong>cine and 2 Car<strong>di</strong>othoracic Sciences, Second University of Naples; 3 Unit of<br />

Car<strong>di</strong>ac Surgery, University Magna Graecia, Catanzaro; 4 BIOGEM S.c.a.r.l., Ariano Irpino<br />

72. Effect of carbon nanotubes on human platelets<br />

Russier Julie § , Togna A. R. § , Togna G. I § , Serafino A.*, Almairac R.**, Fiorito S. <br />

§ Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”;<br />

*Institute of Neurobiology and Molecular Me<strong>di</strong>cine, CNR, Rome; **Laboratoire des Colloides,<br />

Verres, et Nanomateriaux,CNRS - University of Montpellier II; Department of Experimental<br />

Me<strong>di</strong>cine University of Rome “La Sapienza” - CNR<br />

pag_sx.indd 1 01/06/2007 15.29.05


Farmaci per la riduzione del rischio car<strong>di</strong>ovascolare<br />

Poster 73 – 80<br />

73. Antiatherosclerotic properties of everolimus: in vitro and in vivo stu<strong>di</strong>es<br />

Corsini A., Bellosta S., Baetta R., Ferri N., Arnabol<strong>di</strong> L., Canavesi M., Pfister P.*,Granata A.,<br />

Dorent R.*<br />

Department of Pharmacological Sciences, University of Milan, Milan, Italy; *Novartis Pharma<br />

AG, Basel, Switzerland<br />

74. Infection and atherosclerosis: simvastatin lowers the risk of developing<br />

atherosclerosis by limiting coxsackievirus B infection and the expression of proinflammatory<br />

markers in human vascular endothelial cells<br />

Ferioli Elena*, Bottelli A.*, Armocida G.*, Conal<strong>di</strong> P.G.°<br />

*Department of Me<strong>di</strong>cine and Public Health, University of Insubria, Varese, Italy; °ISMETT,<br />

Palermo, Italy<br />

75. In vivo stimulation of LXR increases the efflux potential of sera and promotes the<br />

reverse cholesterol transport<br />

Zanotti Ilaria, Potì F., Pedrelli M., Favari E., Calabresi L.*, Moleri E.*, Bernini F.<br />

Dept. of Pharmacological and Biological Sciences and Applied Chemistries, University of<br />

Parma, Parma, and *Center E. Grossi Paoletti, Dept. of Pharmacological Sciences, University<br />

of Milan, Milan<br />

76. Role of mesna to reduce homocysteine levels through SH/SS exchange reaction:<br />

possible therapeutical applications in hyperhomocysteinemic patients<br />

Di Giuseppe Daniele, Frosali S., Priora R., Margaritis A., Summa D., Di Simplicio P.<br />

Department of Neuroscience, Pharmacology Unit, University of Siena<br />

121<br />

77. Protein-thiol substitution or protein dethiolation by SH/SS echange reactions: the<br />

albumin model<br />

Di Simplicio Paolo, Summa D., Ottavia S., Priora R., Frosali S., Margaritis A., Di Giuseppe D.,<br />

Niccolai N.<br />

Department of Neuroscience, Pharmacology Unit, and Dept of Molecular Biology, University of<br />

Siena, 53100 Siena, Italy; *Department of Molecular Biology, University of Siena, 53100<br />

Siena, Italy<br />

78. Flaxseed oil supplementation increases plasma and tissue concentrations of ( -3)<br />

fatty acids in rats<br />

Notarangelo Francesca § , Avallone R. § , Rustichelli C. # , Campioli E. § , Braghiroli D. # , Baral<strong>di</strong> M. §°<br />

§ Department of Biome<strong>di</strong>cal Sciences, # Department of Pharmaceutical Sciences, Via Campi<br />

287, 41100 Modena, Italy, Pharmacology, °National InterUniversity Consortium for the Study<br />

of Natural Active Principles (CINSPAN)<br />

79. Synthesis and preliminary biological evaluation of new partially fluorinated thiol<br />

dual inhibitors of neutral endopeptidase 24.11 and angiotensin converting enzyme<br />

Tambaro Simone a , Olimpieri F. b , Lazzari P. a , Volonterio A. b , Pittau B. a , Pani L. a,c , Zanda M b<br />

a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />

(CA), Italy; b C.N.R. Istituto <strong>di</strong> Chimica del Riconoscimento Molecolare, Via Mancinelli 7,<br />

20131 Milano, Italy; d C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o<br />

Neuroscienze PharmaNess S.c.a r.l.<br />

80. Car<strong>di</strong>oprotective activity of sidenafil in rats with chronic nitric oxide synthase<br />

inhibition<br />

Manfre<strong>di</strong> Barbara, De Gennaro Colonna V., Berti F., Rossoni G.<br />

Department of Pharmacology, Chemotherapy and Me<strong>di</strong>cal Toxicology, University of Milan,<br />

Italy<br />

pag_dx.indd 1 30/05/2007 5.15.49


Farmacologia del sistema nervoso<br />

Poster 81 – 110<br />

81. Nociceptin/Orphanin FQ-induced inhibition of electrical activity in dorsal raphe<br />

nucleus slices from normal and stressed rats<br />

Siniscalchi Anna, Barbieri M., Nazzaro C., Beani L.<br />

Department of Clinical and Experimental Me<strong>di</strong>cine University of Ferrara, Via Fossato <strong>di</strong><br />

Mortara, 17-19; 44100 Ferrara<br />

82. Pharmacological characterization of the Nociceptin/Orphaninn FQ receptor<br />

antagonist SB-612111: in vivo stu<strong>di</strong>es<br />

1 Rizzi Anna, 1 Gavioli E., 1 Marzola G., 1 Spagnolo B., 1 Zucchini S., 2 Ciccocioppo R., 3 Trapella C.,<br />

1 Regoli D., 1 Calo’ G.<br />

1 Dept. of Pharmacology and 3 Dept of Pharmaceutical Science, University of Ferrara, Italy;<br />

2 Dept. of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy<br />

83. Functional antagonism between Nociceptin/Orphanin FQ (N/OFQ) and CRF in the<br />

rat brain: evidence for involvement of the bed nucleus of the stria terminalis<br />

Ro<strong>di</strong> Donata (1) , Zucchini S. (1) , Simonato M. (1) , Cifani C. (2) , Massi M. (2) , Polidori C. (2)<br />

1)<br />

Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Section, and Neuroscience<br />

Centre, University of Ferrara; 2) Department of Experimental Me<strong>di</strong>cine and Publich Health,<br />

University of Camerino<br />

122<br />

84. Anticonvulsant effects of orphanin FQ on seizures induced by pentylenetetrazole<br />

Di Giannuario Amalia 1 , Colucci M. 1 , Maione F. 1,2 , Mascolo N. 2 , Pieretti S. 1<br />

1 Department of Drug Research and Evaluation, Istituto Superiore <strong>di</strong> Sanità, V.le Regina Elena<br />

299 - 00161 Rome. 2 Department of Experimental Pharmacology, University of Naples Federico<br />

II, Via Domenico Montesano 49 - 80131 Naples<br />

85. Effect of novel Nociceptin/Orphanin FQ-NOP receptor ligands on food intake in<br />

wistar rats<br />

Cifani Carlo a , Polidori C. a , Calò G. b , Massi M. a<br />

a Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, I-62032,<br />

Camerino, Italy; b Department of Experimental and Clinical Me<strong>di</strong>cine, Section of Pharmacology<br />

and Neuroscience Center, University of Ferrara, I-44100 Ferrara, Italy<br />

86. Chronic i.c.v. Treatment with [Nphe 1 , Arg 14 , Lys 15 ] N/OFQ-NH 2 (UFP-101), a potent<br />

nop receptor antagonist, reverses behavioural and biochemical effects of chronic<br />

mild stress in rats<br />

Vitale Giovanni a , Ruggieri V. a , Frigeri C. a , Filaferro M. a , Guerrini R. b , Massi M. c<br />

a Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, University of Modena and<br />

Reggio Emilia; b Department of Pharmaceutical Sciences , University of Ferrara; c Department<br />

of Pharmacological Sciences and Experimental Me<strong>di</strong>cine, University of Camerino<br />

87. Nociceptin/Orphanin FQ and food intake in <strong>di</strong>sease-prone WOKW and <strong>di</strong>seaseresistant<br />

DA rats<br />

a Cifani Carlo, a Filippetti R., b Kloting I., a Massi M., a Polidori C.<br />

a Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, I-62032<br />

Camerino, Italy - b Department of Laboratory Animal Science, Me<strong>di</strong>cal Faculty, University of<br />

Greifswald, D-17495 Karlsburg, Germany<br />

pag_sx.indd 1 30/05/2007 5.36.18


88. The neuro<strong>di</strong>fferentiative effect of estrogen involves nuclear receptors and is<br />

me<strong>di</strong>ated by TGF-<br />

Merlo Sara 1,2 , Canonico P.L. 2 , Copani A. 3 , Sortino M.A. 1<br />

Departments of 1 Experimental and Clinical Pharmacology and 3 Pharmaceutical Sciences,<br />

University of Catania, and 2 DISCAFF, University of Piemonte Orientale, Novara<br />

89. Erythropoietin inhibts the release, but not synthesis, of corticotropin-releasing<br />

hormone from rat hypothalamic explants in vitro<br />

Tringali Giuseppe, Lisi L., Pozzoli G., Navarra P.<br />

Institute of Pharmacology, Catholic University Me<strong>di</strong>cal School, Rome, Italy<br />

90. Neurochemical effects of post-weaning social isolation in adult rat brain<br />

Colaianna Marilena (a) , De Giorgi A. (a) , Cuomo V. (b) , Trabace L. (a)<br />

(a) Dept. Biome<strong>di</strong>cal Sciences, University of Foggia, Foggia, Italy; (b) Dept. of Human Physiology<br />

and Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy<br />

91. Strain-dependent levels of biogenic amine in post-weaning socially-isolated rats<br />

Castrignanò Silvia (a) , Zotti M. (a) , Cuomo V. (b) , Trabace L. (a)<br />

(a) Dept. of Biome<strong>di</strong>cal Sciences, University of Foggia; (b) Dept. of Human Physiology and<br />

Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy<br />

92. Selective volume reduction of anterior cingulate cortex in young adult rats after<br />

neonatal excitotoxic lesion of ventral hippocampus<br />

Casu Gianluca * , Marchese G. * , Casti P. * , Pinna Spada G. * , Pani L. *<br />

§* Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />

(CA), Italy; § C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o Neuroscienze<br />

PharmaNess S.c.a r.l.<br />

123<br />

93. Acute but not chronic treatment with olanzapine reduces experimental anxiety in<br />

rats: possible mechanisms<br />

Locchi Federica, Rimon<strong>di</strong>ni R., Dall’Olio R., Gandolfi O.<br />

Department of Pharmacology, University of Bologna, 40128 Bologna, Italy<br />

94. Gender <strong>di</strong>fferences on long term effects of rat prenatal stress on dorsal and ventral<br />

hippocampal metabotropic glutamate receptors and anxiety behaviour<br />

Zuena Anna Rita 1,2 , Casolini P. 1 , Mairesse J. 1,2 , Cinque C. 1 , Matteucci P. 1 , Alemà G.S. 1 , Morley-<br />

Fletcher S. 2 , Catalani A. 1 , Nicoletti F. 1,3 , Maccari S. 2<br />

1 Dept of Human Physiology and Pharmacology, Univesity of Rome “La Sapienza”, Italy; 2 Lab<br />

of Perinatal Stress, University of Lille 1, France; 3 INM Neuromed, Pozzilli, Italy<br />

95. Post-natal repeated mild stress induces changes in brain NAD(P)H recycling in adult<br />

male mice: role of the opioid system<br />

Loizzo Stefano, Guarino I., Galietta G., Fortuna A., Loizzo A., Spampinato S., Campana G.,<br />

Capasso A., Franconi F.<br />

Section of Drugs and Health for the Child and the Woman, Dept of Drug Research and<br />

Evaluation, and National Centre for Rare Diseases, Istituto Superiore <strong>di</strong> Sanita’, Roma, Dept<br />

of Pharmacology, University of Bologna, Dept of Pharmacology, University of Salerno, Dept of<br />

Pharmacology and Centre of Excellence for Biotechnology and Bio<strong>di</strong>versity University of<br />

Sassari, and GIOIA Foundation<br />

96. Changes in hippocampal gene expression profile following acute and chronic stress<br />

in the mouse<br />

Ubal<strong>di</strong> Massimo 1 , Lourdusamy A. 1 , Soverchia L. 1 , Cippitelli A. 1 , Ruggeri B. 1 , Har<strong>di</strong>man G. 2 ,<br />

Ciccocioppo R. 1<br />

1 Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino Italy;<br />

2 Department of Me<strong>di</strong>cine, University of California San Diego, CA, USA<br />

pag_dx.indd 1 30/05/2007 5.33.54


97. Treatment of premenstrual syndrome with continuous low dosage sertralin<br />

Tammaro Emanuela*, Milano W., Milano L., Rundle-Smith S., Petrella C., Capasso A.*<br />

Mental Health Operations Unit District 44 ASL Napoli 1 and *Department of Pharmaceutical<br />

Sciences, University of Salerno, Italy<br />

98. Novel therapeutic opportunities in unipolar depression<br />

Corsi Mauro, W.P.<br />

Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithkline S.p.A., Verona, Italy<br />

99. Lifestyle interventions on bodyweight gain olanzapine-induced: result from a<br />

randomized-controlled trial<br />

Cammarano Michela*, Milano W., Comazzi M.°, Milano L., Petrella C., Capasso A.*<br />

Unità Operativa Salute Mentale Distretto 44 ASL Napoli1; * Department of Pharmaceutical<br />

Sciences, University of Salerno, Italy; ° Unità <strong>di</strong> Psichiatria Azienda Ospedaliera <strong>di</strong> Melegnano<br />

Milano<br />

124<br />

100. Tolerability of antipsychotics in children and adolescents: a prospective study<br />

Alacqua Marianna 1 , Trifirò G. 1,4 , Arcoraci V. 1 , Germanò E. 2 , Gagliano A. 2 , Siracusano M. 2 , Di<br />

Vita G. 3 , Gagliano C. 3 , Spina E. 1, 4<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Pharmacology Unit,<br />

University of Messina, Italy - 2 Division of Child Neurology and Psychiatry, University of<br />

Messina, Italy - 3 Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS),<br />

Troina, Italy; 4 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy<br />

101. Plasma concentrations of quetiapine during coadministration with antiepileptic<br />

drugs in psychiatric patients<br />

D’Arrigo Concetta 1 , Migliar<strong>di</strong> G. 1 , Santoro V. 2 , Muscatello M.R. 3 , Zoccali R. 3 , Spina E 1,2<br />

1 Section of Pharmacology, Department of Clinical and Experimental Me<strong>di</strong>cine and<br />

Pharmacology, 2 IRCCS Centro Neurolesi “Bonino-Pulejo” and 3 Department of Neurosciences,<br />

Psychiatric and Anesthesiological Sciences, University of Messina, Messina, Italy<br />

102. Potential application of testosterone metabolites in the treatment of<br />

adrenoleukodystrophy<br />

Carissimi Romina 1 , Blasevich M. 1 , Cappa M. 2 , Uziel G. 3, Petroni A. 1<br />

1 Depart. of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan, Italy;<br />

2 Depart. of Pe<strong>di</strong>atrics Me<strong>di</strong>cine, Children’s Hospital “Bambino Gesù”, IRCCS, Rome, Italy;<br />

3 Child Neurology Dep., Istituto Neurologico “C. Besta”, Milan, Italy<br />

103. Development of specific biomarkers for als clinical progression: validation and<br />

potential roles in pathogenesis<br />

Bonini Sara A. 1 , Zhao Z. 2 , Lange D. J 3 ., Ho L. 2 , Yemul S. 2 , Wang J. 2 , Salton S. 4 , Memo M. 1 ,<br />

Pasinetti G.M. 2<br />

1 Department of Biome<strong>di</strong>cal Sciences and Biotechnologies, University of Brescia, Brescia, Italy;<br />

2 Department of Psychiatry, 3 Department of Neurology, 4 Department of Neuroscience, Mount<br />

Sinai School of Me<strong>di</strong>cine, New York, New York, USA<br />

pag_sx.indd 1 30/05/2007 5.37.18


104. Functional heterogeneity of histaminergic neurons suggest interesting applications<br />

of GSK189254, a novel H 3 receptor antagonist<br />

Giannoni Patrizia 1 , Passani M.B. 1 , Nosi D. 2 , Medhurst A.D. 3 , Chazot P. 4 , Shenton F. 4 ,<br />

Blan<strong>di</strong>na P. 1<br />

1 Dipartimento <strong>di</strong> Farmacologia Preclinica and Clinica, 2 Dipartimento <strong>di</strong> Anatomy Universita’ <strong>di</strong><br />

Firenze Italy, 3 Neurology Centre of Excellence for Drug Discovery,GlaxoSmithKline,Essex<br />

CM19 5AW, UK, 4 Centre for Integrative Neuroscience, School of Biological and Biome<strong>di</strong>cal<br />

Sciences, Durham University, UK<br />

105. Improvements in long-term memory retention by inhibition of fatty acid amide<br />

hydrolase (FAAH) are me<strong>di</strong>ated by -type peroxisone proliferator-activated<br />

receptors (PPAR) And not by cannabinoid CB 1 receptors<br />

Mazzola C 1 , Medalie J. 1 , Panlilio L.V. 1 , Solinas M. 2 , Drago F. 3 , Goldberg S.R. 1 , Yasar S. 4<br />

1 Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural<br />

Research Program, NIDA, NIH, DHHS, Baltimore, MD, 21224, USA. 2 Department Laboratoire<br />

de Biologie et Physiologie Cellulaires, CNRS-6187, Université de Poitiers, 86022, Poitiers,<br />

France. 3 Department of Experimental and Clinical Pharmacology, Me<strong>di</strong>cal School, University of<br />

Catania, Italy. 4 Division of Geriatric Me<strong>di</strong>cine, Johns Hopkins Me<strong>di</strong>cal School, Baltimore, MD,<br />

21224, USA<br />

106. Tricyclic pyrazoles. Synthesis and biological evaluation of novel 4,5-<strong>di</strong>hydro-1H-6-<br />

oxa-cyclohepta[1,2-c]pyrazole-based analogues of cannabinoid antagonist NESS<br />

0327<br />

Dessì Christian ‡ , Murineddu G. † , Ruiu S. ‡ , Loriga G. † , Manca I. † , Lazzari P. ‡ , Pau A. † ,<br />

Reali R. ‡ , Pinna G.A. † , Pani L. ‡,§<br />

‡ Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />

(CA), Italy; † Dipartimento Farmaco Chimico Tossicologico, Università <strong>di</strong> Sassari, Via F. Muroni<br />

23/A, 07100 Sassari, Italy; § C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o<br />

Neuroscienze PharmaNess S.c.a r.l.<br />

125<br />

107. Early and late post-mortem neural stem cells grow and <strong>di</strong>fferentiate in vitro. A novel<br />

source for cellular therapy<br />

Madaschi Laura 1* , Marfia G. 1* , Cigognini D. 1 , Bottai D. 1,2 , Di Giulio A.M. 1 , Gorio A. 1,2<br />

1) Dept. of Me<strong>di</strong>cine, Surgery and Dentistry, Faculty of Me<strong>di</strong>cine, University of Milan, Italy;<br />

2) Clinical Pharmacology IRCCS Humanitas, Milan, Italy; *These two authors equally<br />

contributed at this work<br />

108. Calcineurin primes GnRH-secreting neurons for migration<br />

Zaninetti Roberta, Tacchi S., Erriquez J., Distasi C., Maggi R.*, Canonico P.L., Genazzani A.A.<br />

Dipartimento <strong>di</strong> Scienze Chimiche, Alimentari, Farmaceutiche Farmacologiche, Drug and Food<br />

Biotechnology Center, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> del Piemonte Orientale “A. Avogadro”, Novara<br />

*Laboratorio <strong>di</strong> Neuroendocrinologia dello Sviluppo, Istituto <strong>di</strong> Endocrinologia, CEND,<br />

Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano<br />

109. Peptide-derivatized nanoparticles as carriers of drugs into the central nervous<br />

system<br />

Tacchi Raffaella 1 , Vergoni A.V. 3 , Tosi G. 4 , Costantino L. 4 , Rivasi F. 2 , Bertolini A. 1 , Ruozi B. 4 ,<br />

Forni F. 4 , Vandelli M.A. 4<br />

Departments of: Diagnostic and Laboratory Services, Section of Clinical Pharmacology 1 and<br />

Section of Pathological Anatomy 2 ; Biome<strong>di</strong>cal Sciences, Section of Pharmacology 3 ;<br />

Pharmaceutical Sciences 4 ; University of Modena and Reggio Emilia<br />

110. Standar<strong>di</strong>zed analysis of c-fos mRNA expression pattern in rat brain<br />

autora<strong>di</strong>ography using freeware imaging software<br />

Dipasquale Pasqua, Celentano M., Righetti L., Lucchino I., Gaetani S., Cuomo V.<br />

Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”<br />

pag_dx.indd 1 30/05/2007 5.42.56


Farmacologia dei processi degenerativi<br />

Poster 111 – 132<br />

111. GPR17: a new dual receptor for both extracellular nucleotides and cysteinylleucotrienes<br />

involved in brain ischemia<br />

Gelosa Paolo 1 , Sironi L.i 1 , Guerrini U. 1 , Tremoli E. 1,2 , Enrico R. 1 , Patrizia Rosa 3 , Lecca D. 1 ,<br />

Pignieri A. 1 , Abbracchio M. P 1* , Cimino M. 4*<br />

1 Department of Pharmacological Sciences, University of Milan, Italy - 2 Monzino Car<strong>di</strong>ologic<br />

Centre IRCCS, Milan, Italy - 3 CNR Institute of Neuroscience, Cellular and Molecular<br />

Pharmacology, Milan, Italy - 4 Institute of Pharmacology and Pharmacognosy, University of<br />

Urbino, Italy; *equally contributed to the present work<br />

112. Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampus<br />

Russo E. 1 , Donato G. 1 , De Fazio S. 1 , De Fazio P. 1 , Perrotta I. 2 , De Sarro G. 1<br />

1 Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery,<br />

University of Catanzaro, Catanzaro, Italy; 2 Ecology Department, University of Calabria,<br />

Cosenza, Italy.<br />

126<br />

113. Blunted HPA axis activity during ischemia protects adult rats neonatally exposed to<br />

glucocorticoids against brain damage<br />

Cinque Carlo 1 , Mairesse J. 3 , Casolini P. 1 , Domenici M. R. 2 , Galluzzo M. 2 , Musumeci M. 2 , Alemà<br />

G. S. 1 , Zuena A. R. 1 , Matteucci P. 1 , Maccari S. 3 , Nicoletti F. 1,4 , Catalani A. 1<br />

1. Dep. of Human Physiol & Pharmacol, University “Sapienza”, Rome, Italy; 2. Dep. of<br />

Pharmacol, Istituto Superiore <strong>di</strong> Sanità, Rome, Italy; 3. Lab. Perinatal Stress, JE2365.<br />

University of Lille 1, 59655 Villeneuve d’Ascq, France; 4. INM Neuromed, Pozzilli, Italy<br />

114. Knocking-down and knocking-out of NCKX2 gene expression exacerbate the brain<br />

insult induced by focal ischemia<br />

Cuomo Ornella, Pignataro G., Gala R., Boscia F., Tortiglione A., Valsecchi V., Di Renzo GF.,<br />

Lytton J.* , Annunziato L.<br />

Division of Pharmacology, Department of Neuroscience, School of Me<strong>di</strong>cine, , Federico II<br />

University of Naples, Via S. Pansini 5, 80131 Naples, Italy. *Department of Biochemistry and<br />

Molecular Biology University of Calgary, Calgary, Alberta, Canada<br />

115. Neuroprotective effect of melanocortins in focal cerebral ischemia<br />

Giuliani Daniela 1 , Ottani A. 1 , Mioni C. 1 , Galantucci M. 1 , Bazzani C. 1 , Zaffe D. 2 , Bitto A. 3 ,<br />

Minutoli L. 3 , Botticelli A. R. 4 , Altavilla D. 3 , Squadrito F. 3 , Guarini S. 1<br />

1 Dept. Biome<strong>di</strong>cal Sci., Sect. Pharmacology, and 2 Dept. Anatomy and Histology, University of<br />

Modena and Reggio Emilia; 3 Dept. Clin. Exp. Med. Pharmacol., Sect. Pharmacology, University<br />

of Messina; 4 Dept. Human Pathology, University of Pavia<br />

116. Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration<br />

related to temporal lobe epilepsy<br />

Biagioni Francesca 1 , Busceti C.L. 1 , Aronica E. 2* , Storto M. 1 , Battaglia G. 1 , Giorni F.S. 3 , Fornai<br />

F. 1,3 , Gra<strong>di</strong>ni R. 4 , Caricasole A. 5 , Nicoletti F. 1,6 , Bruno V. 1,6<br />

1 I.N.M. Neuromed, Pozzilli, Italy; 2 Dept. of Neuropathol., Univ. of Amsterdam, The<br />

Netherland; 3 Dept. of Hum. Morphol., Univ. of Pisa, Italy; 5 SienaBiotech, Siena, Italy; 5 Dept.<br />

of Exp. Med. and 6 Hum. Physiol. And Pharmacol. , Univ. “La Sapienza”, Rome, Italy<br />

