Programma finale completo - SIF - Università degli Studi di Torino
Programma finale completo - SIF - Università degli Studi di Torino
Programma finale completo - SIF - Università degli Studi di Torino
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Wyeth:<br />
la ricerca<br />
nasce qui<br />
●<br />
Aprilia<br />
Sede legale<br />
Stabilimento Produzione Farmaceutica<br />
●<br />
Catania<br />
Stabilimento Produzione Farmaceutica<br />
Agricoltura Veterinaria<br />
Centro Ricerche:<br />
- Wyeth European Drug Safety and Metabolism Center<br />
La cultura della salute<br />
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38<br />
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Cre<strong>di</strong>ti ECM assegnati 5<br />
Corso <strong>di</strong> Aggiornamento<br />
Il contributo della farmacologia al trattamento della depressione<br />
SALA 5<br />
09.00-17.00<br />
Moderatori: Carpiniello B (Cagliari) Putzu P (Cagliari)<br />
26<br />
09.00/09.15 Carpiniello B (Cagliari)<br />
Apertura e introduzione<br />
09.15/10.00 Guazzelli M (Pisa)<br />
Diagnosi e classificazione dei <strong>di</strong>sturbi depressivi: vali<strong>di</strong>tà e limiti<br />
dell'approccio clinico-descrittivo<br />
10.00/10.45 Sorbi S (Firenze)<br />
Depressione in corso <strong>di</strong> malattie neurologiche: fattore negativo per la<br />
prognosi?<br />
11.15/12.00 Biggio G (Cagliari)<br />
Presente e futuro <strong>degli</strong> antidepressivi<br />
12.00/12.30 Discussione<br />
12.30/13.00 Workshop<br />
Guazzelli M (Pisa)<br />
Presentazione caso clinico A<br />
Sorbi S (Firenze)<br />
Presentazione caso clinico B<br />
14.00/15.00 Guazzelli M (Pisa) Carpiniello B (Cagliari)<br />
Elaborazione del caso clinico<br />
15.00/16.00 Sorbi M (Firenze) Putzu P (Cagliari)<br />
Presentazione del caso clinico<br />
16.30/17.00 Putzu P (Cagliari)<br />
Conclusioni e questionario ECM<br />
Realizzato con il contributo educazionale <strong>di</strong> Lundbeck<br />
pag_sx.indd 1 29/05/2007 23.41.25
Cerimonia Inaugurale<br />
AUDITORIUM<br />
18.00-19.00<br />
Saluto delle Autorità<br />
Lettura Inaugurale<br />
Moderatore : Biggio G (Cagliari)<br />
Sessione ECM<br />
Hokfelt T (Karolinska Institute, Stockholm)<br />
Three decades with three Swe<strong>di</strong>sh neuropeptides: focus on pain and depression<br />
AUDITORIUM<br />
19.00-20.00<br />
Cocktail <strong>di</strong> Benvenuto<br />
20.00-22.00<br />
27<br />
pag_dx.indd 1 29/05/2007 23.47.24
28<br />
Simposio<br />
Vecchi e nuovi antipsicotici a confronto<br />
(<strong>SIF</strong> - SINPF)<br />
Moderatori: Nivoli G (Sassari) Racagni G (Milano)<br />
08.30/08.50 Riva MA (Milano)<br />
Diversità dei meccanismi d'azione<br />
08.50/09.10 Altamura CA (Milano)<br />
Il trattamento acuto<br />
09.10/09.30 Bellantuono C (Verona)<br />
Il trattamento cronico<br />
09.30/09.50 Mencacci C (Milano)<br />
Antipsicotici e genere<br />
09.50/10.10 Aguglia E (Trieste)<br />
I farmaci antipsicotici nel BPSD<br />
10.10/10.30 Balestrieri M (U<strong>di</strong>ne)<br />
Antipiscotici e <strong>di</strong>sturbi <strong>di</strong> personalità<br />
10.30/10.45 Discussione<br />
10.45/11.00 Nivoli G (Sassari)<br />
Conclusioni<br />
Sessione ECM<br />
Cre<strong>di</strong>ti ECM assegnati 4<br />
Simposio<br />
Modulazione farmacologica dei recettori P 1<br />
(<strong>SIF</strong> - Gruppo Nazionale Adenosina)<br />
Moderatori: Borea PA (Ferrara) Caciagli F (Chieti)<br />
08.30/08.50 Baral<strong>di</strong> PG (Ferrara)<br />
Nuovi agonisti e antagonisti del recettore adenosinico A 2B<br />
AUDITORIUM<br />
08.30-11.00<br />
SALA 1<br />
08.30-11.00<br />
08.50/09.10 Popoli P (Roma)<br />
Ruolo dei recettori A 2A dell'adenosina nella modulazione <strong>di</strong> effetti neurotrofici in<br />
con<strong>di</strong>zioni fisiologiche e patologiche<br />
09.10/09.30 Melani A (Firenze)<br />
Neuroprotezione <strong>degli</strong> antagonisti A 2A durante ischemia<br />
09.30/09.50 Martini C (Pisa)<br />
Interazione funzionale tra recettori dell'adenosina e recettori dopaminergici: ruolo<br />
nella terapia antipsicotica<br />
09.50/10.10 Carta A (Cagliari)<br />
Antagonisti per i recettori A 2A adenosinergici: una promettente terapia sintomatica e<br />
neuroprotettiva per la malattia <strong>di</strong> Parkinson<br />
10.10/10.30 Varani K (Ferrara)<br />
Alterazione dei recettori dell'adenosina in pazienti con broncopneumopatia cronica<br />
ostruttiva<br />
10.30/10.50 Capecchi PL (Siena)<br />
Sistema adenosinergico e polimorfismi genetici: possibili implicazioni cliniche in<br />
ambito car<strong>di</strong>ovascolare<br />
10.50/11.00 Discussione<br />
pag_sx.indd 1 01/06/2007 14.56.01
Sessione ECM<br />
Simposio<br />
Efficacia e sicurezza <strong>di</strong> FANS tra<strong>di</strong>zionali e COXIB<br />
Moderatori: Mugelli A (Firenze) Patrono C (Roma)<br />
08.30/08.50 Patrono C (Roma)<br />
Farmacologia clinica <strong>degli</strong> inibitori delle ciclo-ossigenasi<br />
08.50/09.10 Lanas A (Saragoza)<br />
Clinical consequences of cyclooxygenase inhibition on the upper and lower<br />
gastrointestinal tract<br />
SALA 2<br />
08.30-11.00<br />
09.10/09.30 Baigent C (Oxford)<br />
Risk of myocar<strong>di</strong>al infarction, stroke and vascular death associated with coxibs and<br />
tra<strong>di</strong>tional NSAIDs<br />
09.30/11.00 Tavola Rotonda<br />
Quesiti aperti e priorità in tema <strong>di</strong> ricerca clinica e <strong>di</strong> scelte terapeutiche<br />
Simposio<br />
<strong>SIF</strong> e informazione in<strong>di</strong>pendente sul farmaco<br />
(Sezione <strong>di</strong> Farmacologia Clinica)<br />
Moderatori: Caputi AP (Messina) Velo GP (Verona)<br />
08.30/08.50 Ad<strong>di</strong>s A (Roma)<br />
L'Agenzia del Farmaco<br />
08.50/09.05 Moretti U (Verona)<br />
Focus (ISBD)<br />
Sessione ECM<br />
09.05/09.20 Polimeni G (Messina)<br />
www.farmacovigilanza.org: portale sulla farmacovigilanza<br />
09.20/09.35 Moschini M (Firenze) Vannacci A (Firenze) Tuccori M (Pisa)<br />
Segnalazione spontanea <strong>di</strong> ADR ed informazione <strong>di</strong> ritorno in Toscana<br />
09.35/09.50 Filippelli A (Napoli)<br />
L'esperienza del Centro Regionale <strong>di</strong> Farmacovigilanza della Campania<br />
09.50/10.05 Del Zompo M (Cagliari)<br />
La farmacologia <strong>di</strong> consultazione in Sardegna<br />
10.05/10.20 Tragni E (Milano)<br />
SEFAPNEWS<br />
10.20/10.40 Font M (Verona)<br />
Dialogo sui farmaci<br />
10.40/11.00 Discussione generale<br />
SALA 3<br />
08.30-11.00<br />
29<br />
pag_dx.indd 1 30/05/2007 0.53.23
Sessione ECM<br />
Simposio<br />
Dalle scienze <strong>di</strong> base alla scoperta <strong>di</strong> nuove terapie per l'epilessia<br />
(<strong>SIF</strong> - LICE)<br />
Moderatori: Perucca E (Pavia) De Sarro G (Catanzaro) Marrosu F (Cagliari)<br />
SALA 4<br />
08.30-11.00<br />
08.30/08.50 De Sarro G (Catanzaro)<br />
Gli attuali modelli sperimentali <strong>di</strong> epilessia sono appropriati per in<strong>di</strong>viduare nuovi<br />
agenti antiepilettici?<br />
08.50/09.10 Marrosu F (Cagliari)<br />
Meccanismi molecolari attivati dalla stimolazione vagale<br />
09.10/09.30 Simonato M (Ferrara)<br />
Fattori neurotrofici veicolati da vettori virali: un nuovo approccio?<br />
09.30/09.50 Perucca E (Pavia)<br />
Nuove molecole in sviluppo clinico: una visitazione critica<br />
09.50/10.10 Spina E (Messina)<br />
Utilità dei farmaci antiepilettici in altre in<strong>di</strong>cazioni terapeutiche: esperienze e<br />
prospettive<br />
10.10/11.00 Discussione<br />
30<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Farmacologia delle sostanze d'abuso<br />
Moderatori: Bertolini A (Modena) Cuomo V (Roma)<br />
SALA 5<br />
08.30-11.30<br />
Genedani Susanna 1 , Agnati L.F. 1 , Filaferro M. 1 , Carone C. 1 , Guidolin D. 2 , Roberts D.C.S. 3 ,<br />
Marcellino D. 4 , Fuxe K. 4<br />
1 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena; 2 Dipartimento<br />
<strong>di</strong> Anatomia e Fisiologia Umana, Università <strong>di</strong> Padova; 3 Department of Physiology and Pharmacology,<br />
Wake Forest University School of Me<strong>di</strong>cine, Winston-Salem, USA; 4 Department of Neuroscience,<br />
Karolinska Institutet, Stockholm, Sweden<br />
Influenza della cocaina sui recettori A2A e D2: stu<strong>di</strong> in vivo e in vitro.<br />
Fattore Liana 1,3 , Pons S. 4 , Cossu G. 2,3 , Tolu S. 4 , Porcu E. 2 , Changeux J-P. 4 , Fratta W. 1,2,3 ,<br />
Maskos U. 4<br />
1 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari; 2 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong><br />
Cagliari; 3 Centro <strong>di</strong> Eccellenza "Neurobiologia delle Dipendenze", Università <strong>di</strong> Cagliari; 4 Unité<br />
Récepteurs et Cognition, URA CNRS 2182, Institut Pasteur, Paris Cedex 15, France<br />
Le subunità beta-2 e alfa-4, ma non alfa-7, del recettore nicotinico nella VTA sono necessarie e<br />
sufficienti per il rinforzo da nicotina.<br />
Fadda Paola 1,2 , Spano M.S. 1,2 , Cossu G. 1,2 , Fattore L. 2,3 , Fratta W. 1,2,3<br />
1 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari e 2 Centro <strong>di</strong> Eccellenza "Neurobiologia delle<br />
Dipendenze", Università <strong>di</strong> Cagliari; 3 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari<br />
L’agonista GABA B baclofen previene le ricadute all’abuso <strong>di</strong> sostanze: evidenze precliniche.<br />
Mostallino Maria Cristina1, Mura M.L. 2 , Maciocco E. 2 , Murru L., Sanna E. 2,3 , Biggio G.<br />
1 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari; 2 Dipartimento <strong>di</strong> Biologia Sperimentale sezione<br />
Neuroscienze, Università <strong>di</strong> Cagliari; 3 Centro <strong>di</strong> Eccellenza "Neurobiologia delle Dipendenze",<br />
Università <strong>di</strong> Cagliari<br />
Astinenza da etanolo e plasticità del recettore GABA A.<br />
pag_sx.indd 1 04/06/2007 11.35.27
Tacchi Raffaella 1 , Vergoni A.V. 3 , Tosi G. 4 , Costantino L. 4 , Rivasi F. 2 , Bertolini A. 1 , Ruozzi B. 4 ,<br />
Forni F. 4 , Vandelli M.A. 4<br />
1 Struttura Complessa <strong>di</strong> Tossicologia e Farmacologia Clinica; 2 Sezione <strong>di</strong> Anatomia Patologica;<br />
3 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia;<br />
4 Dipartimento <strong>di</strong> Scienze<br />
Farmaceutiche, Università <strong>di</strong> Modena e Reggio Emilia<br />
Nanoparticelle polimeriche coniugate con un glico-eptapeptide come trasportatori <strong>di</strong> farmaci<br />
all'interno del sistema nervoso centrale.<br />
Solinas Marcello 1,2 , Scherma M. 2,3 , Fattore L. 4 , Stroik J. 2 , Wertheim C.E. 2 , Tanda G. 2 , Fratta<br />
W. 3 , Goldberg S.R. 2<br />
1 IBPC, CNRS-6187, University of Poitiers, France; 2 NIDA, NIH, DHHS, USA; 4 Dipartimento <strong>di</strong><br />
Neuroscienze, Università of Cagliari; 5 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong> Cagliari<br />
I recettori nicotinici come nuovi targets per il trattamento dell’abuso <strong>di</strong> cannabis.<br />
Pistis Marco 1 , Pillolla G. 1 , Perra S.Z., Melis M. 1 , Muntoni A.L. 2<br />
1 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari; 2 Istituto <strong>di</strong> Neuroscienze CNR, Sezione <strong>di</strong><br />
Cagliari<br />
La stimolazione del me<strong>di</strong>al forebrain bundle induce mo<strong>di</strong>ficazioni a breve e a lungo termine<br />
nell’attività dei neuroni dopaminergici: coinvolgimento dei recettori cannabinoide e glutamatergico.<br />
Viganò Daniela G., Guidali C., Rubino T., Parolaro D.<br />
DBSF, Università dell’Insubria (VA)<br />
Ruolo del sistema recettoriale cannabico in un modello farmacologico <strong>di</strong> schizofrenia.<br />
Trezza Viviana 1 , Cuomo V. 2 , Vanderschuren L.J.M.J. 1<br />
1 Dept. Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Me<strong>di</strong>cal<br />
Center Utrecht, Utrecht, The Netherlands; 2 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia,<br />
Università <strong>di</strong> Roma “La Sapienza”<br />
Farmaci attivi sul sistema cannabinoide: effetti prosociali e antisociali in ratti Wistar adolescenti.<br />
31<br />
Castaldo Pasqualina 1 , Magi S. 1 , Gaetani S. 2 , Cassano T. 3 , Ferraro L. 4 , Corcione E. 1 , Antonelli<br />
T. 4 , Cuomo V. 2 , Amoroso S. 1<br />
1 Sezione <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Neuroscienze, Università “Politecnica delle Marche”,<br />
Ancona; 2 Dipartimento <strong>di</strong> Farmacologia e Fisiologia umana Università <strong>di</strong> Roma “La Sapienza”;<br />
3 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che Università <strong>di</strong> Foggia; 4 Sezione <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong><br />
Me<strong>di</strong>cina Clinica e Sperimentale, Università <strong>di</strong> Ferrara<br />
L’esposizione prenatale all’agonista del recettore per i cannabinoi<strong>di</strong> WIN 55,212-2 riduce l’efflusso ed<br />
aumenta la ricaptazione <strong>di</strong> glutammato attraverso una sovraespressione dei trasportatori del<br />
glutammato glt1 ed eaac1 nella corteccia prefrontale <strong>di</strong> ratto.<br />
pag_dx.indd 1 30/05/2007 0.56.43
Simposio<br />
Asma e patologie correlate<br />
Moderatori: Rossi F (Napoli) Cirino G (Napoli)<br />
Sessione ECM<br />
08.30/08.50 Fabbri LM (Modena)<br />
Asma e BPCO: storia naturale <strong>di</strong> asma e BPCO (implicazioni terapeutiche)<br />
08.50/09.10 Brusasco V (Genova)<br />
Asma e rinite: due fenotipi dell'allergopatia respiratoria<br />
09.10/09.30 Di Maria G (Catania)<br />
Asma e apnea notturna: strategie per migliorare la vita dei pazienti<br />
09.30/09.50 Scaglione F (Milano)<br />
Asma e infezioni: relativi trattamenti appropriati<br />
09.50/10.10 Polverino M (Salerno)<br />
Asma e obesità: BMI e asma<br />
10.10/10.30 D'Agostino B (Napoli)<br />
Asma e reflusso gastroesofageo: ruolo delle fibre C (modelli animali)<br />
10.30/11.00 Discussione<br />
SALA 6<br />
08.30-11.00<br />
32<br />
Realizzato con il contributo educazionale <strong>di</strong> AstraZeneca<br />
Sessione ECM<br />
Simposio<br />
Modulazione farmacologica dell'infiammazione polmonare nella<br />
broncopneumopatia cronica ostruttiva<br />
Moderatori: Barnes PJ (Londra) Montuschi P (Roma)<br />
08.30/08.55 Folco G (Milano)<br />
Basi fisiopatologiche della broncopneumopatia cronica ostruttiva<br />
08.55/09.20 Geppetti P (Firenze)<br />
Canali TPR e patologia respiratoria<br />
09.20/09.45 Fabbri L (Modena)<br />
La terapia farmacologica della broncopneumopatia cronica ostruttiva<br />
SALA 7<br />
08.30-11.00<br />
09.45/10.10 Barnes PJ (Londra)<br />
Nuove strategie farmacoterapeutiche per la broncopneumopatia cronica ostruttiva<br />
10.10/10.35 Montuschi P (Roma)<br />
Meto<strong>di</strong>che non invasive nel monitoraggio dell'infiammazione polmonare e della terapia<br />
farmacologica nella broncopneumopatia cronica ostruttiva<br />
10.35/11.00 Discussione<br />
Realizzato con il contributo educazionale <strong>di</strong> Altana<br />
pag_sx.indd 1 30/05/2007 0.58.37
Sessione ECM<br />
Simposio<br />
Key research strategies in pharmacology: how to take water into<br />
dry pipe-lines<br />
(<strong>SIF</strong> - EPHAR)<br />
Moderatori: Weston A (Manchester) Drago F (Catania)<br />
08.30/08.55 Brunello N (Milano)<br />
Are anti-inflammatory drugs the antidepressants of the future?<br />
SALA 8<br />
08.30-11.00<br />
08.55/09.20 Edwards G (Manchester)<br />
Ca 2+ -sensing receptors in blood vessels: potential new targets in vascular <strong>di</strong>sease<br />
09.20/09.45 Buckingham J (Londra)<br />
Glucocorticoids: exemplars of multi-tasking<br />
09.45/10.10 Smits J (Maastricht)<br />
Molecular imaging of ischemic heart <strong>di</strong>sease: new pharmacological targets<br />
10.10/10.35 Sebastiao A (Lisbona)<br />
Adenosine receptors in neuroprotection<br />
10.35/11.00 Discussione<br />
Pausa caffè<br />
11.00-11.30<br />
33<br />
Lettura Plenaria<br />
Moderatore: Fratta W (Cagliari)<br />
Santarelli L (Palo Alto, USA)<br />
Ruolo funzionale della neurogenesi nell’adulto<br />
AUDITORIUM<br />
11.30-12.30<br />
Sessione Poster<br />
12.30-15.00<br />
Colazione <strong>di</strong> lavoro<br />
12.30-13.30<br />
Incontro con l’Esperto<br />
Moderatore: Fratta W (Cagliari)<br />
Grassi MC (Roma)<br />
La Vareniclina: nuove prospettive nella terapia del tabagismo<br />
Realizzato con il contributo educazionale <strong>di</strong> Pfizer<br />
SALA 4<br />
14.00-15.00<br />
pag_dx.indd 1 30/05/2007 1.09.57
Incontro con l'Esperto<br />
Moderatore: Scaglione F (Milano)<br />
Mazzei T (Firenze)<br />
Ricerca e sviluppo in antibioticoterapia: a che punto siamo?<br />
SALA 5<br />
14.00-15.00<br />
34<br />
Sessione ECM<br />
Simposio<br />
Nuove acquisizioni nella ricerca sui cannabinoi<strong>di</strong><br />
Moderatori: Fratta W (Cagliari) Parolaro D (Varese)<br />
15.00/15.20 Piomelli D (Irvine)<br />
Il sistema endocannabinoide alla soglia della terapia<br />
AUDITORIUM<br />
15.00-17.30<br />
15.20/15.40 Le Fur G (Parigi)<br />
Il ruolo del Rimonabant, un antagonista dei recettori CB 1 , nel trattamento dell'obesità<br />
e dei fattori <strong>di</strong> rischio car<strong>di</strong>ometabolici associati<br />
15.40/16.00 Di Marzo V (Napoli)<br />
Il sistema endocannabinoide nelle malattie neurodegenerative e nel dolore<br />
neuropatico<br />
16.00/16.20 Cuomo V (Roma)<br />
Un'alterata neurogenesi dei neuroni ippocampali è associata a deficit funzionali<br />
osservati nei ratti adulti esposti nel periodo prenatale ai cannabinoi<strong>di</strong><br />
16.20/16.40 Parolaro D (Varese)<br />
Il trattamento cronico con THC durante il periodo adolescenziale induce mo<strong>di</strong>ficazioni<br />
neurobiologiche <strong>di</strong> lunga durata nell'adulto<br />
16.40/17.00 Fratta W (Cagliari)<br />
Possibile ruolo del sistema endocannabinoide nelle reci<strong>di</strong>ve all'abuso <strong>di</strong> sostanze<br />
17.00/17.30 Discussione<br />
Realizzato con il contributo educazionale <strong>di</strong> Sanofi Aventis Recherce & Dev.<br />
pag_sx.indd 1 30/05/2007 1.12.14
Cre<strong>di</strong>ti ECM assegnati 4<br />
Simposio<br />
Modulazione farmacologica dei recettori P 2<br />
(<strong>SIF</strong> - Gruppo Nazionale Adenosina)<br />
Moderatori: Abbracchio MP (Milano) Pedata F (Firenze)<br />
15.00/15.15 Volpini R (Trieste)<br />
Progettazione e sintesi <strong>di</strong> nuovi ligan<strong>di</strong> dei recettori P 2<br />
SALA 1<br />
15.00-17.30<br />
15.15/15.30 Ferrari D (Ferrara)<br />
L'antibiotico polymyxina B è un potente modulatore allosterico del recettore P 2X7<br />
15.30/15.45 Verderio C (Milano)<br />
Ruolo del recettore P 2X7 nella funzione microgliale<br />
15.45/16.00 Volontè C (Roma)<br />
Recettori purinergici P 2 : nuove tendenze nel sistema nervoso centrale<br />
16.00/16.15 Ceruti S (Milano)<br />
ATP come molecola <strong>di</strong> segnalazione nel dolore trigeminale<br />
16.15/16.30 Pugliese AM (Firenze)<br />
Ruolo <strong>di</strong> ATP e dei recettori P 2 purinergici nella trasmissione sinaptica della regione<br />
CA1 <strong>di</strong> ippocampo <strong>di</strong> ratto sia in con<strong>di</strong>zioni normossiche che durante deprivazione <strong>di</strong><br />
ossigeno e glucosio<br />
16.30/16.45 Trincavelli ML (Pisa)<br />
Localizzazione dei recettori A1 e P 2Y1 nell'ippocampo e loro interazione funzionale<br />
16.45/17.00 Ballerini P (Chieti)<br />
Ruolo delle proteine ABC nella produzione me<strong>di</strong>ata dalle purine <strong>di</strong> fattori coinvolti<br />
nella fisiopatologia dell'aterosclerosi<br />
17.00/17.30 Questionario ECM<br />
35<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Giovani Farmacologi<br />
SALA 2<br />
15.00-20.00<br />
Moderatori: Concas A (Cagliari) Brunelleschi S (Novara) De Sarro A (Messina)<br />
Gunella Gabriele, Bardelli C., Amoruso A., Fresu L.G., Zeppegno P., Brunelleschi S.<br />
Dipartimento Scienze Me<strong>di</strong>che, Università del Piemonte Orientale “A.Avogadro”, Novara<br />
Sostanza P e Depressione: espressione del recettore NK1, attivazione <strong>di</strong> NF-B e rilascio <strong>di</strong> citochine<br />
in monociti <strong>di</strong> pazienti psichiatrici.<br />
Soldovieri Virginia 1 , Cilio M.R. 2 , Miceli F. 1 , Bellini G. 3 , Castaldo P. 1 , Shapiro M.S. 4 , Pascotto<br />
A. 3 , Annunziato L. 1 , Taglialatela M. 1,5<br />
1 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Napoli “Federico II”; 2 Dipartimento <strong>di</strong> Neurologia<br />
Infantile, Ospedale Pe<strong>di</strong>atrico “Bambin Gesù” <strong>di</strong> Roma; 3 Cattedra <strong>di</strong> Neuropsichiatria Infantile,<br />
Seconda Università <strong>di</strong> Napoli; 4 Dipartimento <strong>di</strong> Fisiologia, Centro <strong>di</strong> Scienze del Benessere,<br />
Università del Texas, San Antonio, USA; 5 Università del Molise, Campobasso<br />
Nuove mutazioni responsabili <strong>di</strong> convulsioni benigne familiari neonatali alterano aminoaci<strong>di</strong> non<br />
carichi del segmento S4 delle subunità dei canali del potassio KCNQ2 e riducono la funzionalità della<br />
corrente Ikm me<strong>di</strong>ante alterazioni delle proprietà <strong>di</strong> apertura.<br />
pag_dx.indd 1 30/05/2007 1.15.35
DiPalma Antonella, Desaphy J-F., Conte Camerino D.<br />
Dipartimento Farmaco-Biologico, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Bari<br />
L’orfenadrina blocca i canali al so<strong>di</strong>o voltaggio-<strong>di</strong>pendenti attraverso il legame al recettore <strong>degli</strong><br />
anestetici locali.<br />
Lintas Alessandra, Panin F., Diana M.<br />
“G. Minar<strong>di</strong>” Laboratory of Cognitive Neuroscience, Dipartimento <strong>di</strong> Scienze del Farmaco, Università<br />
<strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Sassari<br />
L’aumentata eccitabilità dei MSN del Nucleus Accumbens nell’astinenza da morfina.<br />
Pisu Maria Giuseppina 1 , Dore R. 3 , Biggio G. 1,2,3 , Serra M. 1,2,3<br />
1 CNR Istituto <strong>di</strong> Neuroscienze, Sezione <strong>di</strong> Cagliari; 2 Centro <strong>di</strong> Eccellenza per la Neurobiologia delle<br />
Dipendenze, 3 Dipartimento <strong>di</strong> Biologia Sperimentale, Sezione <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari<br />
Effetto dell’etanolo nei ratti socialmente isolati: <strong>di</strong>fferenze <strong>di</strong> genere.<br />
Coluccia Addolorata, Belfiore D., Borracci P., Renna G., Giustino A., Carratù M.R.<br />
Dipartimento <strong>di</strong> Farmacologia e Fisiologia Umana, Università <strong>di</strong> Bari<br />
Esposizione ad acido retinoico durante la gravidanza: alterazioni neurofunzionali nella progenie<br />
maschile e femminile <strong>di</strong> ratto.<br />
36<br />
Grilli Massimo 1 , Patti L. 1 , Robino F. 1 , Zappettini S. 1 , Sofianos I. 1 , Raiteri M. 1,2 , Marchi M. 1,2<br />
1 Sezione <strong>di</strong> Farmacologia e Tossicologia, Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Università <strong>di</strong><br />
Genova; 2 Centro <strong>di</strong> Eccellenza per la Ricerca Biome<strong>di</strong>ca, Università <strong>di</strong> Genova<br />
Coesistenza e interazione funzionale tra recettori presinaptici nicotinici e muscarinici che modulano il<br />
rilascio <strong>di</strong> neurotrasmettitori da sinaptosomi striatali.<br />
Carta Mario, Murru L., Barabino E., Botta P., Talani G., Zaccheddu R., Sanna E.,<br />
Biggio G.<br />
Dip. Di Biologia Sperimentale, Sezione Neuroscienze e Centro <strong>di</strong> Eccellenza per la Neurobiologia delle<br />
Dipendenze, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Cagliari<br />
Uso dell’isoniazide, un inibitore dell'acido glutammico decarbossilasi, per lo stu<strong>di</strong>o in vitro del ruolo<br />
della trasmissione GABAergica nel controllo del circuito neuronale della corteccia cerebellare<br />
Leggio Gian Marco, Consoli D., Mazzola C., Micale V., Drago F.<br />
Dipartimento <strong>di</strong> Farmacologia Sperimentale e Clinica, Università <strong>di</strong> Catania<br />
Effetti comportamentali dell’agonista del recettore 3 adrenocettore sr58611a: prototipo <strong>di</strong> una<br />
nuova classe <strong>di</strong> farmaci antidepressivi/ansiolitici?<br />
Rocchitta Gaia 1 , Puggioni G. 1 , Dedola S. 1 , Bazzu G. 1 , Lowry J.P. 2 , O’Neill R.D. 3 , Serra P.A. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Sassari; 2 Department of Chemistry, National University o<br />
Ireland, Maynooth, Co. Kildare, Ireland; 3 UCD School of Chemistry and Chemical Biology, University<br />
College Dublin, Belfield, Dublin 4, Ireland.<br />
Sviluppo <strong>di</strong> un nuovo sistema biotelemetrico per il monitoraggio in tempo reale <strong>di</strong> nitrossido,<br />
glutammato e acido ascorbico nello striato <strong>di</strong> ratti freely moving.<br />
17.15 – 17.30 INTERVALLO<br />
pag_sx.indd 1 30/05/2007 1.18.57
Moderatori: Taglialatela M (Campobasso) Amoroso S (Ancona) Guarini S (Modena)<br />
Simioni Carolina 1 , Merighi S. 1 , Benini A. 1 , Mirandola P. 2 , Gessi S. 1 , Varani K. 1 , Leung E. 3 ,<br />
Maclennan S. 3 , Baral<strong>di</strong> P.G. 4 , Borea P.A. 1<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale Sez. Farmacologia, Università <strong>di</strong> Ferrara; 2 Dip. Di<br />
Anatomia Umana, Farmacologia e Me<strong>di</strong>cina Forense, Ist. Di Anatomia Umana, Osp. Maggiore,<br />
Università <strong>di</strong> Parma; 3 King Pharm. Res. and Dev., Inc., Cary, North Carolina, 4 Dipartimento <strong>di</strong><br />
Scienze Farmaceutiche, Università <strong>di</strong> Ferrara.<br />
L’ipossia inibisce l’apoptosi indotta da paclitaxel me<strong>di</strong>ante la fosforilazione <strong>di</strong> BAD <strong>di</strong>pendente<br />
dall’adenosina nelle cellule <strong>di</strong> glioblastoma.<br />
Poma Paola, Labbozzetta M., Notarbartolo M.,Maurici A., Rizzi M. * , Simoni D. * ,D’Alessandro<br />
N.<br />
Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Palermo e *Dipartimento <strong>di</strong> Scienze<br />
Farmaceutiche, Università <strong>di</strong> Ferrara<br />
Le attività antitumorali della curcumina e del suo nuovo analogo isossazolico MR 39 non vengono<br />
ostacolate dalla con<strong>di</strong>zione <strong>di</strong> multifarmacoresistenza <strong>di</strong> cellule tumorali che esprimono sia la P-<br />
glicoproteina che <strong>di</strong>fferenti IAP.<br />
Menna Pierantonio, Salvatorelli E., Minotti G.<br />
Dipartimento Scienze del Farmaco - Centro Scienze dell’ Invecchiamento, Università “G.d’Annunzio”,<br />
Chieti<br />
Distribuzione, metabolismo e tossicità della doxorubicina in car<strong>di</strong>omiociti: Ruolo della mioglobina.<br />
Salvatorelli Emanuela, Menna P., Minotti G.<br />
Dipartimento Scienze del Farmaco - Centro Scienze dell’ Invecchiamento, Università “G.d’Annunzio”,<br />
Chieti<br />
Sviluppo <strong>di</strong> un modello traslazionale <strong>di</strong> cuore umano per lo stu<strong>di</strong>o <strong>di</strong> interazioni tossico-metaboliche<br />
tra doxorubicina o epirubicina e paclitaxel o docetaxel.<br />
37<br />
Tramentozzi Elisa 1 , Pagetta A. 1 , Monopoli M. 1 , Frasson M. 2 , Finotti P. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia e Anestesiologia, Università <strong>di</strong> Padova; 2 Dipartimento <strong>di</strong> Biochimica,<br />
Università <strong>di</strong> Padova<br />
Angiogenesi indotta dalla “heat shock protein” Glucose-regulated protein 94 (GRP94) con<br />
meccanismo simile a quello <strong>di</strong> una citochina.<br />
Rodolico Gabriella, Piegari E., Vitelli M.R., Damiano V., Rossi F., Berrino L.<br />
Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Sezione <strong>di</strong> Farmacologia “L. Donatelli”, Centro <strong>di</strong> Eccellenza<br />
delle Malattie Car<strong>di</strong>ovascolari, Seconda Università <strong>di</strong> Napoli<br />
Variazione dell’espressione genica in cuori isolati <strong>di</strong> ratto <strong>di</strong>abetico e non perfusi con una soluzione<br />
ad alta concentrazione <strong>di</strong> glucosio.<br />
Conti Valeria 1 , Corbi G. 2 , Boccuti S. 3 , Ferrara N. 2 , Carusio N. 3 , Rinal<strong>di</strong> B. 3 , Rossi F. 3 ,<br />
Filippelli A. 3<br />
1 Scuola <strong>di</strong> Specializzazione in Farmacologia, Seconda Università <strong>di</strong> Napoli; 2 Dipartimento <strong>di</strong> Scienze<br />
della Salute, Università del Molise e Fondazione S. Maugeri, Istituto Scientifico <strong>di</strong> Telese Terme;<br />
3 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale e Centro <strong>di</strong> Eccellenza delle Malattie Car<strong>di</strong>ovascolari,<br />
Seconda Università <strong>di</strong> Napoli<br />
L’esercizio fisico prolungato e moderato in ratti anziani potenzia l’attività della sirtuina 1.<br />
Amoruso Angela 1 , Bardelli C. 1 , Ribichini F. 2 , Ferrero V. 2 , Vassanelli C. 2 , Brunelleschi S. 1<br />
1 Dipartimento <strong>di</strong> Scienze Me<strong>di</strong>che, Università Piemonte Orientale, Novara; 2 Divisione <strong>di</strong> Car<strong>di</strong>ologia,<br />
Università <strong>di</strong> Verona<br />
Differenze <strong>di</strong> genere nell’espressione <strong>di</strong> PPAR-gamma in pazienti affetti da coronaropatie.<br />
pag_dx.indd 1 30/05/2007 1.20.32
Esposito Emanuela 1,3 , Mazzon E. 2,3 , Muià C. 2 , Meli R. 1 , Bramanti P. 3 , Caputi A.P. 2,3 ,<br />
Cuzzocrea S. 2,3<br />
1 Dipartmento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”; 2 Dipartimento <strong>di</strong><br />
Me<strong>di</strong>cina Sperimentale e Clinica e Farmacologia, Università <strong>di</strong> Messina; 3 IRCCS Centro Neurolesi<br />
"Bonino-Pulejo", Messina<br />
L’inibizione genetica e farmacologica del TNF- riduce il danno da ischemia e riperfusione splancnica.<br />
38<br />
Cre<strong>di</strong>ti ECM assegnati 2<br />
Simposio<br />
Nuove prospettive terapeutiche nel trattamento della<br />
depressione. L'approccio melatoninergico: dalla farmacologia<br />
all'evidenza clinica<br />
Moderatori: Biggio G (Cagliari) Lorettu L (Sassari)<br />
15.00/15.10 Carpiniello B (Cagliari)<br />
Introduzione<br />
SALA 3<br />
15.00-17.30<br />
15.10/15.40 Aguglia E (Trieste)<br />
Il trattamento della depressione oggi: realtà clinica nell'uso <strong>degli</strong> antidepressivi<br />
15.40/16.10 Racagni G (Milano)<br />
Un nuovo step nella ricerca farmacologica: l'approccio melatoninergico<br />
16.10/16.40 Monteleone P (Napoli)<br />
Depressione e ritmi circa<strong>di</strong>ani: razionale per l'impiego <strong>di</strong> un antidepressivo<br />
melatoninergico<br />
16.40/17.10 Altamura AC (Milano)<br />
Depressione Maggiore: efficacia clinica e tollerabilità <strong>di</strong> un nuovo antidepressivo<br />
melatoninergico<br />
17.10/17.30 Biggio G (Cagliari)<br />
Conclusione e Questionario ECM<br />
Simposio<br />
Infiammazioni e sindromi coronariche acute: stato dell'arte<br />
SALA 4<br />
15.00-17.30<br />
Moderatori: Rossi F (Napoli) Golino P (Napoli)<br />
15.00/15.30 Biasucci L (Roma)<br />
L'attivazione del sistema immunitario nella placca è conseguenza <strong>di</strong> un evento<br />
infiammatorio sistemico<br />
15.30/16.00 De Palma R (Napoli)<br />
L'attivazione del sistema immunitario nella placca è conseguenza <strong>di</strong> un evento<br />
infiammatorio locale<br />
16.00/16.30 Berrino L (Napoli)<br />
Differenti patterns <strong>di</strong> espressione genica nelle placche instabili<br />
16.30/17.00 Tremoli E (Milano)<br />
Markers <strong>di</strong> attivazione piastrinica nella placca aterosclerotica<br />
17.00/17.30 Cattaneo M (Milano)<br />
Clopidogrel e sindromi coronariche acute: cosa c'è oltre l'effetto antiaggregante?<br />
pag_sx.indd 1 30/05/2007 7.07.50
Tavola Rotonda<br />
Farmacologia <strong>di</strong> genere: dal laboratorio alla società<br />
SALA 5<br />
15.00-17.30<br />
Moderatori: Franconi F (Sassari) Caporale C (Roma) Schirru A (Cagliari)<br />
15.00/15.10 Franconi F (Sassari) Caporale C (Roma)<br />
Presentazione della tavola rotonda<br />
15.10/15.40 Bellantuono C (Verona)<br />
Antidepressivi e rischio <strong>di</strong> malformazioni maggiori<br />
15.40/15.50 Marilotti L (Cagliari)<br />
Il <strong>di</strong>ritto alla salute<br />
15.50/16.10 Vella S (Roma)<br />
La farmacologia <strong>di</strong> genere nella ricerca pubblica ed in clinica<br />
16.10/16.30 Mazzaglia G (Firenze)<br />
Potenzialità della ricerca epidemiologica sui flussi correnti nella specificità <strong>di</strong> genere<br />
16.30/16.45 Cricelli C (Firenze)<br />
La farmacologia <strong>di</strong> genere e la me<strong>di</strong>cina <strong>di</strong> base<br />
16.45/17.05 Ruffilli MP (Roma)<br />
La farmacologia <strong>di</strong> genere e la ricerca industriale<br />
17.05/17.25 Linguiti D (Roma)<br />
La politica delle pari opportunità e la salute delle donne<br />
17.25/17.30 Franconi F (Sassari)<br />
Conclusioni<br />
39<br />
Simposio<br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> sicurezza dei me<strong>di</strong>cinali biologici (anticorpi monoclonali)<br />
(<strong>SIF</strong> - SITOX)<br />
SALA 6<br />
15.00-17.30<br />
Moderatori: Cantelli Forti G (Bologna) Riccar<strong>di</strong> C (Perugia)<br />
15.00/15.30 Ascione A (Roma)<br />
Biotecnologie immunologiche e loro applicazione<br />
15.30/16.00 Dempster A (Cambridge, USA)<br />
Non clinical safety evaluation of biotechnologically derived pharmaceuticals<br />
16.00/16.30 Bernar<strong>di</strong> C (Milano)<br />
I primati non umani nella ricerca dei me<strong>di</strong>cinali biologici<br />
16.30/17.00 Meneguz A (Roma)<br />
Le prospettive regolatorie dopo il caso TGN 1412<br />
17.00/17.30 Rossi P (Roma)<br />
Il nostro fantastico sistema immunitario<br />
pag_dx.indd 1 30/05/2007 1.25.58
Simposio<br />
La formazione specialistica in Farmacologia<br />
SALA 7<br />
15.00-17.30<br />
40<br />
Moderatore: Chiesara E (Milano) Caputi AP (Messina)<br />
15.00/15.15 Chiesara E (Milano)<br />
Presentazione del problema<br />
15.15/15.30 Frigo G (Pavia)<br />
Stato dell'arte<br />
15.30/15.45 Patrono C (Roma)<br />
Sperimentazione Clinica-Farmacologica in Italia<br />
15.45/16.00 Furlanut M (U<strong>di</strong>ne)<br />
Esperienze regionali<br />
16.00/16.15 Ad<strong>di</strong>s A (Roma)<br />
La formazione a <strong>di</strong>stanza (FAD) promossa dall'AIFA<br />
16.15/16.30 Cricelli C (Firenze)<br />
Il punto <strong>di</strong> vista della SIMG<br />
16.30/16.45 Del Tacca M (Pisa)<br />
Sbocchi professionali<br />
16.45/17.00 Cella S (Milano)<br />
Interventi preor<strong>di</strong>nati: esperienze ospedaliere<br />
17.00/17.20 Discussione<br />
17.20/17.30 Caputi AP (Messina)<br />
Conclusioni<br />
Sessione ECM<br />
Simposio<br />
Farmacoutilizzazione e appropriatezza d'uso dei farmaci<br />
Moderatori: Giusti P (Padova) Corrao G (Milano)<br />
15.00/15.20 Lucioni C (Milano)<br />
Consumo <strong>di</strong> farmaci: dosaggi empirici verso appropriatezza terapeutica<br />
15.20/15.40 Haycox A (Liverpool)<br />
Utilizzo <strong>di</strong> data base nelle realtà europee<br />
SALA 8<br />
15.00-17.30<br />
15.40/16.00 Zambon A (Milano)<br />
Fattori pre<strong>di</strong>ttori <strong>di</strong> <strong>di</strong>scontinuità e <strong>di</strong> fallimento della terapia con bisfosfonati:<br />
risultati da uno stu<strong>di</strong>o <strong>di</strong> coorte basato su <strong>di</strong> un'ampia popolazione<br />
16.00/16.20 Mazzaglia G (Firenze)<br />
Analisi della relazione tra l'aderenza alla terapia con antiipertensivi e l'insorgenza <strong>di</strong><br />
eventi car<strong>di</strong>ovascolari non fatali in comunità<br />
16.20/16.40 Chiroli S (Milano)<br />
Valutazione dell'efficacia comparativa nell'Unione Europea: dati e metodologia<br />
16.40/17.00 Chinellato A (Treviso)<br />
Epidemiologia e trattamento del dolore da cancro: stiamo uccidendo la morfina?<br />
17.00/17.30 Discussione<br />
Realizzato con il contributo educazionale <strong>di</strong> AstraZeneca, Amgen, Abbott<br />
pag_sx.indd 1 04/06/2007 11.42.57
Simposio<br />
Nuovi aspetti patogenetici e terapeutici della<br />
neurodegenerazione<br />
(<strong>SIF</strong> - ITINAD)<br />
Moderatori: Canonico PL (Novara) Caltagirone CF (Roma)<br />
Sessione ECM<br />
17.30/17.55 Copani AG (Catania)<br />
Il ruolo del ciclo cellulare nella malattia <strong>di</strong> Alzheimer: implicazioni per la<br />
neuroprotezione<br />
17.55/18.20 Di Luca M (Milano)<br />
Meccanismi molecolari <strong>di</strong> malattie neurodegenerative<br />
18.20/18.45 Borroni B (Verona)<br />
Modelli periferici e terapia<br />
AUDITORIUM<br />
17.30-19.30<br />
18.45/19.10 Ghiglieri V (Roma)<br />
Modelli sperimentali <strong>di</strong> malattia <strong>di</strong> Parkinson: un approccio comportamentale ed<br />
elettrofisiologico<br />
19.10/19.30 Memo M (Brescia)<br />
Attività cellulari della proteina beta amiloide<br />
Realizzato con il contributo educazionale <strong>di</strong> Bracco<br />
41<br />
Sessione ECM<br />
Simposio<br />
La neurobiologia ed i trattamenti farmacologici del poliabuso<br />
Moderatori: Nava F (Padova) Tagliamonte A (Siena)<br />
17.30/17.50 Tagliamonte A (Siena)<br />
Introduzione al fenomeno del poliabuso<br />
17.50/18.10 Nava F (Padova)<br />
Le basi neurobiologiche della clinica del poliabuso<br />
18.10/18.30 Ciccocioppo R (Camerino)<br />
La ricerca traslazionale nella polydrug ad<strong>di</strong>ction: il ruolo del recettore della<br />
nocicettina<br />
18.30/18.50 Diana M (Iglesias)<br />
Il ruolo del poliabuso nel paziente con doppia <strong>di</strong>agnosi<br />
18.50/19.30 Discussione<br />
SALA 1<br />
17.30-19.30<br />
Realizzato con il contributo educazionale <strong>di</strong> Laboratori Farm. CT<br />
pag_dx.indd 1 30/05/2007 1.29.27
Sessione ECM<br />
Simposio<br />
Farmaci inibitori della pompa protonica e danno <strong>di</strong>gestivo indotto<br />
da FANS: aspetti farmacologici e clinici<br />
Moderatori: Del Tacca M (Pisa) Tonini M (Pavia)<br />
17.30/17.55 Tonini M (Pavia)<br />
Meccanismi d'azione dei farmaci inibitori della pompa protonica<br />
SALA 3<br />
17.30-19.30<br />
17.55/18.20 Blan<strong>di</strong>zzi C (Pisa)<br />
Inibitori <strong>di</strong> pompa protonica e secrezione gastrica: determinanti farmaco<strong>di</strong>namici,<br />
farmacocinetici e farmacogenetici<br />
18.20/18.45 De Ponti F (Bologna)<br />
Effetti dei FANS sui meccanismi <strong>di</strong> protezione e riparazione della mucosa <strong>di</strong>gestiva:<br />
basi molecolari<br />
18.45/19.10 Scarpignato C (Parma)<br />
COXIB e apparato <strong>di</strong>gerente: una promessa mantenuta?<br />
19.10/19.30 Pilotto A (S. Giovanni Rotondo)<br />
Ruolo <strong>degli</strong> inibitori <strong>di</strong> pompa protonica nel trattamento <strong>degli</strong> effetti avversi <strong>di</strong>gestivi<br />
dei FANS<br />
42<br />
Realizzato con il contributo educazionale <strong>di</strong> AstraZeneca, Malesci<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Farmacologia del dolore e infiammazione<br />
SALA 4<br />
17.30-19.30<br />
Moderatori: Calignano A (Napoli) Maione S (Napoli)<br />
Colucci Mariantonella 1 , Maione F. 1,2 , Federica M. 3 , Di Giannuario A. 1 , Pieretti S. 1<br />
1 Istituto Superiore <strong>di</strong> Sanità, Dipartimento del Farmaco, Roma; 2 Dipartimento <strong>di</strong> Farmacologia<br />
Sperimentale, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Napoli “Federico II”, Napoli; 3 Dipartimento <strong>di</strong> Fisiologia e<br />
Farmacologia “Vittorio Erspamer” Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Roma “La Sapienza”, Roma<br />
Il ruolo del recettore dei pepti<strong>di</strong> formilati nel controllo della trasmissione nocicettiva: un contributo<br />
dai topi transgenici mancanti <strong>di</strong> tale recettore.<br />
Calignano Antonio, La Rana G., Russo R., Sasso O., D’Agostino G.<br />
Dip. Farmacologia Sperimentale, Facoltà <strong>di</strong> Farmacia, Napoli<br />
Gli agonisti PPAR- inducono analgesia attraverso l’attivazione dei canali del potassio ad ampia e<br />
me<strong>di</strong>a conduttanza.<br />
Lattanzi Roberta, Franchi S. 1 , Sacerdote P. 1 , Melchiorri P., Negri L.<br />
Dipartimento Fisiologia Umana e Farmacologia, Roma “La Sapienza”; 1 Dipartimento <strong>di</strong> Farmacologia,<br />
Milano<br />
Le prostaglan<strong>di</strong>ne contribuiscono alla sensitizzazione nocicettiva indotta da Bv8.<br />
pag_sx.indd 1 30/05/2007 1.31.40
Siniscalco Dario, Giordano C., Luongo L., de Novellis V., Rossi F., Di Marzo V. 1 , Maione S.<br />
1 Istituto <strong>di</strong> Chimica Biomolecolare, CNR Pozzuoli (NA); Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Sez.<br />
Farmacologia, Seconda Università <strong>di</strong> Napoli<br />
Espressione dei geni dell’Apoptosi in un modello murino <strong>di</strong> dolore neuropatico: ruolo del sistema<br />
endocannabinoide.<br />
Ghelar<strong>di</strong>ni Carla, Vivoli E., Norcini M., Bartolini A., Martinelli M. 1 , Petrillo P. 1 , Farina C. 1<br />
Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Firenze, Firenze; 1 NiKem Research Srl, Milano<br />
Effetti anti-iperalgesici del derivato pirroli<strong>di</strong>nonico nik-13317 in modelli <strong>di</strong> dolore neuropatico.<br />
Moderatori: Filippelli A (Napoli) Bernar<strong>di</strong>ni R (Catania)<br />
Viaro Riccardo 1 , Marti M. 1 , Morari M. 1 , Franchi G. 2<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Ferrara;<br />
2 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che e Terapie Avanzate, Sezione <strong>di</strong> Fisiologia Umana, Università <strong>di</strong><br />
Ferrara<br />
I recettori per la nocicettina/orfanina FQ localizzati nella sostanza nera reticolata modulano l’attività<br />
motoria e l’eccitabilità della corteccia motoria primaria nel ratto.<br />
Savani Clau<strong>di</strong>a 1,2 , De Filippis D. 3 , Scuderi C. 1,4 , Carnuccio R. 3 , De Stefano D. 3 , Iuvone T. 3 ,<br />
Esposito G. 1 , Steardo L. 1<br />
1 Dipartimento <strong>di</strong> Fisiologia umana e Farmacologia “Vittorio Erspamer”, Università “La Sapienza”,<br />
Roma; 2 Dipartimento <strong>di</strong> Fisiologia umana e Farmacologia, Università <strong>di</strong> Bari; 3 Dipartimento <strong>di</strong><br />
Farmacologia Sperimentale, Università <strong>di</strong> Napoli Federico II; 4 Dipartimento <strong>di</strong> Scienze<br />
Farmacologiche, Università <strong>di</strong> Palermo<br />
Proprietà antiinfiammatorie della PEA in cellule C6 stimolate con peptide beta amiloide.<br />
43<br />
Franchi Silvia, Panerai A., Negri L. 1 , Melchiorri P. 1 , Sacerdote P.<br />
Dipartimento <strong>di</strong> Farmacologia Chemioterapia e Tossicologia Me<strong>di</strong>ca, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano;<br />
1 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, Università La Sapienza, Roma<br />
Il sistema delle prokineticine/Bv8 come nuovo modulatore delle risposte immuni: rilevanza nelle<br />
malattie infiammatorie.<br />
Amantea Diana 1 , Gliozzi M. 2 , Corasaniti M.T. 2 , Bagetta G. 1<br />
1 Dipartimento Farmacobiologico, Università della Calabria, Rende (CS); 2 Dipartimento <strong>di</strong> Scienze<br />
Farmacobiolgiche, Università “Magna Graecia”, Catanzaro<br />
Le metalloproteinasi della matrice (MMPs) sono coinvolte nell’aumento precoce <strong>di</strong> interleuchina (IL-<br />
1) indotto da ischemia cerebrale focale transitoria nel ratto.<br />
Gianella Anita 1 , Nobili E. 1 , Gelosa P. 1 , Mussoni L. 1 , Bellosta S. 1 , Canadesi M. 1 , Abbate M. 2 ,<br />
Zoja C. 2 , Tremoli E. 1,3 , Sironi L. 1<br />
1 Dipartimento Scienze Farmacologiche, Università <strong>di</strong> Milano; 2 Centro Car<strong>di</strong>ologico Monzino IRCCS,<br />
Milano; 3 Ist. Mario Negri, Bergamo<br />
La rosuvastatina previene il danno renale spontaneo nei ratti SHRSP modulando il sistema<br />
plasminogeno/plasmina e l'espressione delle metalloproteasi.<br />
pag_dx.indd 1 30/05/2007 1.35.22
Simposio<br />
Targets cellulari e molecolari per lo sviluppo <strong>di</strong> nuove terapie in<br />
corso <strong>di</strong> neuroAIDS<br />
SALA 5<br />
17.30-19.30<br />
44<br />
Moderatori: Bagetta G (Cosenza) Pittaluga A (Genova)<br />
17.30/17.50 Pittaluga A (Genova)<br />
Interazione tra proteine del virus HIV-1 e recettori per il glutammato: loro ruolo in<br />
corso <strong>di</strong> neuroAIDS<br />
17.50/18.10 Viviani B (Milano)<br />
IL-1 beta e recettore NMDA: un pericoloso legame in corso <strong>di</strong> neuroAIDS<br />
18.10/18.30 Russo R (Cosenza)<br />
Definizione <strong>di</strong> un ruolo per la metalloproteasi della matrice (MMPs) nell'apoptosi<br />
neuronale indotta dalla gp120 del virus HIV-1 nel ratto<br />
Moderatori: Mollace V (Catanzaro) Marinovich M (Milano)<br />
18.30/18.50 Bezzi P (Losanna)<br />
Esocitosi Ca 2+ -regolata <strong>di</strong> glutammato da astrociti: un duplice ruolo nella<br />
comunicazione normale e patologica tra neuroni e glia<br />
18.50/19.10 Sgura A (Roma)<br />
Ruolo dello stress ossidativo nell'apoptosi me<strong>di</strong>ata dal virus HIV-1 e sulla lunghezza<br />
dei telomeri in una linea cellulare umana <strong>di</strong> astrocitoma<br />
19.10/19.30 Muscoli C (Cosenza)<br />
Modulazione farmacologica dello stress ossidativo nei <strong>di</strong>sor<strong>di</strong>ni neurodegenerativi da<br />
HIV<br />
Simposio<br />
Meccanismi farmacologici che regolano la proliferazione e il<br />
<strong>di</strong>fferenziamento delle cellule staminali<br />
SALA 6<br />
17.30-19.30<br />
Moderatori: Melchiorri D (Roma) Gorio A (Milano)<br />
17.30/17.50 Finocchiaro G (Milano)<br />
Cellule staminali da cancro<br />
17.50/18.10 Gorio A (Milano)<br />
Cellule staminali e lesioni midollari<br />
18.10/18.30 Reitano E (Milano)<br />
Terapia <strong>di</strong> sostituzione cellulare con cellule staminali<br />
18.30/18.50 Sartiani L (Firenze)<br />
Differenziamento car<strong>di</strong>omiocitario delle cellule staminali embrionali: proprietà<br />
funzionali e fattori <strong>di</strong> modulazione<br />
18.50/19.10 Melchiorri D (Roma)<br />
Ruolo dei recettori metabotropici del glutammato nel <strong>di</strong>fferenziamento delle cellule<br />
staminali<br />
19.10/19.30 Discussione<br />
pag_sx.indd 1 30/05/2007 1.39.57
Simposio<br />
Canali ionici come bersagli terapeutici per malattie genetiche e<br />
non-genetiche<br />
SALA 7<br />
17.30-19.30<br />
Moderatori: Conte Camerino D (Bari) Fontaine B (Parigi)<br />
17.30/17.50 Fontaine B (Parigi)<br />
Malattie dei canali del nervo e del muscolo<br />
17.50/18.10 Tricarico D (Bari)<br />
Coinvolgimento dei canali K + nelle patologie muscolari genetiche e non:<br />
dall'espressione genica alla terapia farmacologica<br />
18.10/18.30 Taglialatela M (Campobasso)<br />
Fisiopatologia e farmacologia molecolari dei canali KCNQ neuronali<br />
18.30/18.50 Sanna E (Cagliari)<br />
Recettori GABA A extrasinaptici: ruolo fisiologico, plasticità e nuove prospettive<br />
farmacologiche<br />
18.50/19.10 Evoli A (Roma)<br />
Canalopatie paraneoplastiche<br />
19.10/19.30 Cerbai E (Firenze)<br />
La corrente I f in cellule car<strong>di</strong>ache non-pacemaker: ruolo e implicazioni farmacologiche<br />
Sessione ECM<br />
Simposio<br />
La malattia <strong>di</strong> Parkinson: dalla biologia molecolare alla terapia<br />
(<strong>SIF</strong> - LIMPE)<br />
Moderatori: Corsini GU (Pisa) Ruggeri S (Roma)<br />
17.30/18.00 Morelli M (Cagliari)<br />
Fisiopatologia dei gangli della base<br />
18.00/18.30 Fornai F (Pisa)<br />
Nuovi aspetti patogenetici<br />
18.30/19.00 Maggio R (L’Aquila)<br />
Basi farmacologiche della terapia<br />
19.00/19.30 Bonucelli U (Pisa)<br />
Nuove terapie<br />
SALA 8<br />
17.30-19.30<br />
45<br />
pag_dx.indd 1 30/05/2007 1.41.07
Sessione ECM<br />
Simposio<br />
La cascata della via WNT come target delle patologie<br />
neurodegenerative<br />
Moderatori: Gaviraghi G (Siena) Pepeu G (Firenze)<br />
AUDITORIUM<br />
08.30-11.00<br />
08.30/08.55 Nicoletti F (Roma)<br />
L'induzione dell'antagonista della via <strong>di</strong> WNT, Dickkopf-1, come marker <strong>di</strong> morte<br />
neuronale eccitotossica<br />
08.55/09.20 Caricasole A (Siena)<br />
La via <strong>di</strong> WNT e la malattia <strong>di</strong> Alzheimer<br />
09.20/09.45 Casamenti F (Firenze)<br />
<strong>Stu<strong>di</strong></strong>o della cascata della via WNT in modelli animali <strong>di</strong> malattia <strong>di</strong> Alzheimer<br />
09.45/10.10 Hoozemanns J (Amsterdam)<br />
<strong>Stu<strong>di</strong></strong>o del pathway WNT in encefali postmortem in pazienti con malattia <strong>di</strong> Alzheimer<br />
10.10/11.00 Discussione<br />
46<br />
Tavola Rotonda<br />
La prima del farmaco sull'uomo<br />
Moderatori: Vella S (Roma) Velo GP (Verona)<br />
08.30/09.10 Breckenridge A (London)<br />
The day the sky fell in. TGN 1412 and what happened next<br />
09.10/09.30 Popoli P (Roma)<br />
"Piccoli" stu<strong>di</strong> crescono: la sperimentazione clinica <strong>di</strong> fase I in Italia<br />
09.30/09.55 Tomino C (Roma)<br />
La ricerca clinica: crocevia tra investimenti, costi ed opportunità <strong>di</strong> sviluppo<br />
09.55/10.20 Bonino F (Milano)<br />
Le strane coppie, i stu<strong>di</strong> investigator initiated and industry co-sponsored<br />
10.20/10.45 Ruffilli MP (Roma)<br />
La ricerca nell'uomo: un grande viaggio inizia dal primo passo<br />
10.45/11.00 Discussione<br />
SALA1<br />
08.30-11.00<br />
pag_sx.indd 1 30/05/2007 2.00.31
Sessione ECM<br />
Simposio<br />
Farmacologia dei recettori TRPV1 (vanilloi<strong>di</strong>) nel sistema nervoso<br />
centrale e periferico<br />
Moderatori: Di Marzo V (Napoli) Maione S (Napoli)<br />
SALA 2<br />
08.30-11.00<br />
08.30/08.50 Appen<strong>di</strong>no G (Novara)<br />
I composti naturali come prototipi per la scoperta <strong>di</strong> nuovi attivatori/inibitori <strong>di</strong> TRPV1<br />
e canali ionici correlati<br />
08.50/09.10 Geppetti P (Firenze)<br />
Sviluppo <strong>di</strong> potenti e selettivi ligan<strong>di</strong> del canale TRPV1 e loro potenzialità terapeutiche<br />
09.10/09.30 Di Marzo V (Napoli)<br />
Distribuzione, regolazione e ruolo fisiopatologico dei recettori TRPV1 nel cervello<br />
09.30/09.50 De Novellis V (Napoli)<br />
Gli endovanilloi<strong>di</strong> controllano l'attività del sistema <strong>di</strong>scendente inibitorio del dolore<br />
09.50/10.10 Wotjak CT (Monaco)<br />
Role of TRPV1 receptor in fear and anxiety<br />
10.10/11.00 Discussione<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Farmacologia car<strong>di</strong>ovascolare<br />
Moderatori: Cerbai E (Firenze) Desole MS (Sassari)<br />
SALA 3<br />
08.30-11.30<br />
Pierno Sabata 1 , Camerino G.M. 1 , Cippone V. 1 , Liantonio A. 1 , De Luca A. 1 , Kunic J. 2 , George<br />
A.L. Jr. 2 , Conte Camerino D. 1<br />
1 Sezione <strong>di</strong> Farmacologia, Dipartimento Farmaco-biologico, Università <strong>di</strong> Bari; 2 Dept. of Me<strong>di</strong>cine,<br />
Vanderbilt University, Nashville, TN, USA<br />
Meccanismi molecolari responsabili della mo<strong>di</strong>ficazione della conduttanza <strong>di</strong> membrana sostenuta dal<br />
canale al cloro clc-1 nel muscolo scheletrico <strong>di</strong> ratti trattati cronicamente con statine e fibrati.<br />
47<br />
Rinal<strong>di</strong> Barbara, Donniacuo M. 1 , Cappetta D. 1 , Capuano A. 1 , Romagnoli P. 2 , De Angelis A. 1 ,<br />
De Stefano D. 3 , Rossi F. 1 , Filippelli A. 1<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale e Centro <strong>di</strong> Eccellenza delle Malattie Car<strong>di</strong>ovascolari, Seconda<br />
Università <strong>di</strong> Napoli, Italia; 2 Dipartimento <strong>di</strong> Anatomia, Istologia e Me<strong>di</strong>cina Legale sez. E. Allara<br />
Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Firenze, Italia; 3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong><br />