117. Stimulation of proteinase-activated receptors 1 and 2 induces neurodegeneration in<br />

the rat olfactory system<br />

Dedoni Simona, Olianas M.C., Garau L., Onali P.<br />

Section of Biochemical Pharmacology, Department of Neuroscience, University of Cagliari,<br />

Cagliari, Italy.<br />

pag_sx.indd 1 30/05/2007 5.44.38


118. Histone deacetylase (HDAC) inhibitors reduce the in vitro and in vivo<br />

neuroinflammatory response in mice<br />

Faraco Giuseppe, Fossati S., Formentini L., *Mascagni P., *Fossati G., *Leoni F., Moroni F.,<br />

Chiarugi A.<br />

Dipartimento <strong>di</strong> Farmacologia Clinica e Preclinica, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Firenze<br />

*Italfarmaco S.p.a., Milan, Italy<br />

119. Neuroprotection by 17-estra<strong>di</strong>ol in whole rat urinary bladder subjected to<br />

ischaemia/reperfusion injury<br />

Valeri Aurora, Pessina F., Sgaragli G.<br />

Dip. Scienze Biome<strong>di</strong>che, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena, Via Aldo Moro 2 , 53100 Siena<br />

120. Heme oxygenase activity in immortalized hypothalamic neurons GT1-7<br />

Mores Na<strong>di</strong>a, Mancuso C., Errico S., Barone E., Preziosi P.<br />

Istituto <strong>di</strong> Farmacologia – Facoltà <strong>di</strong> Me<strong>di</strong>cina e Chirurgia<br />

Università Cattolica del Sacro Cuore - Roma<br />

121. Spinal cord injury and neural precursors. Homing, fate and recovery of function<br />

Bottai Daniele 1,2 , Maraschi L. 1 , Di Giulio A. M. 1 , Gorio A. 1,2 .<br />

1) Department of Me<strong>di</strong>cine, Surgery and Dentistry, University of Milan, Via A. <strong>di</strong> Ru<strong>di</strong>nì 8,<br />

20142 Milano, Italy; 2) Clinical Pharmacology IRCCS Humanitas Via Manzoni 56, 20089<br />

Rozzano, Milano, Italy.<br />

122. Melatonin protects from the long-term morphological and functional consequences<br />

of a neonatal hypoxic-ischemic brain injury in rats<br />

Carloni Silvia, Buonocore G. 1 , Perrone S. 1 , Longini M. 1 , Proietti F. 1 , Balduini W.<br />

Istituto <strong>di</strong> Farmacologia e Farmacognosia, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urbino “Carlo Bo”, Via S.<br />

Chiara 27, Urbino; 1 Dipartimento <strong>di</strong> Pe<strong>di</strong>atria, Ostetricia e Me<strong>di</strong>cina della Riproduzione,<br />

Sezione <strong>di</strong> Neonatologia Università <strong>di</strong> Siena, Policlinico Le Scotte Via M. Bracci, Siena<br />

127<br />

123. Pentoxifylline ameliorates calcium homeostasis and improves regeneration in<br />

skeletal muscle of dystrophic mdx mice: a comparison with the effects of a<br />

combined treatment prednisolone-taurine<br />

Bur<strong>di</strong> Rosa 1 , Rolland J.-F. 1 , Cozzoli A. 1 , Giannuzzi V. 1 , Liantonio A. 1 , Camerino G. M. 1 ,<br />

Andretta F. 2 , Confalonieri P. 2 , Mangieri D. 3 , Nico B. 3 , De Luca A. 1<br />

1 Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of<br />

Bari, Italy; 2 Muscular Pathology Unit, National Neurological Institute Carlo Besta, Milan, Italy,<br />

3 Department of Human Anatomy and Histology, University of Bari, Italy<br />

124. Effect of a chronic treatment with gentamicin on in vivo and ex vivo markers of<br />

dystrophic progression in mdx mouse<br />

Cozzoli Anna 1 , Bur<strong>di</strong> R. 1 , Cippone V. 1 , Nicchia G. P. 2 , Frigeri A. 2 , Camerino G.M. 2 , Mangieri<br />

D. 3 , Nico B. 3 , De Luca A. 1<br />

1 Dept. of Pharmacobiology, Faculty Pharmacy and 2 Dept. of General and Environmental<br />

Physiology, 3 Department of Human Anatomy and Histology, University of Bari, Italy<br />

125. VEGF overexpression via adeno-associated virus gene transfer promotes skeletal<br />

muscle regeneration and enhances muscle function in mdx mice<br />

Di Stefano Vincenzo 1 , Bitto A. 1 , Minutoli L. 1 , Altavilla D. 1 , Messina S. 2 , Vita G. 2 , Giacca M. 3 ,<br />

Caputi A.P. 1 , Squadrito F. 1<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina,<br />

2 Dept of Neurosci, Psych and Anaesthesiol, University of Messina, 3 Mol Med Lab, International<br />

Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy<br />

pag_dx.indd 1 30/05/2007 5.45.36


126. Possible antioxidant effect of sulphur mud- bath therapy in treatment of<br />

osteoarthrosis<br />

1,2 Costantino Maria, 2 Lampa E., 3 Giuberti G., 3 Caraglia M., 3 Abbruzzese A., 2 Filippelli A.<br />

1 CE.RI.S.T. (Center of Thermal Researches and <strong>Stu<strong>di</strong></strong>es srl), Naples, Italy; 2 Department of<br />

Experimental Me<strong>di</strong>cine–Pharmacological Division, II University of Naples-Italy; 3 Department of<br />

Biochemistry and Biophysics “F. Cedrangolo” – II University of Naples, Naples, Italy<br />

127. Bilirubin modulates neurotrophin redox signaling<br />

Mancuso Cesare 1 , Eboli M.L. 2 , Calabrese V. 3 , Preziosi P. 1 , Galeotti T. 2 , Pani G. 2<br />

From the Institutes of 1 Pharmacology and 2 General Pathology, Catholic University School of<br />

Me<strong>di</strong>cine, Largo F. Vito, 1 - 00168 Roma, Italy; 3 Dept. of Chemistry, Biochemistry and Mol.<br />

Biology Section, Faculty of Me<strong>di</strong>cine, University of Catania, 95100, Catania, Italy<br />

128. A study on biological activities of cyani<strong>di</strong>n-3-O-glucoside related to its antioxidant<br />

properties<br />

1 Speciale A., 1 Cimino F., 1 Chirafisi J., 1 Cristani M., 2 Ermito S., 1 Spinzia C., 1 Saija A.<br />

1 Dept. Farmaco-Biologico, School of Pharmacy, University of Messina - Vill. SS. Annunziata<br />

98168 Messina, Italy. 2 Institute of Gynecology and Obstetrics, University of Messina, Italy<br />

128<br />

129. Protective effect of Mn(III) tetrakis (4-benzoic acid) porphyrin on the inactivation<br />

of primary antioxidant enzymes in keratinocytes by photodynamically generated<br />

free ra<strong>di</strong>cals<br />

Muscoli Carolina 1 , Nistico’ S. 2 , Arcone R. 1 , Colica C. 1 , Visalli V. 1 , Vetrice D. 1 , Casale F. 1 , Del<br />

Vecchio I. 3 , Strangoli M.C. 3 , Mollace V. 1 , Rotiroti D. 3<br />

1 Dept of Pharmacobiol. Sciences, University of Catanzaro Magna Graecia, Italy; 2 School of<br />

Me<strong>di</strong>cine, Univesity of Rome “Tor Vergata”; 3 ISN-CNR<br />

130. Anticataractogenic property of -glutamylcysteine ethyl ester in an animal model of<br />

cataract<br />

Pannini Simone, Barberi L., Leone R. L, Casini P.<br />

Department of Farmacology “G. Segre”, University of Siena<br />

131. Assessment of blood and salivary antioxidant system in subjects with periodontitis<br />

and peri-implantitis<br />

Fiaschi Anna Ida, *Ruggero G., De Vuono G., Cerretani D., *Cozzolino A.<br />

Department of Pharmacology “G. Segre”, * Department of Odontostomatologic Science,<br />

Maxillo-Facial Surgery Division, University of Siena<br />

132. Status of lipid peroxidation in patients with osteoarthritis underwent a tammef<br />

system<br />

Fiaschi Anna Ida, *Battisti E., *Albanese A., Cerretani D., Runci F.<br />

Department of Pharmacology “G. Segre”, * Centre TAMMEF, University of Siena<br />

Farmacologia del dolore<br />

Poster 133 – 144<br />

133. Repeated treatment with AM404 reduces mechanical allodynia and thermal<br />

hyperalgesia in a model of neuropathic pain without central effects<br />

Sasso Oscar, La Rana G., Russo R., D’Agostino G., Iacono A., Meli R., Calignano A.<br />

Dep Experimental Pharmacology, Faculty of Pharmacy, via D. Montesano 49-Naples<br />

pag_sx.indd 1 30/05/2007 5.46.40


134. Antihyperalgesic and antiallodynic effect of purinergic antagonists in a mouse<br />

model of mononeuropathy: neuroinflammatory involved mechanisms<br />

Trovato Anna Elisa 1 , Franchi S. 1 , Magnaghi V. 2 , Panerai A. E. 1 , Procacci P. 4 , Rodella L. F. 3 ,<br />

Sacerdote P. 1 , Valsecchi A. E. 1 , Colleoni M. 1<br />

1 Dep. Pharmacol. Chem. Med. Toxicol, Univ. of Milan, 2 Dep. Endocrinol, Center Excell.<br />

Neurodegen. Dis., Univ. of Milan, 3 Divis. Anat., Dep. Biome<strong>di</strong>c. Sci. Biotechnol., Univ. of<br />

Brescia, 4 Inst. Histol. Embriol. Neurocytol., Univ. of Milan<br />

135. Phytoestrogen genistein reduces nociceptive hypersensitivity in the mouse chronic<br />

constriction injury model<br />

Valsecchi Anna E., Franchi S., Panerai A. E., Sacerdote P., Trovato A. E. , Colleoni M.<br />

Departement of Pharmacology, Chemoterapy and Me<strong>di</strong>cal Toxicology, University of Milan<br />

136. Blockade of the TRPV1 receptor and of the fatty acid amide hydrolase enzyme in a<br />

mouse model of neuropathic pain prevents pain-like behaviour and caspases<br />

activation<br />

Giordano Catia, Siniscalco D., Migliozzi A., Rossi F., Di Marzo V.°, Maione S.<br />

Istituto <strong>di</strong> Chimica Biomolecolare, CNR, Pozzuoli (NA), Italy; Department of Experimental<br />

Me<strong>di</strong>cine, section of Pharmacology, Second University of Naples, Via S. Maria <strong>di</strong> Costantinopoli<br />

16 – 80138 Naples, Italy<br />

137. The fatty-acid amide hydrolase inhibitor URB597 reduces neuropathic pain after oral<br />

administration in mice<br />

Russo Roberto, La Rana G., D’Agostino G., Sasso O., LoVerme J., Piomelli D., Malignano A.<br />

Department of Experimental Pharmacology, University of Naples, Italy.; Department of<br />

Pharmacology and the Center for Drug Discovery, University of California, Irvine<br />

138. N-arachidonoyl-serotonin: a fatty acid amide hydrolase inhibitor with antagonistic<br />

activity at TRPV1 receptors and analgesic properties in vivo<br />

Palazzo Enza 1 , De Petrocellis L. 2 , Petrosino S. 2 , Gatta L. 1 , Guida F. 1 , Ortar G. 3 , Rossi F. 1 ,<br />

Maione S. 1 , Di Marzo V. 2<br />

1 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, Second<br />

University of Naples, via Costantinopoli 16, 80138 Naples. 2 Endocannabinoid Research Group,<br />

Institutes of Cybernetics and of Biomolecular Chemistry, CNR, Pozzuoli (Naples). 3 Dipartimento<br />

<strong>di</strong> <strong>Stu<strong>di</strong></strong> Farmaceutici, Università <strong>di</strong> Roma 'La Sapienza”, Roma<br />

129<br />

139. A novel pharmacological approach for the treatment of neuropathic pain: toll-like<br />

receptor 4 antagonists as modulators of activated microglia<br />

Costa Barbara, Comelli F., Peri F., Granucci F., Bettoni I., Rossini C., Giagnoni G.<br />

Department of Biotechnology and Bioscience, University of Milano-Bicocca<br />

140. Ethanol causes neurogenic vaso<strong>di</strong>latation by TRPV1 activation and CGRP release in<br />

the trigeminovascular system of the guinea pig<br />

Benemei S. 1 , Nicoletti P. 1 , Trevisani M. 2 , Manconi M. 3 , De Siena G. 1 , Zagli G. 1 , Capone J.A. 2 ,<br />

Geppetti P. 1 , Pini L.A. 4<br />

1 Clinical Pharmacology Unit, Department of Critical care Me<strong>di</strong>cine and Surgery, University of<br />

Florence, 2 Center of Excellence for the Study of Inflammation and Headache Center,<br />

University of Ferrara, Ferrara, 4 Department of Laboratory Me<strong>di</strong>cine and Forensic Me<strong>di</strong>cine,<br />

University of Modena and Reggio Emilia, Italy<br />

141. Insertion/deletion polymorphism of the Angiotensin I-Converting Enzyme gene in<br />

migraine patients<br />

Bisogno Angelina (3) , Pizza V. (1) , Volpe G. (1) , Infante F. (2) , Schiavo G. (2) , Lamaida E. (1) ,<br />

Agresta A. (1) , Bianchi A. (3) , Capasso A. (3)<br />

1) Neurophysiopatology 2) Molecular Biology, S. Luca Hospital, Vallo della Lucania (SA),<br />

3) University of Salerno, Italy<br />

pag_dx.indd 1 30/05/2007 5.47.33


142. Genetic polymorphisms and migraine<br />

Longobar<strong>di</strong> Francesca (3) , Pizza V. (1) , Volpe G. (1), Infante F. (2) , Lamaida E. (1) , Agresta A. (1) ,<br />

Bisogno A. (3) , Bianchi A. (3) , Capasso A. (3)<br />

(1) Neurophysiopatology Service; (2) Molecular Biology Service, S. Luca Hospital, Vallo della<br />

Lucania (SA), ASL SA/3; (3) Department of Pharmaceutical Sciences, University of Salerno,<br />

Italy.<br />

143. Long-term intrathecal morphine in patients with chronic non-cancer pain upregulates<br />

mu opiod receptor gene expression in lymphocytes<br />

Campana Gabriele 1 , Raffaeli W. 2 , Sarti D. 2 , Spampinato S. 1<br />

1 Dept. Of Pharmacology - University of Bologna-Irnerio 48 - 40126 – Bologna; 2 Pain and<br />

Palliative Care Unit, Infermi Hospital, Rimini -Via Ovi<strong>di</strong>o - 47900 - Rimini<br />

144. Comparative production of the active tramadol metabolite o-desmethyl-tramadol<br />

(m1) in domestic animal species<br />

Zonca Annalisa*, Cagnar<strong>di</strong> P.*, Villa R.*, Ravasio G. # , Vettorato E. $ , Isola M. $ , Montesissa C. §<br />

*Dipartimento <strong>di</strong> Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Milano;<br />

§ Dipartimento <strong>di</strong> Sanità Pubblica Patologia Comparata ed Igiene Veterinaria, Padova;<br />

# Dipartimento <strong>di</strong> Scienze Cliniche Veterinarie, Milano; $ Dipartimento <strong>di</strong> Scienze Cliniche<br />

Veterinarie, Padova<br />

Sostanze <strong>di</strong> abuso<br />

Poster 145 – 161<br />

130<br />

145. Effect of uncontingent and subchronic administration of ad<strong>di</strong>ctive drugs on neuronal<br />

plasticity in the rat nucleus accumbens<br />

Ibba Federico 1 , Vinci S. 1 , Spiga S. 2 , Acquas E. 1, 3 , Di Chiara G. 1, 3<br />

1 Department of Toxicology and 3 Centre of Excellence on Neurobiology of Ad<strong>di</strong>ction, University<br />

of Cagliari; 2 Department of Animal Biology and Ecology, University of Cagliari<br />

146. Trend of drugs of abuse detection in the urine of patients of the university hospital<br />

of modena, during the period 1997-2006<br />

Coccia Ciro, Ferrari A., Castellana C. N., Poppi B., Pisa S., Bertolini A., Sternieri E.<br />

Toxicology and Clinical Pharmacology Section. Department of Laboratory Services University<br />

of Modena and Reggio Emilia, Italy<br />

147. Difference in the degree of nicotine dependence and development of depression<br />

between cannabis users and polidrug users<br />

Russo Giuseppina A. 1 , Garuana A. 2 , Mannucci C. 1 , Tedesco M. 1 ,<br />

Calapai G. 1<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Section of<br />

Pharmacology, School of Me<strong>di</strong>cine, University of Messina, Italy; 2 Territorial Service for<br />

Ad<strong>di</strong>ction (Ser.T.) of the District of Ribera – Local Sanitary Unit USL n°1, Agrigento (Italy)<br />

148. The cannabinoid antagonist SR 141716A reduces the increase of extra-cellular<br />

dopamine release in the rat nucleus accumbens induced by a novel high palatable<br />

food<br />

Melis Tiziana, Sanna F., Succu S., Argiolas A., Melis M.R.<br />

Beranrd B. Bro<strong>di</strong>e Department of Neurosciences, University of Cagliari, Italy<br />

149. Cannabinoid self-administration in the rat: gender <strong>di</strong>fferences and effect of<br />

ovariectomy<br />

Spano M. Sabrina 1,3 , Fattore L. 2,3 , Altea S. 1 , Angius F. 1 , Fadda P. 1,3 1, 2,3<br />

, Fratta W. 1 Department of Neuroscience, University of Cagliari ; 2 Institute of Neuroscience CNR, Section<br />

of Cagliari; 3 Centre of Excellence "Neurobiology of Dependence", University of Cagliari<br />

pag_sx.indd 1 30/05/2007 5.48.33


150. Psychosis onset: use of cannabis x COMT genotype interaction. A case-only design<br />

analysis in a first-episode psychosis sample<br />

La Cascia Caterina 1,2 , Di Forti M. 2 , Murray R.M. 2 , La Barbera D. 1 , Butt A. 2 , Mondelli V. 2 ,<br />

Eyeson J. 2 , Navari S. 2 , Aas M. 2 , Clifford D. 2 , Dazzan P. 2 , Pariante C. 2 , Morgan C. 2 , Freeman<br />

B. 2 , Luzi S. 2 , Dempster D. 2 , Rivera M. 2 , Collier D. 2 , Powell J. 2 , Cannizzaro G. 3<br />

1 Dept. of Clinical Neurosciences, University of Palermo, 2 Institute of Psychiatry, King’s College<br />

London, UK, 3 Dept. of Pharmacological Sciences, University of Palermo<br />

151. Flumazenil selectively prevents the increase in 4 subunit gene expression and an<br />

associated change in GABA A receptor function induced by ethanol withdrawal<br />

Caria Stefania 1 , Biggio F. 1 , Gorini G. 1 , Murru L. 1 , Sanna E. 1,2 , Follesa P. 1,2 ,Biggio G. 1,2<br />

University of Cagliari, Department of Experimental Biology, Section of Neuroscience 1 ; Center<br />

of Excellence for the Neurobiology of Dependence 2 , 09123 Cagliari, Italy<br />

152. Pregnenolone sulfate enhancement of GABA release in the developing rat<br />

cerebellum is me<strong>di</strong>ated by presynaptic nmdars and is modulated by ethanol<br />

Carta Mario, Murru L., Vir<strong>di</strong>s F., Brockmann M.D., Marras R., Sanna E., Biggio G.<br />

Dept. Experimental Biology, Sect of Neuroscience, and Center of Excellence for the<br />

Neurobiology of Dependence. Cittadella Universitaria, SS 554 Km 4,500, 09042, Monserrato,<br />

Cagliari, Italy<br />

153. Neurosteroid-me<strong>di</strong>ated increase of GABAergic tonic inhibition in rat dentate gyrus<br />

granule cells by ethanol<br />

Sanna Enrico,Talani G., Zucca S., Biggio G.<br />

Dept. Experimental Biology, Sect. of Neuroscience, and Center of Excellence for the<br />

Neurobiology of Drug Dependence, University of Cagliari, Cittadella Universitaria, Monserrato,<br />

Cagliari, Italy<br />

131<br />

154. Activation of transient receptor potential vanilloid type 1 (TRPV1) by ethanol: role<br />

of endogenous lipid me<strong>di</strong>ators<br />

Campi B., Gatti R., Andre E., Geppetti P., Trevisani M.<br />

Inter<strong>di</strong>sciplinary Centre of Excellence for the Study of Inflammation (ICSI), University of<br />

Ferrara, Ferrara, Italy<br />

155. Transient receptor potential vanilloid 1, substance P & reactive oxygen species<br />

me<strong>di</strong>ate ethanol-induced gastric injury<br />

Trevisani M. 1 , Gazzieri D. 1 , Harrison S. 2 , Cottrell G.S. 5 , Andre E. 1 , Massi D. 3 , Zecchi S. 4 ,<br />

Lungarella G. 6 , Bunnett N.W. 5 , Geppetti P. 1,2<br />

1 Center of Excellence for the Study of Inflammation, University of Ferrara; Departments of<br />

2 Critical Care Me<strong>di</strong>cine and Surgery, 3 Human Pathology and Oncology, and 4 Anatomy,<br />

University of Florence; 5 Departments of Surgery and Physiology, University of San Francisco,<br />

6 Department of Physiopathology, University of Siena<br />

156. Ethanol induced dopamine release in the rat mesolimbic system. Role of<br />

acethaldehyde<br />

Sirca Donatella 1 , Mereu M. 1 , Golosio A. 1 , Enrico Paolo 2 , Diana M. 1<br />

1) “G. Minar<strong>di</strong>” Laboratory of Cognitive Neuroscience, Department of Drug Sciences;<br />

2) Department of Biome<strong>di</strong>cal Sciences. University of Sassari, 07100 Sassari, Italy<br />

157. RITIRATO<br />

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158. Intermittent intoxication with ethanol vapor induces a long-lasting hypnotic<br />

tolerance and behavioral sensitivity in rat<br />

Rimon<strong>di</strong>ni R. † , Sommer W.*, Heilig M.*, Dall’Olio R. † , Locchi F. † , Gandolfi O †<br />

*Laboratory of Clinical and Translational <strong>Stu<strong>di</strong></strong>es, National Institute on Alcohol Abuse and<br />

Alcoholism, National Institutes of Health, Bethesda, MD 20892;<br />

† Department of<br />

Pharmacology, University of Bologna, 40128 Bologna, Italy<br />

159. Reduction of ethanol drinking following chronic administration of the antiepileptic<br />

levetiracetam in genetically selected alcohol preferring rats<br />

Stopponi Serena, Postolache Cristita, Nazzareno C., Economidou D., Fedeli A., Massi M.,<br />

Ciccocioppo R.<br />

University of Camerino, Italy<br />

160. Effect of the selective fatty acid amide hydrolase inhibitor URB597 on ethanol abuse<br />

related behaviours in the rat<br />

Braconi Simone, Piomelli D.*, Duranti A. § , Tonini A. § , Tarzia G. § , Cannella N., Massi M.,<br />

Ciccocioppo R., Cippitelli A.<br />

Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy;<br />

*Gillespie Neuroscience Facility, University of California, Irvine, USA; § Institute of Me<strong>di</strong>cinal<br />

Chemistry, University of Urbino “ Carlo Bò”, Italy<br />

132<br />

161. Neuropeptide S: a new neurotrasmitter system involved in relapse to alcoholseeking<br />

behaviour<br />

1 Cannella Nazzareno, 1 Economidou D., 1 Kallupi M., 2 Guerrini R., 3 Calò G., 1 Ciccocioppo R.<br />

1 Dept. of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy; 2 Dept of<br />

Pharmaceutical Science and, 2 Dept. of Pharmacology, University of Ferrara, Italy<br />

Farmacologia della funzione respiratoria<br />

Poster 162 – 172<br />

162. Role of TGF- on MAP kinase phosphorylation and cell proliferation in primary<br />

cultures of human lung fibroblast<br />

Sullo Nikol, Gallelli L., De Nardo M., Orlotti D., Russo M., Marrocco G., D’Agostino B., De Sarro<br />

GB., Rossi F.<br />

Department of Experimental Me<strong>di</strong>cine, Sect. of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />

Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy.<br />

163. Ethanol sensitises TRPV1-me<strong>di</strong>ated cough in guinea pigs by a protein kinase C-<br />

dependent pathway<br />

Gatti Raffaele 1 , Andre E. 1 , Campi B. 1 , Geppetti P. 1, 2 Trevisani M. 1<br />

1 Inter<strong>di</strong>sciplinary Centre of Excellence for the Study of Inflammation (ICSI), University of<br />

Ferrara, Ferrara, Italy; 2 Department of Critical Care Me<strong>di</strong>cine and Surgery, University of<br />