Napoli Federico II Italia<br />
Il rosigliatazone riduce il processo infiammatorio indotto da un danno vascolare nel ratto.<br />
Di Francesco Luigia 1 , Piccoli A. 2 , Capone M. 1 , Evangelista V. 2 , Totani L. 2 , Patrignani P. 1<br />
1 Università G d’Annunzio, Chieti, Italy; 2 Mario Negri Sud, Santa Maria Imbaro Chieti<br />
Contributo delle isoforme della ciclo-ossogenasi alla produzione <strong>di</strong> prostaciclina e prostaglan<strong>di</strong>na E2<br />
da parte delle cellule endoteliali in risposta allo shear stress laminare.<br />
pag_dx.indd 1 30/05/2007 1.53.12
Benetti Elisa 1 , Collino M. 1 , Thiemermann C. 3 , Mastrocola R. 2 , Gallicchio M. 1 , Dianzani C. 1 ,<br />
Danni O. 2 , Aragno M. 2 , Fantozzi R. 1<br />
1 Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale. Università <strong>di</strong> <strong>Torino</strong>; 2 Dipartimento <strong>di</strong><br />
Me<strong>di</strong>cina Sperimentale e Oncologia, Università <strong>di</strong> <strong>Torino</strong>; 3 Centre for Exp Med, Nephrology & Critical<br />
Care, William Harvey Research Institute, London, UK<br />
L’inibitore selettivo della Glicogeno Sintasi Kinasi-3b, TDZD-8, riduce il danno indotto da una parziale<br />
ischemia-riperfusione cerebrale nell’ippocampo <strong>di</strong> ratto.<br />
Rossoni Giuseppe 1 , Sparatore A. 2 , Moore P.K. 3 , Manfre<strong>di</strong> B. 1 , Tazzari V. 4 , Del Soldato P. 4 ,<br />
Berti F. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia, Chemioterapia e Tossicologia Me<strong>di</strong>ca, Università <strong>di</strong> Milano, Italia;<br />
2 Istituto <strong>di</strong> Chimica Farmaceutica e Tossicologica "Pietro Pratesi", Università <strong>di</strong> Milano, Italia;<br />
3 Dipartimento <strong>di</strong> Farmacologia, Università Nazionale <strong>di</strong> Singapore, Singapore; 4 CTG Pharma, Milano,<br />
Italia<br />
Effetto car<strong>di</strong>oprotettivo del solfo-<strong>di</strong>clofenac nel cuore ischemico-reperfuso <strong>di</strong> coniglio.<br />
48<br />
Deambrosis Paola 1 , Saramin C. 1 , Terrazzani G. 1 , Bader G. 2 , Scaldaferri E. 3 , Chinellato A. 1 ,<br />
Giusti P. 4<br />
1 Servizio farmaceutico territoriale, Ulss9 Treviso; 2 Outcome research, Pfizer Roma; 3 I° Centro<br />
Anti<strong>di</strong>abetico, Me<strong>di</strong>cina I, Ulss9 Treviso; 4 Dipartimento <strong>di</strong> Farmacologia e Anestesiologia, Università <strong>di</strong><br />
Padova<br />
Effetti della terapia con statine sui livelli <strong>di</strong> colesterolo e sui ricoveri ospedalieri per patologie<br />
car<strong>di</strong>ovascolari, nell’ULSS <strong>di</strong> Treviso.<br />
Marasciulo Flora L, Potenza M.A., Tarquinio M., Quon M.J. 1 , Montagnani M.<br />
Dipartimento <strong>di</strong> Farmacologia e Fisiologia Umana, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Bari ; 1 Diabetes Unit,<br />
National Center for Complementary and Alternative Me<strong>di</strong>cine, National Institutes of Health, Bethesda,<br />
MD 20892, USA<br />
Meccanismi molecolari coinvolti negli effetti acuti e cronici dell’epigallocatechina gallato, un polifenolo<br />
del tè verde, sulla regolazione della funzione vascolare in ratti spontaneamente ipertesi (SHR).<br />
Chiesa Giulia, Parolini C., Marchesi M., Diani E., RIgamonti E., Cornelli L., Sirtori C.R.<br />
Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano<br />
Ridotta progressione <strong>di</strong> aterosclerosi in conigli alimentati con proteine <strong>di</strong> lupino.<br />
Vinci Maria Cristina, Bellik L., Parenti A., Ledda F.<br />
Laboratorio <strong>di</strong> Farmacologia Vascolare, Dipartimento <strong>di</strong> Farmacologia Clinica e Preclinica, Università <strong>di</strong><br />
Firenze<br />
Un biopolimero costituito da acido ialuronico (HYAFF-11) come supporto per la crescita <strong>di</strong> cellule<br />
progenitrici endoteliali umane.<br />
pag_sx.indd 1 30/05/2007 2.01.26
Sessione ECM<br />
Simposio<br />
Nocicettina/orfanina FQ: dagli stu<strong>di</strong> <strong>di</strong> base alla clinica<br />
Moderatori: Massi M (Camerino) Regoli D (Ferrara)<br />
08.30/08.50 Calò G (Ferrara)<br />
Il sistema nocicettina/orfanina FQ-recettore NOP e nuovi ligan<strong>di</strong> selettivi<br />
SALA 4<br />
08.30-11.00<br />
08.50/09.10 Ciccocioppo R (Camerino)<br />
Il sistema nocicettina/orfanina FQ come potenziale target per lo sviluppo <strong>di</strong> farmaci<br />
innovativi per la terapia dell'alcolismo<br />
09.10/09.30 Marti M (Ferrara)<br />
Il recettore della nocicettina/orfanina FQ come nuovo target per lo sviluppo <strong>di</strong> farmaci<br />
antiparkinsoniani<br />
09.30/09.50 Improta G (Roma)<br />
Ruolo del sistema nocicettina/orfanina FQ-recettore NOP nel controllo <strong>di</strong> attività<br />
secretorie e motorie gastrointestinali in con<strong>di</strong>zioni fisiologiche e patologiche<br />
09.50/10.10 D'Agostino B (Napoli)<br />
Ruolo della nocicettina e del suo recettore in un modello animale <strong>di</strong> infiammazione<br />
delle vie aeree<br />
10.10/10.30 Lazzeri M (Firenze)<br />
N-OFQ e recettore NOP: una nuova strategia nel trattamento dei <strong>di</strong>sturbi funzionali<br />
del basso tratto urinario<br />
10.30/11.00 Discussione<br />
49<br />
Sessione ECM<br />
Simposio<br />
Sistema nervoso - sistema immunitario tra interazione e<br />
integrazione: tempo per la neuro-immuno-farmacologia?<br />
(<strong>SIF</strong> - ISNIM)<br />
Moderatori: Cosentino M (Varese) Maestroni GJM (Locarno)<br />
SALA 5<br />
08.30-11.00<br />
08.30/08.50 Maestroni GJM (Locarno)<br />
Regolazione adrenergica <strong>di</strong>fferenziale della risposta immunitaria ai Pathogen<br />
Associated Molecular Patterns - Implicazioni nelle malattie infiammatorie e nei vaccini<br />
a base <strong>di</strong> cellule dendritiche<br />
08.50/09.10 Sacerdote P (Milano)<br />
La presenza <strong>di</strong> dolore modula la funzione immune e l’attivazione del sistema<br />
immunitario è coinvolta nella trasmissione nocicettiva<br />
09.10/09.30 Capellino SH (Regensburg)<br />
Meccanismi simpatoadrenergici nell'infiammazione sinoviale<br />
09.30/09.50 Marino F (Varese)<br />
Modulazione dopaminergica della funzionalità dei linfociti T regolatori: nuovi 'target'<br />
per la terapia farmacologica della sclerosi multipla?<br />
pag_dx.indd 1 30/05/2007 1.55.33
Comunicazioni<br />
Moderatori: Marino F (Varese) Lecchini S (Varese)<br />
D’Agostino Giuseppe 1 , La Rana G. 1 , Russo R. 1 , Sasso O. 1 , Iacono A. 1 , Esposito E. 1 , Cuzzocrea<br />
S. 2 , Meli R. 1 , Calignano A. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II <strong>di</strong> Napoli; 2 Dipartimento <strong>di</strong><br />
Me<strong>di</strong>cina e Farmacologia Clinica e Sperimentale, Università <strong>di</strong> Messina<br />
Il recettore PPAR-alfa centrale modula lo sviluppo dell’edema da carragenina nel topo.<br />
Lattanzi Roberta 1 , Giannini E. 1 , Campese A. 2 , Negri L. 1 , Melchiorri P. 1<br />
1 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, Università <strong>di</strong> Roma La Sapienza; 2 Dipartimento <strong>di</strong><br />
Me<strong>di</strong>cina Sperimentale e Patologia, Università <strong>di</strong> Roma La Sapienza<br />
Le prochineticine contribuiscono al dolore infiammatorio.<br />
Conti Silvia, Bertorelli R., Forlani A., Fredduzzi S., Nicolussi E., Reggiani A.<br />
Schering Plough Research Institute, Milano<br />
Ruolo del GW842166X, un agonista del recettore cannabico CB2, in <strong>di</strong>versi modelli <strong>di</strong> dolore<br />
neuropatico e infiammatorio nel ratto.<br />
50<br />
Cosentino Marco 1 , Zaffaroni M. 2 , Carcano E. 1 , Saporiti F. 1 , Ferrari M. 1 , Rasini E. 1 , Bombelli<br />
R. 1 , Perusin M. 1 , Grezzi A. 2 , Comi G. 2,3 , Marino F. 1 , Lecchini S. 1<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica, Sezione <strong>di</strong> Farmacologia Sperimentale e Clinica, Università<br />
dell’Insubria, Varese; 2 Centro per lo <strong>Stu<strong>di</strong></strong>o della Sclerosi Multipla, Ospedale <strong>di</strong> Gallarate, Varese;<br />
3 Istituto Scientifico S Raffaele Milano<br />
L’interferone-beta inibisce in vitro la funzionalità dei linfociti regolatori CD4+CD25+: ruolo <strong>di</strong><br />
meccanismi dopaminergici autocrini/paracrini.<br />
Simposio<br />
I nuovi farmaci target-specifici in oncologia<br />
SALA 6<br />
08.30-11.00<br />
Moderatori: Mantovani G (Cagliari) Mazzei T (Firenze)<br />
08.30/09.00 Fontanini G (Pisa)<br />
Patologia molecolare dei recettori dei fattori <strong>di</strong> crescita e delle chinasi nelle neoplasie<br />
solide<br />
09.00/09.30 Mini E (Firenze)<br />
Inibitori <strong>di</strong> EGFR e VEGF nella terapia dei tumori del tratto gastrointestinale<br />
09.30/10.00 Massidda B (Cagliari)<br />
Terapia target-specifica nel carcinoma polmonare non a piccole cellule<br />
10.00/10.30 Danesi R (Pisa)<br />
Integrazione <strong>di</strong> farmaci ad azione target-specifica con chemioterapia convenzionale<br />
10.30/11.00 Gebbia N (Palermo)<br />
Farmaci a bersaglio molecolare e pre<strong>di</strong>ttività della risposta<br />
pag_sx.indd 1 30/05/2007 2.10.01
Simposio<br />
Meccanismi d'azione <strong>degli</strong> antidepressivi: nuove acquisizioni<br />
SALA 7<br />
08.30-11.00<br />
Moderatore: Di Chiara G (Cagliari)<br />
08.30/09.00 Borsini F (Roma)<br />
Sviluppo delle teorie sul meccanismo d’azione <strong>degli</strong> antidepressivi<br />
09.00/09.30 Invernizzi R (Milano)<br />
Ruolo della triptofano idrosilasi-2 nella risposta agli SSRI: stu<strong>di</strong> comportamentali e <strong>di</strong><br />
micro<strong>di</strong>alisi nel topo<br />
09.30/10.00 Di Chiara G (Cagliari)<br />
Trattamento cronico con desipramina ed escitalopram su micro<strong>di</strong>alisi e ruolo dei<br />
recettori alfa2 e 5HT1A<br />
10.00/10.30 Demontis G (Siena)<br />
Mo<strong>di</strong>ficazioni dell’attività dell’asse ipotalamo-ipofisi-surrene in un modello<br />
sperimentale <strong>di</strong> depressione ed effetti dell’imipramina<br />
10.30/11.00 Spampinato U (Bordeaux)<br />
Interazione recettori 5HT2C e DA in corteccia<br />
Simposio<br />
Farmaci-farmacisti-farmacie<br />
Moderatori: Fioretti MC (Perugia) Fantozzi R (<strong>Torino</strong>)<br />
08.30/08.55 Diana P (Iglesias)<br />
La professione del farmacista<br />
Sessione ECM<br />
08.55/09.20 Fioretti MC (Perugia)<br />
SOT (OTC e SP): farmaci sicuri? Un'opportunità da non perdere in termini <strong>di</strong><br />
professionalità<br />
09.20/09.45 Massi M (Camerino)<br />
La formazione post-laurea del farmacista<br />
09.45/10.10 Fantozzi R (<strong>Torino</strong>)<br />
Il farmacista e le emergenze terapeutiche<br />
10.10/10.30 Filippi U (Milano)<br />
Il farmacista e la farmacia vista dall'industria<br />
10.30/11.00 Discussione<br />
SALA 8<br />
08.30-11.00<br />
51<br />
pag_dx.indd 1 30/05/2007 2.05.10
Sessione Plenaria<br />
La ricerca clinica in Italia: attualità e prospettive<br />
AUDITORIUM<br />
11.00-13.00<br />
Moderatori: Rossi F (Napoli) Scatigna M (Firenze)<br />
11.00/11.20 Tomino C (Roma)<br />
Attuale normativa e previsti cambiamenti nell'assetto regolatorio della<br />
sperimentazione clinica<br />
11.20/11.40 Scatigna M (Firenze)<br />
Ruolo dell'Italia nello sviluppo clinico farmaceutico<br />
11.40/12.00 Rossi F (Napoli)<br />
Il ruolo dell'Università nella ricerca clinica nazionale<br />
12.00/12.20 Vella S (Roma)<br />
La ricerca farmacologica nel VII programma quadro dell’Unione Europea<br />
12.20/12.40 Cricelli C (Firenze)<br />
La ricerca clinica in me<strong>di</strong>cina generale<br />
12.40/13.00 Discussione<br />
Realizzato con il contributo educazionale <strong>di</strong> Eli Lilly<br />
52<br />
pag_sx.indd 1 30/05/2007 2.07.46
FARMACOLOGIA DEL SISTEMA CARDIOVASCOLARE<br />
Pranzo riservato ai partecipanti<br />
SALA 3<br />
12.30-17.30<br />
12.30-13.00<br />
Simposio<br />
Appropriatezza nella terapia farmacologica car<strong>di</strong>ovascolare<br />
Incontro con l'Esperto<br />
Inibizione della corrente pacemaker IF: dall'elettrofisiologia alla<br />
pratica clinica<br />
13.00-14.30<br />
14.30-15.30<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Farmacologia car<strong>di</strong>ovascolare 15.30-17.30<br />
Simposio<br />
Appropriatezza nella terapia farmacologica car<strong>di</strong>ovascolare<br />
Moderatori: Biggio G (Cagliari) Lai C (Cagliari) Mugelli A (Firenze)<br />
13.00/13.30 Gaspardone A (Roma)<br />
Meccanismi <strong>di</strong> protezione vascolare <strong>degli</strong> inibitori dell'HMGCO-A reduttasi<br />
13.30/14.00 Caputi AP (Messina)<br />
Concetti <strong>di</strong> compliance, aderenza e continuità terapeutica nella patologia<br />
car<strong>di</strong>ovascolare: il punto <strong>di</strong> vista del farmacologo<br />
14.00/14.30 Colivicchi F (Roma)<br />
L'appropriatezza terapeutica nell'ambito delle statine: il punto <strong>di</strong> vista del clinico<br />
53<br />
Realizzato con il contributo educazionale <strong>di</strong> Pfizer<br />
Incontro con l'Esperto<br />
Sessione ECM<br />
Inibizione della corrente pacemaker IF: dall'elettrofisiologia alla pratica clinica<br />
Moderatori: Lai C (Cagliari) Mugelli A (Firenze)<br />
14.30/14.50 Mugelli A (Firenze)<br />
Inibizione della corrente pacemaker IF: il punto <strong>di</strong> vista del farmacologo<br />
14.50/15.10 Lai C (Cagliari)<br />
Inibizione della corrente pacemaker IF: il punto <strong>di</strong> vista del car<strong>di</strong>ologo<br />
15.10/15.30 Mugelli A (Firenze) Lai C (Cagliari)<br />
Discussione con gli esperti<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Farmacologia car<strong>di</strong>ovascolare<br />
Moderatori: Berrino L (Napoli) Tremoli E (Milano)<br />
Giuliani Daniela 2 , Colombo G. 1 , Sor<strong>di</strong> A. 1 , Lonati C. 1 , Mioni C. 2 , Leonar<strong>di</strong> P. 1 , Carlin A. 1 ,<br />
Bertolini A. 3 , Grieco P. 4 , Bazzani C. 2 , Catania A. 1 , Guarini S. 2<br />
1 Centro <strong>di</strong> Ricerca Preclinica, Fondazione IRCC, Ospedale Maggiore Policlinico, Mangiagalli e Regina<br />
Elena, Milano; 2 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena e<br />
Reggio Emilia; 3 Divisione Clinica Farmacologica, Università <strong>di</strong> Modena e Reggio Emilia; 4 Dipartimento<br />
<strong>di</strong> Chimica Farmaceutica e Tossicologica, Università Federico II <strong>di</strong> Napoli<br />
Basi molecolari dell’effetto protettivo conseguente a stimolazione del recettore melanocortinico MC4<br />
nello shock emorragico.<br />
pag_dx.indd 1 30/05/2007 2.11.58
Bitto Alessandra 1 , Minutoli L. 1 , Altavilla D. 1 , Polito F. 1 , Fiumara T. 1 , Di Stefano V. 1 , Giuliani<br />
D. 2 , Guarini S. 2 , Caputi A.P. 1 , Squadrito F. 1<br />
1 Dipartimento Clinico Sperimentale <strong>di</strong> Me<strong>di</strong>cina e Farmacologia, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong><br />
Messina; 2 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena e<br />
Reggio Emilia<br />
La terapia con simvastatina stimola la produzione <strong>di</strong> VEGF e migliora la cicatrizzazione delle ferite nel<br />
<strong>di</strong>abete sperimentale.<br />
Calabresi Laura 2 , Eberini I. 1 , Gianazza E. 1 , Gomaraschi M. 2 , Mombelli G. 2 , Breghi L. 3 ,<br />
Klugmann S 4 , Brusoni B 4 , Franceschini G 2 , Sirtori CR 2<br />
1 Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano, 2 Centro Grossi Paoletti, Dipartimento<br />
<strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano; 3 Divisione <strong>di</strong> Car<strong>di</strong>ologia, Ospedale <strong>di</strong> Circolo <strong>di</strong><br />
Voghera; 4 Divisione <strong>di</strong> Car<strong>di</strong>ologia, Ospedale <strong>di</strong> Niguarda, Milano; 5 Divisione <strong>di</strong> Car<strong>di</strong>ologia, Ospedale<br />
Fatebenefratelli, Milano<br />
Degradazione dell’apolipoproteina A-I da parte <strong>di</strong> farmaci trombolitici in pazienti infartuati.<br />
Camera Marina 1,2 , Brambilla M. 1 , Colnago D. 2 , De Metrio M. 2 , Marenzi G.C. 2 , Gertow K. 2 ,<br />
Tremoli E. 1,2<br />
1 Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano, 2 Centro Car<strong>di</strong>ologico Monzino IRCCS,<br />
Milano<br />
Caratterizzazione dell’espressione <strong>di</strong> Tissue Factor in piastrine, leucociti ed aggregati leucocitipiastrine<br />
<strong>di</strong> pazienti con malattia coronarica.<br />
54<br />
Tacconelli Stefania 1 , Di Febbo C. 1 , Douville K. 2 , Guglielmi M.D. 1 , Capone M.L. 1 , Porreca E. 1 ,<br />
Hwa J. 2 , Patrignani P. 1<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina e invecchiamento G d’Annunzio, Università e Fondazione G d’Annunzio,<br />
Chieti; 2 Dartmouth Me<strong>di</strong>cal Sch, Hanover, NH<br />
Polimorfismi del recettore umano della prostaciclina e eterogenesi.<br />
Parenti Astrid, Vinci M.C., Bellik L., Filippi S., Ledda F.<br />
Laboratorio <strong>di</strong> Farmacologia Vascolare, Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong><br />
Firenze<br />
La stimolazione dei recettori alfa-1D adrenergici induce effetti trofici sulle cellule endoteliali: ruolo<br />
dell’ipossia.<br />
Barbieri Silvia S 1,2 , Tremoli E. 2 , Weksler B.B. 1<br />
1 Division of Hematology-Me<strong>di</strong>cal Oncology, Weill Me<strong>di</strong>cal College of Cornell University, New York, NY,<br />
USA; 2 Dipartimento <strong>di</strong> Scienze Farmacologiche Università <strong>di</strong> Milano<br />
Il fumo <strong>di</strong> sigaretta coopera con IL-1 nell'alterare il trafficking <strong>di</strong> -catenina nell'endotelio vascolare<br />
con conseguente aumento della permeabilità e dell'espressione <strong>di</strong> cicloossigenase-2 in vivo e in vitro.<br />
Bucci Mariarosaria 1 , Roviezzo F. 1 , Brancaleone V. 1 , Di Lorenzo A. 1 , Rizzo G. 2 , Vellecco<br />
V. 1 , Fiorucci S. 1 , Cirino G. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II <strong>di</strong> Napoli; 2 Dipartimento <strong>di</strong><br />
Me<strong>di</strong>cina Clinica e Sperimentale, Laboratorio <strong>di</strong> Biologia Molecolare, Università <strong>di</strong> Perugia<br />
La vaso<strong>di</strong>latazione da testosterone è me<strong>di</strong>ata dal rilascio <strong>di</strong> H2S nell’aorta <strong>di</strong> ratto<br />
pag_sx.indd 1 30/05/2007 2.13.28
Sessione Poster<br />
13.00-15.00<br />
Colazione <strong>di</strong> lavoro<br />
13.00-14.00<br />
Sessione ECM<br />
Simposio<br />
Glucocorticoi<strong>di</strong>, meccanismi molecolari ed efficacia<br />
antinfiammatoria ed immunosoppressiva<br />
Moderatori: Fioretti MC (Perugia) Riccar<strong>di</strong> C (Perugia)<br />
15.00/15.25 Riccar<strong>di</strong> C (Perugia)<br />
Glucocorticoi<strong>di</strong> nel controllo della crescita cellulare: ruolo <strong>di</strong> GILZ<br />
AUDITORIUM<br />
15.00-17.30<br />
15.25/15.50 Parente L (Salerno)<br />
Inibizione da parte del desametasone dell'apoptosi indotta da TRAIL in cellule <strong>di</strong><br />
carcinoma tiroideo<br />
15.50/16.15 Grohmann U (Perugia)<br />
Il catabolismo del triptofano come nuovo meccanismo d'azione dei glucocorticoi<strong>di</strong><br />
nell'infiammazione allergica delle vie respiratorie<br />
16.15/16.40 Cuzzocrea S (Messina)<br />
L’assenza del recettore PPAR- funzionale inibisce l’effetto antinfiammatorio dei<br />
glucocorticoi<strong>di</strong><br />
16.40/17.05 Cirino G (Napoli)<br />
I glucocorticoi<strong>di</strong> donatori <strong>di</strong> ossido nitrico (NO) mostrano proprietà farmacologiche che<br />
si traducono in benefici clinici<br />
17.05/17.30 Discussione<br />
55<br />
Simposio<br />
Angiogenesi tumorale e terapia antiangiogenica<br />
SALA 1<br />
15.00-17.30<br />
Moderatori: Ziche M (Siena) Spano PF (Brescia)<br />
15.00/15.30 Kerbel R (Toronto)<br />
Terapia antiangiogenica e ottimizzazione dell'efficacia della chemioterapia<br />
convenzionale<br />
15.30/16.00 Mochly-Rosen D (Stanford)<br />
La PKC influenza le funzioni vascolari e la crescita del tumore della prostata<br />
16.00/16.30 Melillo G (Frederick)<br />
Hypoxia Inducible Factor 1 (HIF-1) come bersaglio per la terapia antitumorale<br />
16.30/17.00 Ziche M (Pisa)<br />
Angiogenesi e infiammazione: il circolo vizioso <strong>di</strong> PGE2 e recettori tirosin chinasici<br />
17.00/17.30 Mini E (Firenze)<br />
Sviluppo clinico <strong>di</strong> enzastaurin, un inibitore della protein chinasi C beta: attualità e<br />
prospettive<br />
Realizzato con il contributo educazionale <strong>di</strong> Eli Lilly, Cell Therap. Europe<br />
pag_dx.indd 1 30/05/2007 2.15.01
Sessione ECM<br />
Simposio<br />
Lo stress nella patologia mentale: comportamento, neurobiologia<br />
e trattamento<br />
Moderatori: Riva MA (Milano) Serra M (Cagliari)<br />
SALA 2<br />
15.00-17.30<br />
15.00/15.25 Maccari S (Villeneuve d'Ascq)<br />
Lo stress prenatale ha effetti sulla plasticità cerebrale nella <strong>di</strong>scendenza adulta:<br />
<strong>di</strong>fferenze sessuali<br />
15.25/15.50 Serra M (Cagliari)<br />
Influenza dello stress cronico sui livelli <strong>degli</strong> steroi<strong>di</strong> neuroattivi, sulla plasticità e la<br />
funzione del recettore GABA A<br />
15.50/16.15 Gass P (Mannheim)<br />
Modelling depression through glucocorticoid receptor transgenic mice<br />
16.15/16.40 Dazzi L (Cagliari)<br />
Controllo farmacologico delle alterazioni indotte dallo stress nel rilascio dei<br />
neurotrasmettitori<br />
16.40/17.05 Riva MA (Milano)<br />
Stress, plasticità neuronale e vulnerabilità alle malattie psichiatriche<br />
17.05/17.30 Discussione<br />
56<br />
Cre<strong>di</strong>ti ECM assegnati 2<br />
Simposio<br />
Atomoxetina, nuova alternativa terapeutica per il trattamento del<br />
<strong>di</strong>sturbo da deficit dell'attenzione e iperattività (ADHD)<br />
Moderatori: Biggio G (Cagliari) Zuddas A (Cagliari)<br />
15.00/15.30 Biggio G (Cagliari)<br />
Cosa succede nel cervello <strong>di</strong> un bambino con ADHD?<br />
15.30/15.55 Masi G (Pisa)<br />
Un bambino con ADHD sarà anche un uomo con ADHD?<br />
SALA 4<br />
15.00-17.30<br />
15.55/16.20 Bymaster F (In<strong>di</strong>anapolis)<br />
Atomoxetina, un nuovo farmaco non-psicostimolante per il trattamento del ADHD<br />
16.20/16.45 Zuddas A (Cagliari)<br />
Risultati <strong>di</strong> un trial a lungo termine sull'impiego <strong>di</strong> atomoxetina nella prevenzione delle<br />
reci<strong>di</strong>ve nel ADHD<br />
16.45/17.10 Dell'Agnello G (Firenze)<br />
Risultati preliminari <strong>di</strong> uno stu<strong>di</strong>o italiano sull'efficacia <strong>di</strong> atomoxetina in pazienti con<br />
ADHD e Disturbo Oppositivo Provocatorio (ODD)<br />
17.10/17.30 Discussione e Questionario ECM<br />
Realizzato con il contributo educazionale <strong>di</strong> Eli Lilly<br />
pag_sx.indd 1 30/05/2007 2.18.56
Sessione <strong>di</strong> Comunicazioni Orali<br />
Nuove acquisizioni sulla farmacologia <strong>di</strong> genere<br />
SALA 5<br />
15.00-17.30<br />
Moderatori: Eva C (<strong>Torino</strong>) Serra G (Sassari)<br />
Trabace Luigia 1 , Colaianna M. 1 , Castrignanò S. 1 , Cassano T. 1 , Tucci P. 1 , Cuomo V. 2<br />
1 Dip. Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Foggia; 2 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia V.<br />
Erspamer, Università <strong>di</strong> Roma “La Sapienza”<br />
Differenze <strong>di</strong> genere nella modulazione indotta da ossido nitrico della trasmissione dopaminergica<br />
nella corteccia prefrontale <strong>di</strong> ratto.<br />
Morale Maria Concetta 1 , Giaquinta G. 1 , Caniglia S. 1 , L’Episcopo F. 1 , Tirolo C. 1 , Testa N. 1 ,<br />
Arcieri P. 1 , Marchetti B. 1.2<br />
1 OASI Scientific Institute (IRCCS) Troina (EN), 2 Dipartimento Farmacologia Fac Me<strong>di</strong>cina Università <strong>di</strong><br />
Sassari<br />
Stato infiammatorio “pre-esistente”, genere e deficienza <strong>di</strong> estrogeni: una finestra terapeutica per il<br />
targeting farmacologico della malattia <strong>di</strong> Parkinson.<br />
Patacchioli Francesca Romana, Monnazzi P., Martelletti P. 1 , Simeoni S.<br />
Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia V. Erspamer, Università La Sapienza, Roma; 1 Dip.<br />
Me<strong>di</strong>cina Interna, Università La Sapienza, Roma<br />
Effetti della tossina botulinica tipo-A su in<strong>di</strong>ci ormonali <strong>di</strong> benessere fisico in donne affette da<br />
emicrania cronica.<br />
Zavatti Manuela, Montanari C., Geminiani E., Ricchi L., Corsi L., Zanoli P.<br />
Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Modena e Reggio Emilia<br />
Influenza della ferutinina sul comportamento sessuale del ratto femmina.<br />
57<br />
Canu Silvia 1 , Carta S. 1 , Loizzo S. 2 , Guarino I. 1 , Carru C. 3 , Zinellu A. 3 , Loizzo A. 2 , Franconi F. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Sassari; 2 Istituto Superiore <strong>di</strong> Sanità, Roma;<br />
3 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Sassari, Istituto Nazionale delle Biostrutture e<br />
Biosistemi (INBB), Osilo- Sassari<br />
L’handling neonatale induce un incremento nella curva <strong>di</strong> incremento <strong>di</strong> peso corporeo <strong>di</strong> entrambi i<br />
sessi.<br />
Moderatori: Pataccioli FR (Roma) Viano I (Novara)<br />
Vicentini Lucia M, Cattaneo M.G., Chini B. 1<br />
Dipartimento <strong>di</strong> Farmacologia, Milano; 1 CNR, Centro <strong>di</strong> Farmacologia Cellulare e Molecolare, Milano<br />
Nuovi possibili ruoli patofisiologici per l’ossitocina.<br />
Malorni Walter 1 , Coinu R. 2 , Carta S. 2 , Campesi I. 2 , Straface E. 1 , Matarrese P. 1 , Franconi F. 2<br />
1 Dipartimento del Farmaco, Istituto Superiore <strong>di</strong> Sanità, Roma; 2 Dipartimento <strong>di</strong> Scienze Fisiologiche,<br />
Biochimiche e Cellulari, Università <strong>di</strong> Sassari<br />
Cellule muscolari lisce vasali: stato redox e <strong>di</strong>fferenze <strong>di</strong> genere.<br />
Cignarella Andrea 1,2 , Bolego C. 1 , Vegeto E. 1 , Pelosi V. 1,2 , Meda C. 1 , Maggi A. 1<br />
1 Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Milano; 2 Dipartimento <strong>di</strong> Farmacologia ed<br />
Anestesiologia, Università <strong>di</strong> Padova<br />
Il recettore alfa per gli estrogeni è implicato nella regolazione dell’omeostasi del glucosio e nella<br />
risposta vascolare alle citochine infiammatorie nel topo.<br />
pag_dx.indd 1 30/05/2007 2.20.37
Marini Herbert 1 , Minutoli L. 2 , Polito F. 2 , Bitto A. 2 , Altavilla D. 2 , Frisina N. 3 , D’Anna R. 5 ,<br />
Lubrano C. 5 , Adamo E.B. 1 , Caputi A.P. 2 , Squadrito F. 2<br />
1 Dipartimento <strong>di</strong> Scienze Biochimiche, Fisiologiche e della Nutrizione, Sezione <strong>di</strong> Fisiologia e<br />
Nutrizione Umana, Università <strong>di</strong> Messina, 2 Dipartimento Clinico-Sperimentale <strong>di</strong> Me<strong>di</strong>cina e<br />
Farmacologia, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong> Messina, 3 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Interna,<br />
Università <strong>di</strong> Messina, 4 Dipartimento <strong>di</strong> Scienze Ostetriche e Ginecologiche, Università <strong>di</strong> Messina;<br />
5 Dipartimento <strong>di</strong> Fisiopatologia Me<strong>di</strong>ca, Università “La Sapienza”, Roma<br />
Effetti del fitoestrogeno genisteina sul metabolismo osseo in donne osteopeniche, in post-menopausa:<br />
un trial clinico randomizzato.<br />
Aviello Gabriella 1 , Ernst E. 2 , Capasso R. 1 , Capasso F. 1 , Borrelli F. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II <strong>di</strong> Napoli; 2 Complementary<br />
Me<strong>di</strong>cine, Peninsula Me<strong>di</strong>cal School, Universities of Exeter and Plymouth, 25 Victoria Park Road,<br />
Exeter EX2 4NT, UK.<br />
Revisione sistematica sull’efficacia e sicurezza della Cimicifuga racemosa.<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Farmaci antitumorali<br />
SALA 7<br />
15.00-17.30<br />
58<br />
Moderatori: Baral<strong>di</strong> M (Modena) Onali PL (Cagliari)<br />
Ayrol<strong>di</strong> Emira, Bastianelli A., Marchetti C., Velar<strong>di</strong> E., Agostani M., Donato V., Bruscoli S.,<br />
Riccar<strong>di</strong> C.<br />
Istituto <strong>di</strong> Farmacologia, Dipartimento Med. Clinica e Sperimentale, Università <strong>di</strong> Perugia<br />
Gilz modula negativamente proliferazione e segnali oncogenici <strong>di</strong>pendenti dall’attivazione <strong>di</strong> ras.<br />
Baiula Monica, Di Toro R., Spampinato S.<br />
Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Bologna<br />
L’espressione del fattore <strong>di</strong> trascrizione rest, ridotta in cellule <strong>di</strong> neuroblastoma esposte a pma, è<br />
stabilizzata da un inibitore delle proteasi, correlandosi in senso inverso al <strong>di</strong>fferenziamento neuronale<br />
Corsi Lorenzo, Geminiani E., Ricchi L., Baral<strong>di</strong> M.<br />
Dip. Scienze Biome<strong>di</strong>che Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Modena e Reggio Emilia<br />
CINSPAN Consorzio Interuniversitario Nazionale per lo <strong>Stu<strong>di</strong></strong>o dei Principi Attivi Naturali<br />
Coinvolgimento dei recettori periferici delle benzo<strong>di</strong>azepine nei processi proliferativi tumorali e nella<br />
produzione <strong>di</strong> ROS.<br />
Fimognari Carmela, Lenzi M., Cantelli-Forti G., Hrelia P.<br />
Dipartimento <strong>di</strong> Farmacologia, Università <strong>di</strong> Bologna<br />
Percorsi molecolari alla base dell’attività antileucemica del sulforafane.<br />
De Francia Silvia 1 , De Martino F. 1 , Pirro E. 1 , Piccione F. 1 , Sprio A.E. 1 , Di Carlo F. 1 , Mussa<br />
M.V. 2 , Daffara F. 3 , Reimondo G. 3 , Zaggia B. 3 , Terzolo M. 3 , Angeli A. 3<br />
1 Laboratorio <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Scienze Cliniche e Biologiche, Università <strong>di</strong> <strong>Torino</strong>,<br />
2 Scuola Infermieri, Università <strong>di</strong> <strong>Torino</strong>, 3 Me<strong>di</strong>cina Interna, Dipartimento <strong>di</strong> Scienze Cliniche e<br />
Biologiche, Università <strong>di</strong> <strong>Torino</strong><br />
<strong>Stu<strong>di</strong></strong>o prospettico <strong>degli</strong> effetti biochimici della somministrazione <strong>di</strong> mitotane in pazienti con carcinoma<br />
corticosurrenalico.<br />
Rosa Arianna Carolina, Gallicchio M., Dianzani C., Brucato L., Collino M., Fantozzi R.<br />
Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale. Università <strong>di</strong> <strong>Torino</strong><br />
Effetti del celecoxib sull'espressione <strong>di</strong> ICAM-1 e VCAM-1 nelle HT29.<br />
pag_sx.indd 1 30/05/2007 2.29.55
D’Acunto Cosimo Walter, Festa M., Tosco A., Rodriguez M., Petrella A., Parente L.<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, Università <strong>di</strong> Salerno<br />
Effetti del nuovo inibitore <strong>di</strong> deacetilasi FR235222 in cellule promonocitiche umane U937: Ruolo della<br />
Annessina A1.<br />
Di Paolo Antonello 1 , Amatori F. 1 , Lencioni M. 2 , Bocci G. 1 , Orlan<strong>di</strong>ni C. 2 , Ciofi L. 1 , Lastella M. 1 ,<br />
Falcone A. 3 , Ricci S. 2 , Del Tacca M. 1 , Danesi R. 1<br />
1 Divisione <strong>di</strong> Farmacologia e Chemioterapia, Dipartimento <strong>di</strong> Me<strong>di</strong>cina Interna, Università <strong>di</strong> Pisa;<br />
2 Unità Operativa <strong>di</strong> Oncologia Me<strong>di</strong>ca, Azienda Ospedaliera Universitaria Pisana, Pisa; 3 Unità Operativa<br />
<strong>di</strong> Oncologia Me<strong>di</strong>ca, Ospedale Civile, Livorno<br />
L’esposizione a 5-fluorouracile è associata alla sopravvivenza libera da malattia in pazienti affetti da<br />
carcinoma colorettale in trattamento con chemioterapia a<strong>di</strong>uvante.<br />
Bellik Ly<strong>di</strong>a 1 , Parenti A. 1 , Vinci M.C. 1 , Gerlini G. 2 , Pantalone D. 3 , Ledda F. 1<br />
1 Laboratorio <strong>di</strong> Farmacologia Vascolare, Dipartimento <strong>di</strong> Farmacologica Clinica e Preclinica,<br />
2 Dipartimento <strong>di</strong> Scienze Dermatologiche, 3Dipartimento <strong>di</strong> Area Critico Me<strong>di</strong>co Chirurgica, Università<br />
<strong>di</strong> Firenze<br />
Effetto dei trattamenti convenzionali sulle cellule dendritiche in pazienti con cancro colorettale.<br />
Mognetti Barbara 1 , Berta G.N. 1 , Spadaro M. 1 , Cavallo F. 1 , Barberis A. 1 , Papotti M. 1 , Amici A. 2 ,<br />
Iezzi M. 3 , Musiani P. 3 , Forni G. 1 , Di Carlo F. 1<br />
1 Dipartimento Scienze Cliniche e Biologiche, Università <strong>di</strong> <strong>Torino</strong>; 2 Dipartimento <strong>di</strong> Biologia Molecolare,<br />
Cellulare e Animale, Università <strong>di</strong> Camerino; 3 Centro <strong>di</strong> ricerche sull’invecchiamento Fondazione<br />
Università “Gabriele D'Annunzio Chieti<br />
Valutazione preclinica <strong>di</strong> un nuovo approccio terapeutico: la vaccinazione a dna protegge dal<br />
carcinoma squamoso orale chimicamente indotto.<br />
59<br />
Simposio<br />
I modelli animali nella ricerca biome<strong>di</strong>ca<br />
(<strong>SIF</strong> - EBRA)<br />
SALA 8<br />
15.00-17.30<br />
Moderatori: Jori A (Milano) Drago F (Catania)<br />
15.00/15.20 Meneguz A (Milano)<br />
L'impiego dei modelli animali nella ricerca preclinica secondo le GLP<br />
15.20/15.40 Collu M (Cagliari)<br />
Modelli animali in psichiatria e neuropsicofarmacologia: vali<strong>di</strong>tà e limiti<br />
15.40/16.00 Cerbai E (Firenze)<br />
I modelli animali nella ricerca in area car<strong>di</strong>ovascolare<br />
16.00/16.20 Blan<strong>di</strong>zzi C (Pisa)<br />
Modelli animali in gastroenterologia<br />
16.20/16.40 Morigi M (Bergamo)<br />
Cellule staminali e modelli animali <strong>di</strong> danno renale<br />
16.40/17.30 Discussione<br />
Assemblea dei soci<br />
AUDITORIUM<br />
17.30-19.30<br />
pag_dx.indd 1 30/05/2007 2.32.10
Simposio<br />
Target molecolari del dolore cronico<br />
SALA 1<br />
08.30-11.00<br />
Moderatori: Canonico PL (Novara) Sortino MA (Catania)<br />
08.30/08.50 Negri L (Roma)<br />
Meccanismi peptidergici della nocicezione<br />
08.50/09.10 Maione S (Napoli)<br />
Meccanismi <strong>di</strong> plasticità nei nuclei sopraspinali che regolano la soglia del dolore<br />
09.10/09.30 Nicoletti F (Roma)<br />
I meccanismi periferici e midollari <strong>di</strong> sensibilizzazione nocicettiva come target <strong>di</strong><br />
farmaci analgesici<br />
09.30/09.50 Cipollone F (Chieti)<br />
Espressione <strong>di</strong> COX-2 in piastrine e monociti come potenziale base del fallimento della<br />
terapia con ASA nel paziente <strong>di</strong>abetico<br />
09.50/10.10 Blan<strong>di</strong>zzi C (Pisa)<br />
Farmaci inibitori selettivi della COX-2 e meccanismi <strong>di</strong> protezione e riparazione della<br />
mucosa gastrointestinale<br />
10.10/11.00 Discussione<br />
60<br />
Realizzato con il contributo educazionale <strong>di</strong> Pfizer<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Farmacologia <strong>di</strong> Scienze<br />
SALA 2<br />
08.30-12.15<br />
Moderatori: Maura G (Genova) Pedata F (Firenze)<br />
Carmignani Marco 1 , Cesare P. 1 , Fanelli R. 2 , Valle G. 3 , Volpe A.R. 1<br />
1 Dipartimento <strong>di</strong> Biologia <strong>di</strong> Base ed Applicata, Sezione <strong>di</strong> Farmacologia e Tossicologia, Università <strong>di</strong><br />
L’Aquila; 2 IRCCS – Casa Sollievo della Sofferenza - Sezione <strong>di</strong> Car<strong>di</strong>ologia, S. Giovanni Rotondo (FG);<br />
3 IRCCS – Casa Sollievo della Sofferenza - Sezione <strong>di</strong> Me<strong>di</strong>cina Nucleare, S. Giovanni Rotondo (FG)<br />
Livelli critici <strong>di</strong> ipoperfusione splancnica: fattore critico <strong>di</strong> shock ipo<strong>di</strong>namico irreversibile da aumento<br />
<strong>di</strong> nitrossido plasmatico indotto da rilascio intestinale <strong>di</strong> encefalite.<br />
Giar<strong>di</strong>na Silvana, Marzani B., Marzatico F.<br />
Dipartimento <strong>di</strong> Scienze Fisiologiche e Farmacologiche Cellulari e Molecolari, Sez. Farmacologia e<br />
Biotecnologie Farmacologiche; Università <strong>di</strong> Pavia<br />
Valutazione “in vivo” <strong>degli</strong> enzimi antiossidanti e della perossidazione lipi<strong>di</strong>ca a <strong>di</strong>fferenti livelli dello<br />
strato corneo umano.<br />
Botti Francesca 1 , Ottolina A. 2 , Marcuzzo S. 1 , Mennini T. 3 , Parati E. 2 , Tonini M. 1 , Curti D. 1<br />
1 Dipartimento <strong>di</strong> Scienze Fisiologiche e Farmacologiche Celllari e Molecolari, Università <strong>di</strong> Pavia;<br />
2 Istituto Neurologico “C. Besta”, Milano; 3 Istituto Mario Negri, Milano<br />
Cellule staminali adulte come strumento per lo stu<strong>di</strong>o dei meccanismi responsabili del processo<br />
neurodegenerativo in topi con mutazione del gene per la proteina Vps54.<br />
pag_sx.indd 1 30/05/2007 2.36.18
Gessi Stefania 1 , Merighi S. 1 , Varani K. 1 , Fogli E. 1 , Sacchetto V. 1 , Benini A. 1 , Mirandola P. 2 ,<br />
Leung E. 3 , Mac Lennan S. 3 , Feo C. 4 , and Borea P.A. 1<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale Sez. Farmacologia, Università <strong>di</strong> Ferrara; 2 Dip. <strong>di</strong><br />
Anatomia Umana, Farmacologia e Me<strong>di</strong>cina Forense, Ist. <strong>di</strong> Anatomia Umana, Osp. Maggiore,<br />
Università <strong>di</strong> Parma; 3 King Pharm. Res. and Dev., Inc., Cary, North Carolina, 4 Dipartimento <strong>di</strong><br />
Chirurgia, Anestesiologia e Ra<strong>di</strong>ologia, Università <strong>di</strong> Ferrara<br />
Recettori dell’adenosina in tessuti tumorali e in linee cellulari <strong>di</strong> colon: “focus” sul recettore A3.<br />
Quintieri Luigi 1 , Fantin M 1 , Rosato A 2,3 , Caruso M 4 , Geroni C 4 , Nassi A 1 , Floreani M 1<br />
1 Dipartimento <strong>di</strong> Farmacologia ed Anestesiologia, Università <strong>di</strong> Padova; 2 Dipartimento <strong>di</strong> Scienze<br />
Oncologiche e Chirurgiche, Università <strong>di</strong> Padova; 3 Istituto Oncologico Veneto, Padova; 4 Nerviano<br />
Me<strong>di</strong>cal Sciences S.r.l., Nerviano<br />
Confronto interspecie della biotrasformazione epatica dell’antitumorale nemorubicina nel suo<br />
metabolita attivo PNU-159682.<br />
Monti Elena, Molteni R., Marras E., Perletti G., Ravizza R., Garibol<strong>di</strong> M.B.<br />
Dipartimento Biologia Strutturale e Funzionale, Università dell’Insubria<br />
L’inibizione dell’espressione <strong>di</strong> hif-1 me<strong>di</strong>ante rna interference potenzia l’azione citotossica della<br />
doxorubicina in cellule <strong>di</strong> adenocarcinoma del colon umano.<br />
Intervallo 10.00/10.15<br />
Moderatori: Parolaro D (Varese) Sanna E (Cagliari)<br />
Capurro Valeria, Braida D., Zani A., Sala M.<br />
Dipartimento <strong>di</strong> Farmacologia, Chemioterapia e Tossicologia me<strong>di</strong>ca Università <strong>di</strong> Milano<br />
Coinvolgimento del sottotipo recettoriale CB1 nella risposta emozionale indotta dalla salvinorina a nel<br />
ratto.<br />
61<br />
Rubino Tiziana, Viganò D., Realini N. Guidali C., Parolaro D .<br />
DBSF e Centro <strong>di</strong> Neuroscienze, Università dell’Insubria<br />
Endocannabinoi<strong>di</strong> ed ansia: ruolo della corteccia prefrontale.<br />
Follesa Paolo 1,2 , Biggio F.1, Gorini G. 1 , Caria S., Mostallino M.C. 3 , Murru L. 1 , Sanna E. 1,2 ,<br />
Biggio G. 1,2,3<br />
1 Dipartimento <strong>di</strong> Biologia Sperimentale, Sezione <strong>di</strong> Neuroscienze, Università <strong>di</strong> Cagliari; 2 Centro <strong>di</strong><br />
Eccellenza per la Neurobiologia delle Dipendenze, 3 CNR Istituto <strong>di</strong> Neuroscienze, Unità <strong>di</strong><br />
Neuropsicofarmacologia, Cagliari<br />
Riduzione dell’espressione genica della subunità e della sensibilità del recettore GABA A<br />
all’allopregnanolone indotta dall’interruzione <strong>di</strong> un trattamento cronico con progesterone.<br />
Comelli Francesca 1 , Colleoni M. 2 , Giagnoni G. 1 , Costa B. 1<br />
1 Dipartimento <strong>di</strong> Biotecnologie Bioscienze, Università Milano-Bicocca; 2 Dipartimento <strong>di</strong><br />
Farmacologia, Università <strong>di</strong> Milano<br />
Effetto antiiperalgesico <strong>di</strong> un estratto <strong>di</strong> cannabis sativa in un modello <strong>di</strong> dolore neuropatico nel ratto:<br />
meccanismi implicati.<br />
Cipriani Sara 1 , Melani A. 1 , Gianfriddo M. 2 , Vannucchi M.G. 3 , Pedata F. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica M.A. Mancini, Università <strong>di</strong> Firenze; 2 Siena Biotech<br />
S.p.A., Siena; 3 Dipartimento <strong>di</strong> Anatomia, Istologia e Me<strong>di</strong>cina Forense, Università <strong>di</strong> Firenze<br />
Effetto dell’antagonismo selettivo del recettore adenosinico A 2A sul comportamento motorio e<br />
sull’espressione dell’ossido nitrico sintetasi neuronale nello striato <strong>di</strong> topi transgenici per la corea <strong>di</strong><br />
Huntington.<br />
pag_dx.indd 1 30/05/2007 2.38.07
Marcoli Manuela 1, Cervetto C. 1 , Paluzzi P. 1 , Guarnieri S. 1 , Maura G. 1,2<br />
1Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Sezione <strong>di</strong> Farmacologia e Tossicologia, Università <strong>di</strong><br />
Genova; 2Centro <strong>di</strong> Eccellenza per la Ricerca Biome<strong>di</strong>ca, Università <strong>di</strong> Genova<br />
Controllo da parte <strong>di</strong> cGMP dell’attivazione <strong>di</strong> recettori kainato nella corteccia cerebellare <strong>di</strong> ratto.<br />
Casale Federico, Ferretti C.<br />
Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale, Università <strong>di</strong> <strong>Torino</strong><br />
Modulazione colinergica dell’espressione <strong>di</strong> Egr-1 in cellule <strong>di</strong> neuroblastoma umano SK-n-BE.<br />
Corsini Daniela 1 , Alboni S. 1 , Blom J.M.C. 2 , Benatti C. 1 , Caggia F. 1 , Barden N. 3 , Brunello N. 1 ,<br />
Tascedda F. 1<br />
1 Dipartimento Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Modena e Reggio Emilia; 2 Dipartimento Pe<strong>di</strong>atria,<br />
Università <strong>di</strong> Modena e Reggio Emilia; 3 CHUL Research Center, Laval University, Quebec, Canada<br />
Regolazione dell’attività trascrizionale in ippocampo <strong>di</strong> topi transgenici per il recettore dei<br />
glucocorticoi<strong>di</strong> <strong>di</strong> tipo II: effetto dello stress da restraint.<br />
62<br />
Sessione ECM<br />
Simposio<br />
Terapia ormonale sostitutiva: se, quando, per quanto e perchè<br />
(<strong>SIF</strong> - AIGE)<br />
Moderatori: Genazzani AR (Pisa) Melis GB (Cagliari)<br />
SALA 3<br />
08.30-11.00<br />
08.30/08.50 Simoncini T (Pisa)<br />
Prevenzione car<strong>di</strong>ovascolare dopo la menopausa: quale ruolo per la terapia ormonale<br />
sostitutiva?<br />
08.50/09.10 Concas A (Cagliari)<br />
Neurosteroi<strong>di</strong>, plasticità neuronale e menopausa<br />
09.10/09.30 Genazzani AR (Pisa)<br />
Effetti centrali <strong>degli</strong> steroi<strong>di</strong>: dai sintomi alla prevenzione<br />
09.30/09.50 Nappi R (Pavia)<br />
Menopausa e sessualità: una terapia per la persona<br />
09.50/10.10 Paoletti A (Cagliari)<br />
L'ottimizzazione della dose e la personalizzazione del progestinico<br />
10.10/11.00 Discussione<br />
pag_sx.indd 1 30/05/2007 2.40.17
Simposio<br />
Aspetti cellulari e molecolari del precon<strong>di</strong>zionamento e<br />
postcon<strong>di</strong>zionamento ischemico: basi <strong>di</strong> intervento farmacologico<br />
SALA 5<br />
08.30-11.00<br />
Moderatori: Annunziato L (Napoli) Moroni F (Firenze)<br />
08.30/09.45 Pellegrini GD (Firenze)<br />
Modelli <strong>di</strong> precon<strong>di</strong>zionamento ischemico in fettine ippocampali: ruolo dei recettori al<br />
glutammato e della poli(ADP-ribosio) polimerasi<br />
09.45/10.00 Pizzi M (Brescia)<br />
Specificità dei complessi trascrizionali NF-kappaB nella regolazione della vulnerabilità<br />
all'ischemia cerebrale<br />
10.00/10.15 Scorziello A (Napoli)<br />
La neuroprotezione indotta dal Precon<strong>di</strong>zionamento anossico nei neuroni corticali è<br />
me<strong>di</strong>ata dall’NO e dalla Mn-SOD<br />
10.15/10.30 Pignataro G (Napoli)<br />
Postcon<strong>di</strong>tioning ischemico cerebrale, caratterizzazione molecolare <strong>di</strong> una nuova<br />
strategia neuroprotettiva<br />
Sessione ECM<br />
Simposio<br />
Basi farmacocinetiche/farmaco<strong>di</strong>namiche (PK/PD) per il corretto<br />
uso dei farmaci antimicrobici<br />
(<strong>SIF</strong> - SIC)<br />
Moderatori: Mazzei T (Firenze) Cricelli C (Firenze)<br />
08.30/09.00 Scaglione F (Milano)<br />
Basi (PK/PD) per il corretto uso dei farmaci antimicrobici<br />
09.00/09.30 Novelli A (Firenze)<br />
Variabili (PK/PD) in rapporto al paziente e agli organi<br />
09.30/10.00 Rossi A (Narni)<br />
Applicabilità dei criteri (PK/PD) nella pratica me<strong>di</strong>ca<br />
10.00/11.00 Discussione<br />
SALA 6<br />
08.30-11.00<br />
63<br />
pag_dx.indd 1 30/05/2007 2.41.38
64<br />
Sessione ECM<br />
Simposio<br />
Monossido <strong>di</strong> azoto (NO) ed infiammazione: prospettive<br />
terapeutiche<br />
Moderatori: Cantoni O (Urbino) Masini E (Firenze)<br />
SALA 7<br />
08.30-11.00<br />
08.30/08.50 Nisoli E (Milano)<br />
Ossido nitrico e mitocondriogenesi: rilevanza fisiopatologica nello sviluppo della<br />
sindrome metabolica<br />
08.50/09.10 Cantoni O (Urbino)<br />
La comprensione dei meccanismi <strong>di</strong> sopravvivenza delle cellule infiammatorie a<br />
NO/perossinitrito: un primo passo per lo sviluppo <strong>di</strong> nuove strategie farmacologiche<br />
per la terapia dell'infiammazione<br />
09.10/09.30 Clementi E (Milano)<br />
Ruolo del monossido <strong>di</strong> azoto e del controllo della infiammazione nella terapia delle<br />
<strong>di</strong>strofie muscolari<br />
09.30/09.50 Cirino G (Napoli)<br />
NOS endoteliale, sfingosina-1-fosfato ed infiammazione<br />
09.50/10.10 Madeddu P (Bristol)<br />
Statine che rilasciano ossido nitrico mostrano attività antinfiammatorie e riparative in<br />
modelli sperimentali <strong>di</strong> malattie car<strong>di</strong>ovascolari<br />
10.10/10.30 Masini E (Firenze)<br />
Monossido d'azoto e ceramide: un nuovo target per il controllo dell'infiammazione e<br />
dell'iperreattività bronchiale<br />
10.30/11.00 Discussione<br />
Sessione <strong>di</strong> Comunicazioni Orali<br />
Neurodegenerazione e neuroprotezione<br />
SALA 5<br />
11.00-13.00<br />
Moderatori: Memo M (Brescia) Parente L (Salerno)<br />
Marchetti Bianca 1,2 , Tirolo C. 1 , L’Episcopo F. 1 , Testa N. 1 , Caniglia S. 1 , Serra P.A. 2 , Rocchitta<br />
G. 2 , Giaquinta G. 1 , Morale M.C. 1 , Martino G. 3 , Plachino S. 3<br />
1 OASI Inst. (IRCCS) Troina (EN); 2 Dipartimento Farmacologia, Università <strong>di</strong> Sassari; 3 Unità <strong>di</strong><br />
Neuroimmunologia, Dipartimento <strong>di</strong> Neurologia e Fisiologia, San Raffaele, Milano<br />
Plasticità dei precursori neurali della regione subventricolare (SVZ) alla neurotossina MPTP:<br />
correlazione con la denervazione e reinnervazione nigrostriatale della SVZ.<br />
Serra Pier Andrea 1 , Migheli R. 1 , Rocchitta G. 1 , Bazzu G. 1 , Calia G. 1 , L‘Episcopo F. 3 ,<br />
Esposito G. 1 , Plachino S. 2 , Marchetti B. 1,3 , Miele E. 1<br />
1Dipartimento <strong>di</strong> Farmacologia, Ginecologia e Ostetricia, Sez. Farmacologia, Università <strong>di</strong> Sassari;<br />
2Dipartimento <strong>di</strong> Neuroscienze, Istituto scientifico San Raffaele, Milano; 3OASI (IRCCS) Istituto per la<br />
ricerca e la cura del ritardo mentale e dell’invecchiamento celebrale, Sez. Neurofarmacologia, Troina<br />
(EN)<br />
Il ciclo dell’acido ascorbico/acido deidroascorbico nelle cellule staminali provenienti dalla regione<br />
subventricolare del topo.<br />
pag_sx.indd 1 30/05/2007 2.43.27
Balduini Walter, Carloni S.<br />
Istituto <strong>di</strong> Farmacologia e Farmacognosia, Università <strong>di</strong> Urbino “Carlo Bo”<br />
Prolungato ruolo della morte cellulare <strong>di</strong> tipo necrotico dopo neurodegenerazione indotta da ipossiaischemia<br />
nel ratto neonato.<br />
Ferraro Luca 1 , Tomasini M.C. 1 , Fournier J. 2 , Mazza R. 1 , Manganelli S. 1 , Mazzoni E. 1 , Fuxe K. 3 ,<br />
Antonelli T. 1<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica e Sperimentale, Sezione <strong>di</strong> Farmacologia, Università <strong>di</strong><br />
Ferrara; 2 Sanofi-Aventis Recherche, Tolosa, Francia; 3 Dipartimento <strong>di</strong> Neuroscienze, Karolinska<br />
Institut, Stoccolma, Svezia<br />
Possibile ruolo dei recettori neurotensinergici nell’aumento dei livelli <strong>di</strong> glutammato e<br />
nell’apoptosi in seguito a deprivazione <strong>di</strong> ossigeno e glucosio in colture <strong>di</strong> neuroni corticali <strong>di</strong><br />
ratto.<br />
Gardoni Fabrizio, Marcello E., Epis R., Polli F., Malinverno M., Cattabeni F., Di Luca M.<br />
Dipartimento Scienze Farmacologiche – Università <strong>di</strong> Milano<br />
Nuovi targets <strong>di</strong> intervento farmacologico nella sinapsi eccitatoria glutammatergica.<br />
Moderatori: Nicoletti F (Roma) Tonon G (Cagliari)<br />
Battaglia Giuseppe 1 , Molinaro G. 1 , Riozzi B. 1 , Spinsanti P. 2 , Traficante A. 1 , Belluardo N. 3 ,<br />
Corti C. 4 , Nicoletti F. 1,2 , Bruno V. 1,2<br />
1 INM Neuromed, Pozzilli; 2 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, Università “La Sapienza”,<br />
Roma; 3 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Sperimentale, Università <strong>di</strong> Palermo; 4 Dipartimento <strong>di</strong> Biologia,<br />
GlaxoSmithKline, Verona<br />
La neuroprotezione me<strong>di</strong>ata dagli agonisti dei recettori metabotropici per il glutammato del II gruppo<br />
richiede la presenza dei recettori mGlu3 ed è me<strong>di</strong>ata dalla produzione <strong>di</strong> fattori neurotrofici.<br />
65<br />
Ferrari-Toninelli Giulia 1 , Bonini S.A. 1 , Uberti D. 1 , Zambrano N. 2 , Russo T. 2 , Memo M. 1<br />
1 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che e Biotecnologie, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Brescia; 2 CEINGE<br />
biotecnologie avanzate, Dipartimento <strong>di</strong> Biochimica e Biotecnologie Me<strong>di</strong>che, Università <strong>di</strong> Napoli<br />
Federico II<br />
La via del segnale <strong>di</strong> Notch come nuovo target farmacologico per la terapia delle neuropatie<br />
periferiche.<br />
Morrone Luigi A. 1 , Nucci C. 2,3 , Rombolà C. 1 , Cavaliere F. 1 , Cerulli A. 2 , Maccarrone M. 4 ,<br />
Corasaniti M.T. 3 , Bagetta G. 1<br />
1 Dipartimento Farmacobiologico, Università della Calabria; 2 Dipartimento <strong>di</strong> Biopatologia e Diagnostica<br />
per Immagini, Cattedra <strong>di</strong> Ottica Fisiopatologica, Università <strong>di</strong> Roma “Tor Vergata”; 3 IRCCS Istituto<br />
Neurologico Fondazione C. Mon<strong>di</strong>no, Centro <strong>di</strong> Neurofarmacologia Sperimentale Mon<strong>di</strong>no-Tor Vergata,<br />
Laboratorio <strong>di</strong> Neurochimica, Roma; 4 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Università <strong>di</strong> Teramo;<br />
5 Dipartimento <strong>di</strong> Scienze Farmacobiologiche, Università “Magna Graecia” <strong>di</strong> Catanzaro<br />
Ruolo del sistema endocannabinoide nei meccanismi alla base del danno retinico in un modello<br />
sperimentale <strong>di</strong> ischemia da aumentata pressione intraoculare nel ratto.<br />
Maullu Carlo 1 , Cabras C.A. 1 , Salis B. 1 , Onali P. 2 , Dedoni S. 2 , Marongiu C. 1 , Taylor G. 1 , Tonon<br />
G. 1<br />
1 Bio-Ker S.r.l., Pula (CA)<br />
2 Dipartimento <strong>di</strong> Neuroscienze BB Bro<strong>di</strong>e, Università <strong>di</strong> Cagliari<br />
Produzione <strong>di</strong> Interferone- (IFN- ) da E. coli e strategie per migliorare la bio<strong>di</strong>sponibilità e il profilo<br />
farmacologico.<br />
pag_dx.indd 1 30/05/2007 2.45.02
Cuzzocrea Salvatore 1,2 , Genovese T. 1,2 , Mazzon E. 1,2 , Crisafulli C. 1 , Di Paola R. 1,2 , Muià C. 1,2 ,<br />
Esposito E. 2,3 , Bramanti P. 2 , Zhang J. 4 , Caputi A.P. 1,2 , Wang Z-Q. 5<br />
1 Dipartimento Clinico Sperimentale e Farmacologia, Università <strong>di</strong> Messina; 2 IRCCS Centro Neurolesi<br />
"Bonino-Pulejo" Messina; 3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università Federico II Napoli;<br />
4 Guilford Pharmaceuticals Inc., Baltimore, USA; 5 International Agency for Research on Cancer, Lyon,<br />
France<br />
L’attività dell'enzima PARG me<strong>di</strong>a la risposta infiammatoria post-traumatica associata a trauma<br />
midollare.<br />
66<br />
Cre<strong>di</strong>ti ECM assegnati 4<br />
Corso <strong>di</strong> Aggiornamento<br />
Il trattamento a lungo termine della depressione: aspetti biologici<br />
e clinici<br />
Moderatori: Aguglia E (Trieste) Guazzelli M (Pisa)<br />
09.00/09.15 Aguglia E (Trieste)<br />
Apertura e introduzione<br />
09.15/10.00 Biggio G (Cagliari)<br />
Neurobiologia della remissione e reci<strong>di</strong>va dell'episo<strong>di</strong>o depressivo<br />
10.00/10.45 Torta R (<strong>Torino</strong>)<br />
La depressione fra psiche e soma: implicanze prognostiche e terapeutiche<br />
11.15/12.00 Mencacci C (Milano)<br />
Depressione: prevenzione delle ricorrenze<br />
12.00/12.30 Discussione<br />
SALA 4<br />
09.00-16.30<br />
12.30/13.00 Workshop<br />
Aguglia E (Trieste) Guazzelli M (Pisa) Mencacci C (Milano) Torta R (<strong>Torino</strong>)<br />
Presentazione dei casi clinici<br />
13.00/14.00 COLAZIONE DI LAVORO RISERVATA AI PARTECIPANTI<br />
14.00/16.00 Aguglia E (Trieste) Guazzelli M (Pisa) Mencacci C (Milano) Torta R (<strong>Torino</strong>)<br />
Elaborazione dei casi clinici<br />
16.00/16.30 Guazzelli M (Pisa)<br />
Conclusioni e questionario ECM<br />
Realizzato con il contributo educazionale <strong>di</strong> Wyeth<br />
Pausa caffè<br />
11.00-11.30<br />
pag_sx.indd 1 30/05/2007 2.55.01
Incontro con l'Esperto<br />
Update in <strong>di</strong>abetologia: gli inibitori del DPP-IV<br />
Moderatore: Carruba M (Milano)<br />
11.00/11.30 Mugelli A (Firenze)<br />
Il punto <strong>di</strong> vista del farmacologo<br />
11.30/12.00 Del Prato S (Pisa)<br />
Il punto <strong>di</strong> vista del <strong>di</strong>abetologo<br />
Sessione ECM<br />
SALA 3<br />
11.00-12.00<br />
Realizzato con il contributo educazionale <strong>di</strong> Novartis<br />
Compilazione Questionario ECM<br />
12.00-13.00<br />
Fine lavori del Congresso<br />
13.15<br />
67<br />
pag_dx.indd 1 30/05/2007 2.56.26
Senza titolo-3 1 28/05/2007 16.16.15
Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />
09.00/17.00 Corso <strong>di</strong><br />
Aggiornamento<br />
Il contributo della<br />
farmacologia al<br />
trattamento della<br />
depressione<br />
Mercoledì 6 giugno<br />
18.00/19.00 Cerimonia Inaugurale<br />
19.00/20.00 Lettura Inaugurale<br />
Three decades with three<br />
Swe<strong>di</strong>sh neuropeptides:<br />
focus on pain and<br />
depression<br />
20.00/22.00<br />
Cocktail <strong>di</strong> Benvenuto<br />
70<br />
pag_sx.indd 1 30/05/2007 3.35.00
Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />
Simposio<br />
Key research<br />
strategies in<br />
pharmacology:<br />
how to take<br />
water into dry<br />
pipe-lines<br />
Simposio<br />
Modulazione<br />
farmacologica<br />
dell'infiammazion<br />
e polmonare nella<br />
broncopneumopatia<br />
cronica<br />
ostruttiva<br />
Simposio<br />
Asma e patologie<br />
correlate<br />
Comunicazioni<br />
Orali<br />
Farmacologia<br />
delle sostanze<br />
d’abuso<br />
(08.30-11.30)<br />
Simposio<br />
Dalle scienze <strong>di</strong><br />
base alla scoperta<br />
<strong>di</strong> nuove terapie<br />
per l'epilessia<br />
Simposio<br />
<strong>SIF</strong> e informazione<br />
in<strong>di</strong>pendente sul<br />
farmaco<br />
Simposio<br />
Efficacia e sicurezza <strong>di</strong><br />
FANS tra<strong>di</strong>zionali e<br />
COXIB<br />
Simposio<br />
Modulazione<br />
farmacologica dei<br />
recettori P1<br />
08.30/11.00 Simposio<br />
Vecchi e nuovi<br />
antipsicotici a<br />
confronto<br />
11.00/11.30 Pausa caffè<br />
11.30/12.30 Lettura Plenaria<br />
Ruolo funzionale della<br />
neurogenesi nell'adulto<br />
12.30/13.30 Colazione <strong>di</strong> lavoro<br />
12.30/15.00 Sessione Poster<br />
Incontro con<br />
l'esperto<br />
Ricerca e sviluppo<br />
in antibioticoterapia:<br />
a che<br />
punto siamo?<br />
14.00/15.00 Incontro con<br />
l'esperto<br />
La vareniclina:<br />
nuove prospettive<br />
nella terapia del<br />
tabagismo<br />
Simposio<br />
Farmacoutilizzazione<br />
e<br />
appropriatezza<br />
d'uso dei farmaci<br />
Simposio<br />
La formazione<br />
specialistica in<br />
farmacologia<br />
Simposio<br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> sicurezza<br />
dei me<strong>di</strong>cinali<br />
biologici (anticorpi<br />
monoclonali)<br />
Tavola Rotonda<br />
Farmacologia <strong>di</strong><br />
genere: dal<br />
laboratorio alla<br />
società<br />
Simposio<br />
Infiammazioni e<br />
sindromi<br />
coronariche<br />
acute: stato<br />
dell'arte<br />
Simposio<br />
Nuove prospettive<br />
terapeutiche nel<br />
trattamento della<br />
depressione.<br />
L'approccio<br />
melatoninergico:<br />
dalla farmacologia<br />
all'evidenza clinica<br />
Comunicazioni Orali<br />
Giovani Farmacologi<br />
(15.00-20.00)<br />
Simposio<br />
Modulazione<br />
farmacologica dei<br />
recettori P2<br />
15.00/17.30 Simposio<br />
Nuove acquisizioni<br />
nella ricerca sui<br />
cannabinoi<strong>di</strong><br />
Simposio<br />
La malattia <strong>di</strong><br />
Parkinson: dalla<br />
biologia<br />
molecolare alla<br />
terapia<br />
Simposio<br />
Canali ionici<br />
come bersagli<br />
terapeutici per<br />
malattie<br />
genetiche e<br />
non-genetiche<br />
Simposio<br />
Meccanismi<br />
farmacologici che<br />
regolano la<br />
proliferazione e il<br />
<strong>di</strong>fferenziamento<br />
delle cellule<br />
staminali<br />
Simposio<br />
Targets cellulari e<br />
molecolari per lo<br />
sviluppo <strong>di</strong> nuove<br />
terapie in corso <strong>di</strong><br />
neuroAIDS<br />
Comunicazioni<br />
Orali<br />
Farmacologia del<br />
dolore e<br />
infiammazione<br />
Simposio<br />
Farmaci inibitori<br />
della pompa<br />
protonica e danno<br />
<strong>di</strong>gestivo indotto da<br />
FANS: aspetti<br />
farmacologici e<br />
clinici<br />
Simposio<br />
La neurobiologia e i<br />
trattamenti<br />
farmacologici del<br />
poliabuso<br />
17.30/19.30 Simposio<br />
Nuovi aspetti<br />
patogenetici e<br />
terapeutici della<br />
neurodegenerazione<br />
71<br />
Giovedì 7 giugno<br />
pag_dx.indd 1 27/05/2007 18.55.12
Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />
Simposio<br />
Farmacifarmacistifarmacie<br />
Simposio<br />
Meccanismi<br />
d'azione <strong>degli</strong><br />
antidepressivi:<br />
nuove acquisizioni<br />
Simposio<br />
I nuovi farmaci<br />
target-specifici in<br />
oncologia<br />
Simposio<br />
Sistema nervososistema<br />
immunitario tra<br />
interazione e<br />
integrazione:<br />
tempo per la<br />
neuro-immunofarmacologia?<br />
Simposio<br />
Nocicettina/<br />
orfanina FQ: dagli<br />
stu<strong>di</strong> <strong>di</strong> base alla<br />
clinica<br />
Comunicazioni<br />
Orali<br />
Farmacologia<br />
Car<strong>di</strong>ovascolare<br />
(08.30/11.30)<br />
Simposio<br />
Farmacologia dei<br />
recettori TRPV1<br />
(vanilloi<strong>di</strong>) nel sistema<br />
nervoso centrale e<br />
periferico<br />
Tavola Rotonda<br />
La prima del farmaco<br />
sull'uomo<br />
08.30/11.00 Simposio<br />
La cascata della via<br />
WNT come target delle<br />
patologie<br />
neurodegenerative<br />
Comunicazioni<br />
(09.50-11.00)<br />
11.00/13.00 Sessione Plenaria<br />
La ricerca clinica in<br />
Italia: attualità e<br />
prospettive<br />
12.30/17.30 Simposio<br />
Appropriatezza<br />
nella terapia<br />
farmacologica<br />
car<strong>di</strong>ovascolare<br />
Incontro con<br />
l'esperto<br />
Inibizione della<br />
corrente pacemaker<br />
IF:<br />
dall'elettrofisiologia<br />
alla pratica clinica<br />
Comunicazioni<br />
Orali<br />
Farmacologia<br />
car<strong>di</strong>ovascolare<br />
Venerdì 8 giugno<br />
13.00/14.00 Colazione <strong>di</strong> lavoro<br />
13.00/15.00 Sessione Poster<br />
Simposio<br />
I modelli animali<br />
nella ricerca<br />
biome<strong>di</strong>ca<br />
Comunicazioni<br />
Orali<br />
Farmaci<br />
antitumorali<br />
Comunicazioni<br />
Orali<br />
Nuove<br />
acquisizioni sulla<br />
Farmacologia <strong>di</strong><br />
Genere<br />
Simposio<br />
Atomoxetina,<br />
nuova alternativa<br />
terapeutica per il<br />
trattamento del<br />
<strong>di</strong>sturbo da deficit<br />
dell'attenzione e<br />
iperattività<br />
(ADHD)<br />
Simposio<br />
Lo stress nella<br />
patologia mentale:<br />
comportamento,<br />
neurobiologia e<br />
trattamento<br />
Simposio<br />
Angiogenesi tumorale<br />
e terapia<br />
antiangiogenica<br />
15.00/17.30 Simposio<br />
Glucocorticoi<strong>di</strong>,<br />
meccanismi molecolari<br />
ed efficacia<br />
antinfiammatoria ed<br />
immunosoppressiva<br />
17.30/19.30 Assemblea dei Soci<br />
72<br />
pag_sx.indd 1 27/05/2007 18.58.01
Au<strong>di</strong>torium Sala 1 Sala 2 Sala 3 Sala 4 Sala 5 Sala 6 Sala 7 Sala 8<br />
Simposio<br />
Monossido <strong>di</strong> azoto<br />
(NO) ed infiammazione:<br />
prospettive<br />
terapeutiche<br />
Simposio<br />
Basi<br />
farmacocinetiche/<br />
farmaco<strong>di</strong>namiche<br />
(PK/PD) per il<br />
corretto uso dei<br />
farmaci<br />
antimicrobici<br />
Simposio<br />
Aspetti cellulari e<br />
molecolari del<br />
precon<strong>di</strong>zionamento<br />
e<br />
postcon<strong>di</strong>zionamento<br />
ischemico: basi <strong>di</strong><br />
intervento<br />
farmacologico<br />
Simposio<br />
Terapia<br />
ormonale<br />
sostitutiva: se,<br />
quando, per<br />
quanto e<br />
perchè<br />
Comunicazioni Orali<br />
Farmacologia <strong>di</strong><br />
Scienze<br />
(08.30-12.15)<br />
08.30/11.00 Simposio<br />
Target molecolari<br />
del dolore cronico<br />
09.00/16.30 Corso <strong>di</strong><br />
Aggiornamento<br />
Il trattamento a<br />
lungo termine<br />
della<br />
depressione:<br />
aspetti biologici e<br />
clinici<br />
11.00/13.00 Comunicazioni<br />
Orali<br />
Neurodegenerazione<br />
e<br />
neuroprotezione<br />
11.00/11.30 Pausa caffè<br />
11.00/12.00 Lettura<br />
Plenaria<br />
Update in<br />
<strong>di</strong>abetologia:<br />
gli inibitori del<br />
DPP-IV<br />
73<br />
Sabato 9 giugno<br />
pag_dx.indd 1 30/05/2007 3.39.02
pag_sx.indd 1 28/05/2007 22.17.19
Sessione Poster<br />
Recettori e meccanismi <strong>di</strong> trasduzione del segnale<br />
Poster 1-20<br />
12.30-15.00<br />
1. Coupling of cannabinoid receptors to intracellular calcium mobilization in rat<br />
insulinoma B-cells<br />
Marini Pietro 1 , De Petrocellis L. 2 , Matias I. 2 , Schiano Moriello A. 2,3 , Starowicz K 3 , Cristino L. 2 ,<br />
Di Marzo V. 3<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />
Rome, Italy 2,3 Endocannabinoid Research Group, 2 Institute of Cybernetics and 3 Institute of<br />
Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio<br />
Olivetti, 80078, Pozzuoli, Naples, Italy<br />
2. Different striatal C-FOS expression following co-administration of delta-9-<br />
tetrahydrocannabinol with haloperidol or clozapine<br />
Casti Paola, a Marchese G. a , Sanna A. a , Casu G. a , Pinna Spada G. a , Pani L. a,b<br />
a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />
(CA), Italy. b C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o Neuroscienze<br />
PharmaNess S.c.a r.l.<br />
76<br />
3. Altered endocannabinoid-me<strong>di</strong>ated synaptic plasticity in hippocampal neurons in<br />
obesity<br />
1 Massa Federico, 1,2 Mancini G., 2 Pagotto U., 1 Lutz Beat<br />
1 Department of Physiological Chemistry, Johannes Gutenberg University, Mainz, Germany.<br />
2 Endocrinology Unit, Department of Internal Me<strong>di</strong>cine and Gastroenterology, S. Orsola-<br />
Malpighi General Hospital, Alma Mater University of Bologna, Bologna, Italy<br />
4. Caveolae/lipid rafts control signaling of CB1 cannabinoid receptor in human breast<br />
cancer cells<br />
Grimal<strong>di</strong> Clau<strong>di</strong>a, Sarnataro D., Cavallo P., Capasso A., Bifulco M.<br />
Department of Pharmaceutical Sciences, University of Salerno, Fisciano, Italy<br />
5. Pharmacological characterization of single nucleotide polymorphisms for human CB2<br />
receptor<br />
Petrò Roberta, Beltramo M., Brusa R., Downey P., Jason S., Foglia C., Scandroglio P.,<br />
Reggiani A.<br />
Schering Plough Research Institute, Via Olgettina 58, 20132 Milano, Italy<br />
6. RITIRATO<br />
7. Lithium regulates neuronal excitability in rat hippocampus<br />
Murru Luca, Carta M., Pitzianti S., Corda G., Sanna E., Biggio G.<br />
Dept. Experimental Biology, Sect of Neuroscience, and Center of Excellence for the<br />
Neurobiology of Dependence. Cittadella Universitaria, SS 554 Km 4,500, 09042, Monserrato,<br />
Cagliari, Italy<br />
8. Thiocolchicoside inhibits the activity of various subtypes of recembinant GABA A<br />
receptors expressed in Xenoups Laevis oocyte<br />
Mascia Maria Paola a , Bachis E. b , Obili N. b , Maciocco E. a , Cocco G. A c , Sechi G.P. c , Biggio G. a,b<br />
a National Research Council, Institute of Neuroscience, Cagliari, Italy; b Department of<br />
Experimental Biology “B. Loddo”, University of Cagliari, Cagliari, Italy; c Neurological Clinic ,<br />
University of Sassari, Sassari, Italy<br />
pag_sx.indd 1 30/05/2007 3.45.04
9. Direct modulation of gabaergic transmission by thyroid hormones (THs) in<br />
hippocampus<br />
Losi Gabriele, Puia G.<br />
Dept. Biome<strong>di</strong>cal Science, University of Modena and Reggio Emilia, via Campi 287, Modena,<br />
ITALY<br />
10. Pregnancy and delivery change the gene expression of synaptic and extrasynaptic<br />
GABA A receptors in the rat hippocampus<br />
Mura Maria Luisa 1 , Mostallino M.C. 2 , Maciocco E. 2 , Biggio G. 1,2,3<br />
1 Departement of Experimental Biology, Section of Neuroscience, University of Cagliari,<br />
Monserrato (Cagliari), Italy; 2 CNR, Institute of Neuroscienze, Monserrato (Cagliari), Italy;<br />
3 Center of Excellence for the “Neurobiology of Drug Dependence”, University of Cagliari,<br />
Monserrato (Cagliari) Italy<br />
11. Plasticity of the gabaergic transmission in the rat hippocampus during pregnancy<br />
Murru Luca, Talani G., Serra V., Carta M., Sitzia F., Uras R., Sanna E., Biggio G.<br />
Dept. Experimental Biology, Sect of Neuroscience, and Center of Excellence for the<br />
Neurobiology of Dependence. Cittadella Universitaria, SS 554 Km 4,500, 09042, Monserrato,<br />
Cagliari, Italy<br />
12. Activation of group II metabotropic glutamate receptors prevents the <strong>di</strong>fferentiation<br />
of cultured neural progenitor cells isolated from the mouse subventricular zone into<br />
mature astrocytes<br />
Ciceroni Cinzia 1 , Mosillo P. 1 , Mastrantoni E. 1 , Magnotti M. C. 1 , Cappuccio I. 1,3 , Lupieri T. 1 ,<br />
Nicoletti F. 1,2 , Melchiorri D. 1<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />
Rome; 2 I.N.M. Neuromed, Pozzilli, Italy; 3 I.R.C.C.S. San Raffaele, Rome<br />
77<br />
13. In<strong>di</strong>vidual subtypes of metabotropic glutamate receptors regulates neural<br />
<strong>di</strong>fferentiation of cultured mouse embryonic stem cells<br />
Cappuccio Irene 1,2* , Sarichelou I. 1* , Costantino S. 1 , Ferranti F. 1 , Niccolini C. 1 , Nicoletti F. 1,3 ,<br />
Melchiorri D. 1<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />
Rome; 2 I.R.C.C.S. San Raffaele, Roma, 3 I.N.M. Neuromed, Pozzilli, Italy<br />
14. The human immunodeficiency virus-1 protein (TAT) modulates NMDA receptor<br />
function by acting at colocalized metabotropic glutamate receptor 1<br />
Musante Veronica 1 , Neri E. 1 , Severi P. 2 , Raiteri M. 1,3 , Pittaluga A. 1,3<br />
1 DI.ME.S, Pharmacology and Toxicology Section, Department of Experimental Me<strong>di</strong>cine,<br />
University of Genova, Italy, 2 Dision of Neurosurgery, Galliera Hospital, Genova, Italy, 3 Center<br />
of Excellence for Biome<strong>di</strong>cal Research, University of Genova, Italy<br />
15. Colocalization and functional interactions between presinaptic AMPA; NMDA and<br />
group I metabotropic glutamate receptors<br />
Neri Elisa, Musante V., Severi P., Pittaluga A., Raiteri M.<br />
1 DI.ME.S, Pharmacology and Toxicology Section, Department of Experimental Me<strong>di</strong>cine,<br />
University of Genova, Genova Italy; 2 Division of Neurosurgery, Galliera Hospital, Genova,<br />
Italy; 3 Center of Excellence for Biome<strong>di</strong>cal Research, University of Genova, Genova Italy<br />
16. Co-expression of metabotropic glutamate 1A (mGlu1A) receptor and cannabinoid 1<br />
(CB1) receptor immunoreactivity in the rat hippocampus<br />
Boscia Francesca, *Moroni F., Annunziato L. *Pellegrini-G. D.<br />
Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> Napoli “Federico II”<br />
*Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze<br />
pag_dx.indd 1 30/05/2007 3.49.33
17. Biochemical and pharmacological evidences for (-)-epigallo catechin-3-gallate<br />
(EGCG) to link NMDA receptors in rat cortex<br />
Lograno Marco D., Romano M.R.<br />
Department of Pharmacobiology, University of Bari, Via E. Orabona, 4, 70125 Bari, Italy<br />
18. Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist<br />
sb-612111: in vitro stu<strong>di</strong>es<br />
1 Fischetti Carmela, 1 Spagnolo B., 1 Carra’ G., 1 Fantin M., 2 Hebbes C., 2 McDonald J., 2 Barnes A.<br />
1 Rizzi A., 1 Marzola G., 3 Trapella C., 3 Fanton G., 1 Morari M., 2 Lambert D., 1 Regoli D., 1 Calo’ G.<br />
1 Dept. of Pharmacology and 3 Dept of Pharmaceutical Science, University of Ferrara, Italy.<br />
2 Dept. of Car<strong>di</strong>ovascular Sciences, University of Leicester, UK<br />
19. Activation of nociceptin/orphanin FQ and classical opioid receptors in CHO cells<br />
expressing the CHIMERIC Galpha qi5 protein promotes calcium mobilization<br />
Camarda Valeria 1 , Molinari P. 2 , Ambrosio C. 2 , Kostenis E. 3 , Regoli D. 1 , Guerrini R. 4 , Salvatori<br />
S. 4 , Calo’ G. 1<br />
1 Dept Exp and Clin Me<strong>di</strong>cine, Section of Pharmacology, University of Ferrara, Italy;<br />
2 Dept of Pharmacology, ISS, Rome, Italy; 3: Inst for Pharmaceutical Biology, Bonn, Germany;<br />
4: Dept of Pharmaceutical Sciences, University of Ferrara, Italy<br />
78<br />
20. Opposite effects on cell proliferation by wnt1 AND wNT7a proteins in cultured pc12<br />
cells<br />
De Vita Teresa 1 , Spinsanti P. 1 , Caruso A. 1 , Lisi I. 1 , Melchiorri D. 1 , Caricasole A. 2 , Nicoletti F. 1,3<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”;<br />
2 Sienabiotech S.p.A., Siena; and 3I.N.M. Neuromed, Pozzilli, Italy<br />
Controllo farmacologico dei processi <strong>di</strong> morte e proliferazione cellulare<br />
Poster 21 – 42<br />
21. Role of NO/Ca 2+ /CaM/MAPK signalling pathway in the mitogenic effect of IL-1 in<br />
C6 glioma cells<br />
Sticozzi Clau<strong>di</strong>a, Meini A., Palmi M.<br />
Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena, via Aldo Moro, 2 Siena<br />
22. Neurogenic response induced by fluoxetine chronic treatment in neural progenitor<br />
cells isolated from rat postnatal cerebellum<br />
Zusso Morena, Debetto P., Barbierato M., Guidolin D.*, Giusti P.<br />
Department of Pharmacology and Anestesiology, University of Padova, Italy<br />
*Department of Anatomy and Physiology, University of Padova, Italy<br />
23. Involvement of cannabinoid system in proliferation of cerebellar neural progenitor<br />
cells<br />
Soffia Silvia, Corso M., Barbierato M., Giusti P., Debetto P., Zusso M.<br />
Department of Pharmacology and Anesthesiology “E. Meneghetti”, University of Padova, Italy<br />
24. Effect of oxysterols on cell survival and proliferation pathways in human endothelial<br />
cells<br />
Agnoletto Laura, Poggiani C., Cusinato F., Trevisi L., Luciani S.<br />
Department of Pharmacology and Anaesthesiology, University of Padova<br />
pag_sx.indd 1 30/05/2007 3.50.45
25. Expression of CXCR4 and SDF1/CXCL12 in human normal pituitary and pituitary<br />
adenoma tissues: role in cell proliferation<br />
Florio Tullio, Barbieri F., Bajetto A., Porcile C., Pattarozzi A.,Gatti M., Corsaro A., Thellung S.,<br />
Villa V., Schettini G.<br />
Section of Pharmacology, Department of Oncology, Biology and Genetics, University of<br />
Genova, Italy<br />
26. Dopamine and L-DOPA increase in vitro proliferation of stem cells from the mouse<br />
subventricular zone<br />
Serra Pier Andrea a , Migheli R.,Rocchitta G., Calia G., Dedola S., Manca A. a , L‘Episcopo<br />
F. c , Pluchino S. b , Marchetti B. a,c , Desole M.S. a<br />
a Department of Pharmacology, University of Sassari, 07100 Sassari, Italy<br />
b Department of Neuroscience, S. Raffaele Scientific Institute, Milano,<br />
Italy<br />
c OASI Institute for Research and Care on Mental Retardation and Brain Aging<br />
(IRCCS), Neuropharmacology Section, Troina, Italy<br />
27. Antiproliferative effects of pyrazolo-pyrimi<strong>di</strong>ne -type inhibitors of SRC family<br />
tyrosine kinases derivates on human neuroblastoma cells<br />
Navarra Michele 1 , Celano M. 2 , Schenone S. 3 , Botta M. 4 , Bramanti P. 5 , Russo D. 2<br />
1 Pharmaco-Biological Department, University of Messina, 2 Department of Pharmacobiological<br />
Sciences, University "Magna Græcia" of Catanzaro, 2 Department of Pharmaceutical Sciences,<br />
University of Genova, 4 Department of Pure and Applied Me<strong>di</strong>cinal Chemistry, University of<br />
Siena, 5 IRCCS centro neurolesi “Bonino-Pulejo”<br />
28. Neuron-like cells derived from bone marrow stromal cells: expression and<br />
functioning of GABA B receptors<br />
Cervetto Chiara 1 , Paluzzi P. 1 , Guarnieri S. 1 , Marcoli M. 1 , Castagnola P. 2 , Tonachini L. 2 ,<br />
Mastrogiacomo M. 2 , Monticone M. 2 , Pestarino M. 3 , Can<strong>di</strong>ani S. 3 , Maura G. 1*<br />
1 Dep. Experimental Me<strong>di</strong>cine, 3 Dep. Biology, * Centre of Excellence for Biome<strong>di</strong>cal Research,<br />
University of Genova and 2 Ist Naz Ricerca sul Cancro, Genova, Italy<br />
79<br />
29. Influence of leptin on the early phases of bone formation during mouse skeleton<br />
organogenesis<br />
1 Rivasi Marianna, 1 Benelli A., 2 Ferretti M., 2 Benincasa M., 2 Bertoni L., 2 Cavani F., 2 Palumbo C.<br />
1 Dept. of Biome<strong>di</strong>cal Sciences, Section of Pharmacology; 2 Dept. of Anatomy and Istology,<br />
Section of Human Anatomy; University of Modena and Reggio Emilia, Modena, Italy<br />
30. Proliferation and invasiveness of human smooth muscle TSC2-/- cells. Effect of anti-<br />
EGFR and rapamycin<br />
Di Giulio Anna Maria, Isaia E., Grande V., Lesma E., Gorio A.<br />
Pharmacological Laboratories, Dept. of Me<strong>di</strong>cine, Surgery and Dentistry, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />
<strong>di</strong> Milano<br />
31. Reversion of the phenotype of human TSC2 -/- smooth muscle cells. Novel insights for<br />
TSC and LAM therapy<br />
Lesma Elena, Grande V., Isaia E., Di Giulio A. M., Gorio A.<br />
Pharmacological Laboratories, Dept. of Me<strong>di</strong>cine, Surgery and Dentistry, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />
<strong>di</strong> Milano<br />
32. Expression of Annexin A1 in mouse myoblast <strong>di</strong>fferentiation cell line<br />
Bizzarro Valentina, Festa M., Ercolino S.F., Franceschelli S., Solito E.*, Parente L., Putrella A.<br />
Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy<br />
*Department of Cellular and Molecular Neuroscience, Faculty of Me<strong>di</strong>cine, Imperial College,<br />
London, UK<br />
pag_dx.indd 1 30/05/2007 3.51.35
33. The glucocorticoid-induced leucine zipper (Gilz) inhibits skeletal myogenesis by<br />
counteracting myod activity<br />
Donato Valerio 1 , Velar<strong>di</strong> E. 1 , Bruscoli S. 1 , Bastianelli A. 1 , Donato R. 2 , Riccar<strong>di</strong> C. 1<br />
1 Dept. Clinical and Experimental Me<strong>di</strong>cine, Sect. Pharmacology, and 2 Dept. Experimental<br />
Me<strong>di</strong>cine and Biochemical Sciences, Sect. Anatomy, Perugia University Me<strong>di</strong>cal School,<br />
06122, Perugia, Italy<br />
34. Calixarene glycoconjugates inhibit c6 glioma cell proliferation and migration:<br />
interaction with growth factors<br />
Viola Santa 1 , Consoli Grazia M.L. 2 , Merlo S. 1 , Geraci C. 2 , Sortino M. A. 1<br />
1 Department of Experimental and Clinical Pharmacology, University of Catania and 2 Institute<br />
of Biomolecular Chemistry, CNR, Valverde, Catania<br />
35. Cannabinoids inhibit human colon cancer cell proliferation through CB 2 -receptor and<br />
ceramide pathway activation<br />
Mastroianni Rosanna a , Cianchi F. b , Magnelli L. c , Schiavone N. c , Perna F. b , Capaccioli S. c ,<br />
Manera C. d , Mannaioni P.F., Masini E. a<br />
a Department of Preclinical and Clinical Pharmacology, b Department of Critical Care Me<strong>di</strong>cine<br />
and c Department Pathology and Experimental Oncology, University of Florence, Florence,<br />
Italy; d Department of Pharmaceutical Sciences, University of Pisa, Pisa, Italy<br />
80<br />
36. Role of Lox pathway and endocannabinoid system in antitumor activity of<br />
Cannabi<strong>di</strong>ol, a non-psychoactive cannabinoid<br />
Valenti Marta 2 , Massi P. 1 , Gasperi M. 3 , Meli S. 2 , Maccarrone M. 3 Parolaro D. 2<br />
1 Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via<br />
Vanvitelli 32, Milan, Italy<br />
2 Department of Structural and Functional Biology, Pharmacology Section, Center of<br />
Neuroscience, University of Insubria, Via A. da Giussano 10, Busto Arsizio (VA), Italy<br />
3 Department of Biome<strong>di</strong>cal Sciences, University of Teramo, 64100 Teramo, Italy<br />
37. Effects of the IL-6 receptor superantagonist SANT7 on TGF-B-induced cell<br />
proliferation and MAP kinase phosphorylation in primary cultures of fibrotic human<br />
lung fibroblasts<br />
Gallelli Luca, Falcone D., Renda T., Pelaia G.o, Maselli R., Savino R., De Sarro G.<br />
Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine, University Magna<br />
Graecia of Catanzaro, Italy<br />
38. Effects of simvastatin and betamethasone on hydrogen peroxide induced MAPK<br />
activation, IL-8 production and cell proliferation in primary cultures of human<br />
squamous lung cancer cells<br />
Fratto Donatella 1 , Gallelli L. 1 , Renda T. 1 , Pelaia G. 2 , Maselli R. 2 , De Sarro G. 1<br />
1 Chair of Pharmacology, and 2 Chair of Respiratory Diseases, Department of Experimental and<br />
Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Italy<br />
39. PKC isoenzyme is involved in growth and angiogenesis of prostate cancer<br />
Betti Niccolò 1 , Morbidelli L. 1 , Corti F. 2 , Mochly-Rosen D. 3 , Ziche M. 1<br />
1 Pharmacology section, Dept Molecular Biology, University of Siena. 2 Proteomic section, Dept<br />
Molecular Biology, University of Siena. 3 Molecular pharmacology, School of Me<strong>di</strong>cine,<br />
Stanford University<br />
pag_sx.indd 1 30/05/2007 3.52.27
40. Tumor necrosis factor related apoptosis inducing ligand inhibits angiogenesis<br />
stimulated by human glioblastoma cells<br />
Scuderi Mariagrazia Rita, Albini A. 1 , Lempereur L., Pennisi G. 2 , Bernar<strong>di</strong>ni R., Cantarella G.<br />
Department of Experimental and Clinical Pharmacology; and Department of Chemical<br />
Sciences; University of Catania, 95100 Catania, Italy; Laboratory of Molecular Oncology,<br />
Istituto Tumori, 16100 Genova, Italy<br />
41. Antiangiogenic and antitumour effects of metronomic irinotecan (CPT-11)<br />
Fioravanti Anna 1 , Orlan<strong>di</strong> P. 1 , Falcone A. 2 , Danesi R. 1 , Del Tacca M. 1 , Bocci G. 1<br />
1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />
Pisa, 2 Oncology Unit; General Hospital, Livorno<br />
42. Natural and semisynthetic antraquinones, flavonoids and naphtoquinones effects on<br />
cell cycle in human ovarian cancer<br />
Montopoli M., Moro S.*, Cozza G.*, Zagotto G. *, Frol<strong>di</strong> G., Ragazzi E., Caparrotta L.<br />
Department of Pharmacology and Anaestesiology, University of Padova Largo E. Meneghetti 2,<br />
35131 Padova, Italy. * Department of Pharmaceutical Sciences, University of Padova, Via<br />
Marzolo 5, 35131 Padova, Italy<br />
Farmacologia della trasmissione sinaptica<br />
Poster 43 – 55<br />
43. SNAP-25 Phosphorylation on Serin 187 me<strong>di</strong>ates negative modulation of neuronal<br />
calcium dynamics<br />
Pozzi Davide 1 , Condliffe S. 1 , Grumelli C. 1 , Bozzi J. 2 , Caleo M. 2 , Proux-Gillardeaux V. 3 ,<br />
Takahashi M. 4 , Verderio C. 1 , Matteoli M. 1<br />
1 Department of Me<strong>di</strong>cal Pharmacology and CNR Institute of Neuroscience, Center of<br />
Excellence for Neurodegenerative Diseases, University of Milano, Via Vanvitelli 32, 20129<br />
Milano, Italy. 2 CNR- Institute of Neuroscience via G. Moruzzi 1, 56100 Pisa, Italy. 3 Institut<br />
Jacques Monod UMR7592 Tour 43 2ème étage 2, place Jussieu, F-75251 Paris Cedex 05,<br />
France. 4 Department of Biochemistry, Kitasato University School of Me<strong>di</strong>cine, Kitasato 1-15-1,<br />
Sagamihara-shi, Kanagawa 228-8555, Japan<br />
81<br />
44. Selective regulation of [ 3 H]D-aspartate release from hyppocampal nerve en<strong>di</strong>ngs by<br />
large-conductance Ca 2+ - and voltage-activated K + (BK) channels<br />
Martire Maria 1 , D’Amico M. 1 , Calciano S. 1 , Panza E. 2 , Iannotti F. 2,3 , Barrese V. 2 , Preziosi P. 1 ,<br />
Annunziato L. 2 , Tagliatatela M. 2,3<br />
1 Inst. of Pharmacology, Catholic University of S. Heart, Rome; 2 Division of Pharmacology,<br />
Dept. of Neuroscience, University of Naples Federico II, Naples; 3 Dept. of Health Science,<br />
University of Molise, Campobasso; Italy<br />
45. KCNQ channels regulate depolarization-induced changes in intracellular Ca 2+<br />
concentrations in rat cerebrocortical nerve en<strong>di</strong>ngs<br />
1 Luisi Rosa, 1 Panza E., 1 Secondo A., 2 Martire M., 1 Annunziato L., 1,3 Maurizio Taglialatela M.<br />
1 Div. of Pharmacology, Dept. of Neuroscience, School of Me<strong>di</strong>cine, Univ. “Federico II”, Naples;<br />
2 Insitute of Pharmacology, School of Me<strong>di</strong>cine, Catholic Univ. of Sacred Heart, Rome; 3 Dept.<br />
of Health Sciences, Univ. of Molise, Campobasso, Italy<br />
46. Adult astroglia is competent for Na + /Ca 2+ exchanger-operated exocytotic glutamate<br />
release triggered by mild depolarization<br />
1 Zappettini Simona, 2 Alloisio S., 1 Raiteri L., 1 Paluzzi S., 2 Nobile M., 1 Bonanno G.<br />
1 Department of Experimental Me<strong>di</strong>cine - Pharmacology and Toxicology Section and Center of<br />
Excellence for Biome<strong>di</strong>cal Research, University of Genoa, Italy. 2 Institute of Biophysics,<br />
National Research Council, Genoa, Italy<br />
pag_dx.indd 1 30/05/2007 3.53.40
47. Mechanisms of [ 3 H]glycine release from mouse spinal cord synaptosomes selectively<br />
labelled through glyt2 transporters<br />
Luccini Elisa, Raiteri L.<br />
Department of Experimental Me<strong>di</strong>cine, Pharmacology and Toxicology Section, University of<br />
Genoa<br />
48. Importance of protein kinase C epsilon for the allosteric modulation of GABA evoked<br />
currents in cortical culture at <strong>di</strong>fferent DIV<br />
Garzon Giorgio, Baral<strong>di</strong> M., Puja G.<br />
Dept. of BioMe<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Via G. Campi 287,<br />
41100 Modena, Italy<br />
49. 7 nicotinic receptor present on mouse cortical astrocytes modulates endogenoous<br />
glutamate release<br />
Patti Laura 1 , Raiteri L. 1 , Grilli M. 1 , Robino F. 1 , Zappettini S. 1 , Bonanno G.B. 1,2 , Marchi M. 1,2<br />
1 Section of Pharmacology and Toxicology, Department of Experimental Me<strong>di</strong>cine, University of<br />
Genoa, Italy. 2 Center of Excellence for Biome<strong>di</strong>cal Research, University of Genoa, Italy<br />
50. The agonist of metabotropic glutamate 5 receptors CHPG inverts the effects of DHK<br />
(a blocker of glial glutamate uptake): an in vivo microdyalisis study<br />
Armida Monica, Pintor A., Pèzzola A., Popoli P.<br />
Department of Therapeutic Research and Me<strong>di</strong>cines Evaluation, Istituto Superiore <strong>di</strong> Sanità,<br />
Roma (Italy)<br />
82<br />
51. The metabotropic glutamate 5 (mGlu5Rs) and the adenosine A 2A receptors (A 2A Rs)<br />
oppositely modulate CB1-induced reduction of synaptic transmission in the rat<br />
striatum<br />
Martire Alberto, Tebano M.T., Domenici M.R., Popoli P.<br />
Department of Therapeutic Research and Me<strong>di</strong>cines Evaluation, Istituto Superiore <strong>di</strong> Sanità,<br />
Roma (Italy)<br />
52. Glutamate release induced by activation of GAT-1 transporters sited on glutamate<br />
releasing spinal cord gliosomes and its augmentation in a mouse model of<br />
amyotrophic lateral sclerosis<br />
1 Milanese Marco, Raiteri L., 1 Zappettini S., 2 Usai C., 1 Bonanno G.<br />
1 Department of Experimental Me<strong>di</strong>cine - Pharmacology and Toxicology Section and Center of<br />
Excellence for Biome<strong>di</strong>cal Research, University of Genoa, Italy. 2 Institute of Biophysics,<br />
National Research Council, Genoa, Italy<br />
53. Thyroid hormones modulate glutamatergic neurotransmission in hippocampus<br />
Puja Giulia, Losi G., Garzon G., Baral<strong>di</strong> M.<br />
Dept. of BioMe<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Via G. Campi 287,<br />
41100 Modena, Italy<br />
54. Role of ionotropic glutamatergic receptors in the regulation of hippocampal<br />
norepinephrine ouput in vivo<br />
Matzeu Alessandra, Dazzi L., Biggio G.<br />
Department of Experimental Biology, Neuroscience section, University of Cagliari, Cagliari,<br />
Italy<br />
55. Alterations of glutamatergic transmission in a murine model of multiple sclerosis:<br />
preliminary results<br />
Pepicelli Olimpia a , Marte A. a , Uccelli A. c , Mancar<strong>di</strong> L. c , Raiteri M. a,b , Fedele E. a,b<br />
a Dept. of Experimental Me<strong>di</strong>cine, Pharmacology and Toxicology Section, University of Genoa;<br />
b Centre of Excellence for Biome<strong>di</strong>cal Research, University of Genoa; c Dept. of Neurosciences,<br />
Ophthalmology and Genetics, University of Genoa, Italy<br />
pag_sx.indd 1 30/05/2007 3.54.37
Farmacologia car<strong>di</strong>ovascolare<br />
Poster 56 – 70<br />
56. Mo<strong>di</strong>fication of pressure and placental protein expression in pregnant spontaneously<br />
hypertensive rats (SHR)<br />
1 Bianco Giuseppe, Iacono A., Esposito E., Mattace Raso G., 1 Autore G., Meli R.<br />
Department of Experimental Pharmacology, University of Naples “Federico II”, Naples,<br />
1 Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy<br />
57. Increased p22phox expression and reduced SOD activity are involved in early<br />
impairment of insulin-induced vaso<strong>di</strong>lation on resistance vessels of spontaneously<br />
hypertensive rats (SHR)<br />
Gagliar<strong>di</strong> Sara, Potenza M.A., Marasciulo F.L., Montagnani M.<br />
Department of Pharmacology and Human Physiology - Me<strong>di</strong>cal School - University of Bari,<br />
70124 Bari, Italy<br />
58. Vaso<strong>di</strong>lator activity of hydrogen sulfide (H 2 S) in human isolated mesenteric arteries<br />
Materazzi Serena 1 , Patacchini R. 2 , Nassini R. 1 , Zagli G. 1 , Giannelli M. 1 , Bechi P. 1 , Nicoletti P. 1 ,<br />
Geppetti P. 1, Harrison S. 1<br />
1 Department of Critical Care Me<strong>di</strong>cine & Surgery, University of Florence, Florence, Italy; and<br />
2 Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy; Florence, Italy<br />
59. The vasorelaxant and anti-inflammatory action of raloxifene in rat aorta is partially<br />
me<strong>di</strong>ated by estrogen receptor alpha<br />
Pelosi Valeria 1,2 , Sancito P. 1,2 , Bolego C. 1 , Pinna C. 1 , Corsini A. 1 , Gaion R.M. 2 , Cignarella A. 1,2<br />
1 Department of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan;<br />
2 Department of Pharmacology and Anaesthesiology, University of Padova, Largo Meneghetti<br />
2, 35131 Padova, Italy<br />
83<br />
60. Inhibitors of cystathionine --lyase (CSE), propargylglycine and -cyanoalanine,<br />
modulate arterial vasorelaxation in rat aorta<br />
Vellecco Valentina, Di Lorenzo A., De Gruttola L., Brancaleone V., Roviezzo F., Bucci M., Cirino<br />
G.<br />
Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples<br />
“Federico II”<br />
61. Direct effects of ticlopi<strong>di</strong>ne and clopidogrel on resistance vessel in vitro<br />
Frol<strong>di</strong> Guglielmina, Montopoli M., Dorigo P., Caparrotta L.<br />
Department of Pharmacology and Anesthesiology -Pharmacology Division- Largo E.<br />
Meneghetti 2, University of Padova (Italy)<br />
62. Asymmetric <strong>di</strong>methylarginine (ADMA) induces vascular endothelium impairment and<br />
aggravates myocar<strong>di</strong>al ischemia-reperfusion injury in rats<br />
Bonomo Sara M. a , De Gennaro Colonna V. a , Manfre<strong>di</strong> B. a , Ferrario P. a ,.Bianchi M. a , Berti M. b ,<br />
Guazzi M. c , Berti F. a , Rossoni G. a<br />
a Department of Pharmacology, Chemoterapy and Me<strong>di</strong>cal Toxicology, University of Milano, Via<br />
Vanvitelli 32, Italy; b Institute of Car<strong>di</strong>ology, Monzino Car<strong>di</strong>ology Center, IRCCS, Milan, Italy;<br />
c Car<strong>di</strong>opulmonary Laboratory, Car<strong>di</strong>ology Division, University of Milano, San Paolo Hospital,<br />
Milano, Italy<br />
pag_dx.indd 1 30/05/2007 3.55.30
63. Anti-inflammatory and car<strong>di</strong>oprotective activities of synthetic HDL containing the<br />
37PA peptide<br />
Gomaraschi Monica*, Remaley A. # , Rossoni G. § , Franceschini G.*, Calabresi L.*<br />
*Center Enrica Grossi Paoletti, Department of Pharmacological Sciences, University of Milano,<br />
Italy, # Molecular Disease Section, National Heart, Lung, and Blood Institute, National<br />
Institutes of Health, Bethesda, MD, USA and § Department of Pharmacological Sciences,<br />
University of Milano, Italy<br />
64. Human pharmacology of naproxen so<strong>di</strong>um<br />
Capone Marta L., § † , Tacconelli S.,§ † Sciulli M.G. §† , Anzellotti P. §† , Di Francesco L. §† , Merciaro<br />
G. ‡ , Di Gregorio P. ‡ , Patrignani P. §†<br />
§ Department of Me<strong>di</strong>cine and Aging, School of Me<strong>di</strong>cine, “G.d’Annunzio” University; † “G.<br />
d’Annunzio” University Foundation, Ce.S.I.; and ‡ SS Annunziata Hospital, Chieti, Italy<br />
65. Doxorubicin car<strong>di</strong>otoxicity and apoptosis: variation of exposure times to the same<br />
cumulative dose<br />
Vitelli Maria Redenta, Piegari E., Rodolico G., Leone L., Marino L., Oliva P., Rossi F., Berrino L.<br />
Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />
Surgery, Second University of Naples – Via Costantinopoli, 16 – 80138 Napoli<br />
84<br />
66. Apoptotic cell death in doxorubicin-induced car<strong>di</strong>omyopathy: role of peroxynitrite<br />
and LOX-1 receptor modulation<br />
Sculco Francesca 1 , Muscoli Ca. 1,2 , Palma E. 1 , Sacco I. 1 , Visalli V. 1 , Costa N. 1 , Rotiroti D. 1 ,<br />
Romeo F. 3 , Mollace V 1,2<br />
1 Faculty of Pharmacy, University “Magna Graecia” of Catanzaro, Italy; 2 San Raffaele Pisana<br />
IRCCS, Rome, Italy; 3 Chair of Car<strong>di</strong>ology, University of Rome “Tor Vergata”, Rome, Italy;<br />
4 Faculty of Pharmacy, University of Messina, Italy<br />
67. Ubiquitin-proteasome system contributes to the inflammatory injury of Experimental<br />
Acute <strong>di</strong>abetic myocar<strong>di</strong>al infarct<br />
D’Amico Michele 1,2 , Di Filippo C. 1,2 , Martella R. 3 , Rossi F. 1,2 ,<br />
1 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology L. Donatelli, 2 ”Excellence<br />
Centre for Car<strong>di</strong>ovascular Disease”, and 3 Department of Geriatrics and Metabolic Diseases,<br />
2nd University of Naples, Italy<br />
68. Effects of oral essential amino acid supplementation in cachectic insuline resistance<br />
patients with chronic heart failure<br />
Boschi Federica * , Verri M. * , Dossena M. * , Opasich C.°, Aquilani R.^, Gualco A. ° , Pastoris O * .<br />
* Department of Physiological & Pharmacological Sciences, University of Pavia, Pavia, Italy;<br />
^IRCCS “S. Maugeri” Foundation, Montescano, Italy; °IRCCS “S. Maugeri” Foundation, Pavia<br />
69. Gender-<strong>di</strong>fferences in no and edhf modulation of vascular reactivity in rabbit<br />
mesenteric artery<br />
Fabi Fulvia, Coletta T., Lorenzini P., Del Basso Orsini P.<br />
Department of Drug Research and Evaluation, Istituto Superiore <strong>di</strong> Sanità, Roma, Italy<br />
70. Gender <strong>di</strong>fferences in nitric oxide production by inducible nitric oxide synthase in<br />
cytokine-stimulated rabbit carotid arteries<br />
Del Basso Orsini Paola, Calciano S., Fabi F.<br />
Department of Drug Research and Evaluation, Istituto Superiore <strong>di</strong> Sanità, Roma, Italy<br />
pag_sx.indd 1 30/05/2007 3.56.26
Farmacologia del sistema nervoso<br />
Poster 71 – 98<br />
71. Time-dependent and sequential modulation of signaling cascades, CREB activation<br />
and BDNF expression induced by antidepressants<br />
Tar<strong>di</strong>to Daniela 1 , Tiraboschi E. 1 , Barbiero V. S 1 , Moraschi S. 2 , Cattaneo A. 2 , Gennarelli M. 2 ,<br />
Racagni G. 1 , Popoli M. 1<br />
1 Center of Neuropharmacology, Dept of Pharmacological Sciences and Center of Excelence on<br />
Neurodegenerative Diseases, University of Milan, Italy. 2 Genetics Unit, I.R.C.C.S. “S. Giovanni<br />
<strong>di</strong> Dio”, Fatebenefratelli, Brescia, and Division of Biology and Genetics, Department of<br />
Biome<strong>di</strong>cal Sciences and Biotechnologies, University of Brescia, Brescia, Italy<br />
72. Chronic antidepressant treatments induces specific changes in BDNF expression and<br />
subcellular localization<br />
Maj Paola F. 1 , Calabrese F. 1 , Molteni R. 1 , Cattaneo A. 3 , Gennarelli M. 2,3 , Racagni G. 1 , Riva M.<br />
A. 1<br />
1 Center of Neuropharmacology, Pharmacol. Sciences Dept., University of Milan, Via Balzaretti<br />
9, 20133 Milan, Italy. 2 I.R.C.C.S. San Giovanni <strong>di</strong> Dio-Fatebenefratelli, Brescia, Italy. 3 Biol.<br />
and Gen. Div., Dept. Biome<strong>di</strong>cals and Biotechnology Sciences, University of Brescia<br />
73. Human astrocytes can be induced by imipramine to <strong>di</strong>fferentiate into cells with<br />
neuronal phenotype<br />
1 Cabras Stefano, 1 Reali C., 1 Scorciapino L., 1 Saba F., 1 Sirigu R., 2 Biggio G., 1 Sogos V.<br />
1 Department of Cytomorphology, University of Cagliari<br />
2 Department of Experimental Biology “Bernardo Loddo”, University of Cagliari<br />
74. Vagus nerve stimulation like antidepressant drugs enhances norepinephrine release<br />
and BDNF gene expression in the rat brain<br />
Gorini Giorgio 1,4 , Biggio F. 1 , Caria S. 1 , Follesa P. 1,2 , Marrosu F. 3 , Dazzi L. 1,2 , and Biggio G. 1,2<br />
University of Cagliari, Dept. of Experimental Biology, Section of Neuroscience 1 , Cntr. of<br />
Excellence for the Neurobiology of Dependence 2 , Dept. of Neurological and Car<strong>di</strong>ovascular<br />
Sciences 3 , 09123 Cagliari, Italy; University of Sassari, Dept. of Pharmacology, Gynecology<br />
and Obstetrics, Section of Pharmacology 4 , 07100 Sassari, Italy<br />
85<br />
75. Escitalopram alters BDNF, CREB and CaRF gene expression in <strong>di</strong>screte rat brain<br />
areas<br />
Benatti Cristina 1 , Alboni S. 1 , Capone G. 1 , Corsini D. 1 , Caggia F. 1 , Tascedda F. 1 , Blom Joan<br />
M.C. 2 , Brunello N. 1<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Modena, Italy;<br />
2 Department of Pe<strong>di</strong>atrics, University of Modena and Reggio Emilia, Modena, Italy<br />
76. Acetyl salicylic acid increases the response of escitalopram in a rat model of<br />
depression<br />
Alboni Silvia 1 , Benatti C. 1 , Capone G. 1 , Caggia F. 1 , Corsini D. 1 , Tascedda F. 1 , Mendlewicz J. 2 ,<br />
Brunello N. 1<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Modena and Reggio Emilia, Modena, Italy;<br />
2 Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium<br />
77. Synaptoproteomics of an animal model of depression combining genetic<br />
vulnerability and early-life stress<br />
Mallei Alessandra a , Tiraboschi E. a , Giambelli R. a , El Khoury A. b , Mathè A.A. b , Racagni G. a ,<br />
Popoli M. a<br />
a Center of Neuropharmacology-Department of Pharmacological Sciences, University of Milano<br />
(Italy). b NEUROTEC Department, Division of Psychiatry, Karolinska Institutet, Stockholm,<br />
(Sweden)<br />
pag_dx.indd 1 30/05/2007 3.57.25
78. Group-II metabotropic glutamate receptor ligands as adjunctive drugs in the<br />
treatment of depression: a new strategy to shorten the latency of antidepressant<br />
me<strong>di</strong>cation?<br />
Matrisciano Francesco a,b , Panaccione I. a , Zusso M. d , Giusti P. d , Tatarelli R. b , Caruso A. a ,<br />
Iacovelli L. a , Scaccianoce S. a , Mathé A.A. c , Gruber S.H. c , Melchiorri D. a , Girar<strong>di</strong> P. b ,<br />
F. Nicoletti a,e<br />
a Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />
Piazzale Aldo Moro, 5, 00185 Rome, Italy. b Department of Psychiatry and Psychological<br />
Me<strong>di</strong>cine, Sant’Andrea Hospital, University of Rome “La Sapienza”; c Karolinska Institute,<br />
Department of Clinical Neuroscience - Psychiatry, Karolinska University Hospital Hud<strong>di</strong>nge,<br />
Stockholm, Sweden; d Department of Pharmacology and Anesthesiology, University of Padova,<br />
Italy; e I.N.M. Neuromed, Pozzilli, Italy<br />
79. Modulation of pre-synaptic and post-synaptic proteins after prolonged treatment<br />
with antipsychotic drugs<br />
Frasca Angelisa 1 , Fumagalli F. 1 , Racagni G. 1 , Riva M.A. 1<br />
1 Center of Neuropharmacology, Department of Pharmacological Sciences University of Milan,<br />
Via Balzaretti 9, 20133 Milan (Italy)<br />
86<br />
80. Effect of typical and atypical antipsychotics on in vivo dopamine transmission in<br />
<strong>di</strong>fferent brain areas<br />
Ullu Laura M., Valentini V., Tanda G., De Luca M.A., Di Chiara G.<br />
Department of Toxicology, Centre of Excellence “Neurobiology of Ad<strong>di</strong>ction", University of<br />
Cagliari, Italy<br />
81. Agonist activity of N-Desmethylclozapine, a major clozapine metabolite, at delta<br />
opioid receptors<br />
Olianas Maria C., Dedoni S., Garau L., Onali P.L.<br />
Section of Biochemical Pharmacology, Department of Neuroscience, University of Cagliari,<br />
Cagliari, Italy<br />
82. Haloperidol both prevents and reverses quinpirole-induced non regulatory water<br />
intake, a putative animal model of psychogenic poly<strong>di</strong>psia<br />
Amato Davide 1 , Stasi Maria Antonietta 2 , Borsini Franco 2 , Nencini Paolo 1<br />
1 Department of Human Phisiology and Pharmachology, University of Rome Sapienza,<br />
2 Research and Development Division, sigma-tau Industrie Farmaceutiche Riunite SpA,<br />
Pomezia<br />
83. Different role of NMDA receptors in the rostral and caudal part of thalamic reticular<br />
nucleus in a rat model of absence epilepsy, the WAG/Rij rat<br />
Citraro Rita 1 , Marra R 2 ., Scicchitano F 1 ., Russo E 1 ., Ferreri Ibbadu G 1 ., De Sarro<br />
G 1 .<br />
1 Section of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine and Surgery, University of Catanzaro, Italy, 2 ISBAF CNR, Department of<br />
Pharmacology, Faculty of Pharmacy, University of Catanzaro, Catanzaro, Italy<br />
84. Effects of adenosine receptor agonists and antagonists administration on spikewave<br />
<strong>di</strong>scharge in a genetic model of generalized absence epilepsy<br />
Citraro Rita 1 , Ferreri G. 1 , Russo E. 1 , D’Auro M. 2 , Ciccarelli R. 2 , De Sarro G. 1<br />
1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine and Surgery, University of Catanzaro, 2 Chair of Pharmacology, Faculty of Me<strong>di</strong>cine<br />
and Surgery, University of Chieti, Italy<br />
pag_sx.indd 1 30/05/2007 3.58.24
85. Effects of the focal administration of MGLU2/3 receptor ligands in selected brain<br />
areas of WAG/RIJ rat, a genetic animal model of absence of epilepsy<br />
1 De Sarro Giovambattista, 1 Citraro R., 2 Ngomba R., 1 Russo E., 2 Battaglia G.,<br />
2,3 Nicoletti F.<br />
1 Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery,<br />
University of Catanzaro, Catanzaro, Italy,<br />
2 I.N.M. Neuromed, 86077 Pozzilli, Italy,<br />
3 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy<br />
86. Homocysteine induced an increase of absence seizures in the electrocographic<br />
pattern of WAG/Rij rat<br />
Ferreri Ibbadu Guido 1 , Citraro R. 1 , Marra R. 2 , Siniscalchi A. 1,3 , Russo E. 1 , De<br />
Sarro G. 1<br />
1 Section of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine and Surgery, University of Catanzaro, Italy, 2 ISBAF CNR, Department of<br />
Pharmacology, Faculty of Pharmacy, University of Catanzaro, Catanzaro, 3 Depatment of<br />
Neuroscience, Annunziata Hospital, Cosenza, Italy<br />
87. Effects of non-competitive AMPA receptor antagonists injected into some brain areas<br />
of WAG/Rij rats, an animal model of generalized absence epilepsy<br />
1 Ferreri I. Guido, 2 Palma E., 2 Marra R., 1 Citraro R., 1 Russo E., 1 Curinga C., 3 Gitto R., 3 Chimirri<br />
A, 1 De Sarro G.<br />
1 Section of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine and Surgery, University of Catanzaro. 2 National council of research institute of<br />
neurological science, Catanzaro. 3 Department of Me<strong>di</strong>cinal Chemistry, Faculty of Pharmacy,<br />
University of Messina, Italy<br />
88. Selective activation of metabotropic glutamate receptors subtype 4 enhances<br />
spontaneous and evoked absence seizures<br />
Santolini Ines 1,4 , Ngomba R. 1 , Biagioni F. 1 , Citraro R. 2 , Radura A. 3 , Battaglia G. 1 , Bruno V. 1,4 ,<br />
Ferraguti F. 5 , Van Luijtelaar G. 3 , De Sarro G. 2 , Nicoletti F. 1,4<br />
1 I.N.M. Neuromed, Pozzilli, Italy; 2 Dept. of Exp. & Clin. Med., Univ. of Catanzaro, Italy; 3 Dept.<br />
of Biol. Psychol., Univ. of Nijmegen, The Netherlands; 4 Dept. of Hum. Physiol. & Pharm., Univ.<br />
“La Sapienza”, Rome, Italy; 5 Dept. of Pharm., Univ. of Innsbruck, Austria<br />
87<br />
89. Prenatal ethanol exposure effects on MAP-kinases pathway in a genetic model of<br />
absence epilepsy: the WAG/RIJ rat<br />
1 Arbitrio Mariamena, 3 Costa N., 1 Vecchio I., 1 Marra R., 1 Iannone M., 1 Strongoli M.C., 2 Cuda G.,<br />
2 Casadonte R., 2 De Sarro G., 1,3 Rotiroti D<br />
1 National Council of Research Institute of Neurological Science-Catanzaro. 2 Department of<br />
Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery-Catanzaro. 3 Chair of<br />
Pharmacology, Faculty of Pharmacy-Catanzaro<br />
90. Topiramate dose-dependently mo<strong>di</strong>fies slow inhibitory post synaptic potentials<br />
evoked in rat olfactory cortical neurones in in vitro<br />
1 Russo Emilio, 1 De Sarro G., 2 Constanti A.<br />
1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine and Surgery, University of Catanzaro, Catanzaro, Italy; 2 Pharmacology Department,<br />