Florence, Florence, Italy<br />

164. The role of ceramide pathway in asthma<br />

Giannini Lucia a , Bani D. b , Uliva C. a , Marzocca C. a , Comhair Suzy A.A. c , Erzurum Serpil C. c , Li<br />

D. d , Ndengele Michael d , Salvemini D. d , Masini E. a<br />

a Department of Preclinical and Clinical Pharmacology, and b Anatomy, Histology and Forensic<br />

Science, Section of Histology, University of Florence, Italy; c Pulmonary, Critical Care Me<strong>di</strong>cine<br />

and Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation,<br />

Cleveland, USA; d Internal Me<strong>di</strong>cine, Division of Pulmonary, Critical Care and Sleep Me<strong>di</strong>cine,<br />

St Louis University, St Louis, USA<br />

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165. Role of nociceptin and its receptor in animal model of asthma<br />

Orlotti Donatella, De Nardo M., Russo M., Sullo N., Marrocco G., Rossi F., D’Agostino B.<br />

Department of Experimental Me<strong>di</strong>cine, Sect. of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />

Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy<br />

166. Activation of protease-activated receptor-2 reduces airways inflammation in<br />

experimental allergic asthma<br />

Russo Mariangela, Orlotti D., De Nardo M., Marrocco G., Sullo N., Guastafierro MG., Rossi F.,<br />

D’Agostino B.<br />

Department of Experimental Me<strong>di</strong>cine, Sect. of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />

Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy<br />

167. M 3 muscarinic receptors in peripheral lung parenchima of patients with chronic<br />

obstructive pulmonary <strong>di</strong>sease<br />

Vincenzi F. 1 , Varani K. 1 , Caramori G. 2 , Tosi A. 1 , Gessi S. 1 , Merighi S. 1 , Fogli E. 1 , Sacchetto V.<br />

1 , Simioni C. 1 , Papi A. 2 , Borea P.A. 1<br />

Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Section 1 and Respiratory<br />

Disease Section 2 , University of Ferrara, Italy<br />

168. Glycogen synthase kinase-3 inhibition attenuates the development of bleomycininduced<br />

lung injury<br />

1,2 Cuzzocrea S., 1,2 Genovese T., 1,2 Mazzon E., 3 Esposito E., 1 Muià C., 4 Abdelrahman M., 1,2 Di<br />

Paola R., 2 Bramanti P., 4 Thiemermann C.<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />

University of Messina, Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy;<br />

3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”, Italy; 4 The<br />

William Harvey Research Institute, Centre for Experimental Me<strong>di</strong>cine, Nephrology and Critical<br />

Care, St Bartholomew’s and The Royal London School of Me<strong>di</strong>cine and Dentistry, London, UK<br />

133<br />

169. Modulation of the non-adrenergic, non-cholinergic inhibitory system by adenosine<br />

A 1 and A 3 receptors in the guinea-pig isolated trachea<br />

Dellabianca Antonio*, De Amici E.*, Tonini S.*, De Angelis S.**, Faniglione M.**, Candura S.<br />

M*, Tonini M.**<br />

*Dept. Preventive Occupational and Community Me<strong>di</strong>cine, University of Pavia; **Dept. of<br />

Physiological and Pharmacological Sciences, University of Pavia<br />

170. New roles for cysteinyl leukotriene in asthma: from airway remodelling to 2 -<br />

Adrenoreceptor dysfunction<br />

Rovati G. Enrico 1 , 2 Baroffio M. 1 Citro S., 1 Capra V., 2 Crimi C., 2 Brusisco V.<br />

1 Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Dept. of<br />

Pharmacological Sciences, University of Milan; and 2 Respiratory Pathophysiology Unit, Dept.<br />

of Internal Me<strong>di</strong>cine, University of Genoa<br />

171. Sphingosine-1-phosphate/Sphingosine kinase pathway is involved in mouse airway<br />

hyper-responsiveness<br />

Roviezzo Fiorentina, Di Lorenzo A., Bucci M., Brancaleone V., De Gruttola L., Vellecco V.,<br />

Rossi F., D’Agostino B., Cirino G.<br />

Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples-<br />

Federico II-; Department of Experimental Me<strong>di</strong>cine-Section of Pharmacology, Faculty of<br />

Me<strong>di</strong>cine and Surgery, 2nd University of Naples<br />

pag_dx.indd 1 30/05/2007 5.50.41


172. Evidence for a role of adenosine A1 receptor in bronchial hyperreactivity of<br />

sensitized wistar rats<br />

Alfieri Alessio, Cicala C.<br />

Department of Experimental Pharmacology, University of Naples “Federico II”, Naples<br />

Farmacologia dell'apparato <strong>di</strong>gerente<br />

Poster 173 – 184<br />

173. APP, a novel selective adenosine deaminase inhibitor, is effective against<br />

experimental colitis<br />

Antonioli Luca 1 , Fornai M. 1 , Colucci R. 1 , Ghisu N. 1 , Da Settimo F. 2 , Natale G. 3 , Vir<strong>di</strong>s A. 4 ,<br />

Breschi M.C. 5 , Del Tacca M. 1 , Blan<strong>di</strong>zzi C. 1<br />

1 Division of Pharmacology and Chemotherapy,<br />

1,4 Department of Internal Me<strong>di</strong>cine,<br />

2 Department of Pharmaceutical Sciences, 3 Department of Human Morphology and Applied<br />

Biology, and 5 Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology,<br />

University of Pisa, Pisa, Italy<br />

174. Effects of the non-peptidyl low molecular weight ra<strong>di</strong>cal scavenger IAC in DNBSinduced<br />

colitis in rats<br />

Vasina Valentina * , Broccoli M. * , Ursino M. G. * , Soleti A. # , Paolini M. * , De Ponti F. *<br />

* Department of Pharmacology, Alma Mater <strong>Stu<strong>di</strong></strong>orum - University of Bologna, Italy;<br />

# Medestea Research, <strong>Torino</strong>, Italy<br />

134<br />

175. The NK 1 receptor antagonist SSR140333 ameliorates experimental colitis in rats<br />

Ursino Maria Grazia, Vasina V., Croci Tiziano*, De Ponti F.<br />

Dept. of Pharmacology, University of Bologna, Bologna, Italy *Sanofi-Aventis Research<br />

Centre, Milan, Italy<br />

176. Responsiveness of longitu<strong>di</strong>nal and circular muscle to relaxing me<strong>di</strong>ators is<br />

<strong>di</strong>fferentially affected in rat hypertrophied ileum<br />

Bertoni Simona, Ghizzar<strong>di</strong> P., Tognolini M., Ballabeni V., Impicciatore M., Barocelli E.<br />

Dipartimento <strong>di</strong> Scienze Farmacologiche, Biologiche e Chimiche Applicate. Università <strong>degli</strong><br />

<strong>Stu<strong>di</strong></strong> <strong>di</strong> Parma. Viale Usberti 27/a, 43100 Parma, Italy<br />

177. In rat ileum adenosine deaminase is not only an ecto- but also an exo-enzyme<br />

Calligaro Giulia, Bin A., Giron M. C., Gaion R.M.<br />

Department of Pharmacology and Anesthesiology, University of Padova<br />

178. Herpes simplex virus-1 infection alters the carbachol- and KCl-induced contractions<br />

in rat small intestine<br />

Zoppellaro Chiara 1 , Brun P. 2 , Giron M. C. 1 , Bin A. 1 , Gaion R.M. 1 , Castagliuolo I. 2<br />

1 Department of Pharmacology and Anesthesiology, University of Padova; 2 Department of<br />

Histology, Microbiology & Me<strong>di</strong>cal Biotechnologies, University of Padova<br />

179. Adenosine receptors and metabolism in the intestinal tract<br />

Bin Anna 1 , Giron M.C. 1 , Calligaro G. 1 , Castagliuolo I. 2 , Gaion R.M. 1<br />

1 Department of Pharmacology and Anesthesiology, University of Padova<br />

2 Department of Histology, Microbiology and Me<strong>di</strong>cal Biotechnology, University of Padova<br />

180. Role of A 2A adenosine receptors in the regulation of human colon motility<br />

Fornai Matteo 1 , Antonioli L. 1 , Colucci R. 1 , Ghisu N. 1 , Buccianti P. 2 , Chiarugi M. 2 , Blan<strong>di</strong>zzi C. 1 ,<br />

Del Tacca M. 1<br />

1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, and<br />

2 Department of Surgery, University of Pisa, Pisa, Italy<br />

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181. Gender-related role of nitric oxide in electrically evoked contractions in human<br />

colonic circular muscle<br />

Maselli M.A., Trisolini P., Pezzolla F., Demma I., De Ponti F.°<br />

Scientific Institute of Gastroenterology “S. de Bellis”, Castellana Grotte, Bari; °Department of<br />

Pharmacology, University of Bologna, Bologna, Italy<br />

182. Role of 5-HT receptors in modulating propulsive activity and accommodation in the<br />

guinea pig <strong>di</strong>stal colon<br />

Balestra Barbara*, Cervio E.*, Sternini C.**, De Giorgio R. # , Tonini M.*<br />

*Dept. of Physiological & Pharmacological Sciences, University of Pavia, **Dept. of Me<strong>di</strong>cine<br />

and Neurobiology, David Geffen School of Me<strong>di</strong>cine, University of California, Los Angeles,<br />

# Dept. of Internal Me<strong>di</strong>cine & Gastroenterology, University of Bologna, Italy<br />

183. The effects of UFP112, a novel nociceptin/orphanin FQ-NOP receptor ligand, on<br />

colonic propulsion and defecation in physiological and pathological con<strong>di</strong>tions<br />

Broccardo M. a , Agostini S. a , Guerrini R. b , Improta G. a , Linari G. a , Petrella C. a<br />

a Dept. Human Physiology and Pharmacology, University of Rome “Sapienza”, b Dept.<br />

Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, Italy<br />

184. Effect of modeled microgravity con<strong>di</strong>tions on rat intestinal transit<br />

Peana Alessandra T. 1 ., Marzocco S. 2 , Pulighe E. 1 , Bianco G. 2 , Proto Pippia 1 , Pinto A. 2 ,<br />

Autore G. 2<br />

1 Department of Drug Science, University of Sassari, via Muroni 23/a, 07100, Sassari;<br />

2 Department of Pharmaceutical Science, University of Salerno, via Ponte don Melillo, 84084,<br />

Fisciano, Salerno<br />

Farmacologia del metabolismo e del sistema endocrino<br />

Poster 185 – 193<br />

135<br />

185. Menopausal transition: a possible risk factor for neurodegenerative events<br />

Rigamonti Antonello E. 1 , Bonomo S. M. 1 , Giunta M. 1 , Galimberti D. 2 , Guaita A. 3 , Gagliano M.<br />

G. 4 , Müller E. E. 1 , Cella S.G. 1<br />

1 Department of Me<strong>di</strong>cal Pharmacology and 2 Department of Neurological Sciences, Fondazione<br />

IRCCS Ospedale Maggiore Policlinico, Milan, Italy; 3 Geriatric Institute “Camillo Golgi”,<br />

Abbiategrasso, Italy; 4 Department of Transfusion Me<strong>di</strong>cine, “San Carlo Borromeo” Hospital,<br />

Milan, and CEND, University of Milan<br />

186. Effects of the phytoestrogen genistein on some pre<strong>di</strong>ctors of car<strong>di</strong>ovascular risk in<br />

osteopenic, postmenopausal women: a randomized, double-blind, placebocontrolled<br />

study<br />

Marini Herbert 1 , Minutoli L. 2 , Polito F. 2 , Bitto A. 2 , Altavilla D. 2 , Frisina N. 3 , D’Anna R. 4 , Lubrano<br />

C. 5 , Adamo E. B 1 , Caputi A. P. 2 ,Squadrito F. 2<br />

1 Dept. of Bioch., Phys. and Nutr. Sci., 2 Dept. of Clin. and Exp. Med. and Pharm., 3 Dept. of Int.<br />

Med., 4 Dept. of Obst. and Gyn. Sci., Messina; 5 Dept. of Med. Physiop., “La Sapienza” Univ.,<br />

Rome, Italy<br />

187. In vitro and in vivo anti-inflammatory activities of pseudomorelin, a ghrelin-mimetic<br />

pseudotetrapeptide<br />

Ghè Corrado, Baragli A., Arnoletti E., Deghenghi R., Muccioli G.<br />

Division of Pharmacology, Department of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine,<br />

University of Turin, Turin, Italy<br />

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188. Ghrelin and des-acyl ghrelin induce murine C2C12 myoblasts <strong>di</strong>fferentiation and<br />

fusion into myotubes<br />

Arnoletti Elisa § , Filigheddu N.*, Ghè C. § , Ponzetto C. ‡ , Crepal<strong>di</strong> T. ‡ , Graziani A.*, Muccioli G. §<br />

§ Division of Pharmacology and ‡ Anatomy, Department of Anatomy, Pharmacology and<br />

Forensic Me<strong>di</strong>cine, University of Turin, Turin, Italy; *Department of Me<strong>di</strong>cal Sciences,<br />

University of Piemonte Orientale “Amedeo Avogadro”, Novara, Italy<br />

189. Endocrine and extraendocrine effects of ghrelin and novel synthetic analogs<br />

Bulgarelli Ilaria a , Bresciani E. a , Tamiazzo L. a , Rapetti D. a , Perrissoud D. b , Torsello A. a,c ,<br />

Locatelli V. a,c<br />

a Department of Experimental Me<strong>di</strong>cine, University of Milan Bicocca, Monza, Italy; b Zentaris<br />

GmbH, Frankfurt, Germany; c Interdepartmental Center for Bioinformatics and Proteomics,<br />

University of Milano-Bicocca, Monza, Italy<br />

190. Efects of irbesartan on the myocar<strong>di</strong>al ischemia/reperfusion injury in ZDF rats with<br />

metabolic syndrome<br />

Di Filippo Clara 1,2 , Lampa E. 1,2 , Martella R. 3 , Vargiu G. 4 , Paizis G. 4 , D’Amico M. 1,2<br />

1 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology L. Donatelli, 2 ”Excellence<br />

Centre for Car<strong>di</strong>ovascular Disease”, and 3 Department of Geriatrics and Metabolic Diseases,<br />

2nd University of Naples, Italy. 4 Sanofi-Aventis, Milano<br />

136<br />

191. Effects of liposome-encapsulated pyrazolo-pyrimi<strong>di</strong>ne derivate on the growth of<br />

human thyroid cancer cells<br />

1 Celano Marilena, 1 Cosco D., 2 Navarra M., 1 Alcaro S., 3 Schenone S., 1 Procopio S., 1 Varano E.,<br />

4 Botta M., 1 Fresta M., 1 Russo D.<br />

1 Dip. <strong>di</strong> Scienze Farmacobiologiche Univ. Catanzaro, 2 Dip. Farmacobiologico, Univ. Messina,<br />

3 Dip. Scienze Farmaceutiche, Univ. Genova, e 4 Dip. Farmaco Chim. Tecnol., Univ. Siena<br />

192. Effect of testosterone on p70S6k phosphorylation in skeletal muscle cell coltures<br />

1 Dattolo Maria G., 1 Saviano R., 1 La Rana G., 1 Calignano A., 2 Miniaci M. , 1 Scotto P.<br />

1 Dept.of Experimental Pharmacology, University of Napoli “Federico II”; 2 Dept.of Experimental<br />

and Clinical Me<strong>di</strong>cine, University of Catanzaro, Italy<br />

193. Endogenous benzo<strong>di</strong>azepines and intestinal bacterial flora in normal and<br />

pathological con<strong>di</strong>tions<br />

Campioli Enrico § , Avallone R. § , Ferrieri A. § , Baral<strong>di</strong> M. §°<br />

§ Department of Biome<strong>di</strong>cal Sciences, Via Campi 287, 41100 Modena, Italy, °National<br />

InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN),<br />

Farmacologia dell'infiammazione<br />

Poster 194 – 204<br />

194. Effects of a methanolic extract of sedum telephium in LPS-activated rat<br />

macrophages<br />

Polito Francesca 1 , Bitto A. 1 , Minutoli L. 1 , Fiumara T. 1 , Giachetti D. 2 , Miral<strong>di</strong> E. 2 , Biagi M. 2<br />

Squadrito F. 1 , Caputi A. P. 1 , Altavilla D. 1<br />

1 Dept of Exp and Clinical Me<strong>di</strong>cine and Pharmacology and 2 Dept of Environmental Sci, Section<br />

of Pharm Biol, University of Siena, Italy<br />

195. Different phenotypes of microglia activation<br />

Dello Russo Cinzia, Tringali G., Navarra P.<br />

Istituto <strong>di</strong> Farmacologia, Università Cattolica del S Cuore, Largo F Vito 1 - Roma<br />

pag_sx.indd 1 30/05/2007 5.53.35


196. Mapping of the human promoter of GNB2L1 gene enco<strong>di</strong>ng the RACK1 protein and<br />

its regulatory role in the immunosenescence<br />

Del Vecchio Igor 1 , Zuccotti A. 1 , Corsini E. 2 , Racchi M. 1 , Lucchelli A. 1 , Govoni S. 1<br />

1 Department of Experimental and Applied Pharmacology, University of Pavia, Viale Taramelli<br />

14, 27100 Pavia, Italy; 2 Department of Pharmacological Sciences, University of Milano, Via<br />

Balzaretti 9, 20133 Milan, Italy<br />

197. Antinflammatory activity and gastroprotective effect of the antioxidant compound<br />

iacvita in rats<br />

Zavatti Manuela, Zanoli P., Montanari C., Vezzalini F. , Baral<strong>di</strong> M.<br />

Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology and National InterUniversity<br />

Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and<br />

Reggio Emilia, Modena, Italy<br />

198. The glucocorticoid-induced leucine zipper (GILZ) protects against DNBS-induced<br />

colitis development<br />

Velar<strong>di</strong> Enrico 1 , Donato V. 1 , Bruscoli S. 1 , Mazzon E. 2 , Cannarile L. 1 , Cuzzocrea S. 2 , Riccar<strong>di</strong><br />

C. 1<br />

1 Dept. Clinical and Experimental Me<strong>di</strong>cine, Sect. Pharmacology, Perugia University Me<strong>di</strong>cal<br />

School, 06122, Perugia, and 2 Dept Clinical and Experimental Me<strong>di</strong>cine and Pharmacology,<br />

Messina University Me<strong>di</strong>cine School, Torre Biologica, Policlinico Universitario, 98123, Italy<br />

199. Mucin depleted foci (MDF) are useful biomarkers to study inflammation-induced<br />

colon carcinogenesis in rodents<br />

Caderni Giovanna, Femia A.P., Dolara P., Tarquini E., Salvadori M.<br />

Department of Pharmacology University of Florence, Florence, Italy<br />

137<br />

200. Local administration of palmitoylethanolamide reduces chronic granulomaassociated<br />

angiogenesis in rat<br />

D’Amico Alessandra, De Filippis D., Iuvone T.<br />

1 Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples<br />

Federico II, Via D. Montesano 49, 80131 Naples, Italy<br />

201. Contribution of 4 1 integrin to the antiallergic effect of levocabastine in<br />

experimental conjunctivitis<br />

Spartà Antonino M., Qasem Ahmed R., Bucolo C., Baiula M., Govoni P., Fascì D., Spampinato<br />

S.<br />

Department of Pharmacology, University of Bologna<br />

202. Protection against UVB-induced damage in rabbit eye by 4-coumaric acid<br />

Lodovici Maura 1 , Morbidelli L. 2 , Akpan V. 1 , Ziche M. 2 , Dolara P. 1<br />

1 Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence<br />

(Italy); 2 Department of Molecular Biology, University of Siena, Via A. Moro 2, 53100 Siena<br />

(Italy)<br />

203. CT327, a novel therapeutic agent for topical treatment of psoriasis<br />

Barone Domenico, Bertarione Rava Rossa L., Traversa S., Mainero V., Oderda C., Pincelli C.*,<br />

Marconi A.*, Fumero S.<br />

Creabilis therapeutics SpA, Via Ribes, 5 – 10010 Colleretto Giacosa (TO), Italy; *University of<br />

Modena e Reggio Emilia, Via del Pozzo, 71 – 41100 Modena, Italy<br />

pag_dx.indd 1 30/05/2007 5.54.15


204. Role of peroxisome proliferators activated receptors alpha (PPAR-) in acute<br />

pancreatitis induced by cerulean<br />

1 De Sarro Angelina, 1,2 Mazzon E., 1,2 Genovese T., 1,2 Di Paola R., 1 Muià C., 1 Malleo G.,<br />

3‡ Esposito E., Caputi A.P. 1,2 ., Cuzzocrea S. 1,2<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />

University of Messina, Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy;<br />

3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”, Napoli, Italy<br />

Chemioterapia antibatterica, antivirale e antineoplastica<br />

Poster 21 – 30<br />

205. Analysis of the thymidylate synthase gene structure in colorectal cancer patients,<br />

and its possible relation with the 5-fluorouracil drug response<br />

Sanguedolce Rosario 1 , Gulotta G. 2 , Cajozzo M. 3 , Agrusa A. 2 , Feo S. 4 , Sanguedolce G. 1 ,<br />

Calascibetta A. 1<br />

1 Dipartimento <strong>di</strong> Scienze Farmacologiche, 2 Chirurgia Generale e d’Urgenza, 3 Dipartimento <strong>di</strong><br />

Discipline Chirurgiche ed Oncologiche, 4 DOSAC. University of <strong>Stu<strong>di</strong></strong>es of Palermo<br />

138<br />

206. Irinotecan metronomic chemotherapy in metastatic colorectal cancer patients: a<br />

pharmacokinetic and pharmacodynamic study<br />

Bocci Guido 1 , Allegrini G. 2 , Fioravanti A. 1 , Orlan<strong>di</strong> P. 1 , Loupakis Fotios 2 , Barletta M. T. 2 , Di<br />

Paolo A. 1 , Falcone A. 2 , Danesi R. 1 , Del Tacca M. 1<br />

1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />

Pisa, Pisa; 2 Division of Me<strong>di</strong>cal Oncology, General Hospital, Livorno<br />

207. Adenosine receptor A3: role and expression in human thyroid cancer<br />

Pinto A., Morello S., Petrella A., Festa M., Popolo A., Parente L., Chiappetta G.*<br />

Department of Pharmaceutical Sciences, University of Salerno, Italy; *Tumor Institute,<br />

Fondazione Senatore G. Pascale, Naples, Italy<br />

208. Antimetastatic effect of a novel non competitive CXCR1/CXCR2 inhibitor in human<br />

melanoma<br />

*Bruno Annalisa, *Mosca M., *Buanne P., °Del Bufalo D., °Desideri M., °Giorgini S., § Ruco L.,<br />

*Allegretti M., *Gloaguen I., *Bizzarri C., * Melillo G., *Bertini R., °Zupi G.<br />

*Dompé pha.r.ma s.p.a., via Campo <strong>di</strong> Pile, 67100 L’AQUILA, ITALY; °Regina Elena Cancer<br />

Institute, via delle Messi d’Oro 156, 00158 ROME, ITALY; § S.Andrea Hospital, University La<br />

Sapienza, via <strong>di</strong> Grottarossa 1035, 00189 ROME, ITALY<br />

209. Pharmacokinetics of cisplatin during intraperitoneal hyperthermic chemotherapy<br />

perfusion (IHCP) in patients with peritoneal carcinomatosis<br />

*Cerretani Daniela, *Ferraro M. T., *Fiaschi A. I., *Miceli G. B.,**Cioppa T., **Marrelli<br />

D.,**Corso G.,**Pedrazzani C.,**Roviello F.<br />

*Department of Pharmacology “G. Segre”, University of Siena; **Department of Human<br />

Patology and Oncology, Unit of Surgical Oncolgy, University of Siena<br />

210. Effects of zoledronic acid on cathepsin K circulating levels in patients with bone<br />

metastasis<br />

Leto Gaetano¹, Tumminello F.M¹., Badalamenti G.², Incorvaia L.², Fulfaro F.², Crescimanno<br />

M.¹, Flan<strong>di</strong>na C.¹, Gebbia N.²<br />

¹Lab. Chemioter. Sperimentale and ²U.O. <strong>di</strong> Oncologia Me<strong>di</strong>ca, Dipartimento <strong>di</strong> Discipline<br />

Chirurgiche ed Oncologiche; Policlinico Universitario P. Giaccone, 90127 Palermo, Italy<br />

pag_sx.indd 1 30/05/2007 5.55.11


211. Therapeutic drug monitoring of antiretroviral agents: determination of plasma<br />

concentrations by means of a high-pressure liquid chromatographic technique<br />

Pinetti Diego i , Motta A. ii , Gallesi D. i , Guaral<strong>di</strong> G. ii<br />

i Toxicology and Clinical Pharmacology, Department of Laboratory Services, University of<br />

Modena and Reggio Emilia; ii Department of Me<strong>di</strong>cine and Me<strong>di</strong>cine Specialities, University of<br />

Modena and Reggio Emilia<br />

212. H 2 S and no affect intracellular killing of can<strong>di</strong>da albicans modulating GSH levels<br />

Grosso Silvia 1 , Caronno A. 1 , Lucini V. 1 , Pannacci M. 1 , Sullo N. 2 , Scaglione F. 1<br />

1 Department of Pharmacology, University of Milan, Milan, Italy; 2 Depatment of Experimental<br />

Me<strong>di</strong>cine- Section of Pharmacology, II University of Naples, Naples, Italy<br />

213. Pharmacokinetic/pharmacodynamic of macrolides in an in vivo model of Chlamy<strong>di</strong>a<br />

pneumoniae's pneumonia<br />

Caronno Alessia, Lucini V., Grosso S., Pannacci M., Scaglione F.<br />

Department of Pharmacology, University of Milan, Milan, Italy<br />

214. Bioavailability improvement of polymyxin B by calcium alginate/chitosan<br />

microparticles<br />

Rossi Tiziana°, Baggio G.°, Coppi A.°, Bruni E.°, Ruberto A.°, Iannuccelli V.* Coppi G.*<br />

University of Modena and Reggio Emilia- Italy: °Department of Biome<strong>di</strong>cal Sciences- Section<br />

of Pharmacology; * Department of Pharmaceutical Sciences, 287 G. Campi st 41100 Modena<br />

Italy<br />

Immunofarmacologia<br />

Poster 215 – 224<br />

139<br />

215. Atorvastatin treatment influences polymorphonuclear leukocyte function: a<br />

longitu<strong>di</strong>nal study<br />

Loraschi Anna, Schembri L., Maio R.C., Marino F., Cosentino M., Guasti L., Rasini E., Legnaro<br />

M., Colombo C., Cereda E., Cimpanelli M., Castiglioni L., Tozzi M.*, Castelli P.*, Venco A.,<br />

Lecchini S.<br />

Department of Clinical Me<strong>di</strong>cine, Section of Experimental and Clinical Pharmacology and<br />

*Department of Surgical Surgical Science, University of Insubria, Varese, Italy<br />

216. Treatment with simvastatin mo<strong>di</strong>fies AT 1 R expression and function in<br />

polymorphonuclear leukocyte of high car<strong>di</strong>ovascular risk subjects: a longitu<strong>di</strong>nal<br />

study<br />

Maio Ramona Consuelo, Marino F., Guasti L., Cosentino M., Rasini E., Ferrari M., Cimpanelli<br />

M.G., Loraschi A., Legnaro M., Cereda E., Crespi C., Venco A., Lecchini S.<br />

Department of Clinical Me<strong>di</strong>cine, Section of Experimental and Clinical Pharmacology,<br />

University of Insubria, Varese<br />

217. Effects of atorvastatin treatment on the modulation of leukocyte function in patients<br />

undergoing peripheral vascular intervention: a longitu<strong>di</strong>nal study<br />

Schembri Laura, Loraschi A., Maio R.C., Marino F., Cosentino M., Guasti L., Rasini E., Legnaro<br />

M., Colombo C., Cereda E., Cimpanelli M., Castiglioni L., Tozzi M. 1 , Castelli P. 1 , Venco A.,<br />

Lecchini S.<br />

Department of Clinical Me<strong>di</strong>cine, Section of Experimental and Clinical Pharmacology and<br />

1 Department of Surgical Sciences, University of Insubria, Varese, Italy<br />

pag_dx.indd 1 30/05/2007 5.55.49


218. Atorvastatin and minocycline, effective combination in experimental autoimmune<br />

encephalomyelitis<br />

Luccarini Ilaria a , Biagioli T. b , Ballerini C. b , Biamonte F. c , Bellucci A. d , Fiorentini A. a , Casamenti<br />

F. a<br />

a Dept of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. b Dept<br />

of Neurology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. c Dept of<br />

Neuroscience, University Campus Bio-Me<strong>di</strong>co of Rome, Italy. d Dept Biomed. and Biotechnol.<br />

Sci., University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br />

219. IL-2 induces an altered CD4/CD8 ratio of splenic T lymphocytes from transgenic<br />

mice overexpressing the glucocorticoid-induced protein GILZ<br />

Pozzesi Nicola, Riccar<strong>di</strong> C., Delfino D.V.<br />

Section of Pharmacology, Toxicology and Chemotherapy, Department of Clinical and<br />

Experimental Me<strong>di</strong>cine, University of Perugia Me<strong>di</strong>cal School, Perugia, Italy<br />

220. Out of frame BCR-ABL fusion peptides as targets of the immunotherapy in chronic<br />

myelogenous leukemia<br />

Casnici Clau<strong>di</strong>a, Crotta K., Lattuada D., Mastrotto C., Volpe G. * , Panuzzo C.*, Kuka M.*,<br />

Saglio G.*, Marelli O.<br />

Department of Pharmacology, School of Me<strong>di</strong>cine, University of Milan, Milan, Italy;<br />

*Department of Clinical and Biological Science, University of Turin, Turin, Italy<br />

140<br />

221. Expression of the ang II type 1 receptor on human CD4 + CD25 +hi regulatory T cells<br />

Rasini Emanuela, Marino F., Guasti L., Ferrari M., Legnaro M. Schembri L., Venco A., Lecchini<br />

S., Cosentino M.<br />

Department of Clinical Me<strong>di</strong>cine, University of Insubria, Varese, Italy<br />

222. Effect of <strong>di</strong>fferent mentha piperita varieties on proliferation and cytokine production<br />

in human peripheral blood mononuclear cells<br />

Carcano Elena, Cosentino M., Bombelli R., Luini A., Marino F., * Colombo M. L., # Conti A.,<br />

Lecchini S.<br />

Dept. Clinical Me<strong>di</strong>cine, Sect. Clin. Exp. Pharmacology, University of Insubria, Varese, I,<br />

* Dept. Pharm. Sci. Technol., University of Turin, I, and # Alpine Foundation for Life Sciences,<br />

Olivone, CH<br />

223. Mo<strong>di</strong>fied -galactosyl ceramide analogs for stimulating iNKT cells: a<br />

pharmacological characterization<br />

Fallarini Silvia 1 , Panza L. 1 , Compostella F. 2 , Ronchetti F. 2 , De Libero G. 3 , Lombar<strong>di</strong> G. 1<br />

1 DISCAFF Department, University of “Piemonte Orientale”, Novara, Italy ; 2 Department of<br />

Chemistry, Biochemistry and Biotechnology for Me<strong>di</strong>cine, University of Milano, Milano, Italy;<br />

3 Experimental Immunology, Department of Research, University Hospital, Basel, Switzerland<br />

224. A tuscan olive oil extract inhibits Nuclear Factor-Kappa B activation in<br />

monocyte/macrophages from healthy donors<br />

Bardelli Clau<strong>di</strong>o 1 , Gunella G. 1 , Amoruso A. 1 , Brunelleschi S. 1 , Romani A. 2 , Ieri F. 2 , Coinu R. 3 ,<br />

Franconi F. 3<br />

1 Dept. Me<strong>di</strong>cal Sciences, University “A. Avogadro”, Novara (Italy); 2 Dept. Pharmacological<br />

Chemistry, University of Florence (Italy);<br />

3 Center of Excellence for Biotechnology<br />

Development and Bio<strong>di</strong>versity Research, University of Sassari (Italy)<br />

pag_sx.indd 1 30/05/2007 5.56.38


Farmacologia clinica e sperimentazione clinica dei farmaci<br />

Poster 225 – 240<br />

225. Quality of life of pe<strong>di</strong>atric patients with attention deficit hyperactivity <strong>di</strong>sorder and<br />

oppositive defiant <strong>di</strong>sorder: an italian double-blind placebo-controlled study with<br />

atomoxetine<br />

Dell’Agnello Grazia 2 , Curatolo P. 1 , Mancini F. 2<br />

1 Neuropsychiatria Infantile Clinica Sant’Alessandro, Rome, Italy; 2 Eli Lilly Italia<br />

226. Evening and early morning administration of atomozetine in ADHD children: a<br />

comparison<br />

Dell’Agnello Grazia 4 , Kelsey D. 1 , Sutton V. 1 , Lewis D. 2 , Schuh K. 1 ; Sumner C. 1 , Quintana H. 3 ,<br />

Fre<strong>di</strong>ani S. 4 , Rossi A. 4<br />

1 Lilly Research Laboratories,In<strong>di</strong>anapolis,IN;<br />

2 Monarch Me<strong>di</strong>cal Research,Norfolk,VA;<br />

3 Louisiana State University Health Science Center,New Orleans,LA; 4 Eli Lilly Italia<br />

227. Safety and tolerability of duloxetine in the treatment of major depressive <strong>di</strong>sorder:<br />

analysis of pooled data from eight placebo-controlled clinical trials<br />

Mancini Michele, Barraco A., Rossi A.<br />

Eli Lilly Italia S.p.A.<br />

228. The new antidepressant duloxetine: car<strong>di</strong>ovascular effects<br />

Mancini Michele, Barraco A., Rossi A.<br />

Eli Lilly Italia S.p.A.<br />

229. The management of bipolar mania: a national survey of baseline data from the<br />

emblem study<br />

Mancini Michele 2 , Bellantuono C. 1 , Rossi A. 2 , Barraco A. 2 , Goetz I. 3 , for the Italian EMBLEM<br />

study group<br />

1 Department of Me<strong>di</strong>cine and Public Health, Section of Psychiatry and Clinical Psychology,<br />

University of Verona, Italy; 2 Eli Lilly Italia S.p.A. for the Italian EMBLEM study group; 3 Eli Lilly<br />

and Company, Windlesham, UK<br />

141<br />

230. European mania in bipolar longitu<strong>di</strong>nal evaluation of me<strong>di</strong>cation (emblem) study:<br />

results of the acute 12-week phase in Italy by regional location (north, centre and<br />

south)<br />

Mancini Michele 1 , Rossi A. 1 , Barraco A.1, Goetz I. 2 , for the Italian EMBLEM study group<br />

1 Eli Lilly Italia S.p.A.; 2 Eli Lilly and Company, Windlesham, UK<br />

231. Effectiveness of antipsychotic treatment in outpatients with schizophrenia: 36-<br />

month results from the schizophrenia outpatients health outcomes (SOHO) study<br />

Scatigna Marco (3) , Novick Diego (1) , Haro Josè M. (2) , Brown James (1) , Suarez Diego (2) , Rossi<br />

Andrea (3) , Fre<strong>di</strong>ani Sonia (3) , Ratcliffe Mark C. (1) , and the SOHO Study Group (4)<br />

(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca e sviluppo, San Joan de Deu-SSM,<br />

Sant Boi, Barcellona, Spagna (3) Eli illy Italia S.p.A. (4) Alonso J (SP), Gasquet I (FR), Haro JM<br />

(SP) Jones PB (UK), Knapp M (UK), Lepine JP (FR), Naber D (DE), Slooff CJ (NL)<br />

232. Tolerability of outpatient antipsychotic treatment: 36-month results from the<br />

european schizophrenia outpatients health outcomes (soho) study<br />

Scatigna Marco (5) , Novick D. (1) , Haro Josè M. (2) , Suarez D. (2) , Bushe C. (3) , Lepine A. (4) , Rossi<br />

A. (5) , Fre<strong>di</strong>ani S. (5) , the SOHO Study Group (6)<br />

(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca e sviluppo, San Joan de Deu-SSM,<br />

Sant Boi, Barcellona, Spagna (3) Eli Lilly and Company, Basingstoke, UK; (4) Hôpital Fernand<br />

Widal Parigi Cedex 10 (5) Eli Lilly Italia S.p.A. (6) Alonso J (SP), Gasquet I (FR), Haro JM (SP)<br />

Jones PB (UK), Knapp M (UK), Lepine JP (FR), Naber D (DE), Slooff CJ (NL)<br />

pag_dx.indd 1 30/05/2007 5.57.26


233. Therapeutic monitoring of clozapine, ABCB1 genotyping and response to treatment<br />

in psychotic patients<br />

Lastella Marianna*, Consoli G.°, Amatori F.*, Catena M.°, Ciapparelli A.°, Ciofi L.*, Golia F.°,<br />

Carmassi C.°, Danesi R.*, Dell’Osso L.°, Del Tacca M.*, Di Paolo A.*<br />

*Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />

Pisa; °Psychiatric Clinic, Department of Psychiatry, Neurobiology, Pharmacology and<br />

Biotechnology, University of Pisa, Pisa<br />

234. Essential tremor is responsive to combined topiramate and declorazepam treatment<br />

Gallelli Luca 2 , Siniscalchi A. 1 , Borner Perrone I. 2 , Davoli A. 2 , De Sarro G. 2<br />

1 Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy;<br />

2 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />

Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Catanzaro, Italy<br />

235. Therapeutic drug monitoring of gentamicin in newborns: our experience<br />

Martinelli Valentina, Serpi A.*, Carta P., Fanos V.*, Del Zompo M., Testa M.*<br />

Section of Clinical Pharmacology, Department of Neurosciences “B.B. Bro<strong>di</strong>e”, University of<br />

Cagliari; *Institute of Neonatal Pathology and Intensive Therapy, University of Cagliari<br />

142<br />

236. Phase II marker lesion study of 6-week intravesical gemcitabine instillation in<br />

patients with low-risk superficial bladder cancer<br />

Russo Francesca 6 , Brausi M. 1 , Giussani L. 2 , Altieri V. 3 , Rigatti P. 4 , Gontero P. 5 , Bertelli L. 6 ,<br />

Rossi A. 6 , Langer F. 7 , Bono A. 2<br />

1 Divisione <strong>di</strong> Urologia AUSL, Modena, 2 Divisione <strong>di</strong> Urologia Ospedale <strong>di</strong> Circolo e Fondazione<br />

Macchi, Varese, 3 Clinica Urologia Azienda Universitaria Policlinico Federico II , Napoli,<br />

4 Clinica Urologia Università Vita e Salute, Ospedale S. Raffaele, Milano, 5 Clinica <strong>di</strong> Urologia<br />

Ospedale Maggiore della Carità, Novara, 6 Eli Lilly Italia; 7 Eli Lilly EuMed<br />

237. Comparison between <strong>di</strong>fferent topical hypotensive drugs in two experimental<br />

models of glaucoma in the rabbit<br />

*Fabrizi Francesca, °Giambene B., °Galassi G., *Uliva C., § Ongini E., *Masini E.<br />

*Department of Preclinical and Clinical Pharmacology; University of Florence;°Department of<br />

Oto-neuro-ophthalmological Sciences, University of Florence and § NicOx Research Institute,<br />

Milan, Italy<br />

238. Plasma levels of arginine and lactate in rehabilitation patients with spinal cord<br />

injury and pressure ulcers<br />

Verri Manuela*, Aquilani R.^, Boschi F.*, Dossena M.*, Iadarola P.°, Viglio S.°, Pastoris O.*<br />

*Department of Physiological & Pharmacological Sciences; °Department of Biochemistry “A.<br />

Castellani”, University of Pavia, Pavia, Italy; ^IRCCS “S. Maugeri” Foundation, Montescano,<br />

Italy<br />

239. Sildenafil citrare versus Tadalafil for ED treatment: preference of italian patients<br />

and reasons of their choice<br />

Gentilella Raffaella 6 , Fusco F., Lembo A. 1 , Ludovico G.M. 2 , Pirozzi Farina F. 3 , Montorsi F. 4 ,<br />

Menchini Fabris F. 5 , Sicuteri R. 6 , Rossi A. 6 , Mirone V.<br />

Clinica Urologica, Università Federico II, Napoli; 1 Div. Urologia, Ospedali Riuniti <strong>di</strong> Bergamo;<br />

2 Unità <strong>di</strong> Urologia Operativa, Ospedale Civile, Monopoli, Bari; 3 Università Di Sassari, Clinica<br />

Urologica; 4 Reparto <strong>di</strong> Urologia, Ospedale S. Raffaele, Milano; 5 Unità <strong>di</strong> Andrologia, Università<br />

<strong>di</strong> Pisa, Pisa; 6 Eli Lilly Italia<br />

240. The magnitude of inhibitory drug interactions is dependent on liver functional status<br />

Pegoraro Paola 1 , De Martin S. 1 , Orlando R. 2 , Palatini P. 1<br />

1 Department of Pharmacology and Anaesthesiology, and of 2 Me<strong>di</strong>cal and Surgical Sciences<br />

University of Padova, Italy<br />

pag_sx.indd 1 30/05/2007 5.58.25


Farmacovigilanza, farmacoepidemiologia e farmacoeconomia<br />

Poster 241 – 253<br />

241. Gabapentin-induced rhabdomyolysis: a case report<br />

Tuccori Marco 1,2 , Lombardo G. 2 , Lapi F. 1,4 , Vannacci A. 1,4 , Blan<strong>di</strong>zzi C. 1,4 , Mugelli A. 1,4 , Del<br />

Tacca M. 1,2<br />

1 Tuscan Regional Center for Pharmacovigilance;<br />

2 Division of Pharmacology and<br />

Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of Pisa – Pisa, Italy; 3 Intensive<br />

Care Unit - Hospital of Empoli, Florence – Italy; 4 Department of Preclinical and Clinical<br />

Pharmacology - University of Florence, Florence – Italy<br />

242. Anticoagulants and drugs at interaction risk<br />

Alacqua Marianna 1 , Trifirò G. 1,4 , Moretti S. 3 , Tari M. 3 , Galdo M. 3 , Tari U. 3 , Caputi A.P. 1,4 ,<br />

UVEC group 3 , ArcoracI V. 1<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Pharmacology Unit,<br />

University of Messina, Italy - 2 Division of Child Neurology and Psychiatry, University of<br />

Messina, Italy - 3 “Caserta 1” Local Health Service, Caserta, Italy - 4 IRCCS Centro Neurolesi<br />

"Bonino-Pulejo", Messina, Italy<br />

243. Vigilance system for undesirable effects of cosmetic products (cosmetovigilance) in<br />

Europe<br />

Sportiello Liberata 1 , Sautebin L. 1,2<br />

1 Department of Experimental Pharmacology, 2 Pharmacoeconomic and Pharmacoutilization<br />

Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy<br />

244. Notification of undesirable effects of cosmetic products by pharmacists and<br />

dermatologists: a pilot project<br />

Sautebin Li<strong>di</strong>a<br />

Department of Experimental Pharmacology, Pharmacoeconomic and Pharmacoutilization<br />

Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy<br />

143<br />

245. Gender <strong>di</strong>fference in adverse drug reactions: analysis of spontaneous reports of an<br />

italian interregional database (GIF)<br />

Salvo F. (1) , Cutroneo P.M. (1) , Meneghelli I. (2) , Motola D. (3) , Del Tacca M. (4) , Ros B. (5) , Capuano<br />

A. (6) , Leoni O., Polimeri G. (1)<br />

(1) Dep. Clin Experim Med and Pharmacol, University of Messina, Italy - (2) Clinical<br />

Pharmacology Unit, University of Verona, Italy - (3) Interuniversity Research Centre for<br />

Pharmacoepidemiology, University of Bologna, Italy - (4) Division of Pharmacology and<br />

Chemotherapy, University of Pisa, Italy; (5) Pharmaceutical Service of Friuli Venezia Giulia<br />

Health Department, Trieste, Italy - (6) Department of Experimental Me<strong>di</strong>cine, Second University<br />

of Naples, Italy - (7) Lombardy Centre of Pharmacovigilance, Milan, Italy<br />

246. Gender and age-related drug prescription patterns in the varese local health<br />

authority<br />

Leoni Olivia 1 , Banfi F. 2 , Soma R. 1 , Manfre<strong>di</strong> L. 1 , Oria C. 1 , Roi C. 1<br />

1 PAC Department, Varese Local Health Authority, Italy; 2 Health Managed, Varese Local Health<br />

Authority, Italy<br />

247. The pharmacological consultation service as a valid tool for developing a correct<br />

drug approach: "the Poppers' case"<br />

Stochino M. Erminia, Asuni C., Carta P., Del Zompo M.<br />

Drug Information Centre, Section of Clinical Pharmacology, Department of Neurosciences<br />

“B.B. Bro<strong>di</strong>e”, University of Cagliari<br />

pag_dx.indd 1 30/05/2007 5.59.06


248. Adverse reactions to contrast me<strong>di</strong>a: an analysis from spontaneous reporting data<br />

Paola Cutroneo 1 , Polimeri G. 1,2 , Curcuruto R. 1 , Russo A. 1 , Calapai G. 1 , Caputi A.P. 1<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />

University of Messina, Italy; 2 Istituto <strong>di</strong> Ricovero e Cura a Carattere Scientifico (IRCCS)<br />

Centro Neurolesi "Bonino-Pulejo," Messina, Italy<br />

249. Regional surveillance of emergency department visits for outpatient adverse drug<br />

events<br />

Gallo Mariapina, Ferrante L., Illiano M.L., Russo F., Annibale R., Filippelli A., Rossi F.,<br />

Captano A.<br />

Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “Leonardo Donatelli”. Center<br />

of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Me<strong>di</strong>cine and Surgery, Second<br />

University of Naples, Italy<br />

250. Pharmacovigilance teaching in the european faculties of pharmacy<br />

Rossi Antonietta 1 , Pergola C. 1 , Sautebin L. 1,2<br />

1 Department of Experimental Pharmacology, 2 Pharmacoeconomic and Pharmacoutilization<br />

Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy.<br />

144<br />

251. Promoting continuing education in pharmacovigilance: the experience of<br />

"Pharmasearch", a network of general practitioners reporting adverse drug<br />

reactions<br />

Catania Maria A. 1 , Salvo F. 1 , Oteri A. 1 , Polimeni G. 1,5 , Russo A. 1 , Giustini Saffi E. 2 , Sessa A. 2 ,<br />

Tuccori M. 3 , Martelli A. 4 , Del Tacca M. 3 , Caputi A. P. 1,5<br />

1 University of Messina; 2 Area Pharmasearch, SIMG;<br />

3 University of Pisa;<br />

4 University of<br />

Genova; 5 IRCCS Neurolesi “Bonino-Pulejo”, Messina<br />

252. The blink project: a new biome<strong>di</strong>cal researchers' database (www.doyoublink.net)<br />

Biggio Giovanni 3 , Busconi P. 1 , Ferranti S. 2 , Ceserani I. 3 , Pistotti V. 4 , Casale F. 3 , Caglioti L. 5 ,<br />

Garattini S. 4<br />

1 Promotore, Fondazione Schering, Italy – 2S Sviluppo tecnico database, New! S.a.s., Milano,<br />

Italy; 3 Società Italiana <strong>di</strong> Farmacologia, Milano, Italy - 4 Istituto <strong>di</strong> Ricerche Farmacologiche<br />

“Mario Negri”, Italy - 5 Università "La Sapienza", Roma, Italy<br />

253. On parenteral formulations and golden standards for quality and safety<br />

a Naccari C., b Giovinazzo C., a Saija A., a Tomaino A.<br />

a Dept. Farmaco-Biologico, Faculty of Pharmacy, University of Messina, Contrada Annunziata,<br />

98168 Messina, Italy; b Faculty of Pharmacy, University of Messina, Contrada Annunziata,<br />

98168 Italy<br />

Farmacognosia e fitoterapia: aspetti sperimentali e clinici<br />

Poster 254 – 265<br />

254. Central effects of a new secoisopimarane <strong>di</strong>terpenoid from aerial parts of Salvia<br />

cinnabarina<br />

Maione Francesco 1,2 , Colucci M. 2 , Bisio A. 3 , Romussi G. 3 , Pieretti S. 2 , Di Giannuario A. 2 , Maria<br />

C. Bonito M.C. 1,2 , Mascolo N. 1<br />

1 Department of Experimental Pharmacology, University of Naples “Federico II, Naples;<br />

2 Department of Drug Research and Evaluation, Italian National Institute of Health, Rome;<br />

3 Department of Chemistry and Pharmaceutical Technology and Alimentary, University of<br />

Genoa, Genoa<br />

255. In vitro antioxidant activity of aged extracts of some italian spontaneous Allium<br />

species<br />

Nencini Cristina, Micheli L., Giorgi G., Franchi G.G.<br />

Department of Pharmacology “Giorgio Segre”, University of Siena<br />

pag_sx.indd 1 30/05/2007 6.00.06


256. Effect of Allium neapolitanum on liver injury induced by ethanol in rats<br />

Nencini Cristina, Franchi G. G., Giorgi G., Micheli L.<br />

Department of Pharmacology “Giorgio Segre”, University of Siena<br />

257. Antioxidant properties of infusions from leaves and inflorescences of Achillea<br />

millefolium ssp. collina B. By use of chemical and biological assays<br />

Bombelli R. 1 , Luini A. 1 , Giorgi A. 2 , Licheri G. 2 , Carcano E. 1 , Marino F. 1 , Cosentino M. 1 ,<br />

Cocucci M. 2 , Lecchini S. 1<br />

1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica, Sezione <strong>di</strong> Farmacologia Sperimentale e Clinica, Università<br />

<strong>degli</strong> <strong>Stu<strong>di</strong></strong> dell’Insubria, Varese and 2 Dipartimento <strong>di</strong> Produzione Vegetale, Università <strong>degli</strong><br />

<strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano, Milano<br />

258. In vitro antioxidant, antimutagen and anti-inflammatory activity of extracts and<br />

stilbenes from Glycyrrhiza glabra leaves<br />

1 Cristani M., 1 Saija A., 1 D’arrigo M., 1 Naccari C., 2 Ruberto G., 2 Bion<strong>di</strong> D.D., 1 Trombetta D.<br />