School of Pharmacy, University of London, London, UK<br />
91. Zonisamide induces a slow dose-dependent hyperpolarization in rat olfactory<br />
cortical neurones in vitro<br />
1 Russo Emilio, 1 Scarfone S., 1 De Sarro G.<br />
1 Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery,<br />
University of Catanzaro, Catanzaro, Italy<br />
pag_dx.indd 1 30/05/2007 4.02.38
92. Effects of nitric oxide influence on experimentally-induced hyperexcitability of the<br />
hippocampus: in vivo and in vitro comparative electrophysiological study in the rat<br />
Rizzo Valerio 1 , Ferraro G. 1 , Sardo P. 1 , Carletti F. 1 , D’Agostino S. 1 , La Grutta V. 1 , Cannizzaro<br />
G. 2<br />
1 Dip. Me<strong>di</strong>cina Sperimentale, Sez. Fisiologia umana, Università <strong>di</strong> Palermo, Italy. 2 Dip. Scienze<br />
Farmacologiche, Università <strong>di</strong> Palermo, Italy<br />
93. Changes in neuroactive steroids levels, GABA A receptor plasticity and sensitivity to<br />
anxiolytic drugs induced by neonatal exposure to estrogen<br />
Calza Arianna, Sogliano C., Marra C.,Paganelli P.,Santoru F., Angioni M.M.,Biggio G.,Concas A.<br />
Department of Experimental Biology and Centre of Excellence for the “Neurobiology of Drug<br />
Dependence”, University of Cagliari, Italy<br />
94. Subchronic administration of statins reduces plasma and brain content of<br />
neuroactive steroids<br />
1 Dore Riccardo, 4 Pisu M.G., 2 Muntoni S., 134 Serra M., 134 Biggio G.<br />
1 Department of Experimental Biology; 2 Department of Toxicology, Unit of Oncology and<br />
Molecular Pathology; 3 Center of Excellence for the Neurobiology of Dependence; 4 CNR<br />
Institute of Neuroscience, Section of Cagliari, University of Cagliari<br />
88<br />
95. Flumazenil-sensitive dose-related physical dependence in planarians produced by<br />
two benzo<strong>di</strong>azepine and one non-benzo<strong>di</strong>azepine benzo<strong>di</strong>azepine receptor agonists<br />
Cavallo Federica b , Raffa R. B. a , Capasso A. b<br />
a Department of Pharmaceutical Sciences, Temple University School of Pharmacy, Philadelphia,<br />
PA, USA, b Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy<br />
96. GABAergic drugs become neurotoxic in cortical neurons pre-esposed to<br />
brain_derived neurotrophic factor<br />
Molinaro Gemma 1 , Battaglia G. 1 , Riozzi B. 1 , Storto M. 1 , Fucile S. 1,2 , Eusebi F. 1,2 , Nicoletti F. 1,2<br />
Bruno V. 1,2<br />
1 Istituto Neurologico Me<strong>di</strong>terraneo Neuromed, Pozzilli, Italy; 2 Department of Human<br />
Physiology and Pharmacology, University of Rome “La Sapienza”, Rome, Italy<br />
97. Expression patterns of promoters for NPY Y1 and Y5 receptors in Y5RITTA and<br />
Y1RVENUS bac transgenic mice<br />
Longo Angela, Oberto A., Acquadro E., Busb T., Sprengel R., Eva C.<br />
Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>cina Legale; Sezione <strong>di</strong> Farmacologia,<br />
Università <strong>degli</strong> stu<strong>di</strong> <strong>di</strong> <strong>Torino</strong>. Department of Molecular Neurobiology Max Planck Institute<br />
for Me<strong>di</strong>cal Research, 69120, Heidelberg, Germany<br />
98. Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by<br />
fluctuations in the brain content of neuroactive steroids during ethanol withdrawal<br />
in mice<br />
Bertocchi Ilaria, Eva C., Mele P., Collura D., Pisu M.P., Serra M., Biggio G.<br />
Dip.Anatomia, Farmacologia e Med Leg, Sez. Farmacologia, Università <strong>di</strong> <strong>Torino</strong>, Italy; Dip<br />
Biol Sperimentale, Sez Neuroscienze, Università <strong>di</strong> Cagliari, Italy; Centro Ecc. Neurobiol.<br />
Dipendenza, Università <strong>di</strong> Cagliari, Italy; C.N.R. Ist. Neurosci, Neuropsicofarmac., Cagliari<br />
Farmacologia dei processi degenerativi<br />
Poster 99 – 124<br />
99. Sulforaphane inhibits 6-hydroxydopamine-induced apoptosis by upregulation of<br />
MEK/ERK and PI3K/AKT in human neuronal cells<br />
Tarozzi Andrea 1 , Morroni F. 1 , Merlicco A. 1 , Angeloni C. 2 , Hrelia S. 2 , Cantelli-Forti G. 1 , Hrelia P. 1<br />
1 Department of Pharmacology, 2 Department of Biochemistry "G. Moruzzi", Alma Mater<br />
<strong>Stu<strong>di</strong></strong>orum - University of Bologna, via Irnerio 48, 40126 Bologna<br />
pag_sx.indd 1 30/05/2007 4.05.37
100. Characterization of the antiparkinsonian effects of the new adenosine A 2A receptor<br />
antagonist ST1535: acute and subchronic stu<strong>di</strong>es in rats<br />
Tronci Elisabetta (1) , Simola N. (1) , Borsini F. (4) , Schintu N. (1) , Frau L. (1) , Carminati P. (4) , Morelli<br />
M. (1,2,3)<br />
(1) Department of Toxicology, (2) Centre of Excellence for Neurobiology of Dependence, (3) CNR<br />
Institute of Neuroscience, University of Cagliari, Italy, (4) Sigma-Tau Industrie Farmaceutiche<br />
Riunite S.p.A., Pomezia (Rome), Italy<br />
101. Evaluation of the neuroprotective effect of THE A 2A receptor antagonist SCH58261<br />
on the MPTP mouse model of Parkinson’s <strong>di</strong>sease<br />
Schintu Nicoletta, Carta A.R., Morelli M.<br />
Department of Toxicology, University of Cagliari, Italy<br />
102. Mitochondrial factors involved in Parkinson's <strong>di</strong>sease by MPTP toxycity in Macaca<br />
Fascicularis and drug effect<br />
Brera Francesca, Gorini A., Villa R.F.<br />
Dipartimento <strong>di</strong> Scienze Fisiologiche-Farmacologiche Cellulari-Molecolari Sezione <strong>di</strong><br />
Farmacologia e Biotecnologie Farmacologiche Piazza Botta, 11 - 27100 Pavia, Università <strong>degli</strong><br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> Pavia<br />
103. CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity<br />
Sgadò Paola, Viaggi C., Vaglini F., Par<strong>di</strong>ni C., Caramelli A., Corsini G.U.<br />
Department of Neuroscience, Section of Pharmacology, University of Pisa and Center of<br />
Excellence ‘AMBISEN’ for the study of Environmental Toxins and CNS Diseases, Pisa, Italy<br />
104. Behavioural characterization of engrailed mutant mice as model of Parkinson’s<br />
<strong>di</strong>sease<br />
Pontis Silvia 1 , Pinna A. 2 , Sgadò P. 3 , Corsini G.U. 3 , Morelli M. 1,2<br />
1 Department of Toxicology, University of Cagliari, Italy. 2 CNR Institute for Neuroscience,<br />
Cagliari, Italy. 3 Department of Neuroscience, Pisa, Italy<br />
89<br />
105. Low and high dyskinetic treatments induce <strong>di</strong>fferent motor responses and mRNA<br />
changes in Caudate-Putamen in the 6-OHDA rat model of Parkinson’ s <strong>di</strong>sease<br />
Frau Lucia 1 , Carta A. R. 1 , Pinna A. 2 , Pontis S. 1 , Morelli M. 1,2 .<br />
1 Department of Toxicology, University of Cagliari. 2 CNR, Institute of Neuroscience, Cagliari<br />
106. Blockade of pallidal adenosine A 2A receptors potentiates contralateral rotational<br />
behavior induced by L-DOPA and dopaminergic agonists in hemiparkinsonian rats<br />
Simola Nicola a , Fenu S. a , Baral<strong>di</strong> P.G. b , Tabrizi M. A. b , Morelli M. a<br />
a Department of Toxicology and Centre of Excellence for Neurobiology of Dependence,<br />
University of Cagliari, Cagliari, Italy; b Department of Pharmaceutical Sciences, University of<br />
Ferrara, Ferrara, Italy<br />
107. Analysys of the MPP + uptake in mesencephalic cell cultures from CYP 2E1 Knock-out<br />
mice<br />
Caramelli Andrea, Par<strong>di</strong>ni C., Viaggi C., Vaglini F., Sgadò P., Corsini G.U.<br />
Dip. <strong>di</strong> Neuroscienze Sez. Farmacol. Università <strong>di</strong> Pisa<br />
108. Effects of <strong>di</strong>rect and in<strong>di</strong>rect cannabinoid receptor agonists on levodopa-induced<br />
dyskinesias ina rat model of Parkinson's <strong>di</strong>sease<br />
Morgese Maria Grazia 1,3 , Cassano T. 1 , Trabace L. 1 , Cuomo V. 2 , Giuffrida A. 3<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Foggia, Italy;<br />
2 Department of<br />
Pharmacology and General Physiology, University of Rome, ‘La Sapienza’, Italy; 3 Department<br />
of Pharmacology, University of Texas Health Science Center at San Antonio, Texas, U.S.A<br />
pag_dx.indd 1 30/05/2007 4.09.03
109. The nitric oxide-leleasing derivative of furbiprofen HCT1026 decreases vulnerability<br />
of nigrostriatal dopaminergic neurons to MPTP via a switch of glia proinflammatory<br />
phenotype: implications for treatment of Parkinson's <strong>di</strong>sease<br />
L’Episcopo Francesca 1 , Testa N. 1 , Caniglia S. 1 , Tirolo C. 1 , Giaquinta G. 1 , Arcieri P. 1 , Serra<br />
P.A. 2 , Bazzu G. 2 , Morale M. C. 1 , Impagnatiello F. 3 , Marchetti B. 1,2<br />
1 Neuropharmacology, OASI Institute Researc and Care (IRCCS) Troina (EN), Italy and<br />
2 Department of Pharmacology, University of Sassari, Me<strong>di</strong>cal School, Sassari, Italy, and<br />
3 Nicox Research Institute, Bresso, Milano, Italy<br />
110. Neuroinflammatory response in the acute MPTP rodent model of Parkinson's<br />
<strong>di</strong>sease: time-dependent correlation with histopathological, neurochemical and<br />
behavioral response to nigrostriatal injury and repair<br />
L’Episcopo Francesca 1 , Salani G. 2 , Serra P.A. 3 , Caniglia S. 1 , Tirolo C. 1 ,Giaquinta G. 1 , Testa<br />
N. 1 , Rocchitta G. 3 , Calia G. 3 , Manca A. 3 , Morale M.C. 1 , Pluchino S. 2 , Martino G. 3 , Marchetti<br />
B. 1,2<br />
1 Neuropharmacology, OASI Institute for Research and Care (IRCCS) Troina (EN), Italy<br />
2 Neuroimmunology Unit, Department of Neurology and Physiology, San Raffaele Scientific<br />
Institute, Milano, and 3 Dept. Pharmacology, University of Sassari Me<strong>di</strong>cal School, Sassari,<br />
Italy<br />
90<br />
111. S100B protein promoted tau protein hyperphosphorilation through DKK-1 protein<br />
up-regulation and relative WNT pathway <strong>di</strong>sruption in cultured human neurons<br />
Esposito Giuseppe 1 , Scuderi C. 1, 4 , De Filippis D. 2 , Iuvone T. 2 , Savani C. 1, 5 , Lu Jie 3 , Sheen<br />
Volney 3 , Steardo L. 1<br />
1 Department of Human Physiology and Pharmacology “Vittorio Erspamer”, University of Rome<br />
“La Sapienza” - 2 Department of Experimental Pharmacology, University of Naples Federico<br />
II.<br />
3 Department of Neurology, Beth Israel Deaconess Me<strong>di</strong>cal Center, Harvard Me<strong>di</strong>cal School,<br />
Boston<br />
4 Department of Pharmacological Sciences, University of Palermo. 5 Department of Human<br />
Physiology and Pharmacology, University of Bari<br />
112. Amyloid Precursor Protein and Presenilin1 Interact with the Adaptor Grb2 and<br />
Modulate ERK1,2 Signaling<br />
Clau<strong>di</strong>o Russo 5 , Nizzari M., Venezia V. 1 , Repetto E. 1 , Corsi V. 2 , Magrassi R. 2 , Gagliani M.C. 3 ,<br />
Florio T. 1 , Schettini G. 1 , Tacchetti C. 3 , Russo T. 4 , Diaspro A. 2<br />
1 Dip. Oncologia, Biologia e Genetica, Università <strong>di</strong> Genova, 2 Dip. Fisica, Università <strong>di</strong> Genova,<br />
3 Dip.Me<strong>di</strong>cina Sperimentale, Università <strong>di</strong> Genova, 4 Dip.Biochimica, Università <strong>di</strong> Napoli<br />
Federico II, 5 Dip. Scienze per la Salute, Università del Molise<br />
113. Nitric oxyde and dopaminergic system: neurochemical interactions in -amyloid<br />
injected rats<br />
Schiavone Stefania (a) , Lanni C. (b) , Cuomo V. (c) , Trabace L. (a) , Govoni S. (b)<br />
(a) Dept. Biome<strong>di</strong>cal Sciences, University of Foggia, Foggia, Italy; (b) Dept. of Experimental<br />
and Applied Pharmacology, University of Pavia, Pavia, Italy; (c) Dept. of Human Physiology<br />
and Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy<br />
114. Alterations of tau protein and effect of lithium salts treatment on TgCRND8 mice<br />
Rosi Maria Cristina, Grossi C., Fiorentini A., Luccarini I., Casamenti F.<br />
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy<br />
pag_sx.indd 1 30/05/2007 4.18.41
115. Long-term treatment with CHF5074, a novel gamma-secretase modulator, markedly<br />
reduces brain beta-amyloid in a transgenic mouse model of Alzheimer's <strong>di</strong>sease<br />
Imbimbo Bruno P. 1 , Del Giu<strong>di</strong>ce E. 2 , Miccichè F. 2 , Colavito D. 2 , D'Arrigo A. 2 , Dalle Carbonare<br />
M. 2 , Villetti G. 1 , Facchinetti F. 1 , Volta R. 1 , Pietrini V., 3 Baroc M. F. 3 , Leon A. 2<br />
1 Research & Development, Chiesi Farmaceutici, Via Palermo 26/A, 43100 Parma; 2 Research &<br />
Innovation, Via Svizzera 16, 35127 Padua; 3 Department of Neurosciences, Neurology Section,<br />
University of Parma, 43100 Parma<br />
116. Angiogenesis in neurodegenerative processes: loss of regulatory A function<br />
contributes to endothelial degeneration<br />
Donnini Sandra, Cantara S., Giachetti A., Ziche M.<br />
Pharmacology Section, Dept. Molecular Biology, University of Siena, Italy<br />
117. The BH4 domain of Bcl-xl counteracts beta amyloid peptide toxicity on capillary<br />
endothelium<br />
Solito Raffaella, Donnini S., Cantara S., Giochetti A., Ziche M.<br />
Section of Pharmacology, Department of Molecular Biology, University of Siena<br />
118. Mitochondrial dysfunctions in a transgenic murine model of Alzheimer's <strong>di</strong>sease<br />
1 Cassano Tommaso, 2 Servid<strong>di</strong>o G., 2 Bellanti F., 2 Tamborra R., 1 Macheda T., 1 Morgese M.G.,<br />
1 Trabace L., 3 Oddo S., 3 LaFerla F.M., 4 Cuomo V., 2 Vendemiale G.<br />
1 Dept. of Biochemical Sciences Univ. of Foggia, Italy; 2 Dept. of Me<strong>di</strong>cal and Occupational<br />
Sciences, Univ. of Foggia, Italy; 3 Dept. of Neurobiology and Behavior, Univ. of California,<br />
Irvine, U.S.; 4 Dept. of Human Physiology and Pharmacology, Univ. of Rome “La Sapienza”,<br />
Italy<br />
119. Glia me<strong>di</strong>ates neuroprotection by estrogen against ß-amyloid toxicity: effect<br />
amplified by estrogen receptor overexpression<br />
Carbonaro Viviana 1 , Frasca G. 1 , Merlo S. 1 , Caraci F. 2 , Copani A. 2 , Sortino M.A. 2<br />
Departments of 1 Experimental and Clinical Pharmacology and 2 Pharmaceutical Sciences,<br />
University of Catania<br />
91<br />
120. Cannabi<strong>di</strong>ol in vivo suppresses A induced reactive gliosis<br />
Scuderi Caterina 1,2 , Esposito G. 1 , Savani C. 1,4 , De Filippis D. 2 , Iuvone T. 2 , Steardo L. 1<br />
1 Department of Human Physiology and Pharmacology “Vittorio Erspamer”, University of Rome<br />
“La Sapienza” -<br />
2 Department of Pharmacological Sciences, University of Palermo.<br />
3 Department of Experimental Pharmacology, University of Naples Federico II. 4 Department of<br />
Human Physiology and Pharmacology, University of Bari<br />
121. In vivo characterization of DKK-1 expression in transgenic animal models of<br />
Alzheimer's <strong>di</strong>sease<br />
Fiorentini Anna, Rosi M. C., Luccarini I., Grossi C., Casamenti F.<br />
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy<br />
122. in vivo effect of Clioquinol treatment in a mouse model of Alzheimer’s <strong>di</strong>sease<br />
Grossi Cristina, Rosi M. C., Fiorentini A., Luccarini I. , Casamenti F.<br />
Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy<br />
123. Long-term treatment with a new anti-oligomeric beta-amyloid vaccine markedly<br />
reduces brain beta-amyloid load in a transgenic mouse model of Alzheimer's <strong>di</strong>sease<br />
Imbimbo Bruno P. 1 , Pietrini V., 2 Baroc M.F. 2 , Del Giu<strong>di</strong>ce E. 3 , Miccichè F. 3 , Colavito D. 3 ,<br />
D'Arrigo A. 3 , Dalle Carbonare M. 3 , Leon A. 3 , Villetti G. 1 , Facchinetti F. 1 , Moretto N. 4 , Ottonello<br />
S. 4<br />
1 Chiesi Farmaceutici, Via Palermo 26/A, Parma; 2 Department of Neurosciences, University of<br />
Parma, Parma; 3 Research & Innovation, Via Svizzera 16, Padua; 4 Department of Biochemistry<br />
and Molecular Biology, University of Parma, Viale G.P. Usberti 23/A, Parma<br />
pag_dx.indd 1 30/05/2007 4.20.22
124. Discovery of a series of molecules acting as potent alpha7 nAChR agonists with procognitive<br />
and neuroprotective properties<br />
Scali Carla 1 , Gianfriddo M. 1 , Bothmann H. 1 , Diodato E. 1 , Zanelli U. 1 , Caricasole A. 1 ,<br />
Gaviraghi G. 1 , Dunlop J. 2 , Roncarati R. 1 , Terstappen G.C. 1<br />
1 Siena Biotech SpA, Siena, ITALY, 2 Wyeth Research, Princeton, NJ, USA<br />
Farmacologia del dolore<br />
Poster 125 – 135<br />
125. Periaqueductal grey metabotropic glutamate receptor subtype 7 and 8 show<br />
opposite actions on amino acid release, nociceptive behaviour and rostral<br />
ventrome<strong>di</strong>al medulla ON and OFF cell activity<br />
Marabese Ida, Rossi F., Palazzo E., Vita D., Scafuro M.A., De Novellis V., Maione S.<br />
Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, The Second<br />
University of Naples, via Costantinopoli 16, 80138 Naples<br />
126. Role of the type 2 and 3 inositol 1,4,5-trisphosphate receptor in muscarinic<br />
antinociception in mice<br />
Vivoli Elisa, Galeotti N., Norcini M., Ghelar<strong>di</strong>ni C., Bartolini A.<br />
Department of Pharmacology – Viale G. Pieraccini, 6, 50139 – Florence<br />
92<br />
127. Involvment of type 1 and 3 ryano<strong>di</strong>ne receptor in mouse muscarinic antinociception<br />
Norcini Monica, Galeotti N., Vivoli E., Ghelar<strong>di</strong>ni, C., Bartolini A.<br />
Department of Pharmacology – Viale G. Pieraccini, 6, 50139 – Florence<br />
128. Detection and quantification of endogenous N/OFQ in the rat cerebrospinal fluid,<br />
under basal and stimulated con<strong>di</strong>tions<br />
Lopetuso Giuseppe, Romual<strong>di</strong> P., Candeletti S.<br />
Dip. Farmacologia - Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Bologna<br />
129. Impaired nociception in mice lacking the prokineticin receptor 2 (PKR2)<br />
Lattanzi Roberta, Giannini E., Melchiorri P., Negri L.<br />
Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy<br />
130. The central antinociceptive effect of N-arachidonoyl-phenolamine (AM404):<br />
implication of opioidergic and serotonergic systems<br />
Ruggieri Valentina a , Vitale G. a , Pini L. A. b , Sandrini M. a<br />
a Sect. of Pharmacology, Dept. of Biome<strong>di</strong>cal Sciences, University of Modena and Reggio E. b<br />
Clinical Pharmacology Unit, University of Modena and Reggio E<br />
131. 2-chloro-2’-C-methyl-N 6 -cyclopentyladenosine, a highly selective adenosine A1<br />
receptor agonist, has antinociceptive activity in the rat<br />
Gatta Luisa, Palazzo E., De Novellis V., Rossi F., Vita D., Maione S.<br />
Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, The Second<br />
University of Naples, via Costantinopoli 16, 80138 Naples<br />
132. 2-chloro-2’-C-methyl-N 6 -cyclopentyladenosine, a highly selective adenosine A1<br />
receptor agonist, modulates the ongoing and tail flick -related activity of RVM on<br />
and off cells<br />
Guida Francesca, Rossi F., Vita D., Marabese I., De Novellis V., Maione S.<br />
Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, The Second<br />
University of Naples, via Costantinopoli 16, 80138 Naples<br />
pag_sx.indd 1 30/05/2007 4.21.22
133. NGF-induced neurite outgrowth inhibition and pain control<br />
Restivo Alessandra, Salvati P., Caccia C.,<br />
Discovery, Newron Pharmaceuticals SpA, Bresso (MI), Italy<br />
134. Analgesic effects of new piridazione derivatives<br />
Pieretti Stefano 1 , Colucci M. 1 , Di Giannuario A. 1 , Maione F. 1,2 , Giovannoni M.P. 3 , Biancalani C. 3<br />
Dal Piaz V. 3<br />
1 Department of Drug Research and Evaluation, Italian National Institute of Health, Rome;<br />
2 Department of Experimental Pharmacology, University of Naples, “Federico II”; 3 Department<br />
of Pharmaceutical Sciences, University of Florence<br />
135. The protective effect of Olive oil phenols hydroxytyrosol and oleuropein on<br />
morphine tolerance<br />
Muscoli Carolina 1,2 , Procopio A. 1 , Vetrice D. 1 , Oliverio M. 1 , Arbitrio M. 3 , Rizzo M. 1 , Costa N. 1 ,<br />
Arcone R. 1 , Giovanni S. 4 , Rotiroti D. 1 , Nistico’ G. 5 , Salvemini D. 6 , Mollace V. 1<br />
1 Dept. of Pharmacobiol. Sciences, University of Catanzaro Magna Graecia, Italy; 2 San Raffaele<br />
Pisana IRCCS, Rome, Italy; 3 ISN-CNR; 4 Dept. of Chemistry, University of Calabria, Italy;<br />
5 Dept. of Biology, Univerity of “Tor Vergata”, Italy; 6 Dept. of Int. Med, Division of Pulmonary,<br />
Critical Care and Sleep Me<strong>di</strong>cine, Saint Louis University, St Louis, USA<br />
Farmacologia e tossicologia del comportamento<br />
Poster 136 – 150<br />
136. Neuropeptide S stimulates locomotor activity and wakefulness and evokes<br />
anxiolytic-like effects in mice<br />
1 Vergura Raffaella, 1 Rizzi A., 1 Marzola G., 2 Guerrini R., 2 Salvadori S., 1 Regoli D. 1 Calo’ G.<br />
1 Dept. of Pharmacology and 2 Dept of Pharmaceutical Science, University of Ferrara, Italy<br />
93<br />
137. Repeated restraint stress and anxiolytic drugs <strong>di</strong>fferentially modulate latent<br />
inhibition in C57BL6 mice<br />
Marcello Stefania a , Mongeau R. b , Andersen J. S. c , Pani L. d,a<br />
a Neuroscienze Pharmaness S.c.a.r.l., Cagliari.<br />
b NeuroPsychoPharmacologie, Faculté de<br />
Médecine Pitié-Salpêtrière, Paris, France. c Tofla Teld, Copenhagen, Denmark. d Istitute of<br />
Biome<strong>di</strong>cal Technologies, C.N.R., Milano<br />
138. Central administration of neuropeptide S (NPS) inhibits palatable food intake in the<br />
rat<br />
Fedeli Amalia, Economidou D., Braconi S., Cippitelli A., Massi M., Ciccocioppo R.<br />
Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy<br />
139. Quinpirole-induced compulsive drinking in rats is influenced by manipulation of<br />
behavioral cost<br />
Milella Michele S., Amato D., Ba<strong>di</strong>ani A., Nencini P.<br />
Department of Human Phisiology and Pharmachology, University of Rome Sapienza<br />
140. Disturbances of eating behavior during workplace suffering<br />
Milano Walter, Petrella C., Capasso A.*.<br />
Mental Health Operations Unit District 44 ASL Napoli 1 and *Department of Pharmaceutical<br />
Sciences, University of Salerno, Italy<br />
pag_dx.indd 1 30/05/2007 4.22.34
141. Effects of systemic MPTP administration on behavior and dopamine changes in<br />
<strong>di</strong>alysate from the striatum of freely moving mice<br />
Manca Antonio a , Bazzu G. a , Calia G. a , Puggioni G. a , Rocchitta G. a , Dedola S. a , Migheli R. a ,<br />
Serra P.A. a<br />
a Department of Pharmacology, Me<strong>di</strong>cal School, University of Sassari, Viale S. Pietro 43/b,<br />
07100, Sassari, Italy<br />
142. Role of dopamine D2-like receptors in the microstructure of licking for water and<br />
so<strong>di</strong>um chloride solutions in water deprived rats<br />
D'Aquila Paolo S., Carta D., Casula M.G., Dore B., Murgia E., Serra G.<br />
Department of Drug Sciences, University of Sassari, Sassari, Italy<br />
143. Single, intense prenatal stress can <strong>di</strong>fferently affect emotional behavioUr accor<strong>di</strong>ng<br />
to the nature of the task. Influence of metyrapone<br />
Noto Giovanna, Plescia F., Cannizzaro E., Gagliano M., Provenzano G.M., Cannizzaro C.<br />
Department of Pharmacological Sciences, University of Palermo, Italy<br />
144. Manipulations of glucocorticoid induced stress response may <strong>di</strong>fferently affect the<br />
acquisition of a reward-facilitated spatial/visual learning task<br />
Barrile Vita, Plescia F., Cannizzaro G., La Barbera M., Mantia G. , Cannizzaro C.<br />
Department of Pharmacological Sciences, University of Palermo<br />
94<br />
145. Behavioural effects induced by chronic treatment with Epigallocatechin gallate<br />
(EGCG), the major catechin of green tea, in spontaneously hypertensive rat (SHR)<br />
Lemoli Mariangela, Montagnani M. , De Salvia M. A.<br />
Dept. Pharmacology and Human Physiology, Me<strong>di</strong>cal School, University of Bari, Piazza G.<br />
Cesare, 70124 Bari, Italy<br />
146. Impact of antipsychotic treatments of behavioral alterations induced by paradoxical<br />
sleep deprivation<br />
Frau Roberto 1 , Orrù M. 1 , Mereu G. 3 , Gessa G. L.i 1 , Marrosu F. 2 Bortolato M. 2<br />
1 Dept. of Neuroscience “Bernard B. Bro<strong>di</strong>e”. University of Cagliari, Cagliari, Italy<br />
2 Dept. of Car<strong>di</strong>ovascular and Neurological Science. University of Cagliari, Cagliari, Italy<br />
3 Dept. of Experimental Biology “B. Loddo”. University of Cagliari, Cagliari, Italy<br />
147. Role of GABAB receptors in the balance of epileptic and psychotic-like phenomena in<br />
DBA/2J mice<br />
Bortolato Marco 1 , Frau R. 2 , Orrù M. 2 , Piras A. P. 2 , Gessa G. L.i 2 , Castelli M.P. 2 , Mereu G. 3 ,<br />
Marrosu F. 1<br />
1 Dept. of Car<strong>di</strong>ovascular and Neurological Science. University of Cagliari, Cagliari, Italy<br />
2 Dept. of Neuroscience “Bernard B. Bro<strong>di</strong>e”. University of Cagliari, Cagliari, Italy<br />
3 Dept. of Experimental Biology “B.Loddo”. University of Cagliari, Cagliari, Italy<br />
148. Training-associated emotional arousal <strong>di</strong>fferentially modulates cannabinoid effects<br />
on object recognition memory<br />
Campolongo Patrizia 1-2 , Scaccianoce S. 1 , Modafferi A. 1 , Trezza V. 1 , Roozendaal B. 3 , Schelling<br />
G. 4 , McGaugh J.L. 3 , Cuomo V. 1<br />
1 Dept. of Human Physiology and Pharmacology, Univ. of Rome “La Sapienza”, Rome, Italy;<br />
2 Dept. of Biochemical Sciences, Univ. of Foggia, Foggia, Italy; 3 Center for the Neurobiology of<br />
Learning and Memory, Univ. of California, Irvine, USA; 4 Dept. of Anaesthesiology, Ludwig-<br />
Maximilians-University, Munich, Germany<br />
pag_sx.indd 1 30/05/2007 4.23.55
149. Gender-related effects of PREGS on emotionality, learning and memory performance<br />
in adult rats<br />
Diliberto Irene, Plescia F., Cannizzaro G., Mantia G., Provenzano G. M., Cannizzaro C.<br />
Department of Pharmacological Sciences, University of Palermo<br />
150. Use of Energy drinks in association with alcoholic beverages in a cohort of students<br />
of the School of Me<strong>di</strong>cine of the University of Messina<br />
Oteri Alessandro, Salvo F., Caputi A.P., Calapai G.<br />
Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina<br />
Sostanze d'abuso<br />
Poster 151 – 173<br />
151. Gamma hydroxybutirate (GHB) modulates NPY-Y1 receptor signalling in the<br />
amygdala of transgenic mice through GABA B receptor in a neurosteroids<br />
independent manner<br />
Mele P. a , Serra M. b,c,d , Pisu M.G. b,d , Eva C. a , Biggio G b,c,d .<br />
a Dep. Of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, Section of Pharmacology, University<br />
of Turin, Italy. b Dep. of Experimental Biology, Sec. of Neuroscience, University of Cagliari,<br />
Cagliari, Italy. c Center of Excellence for the Neurobiology of Dependence, University of<br />
Cagliari, Cagliari, Italy. d C.N.R. Institute of Neuroscience, Cagliari, Italy<br />
152. Mapping brain activity following gamma-hydroxybutyric acid administration using<br />
functional magnetic resonance imaging in rats<br />
Muntoni Anna Lisa 1 , Lu Hanbing 2 , Scholl C. A. 2 , Pistis M. 3 , Stein E.A. 2<br />
1 CNR Institute of Neuroscience and 3 Department of Neuroscience, University of Cagliari, Italy<br />
2 Neuroimaging Research Branch, National Institute on Drug Abuse, NIH, Baltimore, USA<br />
95<br />
153. Endocannabinoid system and nicotine withdrawal signs in mice<br />
Mannucci Carmen a , Pieratti A. a , Russo G. a , Caputi A. P. a , Calapai G. a<br />
a Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Section of<br />
Pharmacology, School of Me<strong>di</strong>cine, University of Messina, Italy<br />
154. Smoking cessation after the introduction of the law banning smoking in public<br />
places in Italy: a one-year follow-up study<br />
Grassi Maria Caterina*, Enea D.**, Nencini P.*<br />
*Department of Human Physiology and Pharmacology “V. Erspamer”. **Centro Policlinico<br />
Senza Fumo, “Sapienza” University of Rome, Italy<br />
155. Smoking cessation and body weight<br />
Grassi Maria Caterina*, Enea D.**, Marchetti R.**, Temperilli F.***, Villarosa F.***,<br />
Nencini P.*, Cuzzolaro M.***<br />
*Department of Human Physiology “V.Erspamer”, **Centro Policlinico Senza Fumo,<br />
***Department of Clinical Me<strong>di</strong>cine, “Sapienza” University of Rome, Italy<br />
156. Preliminary results in pivotal study on biomarkers related to smoking habits<br />
Calapai Gioacchino a , Moran<strong>di</strong> S. b , Mannucci C. a , Nunziata A. b , Caputi A. a , Bassi A. b<br />
a Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina -<br />
b BAT Italia S.p.A. R&D Via Amsterdam147, Rome<br />
157. Altered expression of metabotropic glutamate receptors in the nucleus accumbens<br />
during opiate dependence and withdrawal in the rat<br />
Modafferi Antonella M.E 1 ., Diana M. 2 , Scaccianoce S. 1<br />
1 Dept. of Human Physiology and Pharmacology - University of Rome La Sapienza; 2 Dept. of<br />
Drug Sciences - University of Sassari<br />
pag_dx.indd 1 30/05/2007 4.25.15
158. Time-dependent morphological and biochemical changes during morphine<br />
withdrawal in the rat nucleus accumbens<br />
Vinci Stefania 1 , Marinelli A. 2 , Olla A. 2 , Ibba F. 1 , Diana M. 3 , Spiga S. 2 , Acquas E. 1,4<br />
1 Department of Toxicology and 4 Centre of Excellence on Neurobiology of Ad<strong>di</strong>ction, University<br />
of Cagliari; 2 Department of Animal Biology and Ecology, University of Cagliari; 3 Department of<br />
Drug Sciences , University of Sassari<br />
159. Reciprocal effects of response contingent and non-contingent intravenous heroin on<br />
in vivo nucleus accumbens shell versus core dopamine: a repeated sampling<br />
micro<strong>di</strong>alysis study<br />
Cacciapaglia Fabio 1 , Lecca D. 1,2 , Valentini V. 1,2 , Di Chiara G. 1,2,3<br />
1 Department of Toxicology, 2 Centre of Excellence for <strong>Stu<strong>di</strong></strong>es on Ad<strong>di</strong>ctions and 3 Institute of<br />
Neuroscience, Consiglio Nazionale delle Ricerche (CNR), University of Cagliari, Italy<br />
160. Role of dopamine D 1 receptor in morphine- and lithium-induced con<strong>di</strong>tioned<br />
saccharin avoidance<br />
Simola Nicola, Fenu S., Rivas E., Di Chiara G.<br />
Department of Toxicology and Centre of Excellence for Neurobiology of Dependence,<br />
University of Cagliari, Cagliari, Italy<br />
96<br />
161. Dissociation in the modulatory effects of environment on heroin-induced<br />
psychomotor sensitization vs. heroin self-administration<br />
Celentano Michele, Caprioli D., Nencini P., Ba<strong>di</strong>ani A.<br />
Department of Human Physiology and Pharmacology, University of Rome Sapienza<br />
162. Methadone and buprenorphine maintenance effects on immune system function:<br />
comparison with untreated heroin ad<strong>di</strong>ctcs<br />
Somaini Lorenzo 1 , Franchi S. 2 , Leccese V. 1 , Gerra G. 3 , Panerai A. E 2 , Sacerdote P. 2<br />
1 Ad<strong>di</strong>ction Treatment Centre, Health Local Unit ASL 12 Biella. 2 Department of Pharmacology,<br />
via Vanvitelli 32, 20129 Milano. 3 Health Local Unit AUSL Parma<br />
163. The role of liver cytochrome isoforms on buprenorphine metabolism and it’s clinical<br />
relevance<br />
Somaini Lorenzo 1 , Gola M. 2<br />
1 2<br />
Ad<strong>di</strong>ction Treatment Centre, Health Local Unit ASL 12 Biella. Laboratory of<br />
Pharmacogenetics Lugano (CH)<br />
164. Anabolic androgenic steroids influence the expression of brain nerve growth factor<br />
in the rat<br />
Carretta Maria Teresa*, D’Amico D.*, Pace S., Modafferi A. M.E., Salemi M., Togna G.I.,<br />
Scaccianoce S.<br />
Dept. of Human Physiology and Pharmacology - University of Rome La Sapienza<br />
165. Nanomolar concentrations of anabolic-androgenic steroids amplify excitotoxic<br />
neuronal death in mixed mouse cortical cultures<br />
Orlando Rosamaria 1* , Caruso A. 1* , Molinaro G. 2 , Motolese M. 1 , Matrisciano F. 1 , Togna G. 1 ,<br />
Melchiorri D. 1 , Nicoletti F. 1,2 , Bruno V. 1,2<br />
1 Istituto Neurologico Me<strong>di</strong>terraneo Neuromed, Pozzilli, Italy; 2 Department of Human<br />
Physiology and Pharmacology, University of Rome “La Sapienza”, Rome, Italy<br />
166. Effect of nandrolone and stanozolol on pro-inflammatory cytokine production by<br />
human macrophages<br />
Trefiletti Giuliana*, Togna A.R.*, Pacifici R.**, Bacosi A.**, Di Carlo S.** Togna G.I.*<br />
* Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”<br />
**Department of Therapeutic Research and Me<strong>di</strong>cines Evaluation, Istituto Superiore <strong>di</strong> Sanità,<br />
Rome<br />
pag_sx.indd 1 30/05/2007 4.27.01
167. The K-Opioid receptor agonist U-69593 prevents cocaine-induced DARPP-32<br />
phosphorylation at THR34 in the rat brain<br />
D´Addario Clau<strong>di</strong>o, Di Benedetto M., Candeletti S., Romual<strong>di</strong> P.<br />
Dept of Pharmacology - University of Bologna - via Irnerio 48, 40126 BOLOGNA<br />
168. Facilitation of con<strong>di</strong>tioned reinstatement of cocaine-seeking following central<br />
administration of neuropeptide S<br />
Kallupi Marsida, Economidou D., Cannella N., Stopponi S., Ciccocioppo R.<br />
Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy<br />
169. Environmental modulation of cocaine and amphetamine seld administration<br />
Caprioli Daniele, Celentano M., Nencini P., Ba<strong>di</strong>ani A.<br />
Department of Human Physiology and Pharmacology, University of Rome La Sapienza<br />
170. Increased toxicity of cocaine adulterated with atropine: efficacy of <strong>di</strong>azepam<br />
Zani Alessia, Braida D., Rossoni G., Gori E. a , Capurro V., Sala M.<br />
Department of Pharmacology, Chemotherapy and Me<strong>di</strong>cal Toxicology, and a Behavioural<br />
Pharmacology and Drug Dependence Center, University of Milan, Via Vanvitelli 32, 20129,<br />
Milan, Italy<br />
171. Role of CREB in the prodynorphin gene expression regulation by MDMA<br />
Di Benedetto Manuela, Porticella E, D´Addario C, Candeletti S, Romual<strong>di</strong> P<br />
Dept of Pharmacology - University of Bologna - via Irnerio 48, 40126 BOLOGNA<br />
172. 3,4-methylen<strong>di</strong>oxymethamphetamine (ecstasy) induces formation of reactive<br />
oxygen species and tau protein phosphorilation in the hippocampus<br />
Busceti Carla L. 1 , Biagioni F. 1 , Riozzi B. 1 , Storto M. 1 , Battaglia G. 1 , Fornai F. 1,3 Bruno V. 1,5 ,<br />
Nicoletti F. 1,5<br />
1 I.N.M. Neuromed, Pozzilli, Italy; 2 Dept. of Neuropathol., Univ. of Amsterdam, The<br />
Netherland; 3 Dept. of Hum. Morphol. and Applied Biol., Univ. of Pisa, Italy; 4 SienaBiotech,<br />
Siena, Italy; 5 Dept. of Hum. Physiol. and Pharmacol., Univ. “La Sapienza”, Rome, Italy<br />
97<br />
173. Pharmacological and toxicological properties of Smart Drugs<br />
Oteri A. a , Calapai G. a , Pichini S. b , Zuccaro P. b , Palmi I. b , Caputi A.P. a,c<br />
a Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina<br />
b Istituto Superiore <strong>di</strong> Sanità, Rome. c IRCCS Centro Neurolesi ‘‘Bonino-Pulejo’’, Messina, Italy<br />
Faramacologia dell'apparato <strong>di</strong>gerente<br />
Poster 174 – 186<br />
174. Inhibitory modulation of the non-adrenergic non-cholinergic relaxation of the rat<br />
gastric fundus by nociceptin/orphanin FQ and related peptides<br />
Currò Diego, De Marco T., Martucci D., Preziosi P.<br />
Institute of Pharmacology, School of Me<strong>di</strong>cine, Catholic University of the Sacred Heart, Rome,<br />
Italy<br />
175. Nociceptin/orphanin FQ prevents gastric damage induced by acute stress in the rat<br />
by acting in the periphery<br />
Morini Giuseppina a , Gran<strong>di</strong> D. a , Solinghi E. a , Guerrini R. b , Polidori C. c , Massi M. c<br />
a Department of Human Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of Parma,<br />
PARMA; b Department of Pharmaceutical Sciences and Biotechnology Center, University of<br />
Ferrara, Ferrara; c Department of Experimental Me<strong>di</strong>cine and Public Health, University of<br />
Camerino, Camerino, Italy<br />
pag_dx.indd 1 30/05/2007 4.27.57
176. Gastroprotective effects of the selective histamine H 3 receptor agonists methimepip<br />
and immethri<strong>di</strong>ne<br />
1 Adami Maristella, 1 Guaita E., 2 De Esch I.J.P., 2 Leurs R., 3 Stark H., 1 Coruzzi G.<br />
1 Department of Human Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of Parma,<br />
Italy; 2 LACDR, Department of Me<strong>di</strong>cinal Chemistry, Vrije Universiteit Amsterdam, The<br />
Netherlands; 3 Institut für Pharmazeutische Chemie, J W Goethe-Universität, Frankfurt,<br />
Germany<br />
177. The gastric effect of UFP 112, a new NOP receptor agonist, in physiologiacl and<br />
pathological con<strong>di</strong>tions<br />
Petrella Carla a , Agostini S. a , Broccardo M. a , Guerrini R. b , Improta G. a , Morini G. c<br />
a Dept. Human Physiology and Pharmacology University of Rome “La Sapienza”, b Dept.<br />
Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, c Dept. of Human<br />
Anatomy, Pharmacology and Forensis Me<strong>di</strong>cine, University of Parma –ITALY<br />
178. Effects of cyclooxygenase inhibitors on molecular mechanisms implicatd in gastric<br />
ulcer healing<br />
Colucci Rocchina 1 , Ghisu N. 1 , Antonioli L. 1 , Fornai M. 1 , Bernar<strong>di</strong>ni N. 2 , Ippolito C. 2 , Natale G. 2 ,<br />
Del Tacca M. 1 , Blan<strong>di</strong>zzi C. 1<br />
1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, 2 Department<br />
of Human Morphology and Applied Biology, University of Pisa, Italy<br />
98<br />
179. Dual effects of ticlopi<strong>di</strong>ne during formation and healing of ethanol-induced gastric<br />
lesions in the rat: comparison with aspirin<br />
Rapetti D. 1 , Guidobono F. 2 , Soglian A. 3 , Locatelli V. 1 , De Luca V. 2 , Sibilia V. 2<br />
1 Department of Experimental Me<strong>di</strong>cine, University of Milano- Bicocca, Monza, Italy<br />
2 Department of Pharmacology, Chemotherapy and Me<strong>di</strong>cal Tossicology, University of Milan,<br />
Italy<br />
3 Me<strong>di</strong>cal Department, Pharmaceutical Division, Bayer HealthCare, Milan, Italy<br />
180. Involvement of PKC in the adaptive changes of opioid receptos in the myenteric<br />
plexus after chronic sympathetic denervation<br />
1 Zanetti Elena, 1 Oldrini R., 2 Pascale A., 1 Canciani L., 1 Giuliani D., 2 Ama<strong>di</strong>o M., 3 Chiaravalli A.,<br />
1 Giaroni C., 1 Lecchini S., 1 Frigo G.<br />
1 Clinical and Applied Pharmacology Interuniversity Centre, University of Insubria and<br />
University of Pavia; 2 Experimental and Applied Pharmacology Dept, University of Pavia; 3 Dept.<br />
of Surgical Pathology Ospedale <strong>di</strong> Circolo of Varese<br />
181. Altered expression and phosphorylation of NMDA NR1 subunits in the myenteric<br />
plexus during hypoxia-hypoglicaemia<br />
1 Giaroni Cristina, 1 Zanetti E., 1 Giuliani D., 1 Oldrini R., 1 Bianchi F., 1 Moro E., 2 Trinchera M.,<br />
1 Crema F., 1 Lecchini S., 1 Frigo G.<br />
1 Clinical and Applied Pharmacology Interuniversity Centre, Universities of Insubria and Pavia,<br />
2 Department of Experimental and Clinical Biome<strong>di</strong>cal Sciences, University of Insubria<br />
182. Melatonin reverses LPS-induced gastro-intestinal motility <strong>di</strong>sturbances through the<br />
inhibition of oxidative stress<br />
De Filippis Daniele 1 , Esposito G. 3 , D’Amico A. 1 , De Man J.G. 2 , De Winter B.Y. 2 , Steardo L. 3 ,<br />
Iuvone T. 1<br />
1<br />
Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples<br />
Federico II, Via D. Montesano 49, 80131 Naples, Italy. 2 Division of Gastroenterology, Faculty<br />
of Me<strong>di</strong>cine, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.<br />
3 Department of Human Physiology and Pharmacology “Vittorio Erspamer”Faculty of Pharmacy<br />
University of Rome “La Sapienza” Piazza A. Moro 5, 00151 Roma (Italy)<br />
pag_sx.indd 1 30/05/2007 4.29.17
183. The cannabinoid WIN 55212 inhibits pancreatic amylase secretion via cholinergic<br />
suppression<br />
Agostini Simona, Broccardo M., Improta G., Petrella C., Linari G.<br />
Dept. of Human Physiology and Pharmacology. University “La Sapienza”, Rome<br />
184. Sera of celiac patients with neurological <strong>di</strong>sorders evoke a mitochondrial-dependent<br />
apoptosis in human SH-Sy5Y neuroblastoma cells<br />
Cervio Elisabetta*, Volta U.°, Verri M.*, Boschi F.*, Pastoris O.*, Granito A.°, De Giorgio R.^,<br />
Tonini M.*<br />
*Dept of Phys & Pharm Sci, Univ Pavia; Dept of °Int Med, Car<strong>di</strong>oangiol, Hepatol & ^Int Med &<br />
Gastroenterol, Univ of Bologna, Italy<br />
185. Expression and function of the bradykinin B1 receptor in normal and inflamed<br />
human gallbladder<br />
Andre Eunice 1 , Gazzieri D. 1 , Bardella E. 1 , Ferreira J. 3 , Mori M.A. 4 , Bader M. 4 , João B.C. 5 , De<br />
Giorgio R. 6 , Corinaldesi R. 6 , Geppetti P. 1 , Trevisani M. 1<br />
1 Pharmacology Unit, University of Ferrara, 3 Dep. of Chemistry, Universidade Federal de Santa<br />
Maria, 4 Max Delbrück Center for Molecular Me<strong>di</strong>cine, Berlin-Buch, 5 Dep. of Pharmacology,<br />
Universidade Federal de Santa Catarina, Florianópolis, 6 Dep. Int. Med. and Gastroent.,<br />
University of Bologna<br />
186. A community pharmacies survey on prevalence of constipation and risk factors for<br />
laxative use in the local health <strong>di</strong>stricts of Verbania and Messina<br />
Morreale Ilaria (1) , Salvo F. (1) , Polimeni G. (1) , Vighi E. (2) , Poggi L. (2) , Dossi G. (2) , Rossitto<br />
A. (3) , De Sarro A. (1) , Calapai G. (1) , Caputi A.P. (1)<br />
(1) Dep. Clin Experim Med and Pharmacol, University of Messina, Italy. (2) Local Health District<br />
N. 14 (Verbano/Cusino/Ossola), Verbania, Italy<br />
99<br />
Farmacologia del metabolismo e del sistema endocrino<br />
Poster 187 – 195<br />
187. Exenatide achieved equivalent glycemic control to insulin glargine with weight<br />
reduction, independently from baseline BMI, in metformin and sulfonylurea-treated<br />
type-2 <strong>di</strong>abetes<br />
Gentilella Raffaella 4 ; Heine R.J. 1 ; Van Gaal L.F. 2 ; Johns D. 3 ; Mihm .J. 3 ; Widel M.H. 3 ; Brodows<br />
R.G. 3<br />
1 Diabetes Center, Department of Endocrinology, VU University Me<strong>di</strong>cal Center, Amsterdam,<br />
The Netherlands; 2 Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of<br />
Me<strong>di</strong>cine, University Hospital Antwerp, Belgium; 3 Lilly Research Laboratories, Eli Lilly and<br />
Company, In<strong>di</strong>anapolis, IN, USA; 4 Eli Lilly Italy, Florence, Italy<br />
188. Effects of exenatide compared with twice-daily biphasic insulin aspart in patients<br />
with type 2 <strong>di</strong>abetes using metformin and a sulphonylurea<br />
Gentilella Raffaella 5 , Nauck M.A. 1 , Duran Garcia S. 2 , Kim D. 3 , Johns D. 4 , Festa A. 4 , Trautmann<br />
M. 4<br />
1 Clinical Diabetology, Diabeteszentrum Bad Lauterberg, Germany, 2 Cátedra de Endocrinología,<br />
Hospital de Valme, Seville, Spain, 3 Amylin Pharmaceuticals, Inc., San Diego, United States,<br />
4 Lilly Research Laboratories, Eli Lilly and Company, In<strong>di</strong>anapolis, United States; 5 Eli Lilly Italy,<br />
Florence, Italy<br />
pag_dx.indd 1 30/05/2007 4.30.39
189. A comparison of exenatide and insulin glargine in patients using a single oral<br />
anti<strong>di</strong>abetic agent<br />
Gentilella Raffaella 5 ,Barnett A.H. 1 , Trautmann M. 2 , Burger J. 3 , Johns D. 3 , Kim D. 4 , Brodows<br />
R. 3 , Festa A. 2 , Roberts A. 2<br />
1 Department of Diabetes/Endocrinology, Birmingham Heartlands Hospital, United Kingdom,<br />
2 Eli Lilly and Company, Hamburg, Germany, 3 Eli Lilly and Company, In<strong>di</strong>anapolis, United<br />
States, 4 Amylin Pharmaceuticals, Inc., San Diego, United States; 5 Eli Lilly Italy, Florence, Italy<br />
190. Safety and efficacy of exenatide over 16 weeks in patients with type 2 <strong>di</strong>abetes<br />
mellitus using a thiazoli<strong>di</strong>ne<strong>di</strong>one with or without metformin<br />
Gentilella Raffaella 6 , Zinman B. 1 , Hoogwerf B. 2 , Duran Garcia S. 3 , Milton D. 4 , Giaconia J. 4 , Kim<br />
D. 5 , Trautmann M. 7 , Brodows R. 4<br />
1 Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada, 2 Department of<br />
Endocrinology, Cleveland Clinic Foundation, Cleveland, USA, 3 Cátedra de Endocrinología,<br />
Hospital de Valme, Sevilla, Spain, 4 Eli Lilly and Company, In<strong>di</strong>anapolis, USA, 5 Amylin<br />
Pharmaceuticals, Inc., San Diego, USA, 6 Eli Lilly Italy, Florence, Italy, 7 Eli Lilly and Company,<br />
Hamburg, Germany<br />
191. Beta-cell function is markedly reduced in women with previous gestational <strong>di</strong>abetes<br />
Canu Silvia 1 , Franconi F. 1 , Tesi F. 2 , Seghieri G. 2<br />
1 Dpt. of Pharmacology, University of Sassari, Italy. 2 Dpt. of Internal Me<strong>di</strong>cine, Spedali Riuniti,<br />
Pistoia<br />
100<br />
192. Concentration of brain natriuretic peptide in women with gestational <strong>di</strong>abetes<br />
2 Campesi Ilaria,<br />
1 Tesi F., 1 Gironi A. 2 Canu S., 2 De Bellis A., 1 Anichini R., 1 Seghieri G.,<br />
2 Franconi F.<br />
1 Dpt. of Internal Me<strong>di</strong>cine, Spedali Riuniti, Pistoia, 2 Dpt. of Pharmacology, University of<br />
Sassari, Italy<br />
193. Biochemical mechanisms underlying endocannabinoid dysregulation in the pancreas<br />
and a<strong>di</strong>pose tissue of high fat <strong>di</strong>et-fed mice<br />
Matias Isabelle 1 , Starowicz K. 1 , Cristino L. 2 , Racioppi A. 1 , Di Marzo V. 1<br />
1,2 Endocannabinoid Research Group, 1 Institute of Biomolecular Chemistry and 2 Institute of<br />
Cybernetics, Consiglio Nazionale delle Ricerche, Pozzuoli (NA), Italy<br />
194. Ghrelin and des-acyl ghrelin inhibit isoproterenol-induced lipolysis in rat a<strong>di</strong>pocytes<br />
through activation of phospho<strong>di</strong>esterase 3B<br />
Baragli Alessandra, Ghè C., Arnoletti E., Muccioli G.<br />
Division of Pharmacology, Department of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine,<br />
University of Turin, Turin, Italy<br />
195. Pharmacological modulation of metabolic, hormonal, and inflammatory alterations<br />
in an experimental model of hepatic steatosis<br />
1 Iacono Anna, 1,4 Esposito E., 1 Mattace Raso G., 2 Bianco G., 3,4 Cuzzocrea S., 1 Meli R.<br />
1 Department of Experimental Pharmacology, University of Naples “Federico II”, Naples;<br />
2 Department of Pharmaceutical Sciences, University of Salerno; 3 Department of Clinical and<br />
Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine, University of Messina, Messina;<br />
4 IRCCS Centro Neurolesi "Bonino-Pulejo," Messina, Italy<br />
pag_sx.indd 1 30/05/2007 4.34.12
Farmacologia della <strong>di</strong>sfunzione erettile<br />
Poster 196 – 201<br />
196. Involvement of mitogen-activated protein kinases (MAPKS) during testicular<br />
ischemia-reperfusion injury in nuclear factor-kB knock-out mice<br />
Minutoli Letteria 1 , Bitto A. 1 , Polito F. 1 , Fiumara T. 1 , Squadrito F. 1 , Mioni C. 2 , Antonuccio P. 3 ,<br />
Romeo C. 3 , Marini H. 4 , Guarini S. 2 Caputi A. P. 1 , Altavilla D. 1 .<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Univ of Messina 2 Dept<br />
of of Biomed Sci, Univ of Modena and Reggio Emilia, 3 Department of Med and Surg Pe<strong>di</strong>atric<br />
Sci, 4 Dept of Biochem, Physiol and Nutr Sci, University of Messina, Italy<br />
197. Stimulation of dopamine receptors in the paraventricular nucleus of the<br />
hypothalamus of male rats induces penile erection and increases extra-cellular<br />
dopamine in the nucleus accumbens: involvement of central oxytocin<br />
Succu Salvatora, Sanna F., Melis T., Argiolas A., Melis M.R.<br />
Bernard B. Bro<strong>di</strong>e Department of Neuroscience, University of Cagliari, Italy<br />
198. Influence of a cannabinoid CB 1 receptor antagonist, SR141716, on sexual behavior<br />
of male rats<br />
Zanoli Paola, Zavatti M., Montanari C., Rivasi M., Poggioli R., Benelli A.<br />
Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, University of Modena and<br />
Reggio Emilia, Modena, Italy<br />
199. Hydrogen sulfide (H 2 S) relaxes human and rabbit corpus cavernosum in vitro<br />
Romina Nassini 1 , Patacchini R. 2 , Materazzi S. 1 , Mondaini N. 1 , Natali A. 1 , Geppetti P. 1 ,<br />
Harrison S. 1<br />
1 Department of Critical Care Me<strong>di</strong>cine & Surgery, University of Florence, Florence, Italy; and<br />
2 Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy; Florence, Italy<br />
101<br />
200. Eurycoma longifolia improves copulatory activity of sexually sluggish rats<br />
Montanari Caterina, Zavatti M., Zanoli P., Baral<strong>di</strong> M.<br />
Dept. of Biome<strong>di</strong>cal Sciences, Section of Pharmacology and National InterUniversity<br />
Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and<br />
Reggio Emilia, Modena, Italy<br />
201. The tight-skin mice as a genetic model of Peyronie's-like <strong>di</strong>sease<br />
1,2 d’Emmanuele <strong>di</strong> Villa Bianca Roberta, 1,2 Sorrentino R., 3 Lungarella G., 1 Longo N., 1 Imbimbo<br />
C. 1 Mirone V. 1,2 Cirino G.<br />
1 Center for Preclinical and Clinical Research in Sexual Me<strong>di</strong>cine (CIRMS), 2 Department of<br />
Experimental Pharmacology, University of Naples Federico II,<br />
3 Departement of<br />
Physiopathology, Experimental Me<strong>di</strong>cine and Public Health, University of Siena<br />
Farmacologia dell'infiammazione<br />
Poster 202 – 213<br />
202. Pharmacological activity of selective COX-1 and COX-2 inhibitors in endothelial cells<br />
Sala Angelo, Bolego C., Buccellati C., Folco G.,<br />
Department of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan<br />
Italy<br />
203. Role of FGFR1 in the angiogenic response induced by PGE2<br />
Finetti Federica, Ziche M., Donnini S.<br />
Pharmacology section, Department of Molecular Biology, University of Siena<br />
pag_dx.indd 1 30/05/2007 4.36.33
204. Time course of brain PGE 2 level and synthesis pathway in LPS- fevered rats<br />
Di Matteo Anna, Bartella C., Mangano G., Apicella C., Mancini F., Coletta I., Guglielmotti A.,<br />
Polenzani L.<br />
Angelini Farmaceutici – ACRAF S.p.A Piazzale della Stazione S.Palomba-Pomezia Italy<br />
205. Brain Prostanoids profile in control and LPS-treated rats<br />
Bartella Cristina, Garrone B.e, Basta F., De Santi S., Vitiello M., Coletta I., Guglielmotti A.,<br />
Polenzani L.<br />
Angelini Farmaceutici – ACRAF S.P.A Piazzale della Stazione S.Palomba-Pomezia Italy<br />
206. Cysteinyl leukotrienes in human endothelial cells: synthesis and activities<br />
Sala Angelo , Carnini C., Accomazzo M.R., Borroni E., Vitellaro-Zuccarelli L., Folco G., Rovati<br />
G.<br />
Department of Pharmacological Sciences, Department of Biomolecular Sciences and<br />
Biotechnology, and Center for Car<strong>di</strong>opulmonary Pharmacology, University of Milan, 20133<br />
Milan, Italy<br />
207. Nitric-oxide scavenging properties of novel organic compounds containing cobalt<br />
(II) and ruthenium (III)<br />
1 Cantore Miriam, 2 Valtancoli B., 3 Cinci L., 2 Bencini A., 1 Ciuffi M., 1 Failli P.<br />
Depts. of: 1 Preclinical & Clinical Pharmacology,<br />
2 Chemistry and 3 Anatomy, Histology &<br />
Forensic Me<strong>di</strong>cine, University of Florence, Italy<br />
102<br />
208. Inhibition of nitric oxide pathway by an acetonic extract from Feijoa sellowiana<br />
berg. fruits<br />
Rossi Antonietta 1,2 , Pergola C. 1 , Formisano C. 3 , Guerriere L. 3 , Sautebin L. 1<br />
1 Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy;<br />
2 IRCCS Centro Neurolesi “Bonino-Pulejo”, University of Messina, Messina, Italy; 3 Department<br />
of Chemistry of Natural Products, University of Naples Federico II, Naples, Italy<br />
209. NCX 2057, a nitric oxide-derivative of ferulic acid, exerts anti-inflammatory activity<br />
in in-vitro and in-vivo models<br />
Ronchetti Daniela, Borghi V., Bion<strong>di</strong> S., Impagnatiello F.<br />