1 Dept. Farmaco-Biologico, School of Pharmacy, University of Messina, Italy - 2 CNR Institute of<br />

Biomolecular Chemistry - Catania, Valverde, Catania, Italy<br />

259. Protective effect of Hypericum perforatum in zymosan-induced multiple organ<br />

dysfunction syndrome<br />

1 De Sarro Angelina, 1,2 Mazzon E., 1,2 Di Paola R., 1 Muià C., 1,2 Genovese T., 2 Bramanti P.,<br />

3 Esposito E., 4 Menegazzi M., 3 Meli R., 4 Suzuki H., 1,2 Cuzzocrea S.<br />

1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />

University of Messina, Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy;<br />

3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”, Napoli, Italy;<br />

4 Department of Neuroscience and Vision, University of Verona, Verona, Italy<br />

145<br />

260. Inhibition of human cAMP phospho<strong>di</strong>esterases as a mechanism of the spasmolytic<br />

effect of Matricaria recutita L. water extract<br />

Dell’Agli Mario, Dal Cero E., Maschi O., Bosisio E.<br />

Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Italy<br />

261. Phenylpropanoid rich essential oils as potential antithrombotics endowed with<br />

gastroprotective effects<br />

Tognolini Massimiliano 1 , Barocelli E. 1 , Bertoni S. 1 , Impicciatore M. 1 , Bruni R. 2 , Ballabeni V. 1<br />

1 Dept of pharmacological, biological and applied chemical sciences. University of Parma. Viale<br />

Usberti 27/a, 43100 Parma, Italy; 2 Dept of evolutionary and functional biology. University of<br />

Parma. Viale Usberti 11/a, 43100 Parma, Italy<br />

262. Biological activity of bergamot peel extracts (Citrus bergamia Risso)<br />

Trombetta D., D’Arrigo M., Ginestra G., Arcoraci T., Mandalari G., Saija A., Cristani M.<br />

Dept. Farmaco-Biologico, School of Pharmacy, University of Messina - Vill. SS. Annunziata<br />

98168 Messina, Italy<br />

263. Evidence to implicate phospho-Akt (p-Akt) in the mechanisms underlying<br />

neuroprotection afforded by the essential oil of bergamot against excitotoxicity in<br />

vitro<br />

Maida Simona 1 , Fratto V., Navarra M. 1 , Bagetta G. 2 , Corasaniti M.T. 1<br />

1 Department of Pharmacobiological Sciences, University “Magna Graecia” of Catanzaro,<br />

Catanzaro, Italy; 2 Department of Pharmacobiology and University Centre of Adaptive<br />

Disorders and Headache (UCADH), section of Neuropharmacology of Normal and Pathological<br />

Neuronal Plasticity, University of Calabria, Rende (CS), Italy<br />

pag_dx.indd 1 30/05/2007 6.00.45


264. The protective effect of bergamot oil non volatile fraction on LOX-1 expression in<br />

balloon injury-related neointima formation<br />

Sacco Iolanda 1 , Palma E. 1 , Sculco F. 1 , Colica C. 1 , Visalli V. 1 , Muscoli S. 3 , Ragusa S. 1 ,<br />

Mondello L. 4 , Rotiroti D. 1 , Romeo F. 3 , Mollace V. 1,2<br />

1 Faculty of Pharmacy, University “Magna Graecia” of Catanzaro, Italy; 2 San Raffaele Pisana<br />

IRCCS, Rome, Italy; 3 Chair of Car<strong>di</strong>ology, University of Rome “Tor Vergata”, Rome, Italy;<br />

4 Faculty of Pharmacy, University of Messina, Italy<br />

265. Vascular activity of isolates from the Hyacinthaceae of south Africa<br />

Maida Simona 1 , Fratto V., Navarra M. 1 , Bagetta G. 2 , Corasaniti M.T. 1<br />

1 Department of Pharmacobiological Sciences, University “Magna Graecia” of Catanzaro,<br />

Catanzaro, Italy; 2 Department of Pharmacobiology and University Centre of Adaptive<br />

Disorders and Headache (UCADH), section of Neuropharmacology of Normal and Pathological<br />

Neuronal Plasticity, University of Calabria, Rende (CS), Italy<br />

Farmacogenetica, farmacogenomica e terapia genica<br />

Poster 266 – 280<br />

266. Olymorphisms of the ABCB1 gene pre<strong>di</strong>ct drug resistance in epileptic patients<br />

Lastella Marianna*, Danesi R.*, Cascio E.*, Jensen S. § , Iu<strong>di</strong>ce A. § , Murri L. § , Del Tacca M.*,<br />

Di Paolo A.*<br />

*Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine;<br />

§ Division of Neurology, Department of Neurosciences - University of Pisa<br />

146<br />

267. Herpes simplex vectors expressing FGF-2 and BDNF prompt neuronogenesis and<br />

exert <strong>di</strong>sease-mo<strong>di</strong>fying effects in a model of temporal lobe epilepsy<br />

Mazzuferi Manuela 1 , Para<strong>di</strong>so B. 1 , Marconi P. 1 , Zucchini S. 1 , Berto E. 1 , Binaschi A. 1 , Bozac A. 1 ,<br />

Buzzi A. 1 , Magri E. 1 , Navarro Mora G. 2 , Ro<strong>di</strong> D. 1 , Volpi I. 1 , Fabene P.F. 2 , Marzola A. 1 ,<br />

Manservigi R. 1 , Simonato M. 1<br />

1 University of Ferrara, 2 University of Verona, Italy<br />

268. Alzheimer's <strong>di</strong>sease: association study between response to cholinesterase<br />

inhibitors and can<strong>di</strong>date genes in a sar<strong>di</strong>nian sample<br />

Squassina Alessio 1 , Congiu D. 1 , Manconi F. 1 , Putzu P.F 2 , Chillotti C. 1 , Del Zompo M. 1 , Piccar<strong>di</strong><br />

M. 1<br />

1 Unit of Clinical Pharmacology, Department of Neurosciences ‘‘B. B. Bro<strong>di</strong>e’’, University of<br />

Cagliari, 2 Division of Geriatrics, Local Health Agency 8, Cagliari, Italy<br />

269. Impact of CYP3A4 and CYP3A5 polymorphisms on clinical outcome of donepezil in<br />

Alzheimer's <strong>di</strong>sease patients<br />

Paoletti T. 1 , Scordo M.G. 2 , Miglio G. 1 , Villa M.L. 3 , Dahl M.L. 2 , Lombar<strong>di</strong> G. 1<br />

1 DISCAFF Department, University of “Piemonte Orientale Amedeo Avogadro”, Novara, Italy;<br />

2 Department of Me<strong>di</strong>cal Sciences, Clinical Pharmacology, Uppsala University Hospital,<br />

Uppsala, Sweden; 3 Geriatric Clinical Unit, “ Ospedale Maggiore della Carità”, Novara, Italy<br />

270. Role of polymorphisms of the UGT1A9 gene in comt inhibitor-induced hepatotoxicity<br />

in parkinson's <strong>di</strong>sease: a clinical study<br />

1 Ferrari Marco, 1 Cosentino M., 1 Marino F., 1 Bono G., 2 Martignoni E., 3,4 Nappi G., 1 Lecchini S.<br />

1 Dept. Clin. Med., University of Insubria, Varese, 2 Dept. Med. Sci., University of Piemonte<br />

Orientale “Amedeo Avogadro”, Novara and Dept. Neurorehabil. Mov. Disord., “Salvatore<br />

Maugeri” Foundation, Scientific Institute of Veruno, NO, 3 Dept. of Neurol. Otorhinolaryngol.,<br />

University “La Sapienza”, Rome, and 4 I.R.C.C.S. C. Mon<strong>di</strong>no, Pavia, Italy<br />

pag_sx.indd 1 30/05/2007 6.01.35


271. Genetic polymorhisms of serotonin transporter and monoamine oxidase; and<br />

response to SSRI antidepressant drugs in terminal cancer patients<br />

Schillani Giulia, Capozzo M., Conte A.M., De Vanna M., Giral<strong>di</strong> T.<br />

Department of Biome<strong>di</strong>cal Sciences, University of Triest<br />

272. Lithium response: association study with can<strong>di</strong>date genes<br />

Manchia Mirko, Squassina A., Lampus S., Ardau R., Chillotti C., Del Zompo M., Severino G.<br />

Section of Clinical Pharmacology, Department of Neurosciences “B.B. Bro<strong>di</strong>e”, University of<br />

Cagliari<br />

273. Pharmacogenomics and triptans: a pilot study of association between clinical<br />

response to rizatriptan and some can<strong>di</strong>date genes<br />

Asuni Carlo, Stochino M.E., Congiu D., Cherchi A., Piccar<strong>di</strong> M. P., Del Zompo M.<br />

Headache Centre, Section of Clinical Pharmacology, Department of Neurosciences “B.B.<br />

Bro<strong>di</strong>e”, University of Cagliari<br />

274. Synergistic cytotoxicity of oxaliplatin and pemetrexed in colon cancer cells: cellular<br />

and molecular mechanisms<br />

Nannizzi Sara, Giovannetti E., Mey V., Ricciar<strong>di</strong> S., Del Tacca M., Danesi R.<br />

Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />

Pisa<br />

275. Molecular mechanisms underlying the synergistic interaction of the EGFR tyrosine<br />

kinase inhibitor erlotinib with the multitargeted antifolate pemetrexed in non-small<br />

cell lung cancer cells<br />

Giovannetti Elisa 1,2 , Smid K. 1 , Mey V. 2 , Tekle C. 1 , Nannizzi S. 2 , Rodriguez J.A 1 , Ricciar<strong>di</strong> S. 2 ,<br />

Del Tacca M. 2 , Giaccone G. 1 , Danesi R. 2 , Peters Godefridus J 1<br />

1 Dept. Me<strong>di</strong>cal Oncology, VU University Me<strong>di</strong>cal Center, Amsterdam, The Netherlands; 2 Dept.<br />

Internal Me<strong>di</strong>cine, Div. Pharmacology and Chemotherapy, University of Pisa, Italy<br />

147<br />

276. Pharmacogenetic evaluation of Aurora A kinase in colorectal cancers<br />

Amatori Federica Maria*, Boldrini L § , Di Paolo A*, Lastella M*, Fontanini G § , Del Tacca M*,<br />

Danesi R*.<br />

*Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine; § Division of<br />

Pathology, Department of General Surgery, University of Pisa<br />

277. Epigenetic mechanisms of sensitivity to irinotecan in colorectal cancer cell lines<br />

Crea Francesco, Giovannetti E., Mey V., Nannizzi S., Ricciar<strong>di</strong> S., Danesi R., Del Tacca M.<br />

Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />

Pisa, Pisa, Italy<br />

278. Genetic polymorphisms in DNA repair genes and their impact on susceptibility to<br />

multiple myeloma<br />

Angelini Sabrina 1 , Cantelli-Forti G. 1 , Terragna C. 2 , Renzulli M. 2 , Cavo M. 2 , Hrelia P. 1<br />

1 Department of Pharmacology, University of Bologna; 2 Institute of Haematology and Me<strong>di</strong>cal<br />

Oncology “Seragnoli”, University of Bologna<br />

279. Genetic polymorphism of bleomycin hydrolase: a new biomarker for human<br />

mutagen sensitivity<br />

Maffei Francesca 1 , Carbone F. 1 , Angelini S. 1 , Cantelli Forti G. 1 , Norppa Hannu 2 , Hrelia P. 1<br />

1 Department of Pharmacology, University of Bologna, Via Irnerio 48 40126 Bologna, Italy;<br />

2 Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FI-00250 Helsinki, Finland<br />

pag_dx.indd 1 30/05/2007 6.02.14


280. DNA vaccine strategy against chronic B-cell lymphoma: anti-i<strong>di</strong>otypic CDR3<br />

vaccination<br />

Schirru Cristina 1 , Maullu C. 1 , Deidda F. 1 , Rinal<strong>di</strong> M. 3 , Signori E. 2,3 , Massi E. 2 , Chiarella P. 1,2 ,<br />

Marelli O. 4 , Tonon G. 1 , Fazio V.M. 2,3<br />

1 Bioker S.r.l. Polaris Loc.piscinamanna Pula (CA); 2 CIR, Section of Molecular Me<strong>di</strong>cine and<br />

Biotechnology, University "Campus Bio-Me<strong>di</strong>co", Rome, Italy; 3 Institute of Neurobiology and<br />

Molecular Me<strong>di</strong>cine, CNR Rome, Italy; 4 Dipartimento Di Farmacologia, Chemioterapia E<br />

Tossicologia Me<strong>di</strong>ca, Università <strong>di</strong> Milano<br />