Nicox Research Institute, Bresso, Milan, Italy<br />
210. NCX 4040, a nitric oxide-donating aspirin derivative with improved antiinflammatory<br />
properties<br />
Anzellotti Paola, Di Francesco L., Tacconelli S., Patrignani P.<br />
Department of Me<strong>di</strong>cine and Center of Excellence on Aging, School of Me<strong>di</strong>cine, “G.<br />
d’Annunzio” University; †“G. d’Annunzio” University Foundation, Ce.S.I<br />
211. Evidence of cytokines levels modulation in rat serum exerted by Iacvita, a new<br />
antioxidant compound<br />
Ricchi Lucia, Corsi L., Geminiani E., Baral<strong>di</strong> M.<br />
Dip. Scienze Biome<strong>di</strong>che Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Modena e Reggio Emilia<br />
CINSPAN Consorzio Interuniversitario Nazionale per lo <strong>Stu<strong>di</strong></strong>o dei Principi Attivi Naturali<br />
212. Rapid release of annexin A1 following heat-shock response in LPS-stimulated<br />
macrophages<br />
Festa Michela, Parente L., Flower R. J. * , Perretti M. * , D’Acquisto F. * , Ercolino S.F.<br />
Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy. * William Harvey<br />
Research Institute, Dept. of Biochemical Pharmacology, Charterhouse Square, London,<br />
England<br />
pag_sx.indd 1 30/05/2007 4.38.13
213. Estrogen receptor antagonist ICI 182,780 inhibits the anti-inflammatory effect of<br />
glucocorticoids<br />
1,2 Salvatore Cuzzocrea, 3 Bruscoli S., 1 Crisafulli C., 1,2 Mazzon E., 3 Agostini M., 1 Muià C.,<br />
2,4 Esposito E.,<br />
3 Di Virgilio R.,<br />
4 Meli R.,<br />
5 Vegeto E.,<br />
5 Maggi A.,<br />
3 Riccar<strong>di</strong> C.<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina,<br />
Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy; 3 Department of Cinical and<br />
Experimental Me<strong>di</strong>cine, Pharmacology, University of Perugia, Italy;<br />
4 Department of<br />
Experimental Pharmacology, University of Naples “Federico II”, Naples Italy; 5 Department of<br />
Pharmacological Sciences, University of Milan, Italy<br />
Chemioterapia antibatterica, antivirale e antineoplastica<br />
Poster 214 – 228<br />
214. Synergistic cytotoxicity and pharmacogenetics of gemcitabine and ZD6474 in<br />
bladder cancer cell lines<br />
Mey Valentina, Elisa G., Nannizzi S., Ricciar<strong>di</strong> S., Danesi R., Del Tacca M.<br />
Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine,<br />
University of Pisa<br />
215. Synergistic cytotoxycity, inhibition of AKT and C-KIT phosphorylation, modulation of<br />
gene expression by sorafenib and gemcitabine in human pancreatic cancer cells<br />
Ricciar<strong>di</strong> Simona, Giovannetti E. , Nannizzi S., Mey V., Pasqualetti G., Danesi R., Del Tacca<br />
M.<br />
Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />
Pisa<br />
216. Inhibition of STAT 3 increases doxorubicin sensitivity in a human metastatic breast<br />
cancer cell line<br />
Roberta Molteni, Ravizza R., Garibol<strong>di</strong> M.B., Monti E.<br />
Dept. of Structural and Functional Biology, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> dell’Insubria<br />
103<br />
217. In vitro study of the interaction between gemcitabine and sorafeniv in non small<br />
cell lung cancer (NSCLC) A549 cell line<br />
Pasqualetti Giuseppe, Ricciar<strong>di</strong> S., Nannizzi S., Mey V., Elisa G., Danesi R., Del Tacca M.<br />
Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine - University of<br />
Pisa<br />
218. In vitro and in vivo antineoplastic effects of a novel platinum bioconjugate using a<br />
biocompatible polymeric matrix<br />
Garibol<strong>di</strong> Marzia Bruna, Gabano E. 1 , Sparnacci K. 1 , Laus M. 1 , Osella D. 1 , Ravizza R., Molteni<br />
R., Monti E.<br />
DBSF – Pharmacology Section, University of Insubria, Busto Arsizio (VA). 1 Dipartimento <strong>di</strong><br />
Scienze dell’Ambiente e della Vita, Università del Piemonte Orientale “A. Avogadro”,<br />
Alessandria<br />
219. Toxicological evaluation of mepacrine and interferon alfa-2A on U87-MG and Vero<br />
cell colture<br />
Coppi Andrea, Baggio G., Bruni E. Rossi T.<br />
University of Modena and Reggio Emilia- Italy: Departmentof Biome<strong>di</strong>cal Sciences-<br />
Section of Pharmacology; 287 G. Campi st 41100 Modena Italy<br />
pag_dx.indd 1 30/05/2007 4.39.14
220. Pro-oxidant and antitumor effects of curcumin and N-ethylmaleimide in the<br />
HA22T/VGH model of Overt hepatocellular carcinoma<br />
Carina Valeria, Labbozzetta M., Poma P., Alaimo A., Maurici A., Inguglia L., Notarbartolo M.,<br />
D’Alessandro N.<br />
Dipartimento <strong>di</strong> Scienze Farmacologiche, Università <strong>di</strong> Palermo<br />
221. HDAC inhibitors restore the p53 pathway in neuroblastoma cells<br />
Gnemmi Ilaria, Condorelli F., Genazzani A.A., Canonico P.L.<br />
DiSCAFF&DFB Center, Università del Piemonte Orientale, Novara, Italy<br />
222. Temperature influence on cellular uptake, DNA platination and antiproliferative<br />
activity of platinum(II) drugs<br />
Colangelo Donato a , Gabano E. b , Osella D. b , Viano I. a<br />
a Dept. Me<strong>di</strong>cal Sciences, Via Solaroli 17 I-28100 Novara, b Dept. of Ambiental and Life<br />
Sciences, via Bellini 25/G, I-15100 Alessandria, Università del Piemonte Orientale “A.<br />
Avogadro”, Italy<br />
223. Inhibition of P-GP/ATPASE activity of rat small intestine membrane vesicles by the<br />
novel, <strong>di</strong>hydropyri<strong>di</strong>ne MDR REVERTER DP7<br />
Alderighi Daniela, Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi F., Shah A.,<br />
Kawasae M., Motohashi N., Molnar J., Sgaragli G.<br />
Dipartimento <strong>di</strong> scienze biome<strong>di</strong>che, Università Degli <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena via A. Moro 2, 53100<br />
Siena<br />
104<br />
224. High energy shock waves increase paclitaxel efficacy in a syngenic model of breast<br />
cancer<br />
Canaparo Roberto 1,2 , Serpe L. 2 , Ean<strong>di</strong> M. 2 , Zara G.P. 2 , Berta L. 1 , Frairia R. 1<br />
1 Department of Clinical Pathophysiology, University of <strong>Torino</strong>, <strong>Torino</strong>, Italy. 2 Department of<br />
Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of <strong>Torino</strong>, <strong>Torino</strong>, Italy<br />
225. Evaluation of synthetic "tubulysin U" induced cytotoxycity in HL60, C6, PC12 and<br />
ECV304 cell lines<br />
Manca Ilaria a , Sani M. b,c , Sanna A. a , Fossati G. b , Lazzari P. a , Huguenot F. b , Pani L. a,d , Zanda<br />
M. b<br />
a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />
(CA), Italy. b C.N.R. Istituto <strong>di</strong> Chimica del Riconoscimento Molecolare, Via Mancinelli 7,<br />
20131 Milano, Italy. c KemoTech srl, Unità Operativa <strong>di</strong> Milano, Via Mancinelli 7, 20131 Milano,<br />
Italy. d C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o Neuroscienze<br />
PharmaNess S.c.a r.l.<br />
226. Anthocyani<strong>di</strong>ns modulate the cytotoxicity of irinotecan and oxaliplatin in human<br />
colon adenocarcinoma cells<br />
Cvorovic Jovana, Candussio L., Maestro A., Bartoli F., Decorti G.<br />
Department of Biome<strong>di</strong>cal Sciences, University of Trieste, Via Giorgieri 7, Trieste<br />
227. Preliminary results on antiproliferative effect of new deacetilase inhibitors on<br />
human leukemia cell lines<br />
Vitali Federica a , Turriziani M. b , D’Alfonso R. b , Lombardo M. b , Valenti S. c , Mai A. c , Tita B. a<br />
a Department of Human Physiology and Pharmacology, University of Rome “Sapienza”.<br />
b Department of Internal Me<strong>di</strong>cine, University of Rome “Tor Vergata”. c Department of<br />
Pharmaceutical <strong>Stu<strong>di</strong></strong>es, University of Rome “Sapienza”<br />
228. Topical administration of resveratrol as pre- and antineoplastic agent<br />
Berta Giovanni N., Mognetti B., Barberis A., Marinos L., Di Carlo F.<br />
Department of Clinical and Biological Sciences, University of Turin, I-10043 Orbassano, Italy<br />
pag_sx.indd 1 30/05/2007 4.41.01
Farmacologia clinica e sperimentazione clinica dei farmaci<br />
Poster 229 – 239<br />
229. Effect of topiramate treatment in a patient affected ny symptomatic trigeminal<br />
neuralgia<br />
Gallelli Luca 1 , Siniscalchi A. 2 , Borner Perrone I. 1 , Davoli A. 1 , De Sarro G. 1<br />
1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Italy.<br />
2 Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy<br />
230. Pharmacokinetics of tramadol and of ITS metabolite N-desmethyltramadol in<br />
fasting and fed horses, after single oral administration<br />
Buti Deanna, Saccomanni G.*, Sgorbini M., Mengozzi G., Manera C.* Giorgi M.<br />
Departments of Veterinary Clinics V.le delle Piagge 2 56124 Pisa, Italy. *Pharmaceutical<br />
Science Via Bonanno 6 56126 Pisa, Italy<br />
231. Administration of oral sustained-release tablet formulation of tramadol in horses:<br />
pharmacokinetics of the parental drug and of n-desmethyltramadol<br />
Magnani Francesca, Saccomanni G.*, Casini L.**, Soldani G., Manera C.*, Giorgi M.<br />
Departments of Vetrinary Clinics V.le delle Piagge 2 56124 Pisa, *Pharmaceutical Science V.<br />
Bonanno 6 56126 Pisa and **Animal Productions, S. Piero a Grado, 56010 Pisa, Italy<br />
232. High homocysteine plasma levels in patients treated with antiepileptic drugs<br />
Gallelli Luca 2 , Liotti A. 2 , Siniscalchi A. 1 , Davoli A. 2 , Marigliano N.M. 2 , De Sarro G. 2<br />
1 Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy<br />
2 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Italy<br />
105<br />
233. Pharmakinetics of indomethacian in chronic migraine patients after withdrawal of<br />
the overused combination of indomethacin, prochlorperazine, and caffeine<br />
Ferrari Anna, Gallesi D., Sances G.*, Pinetti D., Bertolini A., Sternieri E.<br />
Toxicology and Clinical Pharmacology Section, Headache Centre, University Centre for<br />
Adaptive Disorders and Headache, Section Modena II. University of Modena and Reggio<br />
Emilia, Italy<br />
*Headache Unit, IRCCS C. Mon<strong>di</strong>no, University of Pavia, Italy<br />
234. Variability of oral sumatriptan pharmacokinetics in migraine patients<br />
Coccia Ciro, Pinetti D., Bertolini A., Sternieri E., Ferrari A.<br />
Toxicology and Clinical Pharmacology Section, Headache Centre, University Centre for<br />
Adaptive Disorders and Headache, Section Modena II. University of Modena and Reggio<br />
Emilia, Italy<br />
235. Hormonal index of well-being in women affected by me<strong>di</strong>cation overuse headache<br />
(MOH)<br />
Monnazzi Paola, Simeoni S., Martelletti P.* , Patacchioli F.<br />
Romana.<br />
Dept Human Physiology and Pharmacology “V. Erspamer”, *Internal Me<strong>di</strong>cine, 2 nd School of<br />
Me<strong>di</strong>cine, University of Rome La Sapienza, Italy<br />
pag_dx.indd 1 30/05/2007 4.47.44
236. Long-term efficacy of antihypertensive therapy in old-age patients with essential<br />
hypertension<br />
Sigala Sandra 1,2 , Alicandri C. 1 , Parini F. 1,2 , Valenti L. P. 1 , Parrinello G. 3 , Spano P.F. 2<br />
1 Division of Me<strong>di</strong>cine, Istituto Clinico Città <strong>di</strong> Brescia, Brescia, Italy; 2 Section of Pharmacology,<br />
Dept of Biomed Sci and Biotec, University of Brescia Me<strong>di</strong>cal School, Brescia, Italy; 3 Me<strong>di</strong>cal<br />
Statistic Unit, Dept of Biomed Sci and Biotec, University of Brescia Me<strong>di</strong>cal School, Brescia,<br />
Italy<br />
237. The role of CYP3A5 in methadone methabolism: a case report<br />
De Fazio Salvatore 1 , Scordo M.G. 2 , Gallelli L. 1 , Marigliano N.M. 1 , Ferreri Ibbadu G. 1 , Rende P. 1 ,<br />
De Sarro G. 1<br />
1 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine, University of Catanzaro, Via T. Campanella 115, 88100 Catanzaro, Italy<br />
2 Department of Me<strong>di</strong>cal Sciences, Clinical Pharmacology; Uppsala University, Akademiska<br />
sjukhuset, Ing. 61, 75185 Uppsala, Sweden<br />
238. Management of lithium therapy during pregnancy<br />
Lampus Simona, Serio S., Chillotti C., Del Zompo M., Ardau R.<br />
Clinical Psychopharmacology Center, Section of Clinical Pharmacology, Department of<br />
Neurosciences "B. B. Bro<strong>di</strong>e", University of Cagliari<br />
106<br />
239. A new apomorphine formulation for oral administration<br />
Zara Gian Paolo 1 , Cattaldo S. 4 , Cavalli R. 2 , Calderoni S. 4 , Muntoni E. 1 , Gasco M.R. 5 , Mauro<br />
A. 3-4 , Ean<strong>di</strong> M. 1<br />
1 Dipartimento Anatomia Farmacologia e Me<strong>di</strong>cina Legale, 2 Dipartimento <strong>di</strong> Scienze e<br />
Tecnologia del Farmaco, 3 Dipartimento <strong>di</strong> Neuroscienze, Università <strong>di</strong> <strong>Torino</strong> Italy - 4 IRRCS<br />
Istituto Auxologico Italiano, Piancavallo Italy – 5 Nanovector s.r.l. <strong>Torino</strong> Italy<br />
Farmacovigilanza, farmacoepidemiologia e farmacoeconomia<br />
Poster 240 – 251<br />
240. Investigation on the opportunity in initiating treatment for hepatitis C virus (HCV)<br />
infection among drug users<br />
Mattioli Francesca, Montinaro E.*, Ducci E.*, Martelli A.<br />
Department of Internal Me<strong>di</strong>cine, Pharmacology Unit, University of Genoa, I-16132 Genoa,<br />
Italy<br />
*Valbisagno Drug Dependence Service (SerT) of Genoa<br />
241. Reports of adverse reactions to antibiotics in the Tuscan Pharmaresearch Database<br />
Tuccori Marco 1 , Montagnani S. 1 , Giustini Saffi E. 2 , Salvetti A. 2 , Blan<strong>di</strong>zzi C. 1 , Del Tacca M. 1<br />
1 Tuscan Regional Center for Pharmacovigilance - Division of Pharmacology and<br />
Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of Pisa – Pisa, Italy<br />
2 Italian Society of General Me<strong>di</strong>cine (SIMG) – Florence, Italy<br />
242. Retrospective evaluation of antidepressants side effects<br />
De Fazio Salvatore, Gareri P., Palleria C., Gallelli L., De Sarro G.<br />
Chair of Pharmacology, School of Me<strong>di</strong>cine, University “Magna Graecia” of Catanzaro, “Mater<br />
Domini” University Hospital, Via T. Campanella 115, 88100 Catanzaro, Italy<br />
243. Guidelines on the clinical use of clozapine<br />
Ligas Franca, Ardau R., Chillotti C., Del Zompo M.<br />
Clinical Psychopharmacology Centre, Section of Clinical Pharmacology, Department of<br />
Neurosciences “B.B. Bro<strong>di</strong>e”, University of Cagliari<br />
pag_sx.indd 1 30/05/2007 4.51.03
244. Observational study comparing the safety of typical and atypical antipsychotic drugs<br />
in patients affected by dementia with behavioural and psychological symptoms of<br />
dementia (BPSD)<br />
Capuano Annalisa, Potenza S., Ferrante L., Gallo M., Rinal<strong>di</strong> B., Filippelli A., Rossi F.<br />
Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “Leonardo Donatelli”. Center<br />
of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Me<strong>di</strong>cine and Surgery, Second<br />
University of Naples, Italy<br />
245. Prescribing pattern of Anti-Parkinson drugs in Southern Italy: cross-sectional<br />
analysis in the years 2003-5<br />
Trifirò Gianluca 1,5 , Savica R. 2 , Morgante L. 2 , Tari M. 3 , Moretti S. 3 , Vanacore N. 4 , Spina E. 1,5 ,<br />
Arcoraci V. 1 , Caputi A.C. 1,5<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Pharmacology Unit,<br />
University of Messina, Italy; 2 Department of Neuroscience, Psychiatry and Anaesthesiology,<br />
University of Messina, Italy; 3 Caserta-1 Local Health Service, Caserta – Italy; 4 National<br />
Centre for Epidemiology Surveillance and Health Promotion. National Institute of Health,<br />
Rome, Italy; 5 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy<br />
246. Use of herbal products in children: risks and benefits<br />
Loizzo Stefano 1,2 , Loizzo A.L. 3 , Capasso A. 4 , Loizzo A. 1<br />
1 Dept of Drug Research and Evaluation and 2 Dept of Cell Biology and Neurosciences, Istituto<br />
Superiore <strong>di</strong> Sanita’, Roma, Italy; 3 Dept of Pae<strong>di</strong>atric Neuropsychiatry, University of Roma Tor<br />
Vergata, Roma, Italy, 4 Dept of Pharmacology, University of Salerno, Salerno, Italy<br />
247. Knowledge and use of herbal drugs in pregnancy<br />
1 Micheli Lucia, 1 Nencini C., 1 Franchi G.G., 2 Urso R. 1, 2 , Giorgi G.<br />
1 Department of Pharmacology “Giorgio Segre”, University of Siena. 2 Centro Regionale <strong>di</strong><br />
Farmacovigilanza, Area Vasta Sud- Est (Siena), Regione Toscana<br />
107<br />
248. Drugs and herbal products in hospital practice: use and potential interactions<br />
Stocco Andrea 1 , Gallo U. 2 , Bano F. 2 , Bin A. 1 , Grion A. M. 2 , Ori C. 1 , Gaion R. M. 1 , Giron M.C. 1<br />
1 Department of Pharmacology and Anesthesiology, University of Padova. 2 Department of<br />
Pharmaceutical Care, ULSS 16 – Padova<br />
249. Knowledges about herbal products among subjects on warfarin therapy and<br />
patient-physician relationship<br />
Benoni Giuseppina 1 , Cuzzolin L. 1 , Francini-Pesenti F. 2 , Zaffani S. 1 , Brocadello F. 2 , Pengo V.<br />
3 , Bassi A. 4<br />
1 Department of Me<strong>di</strong>cine & Public Health-Section of Pharmacology, University of Verona,<br />
Italy; 2 Clinical Nutrition Unit, Hospital of Padua, Italy; 3 Clinical Car<strong>di</strong>ology-Thrombosis Centre,<br />
University of Padua, Italy; 4 Department of Clinical and Experimental Me<strong>di</strong>cine, University of<br />
Verona, Italy<br />
250. Attitudes, knowledge and use of herbal products among pregnant women: a pilot<br />
survey in Tuscany<br />
Vannacci Alfredo, Lapi F., Morsuillo M., Meschini M., Cipollini F. c , Di Pirro M., Cecchi E. a ,<br />
Banchelli G., Firenzuoli F., Mugelli A.<br />
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy a Emergency<br />
Department, Prato Hospital, ASL 4, Italy; b Centre of Natural Me<strong>di</strong>cine, ASL 11, Empoli, Italy;<br />
c Department of Statistical Sciences, University of Florence, Italy<br />
251. Surveillance and information on herbal me<strong>di</strong>cines use of in pregnancy in the Sicily<br />
Region<br />
Pieratti Antonella¹, Calapai G.¹, Corsello S.², Mirabile M.², Fava G.¹, Caputi A. P.¹<br />
1)<br />
Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina.<br />
2) U.O.C. of Ginecology and Obstetrics, Hospital S.S. Salvatore, Paternò, Catania<br />
pag_dx.indd 1 30/05/2007 4.52.45
Tossicologia sperimentale e clinica<br />
Poster 252 – 265<br />
252. Neurochemical modulation and behavioural change after neonatal administration of<br />
pyrethroids in animal model<br />
Nasuti Cinzia Carla 1 , Gabbianelli R. 2 , Di Stefano A. 3 , Cantalamessa F. 1<br />
1 Department of Experimental Me<strong>di</strong>cine and Public, University of Camerino, 62032 Camerino<br />
(MC).<br />
2 Department of Biology M.C.A., University of Camerino, 62032 Camerino (MC).<br />
3 Department of Drug Science, University of “G. D’Annunzio”, 66100 Chieti (CH)<br />
253. Role of brain renin angiotensin system in the acute hypertensive response to<br />
intracerebroventricular cadmium<br />
Varoni M.Vittoria, Palomba D., Anania V., Demontis M.P.<br />
D.B.A - Division of Pharmacology, Faculty of Veterinary Me<strong>di</strong>cine – University of Sassari<br />
254. Cancer chemoprevention: manipulation of xenobiotic metabolizing enzymes by<br />
glucoraphasatin and glucoraphasatin and glucoraphenin found in Brassicaceae<br />
Bonamassa Barbara 1 , Barillari J. 2 , Canistro D. 1 , Pozzetti L. 1 , Sapone A. 1 , Iori R. 2 , Biagi G.L. 1<br />
, Paolini M. 1<br />
1 Department of Pharmacology, Molecular Toxicology Unit, Alma Mater <strong>Stu<strong>di</strong></strong>orum - University<br />
of Bologna, Via Irnerio 48 - 40126 Bologna, Italy. 2 Agricultural Research Council - Research<br />
Institute for Industrial Crops (CRA-ISCI), via Corticella 133, Bologna, Italy<br />
108<br />
255. Effects of PCB101, PCB118, PCB138 and PCB153 alone and in mixture in MCF-7<br />
breast cancer cells: possible mechanism of action<br />
Chiesara Enzo, Marabini L., Ra<strong>di</strong>ce S.<br />
Department of Pharmacology, Chemoterapy and Me<strong>di</strong>cal Toxicology “E. Trabucchi”, University<br />
of Milan, Via Vanvitelli 32, 20129, Milan<br />
256. Does acetylsalycilic acid interfere with liver <strong>di</strong>methylbenzanthracene (DMBA)-<br />
metabolism? Study in a rat model of DMBA-induced mammary carcinogenesis<br />
Racca Silvia 1 , Spaccamiglio A. 1 , Dacasto M. 2 , Carletti M. 2 , Nebbia C. 2 , Abbadessa G. 1 , Di Carlo<br />
F. 1<br />
1 Department of Clinical and Biological Sciences, University of Turin, Orbassano (TO);<br />
2 Department of Animal Pathology, Division of Pharmacology and Toxicology, University of<br />
Turin, Grugliasco (TO)<br />
257. Effect of isothiazolinones on redox omeostasis of rat erythrocytes<br />
* Frosali Simona, * Priora R., * Margaritis A., § Di Stefano A., * Di Giuseppe D., * Summa D., * Di<br />
Simplicio P.<br />
* Department of Neuroscience, Pharmacology Unit, University of Siena. § Department of<br />
Molecular Biology, University of Siena<br />
258. Verminoside and verbascoside from Kigelia Africana: cytotoxic and genotoxic effects<br />
in human lymphocytes<br />
Autore Giuseppina, Santoro A., Bianco G., Picerno P., Aquino R.P., Marzocco S., Gazzerro P.,<br />
Lioi M.B. 1 , Bifulco M.<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, Università <strong>di</strong> Salerno, Fisciano Italy. 1 Dipartimento <strong>di</strong><br />
Scienze delle Produzioni Animali, Università della Basilicata, Potenza Italy<br />
259. DNA fragmentation in peripheral blood lymphocytes of patients with liver cirrhosis<br />
related to alcohol abuse or to hepatitis B or C viruses<br />
Grossi Sarah, Mattioli F., Manfre<strong>di</strong> V., Sumberaz A. * , Testino G. * , Martelli A.<br />
Department of internal Me<strong>di</strong>cine, Pharmacology Unit, University of Genoa, I-16132 Genoa,<br />
Italy. * Gastreoenterology Unit – St. Martino Hospital – Genoa<br />
pag_sx.indd 1 30/05/2007 4.58.11
260. Effects of DP7 on human and rat liver CYP-dependent activities: a kinetic study<br />
D’Elia Paolo, Dragoni S., De Matteis F., Valoti M., Kawase M., Shah A., Motohashi N., Molnar<br />
J., Sgaragli G.<br />
Dipartimento Scienze Biome<strong>di</strong>che, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena, via A. Moro 2, 53100 Siena<br />
261. Formation of DNA-damaging N-nitroso compounds from the interaction of calciumchannel<br />
blockers with nitrite<br />
Robbiano Luigi, Gosmar M., Martelli A.<br />
Department of Internal Me<strong>di</strong>cine, Pharmacology Unit, University of Genoa, I-16132 Genoa,<br />
Italy<br />
262. Low-level lead, cadmium and vana<strong>di</strong>um: "in vitro" evaluation of their genotoxic<br />
potential as influenced by copper, zinc or selenium<br />
Carmignani Marco, Volpe A.R., Cesare P., Aimola P.<br />
Section of Pharmacology and Toxicology, Department of Basic and Applied Biology, University<br />
of L’Aquila, Via Vetoio 2, 67010 Coppito (L’Aquila), Italy<br />
263. Inhibitory enzymatic activity of semicarbazide<br />
Mastrangelo Sabina 1 , Evandri M.G. 2 , Maranghi F. 3 , Mantovani A. 3 , Bolle P. 1<br />
1 Department of Human Physiology and Pharmacology, “Sapienza” University of Rome; 2 Italian<br />
Me<strong>di</strong>cines Agency, Rome; 3 Department of Food Safety and Veterinary Public Health, Italian<br />
National Health Institute, Rome<br />
264. In vitro effects of two over-the-counter bleaching poducts on gingival epithelium<br />
and dental restorative material<br />
Cimino F., Tomaino A., Speciale A., Cristiani M., Trombetta D., Saija A.<br />
1 Dept. Farmaco-Biologico, School of Pharmacy, University of Messina, Italy<br />
109<br />
265. Human umbilical cord-derived hematopoietic stem cells in cyto- and geno-toxicity<br />
stu<strong>di</strong>es: results with cadmium and chromium compounds<br />
Carmignani Marco, Aimola P., Cesare P., Orsini F., Volpe A.R.<br />
Section of Pharmacology and Toxicology, Department of Basic and Applied Biology, University<br />
of L’Aquila, Via Vetoio 2, 67010 Coppito (L’Aquila), Italy<br />
Farmacogenetica, farmacogenomica e terapia genica<br />
Poster 266 – 273<br />
266. Serotonin transporter 5HTTLPR polymorphism, clinical variants and symptom<br />
severity in patients with irritable bowel syndrome<br />
Ghisu Narcisa 1 , Colucci R. 1 , Bellini M. 2 , Rossi G. 3 , Blan<strong>di</strong>zzi C. 1 , Gori G.i 1 , Marchi S. 2 , Tonini<br />
M. 4 , Del Tacca M. 1<br />
1 Division of Pharmacology and Chemotherapy and 2 Gastrointestinal Unit, Department of<br />
Internal Me<strong>di</strong>cine, University of Pisa, Italy; 3 Institute of Clinical Physiology-C.N.R., Italy;<br />
4 Department of Physiological and Pharmacological Sciences, University of Pavia, Italy<br />
267. Adverse effects of azathioprine in pe<strong>di</strong>atric patients with inflammatory bowel<br />
<strong>di</strong>sease and multilocus genotypes of enzymes involved in the metabolism of<br />
thiopurines<br />
Stocco Gabriele 1,2 , Martelossi S. 1 , Barabino A. 3 , Decorti G. 2 , Bartoli F. 1 , Ventura A. 1<br />
1) University of Trieste, Department of Sciences of Reproduction and Development and<br />
I.R.C.C.S. “Burlo Garofolo” Trieste, Pe<strong>di</strong>atric Clinic – 2) University of Trieste, Department of<br />
Biome<strong>di</strong>cal Sciences – 3) I.R.C.C.S. “G. Gaslini”, Genova<br />
pag_dx.indd 1 30/05/2007 4.56.07
268. Corticosensitivity in inflammatory bowel <strong>di</strong>sease: role of glucocorticoid receptor<br />
polymorphisms<br />
De Iu<strong>di</strong>cibus S. 1, 2 , Stocco G. 1, 2 , Drigo I. 1, 2 , Norbedo S. 2 , Bartoli F. 1 , Decorti G. 1, 2 , Martelossi<br />
S. 2 , Ventura A. 2<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Trieste. 2 Department of Pae<strong>di</strong>atrics,<br />
I.R.C.C.S. Burlo Garofolo Trieste<br />
269. Evidence of an increase of the active metabolites of thiopurines induced by<br />
aminosalicylates in inflammatory bowel <strong>di</strong>sease<br />
Marino S. 1, 2 , Stocco G. 1, 2 , Pozzi E. 3 , Martelossi S. 2 , Lionetti P. 3 , Malusà N. 4 , Decorti G. 1, 2<br />
Bartoli F. 1 , Ventura A. 2<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Trieste. 2 Department of Pae<strong>di</strong>atrics,<br />
I.R.C.C.S. Burlo Garofolo Trieste. 3 Research Children’s Hospital ‘Meyer’, Florence.<br />
4 Department of Prevention, Azienda Sanitaria 1, Trieste<br />
270. Influence of thiopurine methyltransferase genotype and phenotype on adverse<br />
events and efficacy of azathioprine in rheumatologic and gastroenterologic patients<br />
Gori Giovanni 1 , Colucci R. 1 , Ghisu N. 1 , Fornai M. 1 , Tani C. 2 , Mosca M. 2 , Ceccarelli L. 3 , Blan<strong>di</strong>zzi<br />
C. 1 , Costa F. 3 , Marchi S. 3 , Bombar<strong>di</strong>eri S. 2 , Del Tacca M. 1<br />
1 Division of Pharmacology and Chemotherapy, 2 Gastroenterology Unit, and 3 Rheumatology<br />
Unit, Department of Internal Me<strong>di</strong>cine, University of Pisa, Pisa, Italy<br />
110<br />
271. Identification of mutations in HERG and KCNE2 genes associated with arrhythmia in<br />
patients treated with macrolides<br />
Pannacci Marilou 1 , Sullo N. 2 , Caronno A. 1 , Lucini V. 1 , Grosso S. 1 , Scaglione F. 1<br />
1 Department of Pharmacology, University of Milan, Milan, Italy. 2 Department of Experimental<br />
Me<strong>di</strong>cine- Section of Pharmacology, 2 nd University of Naples, Naples, Italy<br />
272. An allenic variant of Na+/Ca++ exchanger promoter region, A2689C, plays a role in<br />
<strong>di</strong>astolic blood pressure response to beta-blockers and <strong>di</strong>hydropyri<strong>di</strong>ne Ca ++<br />
antagonists treatment in hypertensive patients<br />
Trimarco Valentina*, Bellis A.**, Marino M.**, Gigante B.**, De Luca N.**, Trimarco B.**,<br />
Annunziato L.*, Di Renzo G.*<br />
*Division of Pharmacology, Dept. of Neuroscience, Federico II University of Naples, Naples,<br />
Italy. **Dept. of Car<strong>di</strong>ovascular and Immunological Sciences, Federico II University of<br />
Naples, Naples, Italy<br />
273. Distribution of CYP3A5 and MDR-1 single nucleotide polymorphisms in Caucasian<br />
liver transplant patients<br />
Provenzani Alessio 1 , Poma P. 2 , Labbozzetta M. 2 , Notarbartolo M. 2 , Di Stefano R. 1 , Triolo F. 3 ,<br />
Vizzini G. 4 , Gridelli B. 5 , D’Alessandro N. 2<br />
1 Department of Clinical Pharmacy - ISMETT, 2 Department of Pharmacological Sciences -<br />
Università <strong>di</strong> Palermo, 3 Regenerative Me<strong>di</strong>cine and Cell Therapy Unit - ISMETT, 4 Department<br />
of Me<strong>di</strong>cine - ISMETT, 5 Department of Abdominal Surgery and Transplantation - ISMETT<br />
Farmaci innovativi <strong>di</strong> origine biotecnologica<br />
Poster 274 – 282<br />
274. Prolonging the action of recombinant human growth hormone by monopegylation of<br />
muteins<br />
Caboi Francesca*, Bossi M.*, Crobu D.*, Cabras A.*, Scaramuzza S.*, Taylor G.*<br />
*Bio-Ker s.r.l. c/o Scientific and technologic Park of Sar<strong>di</strong>nia Polaris, Loc. Piscinamanna Pula<br />
(Cagliari)<br />
pag_sx.indd 1 30/05/2007 4.57.32
275. Novel G-CSF mutant for conjugation<br />
Salis Barbara, Caboi F., Pitzalis S., Maullu C., Sergi M., Sollai L., Taylor G.<br />
Bio-Ker s.r.l. c/o Scientific and technologic Park of Sar<strong>di</strong>nia Polaris, Loc. Piscinamanna Pula<br />
(Ca)<br />
276. New long lasting PEGylated-hGH<br />
Selis Fabio*, Scaramazza S.*, Contis M.*, Pasut G. + , Veronese F. + , Schrepfer R.*<br />
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Padova,<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche<br />
277. Silica Microparticles for the controlled release of human growth hormone<br />
Sergi Mauro*, Morpurgo M. + , Selis F.*, Parisi L. + , Concas D.*, Marongiu C.*, Schrepfer R.*,<br />
Tonon G.*<br />
* Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA)<br />
+ Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Padova, Dipartimento <strong>di</strong> Scienze Farmaceutiche<br />
278. Inhibition of NF-kB activation by decoy ODN released from liposomes in activated<br />
macrophages<br />
De Stefano Daniela 1 , Maiuri M.C 1 ., Simeon V. 1 , De Rosa G. 2 , LaGuar<strong>di</strong>a V. 2 , Carnuccio R. 1<br />
1 Department of Experimental Pharmacology; 2 Department of Pharmaceutical Sciences;<br />
University of Naples “Federico II”, Via D. Montesano n 49, 80131 Naples, Italy<br />
279. Osteogenic <strong>di</strong>fferentiation of human a<strong>di</strong>pose-derived stem cells (hASC)<br />
De Girolamo L. 1;2 , Sartori M. 1 , Bastoni S. 3 , Brini A.T. 1<br />
1 Me<strong>di</strong>cal Pharmacology Department, Faculty of Me<strong>di</strong>cine, University of Milan.<br />
2 IRCCS Galeazzi Orthope<strong>di</strong>c Institute, Milan. 3 Orthope<strong>di</strong>c and Traumatological Institute,<br />
Faculty of Me<strong>di</strong>cine, University of Milan<br />
111<br />
280. In vitro effects of anti-inflammatory drugs incorporated in solid lipid nanoparticles<br />
on human peripheral mononuclear blood cells from IBD patients<br />
Serpe Loredana 1 , Canaparo R. 2 , Daperno M. 3 , Ean<strong>di</strong> M. 1 , Gasco M.R. 4 , Zara G.P. 1<br />
1 Department of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine, University of <strong>Torino</strong>, <strong>Torino</strong>,<br />
2 Department of Clinical Pathophysiology, University of <strong>Torino</strong>, <strong>Torino</strong>, 3 Department of<br />
Gastroenterology, Mauriziano Hospital, <strong>Torino</strong>, 4 Nanovector s.r.l, <strong>Torino</strong><br />
281. PEGylation of Recombinant Human Granulocyte Colony-Stimulating Factor (r-h-G-<br />
CSF) produced in Escherichia coli: a new drug to overcome neutropenia<br />
Bonatesta Rosa Rita*, Caboi F.*, Sergi M.*, Sollai L.*, Onali P. + , Schrepfer R.* Tonon G.*<br />
*Bioker S.r.l. c\o Polaris-Loc Piscinamanna, Pula (CA). + Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Cagliari,<br />
Dipartimento <strong>di</strong> Neuroscienze<br />
282. EMEA and emerging therapies and technologies: activity of the Innovation Task<br />
Force<br />
De Lisa Roberto, Ranzani D., Brassart L., Moulon I., Papaluca Amati M.<br />
EMEA European Me<strong>di</strong>cines’ Agency<br />
Appropriatezza della prescrizione dei farmaci<br />
Poster 283<br />
283. In<strong>di</strong>pendent drug information and prescibing appropriateness: a chance for health<br />
professionals and patients<br />
Luppino Maria R. 1,3 , Alacqua M. 1,3 , Catania M.A. 1,3 , Fava G. 1,3 , Gentile M. 1,3 , Oteri A. 1,3 ,<br />
Polimeni G. 1,2,3 , Russo A. 1,3 , Aliferopulos H. 3 , Genovese R. 3 , Sgroi C. 3 , Silvestro A. 3 , Zangla<br />
A. 3 , Caputi A. P. 1,2,3<br />
1 University of Messina -<br />
2 IRCSS “Bonino-Pulejo”, Messina -<br />
3 Messina Provincial Drug<br />
Information Center<br />
pag_dx.indd 1 30/05/2007 4.59.24
Sessione Poster<br />
Recettori e meccanismi <strong>di</strong> trasduzione del segnale<br />
Poster 1-20<br />
13.00-15.00<br />
1. Pharmacological characterization of adenosine receptors in bovine chondrocytes<br />
Tosi A. 1 , Varani K. 1 , Vincenzi F. 1 , Gessi S. 1 , Merighi S. 1 , Fogli E. 1 , Sacchetto V. 1 , Simioni C. 1 ,<br />
De Mattei M. 2 , Caruso A. 2 , Borea P.A. 1<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Section; 2 Department of<br />
Morphology and Hystology, University of Ferrara, Italy<br />
2. Bin<strong>di</strong>ng thermodynamics at the human A 2B adenosine receptor<br />
Fogli Eleonora 1 , Gessi S. 1 , Varani K. 1 , Merighi S. 1 , Sacchetto V. 1 , Simioni C. 1 , Leung E. 2 ,<br />
Mac Lennan S. 2 , Borea P.A. 1<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Unit and Inter<strong>di</strong>sciplinary<br />
Center for the Study of Inflammation, University of Ferrara, Italy; 2 King Pharm. Research and<br />
Development, Inc., Cary, North Carolina.<br />
112<br />
3. Adenosine modulates vascular endothelial growth factor expression via hypoxiainducible<br />
factor-1 in human glioblastoma cells<br />
Sacchetto Valeria 1 , Merighi S. 1 , Benini A. 1 , Mirandola P. 2 , Gessi S. 1 , Varani K. 1 , Simioni C.1,<br />
Fogli E.1, Leung E. 3 , Mac Lennan S. 3 , Borea P.A. 1 .<br />
1 Dpt of Clin. and Exp. Med., Pharmacol. Unit and Inter<strong>di</strong>sciplinary Center for the Study of<br />
Inflammation, Univ. of Ferrara, Italy; 2 Dpt of Human Anat., Pharmacol. and For. Med., Univ.<br />
of Parma, Italy; 3 King Pharm. Research and Development, Inc., Cary, North Carolina.<br />
4. Activated presynaptic P2x 7 receptors function as calcium channels linked to<br />
exocytotic glutamate release<br />
Guarnieri Stefania 1 , Paluzzi P. 1 , Cervetto C. 1 , Alloisio S. 2 , Nobile M. 2 , Marcoli M.1, Maura G. 1 *<br />
1 Dep. Experimental Me<strong>di</strong>cine, Pharmcology and Toxicology Section; * Center of Exellence for<br />
Biome<strong>di</strong>cal Research, University of Genoa, Genoa, Italy; 2 CNR, Biophysic Intitute, Genoa, Italy<br />
5. Activated P2x 7 receptors allow calcium entry and glutamate exit: investigation on<br />
transfected HEK 293 cells<br />
Paluzzi Paola 1 , Cervetto C. 1 , Guarnieri S. 1 , Alloisio S. 2 , Nobile M. 2 , Marcoli M. 1 , Maura G. 1*<br />
1 Dep. Experimental Me<strong>di</strong>cine, Pharmcology and Toxicology Section; * Center of Exellence for<br />
Biome<strong>di</strong>cal Research, University of Genoa, Genoa, Italy; 2 CNR, Biophysic Intitute, Genoa,<br />
Italy<br />
6. Extracellular Mg 2+ modulates C-terminal tail dependent P2x 7 receptor functional<br />
properties<br />
Alloisio Susanna, Barbieri R., Bozzo L., Nobile M.<br />
Institute of Biophysics, CNR, Via De Marini, 6 – 16149 Genoa, Italy<br />
7. Arachidonic acid potentiates native and recombinant P2x 7 -me<strong>di</strong>ated ERK1/2, but<br />
not JNK and p38 phosphorylation in cultured cortical astrocytes and human<br />
embryonic kidney 293 cells<br />
Barbieri Raffaella 1 , Alloisio S. 1 , Ferroni S. 2 , Nobile M. 1<br />
1 Institute of Biophysics, CNR, 16149 Genoa, Italy; 2 Dept. of Human and General Physiology,<br />
University of Bologna, 40127 Bologna, Italy<br />
pag_sx.indd 1 30/05/2007 5.04.34
8. Purinergic facilitation of parasympathetic activity in isolated pig detrusor:<br />
involvement of prejunctional P2X 3 receptors<br />
D’Agostino G., Con<strong>di</strong>no A.M., Barbieri A., Tonini M*<br />
Department of Experimental and Applied Pharmacology, School of Pharmacy, University of<br />
Pavia, Via Taramelli 14, and * Department of Physiological and Pharmacological Sciences, P.za<br />
Botta 10, I-27100 Pavia, Italy<br />
9. Role of P2 purinergic receptors on ca1 neurotransmission of rat hippocampal slices<br />
Traini Chiara , Coppi E., Pugliese A. M., Pedata F.<br />
Department of Preclinical and Clinical Pharmacology, University of Florence,<br />
Viale Pieraccini 6, 50139 Florence, Italy<br />
10. Role of PKA in EGFR transactivation induced by PGE2 in A431 cells<br />
Terzuoli Erika, Finetti F., Ziche M.<br />
Laboratory of angiogenesis, Department of Molecular Biology, University of Sien<br />
11. Insulin-like growth factor i (IGF-I) induces human mu opioid receptor (MOR)<br />
expression in <strong>di</strong>fferentiated neurons: role of transcription factors rest and STAT3<br />
Be<strong>di</strong>ni Andrea, Di Toro R. , Spampinato S.<br />
Department of Pharmacology and Toxicology – University of Bologna Irnerio 48 – 40126<br />
Bologna – Italy<br />
12. Resistin induces vascular insulin resistance through an impairment of AKT/eNOS<br />
phosphorylations<br />
Di Pardo Alba°, Gentile M.T.°, Vecchione C.°, Marino G.°, Antenucci G.°, Maffei A.°,<br />
Lembo G.° #<br />
°Department of Angio-Car<strong>di</strong>o-Neurology, Neuromed Institute, Pozzilli (IS), and # Department<br />
of Experimental Me<strong>di</strong>cine, “La Sapienza” University of Rome<br />
113<br />
13. Interaction between Wnt pathway and orphan nuclear receptors<br />
Motolese Marta 1 , Orlando R. 1 , Caricasole A. 3 , Terstappen G. C. 3 , Melchiorri D. 1 , Nicoletti F.<br />
1,2 , Caruso A. 1<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”;<br />
2 I.N.M. Neuromed , Pozzilli; Italy; 3 Sienabiotech s.p.a. Siena<br />
14. Study of synthetic peptides derived from PKI55, a PKC modulator, in stimulated<br />
human neutrophils<br />
Falzarano Sofia 1 , Franceschetti L. 1 , Spisani S. 2 , Selvatici R. 1<br />
1 Department of Experimental and Diagnostic Me<strong>di</strong>cine, Section of Me<strong>di</strong>cal Genetics, University<br />
of Ferrara; 2 Department of Molecolar Biochemistry and Biology, University of Ferrara<br />
15. The thyroid <strong>di</strong>sruptor 1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane appears to be<br />
an uncompetitive inverse agonist for the thyrotropin receptor<br />
Rossi Mario, Donati E., Dimida A., Ferrarini E., Agretti P., Giorgi F., Corsini G.U., Pinchera<br />
A., Vitti P., Tonacchera M., Maggio R.<br />
Department of Neuroscience (M.R., E.D., F.G., G.U.C.) and Department of Endocrinology,<br />
Centre of Excellence for the Study of Damage to the Nervous and Endocrine Systems<br />
Produced by Environmental, Alimentary, and Pharmacological Agents, AmbiSEN (A.D., E.F.,<br />
P.A., A.P., P.V., M.T.), University of Pisa, Pisa, Department of Experimental Me<strong>di</strong>cine,<br />
University of L’Aquila, Italy<br />
pag_dx.indd 1 30/05/2007 5.05.19
16. Pharmacological characterisation of the urotensin-ii receptor ligands urantide and<br />
UFP-803 in CHO hUT cells<br />
Batuwangala Madura 1,3 , Camarda V. 1 , Marzola E. 2 , McDonald J. 3 , Lambert D. G. 3 , Ng L. 3 ,<br />
Guerrini R. 2 , Regoli D. 1 , Calo’ G. 1<br />
1 Dept. of Pharmacology and 2 Dept. of Pharmaceutical Sciences, University of Ferrara, 44100<br />
Ferrara, Italy. 3 Dept. of Car<strong>di</strong>ovascular Sciences, Division of Anaesthesia, Pharmacology and<br />
Therapeutics, University of Leicester, Leicester, LE2 7LX, UK<br />
17. Stimulation of ephrin B induces mo<strong>di</strong>fications of hippocampal synaptic plasticity in<br />
neonatal and adult rats<br />
Piccinin Sonia 1 , Cinque C. 1 , Calo’ L. 1 , Patanè M. 1 , Melchiorri D. 1 , Bashir Z. 3 , Eusebi F. 1,2. ,<br />
Nicoletti F. 1,2<br />
1 Department of Human Physiology and Pharmacology, University La Sapienza of Rome, Italy;<br />
2 I.N.M. Neuromed, Pozzilli, Italy; 3 MRC Centre for synaptic plasticity, Department of Anatomy,<br />
University of Bristol, UK<br />
18. PGE2 promotes egfr transactivation and squamous cell carcinoma growth by the<br />
NOS and ERK1/2 pathways<br />
Solito Raffaella, Ziche M., Morbidelli L.<br />
Section of Pharmacology, Department of Molecular Biology, University of Siena<br />
114<br />
19. Selective H3 receptor isoforms activate Akt/GSK axis and ERK in rat cortical<br />
neurons<br />
Mariottini Chiara 1 , Bongers G. 3 , Leurs R. 3 , Fossati S. 2 , Chiarugi A. 2 , Blan<strong>di</strong>na P. 2 , Passani<br />
M.B. 2<br />
1 Dipartimento <strong>di</strong> Fisiologia, V.le Morgagni 65, Firenze, Italy; 2 Dipartimento <strong>di</strong> Farmacologia<br />
Preclinica e Clinica, V.le Pieraccini 6, Firenze, Italy; 3 Department of Me<strong>di</strong>cinal Chemistry, Vrije<br />
Universiteit, Amsterdam, The Netherlands<br />
20. Nitric oxide/cGMP signaling pathway exerts tonic control on intraocular pressure<br />
(IOP) homeostasis in rabbits<br />
Bastia Elena, Guzzetta M., Bion<strong>di</strong> S., Impagnatiello F.<br />
Nicox Research Institute, Bresso, Milano, Italy<br />
I canali ionici ed i meccanismi <strong>di</strong> trasporto<br />
Poster 21 – 30<br />
21. The effects of acetazolamide on calcium activated k+ channels in skeletal muscle<br />
are me<strong>di</strong>ated by interaction with the alpha subunit<br />
Mele Antonietta 1 , Tricarico D. 1 , Latorre R. 2 , Torres Y. 2 , Conte Camerino D. 1<br />
1 Dept. of Pharmacobiology, Fac of Pharmacy,University of Bari, Bari Italy; 2 Centro de Estu<strong>di</strong>os<br />
Cientificos, Val<strong>di</strong>via, Chile<br />
22. Fluvastatin may induce a chronic reduction of the store operated calcium entry in<br />
striated fibres: an other brick in the wall of the hypolipedemic drugs' myotoxicity?<br />
Rolland Jean-Francois, Liantonio A., Conte Camerino D.<br />
Department Pharmaco-Biology, Faculty of Pharmacy, University of Bar<br />
23. Hydrophobicity of phenylalanine 1586 within the pore of the human Nav1.4 so<strong>di</strong>um<br />
channel is a determinant of local anesthetic bin<strong>di</strong>ng<br />
Desaphy Jean-François 1 , Dipalma A. 1 , Catalano A. 2 , Lentini G. 2 , Franchini C. 2 , Tortorella<br />
V. 2 , Conte Camerino D. 1<br />
1 Section of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University<br />
of Bari, Via Orabona 4 – campus, 70125 Bari, Italy; 2 Department of Me<strong>di</strong>cinal Chemistry,<br />
Faculty of Pharmacy, University of Bari<br />
pag_sx.indd 1 30/05/2007 5.06.32
24. Structural requirements of n-benzyl tocainide analogs for stereoselective and potent<br />
block of skeletal muscle so<strong>di</strong>um channels<br />
1 De Bellis Michela, 1 De Luca A., 2 Corbo F., 2 Muraglia M., 2 Franchini C., 2 Tortorella P., 1 Conte<br />
Camerino D.<br />
1 Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of<br />
Bari and 2 Department of Me<strong>di</strong>cal Chemistry, Faculty of Pharmacy University of Bari, Italy<br />
25. Cellular and subcellular localization of Na + -Ca 2+ exchanger (NCX) 1, 2 and 3 in<br />
central nervous system (CNS)<br />
Magi Simona 1 , Castaldo P. 1 , Salucci S. 3 , Gobbi P. 3 , Minelli A. 2 , Amoroso S. 1<br />
1 Section of Pharmacology, Department of Neuroscience, University “Politecnica delle Marche”,<br />
Ancona and Institute of 2 Physiological and 3 Morphological Sciences, University of Urbino “Carlo<br />
Bo”<br />
26. Transport of pyri<strong>di</strong>ne nucleotides across the plasma membrane in mammalian cells<br />
Ercolano Emanuela, Billington R. A, Condorelli F., Canonico P.L., Genazzani A.A.<br />
DiSCAFF, Università del Piemonte Orientale, Novara<br />
27. So<strong>di</strong>um calcium exchanger and so<strong>di</strong>um dependent glutamate transporters<br />
involvement in energy production, in rat heart<br />
1 Castaldo Pasqualina, 2 Rodolico G., 2 Piegari E., 1 Magi S., 1 Corcione E., 2 Berrino L., 1 Amoroso<br />
S.<br />
1 Section of Pharmacology, Department of Neuroscience, Università “Politecnica delle Marche”,<br />
Ancona; 2 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology, Second University<br />
of Naples<br />
28. Taurine prevents the <strong>di</strong>suse-associated alteration of soleus muscle calcium<br />
homeostasis in the hindlimb-unloaded rats<br />
Giannuzzi Viviana, Liantonio A., Desaphy Jean-François, Pierno S., Conte Camerino D.<br />
Section of Pharmacology, Dept. of Pharmacobiology, University of Bari, Italy<br />
115<br />
29. Evaluation of the effects of a combined chronic treatment with atorvastatin and<br />
fenofibrate on rat skeletal muscle: an ex vivo electrophysiological and<br />
cytofluorimetric study<br />
Cippone Valentina, Giannuzzi V., Pierno S., Liantonio A., Conte Camerino D.<br />
Dept. of Pharmacobiology, Section of Pharmacology, Faculty of Pharmacy, University of Bari,<br />
Italy<br />
30. Pharmacological targeting of renal clc-k chloride channels: ligands structural<br />
requirements and therapeutic potential<br />
Liantonio Antonella 1 , Picollo A. 2 , Babini E. 2 , De Bellis M. 1 , Fracchiolla G. 3 , Carbonara G. 3 ,<br />
Tortorella P. 3 , Pusch M.l 2 , Conte Camerino D. 1<br />
1 Section of Pharmacology, Dept. of Pharmacobiology, University of Bari, Italy; 2 Institute of<br />
Biophysic-CNR, Genova, Italy; 3 Dept. of Me<strong>di</strong>cinal Chemistry, University of Bari, Italy<br />
Controllo farmacologico dei processi <strong>di</strong> morte e proliferazione cellulare<br />
Poster 31 – 45<br />
31. Endocannabinoids contribute to the neuroprotective effects of mGlu1 receptor<br />
antagonists against post-ischemic neuronal death<br />
Landucci Elisa, Scartabelli T., Cozzi A., Mannaioni G., Moroni F., Pellegrini G.D.<br />
Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze, Viale Pieraccini 6,<br />
50139 Firenze<br />
pag_dx.indd 1 30/05/2007 5.07.23
32. Transforming growth factor-1 protects rat cortical neurons against early and late -<br />
amyloid toxicity<br />
Caraci Filippo 1 , Copani A. 1 , Battaglia G. 2 , Nicoletti F. 2,3 , Sortino M.A. 4<br />
1 Dept. of Pharmaceutical Sciences, University of Catania ; 2 I.N.M. Neuromed, Pozzilli, Italy,<br />
3 Dept. of Human Physiology and Pharmacology, University of Rome ‘‘La Sapienza’’; 4 Dept. of<br />
Experimental and Clinical Pharmacology, University of Catania<br />
33. -Amyloid effects in <strong>di</strong>fferentiation and death of neural progenitor cell-derived<br />
neurons<br />
Calafiore Marco 1 , Giuffrida M.L. 1 , Sortino M.A. 2 , Copani A 1<br />
1 Department of Pharmaceutical Sciences,<br />
2 Department of Experimental and Clinical<br />
Pharmacology, University of Catania, Catania.<br />
34. Differential role of mGlu1 and mGlu5 receptors in rat hippocampal slice models of<br />
ischemic tolerance<br />
Scartabelli Tania, Landucci E., Moroni F., Pellegrini G.D.<br />
Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze, Viale Pieraccini 6,<br />
50139 Firenze.<br />
116<br />
35. Regulation of autophagy by the inositol trisphosphate receptor<br />
Maiuri Maria Chiara 1,2 , Criollo A. 2 , Tasdemir E. 2 , Carnuccio R. 1 , Kroemer G. 2<br />
1 Department of Experimental Pharmacology, Faculty of Biotechnological Sciences, University<br />
of Naples “Federico II”, Via D. Montesano 49, 80135 Napoli, Italy; 2 INSERM U848, University<br />
“Paris Sud”, Institut G. Roussy, 39 rue C. Desmoulins, F-94805 Villejuif, France<br />
36. Peripheral neuropathies: apoptosis-preventing activity of Acetyl-L-Carnitine<br />
Di Cesare Mannelli Lorenzo*, Ghelar<strong>di</strong>ni C.*, Vivoli E.*, Toscano A. § , Bartolini A.*<br />
* University of Florence, Dept. of Preclinical and Clinical Pharmacology, Viale Pieraccini 6,<br />
50139, Florence, Italy; § University of Florence, Dept. of Anatomy Hystology and Forensic<br />
Me<strong>di</strong>cine, Viale Morgagni 85, 50139, Florence, Italy<br />
37. Effects of combination treatment with azidothymi<strong>di</strong>ne and pharmacological<br />
inhibitors of NF-kB on apoptotic cell death in uninfected or virus-infected<br />
transformed cell lines<br />
3,5 Macchi Beatrice, 1 Minutolo A. 2 Matteucci C. , 1 , Balestrieri E. 3 Ascolani A. 4 Mastino A.<br />
1 Department of Experimental Me<strong>di</strong>cine and Biochemical Science, University of Rome “Tor<br />
Vergata”, Rome;<br />
2 Institute of Neurobiology and Molecular Me<strong>di</strong>cine, C.N.R., Rome;<br />
3 Department of Neuroscience, University of Rome “Tor Vergata”, Rome; 4 Department of<br />
Microbiological, Genetic and Molecular Sciences, University of Messina, Messina. 5 IRCCS Santa<br />
Lucia Rome, Italy<br />
38. Modulation of Bcl-2 expression by gemcitabine and nimesulide in human pancreatic<br />
tumor cell lines<br />
Longoni Biancamaria, Giovannetti A,, Bertacca L, Navarra T. , Mosca F.<br />
Department of Oncology, Transplantation and Advanced Technologies in Me<strong>di</strong>cine, University<br />
of Pisa<br />
39. Protective effect of levetiracetam versus oxygen stress -induced cell death in PC12<br />
and in SH-SY5Y cell lines<br />
1 Ascolani Arianna, 2 Matteucci C., 2 Balestrieri E, 3 Caltagirone C., 1,3 Macchi B.<br />
1 Department of Neuroscience, University of Rome “Tor Vergata”, Rome, Italy. 2 Department of<br />
Experimental Me<strong>di</strong>cine and Biochemical Science, University of Rome “Tor Vergata”, Rome,<br />
Italy. 3 IRCCS S. Lucia Rome, Italy<br />
pag_sx.indd 1 30/05/2007 5.08.31
40. Role of reactive oxygen species (ROS) in the antiapoptotic effect of oxysterols on<br />
human umbilical vein endothelial cells (HUVEC)<br />
Poggiani Chiara, Agnoletto L., Cusinato F., Trevisi L., Luciani S.<br />
Department of Pharmacology and Anaestesiology, University of Padova<br />
41. Hydrogen peroxide-dependent ERK1/2 dephosphorylation me<strong>di</strong>ates toxicity via<br />
upstream inhibition of the survival signalling in U937 cells exposed to peroxynitrite<br />
Cerioni Liana, Cantoni O.<br />
Institute of Pharmacology and Pharmacognosy, University of Urbino “Carlo Bo”<br />
42. Subnormothermic machine perfusion reduces necrosis and apoptosis and improves<br />
energy status during preservation of steatotic rat livers: implications for<br />
transplantation<br />
1 Ferrigno Andrea, 2 Rizzo V., 3 Carlucci F., 3 Tabucchi A., 4 Boncompagni E., 1 Richelmi P., 5 Cillo U,<br />
4 Freitas I., 1 Vairetti M.<br />
1 Dept. Int. Med. and Therapeutics and 2 Dept. of Biochemistry, IRCCS San Matteo, Univ. of<br />
Pavia; 3 Dept. Int. Med., Univ. of Siena, 4 Dept. of Animal Biology and IGM-CNR, Univ. of Pavia,<br />
5 Dept. General Surgery, Univ. of Padua<br />
43. A pathogenetic hypothesis of Unverricht-Lundborg <strong>di</strong>sease onset and progression<br />
Buzzi Andrea b , Franceschetti S. a , Sancini G. a , Zucchini S. b , Para<strong>di</strong>so B. b , Magnaghi G. a ,<br />
Frassoni C. a , Chikhladze M. a , Avanzini G. a , Simonato M. b<br />
a Neurological Institute “C. Besta”, Milan, Italy; b University of Ferrara, Italy<br />
44. Antiapoptotic effects of green tea polyphenol epigallocatechin-3-gallate (EGCG) on<br />
ischemic injury of the rat retina<br />
Tamburella Alessandra, Leggio G.M., Drago F.<br />
Department of Experimental and Clinical Pharmacology, University of Catania, Catania, Italy<br />
117<br />
45. Melanocortins improve wound healing in experimental burn injury<br />
Bazzani Carla 1 , Giuliani D. 1 , Mioni C. 1 , Galantucci M. 1 , Zaffe D. 2 , Minutoli L. 3 , Bitto A. 3 ,<br />
Botticelli A. R. 4 , Altavilla D. 3 , Squadrito F. 3 , Guarini S. 1<br />
1 Dept. Biome<strong>di</strong>cal Sciences, Sect. Pharmacology, and 2 Dept. Anatomy and Histology,<br />