148<br />

pag_sx.indd 1 30/05/2007 6.03.02


38<br />

pag_sx.indd 1 30/05/2007 7.14.27


Aas M 131<br />

Abbadessa G 108<br />

Abbate R 120<br />

Abbate M 43<br />

Abbracchio M 35, 126<br />

Abbruzzese A 128<br />

Abdelrahman M 133<br />

Accomazzo MR 102<br />

Acquadro E 88<br />

Acquas E 96, 130<br />

Adami M 98<br />

Adamo E 58, 135<br />

Adcock I<br />

Adornetto A<br />

Agnati LF 30<br />

Agnoletto L 78, 117<br />

Agostini M 103,<br />

Agostini S 98, 99, 135<br />

Agresta A 129, 130<br />

Agretti P 113<br />

Agrusa A 138<br />

Aguglia E 28, 38, 66<br />

Aiello A<br />

Aimola P 109<br />

Akpan V 137<br />

Alacqua M 111, 124, 143<br />

Alaimo A 104<br />

Albanese A 128<br />

Albini A 81<br />

Alboni S 62, 85<br />

Alcaro S 136<br />

Alderighi D 104<br />

Alemà GS 123, 126<br />

Alfieri A 134<br />

Alicandri C 106<br />

Aliferopulos H 111<br />

Allegretti M 138<br />

Allegrini G 138<br />

Alloisio S 81, 112<br />

Almairac R 120<br />

Altamura CA 28, 38<br />

Altavilla D 54, 58, 101, 117,<br />

126, 127 , 135, 136<br />

Altea S 130<br />

Altieri V 142<br />

Ama<strong>di</strong>o M 98<br />

Ama<strong>di</strong>o S<br />

Amantea D 43<br />

Amato D 86, 93<br />

Amatori FM 59, 142, 147<br />

Ambrosio C 78<br />

Amici A 59<br />

Amoroso S 31, 37, 115<br />

Amoruso A 35, 37, 140<br />

Anania V 108<br />

Andersen SJ 93<br />

Andre E 131, 132<br />

Andreassi MG<br />

Andretta F 127<br />

Angeli A 58<br />

Angelini S 147<br />

Angeloni C 88<br />

Angioni MM 88<br />

Angius F 130<br />

Anichini R 100<br />

Annibale R 144<br />

Annunziato L 35, 63, 77, 81, 110,<br />

126<br />

Antenucci G 113<br />

Antonelli T 31<br />

Antonioli L 98, 134<br />

Antonuccio P 101<br />

Anzellotti P 84, 102<br />

Apicella C 102<br />

Appen<strong>di</strong>no G 47<br />

Aquaro S<br />

Aquilani R 84<br />

Aquino RP 108<br />

Arbitrio M 87, 93<br />

Arcieri P 57, 90<br />

Arcone R 93, 128<br />

Arcoraci T 145<br />

Arcoraci V 107, 124, 143<br />

Ardau R 106, 147<br />

Argiolas A 101, 130<br />

Armida M 82<br />

Armocida G 121<br />

Arnabol<strong>di</strong> L 121<br />

Arnoletti E 100, 135, 136<br />

Aronica E 126<br />

Ascolani A 116<br />

Assaretti AR<br />

Asuni C 143, 147<br />

Autore G 83, 108, 119, 120<br />

Avallone R 121, 136<br />

Avanzini G 117<br />

Aviello G 58<br />

Ayrol<strong>di</strong> E 58<br />

Azad S 118<br />

Azzena G<br />

Babini E 115<br />

Baccini G 118<br />

Bachis E 76<br />

Bacosi E 96<br />

Badalamenti G 138<br />

Bader G 48<br />

Bader M 99<br />

Ba<strong>di</strong>ani A 93, 96, 97<br />

Badura A<br />

Baetta R 121<br />

Bagetta G 43, 44, 65, 145, 146<br />

Baggio G 103, 139<br />

Baigent C 29<br />

Baiula M 58, 137<br />

Bajetto A 79<br />

Balduini W 65, 127<br />

Balestra B 135<br />

Balestrieri E 28, 116<br />

Ballabeni V 118, 134, 145<br />

Ballerini P 35<br />

Ballerini C 140<br />

Banchelli G 107<br />

Banfi F 143<br />

Bani D 132<br />

Bano F 107<br />

Barabino A 109<br />

Barabino E 36<br />

Baragli A 100,135<br />

Baral<strong>di</strong> M 58, 82, 101, 102, 121,<br />

136, 137<br />

Baral<strong>di</strong> PG 28, 37, 89<br />

Barberi L 128<br />

Barberis A 59, 104<br />

Barbierato M 78<br />

Barbieri A 113, 117<br />

Barbieri F 79<br />

Barbieri R 112<br />

Barbieri M 122<br />

Barbieri S 54<br />

Barbiero V 85<br />

Bardella E 99<br />

Bardelli C 35, 37, 140<br />

Barden N 62<br />

Barillari J 108<br />

Barletta MT 138<br />

Barnes A 78<br />

Barnes P 32<br />

Barnett A 100<br />

Baroc MF 91<br />

Barocelli E 118, 134, 145<br />

Baroffio M 133<br />

Barone D 137<br />

Barone E 127<br />

Barraco A 141<br />

Barrese V 81<br />

Barrile V 94<br />

Bartella C 102<br />

Bartesaghi S<br />

Bartoli F 104, 109, 110<br />

Bartolini A 92, 116, 43<br />

Bassi A 95, 107<br />

Basta F 102<br />

Bastia E 80, 114<br />

Bastianelli A 58, 80<br />

Bastoni S 111<br />

Battaglia G 65, 87, 88, 7, 116,<br />

126,<br />

Battisti E 128<br />

Batuwangala M 114<br />

Bazzani C 53, 117, 126<br />

Bazzu G 36, 64, 90, 94<br />

Beani L 122<br />

Bechi P 83<br />

Be<strong>di</strong>ni A 113<br />

Belfiore D 36<br />

Bellanti F 91<br />

Bellantuono C 28, 39, 141<br />

Bellik L 48, 54, 59<br />

Bellini G 35<br />

Bellini M 109<br />

Bellis A 100, 110<br />

Bellosta S 121, 43<br />

Belluardo N 65<br />

Bellucci A 140<br />

Beltramo M 76<br />

Benatti C 62, 85<br />

Bencini A 102<br />

Benelli A 79, 101<br />

Benemei S 129<br />

Benincasa M 79<br />

Benini A 37, 61, 112<br />

Benoni G 107<br />

Bergersen L<br />

Bernar<strong>di</strong>ni N 98<br />

Bernar<strong>di</strong>ni R 43, 81<br />

Bernini F 121<br />

Berrino L 37, 38, 53, 84, 115,<br />

120<br />

Berta GN 59, 104<br />

Berta L 104<br />

Bertacca L 116<br />

Bertarione Rava Rossa L 137<br />

Bertelli L 142<br />

Berti F 48, 83, 121<br />

Berti M 83<br />

Bertini R 138<br />

Berto E 146<br />

Bertocchi I 88<br />

Bertolini A 30, 31, 53, 105, 125,<br />

130<br />

Bertoni S 79, 118, 134, 145<br />

Bertorelli R 50<br />

Bertossi F<br />

Betti N 80<br />

Bettiol E<br />

Bettoni I 129<br />

Bezzi P 44<br />

Biagi GL 108<br />

Biagi M 136<br />

152


Biagioli T 140<br />

Biagioni F 87, 97, 126<br />

Biamonte F 140<br />

Bianchi A 129, 130<br />

Bianchi F 98<br />

Bianchi M 83<br />

Bianco F<br />

Bianco G 83, 100, 108, 119, 135<br />

Biasin A<br />

Bifulco M 76, 108<br />

Biggio F 61, 85, 131<br />

Biggio G 26, 27, 30, 36, 38, 53,<br />

56, 61, 66, 76, 77, 82, 85, 88,<br />

95, 131, 144<br />

Billington RA 115<br />

Bin A 107, 134<br />

Binaschi A 146<br />

Bion<strong>di</strong> DM 145<br />

Bion<strong>di</strong> S 102, 114<br />

Bisio A 144<br />

Bisogno A 129, 130<br />

Bitto A 54, 58, 101, 117, 120,<br />

126, 127, 135, 136<br />

Bizzarri C 138<br />

Bizzarro V 79<br />

Blan<strong>di</strong>na P 114, 125<br />

Blan<strong>di</strong>zzi C 42, 59, 60, 98, 106,<br />

109, 110, 134, 143<br />

Blasevich M 124<br />

Blom JMC 62, 85<br />

Bocci G 59, 81, 138<br />

Boccuti S 37<br />

Boldrini L 147<br />

Bolego C 57, 83, 101<br />

Bolla M<br />

Bolle P 109<br />

Bombar<strong>di</strong>eri S 110<br />

Bombelli R 50, 140, 145<br />

Bonamassa B 108<br />

Bonanno G 81, 82, 105<br />

Bonatesta RR 111<br />

Boncompagni E 117<br />

Bongers G 114<br />

Bonini SA 65,124<br />

Bonito MC 144<br />

Bono A 142<br />

Bono G 146<br />

Bonomo SM 83, 135<br />

Bonuccelli U<br />

Borea PA 28, 37, 61, 112, 133<br />

Borghi V 102<br />

Borner Perrone I 105, 142<br />

Borracci P 36<br />

Borrelli F 58<br />

Borroni E 102<br />

Borsini F 51, 86, 89<br />

Bortolato M 94<br />

Boschi F 84, 99, 142<br />

Boscia F 77, 126<br />

Bosisio E 145<br />

Bossi M 110<br />

Bothmann H 92<br />

Botta M 79, 136<br />

Botta P 36<br />

Bottai D 125, 127<br />

Bottelli A 121<br />

Botti F 60<br />

Botticelli A 117, 126<br />

Bottinelli R<br />

Bova S 119<br />

Bozac A 146<br />

Bozzo L 112<br />

Braconi S 93, 132<br />

Braghiroli D 121<br />

Braida D 61, 97<br />

Bramanti P 38, 66, 79, 133, 145<br />

Brambilla M 54, 119<br />

Brancaleone V 54, 83, 133<br />

Brassart L 111<br />

Brausi M 142<br />

Breckenridge A 46<br />

Breghi L 54<br />

Brera F 89<br />

Breschi MC 134<br />

Bresciani E 136<br />

Bretoni L<br />

Brini AT 111<br />

Brivio I 119<br />

Brocadello F 107<br />

Broccardo M 98, 99, 135<br />

Broccoli M 134<br />

Brockmann MD 131<br />

Brodows D<br />

Brodows RG 99, 100<br />

Brogioni S<br />

Brown J 141<br />

Brucato L 58<br />

Brun P 134<br />

Brunelleschi S 35, 37, 140<br />

Brunelli S<br />

Brunello N 33, 62, 85<br />

Bruni E 103, 139<br />

Bruni R 145<br />

Bruno V 65, 87, 88, 96, 97, 126<br />

Bruno A 138<br />

Brusa R 76<br />

Bruscoli S 58, 80, 103, 137<br />

Brusoni B 54<br />

Buanne P 138<br />

Buccellati C 101, 119<br />

Bucci M 54, 83, 133<br />

Buccianti P 134<br />

Buckingham J 33<br />

Bucolo C 137<br />

Buiatti E<br />

Buitelaar JK<br />

Bulgarelli I 136<br />

Bunnett NW 131<br />

Buonocore G 127<br />

Bur<strong>di</strong> R 127<br />

Busceti C 97, 126<br />

Busconi P 144<br />

Bushe C 141<br />

Buti D 105<br />

Butt A 131<br />

Buzzi A 117, 146<br />

Bymaster B 56<br />

Caboi F 110, 111<br />

Cabras A 65, 110<br />

Cabras S 85<br />

Caccia C 93<br />

Caccia S<br />

Cacciapaglia F 96<br />

Caciagli F 28<br />

Caderni G 137<br />

Caffino L 118<br />

Caggia F 62, 85<br />

Cagliati L 144<br />

Cagnar<strong>di</strong> P 130<br />

Cajozzo M 138<br />

Calabrese F 85<br />

Calabrese V 128<br />

Calabresi L 54, 84, 121<br />

Calafiore M 116<br />

Calapai G 95, 97, 99, 107, 130,<br />

144<br />

Calascibetta A 138<br />

Calcagno E<br />

Calciano S 81, 84<br />

Calderoni S 106<br />

Calia G 64, 79, 90, 94<br />

Calignano A 42, 50, 128, 136<br />

Calixto J 99<br />

Calligaro G 134<br />

Calò G 49, 122, 132<br />

Calò L<br />

Caltagirone C 116<br />

Calza A 88<br />

Camarda V 78, 114<br />

Camera M 54, 119<br />

Camerino GM 47, 127<br />

Cammarano M 124<br />

Campana G 123, 130<br />

Campese A 50<br />

Campesi I 57, 100<br />

Campi B 131, 132<br />

Campioli E 121, 136<br />

Campolongo P 94<br />

Canapaio R 104, 111<br />

Canavesi M 121<br />

Canciani L 98<br />

Candeletti S 92, 97<br />

Can<strong>di</strong>ani S 79<br />

Caldura SM 133<br />

Candussio L 104<br />

Canetta A<br />

Caniglia S 57, 64, 90<br />

Canistro D 108<br />

Cannarile L 137<br />

Cannella N 97, 132<br />

Cannizzaro C 94, 95<br />

Cannizzaro E 94<br />

Cannizzaro G 94, 95, 88, 131<br />

Canonico PL 41, 60, 104, 115,<br />

123, 125<br />

Cantalamessa F 108<br />

Cantara S 91<br />

Cantarella G 81<br />

Cantelli Forti G 39, 58, 88, 147<br />

Cantoni O 64, 117<br />

Cantore M 102<br />

Canu S 57, 100<br />

Canzoniero LMT<br />

Corsi V 90<br />

Capaccioli S 80<br />

Caparrotta L 81, 83<br />

Capasso A 76, 88, 93, 107, 123,<br />

124, 129, 130<br />

Capasso F 58<br />

Papasso R 58<br />

Capecchi PL 28<br />

Capellino S 49<br />

Capone J 129<br />

Capone ML 47, 54, 84<br />

Capone G 85<br />

Capozzo M 147<br />

Cappa M 124<br />

Cappetta D 47<br />

Cappuccio I 77<br />

Capra V 133<br />

Caprioli D 96, 97<br />

Capuano A 47, 107, 120, 143<br />

Capurro V 61, 97<br />

Caputi AP 29, 38, 40, 53, 54, 58,<br />

66, 95, 97, 99, 101, 107, 111,<br />

120, 127, 135, 136, 138, 143,<br />

144<br />

Caraci F 91, 116<br />

Canaglia M 128<br />

153


Caramelli A 89<br />

Caramori G 133<br />

Carangi R 119<br />

Carbonara G 115<br />

Carbonaro V 91<br />

Carbone F 147<br />

Carcano E 50, 140, 145<br />

Caria S 61, 85, 131<br />

Caricasole A 46, 78, 92, 113, 126<br />

Carina V 104<br />

Carissimi R 124<br />

Carletti F 88<br />

Carletti M 108<br />

Carlin A 53<br />

Carloni S 65,127<br />

Carlucci F 117<br />

Carmassi C 142<br />

Carmignani M 60, 109<br />

Carminati P 89<br />

Carnini C 102<br />

Carnuccio R 43, 111, 116<br />

Carone C 30<br />

Caronno A 110, 139<br />

Carra’ G 78<br />

Carratù MR 36<br />

Carretta MT 96<br />

Carru C 57<br />

Carruba M 67<br />

Carta AR 89<br />

Carta D 94<br />

Carta M 36, 76, 77, 131<br />

Carta P 142, 143<br />

Carta S 57<br />

Carullo P 119<br />

Carusio N 37<br />

Caruso A 78, 86, 96, 112, 113<br />

Caruso M 61<br />

Casadonte R 89<br />

Casale F 62, 128, 144<br />

Casamenti F 46, 90, 91, 140<br />

Cascino A 120<br />

Cascio E 146<br />

Casini P 128<br />

Casini L 105<br />

Casnici C 140<br />

Casolari P 123, 126<br />

Cassano T 31, 89, 91, 118<br />

Castagliuolo I 134<br />

Castagnola P 79<br />

Castaldo P 31, 35, 115<br />

Castellana CR 130, 135<br />

Castelli MP 94<br />

Castelli P 139<br />

Casti P 76, 123<br />

Castiglioni L 139<br />

Castiglioni C<br />

Castrignanò S 57, 123<br />

Casu G 76, 123<br />

Casula MG 94<br />

Catalani A 123, 126<br />

Catalano A 114<br />

Catania MA 53, 107, 111, 116,<br />

117, 118, 123, 125, 128, 144,<br />

145<br />

Catania A 53, 107, 111, 116,<br />

117, 118, 123, 125, 128, 144,<br />

145<br />

Catena M 142<br />

Cathalà A<br />

Cattabeni F 65<br />

Cattaldo S 106<br />

Cattaneo A 85<br />

Cattaneo E<br />

Cattaneo MG 38, 57<br />

Cattarini G 120<br />

Cavaliere F 65<br />

Cavallesco G<br />

Cavalli M 119<br />

Cavalli R 106<br />

Cavallo F 59, 88<br />

Cavallo P 76<br />

Cavani F 79<br />

Cavo M 147<br />

Ceccarelli L 110<br />

Cecchi E 107<br />

Celano M 79, 136<br />

Celentano M 96, 97, 125<br />

Cella S 40, 135<br />

Centenaro C 119<br />

Ceolotto G 119<br />

Cerbai E 45, 47, 59<br />

Cereda E 139<br />

Cerioni L 117<br />

Cerretani D 128, 138<br />

Cerulli A 65<br />

Ceruti S 35<br />

Cervetto C 62, 79, 112<br />

Cervio E 99, 135<br />

Cervo L<br />

Cesare P 60, 94, 109, 116, 120,<br />

128<br />

Ceserani I 144<br />

Changeux JP 30, 117<br />

Chazot P 125<br />

Cherchi A 147<br />

Chiappetta G 138<br />

Chiaravalli A 98<br />

Chiarella P 148<br />

Chiarugi A 114, 127<br />

Chiarugi M 134<br />

Chiesa G 48<br />

Chiesara E 40, 48, 108<br />

Chikhladze M 117<br />

Chillotti C 106, 146, 147<br />

Chimirri A 87<br />

Chinellato A 40, 48<br />

Chini B 57<br />

Chirafisi J 128<br />

Chiroli S 40<br />

Christian H<br />

Ciampi O<br />

Cianchi F 80<br />

Ciapparelli A 142<br />

Cicala C 134<br />

Ciccarelli R 86<br />

Ciccocioppo R 41, 49, 93, 97,<br />

122, 123, 132<br />

Ciceroni C 77<br />

Cifani C 122<br />

Cifelli G<br />

Cignarella A 57, 83<br />

Cigognini D 125<br />

Cilio MR 35<br />

Cillo U 117<br />

Cimino F 109, 128<br />

Cimino M 126<br />

Cimpanelli MG 139<br />

Cinci L 102<br />

Cinotti S 120<br />

Cinque C 114, 123, 126<br />

Ciofi L 59, 142<br />

Cioppa T 138<br />

Cipollaro M 120<br />

Cipollini F 107<br />

Cipollone F 60<br />

Cippitelli A 93, 123, 132<br />

Cippone V 47, 115, 127<br />

Cipriani S 61<br />

Cirino G 32, 54, 55, 64, 83, 101,<br />

133<br />

Citraro R 86, 87<br />

Citro S 133<br />

Ciuffi M 102<br />

Clementi E 64<br />

Coccia C 105, 130<br />

Cocco GA 76<br />

Cocucci M 145<br />

Coinu R 57, 140<br />

Colaianna M 57, 123<br />

Colangelo D 104<br />

Colavito D 91<br />

Coletta I 102<br />

Coletta T 84<br />

Colica C 128, 146<br />

Colleoni M 61, 129<br />

Collier D 131<br />

Collino M 48, 58<br />

Collura D 88<br />

Colnago D 54<br />

Colombo A<br />

Colombo C 139<br />

Colombo G 53<br />

Colombo ML 140<br />

Colucci MA 42, 93, 122, 144<br />

Colucci R 98, 109, 110, 134<br />

Coluccia A 36<br />

Comazzi M 124<br />

Comelli F 61, 129<br />

Comhair S 132<br />

Comi G 50<br />

Compostella F 140<br />

Conal<strong>di</strong> G 121<br />

Concas A 35, 62, 88<br />

Concas D 111<br />

Con<strong>di</strong>no AM 113, 117<br />

Condorelli F 104, 115<br />

Confalonieri P 127<br />

Congiu D 146, 147<br />

Consoli D 36<br />

Consoli G 142<br />

Consoli GML 80<br />

Constanti A 87<br />

Conte AM 147<br />

Conte Camerino D 36, 45, 47,<br />

114, 115<br />

Conti A 140<br />

Conti S 50<br />

Conti V 37<br />

Conti L<br />

Contis M 111<br />

Conzen S<br />

Copani A 41, 91, 116, 123<br />

Coppi A 103, 139<br />

Coppi G 139<br />

Coppi E 113<br />

Corasaniti T 43, 65, 145, 146<br />

Corbi GM 37<br />

Corbo F 115<br />

Corcione E 31, 115<br />

Corda G 76<br />

Corinaldesi R 99<br />

Cornaglia G<br />

Cornelli L 48<br />

Corona C<br />

Corrao G 40<br />

Corsaro A 79<br />

Corsello S 107<br />

Corsi L 57, 58, 102<br />

Corsi M 124<br />

154


Corsini A 83, 121<br />

Corsini E 137<br />

Corsini G 113, 89<br />

Corsini D 62, 85<br />

Corso G 138<br />

Corso M 78<br />

Corti F 80<br />

Corti C 65<br />

Coruzzi G 98<br />

Cosco D 136<br />

Cosentino M 49, 50, 139, 140,<br />

145, 146<br />

Cossu G 30<br />

Costa B 61, 129<br />

Costa F 110<br />

Costa N 84, 87, 93<br />

Costantino L 31, 125<br />

Costantino M 128<br />

Costantino S 77<br />

Cotrufo M 120<br />

Cottrell G 131<br />

Covarello D<br />

Cozza G 81<br />

Cozzi A 115<br />

Cozzoli A 127<br />

Cozzolino A 128<br />

Crea F 147<br />

Crema F 98<br />

Crepal<strong>di</strong> T 136<br />

Crescimanno M 138<br />

Crespi C 139<br />

Cricelli C 39, 40, 52, 63<br />

Crimi E 133<br />

Criollo A 116<br />

Crisafulli C 66, 103<br />

Cristalli G<br />

Cristani MT 128, 145<br />

Cristante T<br />

Perrotta C<br />

Cristino L 76, 100<br />

Cristita P 132<br />

Crobu D 110<br />

Croci T 134<br />

Crotta K 140<br />

Crouch N<br />

Cuboni S<br />

Cuccurullo C<br />

Cuccurullo F<br />

Cuda G 87<br />

Cuomo O 126<br />

Cuomo V 30, 31, 34, 57, 89, 90,<br />

91, 94, 118, 123, 125<br />

Cupani C<br />

Curatolo P 141<br />

Curcuruto R 144<br />

Curinga C 87<br />

Currò D 97<br />

Curti D 60<br />

Cusinato F 78, 117<br />

Cutroneo P 144<br />

Cutroneo PM 143<br />

Cuzzocrea S 38, 50, 55, 66, 100,<br />

103, 120, 133, 137, 138, 145<br />

Cuzzolaro M 95<br />

Cuzzolin L 107<br />

Cvorovic J 104<br />

D’Addario C 97<br />

Da Settimo F 134<br />

Dacasto M 108<br />

D'Acquisto F 102<br />

D'Acunto CW 59<br />

Daffara F 58<br />

D'Agostino B 132, 133, 32, 49<br />

D'Agostino G 42, 50, 113, 117,<br />

128, 129<br />

D'Agostino S 88<br />

Daina Economidou 132<br />

Dal Ben D<br />

Dal Cero E 145<br />

Dal Piaz V 93<br />

D'Alessandro N 37, 104, 110<br />

D'Alfonso R 104<br />

D'Alimonte I<br />

Dalle Carbonare M 91<br />

Dall'Olio R 123, 132<br />

Damiano V 37<br />

D'Amico A 98, 137<br />

D'Amico M 81, 84, 136<br />

D’Amico Monia 81, 84, 136<br />

D'Amico D 96<br />

Danesi R 50, 59, 81, 103, 138,<br />

142, 146,147<br />

D'Anna R 58, 135<br />

D'Antona G<br />

Daperno M 111<br />

D'Aquila PS 94<br />

Darnaudery M<br />

D'Arrigo A 91<br />

D'Arrigo C 124<br />

D'Arrigo M 145<br />

Dattolo MG 136<br />

D'Auro M 86<br />

Dahl ML 146<br />

Davoli A 105, 142<br />

Dazzan P 131<br />

Dazzi L 56, 82, 85<br />

De Amici E 133<br />

De Angelis S 133<br />

De Angelis A 47<br />

De Bellis M 115<br />

De Bellis A 100<br />

De Bene<strong>di</strong>ctis L 119<br />

De Esch Iwan IP 98<br />

De Fazio P 126<br />

De Fazio S 106<br />

De Filippis D 43, 137, 90, 91, 98<br />

De Francia S 58<br />

De Gennaro Colonna V 83, 121<br />

De Giorgi A 123<br />

De Giorgio R 99, 135<br />

De Girolamo L 111<br />

De Gruttola L 83, 133<br />

De Iu<strong>di</strong>cibus S 110<br />

De Libero G 140<br />

De Lisa R<br />

De Luca A 47, 115, 127<br />

De Luca MA 86<br />

De Luca N 110<br />

De Luca P 120<br />

De Luca V 98<br />

De Man J 98<br />

De Marco T 97<br />

De Martin S 142<br />

De Martino F 58<br />

De Mattei M 112<br />

De Matteis F 109<br />

De Metrio M 54<br />

De Nardo M 132, 133<br />

De Novellis V 43, 47, 92<br />

De Petrocellis L 76, 129<br />

De Ponti F 42, 134, 135<br />

De Rosa G 111<br />

De Salvia MA 94<br />

De Santi S 102<br />

De Sarro A 35, 99, 138<br />

De Sarro G 40, 80, 86, 87, 105,<br />

106, 126, 132, 142<br />

De Siena G 129<br />

De Stefano D 43, 47, 111<br />

De Vanna M 147<br />

De Vita T 78<br />

De Winter B 98<br />

Deambrosis P 48<br />

Debutto P 78<br />

Decorti G 104, 109, 110, 119<br />

Dedola S 36, 79, 94<br />

Dedoni S 65, 86, 126<br />

Deghenghi R 135<br />

Deidda F 148<br />

Del Basso Orsini P 84<br />

Del Bufalo D 138<br />

Del Duca C<br />

Del Giu<strong>di</strong>ce E 91<br />

Del Soldato P 48<br />

Del Tacca M 103, 106, 109, 110,<br />

134, 138, 142, 143, 144, 416,<br />

147, 40, 42, 59, 81, 98<br />

Del Vecchio I 128, 137<br />

Del Zompo M 29, 106, 142, 143,<br />

146, 147<br />

Delfino D 140<br />

D'Elia P 109<br />

Della Bianca A 133<br />

Dell'Agli M 145<br />

Dell'Agnello G 56, 141<br />

Dell'Osso L 142<br />

Demma I 135<br />

D'Emmanuele Di Villa Bianca R<br />

101, 119, 120<br />

Demontis MP 51, 108<br />

Dempster D 39, 131<br />

Desaphy JF 36, 114, 115<br />

Desideri M 138<br />

Desole MS 47, 79<br />

Dessì C 125<br />

Devono G<br />

Di Benedetto M 97<br />

Di Carlo F 58, 59, 104, 108<br />

Di Carlo S 96<br />

Di Cesare Mannelli L 116<br />

Di Chiara G 51, 86, 96, 130<br />

Di Febbo C 54<br />

Di Filippo C 84, 136<br />

Di Forti M 131<br />

Di Francesco L 47, 102, 84<br />

Di Giannuario A 122, 144, 42, 93<br />

Di Giulio AM 79, 125, 127<br />

Di Giuseppe D 108, 120, 121<br />

Di Gregorio P 84<br />

Di Iorio P<br />

Di Lorenzo A 54, 83, 133<br />

Di Luca M 41, 65<br />

Di Marzo V 34, 43, 47, 76, 100,<br />

129<br />

Di Matteo A 102<br />

Di Paola R 66<br />

Di Paolo A 59, 138, 142, 146,<br />

147<br />

Di Pardo A 113, 119<br />

Di Pirro M 107<br />

Di Renzo G 110, 126<br />

Di Simplicio P 108, 120, 121<br />

Di Stefano A 108<br />

Di Stefano R 110<br />

Di Stefano V 54, 120, 127<br />

Di Toro R 113, 58<br />

Di Vita G 124<br />

Diana Estello M<br />

155


Diana M 131, 36, 41, 43, 51, 95,<br />

96<br />

Diani E 48<br />

Dianzani C 48, 58<br />

Diaspro A 90<br />

Di Giannuario A 42, 122, 144<br />

Diliberto I 95<br />

Dimida A 113<br />

Diodato E 92<br />