University of Modena and Reggio Emilia; 3 Dept. Clinical Exp. Me<strong>di</strong>cine and Pharmacology,<br />
Sect. Pharmacology, University of Messina; 4 Dept. Human Pathology, University of Pavia<br />
Farmacologia della trasmissione sinaptica<br />
Poster 46 – 53<br />
46. Muscarinic control of parasympathetic activity in isolated porcine airways:<br />
involvement of M1/M2 muscarinic autoreceptors<br />
Con<strong>di</strong>no A.M., Barbieri A., Zonta F., D’Agostino G.<br />
Department of Experimental and Applied Pharmacology, School of Pharmacy, University of<br />
Pavia, Via Taramelli 14, I-27100 Pavia, Italy<br />
47. Hierarchical control of dopamine neuron-firing patterns by neuronal nicotinic<br />
receptors<br />
Mameli-Engvall Monica 1,2,3 , Evrard A. 2 , Pons S. 2 , Maskos U. 2 , Svensson H.T. 1 , Changeux J-P. 2 ,<br />
Faure P. 2<br />
1 Karolinska Institute, Dept. Physiology and Pharmacology, S-17177 Stockholm, Sweden;<br />
2 Institut Pasteur, Unité Récepteurs et Cognition, URA CNRS 2182, Paris Cedex 15, France ;<br />
3 EDX Diagnostics SPA, Sardegna Ricerche, Localita’ Piscinamanna, Ed.3, 09010 Pula, Italy<br />
pag_dx.indd 1 30/05/2007 5.09.24
48. The release of endocannabinoids in the CA1 hippocampal area is modulated by<br />
mGlu1 receptors: a patch clamp study<br />
Mannaioni Guido, Baccini G., Landucci E., Moroni F., Pellegrini G.D.<br />
Dipartimento <strong>di</strong> Farmacologia Preclinica e Clinica, Università <strong>di</strong> Firenze, Viale Pieraccini 6,<br />
50139 Firenze<br />
49. Evidence for a possible interaction between cannabinoid and serotonergic systems<br />
in modulating inhibitory synaptic transmission in basolateral amygdala<br />
Domenici M.R. 1 , Marsicano G. 2 , Azad S.C. 3 , Lutz B. 4 , Popoli P. 1 , Zieglgänsberger W. 3 , Rammes<br />
G. 3<br />
1 Dep. Drug Res and Evaluation, Istituto Superiore <strong>di</strong> Sanità, Rome, Italy ; 2 Centre de<br />
Recherche INSERM François Magen<strong>di</strong>e, Bordeaux, France; 3 Max-Planck Institut for Psychiatry,<br />
Munich, Germany; 4 Dep of Physiological Chemistry,Johannes Gutenberg University, Mainz,<br />
Germany<br />
50. Pharmacological characterization of a new non-imidazole histamine H 3 antagonist<br />
Flammini Lisa, Bertoni S., Saccani F., Ballabeni V., Impicciatore M., Barocelli E.<br />
Department of Applied Pharmacological, Biological and Chemical Sciences, University of<br />
Parma, V.le GP Usberti 27/a, Parma<br />
118<br />
51. Serotonin efflux from rat dorsal raphe nucleus slices: modulation by corticotropin<br />
releasing factor<br />
Marino Silvia, Nazzaro C., Siniscalchi A.<br />
Department of Clinical and Experimental Me<strong>di</strong>cine University of Ferrara Via Fossato <strong>di</strong><br />
Mortara, 17-19 44100 Ferrara<br />
52. Monoaminergic changes in locus coeruleus and dorsal raphe nucleus following<br />
noradrenaline depletion<br />
Macheda Teresa 1 , Cassano T. 1 , Morgese M.G. 1 , Trabace L. 1 , Cuomo V. 2 , Gobbi G. 3<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Foggia, Italy;<br />
2 Department of<br />
Pharmacology and General Physiology, University of Rome, ‘La Sapienza’, Italy; 3 Dept. of<br />
Psychiatry, McGill University, Montréal, Qc, Canada<br />
53. Functional proteomics of neuroplasticity-related signaling in a rat model of<br />
depression with gene-enviroment interaction<br />
Musazzi Laura 1 , Giambelli R. 1,2 , Tar<strong>di</strong>to D. 1 , Caffino L. 1 , El Khoury A. 3 , Mathé A. 3 , Racagni<br />
G. 1 , Popoli M. 1<br />
1 Center of Neuropharmacology-Department of Pharmacological Sciences, University of Milano,<br />
Italy; 2 Department of Experimental and Clinical Pharmacology, School of Me<strong>di</strong>cine, University<br />
of Catania, Catania (Italy); 3 Karolinska Institutet, Inst. of Clinical Neuroscience, Karolinska<br />
Hospital Hud<strong>di</strong>nge, Stockholm (Sweden)<br />
Farmacologia car<strong>di</strong>ovascolare<br />
Poster 54 – 72<br />
54. Endothelial cells response to polyethylene terephthalate surfaces activated by<br />
irra<strong>di</strong>ation<br />
Pezzatini Silvia 1 , Satriano C. 2 , Morbidelli L. 1 , Ziche M. 1<br />
1 Pharmacology section, Dept Molecular Biology, University of Siena, Via A. Moro 2, 53100<br />
Siena, Italy; 2 Laboratory for Molecular Surfaces and Nanotechnologies and CSGI, Dept. of<br />
Chemical Sciences, University of Catania, viale A. Doria 6, 95025 Catania, Italy<br />
55. Peroxynitrite inactivates human-tissue inhibitor of metalloproteinase-4 (TIMP-4)<br />
favouring coronary endothelial cell motility<br />
Monti Martina, Donnini S., Morbidelli L., Ziche M.<br />
Laboratory of Angiogenesis, Department of Molecular Biology, University of Siena<br />
pag_sx.indd 1 30/05/2007 5.10.44
56. Ace inhibitor-induced angiogenesis in coronary endothelium is me<strong>di</strong>ated by<br />
Fibroblast growth factor-2<br />
Donnini Sandra, Giachetti A., Ziche M., Morbidelli L.<br />
Laboratory of Angiogenesis, Dept. Molecular Biology, University of Siena, Siena, Ital<br />
57. Membrane proteins involved in flavonoid transport in endothelial cells<br />
Maestro Alessandra , Terdoslavich M. , Petris G. , Passamonti S. , Decorti G. <br />
Department of Biome<strong>di</strong>cal Sciences and Department of Biochemistry, Biophysics and<br />
Chemistry of Macromolecules, University of Trieste, Trieste<br />
58. A nitric oxide releasing pravastatin derivative, NCX 6550, improves vascular<br />
response in human and hypertensive rat vessels<br />
Presotto C., Miglietta D., Olivieri R., Uzzo M., Vago T.*, Gelpi G. # , Monopoli A.<br />
Nicox Research Institute, Bresso, Milan, Italy; * Department of Endocrinology, University<br />
Hospital “L.Sacco”, Milan; # Division of Car<strong>di</strong>ovascular Surgery, “L.Sacco” Hospital, Milan<br />
59. Nebivolol induces nitric oxide productione in the heart<br />
Maffei A. 1 , Poulet R. 1 , Di Pardo A. 1 , Carangi R. 1 , Carullo P. 1 , Gentile M.T. 1 , Lembo G. 1,2<br />
1 IRCCS Neuromed, Pozzili (IS); 2 La Sapienza University, Rome<br />
60. Role of protein kinase C and Rho kinase in the rat-selective vasoconstrictor effect of<br />
normormide<br />
1 Cavalli Maurizio, 2 Papparella I., 2 Ceolotto G., 1 Bova S.<br />
1 Department of Pharmacology and Anesthesiology, University of Padova; 2 Department of<br />
Clinical and Experimental Me<strong>di</strong>cine, University of Padova<br />
61. Hydrogen sulphide involvement in vascular tone in <strong>di</strong>abetic rats<br />
D’Emmanuele <strong>di</strong> Villa Bianca Roberta, Sorrentino R., Miti<strong>di</strong>eri E., Sorrentino R.<br />
Department of Experimental Pharmacology, University of Naples Federico II<br />
119<br />
62. Hyperglycemia-me<strong>di</strong>ated overexpression of cyclooxygenase-2 (COX-2) participates<br />
in vascular hyporeactivity of streptozotocin-induced type I <strong>di</strong>abetes<br />
Tarquinio Mariela, Nacci C., De Bene<strong>di</strong>ctis L., Montagnani M.<br />
Department of Pharmacology and Human Physiology - Me<strong>di</strong>cal School - University of Bari,<br />
70124 Bari, ITALY<br />
63. Neutrophil-dependent cerebral oedema in normal and <strong>di</strong>abetic rat: role of<br />
transcellular synthesis of cysteinil leukotrienes<br />
Brivio Ivan, Buccellati C., Di Gennaro A., Folco G., Sala A.<br />
Center for Car<strong>di</strong>opulmonary Pharmacology, Dep. of Pharmacological Sciences, University of<br />
Milan<br />
64. Angiotensin ii involvement in remodelling of carotids subjected to pressure overload<br />
Bianco Giuseppe 1 , Miti<strong>di</strong>eri E. 2 , D’Emmanuele <strong>di</strong> Villa Bianca R. 2 , Pinto A. 1 , Autore G. 1 ,<br />
Sorrentino R. 2<br />
1 Dipartimento <strong>di</strong> Scienze Farmaceutiche, Università <strong>di</strong> Salerno, Salerno; 2 Dipartimento <strong>di</strong><br />
Farmacologia Sperimentale, Università <strong>di</strong> Napoli, Federico II<br />
65. Evaluation of the effect of two <strong>di</strong>fferent doses of aspirin in patients undergoing<br />
coronary artery bypass graft (CABG)<br />
Brambilla Marta 1 , Centenaro C. 2 , Tremoli E. 1,2 , Parolari A. 2 , Camera M. 1,2<br />
1 Dept. Pharmacological Sciences, University of Milan; 2 Centro Car<strong>di</strong>ologico Monzino IRCCS,<br />
Milan, Italy<br />
pag_dx.indd 1 30/05/2007 5.11.54
66. Polydeoxyribonucleotide (PDRN) increases vegf production and blood flow in an<br />
experimental model of hind limb ischemia in rats<br />
Fiumara Tiziana 1 , Polito F. 1 , Bitto A. 1 , Minutoli L. 1 , Di Stefano V. 1 , Altavilla D. 1 , Cattarini G. 2 ,<br />
Caputi A.P 1 , Squadrito F. 1<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina<br />
and 2 Mastelli srl, Sanremo, Italy<br />
67. Hydrogen sulfide (H 2 S) inhibits aggregation of human platelets<br />
Zagli Giovanni 1 , Patacchini R. 2 , Trevisani M. 1 , Abbate R. 1 , Cinotti S. 1 , Gensini GF. 1 , Masotti<br />
G. 1 , Geppetti P. 1<br />
1 Department of Critical Care Me<strong>di</strong>cine & Surgery, University of Florence, Florence, Italy;<br />
2 Department of Pharmacology, Chiesi Pharmaceuticals, Parma, Italy<br />
68. SERCA2 pump expression and phosphorilated phospholamban in mechanicalinduced<br />
ventricular hypertrophy in rats<br />
Popolo Ada, Morello S., 1 D’Emmanuele <strong>di</strong> Villa Bianca R., Marzocco S., 1 Sorrentino R., Autore<br />
G., Pinto A.<br />
Department of Pharmaceutical Sciences, University of Salerno; 1 Department of Experimental<br />
Pharmacology, University of Napoli “Federico II”<br />
120<br />
69. Nitric oxide donors: anti-aggregating effects and mechanisms of inhibition of<br />
platelet aggregation<br />
Priora Raffaella, Margaritis A., Frosali S., Summa D., Di Giuseppe D., Di Simplicio P.<br />
Department of Neuroscience, Pharmacology Unit, University of Siena<br />
70. Effects of hyperbaric oxygen therapy on thrombocytopenia and platelet aggregation<br />
during an experimental model of multiple organ failure syndrome<br />
Donniacuo Maria 1 , Rinal<strong>di</strong> B. 2 , Capuano A. 2 , Liguori G. 2 , Imperatore F. 2 , Cuzzocrea S. 3 ,<br />
Filippelli A. 2 , Rossi F. 2<br />
1 Doctorate in Pharmacological Sciences and Respiratory Physiopathology, Second University of<br />
Naples, Italy; 2 Department of Experimental Me<strong>di</strong>cine and Excellence Center of Car<strong>di</strong>ovascular<br />
Disease, Second University of Naples, Italy; 3 Department of Clinical and Experimental<br />
Me<strong>di</strong>cine and Pharmacology, University of Messina, Italy<br />
71. Proximal and <strong>di</strong>stal effects of arteriotomy in rat carotids: an extensive microarray<br />
analysis of gene expression<br />
1 Finicelli Mauro, 1 Forte A., 4 De Luca P., 2 Santè P., 2 Quarto C., 3 Onorati F., 3 Renzulli A.,<br />
1 Galderisi U., 2 Cotrufo M., 1 Cipollaro M., 1 Cascino A., 1 Rossi F., 1 Berrino L.<br />
Dept. of 1 Exp. Me<strong>di</strong>cine and 2 Car<strong>di</strong>othoracic Sciences, Second University of Naples; 3 Unit of<br />
Car<strong>di</strong>ac Surgery, University Magna Graecia, Catanzaro; 4 BIOGEM S.c.a.r.l., Ariano Irpino<br />
72. Effect of carbon nanotubes on human platelets<br />
Russier Julie § , Togna A. R. § , Togna G. I § , Serafino A.*, Almairac R.**, Fiorito S. <br />
§ Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”;<br />
*Institute of Neurobiology and Molecular Me<strong>di</strong>cine, CNR, Rome; **Laboratoire des Colloides,<br />
Verres, et Nanomateriaux,CNRS - University of Montpellier II; Department of Experimental<br />
Me<strong>di</strong>cine University of Rome “La Sapienza” - CNR<br />
pag_sx.indd 1 01/06/2007 15.29.05
Farmaci per la riduzione del rischio car<strong>di</strong>ovascolare<br />
Poster 73 – 80<br />
73. Antiatherosclerotic properties of everolimus: in vitro and in vivo stu<strong>di</strong>es<br />
Corsini A., Bellosta S., Baetta R., Ferri N., Arnabol<strong>di</strong> L., Canavesi M., Pfister P.*,Granata A.,<br />
Dorent R.*<br />
Department of Pharmacological Sciences, University of Milan, Milan, Italy; *Novartis Pharma<br />
AG, Basel, Switzerland<br />
74. Infection and atherosclerosis: simvastatin lowers the risk of developing<br />
atherosclerosis by limiting coxsackievirus B infection and the expression of proinflammatory<br />
markers in human vascular endothelial cells<br />
Ferioli Elena*, Bottelli A.*, Armocida G.*, Conal<strong>di</strong> P.G.°<br />
*Department of Me<strong>di</strong>cine and Public Health, University of Insubria, Varese, Italy; °ISMETT,<br />
Palermo, Italy<br />
75. In vivo stimulation of LXR increases the efflux potential of sera and promotes the<br />
reverse cholesterol transport<br />
Zanotti Ilaria, Potì F., Pedrelli M., Favari E., Calabresi L.*, Moleri E.*, Bernini F.<br />
Dept. of Pharmacological and Biological Sciences and Applied Chemistries, University of<br />
Parma, Parma, and *Center E. Grossi Paoletti, Dept. of Pharmacological Sciences, University<br />
of Milan, Milan<br />
76. Role of mesna to reduce homocysteine levels through SH/SS exchange reaction:<br />
possible therapeutical applications in hyperhomocysteinemic patients<br />
Di Giuseppe Daniele, Frosali S., Priora R., Margaritis A., Summa D., Di Simplicio P.<br />
Department of Neuroscience, Pharmacology Unit, University of Siena<br />
121<br />
77. Protein-thiol substitution or protein dethiolation by SH/SS echange reactions: the<br />
albumin model<br />
Di Simplicio Paolo, Summa D., Ottavia S., Priora R., Frosali S., Margaritis A., Di Giuseppe D.,<br />
Niccolai N.<br />
Department of Neuroscience, Pharmacology Unit, and Dept of Molecular Biology, University of<br />
Siena, 53100 Siena, Italy; *Department of Molecular Biology, University of Siena, 53100<br />
Siena, Italy<br />
78. Flaxseed oil supplementation increases plasma and tissue concentrations of ( -3)<br />
fatty acids in rats<br />
Notarangelo Francesca § , Avallone R. § , Rustichelli C. # , Campioli E. § , Braghiroli D. # , Baral<strong>di</strong> M. §°<br />
§ Department of Biome<strong>di</strong>cal Sciences, # Department of Pharmaceutical Sciences, Via Campi<br />
287, 41100 Modena, Italy, Pharmacology, °National InterUniversity Consortium for the Study<br />
of Natural Active Principles (CINSPAN)<br />
79. Synthesis and preliminary biological evaluation of new partially fluorinated thiol<br />
dual inhibitors of neutral endopeptidase 24.11 and angiotensin converting enzyme<br />
Tambaro Simone a , Olimpieri F. b , Lazzari P. a , Volonterio A. b , Pittau B. a , Pani L. a,c , Zanda M b<br />
a Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />
(CA), Italy; b C.N.R. Istituto <strong>di</strong> Chimica del Riconoscimento Molecolare, Via Mancinelli 7,<br />
20131 Milano, Italy; d C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o<br />
Neuroscienze PharmaNess S.c.a r.l.<br />
80. Car<strong>di</strong>oprotective activity of sidenafil in rats with chronic nitric oxide synthase<br />
inhibition<br />
Manfre<strong>di</strong> Barbara, De Gennaro Colonna V., Berti F., Rossoni G.<br />
Department of Pharmacology, Chemotherapy and Me<strong>di</strong>cal Toxicology, University of Milan,<br />
Italy<br />
pag_dx.indd 1 30/05/2007 5.15.49
Farmacologia del sistema nervoso<br />
Poster 81 – 110<br />
81. Nociceptin/Orphanin FQ-induced inhibition of electrical activity in dorsal raphe<br />
nucleus slices from normal and stressed rats<br />
Siniscalchi Anna, Barbieri M., Nazzaro C., Beani L.<br />
Department of Clinical and Experimental Me<strong>di</strong>cine University of Ferrara, Via Fossato <strong>di</strong><br />
Mortara, 17-19; 44100 Ferrara<br />
82. Pharmacological characterization of the Nociceptin/Orphaninn FQ receptor<br />
antagonist SB-612111: in vivo stu<strong>di</strong>es<br />
1 Rizzi Anna, 1 Gavioli E., 1 Marzola G., 1 Spagnolo B., 1 Zucchini S., 2 Ciccocioppo R., 3 Trapella C.,<br />
1 Regoli D., 1 Calo’ G.<br />
1 Dept. of Pharmacology and 3 Dept of Pharmaceutical Science, University of Ferrara, Italy;<br />
2 Dept. of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy<br />
83. Functional antagonism between Nociceptin/Orphanin FQ (N/OFQ) and CRF in the<br />
rat brain: evidence for involvement of the bed nucleus of the stria terminalis<br />
Ro<strong>di</strong> Donata (1) , Zucchini S. (1) , Simonato M. (1) , Cifani C. (2) , Massi M. (2) , Polidori C. (2)<br />
1)<br />
Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Section, and Neuroscience<br />
Centre, University of Ferrara; 2) Department of Experimental Me<strong>di</strong>cine and Publich Health,<br />
University of Camerino<br />
122<br />
84. Anticonvulsant effects of orphanin FQ on seizures induced by pentylenetetrazole<br />
Di Giannuario Amalia 1 , Colucci M. 1 , Maione F. 1,2 , Mascolo N. 2 , Pieretti S. 1<br />
1 Department of Drug Research and Evaluation, Istituto Superiore <strong>di</strong> Sanità, V.le Regina Elena<br />
299 - 00161 Rome. 2 Department of Experimental Pharmacology, University of Naples Federico<br />
II, Via Domenico Montesano 49 - 80131 Naples<br />
85. Effect of novel Nociceptin/Orphanin FQ-NOP receptor ligands on food intake in<br />
wistar rats<br />
Cifani Carlo a , Polidori C. a , Calò G. b , Massi M. a<br />
a Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, I-62032,<br />
Camerino, Italy; b Department of Experimental and Clinical Me<strong>di</strong>cine, Section of Pharmacology<br />
and Neuroscience Center, University of Ferrara, I-44100 Ferrara, Italy<br />
86. Chronic i.c.v. Treatment with [Nphe 1 , Arg 14 , Lys 15 ] N/OFQ-NH 2 (UFP-101), a potent<br />
nop receptor antagonist, reverses behavioural and biochemical effects of chronic<br />
mild stress in rats<br />
Vitale Giovanni a , Ruggieri V. a , Frigeri C. a , Filaferro M. a , Guerrini R. b , Massi M. c<br />
a Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, University of Modena and<br />
Reggio Emilia; b Department of Pharmaceutical Sciences , University of Ferrara; c Department<br />
of Pharmacological Sciences and Experimental Me<strong>di</strong>cine, University of Camerino<br />
87. Nociceptin/Orphanin FQ and food intake in <strong>di</strong>sease-prone WOKW and <strong>di</strong>seaseresistant<br />
DA rats<br />
a Cifani Carlo, a Filippetti R., b Kloting I., a Massi M., a Polidori C.<br />
a Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, I-62032<br />
Camerino, Italy - b Department of Laboratory Animal Science, Me<strong>di</strong>cal Faculty, University of<br />
Greifswald, D-17495 Karlsburg, Germany<br />
pag_sx.indd 1 30/05/2007 5.36.18
88. The neuro<strong>di</strong>fferentiative effect of estrogen involves nuclear receptors and is<br />
me<strong>di</strong>ated by TGF-<br />
Merlo Sara 1,2 , Canonico P.L. 2 , Copani A. 3 , Sortino M.A. 1<br />
Departments of 1 Experimental and Clinical Pharmacology and 3 Pharmaceutical Sciences,<br />
University of Catania, and 2 DISCAFF, University of Piemonte Orientale, Novara<br />
89. Erythropoietin inhibts the release, but not synthesis, of corticotropin-releasing<br />
hormone from rat hypothalamic explants in vitro<br />
Tringali Giuseppe, Lisi L., Pozzoli G., Navarra P.<br />
Institute of Pharmacology, Catholic University Me<strong>di</strong>cal School, Rome, Italy<br />
90. Neurochemical effects of post-weaning social isolation in adult rat brain<br />
Colaianna Marilena (a) , De Giorgi A. (a) , Cuomo V. (b) , Trabace L. (a)<br />
(a) Dept. Biome<strong>di</strong>cal Sciences, University of Foggia, Foggia, Italy; (b) Dept. of Human Physiology<br />
and Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy<br />
91. Strain-dependent levels of biogenic amine in post-weaning socially-isolated rats<br />
Castrignanò Silvia (a) , Zotti M. (a) , Cuomo V. (b) , Trabace L. (a)<br />
(a) Dept. of Biome<strong>di</strong>cal Sciences, University of Foggia; (b) Dept. of Human Physiology and<br />
Pharmacology, Vittorio Espamer, University of Rome La Sapienza, Rome, Italy<br />
92. Selective volume reduction of anterior cingulate cortex in young adult rats after<br />
neonatal excitotoxic lesion of ventral hippocampus<br />
Casu Gianluca * , Marchese G. * , Casti P. * , Pinna Spada G. * , Pani L. *<br />
§* Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />
(CA), Italy; § C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o Neuroscienze<br />
PharmaNess S.c.a r.l.<br />
123<br />
93. Acute but not chronic treatment with olanzapine reduces experimental anxiety in<br />
rats: possible mechanisms<br />
Locchi Federica, Rimon<strong>di</strong>ni R., Dall’Olio R., Gandolfi O.<br />
Department of Pharmacology, University of Bologna, 40128 Bologna, Italy<br />
94. Gender <strong>di</strong>fferences on long term effects of rat prenatal stress on dorsal and ventral<br />
hippocampal metabotropic glutamate receptors and anxiety behaviour<br />
Zuena Anna Rita 1,2 , Casolini P. 1 , Mairesse J. 1,2 , Cinque C. 1 , Matteucci P. 1 , Alemà G.S. 1 , Morley-<br />
Fletcher S. 2 , Catalani A. 1 , Nicoletti F. 1,3 , Maccari S. 2<br />
1 Dept of Human Physiology and Pharmacology, Univesity of Rome “La Sapienza”, Italy; 2 Lab<br />
of Perinatal Stress, University of Lille 1, France; 3 INM Neuromed, Pozzilli, Italy<br />
95. Post-natal repeated mild stress induces changes in brain NAD(P)H recycling in adult<br />
male mice: role of the opioid system<br />
Loizzo Stefano, Guarino I., Galietta G., Fortuna A., Loizzo A., Spampinato S., Campana G.,<br />
Capasso A., Franconi F.<br />
Section of Drugs and Health for the Child and the Woman, Dept of Drug Research and<br />
Evaluation, and National Centre for Rare Diseases, Istituto Superiore <strong>di</strong> Sanita’, Roma, Dept<br />
of Pharmacology, University of Bologna, Dept of Pharmacology, University of Salerno, Dept of<br />
Pharmacology and Centre of Excellence for Biotechnology and Bio<strong>di</strong>versity University of<br />
Sassari, and GIOIA Foundation<br />
96. Changes in hippocampal gene expression profile following acute and chronic stress<br />
in the mouse<br />
Ubal<strong>di</strong> Massimo 1 , Lourdusamy A. 1 , Soverchia L. 1 , Cippitelli A. 1 , Ruggeri B. 1 , Har<strong>di</strong>man G. 2 ,<br />
Ciccocioppo R. 1<br />
1 Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino Italy;<br />
2 Department of Me<strong>di</strong>cine, University of California San Diego, CA, USA<br />
pag_dx.indd 1 30/05/2007 5.33.54
97. Treatment of premenstrual syndrome with continuous low dosage sertralin<br />
Tammaro Emanuela*, Milano W., Milano L., Rundle-Smith S., Petrella C., Capasso A.*<br />
Mental Health Operations Unit District 44 ASL Napoli 1 and *Department of Pharmaceutical<br />
Sciences, University of Salerno, Italy<br />
98. Novel therapeutic opportunities in unipolar depression<br />
Corsi Mauro, W.P.<br />
Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithkline S.p.A., Verona, Italy<br />
99. Lifestyle interventions on bodyweight gain olanzapine-induced: result from a<br />
randomized-controlled trial<br />
Cammarano Michela*, Milano W., Comazzi M.°, Milano L., Petrella C., Capasso A.*<br />
Unità Operativa Salute Mentale Distretto 44 ASL Napoli1; * Department of Pharmaceutical<br />
Sciences, University of Salerno, Italy; ° Unità <strong>di</strong> Psichiatria Azienda Ospedaliera <strong>di</strong> Melegnano<br />
Milano<br />
124<br />
100. Tolerability of antipsychotics in children and adolescents: a prospective study<br />
Alacqua Marianna 1 , Trifirò G. 1,4 , Arcoraci V. 1 , Germanò E. 2 , Gagliano A. 2 , Siracusano M. 2 , Di<br />
Vita G. 3 , Gagliano C. 3 , Spina E. 1, 4<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Pharmacology Unit,<br />
University of Messina, Italy - 2 Division of Child Neurology and Psychiatry, University of<br />
Messina, Italy - 3 Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS),<br />
Troina, Italy; 4 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy<br />
101. Plasma concentrations of quetiapine during coadministration with antiepileptic<br />
drugs in psychiatric patients<br />
D’Arrigo Concetta 1 , Migliar<strong>di</strong> G. 1 , Santoro V. 2 , Muscatello M.R. 3 , Zoccali R. 3 , Spina E 1,2<br />
1 Section of Pharmacology, Department of Clinical and Experimental Me<strong>di</strong>cine and<br />
Pharmacology, 2 IRCCS Centro Neurolesi “Bonino-Pulejo” and 3 Department of Neurosciences,<br />
Psychiatric and Anesthesiological Sciences, University of Messina, Messina, Italy<br />
102. Potential application of testosterone metabolites in the treatment of<br />
adrenoleukodystrophy<br />
Carissimi Romina 1 , Blasevich M. 1 , Cappa M. 2 , Uziel G. 3, Petroni A. 1<br />
1 Depart. of Pharmacological Sciences, University of Milan, via Balzaretti 9, 20133 Milan, Italy;<br />
2 Depart. of Pe<strong>di</strong>atrics Me<strong>di</strong>cine, Children’s Hospital “Bambino Gesù”, IRCCS, Rome, Italy;<br />
3 Child Neurology Dep., Istituto Neurologico “C. Besta”, Milan, Italy<br />
103. Development of specific biomarkers for als clinical progression: validation and<br />
potential roles in pathogenesis<br />
Bonini Sara A. 1 , Zhao Z. 2 , Lange D. J 3 ., Ho L. 2 , Yemul S. 2 , Wang J. 2 , Salton S. 4 , Memo M. 1 ,<br />
Pasinetti G.M. 2<br />
1 Department of Biome<strong>di</strong>cal Sciences and Biotechnologies, University of Brescia, Brescia, Italy;<br />
2 Department of Psychiatry, 3 Department of Neurology, 4 Department of Neuroscience, Mount<br />
Sinai School of Me<strong>di</strong>cine, New York, New York, USA<br />
pag_sx.indd 1 30/05/2007 5.37.18
104. Functional heterogeneity of histaminergic neurons suggest interesting applications<br />
of GSK189254, a novel H 3 receptor antagonist<br />
Giannoni Patrizia 1 , Passani M.B. 1 , Nosi D. 2 , Medhurst A.D. 3 , Chazot P. 4 , Shenton F. 4 ,<br />
Blan<strong>di</strong>na P. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia Preclinica and Clinica, 2 Dipartimento <strong>di</strong> Anatomy Universita’ <strong>di</strong><br />
Firenze Italy, 3 Neurology Centre of Excellence for Drug Discovery,GlaxoSmithKline,Essex<br />
CM19 5AW, UK, 4 Centre for Integrative Neuroscience, School of Biological and Biome<strong>di</strong>cal<br />
Sciences, Durham University, UK<br />
105. Improvements in long-term memory retention by inhibition of fatty acid amide<br />
hydrolase (FAAH) are me<strong>di</strong>ated by -type peroxisone proliferator-activated<br />
receptors (PPAR) And not by cannabinoid CB 1 receptors<br />
Mazzola C 1 , Medalie J. 1 , Panlilio L.V. 1 , Solinas M. 2 , Drago F. 3 , Goldberg S.R. 1 , Yasar S. 4<br />
1 Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural<br />
Research Program, NIDA, NIH, DHHS, Baltimore, MD, 21224, USA. 2 Department Laboratoire<br />
de Biologie et Physiologie Cellulaires, CNRS-6187, Université de Poitiers, 86022, Poitiers,<br />
France. 3 Department of Experimental and Clinical Pharmacology, Me<strong>di</strong>cal School, University of<br />
Catania, Italy. 4 Division of Geriatric Me<strong>di</strong>cine, Johns Hopkins Me<strong>di</strong>cal School, Baltimore, MD,<br />
21224, USA<br />
106. Tricyclic pyrazoles. Synthesis and biological evaluation of novel 4,5-<strong>di</strong>hydro-1H-6-<br />
oxa-cyclohepta[1,2-c]pyrazole-based analogues of cannabinoid antagonist NESS<br />
0327<br />
Dessì Christian ‡ , Murineddu G. † , Ruiu S. ‡ , Loriga G. † , Manca I. † , Lazzari P. ‡ , Pau A. † ,<br />
Reali R. ‡ , Pinna G.A. † , Pani L. ‡,§<br />
‡ Neuroscienze PharmaNess S.c.a r.l., c/o POLARIS, E<strong>di</strong>ficio 5, Loc.Piscinamanna, 09010 Pula<br />
(CA), Italy; † Dipartimento Farmaco Chimico Tossicologico, Università <strong>di</strong> Sassari, Via F. Muroni<br />
23/A, 07100 Sassari, Italy; § C.N.R. Istituto <strong>di</strong> Tecnologie Biome<strong>di</strong>che, Sezione <strong>di</strong> Cagliari, c/o<br />
Neuroscienze PharmaNess S.c.a r.l.<br />
125<br />
107. Early and late post-mortem neural stem cells grow and <strong>di</strong>fferentiate in vitro. A novel<br />
source for cellular therapy<br />
Madaschi Laura 1* , Marfia G. 1* , Cigognini D. 1 , Bottai D. 1,2 , Di Giulio A.M. 1 , Gorio A. 1,2<br />
1) Dept. of Me<strong>di</strong>cine, Surgery and Dentistry, Faculty of Me<strong>di</strong>cine, University of Milan, Italy;<br />
2) Clinical Pharmacology IRCCS Humanitas, Milan, Italy; *These two authors equally<br />
contributed at this work<br />
108. Calcineurin primes GnRH-secreting neurons for migration<br />
Zaninetti Roberta, Tacchi S., Erriquez J., Distasi C., Maggi R.*, Canonico P.L., Genazzani A.A.<br />
Dipartimento <strong>di</strong> Scienze Chimiche, Alimentari, Farmaceutiche Farmacologiche, Drug and Food<br />
Biotechnology Center, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> del Piemonte Orientale “A. Avogadro”, Novara<br />
*Laboratorio <strong>di</strong> Neuroendocrinologia dello Sviluppo, Istituto <strong>di</strong> Endocrinologia, CEND,<br />
Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano<br />
109. Peptide-derivatized nanoparticles as carriers of drugs into the central nervous<br />
system<br />
Tacchi Raffaella 1 , Vergoni A.V. 3 , Tosi G. 4 , Costantino L. 4 , Rivasi F. 2 , Bertolini A. 1 , Ruozi B. 4 ,<br />
Forni F. 4 , Vandelli M.A. 4<br />
Departments of: Diagnostic and Laboratory Services, Section of Clinical Pharmacology 1 and<br />
Section of Pathological Anatomy 2 ; Biome<strong>di</strong>cal Sciences, Section of Pharmacology 3 ;<br />
Pharmaceutical Sciences 4 ; University of Modena and Reggio Emilia<br />
110. Standar<strong>di</strong>zed analysis of c-fos mRNA expression pattern in rat brain<br />
autora<strong>di</strong>ography using freeware imaging software<br />
Dipasquale Pasqua, Celentano M., Righetti L., Lucchino I., Gaetani S., Cuomo V.<br />
Department of Human Physiology and Pharmacology, University of Rome “La Sapienza”<br />
pag_dx.indd 1 30/05/2007 5.42.56
Farmacologia dei processi degenerativi<br />
Poster 111 – 132<br />
111. GPR17: a new dual receptor for both extracellular nucleotides and cysteinylleucotrienes<br />
involved in brain ischemia<br />
Gelosa Paolo 1 , Sironi L.i 1 , Guerrini U. 1 , Tremoli E. 1,2 , Enrico R. 1 , Patrizia Rosa 3 , Lecca D. 1 ,<br />
Pignieri A. 1 , Abbracchio M. P 1* , Cimino M. 4*<br />
1 Department of Pharmacological Sciences, University of Milan, Italy - 2 Monzino Car<strong>di</strong>ologic<br />
Centre IRCCS, Milan, Italy - 3 CNR Institute of Neuroscience, Cellular and Molecular<br />
Pharmacology, Milan, Italy - 4 Institute of Pharmacology and Pharmacognosy, University of<br />
Urbino, Italy; *equally contributed to the present work<br />
112. Apomorphine-induced neurodegeneration in Mongolian gerbil hippocampus<br />
Russo E. 1 , Donato G. 1 , De Fazio S. 1 , De Fazio P. 1 , Perrotta I. 2 , De Sarro G. 1<br />
1 Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of Me<strong>di</strong>cine and Surgery,<br />
University of Catanzaro, Catanzaro, Italy; 2 Ecology Department, University of Calabria,<br />
Cosenza, Italy.<br />
126<br />
113. Blunted HPA axis activity during ischemia protects adult rats neonatally exposed to<br />
glucocorticoids against brain damage<br />
Cinque Carlo 1 , Mairesse J. 3 , Casolini P. 1 , Domenici M. R. 2 , Galluzzo M. 2 , Musumeci M. 2 , Alemà<br />
G. S. 1 , Zuena A. R. 1 , Matteucci P. 1 , Maccari S. 3 , Nicoletti F. 1,4 , Catalani A. 1<br />
1. Dep. of Human Physiol & Pharmacol, University “Sapienza”, Rome, Italy; 2. Dep. of<br />
Pharmacol, Istituto Superiore <strong>di</strong> Sanità, Rome, Italy; 3. Lab. Perinatal Stress, JE2365.<br />
University of Lille 1, 59655 Villeneuve d’Ascq, France; 4. INM Neuromed, Pozzilli, Italy<br />
114. Knocking-down and knocking-out of NCKX2 gene expression exacerbate the brain<br />
insult induced by focal ischemia<br />
Cuomo Ornella, Pignataro G., Gala R., Boscia F., Tortiglione A., Valsecchi V., Di Renzo GF.,<br />
Lytton J.* , Annunziato L.<br />
Division of Pharmacology, Department of Neuroscience, School of Me<strong>di</strong>cine, , Federico II<br />
University of Naples, Via S. Pansini 5, 80131 Naples, Italy. *Department of Biochemistry and<br />
Molecular Biology University of Calgary, Calgary, Alberta, Canada<br />
115. Neuroprotective effect of melanocortins in focal cerebral ischemia<br />
Giuliani Daniela 1 , Ottani A. 1 , Mioni C. 1 , Galantucci M. 1 , Bazzani C. 1 , Zaffe D. 2 , Bitto A. 3 ,<br />
Minutoli L. 3 , Botticelli A. R. 4 , Altavilla D. 3 , Squadrito F. 3 , Guarini S. 1<br />
1 Dept. Biome<strong>di</strong>cal Sci., Sect. Pharmacology, and 2 Dept. Anatomy and Histology, University of<br />
Modena and Reggio Emilia; 3 Dept. Clin. Exp. Med. Pharmacol., Sect. Pharmacology, University<br />
of Messina; 4 Dept. Human Pathology, University of Pavia<br />
116. Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration<br />
related to temporal lobe epilepsy<br />
Biagioni Francesca 1 , Busceti C.L. 1 , Aronica E. 2* , Storto M. 1 , Battaglia G. 1 , Giorni F.S. 3 , Fornai<br />
F. 1,3 , Gra<strong>di</strong>ni R. 4 , Caricasole A. 5 , Nicoletti F. 1,6 , Bruno V. 1,6<br />
1 I.N.M. Neuromed, Pozzilli, Italy; 2 Dept. of Neuropathol., Univ. of Amsterdam, The<br />
Netherland; 3 Dept. of Hum. Morphol., Univ. of Pisa, Italy; 5 SienaBiotech, Siena, Italy; 5 Dept.<br />
of Exp. Med. and 6 Hum. Physiol. And Pharmacol. , Univ. “La Sapienza”, Rome, Italy<br />
117. Stimulation of proteinase-activated receptors 1 and 2 induces neurodegeneration in<br />
the rat olfactory system<br />
Dedoni Simona, Olianas M.C., Garau L., Onali P.<br />
Section of Biochemical Pharmacology, Department of Neuroscience, University of Cagliari,<br />
Cagliari, Italy.<br />
pag_sx.indd 1 30/05/2007 5.44.38
118. Histone deacetylase (HDAC) inhibitors reduce the in vitro and in vivo<br />
neuroinflammatory response in mice<br />
Faraco Giuseppe, Fossati S., Formentini L., *Mascagni P., *Fossati G., *Leoni F., Moroni F.,<br />
Chiarugi A.<br />
Dipartimento <strong>di</strong> Farmacologia Clinica e Preclinica, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Firenze<br />
*Italfarmaco S.p.a., Milan, Italy<br />
119. Neuroprotection by 17-estra<strong>di</strong>ol in whole rat urinary bladder subjected to<br />
ischaemia/reperfusion injury<br />
Valeri Aurora, Pessina F., Sgaragli G.<br />
Dip. Scienze Biome<strong>di</strong>che, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena, Via Aldo Moro 2 , 53100 Siena<br />
120. Heme oxygenase activity in immortalized hypothalamic neurons GT1-7<br />
Mores Na<strong>di</strong>a, Mancuso C., Errico S., Barone E., Preziosi P.<br />
Istituto <strong>di</strong> Farmacologia – Facoltà <strong>di</strong> Me<strong>di</strong>cina e Chirurgia<br />
Università Cattolica del Sacro Cuore - Roma<br />
121. Spinal cord injury and neural precursors. Homing, fate and recovery of function<br />
Bottai Daniele 1,2 , Maraschi L. 1 , Di Giulio A. M. 1 , Gorio A. 1,2 .<br />
1) Department of Me<strong>di</strong>cine, Surgery and Dentistry, University of Milan, Via A. <strong>di</strong> Ru<strong>di</strong>nì 8,<br />
20142 Milano, Italy; 2) Clinical Pharmacology IRCCS Humanitas Via Manzoni 56, 20089<br />
Rozzano, Milano, Italy.<br />
122. Melatonin protects from the long-term morphological and functional consequences<br />
of a neonatal hypoxic-ischemic brain injury in rats<br />
Carloni Silvia, Buonocore G. 1 , Perrone S. 1 , Longini M. 1 , Proietti F. 1 , Balduini W.<br />
Istituto <strong>di</strong> Farmacologia e Farmacognosia, Università <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urbino “Carlo Bo”, Via S.<br />
Chiara 27, Urbino; 1 Dipartimento <strong>di</strong> Pe<strong>di</strong>atria, Ostetricia e Me<strong>di</strong>cina della Riproduzione,<br />
Sezione <strong>di</strong> Neonatologia Università <strong>di</strong> Siena, Policlinico Le Scotte Via M. Bracci, Siena<br />
127<br />
123. Pentoxifylline ameliorates calcium homeostasis and improves regeneration in<br />
skeletal muscle of dystrophic mdx mice: a comparison with the effects of a<br />
combined treatment prednisolone-taurine<br />
Bur<strong>di</strong> Rosa 1 , Rolland J.-F. 1 , Cozzoli A. 1 , Giannuzzi V. 1 , Liantonio A. 1 , Camerino G. M. 1 ,<br />
Andretta F. 2 , Confalonieri P. 2 , Mangieri D. 3 , Nico B. 3 , De Luca A. 1<br />
1 Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of<br />
Bari, Italy; 2 Muscular Pathology Unit, National Neurological Institute Carlo Besta, Milan, Italy,<br />
3 Department of Human Anatomy and Histology, University of Bari, Italy<br />
124. Effect of a chronic treatment with gentamicin on in vivo and ex vivo markers of<br />
dystrophic progression in mdx mouse<br />
Cozzoli Anna 1 , Bur<strong>di</strong> R. 1 , Cippone V. 1 , Nicchia G. P. 2 , Frigeri A. 2 , Camerino G.M. 2 , Mangieri<br />
D. 3 , Nico B. 3 , De Luca A. 1<br />
1 Dept. of Pharmacobiology, Faculty Pharmacy and 2 Dept. of General and Environmental<br />
Physiology, 3 Department of Human Anatomy and Histology, University of Bari, Italy<br />
125. VEGF overexpression via adeno-associated virus gene transfer promotes skeletal<br />
muscle regeneration and enhances muscle function in mdx mice<br />
Di Stefano Vincenzo 1 , Bitto A. 1 , Minutoli L. 1 , Altavilla D. 1 , Messina S. 2 , Vita G. 2 , Giacca M. 3 ,<br />
Caputi A.P. 1 , Squadrito F. 1<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, University of Messina,<br />
2 Dept of Neurosci, Psych and Anaesthesiol, University of Messina, 3 Mol Med Lab, International<br />
Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy<br />
pag_dx.indd 1 30/05/2007 5.45.36
126. Possible antioxidant effect of sulphur mud- bath therapy in treatment of<br />
osteoarthrosis<br />
1,2 Costantino Maria, 2 Lampa E., 3 Giuberti G., 3 Caraglia M., 3 Abbruzzese A., 2 Filippelli A.<br />
1 CE.RI.S.T. (Center of Thermal Researches and <strong>Stu<strong>di</strong></strong>es srl), Naples, Italy; 2 Department of<br />
Experimental Me<strong>di</strong>cine–Pharmacological Division, II University of Naples-Italy; 3 Department of<br />
Biochemistry and Biophysics “F. Cedrangolo” – II University of Naples, Naples, Italy<br />
127. Bilirubin modulates neurotrophin redox signaling<br />
Mancuso Cesare 1 , Eboli M.L. 2 , Calabrese V. 3 , Preziosi P. 1 , Galeotti T. 2 , Pani G. 2<br />
From the Institutes of 1 Pharmacology and 2 General Pathology, Catholic University School of<br />
Me<strong>di</strong>cine, Largo F. Vito, 1 - 00168 Roma, Italy; 3 Dept. of Chemistry, Biochemistry and Mol.<br />
Biology Section, Faculty of Me<strong>di</strong>cine, University of Catania, 95100, Catania, Italy<br />
128. A study on biological activities of cyani<strong>di</strong>n-3-O-glucoside related to its antioxidant<br />
properties<br />
1 Speciale A., 1 Cimino F., 1 Chirafisi J., 1 Cristani M., 2 Ermito S., 1 Spinzia C., 1 Saija A.<br />
1 Dept. Farmaco-Biologico, School of Pharmacy, University of Messina - Vill. SS. Annunziata<br />
98168 Messina, Italy. 2 Institute of Gynecology and Obstetrics, University of Messina, Italy<br />
128<br />
129. Protective effect of Mn(III) tetrakis (4-benzoic acid) porphyrin on the inactivation<br />
of primary antioxidant enzymes in keratinocytes by photodynamically generated<br />
free ra<strong>di</strong>cals<br />
Muscoli Carolina 1 , Nistico’ S. 2 , Arcone R. 1 , Colica C. 1 , Visalli V. 1 , Vetrice D. 1 , Casale F. 1 , Del<br />
Vecchio I. 3 , Strangoli M.C. 3 , Mollace V. 1 , Rotiroti D. 3<br />
1 Dept of Pharmacobiol. Sciences, University of Catanzaro Magna Graecia, Italy; 2 School of<br />
Me<strong>di</strong>cine, Univesity of Rome “Tor Vergata”; 3 ISN-CNR<br />
130. Anticataractogenic property of -glutamylcysteine ethyl ester in an animal model of<br />
cataract<br />
Pannini Simone, Barberi L., Leone R. L, Casini P.<br />
Department of Farmacology “G. Segre”, University of Siena<br />
131. Assessment of blood and salivary antioxidant system in subjects with periodontitis<br />
and peri-implantitis<br />
Fiaschi Anna Ida, *Ruggero G., De Vuono G., Cerretani D., *Cozzolino A.<br />
Department of Pharmacology “G. Segre”, * Department of Odontostomatologic Science,<br />
Maxillo-Facial Surgery Division, University of Siena<br />
132. Status of lipid peroxidation in patients with osteoarthritis underwent a tammef<br />
system<br />
Fiaschi Anna Ida, *Battisti E., *Albanese A., Cerretani D., Runci F.<br />
Department of Pharmacology “G. Segre”, * Centre TAMMEF, University of Siena<br />
Farmacologia del dolore<br />
Poster 133 – 144<br />
133. Repeated treatment with AM404 reduces mechanical allodynia and thermal<br />
hyperalgesia in a model of neuropathic pain without central effects<br />
Sasso Oscar, La Rana G., Russo R., D’Agostino G., Iacono A., Meli R., Calignano A.<br />
Dep Experimental Pharmacology, Faculty of Pharmacy, via D. Montesano 49-Naples<br />
pag_sx.indd 1 30/05/2007 5.46.40
134. Antihyperalgesic and antiallodynic effect of purinergic antagonists in a mouse<br />
model of mononeuropathy: neuroinflammatory involved mechanisms<br />
Trovato Anna Elisa 1 , Franchi S. 1 , Magnaghi V. 2 , Panerai A. E. 1 , Procacci P. 4 , Rodella L. F. 3 ,<br />
Sacerdote P. 1 , Valsecchi A. E. 1 , Colleoni M. 1<br />
1 Dep. Pharmacol. Chem. Med. Toxicol, Univ. of Milan, 2 Dep. Endocrinol, Center Excell.<br />
Neurodegen. Dis., Univ. of Milan, 3 Divis. Anat., Dep. Biome<strong>di</strong>c. Sci. Biotechnol., Univ. of<br />
Brescia, 4 Inst. Histol. Embriol. Neurocytol., Univ. of Milan<br />
135. Phytoestrogen genistein reduces nociceptive hypersensitivity in the mouse chronic<br />
constriction injury model<br />
Valsecchi Anna E., Franchi S., Panerai A. E., Sacerdote P., Trovato A. E. , Colleoni M.<br />
Departement of Pharmacology, Chemoterapy and Me<strong>di</strong>cal Toxicology, University of Milan<br />
136. Blockade of the TRPV1 receptor and of the fatty acid amide hydrolase enzyme in a<br />
mouse model of neuropathic pain prevents pain-like behaviour and caspases<br />
activation<br />
Giordano Catia, Siniscalco D., Migliozzi A., Rossi F., Di Marzo V.°, Maione S.<br />
Istituto <strong>di</strong> Chimica Biomolecolare, CNR, Pozzuoli (NA), Italy; Department of Experimental<br />
Me<strong>di</strong>cine, section of Pharmacology, Second University of Naples, Via S. Maria <strong>di</strong> Costantinopoli<br />
16 – 80138 Naples, Italy<br />
137. The fatty-acid amide hydrolase inhibitor URB597 reduces neuropathic pain after oral<br />
administration in mice<br />
Russo Roberto, La Rana G., D’Agostino G., Sasso O., LoVerme J., Piomelli D., Malignano A.<br />
Department of Experimental Pharmacology, University of Naples, Italy.; Department of<br />
Pharmacology and the Center for Drug Discovery, University of California, Irvine<br />
138. N-arachidonoyl-serotonin: a fatty acid amide hydrolase inhibitor with antagonistic<br />
activity at TRPV1 receptors and analgesic properties in vivo<br />
Palazzo Enza 1 , De Petrocellis L. 2 , Petrosino S. 2 , Gatta L. 1 , Guida F. 1 , Ortar G. 3 , Rossi F. 1 ,<br />
Maione S. 1 , Di Marzo V. 2<br />
1 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “L. Donatelli”, Second<br />
University of Naples, via Costantinopoli 16, 80138 Naples. 2 Endocannabinoid Research Group,<br />
Institutes of Cybernetics and of Biomolecular Chemistry, CNR, Pozzuoli (Naples). 3 Dipartimento<br />
<strong>di</strong> <strong>Stu<strong>di</strong></strong> Farmaceutici, Università <strong>di</strong> Roma 'La Sapienza”, Roma<br />
129<br />
139. A novel pharmacological approach for the treatment of neuropathic pain: toll-like<br />
receptor 4 antagonists as modulators of activated microglia<br />
Costa Barbara, Comelli F., Peri F., Granucci F., Bettoni I., Rossini C., Giagnoni G.<br />
Department of Biotechnology and Bioscience, University of Milano-Bicocca<br />
140. Ethanol causes neurogenic vaso<strong>di</strong>latation by TRPV1 activation and CGRP release in<br />
the trigeminovascular system of the guinea pig<br />
Benemei S. 1 , Nicoletti P. 1 , Trevisani M. 2 , Manconi M. 3 , De Siena G. 1 , Zagli G. 1 , Capone J.A. 2 ,<br />
Geppetti P. 1 , Pini L.A. 4<br />
1 Clinical Pharmacology Unit, Department of Critical care Me<strong>di</strong>cine and Surgery, University of<br />
Florence, 2 Center of Excellence for the Study of Inflammation and Headache Center,<br />
University of Ferrara, Ferrara, 4 Department of Laboratory Me<strong>di</strong>cine and Forensic Me<strong>di</strong>cine,<br />
University of Modena and Reggio Emilia, Italy<br />
141. Insertion/deletion polymorphism of the Angiotensin I-Converting Enzyme gene in<br />
migraine patients<br />
Bisogno Angelina (3) , Pizza V. (1) , Volpe G. (1) , Infante F. (2) , Schiavo G. (2) , Lamaida E. (1) ,<br />
Agresta A. (1) , Bianchi A. (3) , Capasso A. (3)<br />
1) Neurophysiopatology 2) Molecular Biology, S. Luca Hospital, Vallo della Lucania (SA),<br />
3) University of Salerno, Italy<br />
pag_dx.indd 1 30/05/2007 5.47.33
142. Genetic polymorphisms and migraine<br />
Longobar<strong>di</strong> Francesca (3) , Pizza V. (1) , Volpe G. (1), Infante F. (2) , Lamaida E. (1) , Agresta A. (1) ,<br />
Bisogno A. (3) , Bianchi A. (3) , Capasso A. (3)<br />
(1) Neurophysiopatology Service; (2) Molecular Biology Service, S. Luca Hospital, Vallo della<br />
Lucania (SA), ASL SA/3; (3) Department of Pharmaceutical Sciences, University of Salerno,<br />
Italy.<br />
143. Long-term intrathecal morphine in patients with chronic non-cancer pain upregulates<br />
mu opiod receptor gene expression in lymphocytes<br />
Campana Gabriele 1 , Raffaeli W. 2 , Sarti D. 2 , Spampinato S. 1<br />
1 Dept. Of Pharmacology - University of Bologna-Irnerio 48 - 40126 – Bologna; 2 Pain and<br />
Palliative Care Unit, Infermi Hospital, Rimini -Via Ovi<strong>di</strong>o - 47900 - Rimini<br />
144. Comparative production of the active tramadol metabolite o-desmethyl-tramadol<br />
(m1) in domestic animal species<br />
Zonca Annalisa*, Cagnar<strong>di</strong> P.*, Villa R.*, Ravasio G. # , Vettorato E. $ , Isola M. $ , Montesissa C. §<br />
*Dipartimento <strong>di</strong> Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Milano;<br />
§ Dipartimento <strong>di</strong> Sanità Pubblica Patologia Comparata ed Igiene Veterinaria, Padova;<br />
# Dipartimento <strong>di</strong> Scienze Cliniche Veterinarie, Milano; $ Dipartimento <strong>di</strong> Scienze Cliniche<br />
Veterinarie, Padova<br />
Sostanze <strong>di</strong> abuso<br />
Poster 145 – 161<br />
130<br />
145. Effect of uncontingent and subchronic administration of ad<strong>di</strong>ctive drugs on neuronal<br />
plasticity in the rat nucleus accumbens<br />
Ibba Federico 1 , Vinci S. 1 , Spiga S. 2 , Acquas E. 1, 3 , Di Chiara G. 1, 3<br />
1 Department of Toxicology and 3 Centre of Excellence on Neurobiology of Ad<strong>di</strong>ction, University<br />
of Cagliari; 2 Department of Animal Biology and Ecology, University of Cagliari<br />
146. Trend of drugs of abuse detection in the urine of patients of the university hospital<br />
of modena, during the period 1997-2006<br />
Coccia Ciro, Ferrari A., Castellana C. N., Poppi B., Pisa S., Bertolini A., Sternieri E.<br />
Toxicology and Clinical Pharmacology Section. Department of Laboratory Services University<br />
of Modena and Reggio Emilia, Italy<br />
147. Difference in the degree of nicotine dependence and development of depression<br />
between cannabis users and polidrug users<br />
Russo Giuseppina A. 1 , Garuana A. 2 , Mannucci C. 1 , Tedesco M. 1 ,<br />
Calapai G. 1<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Section of<br />
Pharmacology, School of Me<strong>di</strong>cine, University of Messina, Italy; 2 Territorial Service for<br />
Ad<strong>di</strong>ction (Ser.T.) of the District of Ribera – Local Sanitary Unit USL n°1, Agrigento (Italy)<br />
148. The cannabinoid antagonist SR 141716A reduces the increase of extra-cellular<br />
dopamine release in the rat nucleus accumbens induced by a novel high palatable<br />
food<br />
Melis Tiziana, Sanna F., Succu S., Argiolas A., Melis M.R.<br />
Beranrd B. Bro<strong>di</strong>e Department of Neurosciences, University of Cagliari, Italy<br />
149. Cannabinoid self-administration in the rat: gender <strong>di</strong>fferences and effect of<br />
ovariectomy<br />
Spano M. Sabrina 1,3 , Fattore L. 2,3 , Altea S. 1 , Angius F. 1 , Fadda P. 1,3 1, 2,3<br />
, Fratta W. 1 Department of Neuroscience, University of Cagliari ; 2 Institute of Neuroscience CNR, Section<br />
of Cagliari; 3 Centre of Excellence "Neurobiology of Dependence", University of Cagliari<br />
pag_sx.indd 1 30/05/2007 5.48.33
150. Psychosis onset: use of cannabis x COMT genotype interaction. A case-only design<br />
analysis in a first-episode psychosis sample<br />
La Cascia Caterina 1,2 , Di Forti M. 2 , Murray R.M. 2 , La Barbera D. 1 , Butt A. 2 , Mondelli V. 2 ,<br />
Eyeson J. 2 , Navari S. 2 , Aas M. 2 , Clifford D. 2 , Dazzan P. 2 , Pariante C. 2 , Morgan C. 2 , Freeman<br />
B. 2 , Luzi S. 2 , Dempster D. 2 , Rivera M. 2 , Collier D. 2 , Powell J. 2 , Cannizzaro G. 3<br />
1 Dept. of Clinical Neurosciences, University of Palermo, 2 Institute of Psychiatry, King’s College<br />
London, UK, 3 Dept. of Pharmacological Sciences, University of Palermo<br />
151. Flumazenil selectively prevents the increase in 4 subunit gene expression and an<br />
associated change in GABA A receptor function induced by ethanol withdrawal<br />
Caria Stefania 1 , Biggio F. 1 , Gorini G. 1 , Murru L. 1 , Sanna E. 1,2 , Follesa P. 1,2 ,Biggio G. 1,2<br />
University of Cagliari, Department of Experimental Biology, Section of Neuroscience 1 ; Center<br />
of Excellence for the Neurobiology of Dependence 2 , 09123 Cagliari, Italy<br />
152. Pregnenolone sulfate enhancement of GABA release in the developing rat<br />
cerebellum is me<strong>di</strong>ated by presynaptic nmdars and is modulated by ethanol<br />
Carta Mario, Murru L., Vir<strong>di</strong>s F., Brockmann M.D., Marras R., Sanna E., Biggio G.<br />
Dept. Experimental Biology, Sect of Neuroscience, and Center of Excellence for the<br />
Neurobiology of Dependence. Cittadella Universitaria, SS 554 Km 4,500, 09042, Monserrato,<br />
Cagliari, Italy<br />
153. Neurosteroid-me<strong>di</strong>ated increase of GABAergic tonic inhibition in rat dentate gyrus<br />
granule cells by ethanol<br />
Sanna Enrico,Talani G., Zucca S., Biggio G.<br />
Dept. Experimental Biology, Sect. of Neuroscience, and Center of Excellence for the<br />
Neurobiology of Drug Dependence, University of Cagliari, Cittadella Universitaria, Monserrato,<br />
Cagliari, Italy<br />
131<br />
154. Activation of transient receptor potential vanilloid type 1 (TRPV1) by ethanol: role<br />
of endogenous lipid me<strong>di</strong>ators<br />
Campi B., Gatti R., Andre E., Geppetti P., Trevisani M.<br />
Inter<strong>di</strong>sciplinary Centre of Excellence for the Study of Inflammation (ICSI), University of<br />
Ferrara, Ferrara, Italy<br />
155. Transient receptor potential vanilloid 1, substance P & reactive oxygen species<br />
me<strong>di</strong>ate ethanol-induced gastric injury<br />
Trevisani M. 1 , Gazzieri D. 1 , Harrison S. 2 , Cottrell G.S. 5 , Andre E. 1 , Massi D. 3 , Zecchi S. 4 ,<br />
Lungarella G. 6 , Bunnett N.W. 5 , Geppetti P. 1,2<br />
1 Center of Excellence for the Study of Inflammation, University of Ferrara; Departments of<br />
2 Critical Care Me<strong>di</strong>cine and Surgery, 3 Human Pathology and Oncology, and 4 Anatomy,<br />
University of Florence; 5 Departments of Surgery and Physiology, University of San Francisco,<br />
6 Department of Physiopathology, University of Siena<br />
156. Ethanol induced dopamine release in the rat mesolimbic system. Role of<br />
acethaldehyde<br />
Sirca Donatella 1 , Mereu M. 1 , Golosio A. 1 , Enrico Paolo 2 , Diana M. 1<br />
1) “G. Minar<strong>di</strong>” Laboratory of Cognitive Neuroscience, Department of Drug Sciences;<br />
2) Department of Biome<strong>di</strong>cal Sciences. University of Sassari, 07100 Sassari, Italy<br />
157. RITIRATO<br />
pag_dx.indd 1 30/05/2007 5.49.12
158. Intermittent intoxication with ethanol vapor induces a long-lasting hypnotic<br />