Di Palma A 114, 36<br />

Di Pasquale P 125<br />

Distasi C 125<br />

Dolora P 137<br />

Domenica MR 82, 118, 126<br />

Donati E 102, 113<br />

Donati V<br />

Donato G 126<br />

Donato V 137, 58<br />

Donniacuo M 47, 120<br />

Donnini S 91, 101, 118, 119<br />

Dore B 94<br />

Dore R 88, 36<br />

Dorent R 121<br />

Dorigo P 83<br />

Dossena M 84, 142<br />

Dossi G 99<br />

Dorent R 121<br />

Dorigo P 83<br />

Dossena M 84, 142<br />

Dossi G 99<br />

Douville K 54<br />

Downey P 76<br />

Drago F 125, 33, 36, 59, 117<br />

Dragoni S 104, 109<br />

Drigo I 110<br />

Ducci E 106<br />

Dunlop J 92<br />

Duran S 99, 100<br />

Duranti A 132<br />

Ean<strong>di</strong> M 104, 106, 111<br />

Eberini I 54<br />

Eboli ML 54<br />

Economidou D 93, 97, 132<br />

Edwards G 97<br />

El Khoury A 85, 118<br />

Emanueli C<br />

Enea D 95<br />

Enrico P 126, 131, 133, 136, 137<br />

Epis R 57, 64, 65, 66, 79, 90,<br />

131<br />

Ercolano E 115<br />

Ercolino SF 79, 102<br />

Ermito S 128<br />

Ernst E 58<br />

Errico S 127<br />

Erriquez J 125<br />

Erzurum S 132<br />

Esposito E 38, 50, 66, 83<br />

Esposito Giovanni 43, 64, 90,<br />

91, 98<br />

Esposito Giuseppe<br />

Etzi R<br />

Eusebi F 88, 114<br />

Eva C 57, 88, 95<br />

Evandri MG 109<br />

Evangelista V 47<br />

Evoli A 45<br />

Evrard A 117<br />

Eyeson J 131<br />

Francini-Pesenti F 107<br />

Fabbri L 32<br />

Fabene PF 146<br />

Fabi F 84<br />

Fabrizi F 142<br />

Facchi A<br />

Facchinetti F 91<br />

Fadda P 30, 130<br />

Failli P 102<br />

Falcone A 59, 80, 81, 138<br />

Falcone D 80<br />

Fallarini S 140<br />

Falzarano S 113<br />

Fanelli R 60<br />

Faniglione M 133<br />

Fanos V 142<br />

Fantin Marianna 61, 78<br />

Fantin Martina<br />

Fanton G 78<br />

Fantozzi R 48, 51, 58<br />

Faraco G 127<br />

Farina C 43<br />

Fascì D 137<br />

Fattore L 30, 31, 130<br />

Faure P 117<br />

Fava G 107, 111<br />

Favari E 121<br />

Fazia ML<br />

Fazio VM 148<br />

Fedele E 82<br />

Fedeli A 93<br />

Femia AP 137<br />

Fenu S 89, 96<br />

Feo C 61<br />

Feo S 138<br />

Ferioli E 121<br />

Ferraguti F 87<br />

Ferrante L 107, 144<br />

Ferranti F 77<br />

Ferranti S 144<br />

Ferrara A<br />

Ferrara N 37<br />

Ferrari A 105, 130<br />

Ferrari D 35<br />

Ferrari M 50, 139, 140, 146<br />

Ferrarini E 113<br />

Ferrario P 83<br />

Ferrari-Toninelli G 65<br />

Ferraro L 31, 65<br />

Ferraro MT 138<br />

Ferraro G 88<br />

Ferreira J 99<br />

Ferreri Ibbadu G 86, 87, 106<br />

Ferrero V 37<br />

Ferretti C 62<br />

Ferretti M 79<br />

Ferri N 121<br />

Ferrieri A 136<br />

Ferrigno A 117<br />

Ferroni S 112<br />

Festa A 99, 100<br />

Festa M 59, 79, 102, 138<br />

Festa R<br />

Fiaschi AI 128, 138<br />

Filaferro M 30, 122<br />

Filigheddu N 136<br />

Filippelli A 29, 37, 43, 47, 107,<br />

120, 128, 144<br />

Filippetti R 122<br />

Filippi S 54<br />

Filippi U 51<br />

Fimognari C 58<br />

Finetti F 101,113<br />

Finicelli M 120<br />

Finocchiaro G 44<br />

Finotti P 37<br />

Fioravanti A 81, 138<br />

Fiorentini A 90, 91, 140<br />

Fioretti MC 51, 55<br />

Fiorito S 120<br />

Fiorucci S 54<br />

Firenzuoli F 107<br />

Fischetti C 78<br />

Fiumara T 54, 101, 120, 136<br />

Flammini L 118<br />

Flan<strong>di</strong>na C 138<br />

Floreani M 61<br />

Florent H<br />

Florio T 79, 90<br />

Flower RJ 102<br />

Foffa I<br />

Fogli E 61, 112, 133<br />

Foglia C 76<br />

Folco G 32, 101, 102, 119<br />

Follesa P 61, 85, 131<br />

Fontaine B 45<br />

Fontanini G 50, 147<br />

Forlani A 50<br />

Formentini L 127<br />

Formisano C 102<br />

Fornai F 45, 97, 126<br />

Fornai M 98, 110, 134<br />

Forni F 31, 125<br />

Forni G 59<br />

Forte A 120<br />

Fortuna A 123<br />

Fossati Giacomo 104, 127<br />

Fossati Gianluca<br />

Fossati S 114, 127<br />

Fournier J 65<br />

Fracasso C<br />

Fracchiolla G 115<br />

Frairia R 104<br />

Franceschelli S 79<br />

Franceschetti S 117<br />

Franceschetti L 113<br />

Franceschi M<br />

Franceschini G 54, 84<br />

Franchi Gian Gabriele 107, 144,<br />

145, 43<br />

Franchi Gianfranco<br />

Franchi S 129, 42, 43, 96<br />

Franchini C 114, 115<br />

Franconi F 100, 123, 140, 39, 57<br />

Frasca A 86<br />

Frasca G 91<br />

Frasson M 37<br />

Frassoni C 117<br />

Fratta W 130, 30, 31, 33, 34,<br />

Fratto V 145, 146<br />

Fratto D 80<br />

Frau L 89<br />

Frau R 94<br />

Fredduzzi S 50<br />

Fre<strong>di</strong>ani S 141<br />

Freeman B 131<br />

Freitas I 117<br />

Fresta M 136<br />

Fresu LG 35<br />

Frigeri A 127<br />

Frigeri C 122<br />

Frigo G 40,98<br />

Frisina N 135, 98<br />

Frol<strong>di</strong> G 81, 83<br />

Frosali S 108, 120, 121<br />

Frosini M 104<br />

Fruttarolo F<br />

Fucile S 88<br />

Fumagalli F 86<br />

Fumagalli M<br />

156


Fumero S 137<br />

Furlanut M 40<br />

Fusco F 142<br />

Fusi F 104<br />

Fuxe K 30, 65<br />

Gabano E 103, 104<br />

Gabbianelli R 108<br />

Gaetani S 31, 125<br />

Gagliani MC 90<br />

Gagliano A 124<br />

Gagliano C 124<br />

Gagliano Maria G<br />

Gagliano M 94, 135<br />

Gagliar<strong>di</strong> S 83<br />

Gaion RM 83, 107, 134<br />

Gala R 126<br />

Galantucci M 117, 126<br />

Galassi G 142<br />

Galderisi U 120<br />

Galdo M 143<br />

Galeotti N 92<br />

Galeotti T 128<br />

Galletta G 123<br />

Galimberti D 135<br />

Gallelli L 80, 105, 106, 132, 142<br />

Gallesi D 105, 139<br />

Galli C<br />

Gallicchio M 48, 58<br />

Gallo M 144<br />

Gallo U 107<br />

Galluzzo M 126<br />

Galvez B<br />

Gandolfi O 123, 132<br />

Garattini S 144<br />

Garau L 86, 126<br />

Gardoni F 65<br />

Gareri P 106<br />

Garibol<strong>di</strong> MB 61, 103<br />

Garrone B 102<br />

Garuana A 130<br />

Garzon G 82<br />

Gasco MR 106, 111<br />

Gasperi V<br />

Gass P 56<br />

Gatta L 92, 129<br />

Gatti M 79<br />

Gatti R 131, 132<br />

Gavioli E 122<br />

Gaviraghi G 46, 92<br />

Gazzerro P 108<br />

Gazzieri D 99, 131<br />

Gebbia N 50, 138<br />

Gelosa P 43, 126<br />

Gelpi G 119<br />

Geminiani E 57, 58, 102<br />

Genazzani AA 62, 104, 115, 125<br />

Genedani S 30<br />

Gennarelli M 85<br />

Genovese R 111<br />

Genovese T 66<br />

Genuini GF 120<br />

Gentile MT 113, 119<br />

Gentile M 111<br />

Gentilella A<br />

Gentilella Raffaella 99, 100, 142<br />

Gentilella Robert<br />

George Alfred L Jr 47<br />

Geppetti P 32, 47, 83, 99, 101,<br />

120, 129, 131, 132<br />

Gerace E<br />

Geraci C 80<br />

Germini G 59<br />

Germanò E 124<br />

Geroni C 61<br />

Gerra G 96<br />

Gertow K 54<br />

Gessa GL 94<br />

Gessi S 37, 61, 112, 133<br />

Ghè C 100, 135, 136<br />

Ghelar<strong>di</strong>ni C 43, 92, 116<br />

Grezzi A<br />

Ghisu N 98, 109, 110, 134<br />

Ghizzar<strong>di</strong> P 134<br />

Giacca M 127<br />

Giaccone G 138, 147<br />

Giachetti A 91, 119<br />

Giachetti D 136<br />

Giaconia L 100<br />

Giagnoni G 61, 129<br />

Giambelli R 85, 118<br />

Giambene B 142<br />

Gianazza E 54<br />

Gianella A 43<br />

Gianfriddo M 61, 92<br />

Gianneli M<br />

Giannini E 50, 92<br />

Giannini L 132<br />

Giannoni P 125<br />

Giannuzzi V 115, 127<br />

Giaquinta G 57, 64, 90<br />

Giar<strong>di</strong>na S 60<br />

Gironi C 98<br />

Gigante B 110<br />

Gillies G<br />

Ginestra G 145<br />

Giordano C 43, 129<br />

Giorgi A 123, 145<br />

Giorgi Filippo<br />

Giorgi Franco 113<br />

Giorgi G 144, 145<br />

Giorgi M 105<br />

Giorgini S 138<br />

Giovannetti A 116<br />

Giovannetti E 103, 147<br />

Giovannini MG<br />

Giovannoni MP 93<br />

Giovinazzo C 144<br />

Giral<strong>di</strong> T 147<br />

Giral<strong>di</strong> P<br />

Giron MC 100, 107, 134<br />

Gironi A 100<br />

Gitto R 87<br />

Giuberti G 128<br />

Giuffrida A 89<br />

Giuffrida ML 116<br />

Giuliani D 53, 54, 98, 117, 126<br />

Giunta M 135<br />

Giuntini S<br />

Giussani L 142<br />

Giusti P 40, 48, 78, 86<br />

Giustini SE 106, 144<br />

Giustino A 36<br />

Gliozzi M 43<br />

Gloaguen I 138<br />

Gnemmi I 104<br />

Gobbi G 118<br />

Gobbi P 115<br />

Goetz I 141<br />

Goffredo D<br />

Gola M 96<br />

Goldberg SR 31, 125<br />

Golia F 142<br />

Golino P 38<br />

Gomaraschi M 54, 84<br />

Gontero P 142<br />

Gori E 97<br />

Gori G 109, 110<br />

Gorini A 89<br />

Gorini G 61, 85, 131<br />

Gorio A 44, 79, 125, 127<br />

Gosmar M 109<br />

Govoni P 137<br />

Govoni S 90, 137<br />

Granata A 121<br />

Grande V 79<br />

Gran<strong>di</strong> D 97<br />

Granito A 99<br />

Granucci F 129<br />

Grassi MC 33, 95<br />

Graziani A 136<br />

Gridelli B 110<br />

Grieco P 53<br />

Grilli M 36, 82<br />

Grimal<strong>di</strong> C 76<br />

Grion AM 107<br />

Grohmann U 55<br />

Grossi C 90, 91<br />

Grossi S 108<br />

Grosso S 110, 139<br />

Gruber S 86<br />

Guaita A 135<br />

Guaita E 98<br />

Gualco A 84<br />

Guaral<strong>di</strong> G 139<br />

Guarini S 37, 53, 54, 101, 117,<br />

126<br />

Guarino I 123<br />

Guarnieri S 62, 79, 112<br />

Guastaferro M<br />

Guasti L 139, 140<br />

Guazzi M 83<br />

Guerriere L 102<br />

Guerrini Remo<br />

Guerrini Renato 78, 93, 97, 98,<br />

114, 122, 132, 135<br />

Guerrini U 126<br />

Guglielmi MD 54<br />

Guglielmotti 102<br />

Guida F 92, 129<br />

Guidali C 31, 61<br />

Guidarelli A<br />

Guidobono F 98<br />

Guidolin D 30, 79<br />

Gulotta G 138<br />

Gunella G 35, 140<br />

Guzzetta M 114<br />

Guzzetti S<br />

Har<strong>di</strong>man G 123<br />

Haro J 141<br />

Harrison S 83, 101, 131<br />

Haycox A 40<br />

Hebbes C 78<br />

Heilig M 132<br />

Heine R 99<br />

Ho L 124<br />

Hoogwerf B 100<br />

Hoozemans J<br />

Hrelia P 58, 88, 147<br />

Hwa J 54<br />

Iacobelli M<br />

Iacono A 50, 83, 100, 128<br />

Iacovelli L 86<br />

Iadarola P 142<br />

Iannone M 87<br />

Iannotti F 81<br />

Iannuccelli V 139<br />

Ibba F 96<br />

Ieri F 140<br />

Iezzi A<br />

157


Iezzi M 59<br />

Illiano M 144<br />

Imbimbo B 91<br />

Imbimbo C 101<br />

Impagnatiello F 90, 102, 114<br />

Imperatore F 120<br />

Impicciatore M 118, 134, 145<br />

Improta G 49, 98, 99, 135<br />

Incorvaia L 138<br />

Infante F 129, 130<br />

Inguglia L 104<br />

Innocenzi A<br />

Invernizzi R 51<br />

Ionta MT<br />

Iori R 108<br />

Ippolito C 98<br />

Isaia E 79<br />

Isola M 130<br />

Iu<strong>di</strong>ce A 146<br />

Iuvone T 43, 90, 91,98 ,137<br />

Jaconi M<br />

Jason S 76<br />

Jensen S 146<br />

John C<br />

Johns Don 99, 100<br />

Johns Don J<br />

Johns J<br />

Juri B 81<br />

Kachare D<br />

Kallupi M 97, 132<br />

Kawase M 109,<br />

Kelsey D 141<br />

Kerbel R 55<br />

Kim Dennis 99, 100<br />

Kim Don<br />

Kim J<br />

Klinge I<br />

Kloting I 122<br />

Klugmann S 54<br />

Koorbanally C<br />

Kostenis E 78<br />

Krankel N<br />

Kroemer G 116<br />

Kuka M 140<br />

Kunic J 47<br />

La Barbera D 131<br />

La Barbera M 94<br />

La Cascia C 131<br />

La Ferla F<br />

La Grutta V 88<br />

La Rana G 42, 50, 128, 129, 136<br />

Labbozzetta M 37, 104, 110<br />

Laghi Pasini F<br />

Laguar<strong>di</strong>a V 111<br />

Lamaida E 129, 130<br />

Lambert DG 114<br />

Lambertucci C<br />

Lampa E 128, 136<br />

Lampus S 106, 147<br />

Lanas A 29<br />

Landucci E 115, 116, 118<br />

Lange DJ 124<br />

Langer F 142<br />

Lanni C 90<br />

Lapi F 107, 143<br />

Lastella M 59, 142, 146, 147<br />

Latorre R 114<br />

Lattanzi R 42, 50, 92<br />

Lattuada D 140<br />

Laus M 103<br />

Lazzari P 104, 121, 125<br />

Lazzeri M 49<br />

Le Fur G 34<br />

Lecca Daniele 96<br />

Lecca Davide 126<br />

Leccese V 96<br />

Lecchini S 50, 98, 139, 140, 145,<br />

146<br />

Ledda F 48, 54, 59<br />

Leggio GM 36, 117<br />

Legnaro M 139, 140<br />

Lembo A 142<br />

Lembo G 113, 119<br />

Lemoli M 94<br />

Lempereur L 81<br />

Lencioni M 59<br />

Lentini G 114<br />

Lenzi M 58<br />

Leon A 91<br />

Leonar<strong>di</strong> P 53<br />

Leone L 84<br />

Leone RL 128<br />

Leoni F 127<br />

Leoni O 143<br />

Leopar<strong>di</strong> G<br />

Lepine A 141<br />

L'Episcopo F 64, 79<br />

Lesma E 79<br />

Leto G 138<br />

Leung E 37, 61, 112<br />

Leurs R 98, 114<br />

Lewis D 141<br />

Li D 132<br />

Liantonio A 47, 114, 115, 127<br />

Licheri GL 147<br />

Ligas F 106<br />

Liguori G 120<br />

Linari G 99, 135<br />

Lintas A 36<br />

Lioi MB 108<br />

Lionetti P 110<br />

Liotti A 105<br />

Lisi I 78<br />

Lisi L 123<br />

Lo VJ<br />

Locatelli V 98, 136<br />

Locchi F 123, 132<br />

Lodovici M 137<br />

Logobar<strong>di</strong> F<br />

Lograno MD 78<br />

Loizzo Alberto 123, 107<br />

Loizzo Annalivia 57, 107<br />

Loizzo S 57, 107, 123<br />

Lombar<strong>di</strong> G 140, 146<br />

Lombardo G 143<br />

Lombardo M 104<br />

Lonati C 53<br />

Longini M 127<br />

Longo A 88<br />

Longo N 101<br />

Lopetuso G 92<br />

Loraschi A 139<br />

Lorenzini P 84<br />

Loriga G 125<br />

Losi G 77, 82<br />

Loupakis F 138<br />

Lourdusamy A 123<br />

Lovaglio S<br />

Lowry JP 36<br />

Lu H 95<br />

Lu J 90<br />

Lubrano C 58, 135<br />

Lucacchini A<br />

Luccarini I 90, 91, 140<br />

Lucchelli A 137<br />

Lucchino I 125<br />

Luccini E 82<br />

Luciani S 78, 117<br />

Lucini V 110, 139<br />

Lucioni C 40<br />

Ludovico GM 142<br />

Luini A 140, 145<br />

Luisi R 81<br />

Lungarella G 101, 131<br />

Luongo L 43<br />

Lupieri T 77<br />

Luppino MR 111<br />

Lutz B 76, 118<br />

Luzi S 131<br />

Lytton J 126<br />

Mac Lennan S 61, 112<br />

Maccari S 56, 123, 126<br />

Maccarrone M 65, 80<br />

Macchi B 116, 142<br />

Macheda T 91, 118<br />

Maciocco E 30, 76, 77<br />

Maclennan S 37<br />

Madaschi L 125<br />

Madeddu P 64<br />

Maestro A 104, 119<br />

Maffei A 113, 119<br />

Maffei F 147<br />

Maggi A 103<br />

Maggi R 125<br />

Maggio R 45, 113<br />

Magi S 31, 115<br />

Magnaghi G 117<br />

Magnaghi V 129<br />

Magnani F 105<br />

Magnelli L 80<br />

Magnotti MC 77<br />

Magrassi R 90<br />

Magri E 146<br />

Mai A 104<br />

Maida S 145, 146<br />

Mainero V 137<br />

Maio RC 139<br />

Maione F 42, 93, 122, 144<br />

Maione S 42, 43, 47, 60, 92, 129<br />

Mairesse J 123, 126<br />

Maiuri MC 111, 116<br />

Maj PF 85<br />

Malinverno M 65<br />

Mallei A 85<br />

Malleo G 138<br />

Malorni W 57<br />

Malusà N 110<br />

Mameli-Engvall M 117<br />

Manca A 79, 90, 94<br />

Manca I 104, 125<br />

Mancar<strong>di</strong> L 82<br />

Manchia M 147<br />

Mancini F 102, 141<br />

Mancini G 76<br />

Mancini M 141<br />

Manconi F 146<br />

Manconi M 129<br />

Mancuso C 127, 128<br />

Mandalari G 145<br />

Manera C 80, 105<br />

Manfre<strong>di</strong> B 48, 83, 121<br />

Manfre<strong>di</strong> L 143<br />

Manfre<strong>di</strong> V 108<br />

Mangano G 102<br />

Mangieri D 127<br />

Mannaioni G 115, 118<br />

Mannaioni PF 80<br />

Mannucci C 95, 130<br />

Manservigi R 146<br />

158


Mantia G 94, 95<br />

Mantovani A 50, 109<br />

Marabese I 92<br />

Marabini L 108<br />

Maranghi F 109<br />

Marasciulo FL 48, 83<br />

Marcellino D 30<br />

Marcello E 65<br />

Marcello S 93<br />

Marchese G 123, 76<br />

Marchesi M 48<br />

Marchetti B 57, 64, 79, 90<br />

Marchetti C 58<br />

Marchetti R 95<br />

Marchi M 36, 82<br />

Marchi S 109, 110<br />

Marcoli M 62, 79, 112<br />

Marconi A 137<br />

Marconi P 146<br />

Marcuzzo S 60<br />

Marelli O 140, 148<br />

Marenzi G 54<br />

Marfella R<br />

Marfia G 125<br />

Margaritis A 108, 120, 121<br />

Margheriti F<br />

Marigliano NM 105, 106<br />

Marilotti L 39<br />

Marinelli A 96<br />

Marini H 58, 101, 135<br />

Marini P 76<br />

Marino Franca 49, 50, 139, 140,<br />

145, 146<br />

Marino Gennaro 113<br />

Marino Laura 84<br />

Marino Marina 110<br />

Marino Sara<br />

Marino Silvia 110, 118<br />

Marinos LM 104<br />

Marinovich M 44<br />

Mariottini C 114<br />

Marongiu C 65, 111<br />

Marotto MF<br />

Marra C 88<br />

Marra R 86, 87, 131<br />

Marras E 61<br />

Marras R 131<br />

Marrelli D 138<br />

Marrocco G 132, 133<br />

Marrosu F 30, 85, 94<br />

Marsicano G 118<br />

Marte A 82<br />

Martelletti P 57, 105<br />

Martelli A 106, 108, 109, 144<br />

Martelossi S 109, 110<br />

Marti M 43, 49<br />

Martignoni E 146<br />

Martinelli M 43<br />

Martinelli V 142<br />

Martini C 43<br />

Martino G 64, 90<br />

Martire A 82<br />

Martire M 81<br />

Martorana A<br />

Martucci D 97<br />

Marzani B 60<br />

Marzatico F 60<br />

Marzocca C 132<br />

Marzocco S 108, 120, 135<br />

Marzola A 146<br />

Marzola E 144<br />

Marzola G 78, 122, 93<br />

Masami K<br />

Masami T 81<br />

Mascagni P 127<br />

Maschi O 145<br />

Mascia MP 76<br />

Mascolo N 122, 144<br />

Maselli MA 135<br />

Maselli R 80<br />

Masi G 56<br />

Masini E 132, 142, 64, 80<br />

Maskos U 30, 117<br />

Masotti G 120<br />

Massa F 76<br />

Massi D 131<br />

Massa E 148<br />

Massa M 49, 51, 122, 132, 93, 97<br />

Massa P 80<br />

Massidda B 50<br />

Mastino A 116<br />

Mastrangelo S 109<br />

Mastrantoni E 77<br />

Mastrogiacomo M 79<br />

Mastroiacovo F<br />

Mastroianni R 80<br />

Mastrotto C 140<br />

Matarrese P 57<br />

Materazzi S 83, 101<br />

Mathé A 86, 118<br />

Matias I 76, 100<br />

Matrisciano F 86, 96<br />

Mattace Raso G 83, 100<br />

Caleo M 81<br />

Matteoli M 81<br />

Matteucci P 123, 126<br />

Matteucci C 116<br />

Mattioli F 106, 108<br />

Matuschak G<br />

Matzeu A 82<br />

Maullu C 65, 111, 148<br />

Maura G 60, 62, 79, 112, 137<br />

Maurici A 37, 104<br />

Mauro A 106<br />

Mazza R 65<br />

Mazzaglia G 39, 40<br />

Mazzola C 36, 125<br />

Mazzon E 38, 65, 66, 103, 133,<br />

137, 138, 145<br />

Mazzoni E 65<br />

Mazzuferi M 146<br />

Mcdonald J 78, 114<br />

Mcgaugh LJ 94<br />

Meda C 57<br />

Medalie J 125<br />

Medhurst A 125<br />

Meini A 78<br />

Mela F<br />

Melani A 28, 61<br />

Melchiorri D 44, 77, 78, 86, 96,<br />

113, 114<br />

Melchiorri P 42, 43, 50, 92<br />

Mele A 114<br />

Mele P 88, 95<br />

Meli R 38, 50, 83, 100, 103, 128,<br />

145<br />

Meli S 80<br />

Melillo G 55, 135, 138<br />

Melis GB 62<br />

Melis MR 101, 130<br />

Melis M 31<br />

Melis T 130<br />

Memo M 41, 65, 124<br />

Mencacci C 28, 66<br />

Menchini Fabris F 142<br />

Mendlewicz J 85<br />

Menegazzi M 145<br />

Meneghelli I 143<br />

Meneguz A 39, 59<br />

Mengozzi G 105<br />

Menna PA 37<br />

Mennini T 60<br />

Merciaro G 84<br />

Mereu GP 94<br />

Mereu M. 131<br />

Merighi S 37, 61, 112, 133<br />

Merlicco A 88<br />

Merlo S 80, 91, 123<br />

Messina S 127<br />

Mey V 103, 147<br />

Mezzetti A<br />

Micale V 36<br />

Miccichè F 91<br />

Miceli F 35<br />

Miceli BG 138<br />

Micheli L 107, 144, 145<br />

Michellson D<br />

Miele E 64<br />

Migheli R 64, 79, 94<br />

Migliar<strong>di</strong> G 124<br />

Miglietta D 119<br />

Miglio GL 146<br />

Migliozzi A 129<br />

Mihm M 99<br />

Milanese M 82<br />

Milano L 124<br />

Milano W 124<br />

Milella M 93<br />

Milton D 100<br />

Minelli A 115<br />

Mini E 50, 55<br />

Miniaci M 55<br />

Minotti G 37<br />

Minutoli L 54, 58, 101, 117, 120,<br />

126, 127, 135, 136<br />

Minutolo A 116<br />

Mioni C 53, 101, 117, 126<br />

Mirabile M 107<br />

Miral<strong>di</strong> E 136<br />

Mirandola P 37, 61, 112<br />

Mirone V 101, 142<br />

Mishra R<br />

Miti<strong>di</strong>eri E 119<br />

Mocaer E<br />

Mochly-Rosen D 55, 80<br />

Modafferi A 94<br />

Modafferi AME 95, 96<br />

Mognetti B 59, 104<br />

Moison D<br />

Moleri E 121<br />

Molin Pradel N<br />

Molinari P 78<br />

Molinaro G 65, 88, 96<br />

Mollace V 44, 84, 93, 128, 146<br />

Molnar J 104, 109<br />

Molteni R 61, 85, 103<br />

Mombelli G 54<br />

Mondaini N 101<br />

Mondelli V 131<br />

Mondello L 146<br />

Mongeau R 93<br />

Monnazzi P 57, 105<br />

Monopoli A 37, 119<br />

Montagnani M 48, 83, 94, 119<br />

Montagnani S 106<br />

Montali M<br />

Montanari C 57, 101, 137<br />

Monteleone P 38<br />

Montesissa C 130<br />

159


Monti E 61, 103<br />

Monti M 118<br />

Monticone M 79<br />

Montinaro E 106<br />

Montopoli M 81, 83<br />

Montorsi F 142<br />

Montuschi P 32<br />

Moore P 48<br />

Moorman A<br />

Morale MC 64, 90<br />

Moran<strong>di</strong> S 95<br />

Morari M 43, 78<br />

Moraschi S 85<br />

Morbidelli L 80, 114, 118, 119,<br />

137<br />

Morelli M 45, 89<br />

Morello S 120, 138<br />

Mores N 127<br />

Moretti S 107, 143<br />

Moretti U 29<br />

Moretto N 91<br />

Morgan C 131<br />

Morgante L 107<br />

Morgese MG 89, 91, 118<br />

Mori M 99<br />

Morigi M 59<br />

Morini G 97, 98<br />

Morley-Fletcher S 123<br />

Moro E 98<br />

Moro S 81<br />

Moroni F 63, 115, 116, 118, 127<br />

Morpurgo M 111<br />

Morreale I 99<br />

Morris J<br />

Morrone LA 65<br />

Morroni F 88<br />

Morsuillo M 107<br />

Mosca F 116<br />

Mosca M 110, 138<br />

Moschini M 29<br />

Mosillo P 77<br />

Mostallino MC 30, 61, 77<br />

Motohashi N 104, 109<br />

Motola D 143<br />

Motolese M 96, 113<br />

Motta A 139<br />

Moulon I 111<br />

Muccioli G 100, 135, 136<br />

Mugelli A 29, 53, 67, 107, 143<br />

Muggironi G<br />

Muià C 38, 66, 103, 133, 138,<br />

145<br />

Mulholland D<br />

Muller C<br />

Muller E<br />

Muntoni AL 31, 95<br />

Muntoni E 106<br />

Muntoni S 88<br />

Mura ML 30, 77<br />

Muraglia M 115<br />

Murgia E 94<br />

Murineddu G 125<br />

Murray RM 131<br />

Murri L 146<br />

Murru L 30, 36, 61, 76, 77, 131<br />

MusanteV 77<br />

Musazzi L 118<br />

Muscatello MR 124<br />

Muscoli C 44, 84, 93, 128<br />

Muscoli S 146<br />

Musiani P 59<br />

Mussa MV 58<br />

Mussoni L 43<br />

Musumeci M 126<br />

Naccari C 144, 145<br />

Nacci C 119<br />

Nannizzi S 147, 103<br />

Nappi G 62, 146<br />

Nassi A 61<br />

Nassini R 83, 101<br />

Nasuti CC 108<br />

Natale G 98, 134<br />

Natale MR<br />

Natali A 101<br />

Nauck MA 99<br />

Nava F 41<br />

Navari S 131<br />

Navarra M 79, 136, 145, 146<br />

Navarra P 123, 136<br />

Navarra T 116<br />

Navarro Mora G 146<br />

Nazzaro C 118, 122<br />

Ndengele M 132<br />

Nebbia C 108<br />

Negri 42, 43, 50, 60, 92, 144<br />

Nencini C 107, 144, 145<br />

Nencini P 86, 93, 95, 96, 97<br />

Neri E 77<br />

Ngomba R 87<br />

Nicchia GP 127<br />

Niccolai N 121<br />

Niccolini C 77<br />

Nico B 127<br />

Nicoletti F 123, 126, 129, 46, 60,<br />

65, 77, 78, 86, 87, 88, 96, 97,<br />

113, 114, 116<br />

Nicoletti P 83, 129<br />

Nicolussi E 50<br />

Niro V<br />

Nisoli E 64<br />

Nisticò G 93<br />

Nisticò S 128<br />

Nistri A<br />

Nistri S<br />

Nizzari M 90<br />

Nobile M 81, 112<br />

Nobili E 43<br />

Norbedo S 110<br />

Norcini M 43, 92<br />

Norppa H 147<br />

Nosi D 125<br />

Notarangelo F 121<br />

Notarbartolo M 37, 104, 110<br />

Noto G 94<br />

Novelli A 63<br />

Novi F<br />

Novick D 141<br />

Nucci C 65<br />

Nunziata A 95<br />

Oberto A 88<br />

Obili N 76<br />

Oddo S 91<br />

Oderda C 137<br />

Oldrini R 98<br />

Olianas MC 86, 126<br />

Olimpieri F 121<br />

Oliva P 84<br />

Oliverio M 93<br />

Olivieri R 119<br />

Olivieri F<br />

Olla A 96<br />

Onali P 58, 65, 86, 111, 126<br />

O'Neill RD<br />

Ongini E 142<br />

Onor ML<br />

Onorati F 120<br />

Opasich F 84<br />

Ori C 107<br />

Oria C 143<br />

Orlan<strong>di</strong> P 81, 138<br />

Orlan<strong>di</strong>ni C 59<br />

Orlando Rocco<br />

Orlando Rosamaria 96, 113, 142<br />

Orlotti D 132, 133<br />

Orrù Marco<br />

Orrù Marisa 94<br />

Orsini F 109<br />

Osella D 103, 104<br />

Otar G<br />

Oteri A 95, 97, 111, 144<br />

Ottani A 126<br />

Pace S 96<br />

Pacifici R 96<br />

Paganelli P 88<br />

Pagetta A 37<br />

Pagotto U 76<br />

Paizis G 136<br />

Palatini P 142<br />

Palazzo E 92, 129<br />

Palleria C 106<br />

Palma E 84, 87,146<br />

Palmi I 97<br />

Palmi M 78<br />

Palomba D 108<br />

Palombo C<br />

Paluzzi P 62, 79, 112,<br />

Paluzzi S 81<br />

Panaccione I 86<br />

Panerai AE 129, 43, 96<br />

Pani G 128,<br />

Pani L 76, 93, 104, 121, 123, 125<br />

Panin F 36<br />

Panini S<br />

Panlilio LV 125<br />

Pannacci M 110, 139<br />

Pantalone D 59<br />

Panuzzo C 140<br />

Panza Elisa 81<br />

Panza L 140<br />

Paoletti T 146<br />

Paoletti AM 62<br />

Paolini M 108, 134<br />

Papaluca Amati M 111<br />

Papi A 133<br />

Papotti M 59<br />

Papparella I 119<br />

Para<strong>di</strong>so B 117, 146<br />

Parati E 60<br />

Par<strong>di</strong>ni C 89<br />

Parente L 55, 59, 64, 79, 102,<br />

138<br />

Parenti A 5, 48, 59<br />

Pariante C 131<br />

Parini F 106<br />

Parolari A 119<br />

Parolaro D 31, 34, 61, 80<br />

Parolini C<br />

Parrinello G 106<br />

Pascale A 98<br />

Pascotto A 35<br />

Pasinetti GM 124<br />

Pasqualetti G 103<br />

Passamonti S 119<br />

Passani MB 114, 125<br />

Pastoris O 84, 99, 142<br />

Pasut G 111<br />

Patacchini R 83, 101, 120<br />

Patacchioli FR 57, 105<br />

Patanè M 114<br />

160


Patrignani P 47, 54, 84, 102<br />

Patrono C 29, 40<br />

Pattarozzi A 79<br />

Patti L 36, 82<br />

Pau A 125<br />

Peana AT 135<br />

Pedata F 35, 60, 61, 113<br />

Peddes C<br />

Pedrazzani C 138<br />

Pedrelli M 121<br />

Pegoraro P 142<br />

Pelaia G 80<br />

Pellegrini-Giampietro D 63, 77,<br />

115, 116, 118<br />

Pelosi V 57, 83<br />

PengoV 107<br />

Pennisi G 81<br />

Pepicelli O 82<br />

Pepponi R<br />

Pergola C 102, 144<br />

Peri F 129<br />

Perletti G 61<br />

Perna F 80<br />

Perra S 31<br />

Perretti M 102<br />

Perrissoud D 136<br />

Perrone S 127<br />

Perrotta C<br />

Perrotta I 126<br />

Perseu MG<br />

Perucca E 30<br />

Perusin M 50<br />

Pessina F 127<br />

Pestarino M 79<br />

Peters GJ 147<br />

Petrella A 59, 138<br />

Petrella Carla 98<br />

Petrella Clau<strong>di</strong>o 124, 135, 93, 99<br />

Petrillo P 43<br />

Petris G 119<br />

Petrò R 76<br />

Petroni A 124<br />

Petroni S<br />

Pezzatini S 118<br />

Pèzzola A 82<br />

Pezzolla F 135<br />

Pfister P 121<br />

Picano E<br />

Piccar<strong>di</strong> MP 46, 147<br />

Piccinin S 114<br />

Piccione F 58<br />

Piccoli A 47<br />

Picerno P 108<br />

Pichini S 97<br />

Picollo A 115<br />

Piegari E 115, 37, 84<br />

Pieratti A 107, 95<br />

Pieretti S 122, 144, 42, 93<br />

Pierno S 115<br />

Pietrini V 91<br />

Pignataro G 126, 63<br />

Pigneri A<br />

Pillolla G 31<br />

Pilloni M<br />

Pilotto A 42<br />

Pincelli C 137<br />

Pinchera A 113<br />

Pinetti D 105, 139<br />

Pini L 129, 92<br />

Pinna A 89<br />

Pinna C 83<br />

Pinna GA 125<br />

Pinna Spada G 123, 76<br />

Pino R<br />

Pinto A 119, 138, 82<br />

Pintor A 82<br />

Piomelli D 129, 132, 34<br />

Pippia P 135<br />

Piras AP 94<br />

Pirozzi Farina F 142<br />

Pirro E 58<br />

Pisa S 130<br />

Pistis M 31, 95<br />

Pistotti V 144<br />

Pisu MG 36, 88, 95<br />

Pittaluga A 44, 77<br />

Pittau B 121<br />

Pitzalis S 111<br />

Pitzianti S 76<br />

Pizza V 129, 130<br />

Plescia F 94, 95<br />

Pluchino S 79, 90<br />

Poggi L 99<br />

Poggiani C 117, 78<br />

Poggioli R 101<br />

Polenzani L 102<br />

Polidori C 122, 97<br />

Polimeni G 111, 144, 29, 99<br />

Polito F 101, 120, 135, 136, 54,<br />

58<br />

Polli F 65<br />

Pollicita M<br />

Poma P 104, 110, 37<br />

Pomelli D<br />

Pompella G<br />

Pons S 117, 30<br />

Pontis S 89<br />

Ponzetto C 136<br />

Popoli P 118, 28, 46, 82<br />

Popolo A 120, 138<br />

Poppi B 130<br />

Porcile C 79<br />

Porcu E 30<br />

Porreca E 54<br />

Porticella E 97<br />

Potenza MA 48, 83<br />

Potenza RL<br />

Potenza S 107<br />

Potì F 121<br />

Poulet R 119<br />

Powell J 131<br />

Pozzesi N 140<br />

Pozzetti L 108<br />

Pozzi E 110<br />

Pozzoli G 123<br />

Presotto C 119<br />

Preti D<br />

Preziosi P 127, 128, 81, 97<br />

Priora R 108, 120, 121<br />

Procacci P 129<br />

Procopio S 136<br />

Proietti F 127<br />

Provenzani A 110<br />

Provenzano GM 94, 95<br />

Puccetti P<br />

Puddu I<br />

Puggioni G 36, 94<br />

Pugliese AM 113, 35<br />

Puia G 77<br />

Pulighe E 135<br />

Pusch M 115<br />

Putzu P 146, 26<br />

Qasem AR 137<br />

Quarto C 120<br />

Quintana H 141<br />

Quintieri L 61<br />

Quon MJ 48<br />

Racagni G 28, 38, 85, 86, 118<br />

Racca S 108<br />

Racchi M 137<br />

Racioppi A 100<br />

Ra<strong>di</strong>ce S 108<br />

Raffa R 88<br />

Raffaeli W 130<br />

Ragazzi E 81<br />

Ragusa S 146<br />

Raiteri L 81, 82<br />

Raiteri M 36, 77, 82<br />

Rammes G 118<br />

Ranzani D 111<br />

Rasini E 50, 139, 140<br />

Ratcliffe M 141<br />

Ravasio G 130<br />

Ravizza R 103, 61<br />

Reali C 85<br />

Reali R 125<br />

Realini N 61<br />

Reggiani A 50, 76<br />

Regoli D 49, 78, 93, 114, 122<br />

Reimondo G 58<br />

Reitano E 44<br />

Remaley A 84<br />

Renda T 80<br />

Rende P 106<br />

Renna G 36<br />

Renzulli A 120<br />

Renzulli M 147<br />

Repetto E 90<br />

Restivo A 93<br />

Ribichini F 37<br />

Riccar<strong>di</strong> C 39, 55, 58, 80, 103,<br />

137, 140<br />

Ricchi L 57, 58, 102<br />

Ricci S 59<br />

Ricciar<strong>di</strong> S 103, 147<br />

Richelmi P 117<br />

Rigamonti AE 135<br />

Rigamonti E 48<br />

Rigatti P 142<br />

Righetti L 125<br />

Rimon<strong>di</strong>ni R 123, 132<br />

Rinal<strong>di</strong> B 37, 47, 107, 120<br />

Rinal<strong>di</strong> M 148<br />

Riozzi B 65, 88, 97<br />

Riva MA 28, 56, 85, 86<br />

Rivas E 96<br />

Rivasi F 31, 125<br />

Rivasi M 79, 101<br />

Rivera M 131<br />

Rizzi A 78, 93, 122<br />

Rizzi M 37<br />

Rizzo G 54<br />

Rizzo M 93<br />

Rizzo V 88, 117<br />

Robbiano L 109<br />

Roberts A 100<br />

Roberts D 30<br />

Robino F 36, 82<br />

Rocca A<br />

Rocchitta G 36, 64, 79, 90, 94<br />

Rodella LF 129<br />

Ro<strong>di</strong> D 122, 146<br />

Ro<strong>di</strong>nò P<br />

Rodolico G 84, 115, 37<br />

Rodriguez J 147<br />

Rodriguez M 59<br />

Roi C 143<br />

Rolf Sprengel 88<br />

Rolland JF 114, 127<br />

161


Romagnino S<br />

Romagnoli P 47<br />

Romani A 140<br />

Romano MR 78<br />

Rombolà L 65<br />

Romeo C 101<br />

Romeo F 146<br />

Romual<strong>di</strong> P 92, 97<br />

Romussi G 144<br />

Roncarati R 92<br />

Ronchetti D 102<br />

Ronchetti F 140<br />

Roozendaal B 94<br />

Rosa AC 58<br />

Rosa P<br />

Rosato A 61<br />

Rosi MC 90<br />

Rossi A 63, 102, 141, 142, 144<br />

Rossi F 32, 37, 38, 43, 47, 52,<br />

84, 92, 120, 129, 132, 133, 144<br />

Rossi G 109<br />

Rossi M 113<br />

Rossi T 103, 139<br />

Rossini C 129<br />

Rossitto A 99<br />

Rossoni G 48, 83, 84, 97, 121<br />

Rotiroti D 84, 87, 93, 128, 146<br />

Rovati G 102, 133<br />

Roviello F 138<br />

Roviezzo F 54, 83, 133<br />

Ruberto A 139<br />

Ruberto G 145<br />

Rubino T 31, 61<br />

Ruco L 138<br />

Ruffilli MP 39, 46<br />

Ruggero G 128<br />

Ruggieri V 92, 122<br />

Ruiu S 125<br />

Runci F 128<br />

Rundle-Smith S 124<br />

Ruozi B 125<br />

Russier J 120<br />

Russo A 111, 144<br />

Russo D 79, 136<br />

Russo E 79, 86, 136<br />

Russo F 142, 144<br />

Russo G 95, 130<br />

Russo M 132, 133<br />

Russo R 42, 44, 50, 128, 129<br />

Russo T 65, 90<br />

Russo E 86, 87, 126<br />

Rustichelli C 121<br />

Saba F 85<br />

Saccani F 118<br />

Sacchetti G<br />

Sacchetto E<br />

Sacchetto V 61, 112, 133<br />

Sacco I 146<br />

Saccomanni G 105<br />

Sacerdote P 42, 43, 49, 96, 129<br />

Saglio G 140<br />

Saija A 128, 144, 145<br />

Sala A 101, 119<br />

Sala M 61, 97<br />

Salani G 90<br />

Salemi M 96<br />

Salis B 65, 111<br />

Salton S 124<br />

Salucci S 115<br />

Salvadori M 137<br />

Salvadori S 93<br />

Salvati P 93<br />

Salvatorelli E 37<br />

Salvemini D 93, 132<br />

Salvetti A 106<br />

Salvo F 95, 99, 143, 144<br />

Sances G 105<br />

Sancesario G<br />

Sancini G 117<br />

Sandrini M 92<br />

Sanguedolce G 138<br />

Sanguedolce R 138<br />

Sani M 104<br />

Sanna A 76, 104<br />

Sanna E 30, 36, 45, 61, 76, 77,<br />

131<br />

Sanna F 101, 130<br />

Santè P 120<br />

Santillo M<br />

Santolini I 87<br />

Santoro A 108<br />

Santoro V 124<br />

Santoru F 88<br />

Sanvito P<br />

Saponara S 104<br />

Sapone A 108<br />

Saporiti F 50<br />

Saramin C 48<br />

Sardo P 88<br />

Sarichelou I 77<br />

Sarnataro D 76<br />

Sarti D 130<br />

Sartiani L 44<br />

Sartori MF 111<br />

Sasso O 42, 50, 128, 129<br />

Satriano C 118<br />

Sautebin L 102, 143, 144<br />

Savani C 43, 90, 91<br />

Saviano R 136<br />

Savica R 107<br />

Savino R 80<br />

Scaccianoce S 86, 94, 95, 96<br />

Scafuro MA 92<br />

Scaglione F 32, 34, 110, 139<br />

Scaldaferri E 48<br />

Scali C 92<br />

Scandroglio P 76<br />

Scaramuzza S 110<br />

Scarcelli C<br />

Scarfone S 87<br />

Scartabelli T 115, 116<br />

Scatigna M 52, 141<br />

Schelling G 94<br />

Schembri L 139, 140<br />

Schenone S 79, 136<br />

Scherma M 31<br />

Schettini G 79, 90<br />

Schiano Moriello A 76<br />

Schiavo G 129<br />

Schiavone S 90<br />

Schiavone N 80<br />

Schillani G 147<br />

Schintu N 89<br />

Schirru C 39, 148<br />

Scholl CA 95<br />

Schrepfer R 111<br />

Schuh K 141<br />

Scicchitano F 86<br />

Sciorati C<br />

Sciulli MG 84<br />

Scorciapino L 85<br />

Scordo MG<br />

Scorziello A 63<br />

Scotto P 136<br />

Scuderi C 43, 90, 91<br />

Scuderi MR<br />

Sculco F 146<br />

Sebastiao AM<br />

Sechi GP<br />

Secondo A 81<br />

Seghieri G 100<br />

Selis F 111<br />

Selvatici R 113<br />

Serafino A 120<br />

Sergi M 111<br />

Serio S 106<br />

Seripa D<br />

Serpe L 104, 111<br />

Serpi A 142<br />

Serra G 57, 94<br />

Serra M 36, 56, 88, 95<br />

Serra 36, 64<br />

Serra V 77<br />

Servid<strong>di</strong>o G 91<br />

Sessa E<br />

Severi P 77<br />

Severino G 147<br />

Sgadò P 89<br />

Sgaragli G 104, 109, 127<br />

Sgaragli T 104<br />

Sgorbini M 105<br />

Sgroi C 111<br />

Sgura A 44<br />

Shah A 104, 109<br />

Shanton F<br />

Shapiro MS 35<br />

Sheen V 90<br />

Sibilia V 98<br />

Sicuteri R 142<br />

Sigala S 106<br />

Signori E 148<br />

Silvestro A 111<br />

Simeon V 111<br />

Simeoni S 57, 105<br />

Simioni C 37, 112, 133<br />

Simola N 89, 96<br />

Simonato M 30, 117, 122, 146<br />

Simoncini T 62<br />

Simoni D 37<br />

Sindona G<br />

Siniscalchi Anna 122<br />

Siniscalchi Antonio 105, 142<br />

Siniscalco D 43, 129<br />

Siracusano MR<br />

Sirca D 131<br />

Sirigu R 85<br />

Sironi L 43, 126<br />

Sirtori C 48, 54<br />

Sitzia F 77<br />

Smid K 147<br />

Smits J 33<br />

Soffia S 78<br />

Sofianos I 36<br />

Soglian A 98<br />

Sogliano C 88<br />

Sogos V 85<br />

Sokolova E<br />

Soldani G 105<br />

Soldovieri MV<br />

Solenghi E<br />

Soleti A 134<br />

Solinas M 31, 125<br />

Solito E 79<br />

Solito R 91, 114<br />

Sollai L 111<br />

Soma R 143<br />

Somaini L 96<br />

Sommer W 132<br />

Sor<strong>di</strong> A 53<br />

162


Sorrentino Raffaella<br />

Sorrentino Rosalinda<br />

Sortino MA 60<br />

Soverchia L 123<br />

Spaccamiglio A 108<br />

Spadaro M 59<br />

Spagnolo B 78, 122<br />

Spampinato S 58, 113, 123, 130,<br />

137<br />

Spampinato U 51<br />

Spano PF 55, 106<br />

Spano MS 30, 130<br />

Sparatore A 48<br />

Sparnacci K 103<br />

Spartà AM<br />

Speciale A 109, 128<br />

Spina O<br />

Spina S<br />

Spina E 30, 107, 124<br />

Spinsanti P 65, 78<br />

Spinzia C 128<br />

Spisani S 113<br />

Sportiello L 143<br />

Sprio AE 58<br />

Squadrito F 54, 58, 101, 117,<br />

120, 126, 127, 135, 136<br />

Squassina A 146, 147<br />

Stark H 98<br />

Starowicz K 76, 100<br />

Stasi MA 86<br />

Steardo L 43, 90, 91, 98<br />

Stein EA<br />

Stephan H<br />

Sternieri E 105, 130<br />

Sternini C 135<br />

Steven C 81<br />

Sticozzi C 78<br />

Stillitano F<br />

Stocco A 107<br />

Stocco G 109, 110<br />

Stocchino ME<br />

Stopponi S 97, 132<br />

Storm-Mathisen J<br />

Storto M 88, 97<br />

Straface E 57<br />

Straub RH<br />

Stroik J 31<br />

Strongoli C<br />

Strongoli MC 87<br />

Suarez D 141<br />

Succu S 101, 130<br />

Suffre<strong>di</strong>ni S<br />

Sullo N 110, 132, 133, 139<br />

Sumberaz A 108<br />

Summa D 108, 120, 121<br />

Sumner C 141<br />

Sutton V 141<br />

Suzuki H<br />

Svensson HT<br />

Tabrizi MA 89<br />

Tabucchi A 117<br />

Tacchetti C 90<br />

Tacchi R 31, 125,<br />

Tacchi S 125<br />

Tacconelli S 54, 84, 102<br />

Taglialatela M 35, 37, 45, 81<br />

Talani G 36, 77<br />

Tambaro S 121<br />

Tamborra R 91<br />

Tamburella A 117<br />

Tamiazzo L 136<br />

Tammaro E 124<br />

Tanda G 86<br />

Tanganelli S<br />

Tani C 110<br />

Tanzarella C<br />

Tar<strong>di</strong>to D 118, 85<br />

Tari M 143<br />

Tari U 143<br />

Tarozzi A 88<br />

Tarquini E 137<br />

Tarquinio M 48, 119<br />

Tarzia G 132<br />

Tascedda F 62, 85<br />

Tasdemir E 116<br />

Tatarelli R 86<br />

Taylor G 65, 110, 111<br />

Tazzari V 48<br />

Tebano MT 82<br />

Tedesco M 130<br />

Tekle C 147<br />

Temperilli F 95<br />

Terdoslavich M 119<br />

Teresa M 118<br />

Terragna C 147<br />

Terrazzani G 48<br />

Terstappen G 92<br />

Terzolo M 58<br />

Terzuoli E 113<br />

Tesi F 100<br />

Testa M 142<br />

Testa N 57, 64, 90<br />

Testino G 108<br />

Thellung S 79<br />

Thiemermann C 48, 133<br />

Thorsten B<br />

Tiraboschi E 85<br />

Tirolo C 90<br />

Tita B 104<br />

Togna AR 120<br />

Togna G 96<br />

Tognolini 134<br />

Tolu S 30<br />

Tomaino A 109, 144<br />

Tomasini MC 65<br />

Tommasini I<br />

Tonacchera M 113<br />

Tonachini L 79<br />

Tonazzini I<br />

Tonini A 132<br />

Tonini M 42, 60, 99, 133, 135<br />

Tonini S 133<br />

Tonon G 65, 111, 148<br />

Torres Y 114<br />

Torsello A 136<br />

Torta R 66<br />

Tortiglione A 126<br />

Tortorella P 115<br />

Tortorella V 114<br />

Toscano A 116<br />

Tosco A 59<br />

Tosi A 112, 133<br />

Tosi G 31, 125<br />

Totani L 47<br />

Tozzi M 139<br />

Trabace L 57, 90, 91<br />

Traficante A 65<br />

Traini C 113<br />

Tramentozzi E 37<br />

Trapella C 78<br />

Trautman M 99<br />

Traversa S 137<br />

Trefiletti G 96<br />

Tremoli E 38, 43, 53, 54, 119,<br />

126<br />

Trevisani M 99, 120, 129, 131,<br />

132<br />

Trevisi L 78<br />

Trezza V 31, 94<br />

Tricarico D 45<br />

Trifirò G 124, 143<br />

Trimarco B 110<br />

Trimarco V 110<br />

Trincavelli ML 35<br />

Tringali G 123, 136<br />

Triolo F 110<br />

Trisolini P 135<br />

Trombetta D 145<br />

Tronci E 89<br />

Trovato AE 129<br />

Tucci P 57<br />

Tuccori M 29, 143, 144<br />

Tumminello FM 138<br />

Turriziani M 104<br />

Ubal<strong>di</strong> M 123<br />

Uberti D 65<br />

Uccelli A 82<br />

Uliva C 132, 142<br />

Ullu LM 86<br />

Uras Roberta 77<br />

Ursino MG 134<br />

Usai C 82<br />

Uvec Group 143<br />

Uziel G 124<br />

Uzzo M 119<br />

Vacca F<br />

Vaglini F 89<br />

Vago T 119<br />

Vairetti M 117<br />

Valenti LP 106<br />

Valenti M 80<br />

Valenti S 104<br />

Valentini V 86, 96<br />

Valeri A 127<br />

Valle G 60<br />

Valoti M 104, 109<br />

Valsecchi AE 129<br />

Valsecchi V 126<br />

Valtancoli B 102<br />

Van Gaal LF 99<br />

Van Luijtelaar G 87<br />

Vanacore N 107<br />

Vandelli MA 31, 125<br />

Vanderschuren LJMJ 31<br />

Vannacci A 29, 107, 143<br />

Vannucchi MG 61<br />

Varani K 28, 37, 61, 112, 133<br />

Varano E 136<br />

Vargiu G 136<br />

Varoni MV 108<br />

Vasina V 134<br />

Vassanelli C 37<br />

Vecchio I 87, 128<br />

Vecchione C 113<br />

Vegeto E 57, 103<br />

Velar<strong>di</strong> E 58, 80, 137<br />

Vella S 39, 46, 52<br />

Vellecco V 54, 83, 133<br />

Venco A 139, 140<br />

Vendemiale G 91<br />

Venezia V 90<br />

Ventrice D<br />

Ventura A 109, 110<br />

Verderio C 35, 81<br />

Vergoni AV 31, 125<br />

Vergura R 93<br />

Veronese F 111<br />

Verri M 84, 142, 99<br />

163


Vetrice D 93, 128<br />

Vettorato E 130<br />

Vezzalini F 137<br />

Viaggi C 89<br />

Viano I 57, 104<br />

Viaro R 43<br />

Viganò D 31, 61<br />

Vighi E 99<br />

Viglio S 142<br />

Villa G<br />

Villa LM 146<br />

Villa R 130<br />

Villa RF 89<br />

Villa V 79<br />

Villarosa F 95<br />

Villetti G 91<br />

Vincenzi F 112, 133<br />

Vinci MC 48, 54, 59<br />

Vinci S 96, 130<br />

Viola S 80<br />

Vir<strong>di</strong>s A 134<br />

Vir<strong>di</strong>s F 131<br />

Visalli V 84, 128, 146<br />

Vita D 92<br />

Vita G 127<br />

Vitale G 92, 122<br />

Vitali F 104<br />

Vitellaro-Zuccarelli L 102<br />

Vitelli MR 84, 37<br />

Vitiello M 102<br />

Vitti P 113<br />

Viviani B 44<br />

Vivoli E 43, 92, 116<br />

Vizzini G 110<br />

Volonté C 35<br />

Volonterio A 121<br />

Volpe AR 60, 109<br />

Volpe Giampiero 129, 130<br />

Volpe Gisellla 140<br />

Volpi I 146<br />

Volpini R 35<br />

Volta R 91<br />

Volta U 99<br />

Volterra A<br />

Wang J 124<br />

Wang ZQ 66<br />

Warne J<br />

Weksler BB 54<br />

Wertheim CE 31<br />

Widel MH<br />

Wilson S<br />

Wotjak CT 47<br />

Wren P<br />

Yasar S 125<br />

Yemul S 124<br />

Zaccheddu R 36<br />

Zafar B<br />

Zaffani S 107<br />

Zaffaroni M 50<br />

Zaffe D 117, 126<br />

Zaggia B 58<br />

Zagli G 83, 120, 129<br />

Zagotto G 81<br />

Zambon A 40<br />

Zambrano N 65<br />

Zanda M 104, 121<br />

Zanelli U 92<br />

Zanetti E 98<br />

Zangla A 111<br />

Zani A 61, 97<br />

Zaninetti R 125<br />

Zanoli P 57, 101, 137<br />

Zanotti I 121<br />

Zappettini Simona<br />

Zappettini Stefania 36, 81, 82<br />

Zara G 104, 106, 111<br />

Zavatti M 57, 101, 137<br />

Zecchi S 131<br />

Zeppegno P 35<br />

Zhang J 66<br />

Zhao Z 124<br />

Ziche M 55, 80, 91, 101, 113,<br />

114, 118, 119, 137<br />

Zieglgansberger W 118<br />

Zinellu A 57<br />

Zinman B 100<br />

Zoccali R 124<br />

Zoja C 43<br />

Zonca A 130<br />

Zonta F 117<br />

Zoppellaro C 134<br />

Zotti M 123<br />

Zucca S<br />

Zuccaro P 97<br />

Zucchini S 117, 122, 146<br />

Zuccotti A 137<br />

Zuddas A 56<br />

Zuena AR<br />

Zupi G 138<br />

Zusso M 78, 86<br />

164


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