tolerance and behavioral sensitivity in rat<br />
Rimon<strong>di</strong>ni R. † , Sommer W.*, Heilig M.*, Dall’Olio R. † , Locchi F. † , Gandolfi O †<br />
*Laboratory of Clinical and Translational <strong>Stu<strong>di</strong></strong>es, National Institute on Alcohol Abuse and<br />
Alcoholism, National Institutes of Health, Bethesda, MD 20892;<br />
† Department of<br />
Pharmacology, University of Bologna, 40128 Bologna, Italy<br />
159. Reduction of ethanol drinking following chronic administration of the antiepileptic<br />
levetiracetam in genetically selected alcohol preferring rats<br />
Stopponi Serena, Postolache Cristita, Nazzareno C., Economidou D., Fedeli A., Massi M.,<br />
Ciccocioppo R.<br />
University of Camerino, Italy<br />
160. Effect of the selective fatty acid amide hydrolase inhibitor URB597 on ethanol abuse<br />
related behaviours in the rat<br />
Braconi Simone, Piomelli D.*, Duranti A. § , Tonini A. § , Tarzia G. § , Cannella N., Massi M.,<br />
Ciccocioppo R., Cippitelli A.<br />
Department of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy;<br />
*Gillespie Neuroscience Facility, University of California, Irvine, USA; § Institute of Me<strong>di</strong>cinal<br />
Chemistry, University of Urbino “ Carlo Bò”, Italy<br />
132<br />
161. Neuropeptide S: a new neurotrasmitter system involved in relapse to alcoholseeking<br />
behaviour<br />
1 Cannella Nazzareno, 1 Economidou D., 1 Kallupi M., 2 Guerrini R., 3 Calò G., 1 Ciccocioppo R.<br />
1 Dept. of Experimental Me<strong>di</strong>cine and Public Health, University of Camerino, Italy; 2 Dept of<br />
Pharmaceutical Science and, 2 Dept. of Pharmacology, University of Ferrara, Italy<br />
Farmacologia della funzione respiratoria<br />
Poster 162 – 172<br />
162. Role of TGF- on MAP kinase phosphorylation and cell proliferation in primary<br />
cultures of human lung fibroblast<br />
Sullo Nikol, Gallelli L., De Nardo M., Orlotti D., Russo M., Marrocco G., D’Agostino B., De Sarro<br />
GB., Rossi F.<br />
Department of Experimental Me<strong>di</strong>cine, Sect. of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />
Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy.<br />
163. Ethanol sensitises TRPV1-me<strong>di</strong>ated cough in guinea pigs by a protein kinase C-<br />
dependent pathway<br />
Gatti Raffaele 1 , Andre E. 1 , Campi B. 1 , Geppetti P. 1, 2 Trevisani M. 1<br />
1 Inter<strong>di</strong>sciplinary Centre of Excellence for the Study of Inflammation (ICSI), University of<br />
Ferrara, Ferrara, Italy; 2 Department of Critical Care Me<strong>di</strong>cine and Surgery, University of<br />
Florence, Florence, Italy<br />
164. The role of ceramide pathway in asthma<br />
Giannini Lucia a , Bani D. b , Uliva C. a , Marzocca C. a , Comhair Suzy A.A. c , Erzurum Serpil C. c , Li<br />
D. d , Ndengele Michael d , Salvemini D. d , Masini E. a<br />
a Department of Preclinical and Clinical Pharmacology, and b Anatomy, Histology and Forensic<br />
Science, Section of Histology, University of Florence, Italy; c Pulmonary, Critical Care Me<strong>di</strong>cine<br />
and Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation,<br />
Cleveland, USA; d Internal Me<strong>di</strong>cine, Division of Pulmonary, Critical Care and Sleep Me<strong>di</strong>cine,<br />
St Louis University, St Louis, USA<br />
pag_sx.indd 1 30/05/2007 5.50.01
165. Role of nociceptin and its receptor in animal model of asthma<br />
Orlotti Donatella, De Nardo M., Russo M., Sullo N., Marrocco G., Rossi F., D’Agostino B.<br />
Department of Experimental Me<strong>di</strong>cine, Sect. of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />
Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy<br />
166. Activation of protease-activated receptor-2 reduces airways inflammation in<br />
experimental allergic asthma<br />
Russo Mariangela, Orlotti D., De Nardo M., Marrocco G., Sullo N., Guastafierro MG., Rossi F.,<br />
D’Agostino B.<br />
Department of Experimental Me<strong>di</strong>cine, Sect. of Pharmacology, Faculty of Me<strong>di</strong>cine and<br />
Surgery, 2nd University of Naples, via Constantinopoli 16, 80138 Naples, Italy<br />
167. M 3 muscarinic receptors in peripheral lung parenchima of patients with chronic<br />
obstructive pulmonary <strong>di</strong>sease<br />
Vincenzi F. 1 , Varani K. 1 , Caramori G. 2 , Tosi A. 1 , Gessi S. 1 , Merighi S. 1 , Fogli E. 1 , Sacchetto V.<br />
1 , Simioni C. 1 , Papi A. 2 , Borea P.A. 1<br />
Department of Clinical and Experimental Me<strong>di</strong>cine, Pharmacology Section 1 and Respiratory<br />
Disease Section 2 , University of Ferrara, Italy<br />
168. Glycogen synthase kinase-3 inhibition attenuates the development of bleomycininduced<br />
lung injury<br />
1,2 Cuzzocrea S., 1,2 Genovese T., 1,2 Mazzon E., 3 Esposito E., 1 Muià C., 4 Abdelrahman M., 1,2 Di<br />
Paola R., 2 Bramanti P., 4 Thiemermann C.<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />
University of Messina, Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy;<br />
3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”, Italy; 4 The<br />
William Harvey Research Institute, Centre for Experimental Me<strong>di</strong>cine, Nephrology and Critical<br />
Care, St Bartholomew’s and The Royal London School of Me<strong>di</strong>cine and Dentistry, London, UK<br />
133<br />
169. Modulation of the non-adrenergic, non-cholinergic inhibitory system by adenosine<br />
A 1 and A 3 receptors in the guinea-pig isolated trachea<br />
Dellabianca Antonio*, De Amici E.*, Tonini S.*, De Angelis S.**, Faniglione M.**, Candura S.<br />
M*, Tonini M.**<br />
*Dept. Preventive Occupational and Community Me<strong>di</strong>cine, University of Pavia; **Dept. of<br />
Physiological and Pharmacological Sciences, University of Pavia<br />
170. New roles for cysteinyl leukotriene in asthma: from airway remodelling to 2 -<br />
Adrenoreceptor dysfunction<br />
Rovati G. Enrico 1 , 2 Baroffio M. 1 Citro S., 1 Capra V., 2 Crimi C., 2 Brusisco V.<br />
1 Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Dept. of<br />
Pharmacological Sciences, University of Milan; and 2 Respiratory Pathophysiology Unit, Dept.<br />
of Internal Me<strong>di</strong>cine, University of Genoa<br />
171. Sphingosine-1-phosphate/Sphingosine kinase pathway is involved in mouse airway<br />
hyper-responsiveness<br />
Roviezzo Fiorentina, Di Lorenzo A., Bucci M., Brancaleone V., De Gruttola L., Vellecco V.,<br />
Rossi F., D’Agostino B., Cirino G.<br />
Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples-<br />
Federico II-; Department of Experimental Me<strong>di</strong>cine-Section of Pharmacology, Faculty of<br />
Me<strong>di</strong>cine and Surgery, 2nd University of Naples<br />
pag_dx.indd 1 30/05/2007 5.50.41
172. Evidence for a role of adenosine A1 receptor in bronchial hyperreactivity of<br />
sensitized wistar rats<br />
Alfieri Alessio, Cicala C.<br />
Department of Experimental Pharmacology, University of Naples “Federico II”, Naples<br />
Farmacologia dell'apparato <strong>di</strong>gerente<br />
Poster 173 – 184<br />
173. APP, a novel selective adenosine deaminase inhibitor, is effective against<br />
experimental colitis<br />
Antonioli Luca 1 , Fornai M. 1 , Colucci R. 1 , Ghisu N. 1 , Da Settimo F. 2 , Natale G. 3 , Vir<strong>di</strong>s A. 4 ,<br />
Breschi M.C. 5 , Del Tacca M. 1 , Blan<strong>di</strong>zzi C. 1<br />
1 Division of Pharmacology and Chemotherapy,<br />
1,4 Department of Internal Me<strong>di</strong>cine,<br />
2 Department of Pharmaceutical Sciences, 3 Department of Human Morphology and Applied<br />
Biology, and 5 Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology,<br />
University of Pisa, Pisa, Italy<br />
174. Effects of the non-peptidyl low molecular weight ra<strong>di</strong>cal scavenger IAC in DNBSinduced<br />
colitis in rats<br />
Vasina Valentina * , Broccoli M. * , Ursino M. G. * , Soleti A. # , Paolini M. * , De Ponti F. *<br />
* Department of Pharmacology, Alma Mater <strong>Stu<strong>di</strong></strong>orum - University of Bologna, Italy;<br />
# Medestea Research, <strong>Torino</strong>, Italy<br />
134<br />
175. The NK 1 receptor antagonist SSR140333 ameliorates experimental colitis in rats<br />
Ursino Maria Grazia, Vasina V., Croci Tiziano*, De Ponti F.<br />
Dept. of Pharmacology, University of Bologna, Bologna, Italy *Sanofi-Aventis Research<br />
Centre, Milan, Italy<br />
176. Responsiveness of longitu<strong>di</strong>nal and circular muscle to relaxing me<strong>di</strong>ators is<br />
<strong>di</strong>fferentially affected in rat hypertrophied ileum<br />
Bertoni Simona, Ghizzar<strong>di</strong> P., Tognolini M., Ballabeni V., Impicciatore M., Barocelli E.<br />
Dipartimento <strong>di</strong> Scienze Farmacologiche, Biologiche e Chimiche Applicate. Università <strong>degli</strong><br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> Parma. Viale Usberti 27/a, 43100 Parma, Italy<br />
177. In rat ileum adenosine deaminase is not only an ecto- but also an exo-enzyme<br />
Calligaro Giulia, Bin A., Giron M. C., Gaion R.M.<br />
Department of Pharmacology and Anesthesiology, University of Padova<br />
178. Herpes simplex virus-1 infection alters the carbachol- and KCl-induced contractions<br />
in rat small intestine<br />
Zoppellaro Chiara 1 , Brun P. 2 , Giron M. C. 1 , Bin A. 1 , Gaion R.M. 1 , Castagliuolo I. 2<br />
1 Department of Pharmacology and Anesthesiology, University of Padova; 2 Department of<br />
Histology, Microbiology & Me<strong>di</strong>cal Biotechnologies, University of Padova<br />
179. Adenosine receptors and metabolism in the intestinal tract<br />
Bin Anna 1 , Giron M.C. 1 , Calligaro G. 1 , Castagliuolo I. 2 , Gaion R.M. 1<br />
1 Department of Pharmacology and Anesthesiology, University of Padova<br />
2 Department of Histology, Microbiology and Me<strong>di</strong>cal Biotechnology, University of Padova<br />
180. Role of A 2A adenosine receptors in the regulation of human colon motility<br />
Fornai Matteo 1 , Antonioli L. 1 , Colucci R. 1 , Ghisu N. 1 , Buccianti P. 2 , Chiarugi M. 2 , Blan<strong>di</strong>zzi C. 1 ,<br />
Del Tacca M. 1<br />
1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, and<br />
2 Department of Surgery, University of Pisa, Pisa, Italy<br />
pag_sx.indd 1 30/05/2007 5.51.59
181. Gender-related role of nitric oxide in electrically evoked contractions in human<br />
colonic circular muscle<br />
Maselli M.A., Trisolini P., Pezzolla F., Demma I., De Ponti F.°<br />
Scientific Institute of Gastroenterology “S. de Bellis”, Castellana Grotte, Bari; °Department of<br />
Pharmacology, University of Bologna, Bologna, Italy<br />
182. Role of 5-HT receptors in modulating propulsive activity and accommodation in the<br />
guinea pig <strong>di</strong>stal colon<br />
Balestra Barbara*, Cervio E.*, Sternini C.**, De Giorgio R. # , Tonini M.*<br />
*Dept. of Physiological & Pharmacological Sciences, University of Pavia, **Dept. of Me<strong>di</strong>cine<br />
and Neurobiology, David Geffen School of Me<strong>di</strong>cine, University of California, Los Angeles,<br />
# Dept. of Internal Me<strong>di</strong>cine & Gastroenterology, University of Bologna, Italy<br />
183. The effects of UFP112, a novel nociceptin/orphanin FQ-NOP receptor ligand, on<br />
colonic propulsion and defecation in physiological and pathological con<strong>di</strong>tions<br />
Broccardo M. a , Agostini S. a , Guerrini R. b , Improta G. a , Linari G. a , Petrella C. a<br />
a Dept. Human Physiology and Pharmacology, University of Rome “Sapienza”, b Dept.<br />
Pharmaceutical Sciences and Biotechnology Center, University of Ferrara, Italy<br />
184. Effect of modeled microgravity con<strong>di</strong>tions on rat intestinal transit<br />
Peana Alessandra T. 1 ., Marzocco S. 2 , Pulighe E. 1 , Bianco G. 2 , Proto Pippia 1 , Pinto A. 2 ,<br />
Autore G. 2<br />
1 Department of Drug Science, University of Sassari, via Muroni 23/a, 07100, Sassari;<br />
2 Department of Pharmaceutical Science, University of Salerno, via Ponte don Melillo, 84084,<br />
Fisciano, Salerno<br />
Farmacologia del metabolismo e del sistema endocrino<br />
Poster 185 – 193<br />
135<br />
185. Menopausal transition: a possible risk factor for neurodegenerative events<br />
Rigamonti Antonello E. 1 , Bonomo S. M. 1 , Giunta M. 1 , Galimberti D. 2 , Guaita A. 3 , Gagliano M.<br />
G. 4 , Müller E. E. 1 , Cella S.G. 1<br />
1 Department of Me<strong>di</strong>cal Pharmacology and 2 Department of Neurological Sciences, Fondazione<br />
IRCCS Ospedale Maggiore Policlinico, Milan, Italy; 3 Geriatric Institute “Camillo Golgi”,<br />
Abbiategrasso, Italy; 4 Department of Transfusion Me<strong>di</strong>cine, “San Carlo Borromeo” Hospital,<br />
Milan, and CEND, University of Milan<br />
186. Effects of the phytoestrogen genistein on some pre<strong>di</strong>ctors of car<strong>di</strong>ovascular risk in<br />
osteopenic, postmenopausal women: a randomized, double-blind, placebocontrolled<br />
study<br />
Marini Herbert 1 , Minutoli L. 2 , Polito F. 2 , Bitto A. 2 , Altavilla D. 2 , Frisina N. 3 , D’Anna R. 4 , Lubrano<br />
C. 5 , Adamo E. B 1 , Caputi A. P. 2 ,Squadrito F. 2<br />
1 Dept. of Bioch., Phys. and Nutr. Sci., 2 Dept. of Clin. and Exp. Med. and Pharm., 3 Dept. of Int.<br />
Med., 4 Dept. of Obst. and Gyn. Sci., Messina; 5 Dept. of Med. Physiop., “La Sapienza” Univ.,<br />
Rome, Italy<br />
187. In vitro and in vivo anti-inflammatory activities of pseudomorelin, a ghrelin-mimetic<br />
pseudotetrapeptide<br />
Ghè Corrado, Baragli A., Arnoletti E., Deghenghi R., Muccioli G.<br />
Division of Pharmacology, Department of Anatomy, Pharmacology and Forensic Me<strong>di</strong>cine,<br />
University of Turin, Turin, Italy<br />
pag_dx.indd 1 30/05/2007 5.52.47
188. Ghrelin and des-acyl ghrelin induce murine C2C12 myoblasts <strong>di</strong>fferentiation and<br />
fusion into myotubes<br />
Arnoletti Elisa § , Filigheddu N.*, Ghè C. § , Ponzetto C. ‡ , Crepal<strong>di</strong> T. ‡ , Graziani A.*, Muccioli G. §<br />
§ Division of Pharmacology and ‡ Anatomy, Department of Anatomy, Pharmacology and<br />
Forensic Me<strong>di</strong>cine, University of Turin, Turin, Italy; *Department of Me<strong>di</strong>cal Sciences,<br />
University of Piemonte Orientale “Amedeo Avogadro”, Novara, Italy<br />
189. Endocrine and extraendocrine effects of ghrelin and novel synthetic analogs<br />
Bulgarelli Ilaria a , Bresciani E. a , Tamiazzo L. a , Rapetti D. a , Perrissoud D. b , Torsello A. a,c ,<br />
Locatelli V. a,c<br />
a Department of Experimental Me<strong>di</strong>cine, University of Milan Bicocca, Monza, Italy; b Zentaris<br />
GmbH, Frankfurt, Germany; c Interdepartmental Center for Bioinformatics and Proteomics,<br />
University of Milano-Bicocca, Monza, Italy<br />
190. Efects of irbesartan on the myocar<strong>di</strong>al ischemia/reperfusion injury in ZDF rats with<br />
metabolic syndrome<br />
Di Filippo Clara 1,2 , Lampa E. 1,2 , Martella R. 3 , Vargiu G. 4 , Paizis G. 4 , D’Amico M. 1,2<br />
1 Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology L. Donatelli, 2 ”Excellence<br />
Centre for Car<strong>di</strong>ovascular Disease”, and 3 Department of Geriatrics and Metabolic Diseases,<br />
2nd University of Naples, Italy. 4 Sanofi-Aventis, Milano<br />
136<br />
191. Effects of liposome-encapsulated pyrazolo-pyrimi<strong>di</strong>ne derivate on the growth of<br />
human thyroid cancer cells<br />
1 Celano Marilena, 1 Cosco D., 2 Navarra M., 1 Alcaro S., 3 Schenone S., 1 Procopio S., 1 Varano E.,<br />
4 Botta M., 1 Fresta M., 1 Russo D.<br />
1 Dip. <strong>di</strong> Scienze Farmacobiologiche Univ. Catanzaro, 2 Dip. Farmacobiologico, Univ. Messina,<br />
3 Dip. Scienze Farmaceutiche, Univ. Genova, e 4 Dip. Farmaco Chim. Tecnol., Univ. Siena<br />
192. Effect of testosterone on p70S6k phosphorylation in skeletal muscle cell coltures<br />
1 Dattolo Maria G., 1 Saviano R., 1 La Rana G., 1 Calignano A., 2 Miniaci M. , 1 Scotto P.<br />
1 Dept.of Experimental Pharmacology, University of Napoli “Federico II”; 2 Dept.of Experimental<br />
and Clinical Me<strong>di</strong>cine, University of Catanzaro, Italy<br />
193. Endogenous benzo<strong>di</strong>azepines and intestinal bacterial flora in normal and<br />
pathological con<strong>di</strong>tions<br />
Campioli Enrico § , Avallone R. § , Ferrieri A. § , Baral<strong>di</strong> M. §°<br />
§ Department of Biome<strong>di</strong>cal Sciences, Via Campi 287, 41100 Modena, Italy, °National<br />
InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN),<br />
Farmacologia dell'infiammazione<br />
Poster 194 – 204<br />
194. Effects of a methanolic extract of sedum telephium in LPS-activated rat<br />
macrophages<br />
Polito Francesca 1 , Bitto A. 1 , Minutoli L. 1 , Fiumara T. 1 , Giachetti D. 2 , Miral<strong>di</strong> E. 2 , Biagi M. 2<br />
Squadrito F. 1 , Caputi A. P. 1 , Altavilla D. 1<br />
1 Dept of Exp and Clinical Me<strong>di</strong>cine and Pharmacology and 2 Dept of Environmental Sci, Section<br />
of Pharm Biol, University of Siena, Italy<br />
195. Different phenotypes of microglia activation<br />
Dello Russo Cinzia, Tringali G., Navarra P.<br />
Istituto <strong>di</strong> Farmacologia, Università Cattolica del S Cuore, Largo F Vito 1 - Roma<br />
pag_sx.indd 1 30/05/2007 5.53.35
196. Mapping of the human promoter of GNB2L1 gene enco<strong>di</strong>ng the RACK1 protein and<br />
its regulatory role in the immunosenescence<br />
Del Vecchio Igor 1 , Zuccotti A. 1 , Corsini E. 2 , Racchi M. 1 , Lucchelli A. 1 , Govoni S. 1<br />
1 Department of Experimental and Applied Pharmacology, University of Pavia, Viale Taramelli<br />
14, 27100 Pavia, Italy; 2 Department of Pharmacological Sciences, University of Milano, Via<br />
Balzaretti 9, 20133 Milan, Italy<br />
197. Antinflammatory activity and gastroprotective effect of the antioxidant compound<br />
iacvita in rats<br />
Zavatti Manuela, Zanoli P., Montanari C., Vezzalini F. , Baral<strong>di</strong> M.<br />
Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology and National InterUniversity<br />
Consortium for the Study of Natural Active Principles (CINSPAN), University of Modena and<br />
Reggio Emilia, Modena, Italy<br />
198. The glucocorticoid-induced leucine zipper (GILZ) protects against DNBS-induced<br />
colitis development<br />
Velar<strong>di</strong> Enrico 1 , Donato V. 1 , Bruscoli S. 1 , Mazzon E. 2 , Cannarile L. 1 , Cuzzocrea S. 2 , Riccar<strong>di</strong><br />
C. 1<br />
1 Dept. Clinical and Experimental Me<strong>di</strong>cine, Sect. Pharmacology, Perugia University Me<strong>di</strong>cal<br />
School, 06122, Perugia, and 2 Dept Clinical and Experimental Me<strong>di</strong>cine and Pharmacology,<br />
Messina University Me<strong>di</strong>cine School, Torre Biologica, Policlinico Universitario, 98123, Italy<br />
199. Mucin depleted foci (MDF) are useful biomarkers to study inflammation-induced<br />
colon carcinogenesis in rodents<br />
Caderni Giovanna, Femia A.P., Dolara P., Tarquini E., Salvadori M.<br />
Department of Pharmacology University of Florence, Florence, Italy<br />
137<br />
200. Local administration of palmitoylethanolamide reduces chronic granulomaassociated<br />
angiogenesis in rat<br />
D’Amico Alessandra, De Filippis D., Iuvone T.<br />
1 Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples<br />
Federico II, Via D. Montesano 49, 80131 Naples, Italy<br />
201. Contribution of 4 1 integrin to the antiallergic effect of levocabastine in<br />
experimental conjunctivitis<br />
Spartà Antonino M., Qasem Ahmed R., Bucolo C., Baiula M., Govoni P., Fascì D., Spampinato<br />
S.<br />
Department of Pharmacology, University of Bologna<br />
202. Protection against UVB-induced damage in rabbit eye by 4-coumaric acid<br />
Lodovici Maura 1 , Morbidelli L. 2 , Akpan V. 1 , Ziche M. 2 , Dolara P. 1<br />
1 Department of Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence<br />
(Italy); 2 Department of Molecular Biology, University of Siena, Via A. Moro 2, 53100 Siena<br />
(Italy)<br />
203. CT327, a novel therapeutic agent for topical treatment of psoriasis<br />
Barone Domenico, Bertarione Rava Rossa L., Traversa S., Mainero V., Oderda C., Pincelli C.*,<br />
Marconi A.*, Fumero S.<br />
Creabilis therapeutics SpA, Via Ribes, 5 – 10010 Colleretto Giacosa (TO), Italy; *University of<br />
Modena e Reggio Emilia, Via del Pozzo, 71 – 41100 Modena, Italy<br />
pag_dx.indd 1 30/05/2007 5.54.15
204. Role of peroxisome proliferators activated receptors alpha (PPAR-) in acute<br />
pancreatitis induced by cerulean<br />
1 De Sarro Angelina, 1,2 Mazzon E., 1,2 Genovese T., 1,2 Di Paola R., 1 Muià C., 1 Malleo G.,<br />
3‡ Esposito E., Caputi A.P. 1,2 ., Cuzzocrea S. 1,2<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />
University of Messina, Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy;<br />
3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”, Napoli, Italy<br />
Chemioterapia antibatterica, antivirale e antineoplastica<br />
Poster 21 – 30<br />
205. Analysis of the thymidylate synthase gene structure in colorectal cancer patients,<br />
and its possible relation with the 5-fluorouracil drug response<br />
Sanguedolce Rosario 1 , Gulotta G. 2 , Cajozzo M. 3 , Agrusa A. 2 , Feo S. 4 , Sanguedolce G. 1 ,<br />
Calascibetta A. 1<br />
1 Dipartimento <strong>di</strong> Scienze Farmacologiche, 2 Chirurgia Generale e d’Urgenza, 3 Dipartimento <strong>di</strong><br />
Discipline Chirurgiche ed Oncologiche, 4 DOSAC. University of <strong>Stu<strong>di</strong></strong>es of Palermo<br />
138<br />
206. Irinotecan metronomic chemotherapy in metastatic colorectal cancer patients: a<br />
pharmacokinetic and pharmacodynamic study<br />
Bocci Guido 1 , Allegrini G. 2 , Fioravanti A. 1 , Orlan<strong>di</strong> P. 1 , Loupakis Fotios 2 , Barletta M. T. 2 , Di<br />
Paolo A. 1 , Falcone A. 2 , Danesi R. 1 , Del Tacca M. 1<br />
1 Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />
Pisa, Pisa; 2 Division of Me<strong>di</strong>cal Oncology, General Hospital, Livorno<br />
207. Adenosine receptor A3: role and expression in human thyroid cancer<br />
Pinto A., Morello S., Petrella A., Festa M., Popolo A., Parente L., Chiappetta G.*<br />
Department of Pharmaceutical Sciences, University of Salerno, Italy; *Tumor Institute,<br />
Fondazione Senatore G. Pascale, Naples, Italy<br />
208. Antimetastatic effect of a novel non competitive CXCR1/CXCR2 inhibitor in human<br />
melanoma<br />
*Bruno Annalisa, *Mosca M., *Buanne P., °Del Bufalo D., °Desideri M., °Giorgini S., § Ruco L.,<br />
*Allegretti M., *Gloaguen I., *Bizzarri C., * Melillo G., *Bertini R., °Zupi G.<br />
*Dompé pha.r.ma s.p.a., via Campo <strong>di</strong> Pile, 67100 L’AQUILA, ITALY; °Regina Elena Cancer<br />
Institute, via delle Messi d’Oro 156, 00158 ROME, ITALY; § S.Andrea Hospital, University La<br />
Sapienza, via <strong>di</strong> Grottarossa 1035, 00189 ROME, ITALY<br />
209. Pharmacokinetics of cisplatin during intraperitoneal hyperthermic chemotherapy<br />
perfusion (IHCP) in patients with peritoneal carcinomatosis<br />
*Cerretani Daniela, *Ferraro M. T., *Fiaschi A. I., *Miceli G. B.,**Cioppa T., **Marrelli<br />
D.,**Corso G.,**Pedrazzani C.,**Roviello F.<br />
*Department of Pharmacology “G. Segre”, University of Siena; **Department of Human<br />
Patology and Oncology, Unit of Surgical Oncolgy, University of Siena<br />
210. Effects of zoledronic acid on cathepsin K circulating levels in patients with bone<br />
metastasis<br />
Leto Gaetano¹, Tumminello F.M¹., Badalamenti G.², Incorvaia L.², Fulfaro F.², Crescimanno<br />
M.¹, Flan<strong>di</strong>na C.¹, Gebbia N.²<br />
¹Lab. Chemioter. Sperimentale and ²U.O. <strong>di</strong> Oncologia Me<strong>di</strong>ca, Dipartimento <strong>di</strong> Discipline<br />
Chirurgiche ed Oncologiche; Policlinico Universitario P. Giaccone, 90127 Palermo, Italy<br />
pag_sx.indd 1 30/05/2007 5.55.11
211. Therapeutic drug monitoring of antiretroviral agents: determination of plasma<br />
concentrations by means of a high-pressure liquid chromatographic technique<br />
Pinetti Diego i , Motta A. ii , Gallesi D. i , Guaral<strong>di</strong> G. ii<br />
i Toxicology and Clinical Pharmacology, Department of Laboratory Services, University of<br />
Modena and Reggio Emilia; ii Department of Me<strong>di</strong>cine and Me<strong>di</strong>cine Specialities, University of<br />
Modena and Reggio Emilia<br />
212. H 2 S and no affect intracellular killing of can<strong>di</strong>da albicans modulating GSH levels<br />
Grosso Silvia 1 , Caronno A. 1 , Lucini V. 1 , Pannacci M. 1 , Sullo N. 2 , Scaglione F. 1<br />
1 Department of Pharmacology, University of Milan, Milan, Italy; 2 Depatment of Experimental<br />
Me<strong>di</strong>cine- Section of Pharmacology, II University of Naples, Naples, Italy<br />
213. Pharmacokinetic/pharmacodynamic of macrolides in an in vivo model of Chlamy<strong>di</strong>a<br />
pneumoniae's pneumonia<br />
Caronno Alessia, Lucini V., Grosso S., Pannacci M., Scaglione F.<br />
Department of Pharmacology, University of Milan, Milan, Italy<br />
214. Bioavailability improvement of polymyxin B by calcium alginate/chitosan<br />
microparticles<br />
Rossi Tiziana°, Baggio G.°, Coppi A.°, Bruni E.°, Ruberto A.°, Iannuccelli V.* Coppi G.*<br />
University of Modena and Reggio Emilia- Italy: °Department of Biome<strong>di</strong>cal Sciences- Section<br />
of Pharmacology; * Department of Pharmaceutical Sciences, 287 G. Campi st 41100 Modena<br />
Italy<br />
Immunofarmacologia<br />
Poster 215 – 224<br />
139<br />
215. Atorvastatin treatment influences polymorphonuclear leukocyte function: a<br />
longitu<strong>di</strong>nal study<br />
Loraschi Anna, Schembri L., Maio R.C., Marino F., Cosentino M., Guasti L., Rasini E., Legnaro<br />
M., Colombo C., Cereda E., Cimpanelli M., Castiglioni L., Tozzi M.*, Castelli P.*, Venco A.,<br />
Lecchini S.<br />
Department of Clinical Me<strong>di</strong>cine, Section of Experimental and Clinical Pharmacology and<br />
*Department of Surgical Surgical Science, University of Insubria, Varese, Italy<br />
216. Treatment with simvastatin mo<strong>di</strong>fies AT 1 R expression and function in<br />
polymorphonuclear leukocyte of high car<strong>di</strong>ovascular risk subjects: a longitu<strong>di</strong>nal<br />
study<br />
Maio Ramona Consuelo, Marino F., Guasti L., Cosentino M., Rasini E., Ferrari M., Cimpanelli<br />
M.G., Loraschi A., Legnaro M., Cereda E., Crespi C., Venco A., Lecchini S.<br />
Department of Clinical Me<strong>di</strong>cine, Section of Experimental and Clinical Pharmacology,<br />
University of Insubria, Varese<br />
217. Effects of atorvastatin treatment on the modulation of leukocyte function in patients<br />
undergoing peripheral vascular intervention: a longitu<strong>di</strong>nal study<br />
Schembri Laura, Loraschi A., Maio R.C., Marino F., Cosentino M., Guasti L., Rasini E., Legnaro<br />
M., Colombo C., Cereda E., Cimpanelli M., Castiglioni L., Tozzi M. 1 , Castelli P. 1 , Venco A.,<br />
Lecchini S.<br />
Department of Clinical Me<strong>di</strong>cine, Section of Experimental and Clinical Pharmacology and<br />
1 Department of Surgical Sciences, University of Insubria, Varese, Italy<br />
pag_dx.indd 1 30/05/2007 5.55.49
218. Atorvastatin and minocycline, effective combination in experimental autoimmune<br />
encephalomyelitis<br />
Luccarini Ilaria a , Biagioli T. b , Ballerini C. b , Biamonte F. c , Bellucci A. d , Fiorentini A. a , Casamenti<br />
F. a<br />
a Dept of Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. b Dept<br />
of Neurology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy. c Dept of<br />
Neuroscience, University Campus Bio-Me<strong>di</strong>co of Rome, Italy. d Dept Biomed. and Biotechnol.<br />
Sci., University of Brescia, Viale Europa 11, 25123 Brescia, Italy.<br />
219. IL-2 induces an altered CD4/CD8 ratio of splenic T lymphocytes from transgenic<br />
mice overexpressing the glucocorticoid-induced protein GILZ<br />
Pozzesi Nicola, Riccar<strong>di</strong> C., Delfino D.V.<br />
Section of Pharmacology, Toxicology and Chemotherapy, Department of Clinical and<br />
Experimental Me<strong>di</strong>cine, University of Perugia Me<strong>di</strong>cal School, Perugia, Italy<br />
220. Out of frame BCR-ABL fusion peptides as targets of the immunotherapy in chronic<br />
myelogenous leukemia<br />
Casnici Clau<strong>di</strong>a, Crotta K., Lattuada D., Mastrotto C., Volpe G. * , Panuzzo C.*, Kuka M.*,<br />
Saglio G.*, Marelli O.<br />
Department of Pharmacology, School of Me<strong>di</strong>cine, University of Milan, Milan, Italy;<br />
*Department of Clinical and Biological Science, University of Turin, Turin, Italy<br />
140<br />
221. Expression of the ang II type 1 receptor on human CD4 + CD25 +hi regulatory T cells<br />
Rasini Emanuela, Marino F., Guasti L., Ferrari M., Legnaro M. Schembri L., Venco A., Lecchini<br />
S., Cosentino M.<br />
Department of Clinical Me<strong>di</strong>cine, University of Insubria, Varese, Italy<br />
222. Effect of <strong>di</strong>fferent mentha piperita varieties on proliferation and cytokine production<br />
in human peripheral blood mononuclear cells<br />
Carcano Elena, Cosentino M., Bombelli R., Luini A., Marino F., * Colombo M. L., # Conti A.,<br />
Lecchini S.<br />
Dept. Clinical Me<strong>di</strong>cine, Sect. Clin. Exp. Pharmacology, University of Insubria, Varese, I,<br />
* Dept. Pharm. Sci. Technol., University of Turin, I, and # Alpine Foundation for Life Sciences,<br />
Olivone, CH<br />
223. Mo<strong>di</strong>fied -galactosyl ceramide analogs for stimulating iNKT cells: a<br />
pharmacological characterization<br />
Fallarini Silvia 1 , Panza L. 1 , Compostella F. 2 , Ronchetti F. 2 , De Libero G. 3 , Lombar<strong>di</strong> G. 1<br />
1 DISCAFF Department, University of “Piemonte Orientale”, Novara, Italy ; 2 Department of<br />
Chemistry, Biochemistry and Biotechnology for Me<strong>di</strong>cine, University of Milano, Milano, Italy;<br />
3 Experimental Immunology, Department of Research, University Hospital, Basel, Switzerland<br />
224. A tuscan olive oil extract inhibits Nuclear Factor-Kappa B activation in<br />
monocyte/macrophages from healthy donors<br />
Bardelli Clau<strong>di</strong>o 1 , Gunella G. 1 , Amoruso A. 1 , Brunelleschi S. 1 , Romani A. 2 , Ieri F. 2 , Coinu R. 3 ,<br />
Franconi F. 3<br />
1 Dept. Me<strong>di</strong>cal Sciences, University “A. Avogadro”, Novara (Italy); 2 Dept. Pharmacological<br />
Chemistry, University of Florence (Italy);<br />
3 Center of Excellence for Biotechnology<br />
Development and Bio<strong>di</strong>versity Research, University of Sassari (Italy)<br />
pag_sx.indd 1 30/05/2007 5.56.38
Farmacologia clinica e sperimentazione clinica dei farmaci<br />
Poster 225 – 240<br />
225. Quality of life of pe<strong>di</strong>atric patients with attention deficit hyperactivity <strong>di</strong>sorder and<br />
oppositive defiant <strong>di</strong>sorder: an italian double-blind placebo-controlled study with<br />
atomoxetine<br />
Dell’Agnello Grazia 2 , Curatolo P. 1 , Mancini F. 2<br />
1 Neuropsychiatria Infantile Clinica Sant’Alessandro, Rome, Italy; 2 Eli Lilly Italia<br />
226. Evening and early morning administration of atomozetine in ADHD children: a<br />
comparison<br />
Dell’Agnello Grazia 4 , Kelsey D. 1 , Sutton V. 1 , Lewis D. 2 , Schuh K. 1 ; Sumner C. 1 , Quintana H. 3 ,<br />
Fre<strong>di</strong>ani S. 4 , Rossi A. 4<br />
1 Lilly Research Laboratories,In<strong>di</strong>anapolis,IN;<br />
2 Monarch Me<strong>di</strong>cal Research,Norfolk,VA;<br />
3 Louisiana State University Health Science Center,New Orleans,LA; 4 Eli Lilly Italia<br />
227. Safety and tolerability of duloxetine in the treatment of major depressive <strong>di</strong>sorder:<br />
analysis of pooled data from eight placebo-controlled clinical trials<br />
Mancini Michele, Barraco A., Rossi A.<br />
Eli Lilly Italia S.p.A.<br />
228. The new antidepressant duloxetine: car<strong>di</strong>ovascular effects<br />
Mancini Michele, Barraco A., Rossi A.<br />
Eli Lilly Italia S.p.A.<br />
229. The management of bipolar mania: a national survey of baseline data from the<br />
emblem study<br />
Mancini Michele 2 , Bellantuono C. 1 , Rossi A. 2 , Barraco A. 2 , Goetz I. 3 , for the Italian EMBLEM<br />
study group<br />
1 Department of Me<strong>di</strong>cine and Public Health, Section of Psychiatry and Clinical Psychology,<br />
University of Verona, Italy; 2 Eli Lilly Italia S.p.A. for the Italian EMBLEM study group; 3 Eli Lilly<br />
and Company, Windlesham, UK<br />
141<br />
230. European mania in bipolar longitu<strong>di</strong>nal evaluation of me<strong>di</strong>cation (emblem) study:<br />
results of the acute 12-week phase in Italy by regional location (north, centre and<br />
south)<br />
Mancini Michele 1 , Rossi A. 1 , Barraco A.1, Goetz I. 2 , for the Italian EMBLEM study group<br />
1 Eli Lilly Italia S.p.A.; 2 Eli Lilly and Company, Windlesham, UK<br />
231. Effectiveness of antipsychotic treatment in outpatients with schizophrenia: 36-<br />
month results from the schizophrenia outpatients health outcomes (SOHO) study<br />
Scatigna Marco (3) , Novick Diego (1) , Haro Josè M. (2) , Brown James (1) , Suarez Diego (2) , Rossi<br />
Andrea (3) , Fre<strong>di</strong>ani Sonia (3) , Ratcliffe Mark C. (1) , and the SOHO Study Group (4)<br />
(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca e sviluppo, San Joan de Deu-SSM,<br />
Sant Boi, Barcellona, Spagna (3) Eli illy Italia S.p.A. (4) Alonso J (SP), Gasquet I (FR), Haro JM<br />
(SP) Jones PB (UK), Knapp M (UK), Lepine JP (FR), Naber D (DE), Slooff CJ (NL)<br />
232. Tolerability of outpatient antipsychotic treatment: 36-month results from the<br />
european schizophrenia outpatients health outcomes (soho) study<br />
Scatigna Marco (5) , Novick D. (1) , Haro Josè M. (2) , Suarez D. (2) , Bushe C. (3) , Lepine A. (4) , Rossi<br />
A. (5) , Fre<strong>di</strong>ani S. (5) , the SOHO Study Group (6)<br />
(1) Eli Lilly and Company, Windlesham, UK (2) Unità ricerca e sviluppo, San Joan de Deu-SSM,<br />
Sant Boi, Barcellona, Spagna (3) Eli Lilly and Company, Basingstoke, UK; (4) Hôpital Fernand<br />
Widal Parigi Cedex 10 (5) Eli Lilly Italia S.p.A. (6) Alonso J (SP), Gasquet I (FR), Haro JM (SP)<br />
Jones PB (UK), Knapp M (UK), Lepine JP (FR), Naber D (DE), Slooff CJ (NL)<br />
pag_dx.indd 1 30/05/2007 5.57.26
233. Therapeutic monitoring of clozapine, ABCB1 genotyping and response to treatment<br />
in psychotic patients<br />
Lastella Marianna*, Consoli G.°, Amatori F.*, Catena M.°, Ciapparelli A.°, Ciofi L.*, Golia F.°,<br />
Carmassi C.°, Danesi R.*, Dell’Osso L.°, Del Tacca M.*, Di Paolo A.*<br />
*Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />
Pisa; °Psychiatric Clinic, Department of Psychiatry, Neurobiology, Pharmacology and<br />
Biotechnology, University of Pisa, Pisa<br />
234. Essential tremor is responsive to combined topiramate and declorazepam treatment<br />
Gallelli Luca 2 , Siniscalchi A. 1 , Borner Perrone I. 2 , Davoli A. 2 , De Sarro G. 2<br />
1 Department of Neuroscience, Neurology Division, “Annunziata” Hospital, Cosenza, Italy;<br />
2 Chair of Pharmacology, Department of Experimental and Clinical Me<strong>di</strong>cine, Faculty of<br />
Me<strong>di</strong>cine, University Magna Graecia of Catanzaro, Catanzaro, Italy<br />
235. Therapeutic drug monitoring of gentamicin in newborns: our experience<br />
Martinelli Valentina, Serpi A.*, Carta P., Fanos V.*, Del Zompo M., Testa M.*<br />
Section of Clinical Pharmacology, Department of Neurosciences “B.B. Bro<strong>di</strong>e”, University of<br />
Cagliari; *Institute of Neonatal Pathology and Intensive Therapy, University of Cagliari<br />
142<br />
236. Phase II marker lesion study of 6-week intravesical gemcitabine instillation in<br />
patients with low-risk superficial bladder cancer<br />
Russo Francesca 6 , Brausi M. 1 , Giussani L. 2 , Altieri V. 3 , Rigatti P. 4 , Gontero P. 5 , Bertelli L. 6 ,<br />
Rossi A. 6 , Langer F. 7 , Bono A. 2<br />
1 Divisione <strong>di</strong> Urologia AUSL, Modena, 2 Divisione <strong>di</strong> Urologia Ospedale <strong>di</strong> Circolo e Fondazione<br />
Macchi, Varese, 3 Clinica Urologia Azienda Universitaria Policlinico Federico II , Napoli,<br />
4 Clinica Urologia Università Vita e Salute, Ospedale S. Raffaele, Milano, 5 Clinica <strong>di</strong> Urologia<br />
Ospedale Maggiore della Carità, Novara, 6 Eli Lilly Italia; 7 Eli Lilly EuMed<br />
237. Comparison between <strong>di</strong>fferent topical hypotensive drugs in two experimental<br />
models of glaucoma in the rabbit<br />
*Fabrizi Francesca, °Giambene B., °Galassi G., *Uliva C., § Ongini E., *Masini E.<br />
*Department of Preclinical and Clinical Pharmacology; University of Florence;°Department of<br />
Oto-neuro-ophthalmological Sciences, University of Florence and § NicOx Research Institute,<br />
Milan, Italy<br />
238. Plasma levels of arginine and lactate in rehabilitation patients with spinal cord<br />
injury and pressure ulcers<br />
Verri Manuela*, Aquilani R.^, Boschi F.*, Dossena M.*, Iadarola P.°, Viglio S.°, Pastoris O.*<br />
*Department of Physiological & Pharmacological Sciences; °Department of Biochemistry “A.<br />
Castellani”, University of Pavia, Pavia, Italy; ^IRCCS “S. Maugeri” Foundation, Montescano,<br />
Italy<br />
239. Sildenafil citrare versus Tadalafil for ED treatment: preference of italian patients<br />
and reasons of their choice<br />
Gentilella Raffaella 6 , Fusco F., Lembo A. 1 , Ludovico G.M. 2 , Pirozzi Farina F. 3 , Montorsi F. 4 ,<br />
Menchini Fabris F. 5 , Sicuteri R. 6 , Rossi A. 6 , Mirone V.<br />
Clinica Urologica, Università Federico II, Napoli; 1 Div. Urologia, Ospedali Riuniti <strong>di</strong> Bergamo;<br />
2 Unità <strong>di</strong> Urologia Operativa, Ospedale Civile, Monopoli, Bari; 3 Università Di Sassari, Clinica<br />
Urologica; 4 Reparto <strong>di</strong> Urologia, Ospedale S. Raffaele, Milano; 5 Unità <strong>di</strong> Andrologia, Università<br />
<strong>di</strong> Pisa, Pisa; 6 Eli Lilly Italia<br />
240. The magnitude of inhibitory drug interactions is dependent on liver functional status<br />
Pegoraro Paola 1 , De Martin S. 1 , Orlando R. 2 , Palatini P. 1<br />
1 Department of Pharmacology and Anaesthesiology, and of 2 Me<strong>di</strong>cal and Surgical Sciences<br />
University of Padova, Italy<br />
pag_sx.indd 1 30/05/2007 5.58.25
Farmacovigilanza, farmacoepidemiologia e farmacoeconomia<br />
Poster 241 – 253<br />
241. Gabapentin-induced rhabdomyolysis: a case report<br />
Tuccori Marco 1,2 , Lombardo G. 2 , Lapi F. 1,4 , Vannacci A. 1,4 , Blan<strong>di</strong>zzi C. 1,4 , Mugelli A. 1,4 , Del<br />
Tacca M. 1,2<br />
1 Tuscan Regional Center for Pharmacovigilance;<br />
2 Division of Pharmacology and<br />
Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of Pisa – Pisa, Italy; 3 Intensive<br />
Care Unit - Hospital of Empoli, Florence – Italy; 4 Department of Preclinical and Clinical<br />
Pharmacology - University of Florence, Florence – Italy<br />
242. Anticoagulants and drugs at interaction risk<br />
Alacqua Marianna 1 , Trifirò G. 1,4 , Moretti S. 3 , Tari M. 3 , Galdo M. 3 , Tari U. 3 , Caputi A.P. 1,4 ,<br />
UVEC group 3 , ArcoracI V. 1<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, Pharmacology Unit,<br />
University of Messina, Italy - 2 Division of Child Neurology and Psychiatry, University of<br />
Messina, Italy - 3 “Caserta 1” Local Health Service, Caserta, Italy - 4 IRCCS Centro Neurolesi<br />
"Bonino-Pulejo", Messina, Italy<br />
243. Vigilance system for undesirable effects of cosmetic products (cosmetovigilance) in<br />
Europe<br />
Sportiello Liberata 1 , Sautebin L. 1,2<br />
1 Department of Experimental Pharmacology, 2 Pharmacoeconomic and Pharmacoutilization<br />
Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy<br />
244. Notification of undesirable effects of cosmetic products by pharmacists and<br />
dermatologists: a pilot project<br />
Sautebin Li<strong>di</strong>a<br />
Department of Experimental Pharmacology, Pharmacoeconomic and Pharmacoutilization<br />
Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy<br />
143<br />
245. Gender <strong>di</strong>fference in adverse drug reactions: analysis of spontaneous reports of an<br />
italian interregional database (GIF)<br />
Salvo F. (1) , Cutroneo P.M. (1) , Meneghelli I. (2) , Motola D. (3) , Del Tacca M. (4) , Ros B. (5) , Capuano<br />
A. (6) , Leoni O., Polimeri G. (1)<br />
(1) Dep. Clin Experim Med and Pharmacol, University of Messina, Italy - (2) Clinical<br />
Pharmacology Unit, University of Verona, Italy - (3) Interuniversity Research Centre for<br />
Pharmacoepidemiology, University of Bologna, Italy - (4) Division of Pharmacology and<br />
Chemotherapy, University of Pisa, Italy; (5) Pharmaceutical Service of Friuli Venezia Giulia<br />
Health Department, Trieste, Italy - (6) Department of Experimental Me<strong>di</strong>cine, Second University<br />
of Naples, Italy - (7) Lombardy Centre of Pharmacovigilance, Milan, Italy<br />
246. Gender and age-related drug prescription patterns in the varese local health<br />
authority<br />
Leoni Olivia 1 , Banfi F. 2 , Soma R. 1 , Manfre<strong>di</strong> L. 1 , Oria C. 1 , Roi C. 1<br />
1 PAC Department, Varese Local Health Authority, Italy; 2 Health Managed, Varese Local Health<br />
Authority, Italy<br />
247. The pharmacological consultation service as a valid tool for developing a correct<br />
drug approach: "the Poppers' case"<br />
Stochino M. Erminia, Asuni C., Carta P., Del Zompo M.<br />
Drug Information Centre, Section of Clinical Pharmacology, Department of Neurosciences<br />
“B.B. Bro<strong>di</strong>e”, University of Cagliari<br />
pag_dx.indd 1 30/05/2007 5.59.06
248. Adverse reactions to contrast me<strong>di</strong>a: an analysis from spontaneous reporting data<br />
Paola Cutroneo 1 , Polimeri G. 1,2 , Curcuruto R. 1 , Russo A. 1 , Calapai G. 1 , Caputi A.P. 1<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />
University of Messina, Italy; 2 Istituto <strong>di</strong> Ricovero e Cura a Carattere Scientifico (IRCCS)<br />
Centro Neurolesi "Bonino-Pulejo," Messina, Italy<br />
249. Regional surveillance of emergency department visits for outpatient adverse drug<br />
events<br />
Gallo Mariapina, Ferrante L., Illiano M.L., Russo F., Annibale R., Filippelli A., Rossi F.,<br />
Captano A.<br />
Department of Experimental Me<strong>di</strong>cine, Section of Pharmacology “Leonardo Donatelli”. Center<br />
of Pharmacosurveillance and Pharmacoepidemiology, Faculty of Me<strong>di</strong>cine and Surgery, Second<br />
University of Naples, Italy<br />
250. Pharmacovigilance teaching in the european faculties of pharmacy<br />
Rossi Antonietta 1 , Pergola C. 1 , Sautebin L. 1,2<br />
1 Department of Experimental Pharmacology, 2 Pharmacoeconomic and Pharmacoutilization<br />
Research Centre, Faculty of Pharmacy, University of Naples Federico II, Naples, Italy.<br />
144<br />
251. Promoting continuing education in pharmacovigilance: the experience of<br />
"Pharmasearch", a network of general practitioners reporting adverse drug<br />
reactions<br />
Catania Maria A. 1 , Salvo F. 1 , Oteri A. 1 , Polimeni G. 1,5 , Russo A. 1 , Giustini Saffi E. 2 , Sessa A. 2 ,<br />
Tuccori M. 3 , Martelli A. 4 , Del Tacca M. 3 , Caputi A. P. 1,5<br />
1 University of Messina; 2 Area Pharmasearch, SIMG;<br />
3 University of Pisa;<br />
4 University of<br />
Genova; 5 IRCCS Neurolesi “Bonino-Pulejo”, Messina<br />
252. The blink project: a new biome<strong>di</strong>cal researchers' database (www.doyoublink.net)<br />
Biggio Giovanni 3 , Busconi P. 1 , Ferranti S. 2 , Ceserani I. 3 , Pistotti V. 4 , Casale F. 3 , Caglioti L. 5 ,<br />
Garattini S. 4<br />
1 Promotore, Fondazione Schering, Italy – 2S Sviluppo tecnico database, New! S.a.s., Milano,<br />
Italy; 3 Società Italiana <strong>di</strong> Farmacologia, Milano, Italy - 4 Istituto <strong>di</strong> Ricerche Farmacologiche<br />
“Mario Negri”, Italy - 5 Università "La Sapienza", Roma, Italy<br />
253. On parenteral formulations and golden standards for quality and safety<br />
a Naccari C., b Giovinazzo C., a Saija A., a Tomaino A.<br />
a Dept. Farmaco-Biologico, Faculty of Pharmacy, University of Messina, Contrada Annunziata,<br />
98168 Messina, Italy; b Faculty of Pharmacy, University of Messina, Contrada Annunziata,<br />
98168 Italy<br />
Farmacognosia e fitoterapia: aspetti sperimentali e clinici<br />
Poster 254 – 265<br />
254. Central effects of a new secoisopimarane <strong>di</strong>terpenoid from aerial parts of Salvia<br />
cinnabarina<br />
Maione Francesco 1,2 , Colucci M. 2 , Bisio A. 3 , Romussi G. 3 , Pieretti S. 2 , Di Giannuario A. 2 , Maria<br />
C. Bonito M.C. 1,2 , Mascolo N. 1<br />
1 Department of Experimental Pharmacology, University of Naples “Federico II, Naples;<br />
2 Department of Drug Research and Evaluation, Italian National Institute of Health, Rome;<br />
3 Department of Chemistry and Pharmaceutical Technology and Alimentary, University of<br />
Genoa, Genoa<br />
255. In vitro antioxidant activity of aged extracts of some italian spontaneous Allium<br />
species<br />
Nencini Cristina, Micheli L., Giorgi G., Franchi G.G.<br />
Department of Pharmacology “Giorgio Segre”, University of Siena<br />
pag_sx.indd 1 30/05/2007 6.00.06
256. Effect of Allium neapolitanum on liver injury induced by ethanol in rats<br />
Nencini Cristina, Franchi G. G., Giorgi G., Micheli L.<br />
Department of Pharmacology “Giorgio Segre”, University of Siena<br />
257. Antioxidant properties of infusions from leaves and inflorescences of Achillea<br />
millefolium ssp. collina B. By use of chemical and biological assays<br />
Bombelli R. 1 , Luini A. 1 , Giorgi A. 2 , Licheri G. 2 , Carcano E. 1 , Marino F. 1 , Cosentino M. 1 ,<br />
Cocucci M. 2 , Lecchini S. 1<br />
1 Dipartimento <strong>di</strong> Me<strong>di</strong>cina Clinica, Sezione <strong>di</strong> Farmacologia Sperimentale e Clinica, Università<br />
<strong>degli</strong> <strong>Stu<strong>di</strong></strong> dell’Insubria, Varese and 2 Dipartimento <strong>di</strong> Produzione Vegetale, Università <strong>degli</strong><br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano, Milano<br />
258. In vitro antioxidant, antimutagen and anti-inflammatory activity of extracts and<br />
stilbenes from Glycyrrhiza glabra leaves<br />
1 Cristani M., 1 Saija A., 1 D’arrigo M., 1 Naccari C., 2 Ruberto G., 2 Bion<strong>di</strong> D.D., 1 Trombetta D.<br />
1 Dept. Farmaco-Biologico, School of Pharmacy, University of Messina, Italy - 2 CNR Institute of<br />
Biomolecular Chemistry - Catania, Valverde, Catania, Italy<br />
259. Protective effect of Hypericum perforatum in zymosan-induced multiple organ<br />
dysfunction syndrome<br />
1 De Sarro Angelina, 1,2 Mazzon E., 1,2 Di Paola R., 1 Muià C., 1,2 Genovese T., 2 Bramanti P.,<br />
3 Esposito E., 4 Menegazzi M., 3 Meli R., 4 Suzuki H., 1,2 Cuzzocrea S.<br />
1 Department of Clinical and Experimental Me<strong>di</strong>cine and Pharmacology, School of Me<strong>di</strong>cine,<br />
University of Messina, Italy; 2 IRCCS Centro Neurolesi "Bonino-Pulejo", Messina, Italy;<br />
3 Dipartimento <strong>di</strong> Farmacologia Sperimentale, Università <strong>di</strong> Napoli “Federico II”, Napoli, Italy;<br />
4 Department of Neuroscience and Vision, University of Verona, Verona, Italy<br />
145<br />
260. Inhibition of human cAMP phospho<strong>di</strong>esterases as a mechanism of the spasmolytic<br />
effect of Matricaria recutita L. water extract<br />
Dell’Agli Mario, Dal Cero E., Maschi O., Bosisio E.<br />
Department of Pharmacological Sciences, Faculty of Pharmacy, University of Milan, Italy<br />
261. Phenylpropanoid rich essential oils as potential antithrombotics endowed with<br />
gastroprotective effects<br />
Tognolini Massimiliano 1 , Barocelli E. 1 , Bertoni S. 1 , Impicciatore M. 1 , Bruni R. 2 , Ballabeni V. 1<br />
1 Dept of pharmacological, biological and applied chemical sciences. University of Parma. Viale<br />
Usberti 27/a, 43100 Parma, Italy; 2 Dept of evolutionary and functional biology. University of<br />
Parma. Viale Usberti 11/a, 43100 Parma, Italy<br />
262. Biological activity of bergamot peel extracts (Citrus bergamia Risso)<br />
Trombetta D., D’Arrigo M., Ginestra G., Arcoraci T., Mandalari G., Saija A., Cristani M.<br />
Dept. Farmaco-Biologico, School of Pharmacy, University of Messina - Vill. SS. Annunziata<br />
98168 Messina, Italy<br />
263. Evidence to implicate phospho-Akt (p-Akt) in the mechanisms underlying<br />
neuroprotection afforded by the essential oil of bergamot against excitotoxicity in<br />
vitro<br />
Maida Simona 1 , Fratto V., Navarra M. 1 , Bagetta G. 2 , Corasaniti M.T. 1<br />
1 Department of Pharmacobiological Sciences, University “Magna Graecia” of Catanzaro,<br />
Catanzaro, Italy; 2 Department of Pharmacobiology and University Centre of Adaptive<br />
Disorders and Headache (UCADH), section of Neuropharmacology of Normal and Pathological<br />
Neuronal Plasticity, University of Calabria, Rende (CS), Italy<br />
pag_dx.indd 1 30/05/2007 6.00.45
264. The protective effect of bergamot oil non volatile fraction on LOX-1 expression in<br />
balloon injury-related neointima formation<br />
Sacco Iolanda 1 , Palma E. 1 , Sculco F. 1 , Colica C. 1 , Visalli V. 1 , Muscoli S. 3 , Ragusa S. 1 ,<br />
Mondello L. 4 , Rotiroti D. 1 , Romeo F. 3 , Mollace V. 1,2<br />
1 Faculty of Pharmacy, University “Magna Graecia” of Catanzaro, Italy; 2 San Raffaele Pisana<br />
IRCCS, Rome, Italy; 3 Chair of Car<strong>di</strong>ology, University of Rome “Tor Vergata”, Rome, Italy;<br />
4 Faculty of Pharmacy, University of Messina, Italy<br />
265. Vascular activity of isolates from the Hyacinthaceae of south Africa<br />
Maida Simona 1 , Fratto V., Navarra M. 1 , Bagetta G. 2 , Corasaniti M.T. 1<br />
1 Department of Pharmacobiological Sciences, University “Magna Graecia” of Catanzaro,<br />
Catanzaro, Italy; 2 Department of Pharmacobiology and University Centre of Adaptive<br />
Disorders and Headache (UCADH), section of Neuropharmacology of Normal and Pathological<br />
Neuronal Plasticity, University of Calabria, Rende (CS), Italy<br />
Farmacogenetica, farmacogenomica e terapia genica<br />
Poster 266 – 280<br />
266. Olymorphisms of the ABCB1 gene pre<strong>di</strong>ct drug resistance in epileptic patients<br />
Lastella Marianna*, Danesi R.*, Cascio E.*, Jensen S. § , Iu<strong>di</strong>ce A. § , Murri L. § , Del Tacca M.*,<br />
Di Paolo A.*<br />
*Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine;<br />
§ Division of Neurology, Department of Neurosciences - University of Pisa<br />
146<br />
267. Herpes simplex vectors expressing FGF-2 and BDNF prompt neuronogenesis and<br />
exert <strong>di</strong>sease-mo<strong>di</strong>fying effects in a model of temporal lobe epilepsy<br />
Mazzuferi Manuela 1 , Para<strong>di</strong>so B. 1 , Marconi P. 1 , Zucchini S. 1 , Berto E. 1 , Binaschi A. 1 , Bozac A. 1 ,<br />
Buzzi A. 1 , Magri E. 1 , Navarro Mora G. 2 , Ro<strong>di</strong> D. 1 , Volpi I. 1 , Fabene P.F. 2 , Marzola A. 1 ,<br />
Manservigi R. 1 , Simonato M. 1<br />
1 University of Ferrara, 2 University of Verona, Italy<br />
268. Alzheimer's <strong>di</strong>sease: association study between response to cholinesterase<br />
inhibitors and can<strong>di</strong>date genes in a sar<strong>di</strong>nian sample<br />
Squassina Alessio 1 , Congiu D. 1 , Manconi F. 1 , Putzu P.F 2 , Chillotti C. 1 , Del Zompo M. 1 , Piccar<strong>di</strong><br />
M. 1<br />
1 Unit of Clinical Pharmacology, Department of Neurosciences ‘‘B. B. Bro<strong>di</strong>e’’, University of<br />
Cagliari, 2 Division of Geriatrics, Local Health Agency 8, Cagliari, Italy<br />
269. Impact of CYP3A4 and CYP3A5 polymorphisms on clinical outcome of donepezil in<br />
Alzheimer's <strong>di</strong>sease patients<br />
Paoletti T. 1 , Scordo M.G. 2 , Miglio G. 1 , Villa M.L. 3 , Dahl M.L. 2 , Lombar<strong>di</strong> G. 1<br />
1 DISCAFF Department, University of “Piemonte Orientale Amedeo Avogadro”, Novara, Italy;<br />
2 Department of Me<strong>di</strong>cal Sciences, Clinical Pharmacology, Uppsala University Hospital,<br />
Uppsala, Sweden; 3 Geriatric Clinical Unit, “ Ospedale Maggiore della Carità”, Novara, Italy<br />
270. Role of polymorphisms of the UGT1A9 gene in comt inhibitor-induced hepatotoxicity<br />
in parkinson's <strong>di</strong>sease: a clinical study<br />
1 Ferrari Marco, 1 Cosentino M., 1 Marino F., 1 Bono G., 2 Martignoni E., 3,4 Nappi G., 1 Lecchini S.<br />
1 Dept. Clin. Med., University of Insubria, Varese, 2 Dept. Med. Sci., University of Piemonte<br />
Orientale “Amedeo Avogadro”, Novara and Dept. Neurorehabil. Mov. Disord., “Salvatore<br />
Maugeri” Foundation, Scientific Institute of Veruno, NO, 3 Dept. of Neurol. Otorhinolaryngol.,<br />
University “La Sapienza”, Rome, and 4 I.R.C.C.S. C. Mon<strong>di</strong>no, Pavia, Italy<br />
pag_sx.indd 1 30/05/2007 6.01.35
271. Genetic polymorhisms of serotonin transporter and monoamine oxidase; and<br />
response to SSRI antidepressant drugs in terminal cancer patients<br />
Schillani Giulia, Capozzo M., Conte A.M., De Vanna M., Giral<strong>di</strong> T.<br />
Department of Biome<strong>di</strong>cal Sciences, University of Triest<br />
272. Lithium response: association study with can<strong>di</strong>date genes<br />
Manchia Mirko, Squassina A., Lampus S., Ardau R., Chillotti C., Del Zompo M., Severino G.<br />
Section of Clinical Pharmacology, Department of Neurosciences “B.B. Bro<strong>di</strong>e”, University of<br />
Cagliari<br />
273. Pharmacogenomics and triptans: a pilot study of association between clinical<br />
response to rizatriptan and some can<strong>di</strong>date genes<br />
Asuni Carlo, Stochino M.E., Congiu D., Cherchi A., Piccar<strong>di</strong> M. P., Del Zompo M.<br />
Headache Centre, Section of Clinical Pharmacology, Department of Neurosciences “B.B.<br />
Bro<strong>di</strong>e”, University of Cagliari<br />
274. Synergistic cytotoxicity of oxaliplatin and pemetrexed in colon cancer cells: cellular<br />
and molecular mechanisms<br />
Nannizzi Sara, Giovannetti E., Mey V., Ricciar<strong>di</strong> S., Del Tacca M., Danesi R.<br />
Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />
Pisa<br />
275. Molecular mechanisms underlying the synergistic interaction of the EGFR tyrosine<br />
kinase inhibitor erlotinib with the multitargeted antifolate pemetrexed in non-small<br />
cell lung cancer cells<br />
Giovannetti Elisa 1,2 , Smid K. 1 , Mey V. 2 , Tekle C. 1 , Nannizzi S. 2 , Rodriguez J.A 1 , Ricciar<strong>di</strong> S. 2 ,<br />
Del Tacca M. 2 , Giaccone G. 1 , Danesi R. 2 , Peters Godefridus J 1<br />
1 Dept. Me<strong>di</strong>cal Oncology, VU University Me<strong>di</strong>cal Center, Amsterdam, The Netherlands; 2 Dept.<br />
Internal Me<strong>di</strong>cine, Div. Pharmacology and Chemotherapy, University of Pisa, Italy<br />
147<br />
276. Pharmacogenetic evaluation of Aurora A kinase in colorectal cancers<br />
Amatori Federica Maria*, Boldrini L § , Di Paolo A*, Lastella M*, Fontanini G § , Del Tacca M*,<br />
Danesi R*.<br />
*Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine; § Division of<br />
Pathology, Department of General Surgery, University of Pisa<br />
277. Epigenetic mechanisms of sensitivity to irinotecan in colorectal cancer cell lines<br />
Crea Francesco, Giovannetti E., Mey V., Nannizzi S., Ricciar<strong>di</strong> S., Danesi R., Del Tacca M.<br />
Division of Pharmacology and Chemotherapy, Department of Internal Me<strong>di</strong>cine, University of<br />
Pisa, Pisa, Italy<br />
278. Genetic polymorphisms in DNA repair genes and their impact on susceptibility to<br />
multiple myeloma<br />
Angelini Sabrina 1 , Cantelli-Forti G. 1 , Terragna C. 2 , Renzulli M. 2 , Cavo M. 2 , Hrelia P. 1<br />
1 Department of Pharmacology, University of Bologna; 2 Institute of Haematology and Me<strong>di</strong>cal<br />
Oncology “Seragnoli”, University of Bologna<br />
279. Genetic polymorphism of bleomycin hydrolase: a new biomarker for human<br />
mutagen sensitivity<br />
Maffei Francesca 1 , Carbone F. 1 , Angelini S. 1 , Cantelli Forti G. 1 , Norppa Hannu 2 , Hrelia P. 1<br />
1 Department of Pharmacology, University of Bologna, Via Irnerio 48 40126 Bologna, Italy;<br />
2 Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FI-00250 Helsinki, Finland<br />
pag_dx.indd 1 30/05/2007 6.02.14
280. DNA vaccine strategy against chronic B-cell lymphoma: anti-i<strong>di</strong>otypic CDR3<br />
vaccination<br />
Schirru Cristina 1 , Maullu C. 1 , Deidda F. 1 , Rinal<strong>di</strong> M. 3 , Signori E. 2,3 , Massi E. 2 , Chiarella P. 1,2 ,<br />
Marelli O. 4 , Tonon G. 1 , Fazio V.M. 2,3<br />
1 Bioker S.r.l. Polaris Loc.piscinamanna Pula (CA); 2 CIR, Section of Molecular Me<strong>di</strong>cine and<br />
Biotechnology, University "Campus Bio-Me<strong>di</strong>co", Rome, Italy; 3 Institute of Neurobiology and<br />
Molecular Me<strong>di</strong>cine, CNR Rome, Italy; 4 Dipartimento Di Farmacologia, Chemioterapia E<br />
Tossicologia Me<strong>di</strong>ca, Università <strong>di</strong> Milano<br />
148<br />
pag_sx.indd 1 30/05/2007 6.03.02
38<br />
pag_sx.indd 1 30/05/2007 7.14.27
Aas M 131<br />
Abbadessa G 108<br />
Abbate R 120<br />
Abbate M 43<br />
Abbracchio M 35, 126<br />
Abbruzzese A 128<br />
Abdelrahman M 133<br />
Accomazzo MR 102<br />
Acquadro E 88<br />
Acquas E 96, 130<br />
Adami M 98<br />
Adamo E 58, 135<br />
Adcock I<br />
Adornetto A<br />
Agnati LF 30<br />
Agnoletto L 78, 117<br />
Agostini M 103,<br />
Agostini S 98, 99, 135<br />
Agresta A 129, 130<br />
Agretti P 113<br />
Agrusa A 138<br />
Aguglia E 28, 38, 66<br />
Aiello A<br />
Aimola P 109<br />
Akpan V 137<br />
Alacqua M 111, 124, 143<br />
Alaimo A 104<br />
Albanese A 128<br />
Albini A 81<br />
Alboni S 62, 85<br />
Alcaro S 136<br />
Alderighi D 104<br />
Alemà GS 123, 126<br />
Alfieri A 134<br />
Alicandri C 106<br />
Aliferopulos H 111<br />
Allegretti M 138<br />
Allegrini G 138<br />
Alloisio S 81, 112<br />
Almairac R 120<br />
Altamura CA 28, 38<br />
Altavilla D 54, 58, 101, 117,<br />
126, 127 , 135, 136<br />
Altea S 130<br />
Altieri V 142<br />
Ama<strong>di</strong>o M 98<br />
Ama<strong>di</strong>o S<br />
Amantea D 43<br />
Amato D 86, 93<br />
Amatori FM 59, 142, 147<br />
Ambrosio C 78<br />
Amici A 59<br />
Amoroso S 31, 37, 115<br />
Amoruso A 35, 37, 140<br />
Anania V 108<br />
Andersen SJ 93<br />
Andre E 131, 132<br />
Andreassi MG<br />
Andretta F 127<br />
Angeli A 58<br />
Angelini S 147<br />
Angeloni C 88<br />
Angioni MM 88<br />
Angius F 130<br />
Anichini R 100<br />
Annibale R 144<br />
Annunziato L 35, 63, 77, 81, 110,<br />
126<br />
Antenucci G 113<br />
Antonelli T 31<br />
Antonioli L 98, 134<br />
Antonuccio P 101<br />
Anzellotti P 84, 102<br />
Apicella C 102<br />
Appen<strong>di</strong>no G 47<br />
Aquaro S<br />
Aquilani R 84<br />
Aquino RP 108<br />
Arbitrio M 87, 93<br />
Arcieri P 57, 90<br />
Arcone R 93, 128<br />
Arcoraci T 145<br />
Arcoraci V 107, 124, 143<br />
Ardau R 106, 147<br />
Argiolas A 101, 130<br />
Armida M 82<br />
Armocida G 121<br />
Arnabol<strong>di</strong> L 121<br />
Arnoletti E 100, 135, 136<br />
Aronica E 126<br />
Ascolani A 116<br />
Assaretti AR<br />
Asuni C 143, 147<br />
Autore G 83, 108, 119, 120<br />
Avallone R 121, 136<br />
Avanzini G 117<br />
Aviello G 58<br />
Ayrol<strong>di</strong> E 58<br />
Azad S 118<br />
Azzena G<br />
Babini E 115<br />
Baccini G 118<br />
Bachis E 76<br />
Bacosi E 96<br />
Badalamenti G 138<br />
Bader G 48<br />
Bader M 99<br />
Ba<strong>di</strong>ani A 93, 96, 97<br />
Badura A<br />
Baetta R 121<br />
Bagetta G 43, 44, 65, 145, 146<br />
Baggio G 103, 139<br />
Baigent C 29<br />
Baiula M 58, 137<br />
Bajetto A 79<br />
Balduini W 65, 127<br />
Balestra B 135<br />
Balestrieri E 28, 116<br />
Ballabeni V 118, 134, 145<br />
Ballerini P 35<br />
Ballerini C 140<br />
Banchelli G 107<br />
Banfi F 143<br />
Bani D 132<br />
Bano F 107<br />
Barabino A 109<br />
Barabino E 36<br />
Baragli A 100,135<br />
Baral<strong>di</strong> M 58, 82, 101, 102, 121,<br />
136, 137<br />
Baral<strong>di</strong> PG 28, 37, 89<br />
Barberi L 128<br />
Barberis A 59, 104<br />
Barbierato M 78<br />
Barbieri A 113, 117<br />
Barbieri F 79<br />
Barbieri R 112<br />
Barbieri M 122<br />
Barbieri S 54<br />
Barbiero V 85<br />
Bardella E 99<br />
Bardelli C 35, 37, 140<br />
Barden N 62<br />
Barillari J 108<br />
Barletta MT 138<br />
Barnes A 78<br />
Barnes P 32<br />
Barnett A 100<br />
Baroc MF 91<br />
Barocelli E 118, 134, 145<br />
Baroffio M 133<br />
Barone D 137<br />
Barone E 127<br />
Barraco A 141<br />
Barrese V 81<br />
Barrile V 94<br />
Bartella C 102<br />
Bartesaghi S<br />
Bartoli F 104, 109, 110<br />
Bartolini A 92, 116, 43<br />
Bassi A 95, 107<br />
Basta F 102<br />
Bastia E 80, 114<br />
Bastianelli A 58, 80<br />
Bastoni S 111<br />
Battaglia G 65, 87, 88, 7, 116,<br />
126,<br />
Battisti E 128<br />
Batuwangala M 114<br />
Bazzani C 53, 117, 126<br />
Bazzu G 36, 64, 90, 94<br />
Beani L 122<br />
Bechi P 83<br />
Be<strong>di</strong>ni A 113<br />
Belfiore D 36<br />
Bellanti F 91<br />
Bellantuono C 28, 39, 141<br />
Bellik L 48, 54, 59<br />
Bellini G 35<br />
Bellini M 109<br />
Bellis A 100, 110<br />
Bellosta S 121, 43<br />
Belluardo N 65<br />
Bellucci A 140<br />
Beltramo M 76<br />
Benatti C 62, 85<br />
Bencini A 102<br />
Benelli A 79, 101<br />
Benemei S 129<br />
Benincasa M 79<br />
Benini A 37, 61, 112<br />
Benoni G 107<br />
Bergersen L<br />
Bernar<strong>di</strong>ni N 98<br />
Bernar<strong>di</strong>ni R 43, 81<br />
Bernini F 121<br />
Berrino L 37, 38, 53, 84, 115,<br />
120<br />
Berta GN 59, 104<br />
Berta L 104<br />
Bertacca L 116<br />
Bertarione Rava Rossa L 137<br />
Bertelli L 142<br />
Berti F 48, 83, 121<br />
Berti M 83<br />
Bertini R 138<br />
Berto E 146<br />
Bertocchi I 88<br />
Bertolini A 30, 31, 53, 105, 125,<br />
130<br />
Bertoni S 79, 118, 134, 145<br />
Bertorelli R 50<br />
Bertossi F<br />
Betti N 80<br />
Bettiol E<br />
Bettoni I 129<br />
Bezzi P 44<br />
Biagi GL 108<br />
Biagi M 136<br />
152
Biagioli T 140<br />
Biagioni F 87, 97, 126<br />
Biamonte F 140<br />
Bianchi A 129, 130<br />
Bianchi F 98<br />
Bianchi M 83<br />
Bianco F<br />
Bianco G 83, 100, 108, 119, 135<br />
Biasin A<br />
Bifulco M 76, 108<br />
Biggio F 61, 85, 131<br />
Biggio G 26, 27, 30, 36, 38, 53,<br />
56, 61, 66, 76, 77, 82, 85, 88,<br />
95, 131, 144<br />
Billington RA 115<br />
Bin A 107, 134<br />
Binaschi A 146<br />
Bion<strong>di</strong> DM 145<br />
Bion<strong>di</strong> S 102, 114<br />
Bisio A 144<br />
Bisogno A 129, 130<br />
Bitto A 54, 58, 101, 117, 120,<br />
126, 127, 135, 136<br />
Bizzarri C 138<br />
Bizzarro V 79<br />
Blan<strong>di</strong>na P 114, 125<br />
Blan<strong>di</strong>zzi C 42, 59, 60, 98, 106,<br />
109, 110, 134, 143<br />
Blasevich M 124<br />
Blom JMC 62, 85<br />
Bocci G 59, 81, 138<br />
Boccuti S 37<br />
Boldrini L 147<br />
Bolego C 57, 83, 101<br />
Bolla M<br />
Bolle P 109<br />
Bombar<strong>di</strong>eri S 110<br />
Bombelli R 50, 140, 145<br />
Bonamassa B 108<br />
Bonanno G 81, 82, 105<br />
Bonatesta RR 111<br />
Boncompagni E 117<br />
Bongers G 114<br />
Bonini SA 65,124<br />
Bonito MC 144<br />
Bono A 142<br />
Bono G 146<br />
Bonomo SM 83, 135<br />
Bonuccelli U<br />
Borea PA 28, 37, 61, 112, 133<br />
Borghi V 102<br />
Borner Perrone I 105, 142<br />
Borracci P 36<br />
Borrelli F 58<br />
Borroni E 102<br />
Borsini F 51, 86, 89<br />
Bortolato M 94<br />
Boschi F 84, 99, 142<br />
Boscia F 77, 126<br />
Bosisio E 145<br />
Bossi M 110<br />
Bothmann H 92<br />
Botta M 79, 136<br />
Botta P 36<br />
Bottai D 125, 127<br />
Bottelli A 121<br />
Botti F 60<br />
Botticelli A 117, 126<br />
Bottinelli R<br />
Bova S 119<br />
Bozac A 146<br />
Bozzo L 112<br />
Braconi S 93, 132<br />
Braghiroli D 121<br />
Braida D 61, 97<br />
Bramanti P 38, 66, 79, 133, 145<br />
Brambilla M 54, 119<br />
Brancaleone V 54, 83, 133<br />
Brassart L 111<br />
Brausi M 142<br />
Breckenridge A 46<br />
Breghi L 54<br />
Brera F 89<br />
Breschi MC 134<br />
Bresciani E 136<br />
Bretoni L<br />
Brini AT 111<br />
Brivio I 119<br />
Brocadello F 107<br />
Broccardo M 98, 99, 135<br />
Broccoli M 134<br />
Brockmann MD 131<br />
Brodows D<br />
Brodows RG 99, 100<br />
Brogioni S<br />
Brown J 141<br />
Brucato L 58<br />
Brun P 134<br />
Brunelleschi S 35, 37, 140<br />
Brunelli S<br />
Brunello N 33, 62, 85<br />
Bruni E 103, 139<br />
Bruni R 145<br />
Bruno V 65, 87, 88, 96, 97, 126<br />
Bruno A 138<br />
Brusa R 76<br />
Bruscoli S 58, 80, 103, 137<br />
Brusoni B 54<br />
Buanne P 138<br />
Buccellati C 101, 119<br />
Bucci M 54, 83, 133<br />
Buccianti P 134<br />
Buckingham J 33<br />
Bucolo C 137<br />
Buiatti E<br />
Buitelaar JK<br />
Bulgarelli I 136<br />
Bunnett NW 131<br />
Buonocore G 127<br />
Bur<strong>di</strong> R 127<br />
Busceti C 97, 126<br />
Busconi P 144<br />
Bushe C 141<br />
Buti D 105<br />
Butt A 131<br />
Buzzi A 117, 146<br />
Bymaster B 56<br />
Caboi F 110, 111<br />
Cabras A 65, 110<br />
Cabras S 85<br />
Caccia C 93<br />
Caccia S<br />
Cacciapaglia F 96<br />
Caciagli F 28<br />
Caderni G 137<br />
Caffino L 118<br />
Caggia F 62, 85<br />
Cagliati L 144<br />
Cagnar<strong>di</strong> P 130<br />
Cajozzo M 138<br />
Calabrese F 85<br />
Calabrese V 128<br />
Calabresi L 54, 84, 121<br />
Calafiore M 116<br />
Calapai G 95, 97, 99, 107, 130,<br />
144<br />
Calascibetta A 138<br />
Calcagno E<br />
Calciano S 81, 84<br />
Calderoni S 106<br />
Calia G 64, 79, 90, 94<br />
Calignano A 42, 50, 128, 136<br />
Calixto J 99<br />
Calligaro G 134<br />
Calò G 49, 122, 132<br />
Calò L<br />
Caltagirone C 116<br />
Calza A 88<br />
Camarda V 78, 114<br />
Camera M 54, 119<br />
Camerino GM 47, 127<br />
Cammarano M 124<br />
Campana G 123, 130<br />
Campese A 50<br />
Campesi I 57, 100<br />
Campi B 131, 132<br />
Campioli E 121, 136<br />
Campolongo P 94<br />
Canapaio R 104, 111<br />
Canavesi M 121<br />
Canciani L 98<br />
Candeletti S 92, 97<br />
Can<strong>di</strong>ani S 79<br />
Caldura SM 133<br />
Candussio L 104<br />
Canetta A<br />
Caniglia S 57, 64, 90<br />
Canistro D 108<br />
Cannarile L 137<br />
Cannella N 97, 132<br />
Cannizzaro C 94, 95<br />
Cannizzaro E 94<br />
Cannizzaro G 94, 95, 88, 131<br />
Canonico PL 41, 60, 104, 115,<br />
123, 125<br />
Cantalamessa F 108<br />
Cantara S 91<br />
Cantarella G 81<br />
Cantelli Forti G 39, 58, 88, 147<br />
Cantoni O 64, 117<br />
Cantore M 102<br />
Canu S 57, 100<br />
Canzoniero LMT<br />
Corsi V 90<br />
Capaccioli S 80<br />
Caparrotta L 81, 83<br />
Capasso A 76, 88, 93, 107, 123,<br />
124, 129, 130<br />
Capasso F 58<br />
Papasso R 58<br />
Capecchi PL 28<br />
Capellino S 49<br />
Capone J 129<br />
Capone ML 47, 54, 84<br />
Capone G 85<br />
Capozzo M 147<br />
Cappa M 124<br />
Cappetta D 47<br />
Cappuccio I 77<br />
Capra V 133<br />
Caprioli D 96, 97<br />
Capuano A 47, 107, 120, 143<br />
Capurro V 61, 97<br />
Caputi AP 29, 38, 40, 53, 54, 58,<br />
66, 95, 97, 99, 101, 107, 111,<br />
120, 127, 135, 136, 138, 143,<br />
144<br />
Caraci F 91, 116<br />
Canaglia M 128<br />
153
Caramelli A 89<br />
Caramori G 133<br />
Carangi R 119<br />
Carbonara G 115<br />
Carbonaro V 91<br />
Carbone F 147<br />
Carcano E 50, 140, 145<br />
Caria S 61, 85, 131<br />
Caricasole A 46, 78, 92, 113, 126<br />
Carina V 104<br />
Carissimi R 124<br />
Carletti F 88<br />
Carletti M 108<br />
Carlin A 53<br />
Carloni S 65,127<br />
Carlucci F 117<br />
Carmassi C 142<br />
Carmignani M 60, 109<br />
Carminati P 89<br />
Carnini C 102<br />
Carnuccio R 43, 111, 116<br />
Carone C 30<br />
Caronno A 110, 139<br />
Carra’ G 78<br />
Carratù MR 36<br />
Carretta MT 96<br />
Carru C 57<br />
Carruba M 67<br />
Carta AR 89<br />
Carta D 94<br />
Carta M 36, 76, 77, 131<br />
Carta P 142, 143<br />
Carta S 57<br />
Carullo P 119<br />
Carusio N 37<br />
Caruso A 78, 86, 96, 112, 113<br />
Caruso M 61<br />
Casadonte R 89<br />
Casale F 62, 128, 144<br />
Casamenti F 46, 90, 91, 140<br />
Cascino A 120<br />
Cascio E 146<br />
Casini P 128<br />
Casini L 105<br />
Casnici C 140<br />
Casolari P 123, 126<br />
Cassano T 31, 89, 91, 118<br />
Castagliuolo I 134<br />
Castagnola P 79<br />
Castaldo P 31, 35, 115<br />
Castellana CR 130, 135<br />
Castelli MP 94<br />
Castelli P 139<br />
Casti P 76, 123<br />
Castiglioni L 139<br />
Castiglioni C<br />
Castrignanò S 57, 123<br />
Casu G 76, 123<br />
Casula MG 94<br />
Catalani A 123, 126<br />
Catalano A 114<br />
Catania MA 53, 107, 111, 116,<br />
117, 118, 123, 125, 128, 144,<br />
145<br />
Catania A 53, 107, 111, 116,<br />
117, 118, 123, 125, 128, 144,<br />
145<br />
Catena M 142<br />
Cathalà A<br />
Cattabeni F 65<br />
Cattaldo S 106<br />
Cattaneo A 85<br />
Cattaneo E<br />
Cattaneo MG 38, 57<br />
Cattarini G 120<br />
Cavaliere F 65<br />
Cavallesco G<br />
Cavalli M 119<br />
Cavalli R 106<br />
Cavallo F 59, 88<br />
Cavallo P 76<br />
Cavani F 79<br />
Cavo M 147<br />
Ceccarelli L 110<br />
Cecchi E 107<br />
Celano M 79, 136<br />
Celentano M 96, 97, 125<br />
Cella S 40, 135<br />
Centenaro C 119<br />
Ceolotto G 119<br />
Cerbai E 45, 47, 59<br />
Cereda E 139<br />
Cerioni L 117<br />
Cerretani D 128, 138<br />
Cerulli A 65<br />
Ceruti S 35<br />
Cervetto C 62, 79, 112<br />
Cervio E 99, 135<br />
Cervo L<br />
Cesare P 60, 94, 109, 116, 120,<br />
128<br />
Ceserani I 144<br />
Changeux JP 30, 117<br />
Chazot P 125<br />
Cherchi A 147<br />
Chiappetta G 138<br />
Chiaravalli A 98<br />
Chiarella P 148<br />
Chiarugi A 114, 127<br />
Chiarugi M 134<br />
Chiesa G 48<br />
Chiesara E 40, 48, 108<br />
Chikhladze M 117<br />
Chillotti C 106, 146, 147<br />
Chimirri A 87<br />
Chinellato A 40, 48<br />
Chini B 57<br />
Chirafisi J 128<br />
Chiroli S 40<br />
Christian H<br />
Ciampi O<br />
Cianchi F 80<br />
Ciapparelli A 142<br />
Cicala C 134<br />
Ciccarelli R 86<br />
Ciccocioppo R 41, 49, 93, 97,<br />
122, 123, 132<br />
Ciceroni C 77<br />
Cifani C 122<br />
Cifelli G<br />
Cignarella A 57, 83<br />
Cigognini D 125<br />
Cilio MR 35<br />
Cillo U 117<br />
Cimino F 109, 128<br />
Cimino M 126<br />
Cimpanelli MG 139<br />
Cinci L 102<br />
Cinotti S 120<br />
Cinque C 114, 123, 126<br />
Ciofi L 59, 142<br />
Cioppa T 138<br />
Cipollaro M 120<br />
Cipollini F 107<br />
Cipollone F 60<br />
Cippitelli A 93, 123, 132<br />
Cippone V 47, 115, 127<br />
Cipriani S 61<br />
Cirino G 32, 54, 55, 64, 83, 101,<br />
133<br />
Citraro R 86, 87<br />
Citro S 133<br />
Ciuffi M 102<br />
Clementi E 64<br />
Coccia C 105, 130<br />
Cocco GA 76<br />
Cocucci M 145<br />
Coinu R 57, 140<br />
Colaianna M 57, 123<br />
Colangelo D 104<br />
Colavito D 91<br />
Coletta I 102<br />
Coletta T 84<br />
Colica C 128, 146<br />
Colleoni M 61, 129<br />
Collier D 131<br />
Collino M 48, 58<br />
Collura D 88<br />
Colnago D 54<br />
Colombo A<br />
Colombo C 139<br />
Colombo G 53<br />
Colombo ML 140<br />
Colucci MA 42, 93, 122, 144<br />
Colucci R 98, 109, 110, 134<br />
Coluccia A 36<br />
Comazzi M 124<br />
Comelli F 61, 129<br />
Comhair S 132<br />
Comi G 50<br />
Compostella F 140<br />
Conal<strong>di</strong> G 121<br />
Concas A 35, 62, 88<br />
Concas D 111<br />
Con<strong>di</strong>no AM 113, 117<br />
Condorelli F 104, 115<br />
Confalonieri P 127<br />
Congiu D 146, 147<br />
Consoli D 36<br />
Consoli G 142<br />
Consoli GML 80<br />
Constanti A 87<br />
Conte AM 147<br />
Conte Camerino D 36, 45, 47,<br />
114, 115<br />
Conti A 140<br />
Conti S 50<br />
Conti V 37<br />
Conti L<br />
Contis M 111<br />
Conzen S<br />
Copani A 41, 91, 116, 123<br />
Coppi A 103, 139<br />
Coppi G 139<br />
Coppi E 113<br />
Corasaniti T 43, 65, 145, 146<br />
Corbi GM 37<br />
Corbo F 115<br />
Corcione E 31, 115<br />
Corda G 76<br />
Corinaldesi R 99<br />
Cornaglia G<br />
Cornelli L 48<br />
Corona C<br />
Corrao G 40<br />
Corsaro A 79<br />
Corsello S 107<br />
Corsi L 57, 58, 102<br />
Corsi M 124<br />
154
Corsini A 83, 121<br />
Corsini E 137<br />
Corsini G 113, 89<br />
Corsini D 62, 85<br />
Corso G 138<br />
Corso M 78<br />
Corti F 80<br />
Corti C 65<br />
Coruzzi G 98<br />
Cosco D 136<br />
Cosentino M 49, 50, 139, 140,<br />
145, 146<br />
Cossu G 30<br />
Costa B 61, 129<br />
Costa F 110<br />
Costa N 84, 87, 93<br />
Costantino L 31, 125<br />
Costantino M 128<br />
Costantino S 77<br />
Cotrufo M 120<br />
Cottrell G 131<br />
Covarello D<br />
Cozza G 81<br />
Cozzi A 115<br />
Cozzoli A 127<br />
Cozzolino A 128<br />
Crea F 147<br />
Crema F 98<br />
Crepal<strong>di</strong> T 136<br />
Crescimanno M 138<br />
Crespi C 139<br />
Cricelli C 39, 40, 52, 63<br />
Crimi E 133<br />
Criollo A 116<br />
Crisafulli C 66, 103<br />
Cristalli G<br />
Cristani MT 128, 145<br />
Cristante T<br />
Perrotta C<br />
Cristino L 76, 100<br />
Cristita P 132<br />
Crobu D 110<br />
Croci T 134<br />
Crotta K 140<br />
Crouch N<br />
Cuboni S<br />
Cuccurullo C<br />
Cuccurullo F<br />
Cuda G 87<br />
Cuomo O 126<br />
Cuomo V 30, 31, 34, 57, 89, 90,<br />
91, 94, 118, 123, 125<br />
Cupani C<br />
Curatolo P 141<br />
Curcuruto R 144<br />
Curinga C 87<br />
Currò D 97<br />
Curti D 60<br />
Cusinato F 78, 117<br />
Cutroneo P 144<br />
Cutroneo PM 143<br />
Cuzzocrea S 38, 50, 55, 66, 100,<br />
103, 120, 133, 137, 138, 145<br />
Cuzzolaro M 95<br />
Cuzzolin L 107<br />
Cvorovic J 104<br />
D’Addario C 97<br />
Da Settimo F 134<br />
Dacasto M 108<br />
D'Acquisto F 102<br />
D'Acunto CW 59<br />
Daffara F 58<br />
D'Agostino B 132, 133, 32, 49<br />
D'Agostino G 42, 50, 113, 117,<br />
128, 129<br />
D'Agostino S 88<br />
Daina Economidou 132<br />
Dal Ben D<br />
Dal Cero E 145<br />
Dal Piaz V 93<br />
D'Alessandro N 37, 104, 110<br />
D'Alfonso R 104<br />
D'Alimonte I<br />
Dalle Carbonare M 91<br />
Dall'Olio R 123, 132<br />
Damiano V 37<br />
D'Amico A 98, 137<br />
D'Amico M 81, 84, 136<br />
D’Amico Monia 81, 84, 136<br />
D'Amico D 96<br />
Danesi R 50, 59, 81, 103, 138,<br />
142, 146,147<br />
D'Anna R 58, 135<br />
D'Antona G<br />
Daperno M 111<br />
D'Aquila PS 94<br />
Darnaudery M<br />
D'Arrigo A 91<br />
D'Arrigo C 124<br />
D'Arrigo M 145<br />
Dattolo MG 136<br />
D'Auro M 86<br />
Dahl ML 146<br />
Davoli A 105, 142<br />
Dazzan P 131<br />
Dazzi L 56, 82, 85<br />
De Amici E 133<br />
De Angelis S 133<br />
De Angelis A 47<br />
De Bellis M 115<br />
De Bellis A 100<br />
De Bene<strong>di</strong>ctis L 119<br />
De Esch Iwan IP 98<br />
De Fazio P 126<br />
De Fazio S 106<br />
De Filippis D 43, 137, 90, 91, 98<br />
De Francia S 58<br />
De Gennaro Colonna V 83, 121<br />
De Giorgi A 123<br />
De Giorgio R 99, 135<br />
De Girolamo L 111<br />
De Gruttola L 83, 133<br />
De Iu<strong>di</strong>cibus S 110<br />
De Libero G 140<br />
De Lisa R<br />
De Luca A 47, 115, 127<br />
De Luca MA 86<br />
De Luca N 110<br />
De Luca P 120<br />
De Luca V 98<br />
De Man J 98<br />
De Marco T 97<br />
De Martin S 142<br />
De Martino F 58<br />
De Mattei M 112<br />
De Matteis F 109<br />
De Metrio M 54<br />
De Nardo M 132, 133<br />
De Novellis V 43, 47, 92<br />
De Petrocellis L 76, 129<br />
De Ponti F 42, 134, 135<br />
De Rosa G 111<br />
De Salvia MA 94<br />
De Santi S 102<br />
De Sarro A 35, 99, 138<br />
De Sarro G 40, 80, 86, 87, 105,<br />
106, 126, 132, 142<br />
De Siena G 129<br />
De Stefano D 43, 47, 111<br />
De Vanna M 147<br />
De Vita T 78<br />
De Winter B 98<br />
Deambrosis P 48<br />
Debutto P 78<br />
Decorti G 104, 109, 110, 119<br />
Dedola S 36, 79, 94<br />
Dedoni S 65, 86, 126<br />
Deghenghi R 135<br />
Deidda F 148<br />
Del Basso Orsini P 84<br />
Del Bufalo D 138<br />
Del Duca C<br />
Del Giu<strong>di</strong>ce E 91<br />
Del Soldato P 48<br />
Del Tacca M 103, 106, 109, 110,<br />
134, 138, 142, 143, 144, 416,<br />
147, 40, 42, 59, 81, 98<br />
Del Vecchio I 128, 137<br />
Del Zompo M 29, 106, 142, 143,<br />
146, 147<br />
Delfino D 140<br />
D'Elia P 109<br />
Della Bianca A 133<br />
Dell'Agli M 145<br />
Dell'Agnello G 56, 141<br />
Dell'Osso L 142<br />
Demma I 135<br />
D'Emmanuele Di Villa Bianca R<br />
101, 119, 120<br />
Demontis MP 51, 108<br />
Dempster D 39, 131<br />
Desaphy JF 36, 114, 115<br />
Desideri M 138<br />
Desole MS 47, 79<br />
Dessì C 125<br />
Devono G<br />
Di Benedetto M 97<br />
Di Carlo F 58, 59, 104, 108<br />
Di Carlo S 96<br />
Di Cesare Mannelli L 116<br />
Di Chiara G 51, 86, 96, 130<br />
Di Febbo C 54<br />
Di Filippo C 84, 136<br />
Di Forti M 131<br />
Di Francesco L 47, 102, 84<br />
Di Giannuario A 122, 144, 42, 93<br />
Di Giulio AM 79, 125, 127<br />
Di Giuseppe D 108, 120, 121<br />
Di Gregorio P 84<br />
Di Iorio P<br />
Di Lorenzo A 54, 83, 133<br />
Di Luca M 41, 65<br />
Di Marzo V 34, 43, 47, 76, 100,<br />
129<br />
Di Matteo A 102<br />
Di Paola R 66<br />
Di Paolo A 59, 138, 142, 146,<br />
147<br />
Di Pardo A 113, 119<br />
Di Pirro M 107<br />
Di Renzo G 110, 126<br />
Di Simplicio P 108, 120, 121<br />
Di Stefano A 108<br />
Di Stefano R 110<br />
Di Stefano V 54, 120, 127<br />
Di Toro R 113, 58<br />
Di Vita G 124<br />
Diana Estello M<br />
155
Diana M 131, 36, 41, 43, 51, 95,<br />
96<br />
Diani E 48<br />
Dianzani C 48, 58<br />
Diaspro A 90<br />
Di Giannuario A 42, 122, 144<br />
Diliberto I 95<br />
Dimida A 113<br />
Diodato E 92<br />
Di Palma A 114, 36<br />
Di Pasquale P 125<br />
Distasi C 125<br />
Dolora P 137<br />
Domenica MR 82, 118, 126<br />
Donati E 102, 113<br />
Donati V<br />
Donato G 126<br />
Donato V 137, 58<br />
Donniacuo M 47, 120<br />
Donnini S 91, 101, 118, 119<br />
Dore B 94<br />
Dore R 88, 36<br />
Dorent R 121<br />
Dorigo P 83<br />
Dossena M 84, 142<br />
Dossi G 99<br />
Dorent R 121<br />
Dorigo P 83<br />
Dossena M 84, 142<br />
Dossi G 99<br />
Douville K 54<br />
Downey P 76<br />
Drago F 125, 33, 36, 59, 117<br />
Dragoni S 104, 109<br />
Drigo I 110<br />
Ducci E 106<br />
Dunlop J 92<br />
Duran S 99, 100<br />
Duranti A 132<br />
Ean<strong>di</strong> M 104, 106, 111<br />
Eberini I 54<br />
Eboli ML 54<br />
Economidou D 93, 97, 132<br />
Edwards G 97<br />
El Khoury A 85, 118<br />
Emanueli C<br />
Enea D 95<br />
Enrico P 126, 131, 133, 136, 137<br />
Epis R 57, 64, 65, 66, 79, 90,<br />
131<br />
Ercolano E 115<br />
Ercolino SF 79, 102<br />
Ermito S 128<br />
Ernst E 58<br />
Errico S 127<br />
Erriquez J 125<br />
Erzurum S 132<br />
Esposito E 38, 50, 66, 83<br />
Esposito Giovanni 43, 64, 90,<br />
91, 98<br />
Esposito Giuseppe<br />
Etzi R<br />
Eusebi F 88, 114<br />
Eva C 57, 88, 95<br />
Evandri MG 109<br />
Evangelista V 47<br />
Evoli A 45<br />
Evrard A 117<br />
Eyeson J 131<br />
Francini-Pesenti F 107<br />
Fabbri L 32<br />
Fabene PF 146<br />
Fabi F 84<br />
Fabrizi F 142<br />
Facchi A<br />
Facchinetti F 91<br />
Fadda P 30, 130<br />
Failli P 102<br />
Falcone A 59, 80, 81, 138<br />
Falcone D 80<br />
Fallarini S 140<br />
Falzarano S 113<br />
Fanelli R 60<br />
Faniglione M 133<br />
Fanos V 142<br />
Fantin Marianna 61, 78<br />
Fantin Martina<br />
Fanton G 78<br />
Fantozzi R 48, 51, 58<br />
Faraco G 127<br />
Farina C 43<br />
Fascì D 137<br />
Fattore L 30, 31, 130<br />
Faure P 117<br />
Fava G 107, 111<br />
Favari E 121<br />
Fazia ML<br />
Fazio VM 148<br />
Fedele E 82<br />
Fedeli A 93<br />
Femia AP 137<br />
Fenu S 89, 96<br />
Feo C 61<br />
Feo S 138<br />
Ferioli E 121<br />
Ferraguti F 87<br />
Ferrante L 107, 144<br />
Ferranti F 77<br />
Ferranti S 144<br />
Ferrara A<br />
Ferrara N 37<br />
Ferrari A 105, 130<br />
Ferrari D 35<br />
Ferrari M 50, 139, 140, 146<br />
Ferrarini E 113<br />
Ferrario P 83<br />
Ferrari-Toninelli G 65<br />
Ferraro L 31, 65<br />
Ferraro MT 138<br />
Ferraro G 88<br />
Ferreira J 99<br />
Ferreri Ibbadu G 86, 87, 106<br />
Ferrero V 37<br />
Ferretti C 62<br />
Ferretti M 79<br />
Ferri N 121<br />
Ferrieri A 136<br />
Ferrigno A 117<br />
Ferroni S 112<br />
Festa A 99, 100<br />
Festa M 59, 79, 102, 138<br />
Festa R<br />
Fiaschi AI 128, 138<br />
Filaferro M 30, 122<br />
Filigheddu N 136<br />
Filippelli A 29, 37, 43, 47, 107,<br />
120, 128, 144<br />
Filippetti R 122<br />
Filippi S 54<br />
Filippi U 51<br />
Fimognari C 58<br />
Finetti F 101,113<br />
Finicelli M 120<br />
Finocchiaro G 44<br />
Finotti P 37<br />
Fioravanti A 81, 138<br />
Fiorentini A 90, 91, 140<br />
Fioretti MC 51, 55<br />
Fiorito S 120<br />
Fiorucci S 54<br />
Firenzuoli F 107<br />
Fischetti C 78<br />
Fiumara T 54, 101, 120, 136<br />
Flammini L 118<br />
Flan<strong>di</strong>na C 138<br />
Floreani M 61<br />
Florent H<br />
Florio T 79, 90<br />
Flower RJ 102<br />
Foffa I<br />
Fogli E 61, 112, 133<br />
Foglia C 76<br />
Folco G 32, 101, 102, 119<br />
Follesa P 61, 85, 131<br />
Fontaine B 45<br />
Fontanini G 50, 147<br />
Forlani A 50<br />
Formentini L 127<br />
Formisano C 102<br />
Fornai F 45, 97, 126<br />
Fornai M 98, 110, 134<br />
Forni F 31, 125<br />
Forni G 59<br />
Forte A 120<br />
Fortuna A 123<br />
Fossati Giacomo 104, 127<br />
Fossati Gianluca<br />
Fossati S 114, 127<br />
Fournier J 65<br />
Fracasso C<br />
Fracchiolla G 115<br />
Frairia R 104<br />
Franceschelli S 79<br />
Franceschetti S 117<br />
Franceschetti L 113<br />
Franceschi M<br />
Franceschini G 54, 84<br />
Franchi Gian Gabriele 107, 144,<br />
145, 43<br />
Franchi Gianfranco<br />
Franchi S 129, 42, 43, 96<br />
Franchini C 114, 115<br />
Franconi F 100, 123, 140, 39, 57<br />
Frasca A 86<br />
Frasca G 91<br />
Frasson M 37<br />
Frassoni C 117<br />
Fratta W 130, 30, 31, 33, 34,<br />
Fratto V 145, 146<br />
Fratto D 80<br />
Frau L 89<br />
Frau R 94<br />
Fredduzzi S 50<br />
Fre<strong>di</strong>ani S 141<br />
Freeman B 131<br />
Freitas I 117<br />
Fresta M 136<br />
Fresu LG 35<br />
Frigeri A 127<br />
Frigeri C 122<br />
Frigo G 40,98<br />
Frisina N 135, 98<br />
Frol<strong>di</strong> G 81, 83<br />
Frosali S 108, 120, 121<br />
Frosini M 104<br />
Fruttarolo F<br />
Fucile S 88<br />
Fumagalli F 86<br />
Fumagalli M<br />
156
Fumero S 137<br />
Furlanut M 40<br />
Fusco F 142<br />
Fusi F 104<br />
Fuxe K 30, 65<br />
Gabano E 103, 104<br />
Gabbianelli R 108<br />
Gaetani S 31, 125<br />
Gagliani MC 90<br />
Gagliano A 124<br />
Gagliano C 124<br />
Gagliano Maria G<br />
Gagliano M 94, 135<br />
Gagliar<strong>di</strong> S 83<br />
Gaion RM 83, 107, 134<br />
Gala R 126<br />
Galantucci M 117, 126<br />
Galassi G 142<br />
Galderisi U 120<br />
Galdo M 143<br />
Galeotti N 92<br />
Galeotti T 128<br />
Galletta G 123<br />
Galimberti D 135<br />
Gallelli L 80, 105, 106, 132, 142<br />
Gallesi D 105, 139<br />
Galli C<br />
Gallicchio M 48, 58<br />
Gallo M 144<br />
Gallo U 107<br />
Galluzzo M 126<br />
Galvez B<br />
Gandolfi O 123, 132<br />
Garattini S 144<br />
Garau L 86, 126<br />
Gardoni F 65<br />
Gareri P 106<br />
Garibol<strong>di</strong> MB 61, 103<br />
Garrone B 102<br />
Garuana A 130<br />
Garzon G 82<br />
Gasco MR 106, 111<br />
Gasperi V<br />
Gass P 56<br />
Gatta L 92, 129<br />
Gatti M 79<br />
Gatti R 131, 132<br />
Gavioli E 122<br />
Gaviraghi G 46, 92<br />
Gazzerro P 108<br />
Gazzieri D 99, 131<br />
Gebbia N 50, 138<br />
Gelosa P 43, 126<br />
Gelpi G 119<br />
Geminiani E 57, 58, 102<br />
Genazzani AA 62, 104, 115, 125<br />
Genedani S 30<br />
Gennarelli M 85<br />
Genovese R 111<br />
Genovese T 66<br />
Genuini GF 120<br />
Gentile MT 113, 119<br />
Gentile M 111<br />
Gentilella A<br />
Gentilella Raffaella 99, 100, 142<br />
Gentilella Robert<br />
George Alfred L Jr 47<br />
Geppetti P 32, 47, 83, 99, 101,<br />
120, 129, 131, 132<br />
Gerace E<br />
Geraci C 80<br />
Germini G 59<br />
Germanò E 124<br />
Geroni C 61<br />
Gerra G 96<br />
Gertow K 54<br />
Gessa GL 94<br />
Gessi S 37, 61, 112, 133<br />
Ghè C 100, 135, 136<br />
Ghelar<strong>di</strong>ni C 43, 92, 116<br />
Grezzi A<br />
Ghisu N 98, 109, 110, 134<br />
Ghizzar<strong>di</strong> P 134<br />
Giacca M 127<br />
Giaccone G 138, 147<br />
Giachetti A 91, 119<br />
Giachetti D 136<br />
Giaconia L 100<br />
Giagnoni G 61, 129<br />
Giambelli R 85, 118<br />
Giambene B 142<br />
Gianazza E 54<br />
Gianella A 43<br />
Gianfriddo M 61, 92<br />
Gianneli M<br />
Giannini E 50, 92<br />
Giannini L 132<br />
Giannoni P 125<br />
Giannuzzi V 115, 127<br />
Giaquinta G 57, 64, 90<br />
Giar<strong>di</strong>na S 60<br />
Gironi C 98<br />
Gigante B 110<br />
Gillies G<br />
Ginestra G 145<br />
Giordano C 43, 129<br />
Giorgi A 123, 145<br />
Giorgi Filippo<br />
Giorgi Franco 113<br />
Giorgi G 144, 145<br />
Giorgi M 105<br />
Giorgini S 138<br />
Giovannetti A 116<br />
Giovannetti E 103, 147<br />
Giovannini MG<br />
Giovannoni MP 93<br />
Giovinazzo C 144<br />
Giral<strong>di</strong> T 147<br />
Giral<strong>di</strong> P<br />
Giron MC 100, 107, 134<br />
Gironi A 100<br />
Gitto R 87<br />
Giuberti G 128<br />
Giuffrida A 89<br />
Giuffrida ML 116<br />
Giuliani D 53, 54, 98, 117, 126<br />
Giunta M 135<br />
Giuntini S<br />
Giussani L 142<br />
Giusti P 40, 48, 78, 86<br />
Giustini SE 106, 144<br />
Giustino A 36<br />
Gliozzi M 43<br />
Gloaguen I 138<br />
Gnemmi I 104<br />
Gobbi G 118<br />
Gobbi P 115<br />
Goetz I 141<br />
Goffredo D<br />
Gola M 96<br />
Goldberg SR 31, 125<br />
Golia F 142<br />
Golino P 38<br />
Gomaraschi M 54, 84<br />
Gontero P 142<br />
Gori E 97<br />
Gori G 109, 110<br />
Gorini A 89<br />
Gorini G 61, 85, 131<br />
Gorio A 44, 79, 125, 127<br />
Gosmar M 109<br />
Govoni P 137<br />
Govoni S 90, 137<br />
Granata A 121<br />
Grande V 79<br />
Gran<strong>di</strong> D 97<br />
Granito A 99<br />
Granucci F 129<br />
Grassi MC 33, 95<br />
Graziani A 136<br />
Gridelli B 110<br />
Grieco P 53<br />
Grilli M 36, 82<br />
Grimal<strong>di</strong> C 76<br />
Grion AM 107<br />
Grohmann U 55<br />
Grossi C 90, 91<br />
Grossi S 108<br />
Grosso S 110, 139<br />
Gruber S 86<br />
Guaita A 135<br />
Guaita E 98<br />
Gualco A 84<br />
Guaral<strong>di</strong> G 139<br />
Guarini S 37, 53, 54, 101, 117,<br />
126<br />
Guarino I 123<br />
Guarnieri S 62, 79, 112<br />
Guastaferro M<br />
Guasti L 139, 140<br />
Guazzi M 83<br />
Guerriere L 102<br />
Guerrini Remo<br />
Guerrini Renato 78, 93, 97, 98,<br />
114, 122, 132, 135<br />
Guerrini U 126<br />
Guglielmi MD 54<br />
Guglielmotti 102<br />
Guida F 92, 129<br />
Guidali C 31, 61<br />
Guidarelli A<br />
Guidobono F 98<br />
Guidolin D 30, 79<br />
Gulotta G 138<br />
Gunella G 35, 140<br />
Guzzetta M 114<br />
Guzzetti S<br />
Har<strong>di</strong>man G 123<br />
Haro J 141<br />
Harrison S 83, 101, 131<br />
Haycox A 40<br />
Hebbes C 78<br />
Heilig M 132<br />
Heine R 99<br />
Ho L 124<br />
Hoogwerf B 100<br />
Hoozemans J<br />
Hrelia P 58, 88, 147<br />
Hwa J 54<br />
Iacobelli M<br />
Iacono A 50, 83, 100, 128<br />
Iacovelli L 86<br />
Iadarola P 142<br />
Iannone M 87<br />
Iannotti F 81<br />
Iannuccelli V 139<br />
Ibba F 96<br />
Ieri F 140<br />
Iezzi A<br />
157
Iezzi M 59<br />
Illiano M 144<br />
Imbimbo B 91<br />
Imbimbo C 101<br />
Impagnatiello F 90, 102, 114<br />
Imperatore F 120<br />
Impicciatore M 118, 134, 145<br />
Improta G 49, 98, 99, 135<br />
Incorvaia L 138<br />
Infante F 129, 130<br />
Inguglia L 104<br />
Innocenzi A<br />
Invernizzi R 51<br />
Ionta MT<br />
Iori R 108<br />
Ippolito C 98<br />
Isaia E 79<br />
Isola M 130<br />
Iu<strong>di</strong>ce A 146<br />
Iuvone T 43, 90, 91,98 ,137<br />
Jaconi M<br />
Jason S 76<br />
Jensen S 146<br />
John C<br />
Johns Don 99, 100<br />
Johns Don J<br />
Johns J<br />
Juri B 81<br />
Kachare D<br />
Kallupi M 97, 132<br />
Kawase M 109,<br />
Kelsey D 141<br />
Kerbel R 55<br />
Kim Dennis 99, 100<br />
Kim Don<br />
Kim J<br />
Klinge I<br />
Kloting I 122<br />
Klugmann S 54<br />
Koorbanally C<br />
Kostenis E 78<br />
Krankel N<br />
Kroemer G 116<br />
Kuka M 140<br />
Kunic J 47<br />
La Barbera D 131<br />
La Barbera M 94<br />
La Cascia C 131<br />
La Ferla F<br />
La Grutta V 88<br />
La Rana G 42, 50, 128, 129, 136<br />
Labbozzetta M 37, 104, 110<br />
Laghi Pasini F<br />
Laguar<strong>di</strong>a V 111<br />
Lamaida E 129, 130<br />
Lambert DG 114<br />
Lambertucci C<br />
Lampa E 128, 136<br />
Lampus S 106, 147<br />
Lanas A 29<br />
Landucci E 115, 116, 118<br />
Lange DJ 124<br />
Langer F 142<br />
Lanni C 90<br />
Lapi F 107, 143<br />
Lastella M 59, 142, 146, 147<br />
Latorre R 114<br />
Lattanzi R 42, 50, 92<br />
Lattuada D 140<br />
Laus M 103<br />
Lazzari P 104, 121, 125<br />
Lazzeri M 49<br />
Le Fur G 34<br />
Lecca Daniele 96<br />
Lecca Davide 126<br />
Leccese V 96<br />
Lecchini S 50, 98, 139, 140, 145,<br />
146<br />
Ledda F 48, 54, 59<br />
Leggio GM 36, 117<br />
Legnaro M 139, 140<br />
Lembo A 142<br />
Lembo G 113, 119<br />
Lemoli M 94<br />
Lempereur L 81<br />
Lencioni M 59<br />
Lentini G 114<br />
Lenzi M 58<br />
Leon A 91<br />
Leonar<strong>di</strong> P 53<br />
Leone L 84<br />
Leone RL 128<br />
Leoni F 127<br />
Leoni O 143<br />
Leopar<strong>di</strong> G<br />
Lepine A 141<br />
L'Episcopo F 64, 79<br />
Lesma E 79<br />
Leto G 138<br />
Leung E 37, 61, 112<br />
Leurs R 98, 114<br />
Lewis D 141<br />
Li D 132<br />
Liantonio A 47, 114, 115, 127<br />
Licheri GL 147<br />
Ligas F 106<br />
Liguori G 120<br />
Linari G 99, 135<br />
Lintas A 36<br />
Lioi MB 108<br />
Lionetti P 110<br />
Liotti A 105<br />
Lisi I 78<br />
Lisi L 123<br />
Lo VJ<br />
Locatelli V 98, 136<br />
Locchi F 123, 132<br />
Lodovici M 137<br />
Logobar<strong>di</strong> F<br />
Lograno MD 78<br />
Loizzo Alberto 123, 107<br />
Loizzo Annalivia 57, 107<br />
Loizzo S 57, 107, 123<br />
Lombar<strong>di</strong> G 140, 146<br />
Lombardo G 143<br />
Lombardo M 104<br />
Lonati C 53<br />
Longini M 127<br />
Longo A 88<br />
Longo N 101<br />
Lopetuso G 92<br />
Loraschi A 139<br />
Lorenzini P 84<br />
Loriga G 125<br />
Losi G 77, 82<br />
Loupakis F 138<br />
Lourdusamy A 123<br />
Lovaglio S<br />
Lowry JP 36<br />
Lu H 95<br />
Lu J 90<br />
Lubrano C 58, 135<br />
Lucacchini A<br />
Luccarini I 90, 91, 140<br />
Lucchelli A 137<br />
Lucchino I 125<br />
Luccini E 82<br />
Luciani S 78, 117<br />
Lucini V 110, 139<br />
Lucioni C 40<br />
Ludovico GM 142<br />
Luini A 140, 145<br />
Luisi R 81<br />
Lungarella G 101, 131<br />
Luongo L 43<br />
Lupieri T 77<br />
Luppino MR 111<br />
Lutz B 76, 118<br />
Luzi S 131<br />
Lytton J 126<br />
Mac Lennan S 61, 112<br />
Maccari S 56, 123, 126<br />
Maccarrone M 65, 80<br />
Macchi B 116, 142<br />
Macheda T 91, 118<br />
Maciocco E 30, 76, 77<br />
Maclennan S 37<br />
Madaschi L 125<br />
Madeddu P 64<br />
Maestro A 104, 119<br />
Maffei A 113, 119<br />
Maffei F 147<br />
Maggi A 103<br />
Maggi R 125<br />
Maggio R 45, 113<br />
Magi S 31, 115<br />
Magnaghi G 117<br />
Magnaghi V 129<br />
Magnani F 105<br />
Magnelli L 80<br />
Magnotti MC 77<br />
Magrassi R 90<br />
Magri E 146<br />
Mai A 104<br />
Maida S 145, 146<br />
Mainero V 137<br />
Maio RC 139<br />
Maione F 42, 93, 122, 144<br />
Maione S 42, 43, 47, 60, 92, 129<br />
Mairesse J 123, 126<br />
Maiuri MC 111, 116<br />
Maj PF 85<br />
Malinverno M 65<br />
Mallei A 85<br />
Malleo G 138<br />
Malorni W 57<br />
Malusà N 110<br />
Mameli-Engvall M 117<br />
Manca A 79, 90, 94<br />
Manca I 104, 125<br />
Mancar<strong>di</strong> L 82<br />
Manchia M 147<br />
Mancini F 102, 141<br />
Mancini G 76<br />
Mancini M 141<br />
Manconi F 146<br />
Manconi M 129<br />
Mancuso C 127, 128<br />
Mandalari G 145<br />
Manera C 80, 105<br />
Manfre<strong>di</strong> B 48, 83, 121<br />
Manfre<strong>di</strong> L 143<br />
Manfre<strong>di</strong> V 108<br />
Mangano G 102<br />
Mangieri D 127<br />
Mannaioni G 115, 118<br />
Mannaioni PF 80<br />
Mannucci C 95, 130<br />
Manservigi R 146<br />
158
Mantia G 94, 95<br />
Mantovani A 50, 109<br />
Marabese I 92<br />
Marabini L 108<br />
Maranghi F 109<br />
Marasciulo FL 48, 83<br />
Marcellino D 30<br />
Marcello E 65<br />
Marcello S 93<br />
Marchese G 123, 76<br />
Marchesi M 48<br />
Marchetti B 57, 64, 79, 90<br />
Marchetti C 58<br />
Marchetti R 95<br />
Marchi M 36, 82<br />
Marchi S 109, 110<br />
Marcoli M 62, 79, 112<br />
Marconi A 137<br />
Marconi P 146<br />
Marcuzzo S 60<br />
Marelli O 140, 148<br />
Marenzi G 54<br />
Marfella R<br />
Marfia G 125<br />
Margaritis A 108, 120, 121<br />
Margheriti F<br />
Marigliano NM 105, 106<br />
Marilotti L 39<br />
Marinelli A 96<br />
Marini H 58, 101, 135<br />
Marini P 76<br />
Marino Franca 49, 50, 139, 140,<br />
145, 146<br />
Marino Gennaro 113<br />
Marino Laura 84<br />
Marino Marina 110<br />
Marino Sara<br />
Marino Silvia 110, 118<br />
Marinos LM 104<br />
Marinovich M 44<br />
Mariottini C 114<br />
Marongiu C 65, 111<br />
Marotto MF<br />
Marra C 88<br />
Marra R 86, 87, 131<br />
Marras E 61<br />
Marras R 131<br />
Marrelli D 138<br />
Marrocco G 132, 133<br />
Marrosu F 30, 85, 94<br />
Marsicano G 118<br />
Marte A 82<br />
Martelletti P 57, 105<br />
Martelli A 106, 108, 109, 144<br />
Martelossi S 109, 110<br />
Marti M 43, 49<br />
Martignoni E 146<br />
Martinelli M 43<br />
Martinelli V 142<br />
Martini C 43<br />
Martino G 64, 90<br />
Martire A 82<br />
Martire M 81<br />
Martorana A<br />
Martucci D 97<br />
Marzani B 60<br />
Marzatico F 60<br />
Marzocca C 132<br />
Marzocco S 108, 120, 135<br />
Marzola A 146<br />
Marzola E 144<br />
Marzola G 78, 122, 93<br />
Masami K<br />
Masami T 81<br />
Mascagni P 127<br />
Maschi O 145<br />
Mascia MP 76<br />
Mascolo N 122, 144<br />
Maselli MA 135<br />
Maselli R 80<br />
Masi G 56<br />
Masini E 132, 142, 64, 80<br />
Maskos U 30, 117<br />
Masotti G 120<br />
Massa F 76<br />
Massi D 131<br />
Massa E 148<br />
Massa M 49, 51, 122, 132, 93, 97<br />
Massa P 80<br />
Massidda B 50<br />
Mastino A 116<br />
Mastrangelo S 109<br />
Mastrantoni E 77<br />
Mastrogiacomo M 79<br />
Mastroiacovo F<br />
Mastroianni R 80<br />
Mastrotto C 140<br />
Matarrese P 57<br />
Materazzi S 83, 101<br />
Mathé A 86, 118<br />
Matias I 76, 100<br />
Matrisciano F 86, 96<br />
Mattace Raso G 83, 100<br />
Caleo M 81<br />
Matteoli M 81<br />
Matteucci P 123, 126<br />
Matteucci C 116<br />
Mattioli F 106, 108<br />
Matuschak G<br />
Matzeu A 82<br />
Maullu C 65, 111, 148<br />
Maura G 60, 62, 79, 112, 137<br />
Maurici A 37, 104<br />
Mauro A 106<br />
Mazza R 65<br />
Mazzaglia G 39, 40<br />
Mazzola C 36, 125<br />
Mazzon E 38, 65, 66, 103, 133,<br />
137, 138, 145<br />
Mazzoni E 65<br />
Mazzuferi M 146<br />
Mcdonald J 78, 114<br />
Mcgaugh LJ 94<br />
Meda C 57<br />
Medalie J 125<br />
Medhurst A 125<br />
Meini A 78<br />
Mela F<br />
Melani A 28, 61<br />
Melchiorri D 44, 77, 78, 86, 96,<br />
113, 114<br />
Melchiorri P 42, 43, 50, 92<br />
Mele A 114<br />
Mele P 88, 95<br />
Meli R 38, 50, 83, 100, 103, 128,<br />
145<br />
Meli S 80<br />
Melillo G 55, 135, 138<br />
Melis GB 62<br />
Melis MR 101, 130<br />
Melis M 31<br />
Melis T 130<br />
Memo M 41, 65, 124<br />
Mencacci C 28, 66<br />
Menchini Fabris F 142<br />
Mendlewicz J 85<br />
Menegazzi M 145<br />
Meneghelli I 143<br />
Meneguz A 39, 59<br />
Mengozzi G 105<br />
Menna PA 37<br />
Mennini T 60<br />
Merciaro G 84<br />
Mereu GP 94<br />
Mereu M. 131<br />
Merighi S 37, 61, 112, 133<br />
Merlicco A 88<br />
Merlo S 80, 91, 123<br />
Messina S 127<br />
Mey V 103, 147<br />
Mezzetti A<br />
Micale V 36<br />
Miccichè F 91<br />
Miceli F 35<br />
Miceli BG 138<br />
Micheli L 107, 144, 145<br />
Michellson D<br />
Miele E 64<br />
Migheli R 64, 79, 94<br />
Migliar<strong>di</strong> G 124<br />
Miglietta D 119<br />
Miglio GL 146<br />
Migliozzi A 129<br />
Mihm M 99<br />
Milanese M 82<br />
Milano L 124<br />
Milano W 124<br />
Milella M 93<br />
Milton D 100<br />
Minelli A 115<br />
Mini E 50, 55<br />
Miniaci M 55<br />
Minotti G 37<br />
Minutoli L 54, 58, 101, 117, 120,<br />
126, 127, 135, 136<br />
Minutolo A 116<br />
Mioni C 53, 101, 117, 126<br />
Mirabile M 107<br />
Miral<strong>di</strong> E 136<br />
Mirandola P 37, 61, 112<br />
Mirone V 101, 142<br />
Mishra R<br />
Miti<strong>di</strong>eri E 119<br />
Mocaer E<br />
Mochly-Rosen D 55, 80<br />
Modafferi A 94<br />
Modafferi AME 95, 96<br />
Mognetti B 59, 104<br />
Moison D<br />
Moleri E 121<br />
Molin Pradel N<br />
Molinari P 78<br />
Molinaro G 65, 88, 96<br />
Mollace V 44, 84, 93, 128, 146<br />
Molnar J 104, 109<br />
Molteni R 61, 85, 103<br />
Mombelli G 54<br />
Mondaini N 101<br />
Mondelli V 131<br />
Mondello L 146<br />
Mongeau R 93<br />
Monnazzi P 57, 105<br />
Monopoli A 37, 119<br />
Montagnani M 48, 83, 94, 119<br />
Montagnani S 106<br />
Montali M<br />
Montanari C 57, 101, 137<br />
Monteleone P 38<br />
Montesissa C 130<br />
159
Monti E 61, 103<br />
Monti M 118<br />
Monticone M 79<br />
Montinaro E 106<br />
Montopoli M 81, 83<br />
Montorsi F 142<br />
Montuschi P 32<br />
Moore P 48<br />
Moorman A<br />
Morale MC 64, 90<br />
Moran<strong>di</strong> S 95<br />
Morari M 43, 78<br />
Moraschi S 85<br />
Morbidelli L 80, 114, 118, 119,<br />
137<br />
Morelli M 45, 89<br />
Morello S 120, 138<br />
Mores N 127<br />
Moretti S 107, 143<br />
Moretti U 29<br />
Moretto N 91<br />
Morgan C 131<br />
Morgante L 107<br />
Morgese MG 89, 91, 118<br />
Mori M 99<br />
Morigi M 59<br />
Morini G 97, 98<br />
Morley-Fletcher S 123<br />
Moro E 98<br />
Moro S 81<br />
Moroni F 63, 115, 116, 118, 127<br />
Morpurgo M 111<br />
Morreale I 99<br />
Morris J<br />
Morrone LA 65<br />
Morroni F 88<br />
Morsuillo M 107<br />
Mosca F 116<br />
Mosca M 110, 138<br />
Moschini M 29<br />
Mosillo P 77<br />
Mostallino MC 30, 61, 77<br />
Motohashi N 104, 109<br />
Motola D 143<br />
Motolese M 96, 113<br />
Motta A 139<br />
Moulon I 111<br />
Muccioli G 100, 135, 136<br />
Mugelli A 29, 53, 67, 107, 143<br />
Muggironi G<br />
Muià C 38, 66, 103, 133, 138,<br />
145<br />
Mulholland D<br />
Muller C<br />
Muller E<br />
Muntoni AL 31, 95<br />
Muntoni E 106<br />
Muntoni S 88<br />
Mura ML 30, 77<br />
Muraglia M 115<br />
Murgia E 94<br />
Murineddu G 125<br />
Murray RM 131<br />
Murri L 146<br />
Murru L 30, 36, 61, 76, 77, 131<br />
MusanteV 77<br />
Musazzi L 118<br />
Muscatello MR 124<br />
Muscoli C 44, 84, 93, 128<br />
Muscoli S 146<br />
Musiani P 59<br />
Mussa MV 58<br />
Mussoni L 43<br />
Musumeci M 126<br />
Naccari C 144, 145<br />
Nacci C 119<br />
Nannizzi S 147, 103<br />
Nappi G 62, 146<br />
Nassi A 61<br />
Nassini R 83, 101<br />
Nasuti CC 108<br />
Natale G 98, 134<br />
Natale MR<br />
Natali A 101<br />
Nauck MA 99<br />
Nava F 41<br />
Navari S 131<br />
Navarra M 79, 136, 145, 146<br />
Navarra P 123, 136<br />
Navarra T 116<br />
Navarro Mora G 146<br />
Nazzaro C 118, 122<br />
Ndengele M 132<br />
Nebbia C 108<br />
Negri 42, 43, 50, 60, 92, 144<br />
Nencini C 107, 144, 145<br />
Nencini P 86, 93, 95, 96, 97<br />
Neri E 77<br />
Ngomba R 87<br />
Nicchia GP 127<br />
Niccolai N 121<br />
Niccolini C 77<br />
Nico B 127<br />
Nicoletti F 123, 126, 129, 46, 60,<br />
65, 77, 78, 86, 87, 88, 96, 97,<br />
113, 114, 116<br />
Nicoletti P 83, 129<br />
Nicolussi E 50<br />
Niro V<br />
Nisoli E 64<br />
Nisticò G 93<br />
Nisticò S 128<br />
Nistri A<br />
Nistri S<br />
Nizzari M 90<br />
Nobile M 81, 112<br />
Nobili E 43<br />
Norbedo S 110<br />
Norcini M 43, 92<br />
Norppa H 147<br />
Nosi D 125<br />
Notarangelo F 121<br />
Notarbartolo M 37, 104, 110<br />
Noto G 94<br />
Novelli A 63<br />
Novi F<br />
Novick D 141<br />
Nucci C 65<br />
Nunziata A 95<br />
Oberto A 88<br />
Obili N 76<br />
Oddo S 91<br />
Oderda C 137<br />
Oldrini R 98<br />
Olianas MC 86, 126<br />
Olimpieri F 121<br />
Oliva P 84<br />
Oliverio M 93<br />
Olivieri R 119<br />
Olivieri F<br />
Olla A 96<br />
Onali P 58, 65, 86, 111, 126<br />
O'Neill RD<br />
Ongini E 142<br />
Onor ML<br />
Onorati F 120<br />
Opasich F 84<br />
Ori C 107<br />
Oria C 143<br />
Orlan<strong>di</strong> P 81, 138<br />
Orlan<strong>di</strong>ni C 59<br />
Orlando Rocco<br />
Orlando Rosamaria 96, 113, 142<br />
Orlotti D 132, 133<br />
Orrù Marco<br />
Orrù Marisa 94<br />
Orsini F 109<br />
Osella D 103, 104<br />
Otar G<br />
Oteri A 95, 97, 111, 144<br />
Ottani A 126<br />
Pace S 96<br />
Pacifici R 96<br />
Paganelli P 88<br />
Pagetta A 37<br />
Pagotto U 76<br />
Paizis G 136<br />
Palatini P 142<br />
Palazzo E 92, 129<br />
Palleria C 106<br />
Palma E 84, 87,146<br />
Palmi I 97<br />
Palmi M 78<br />
Palomba D 108<br />
Palombo C<br />
Paluzzi P 62, 79, 112,<br />
Paluzzi S 81<br />
Panaccione I 86<br />
Panerai AE 129, 43, 96<br />
Pani G 128,<br />
Pani L 76, 93, 104, 121, 123, 125<br />
Panin F 36<br />
Panini S<br />
Panlilio LV 125<br />
Pannacci M 110, 139<br />
Pantalone D 59<br />
Panuzzo C 140<br />
Panza Elisa 81<br />
Panza L 140<br />
Paoletti T 146<br />
Paoletti AM 62<br />
Paolini M 108, 134<br />
Papaluca Amati M 111<br />
Papi A 133<br />
Papotti M 59<br />
Papparella I 119<br />
Para<strong>di</strong>so B 117, 146<br />
Parati E 60<br />
Par<strong>di</strong>ni C 89<br />
Parente L 55, 59, 64, 79, 102,<br />
138<br />
Parenti A 5, 48, 59<br />
Pariante C 131<br />
Parini F 106<br />
Parolari A 119<br />
Parolaro D 31, 34, 61, 80<br />
Parolini C<br />
Parrinello G 106<br />
Pascale A 98<br />
Pascotto A 35<br />
Pasinetti GM 124<br />
Pasqualetti G 103<br />
Passamonti S 119<br />
Passani MB 114, 125<br />
Pastoris O 84, 99, 142<br />
Pasut G 111<br />
Patacchini R 83, 101, 120<br />
Patacchioli FR 57, 105<br />
Patanè M 114<br />
160
Patrignani P 47, 54, 84, 102<br />
Patrono C 29, 40<br />
Pattarozzi A 79<br />
Patti L 36, 82<br />
Pau A 125<br />
Peana AT 135<br />
Pedata F 35, 60, 61, 113<br />
Peddes C<br />
Pedrazzani C 138<br />
Pedrelli M 121<br />
Pegoraro P 142<br />
Pelaia G 80<br />
Pellegrini-Giampietro D 63, 77,<br />
115, 116, 118<br />
Pelosi V 57, 83<br />
PengoV 107<br />
Pennisi G 81<br />
Pepicelli O 82<br />
Pepponi R<br />
Pergola C 102, 144<br />
Peri F 129<br />
Perletti G 61<br />
Perna F 80<br />
Perra S 31<br />
Perretti M 102<br />
Perrissoud D 136<br />
Perrone S 127<br />
Perrotta C<br />
Perrotta I 126<br />
Perseu MG<br />
Perucca E 30<br />
Perusin M 50<br />
Pessina F 127<br />
Pestarino M 79<br />
Peters GJ 147<br />
Petrella A 59, 138<br />
Petrella Carla 98<br />
Petrella Clau<strong>di</strong>o 124, 135, 93, 99<br />
Petrillo P 43<br />
Petris G 119<br />
Petrò R 76<br />
Petroni A 124<br />
Petroni S<br />
Pezzatini S 118<br />
Pèzzola A 82<br />
Pezzolla F 135<br />
Pfister P 121<br />
Picano E<br />
Piccar<strong>di</strong> MP 46, 147<br />
Piccinin S 114<br />
Piccione F 58<br />
Piccoli A 47<br />
Picerno P 108<br />
Pichini S 97<br />
Picollo A 115<br />
Piegari E 115, 37, 84<br />
Pieratti A 107, 95<br />
Pieretti S 122, 144, 42, 93<br />
Pierno S 115<br />
Pietrini V 91<br />
Pignataro G 126, 63<br />
Pigneri A<br />
Pillolla G 31<br />
Pilloni M<br />
Pilotto A 42<br />
Pincelli C 137<br />
Pinchera A 113<br />
Pinetti D 105, 139<br />
Pini L 129, 92<br />
Pinna A 89<br />
Pinna C 83<br />
Pinna GA 125<br />
Pinna Spada G 123, 76<br />
Pino R<br />
Pinto A 119, 138, 82<br />
Pintor A 82<br />
Piomelli D 129, 132, 34<br />
Pippia P 135<br />
Piras AP 94<br />
Pirozzi Farina F 142<br />
Pirro E 58<br />
Pisa S 130<br />
Pistis M 31, 95<br />
Pistotti V 144<br />
Pisu MG 36, 88, 95<br />
Pittaluga A 44, 77<br />
Pittau B 121<br />
Pitzalis S 111<br />
Pitzianti S 76<br />
Pizza V 129, 130<br />
Plescia F 94, 95<br />
Pluchino S 79, 90<br />
Poggi L 99<br />
Poggiani C 117, 78<br />
Poggioli R 101<br />
Polenzani L 102<br />
Polidori C 122, 97<br />
Polimeni G 111, 144, 29, 99<br />
Polito F 101, 120, 135, 136, 54,<br />
58<br />
Polli F 65<br />
Pollicita M<br />
Poma P 104, 110, 37<br />
Pomelli D<br />
Pompella G<br />
Pons S 117, 30<br />
Pontis S 89<br />
Ponzetto C 136<br />
Popoli P 118, 28, 46, 82<br />
Popolo A 120, 138<br />
Poppi B 130<br />
Porcile C 79<br />
Porcu E 30<br />
Porreca E 54<br />
Porticella E 97<br />
Potenza MA 48, 83<br />
Potenza RL<br />
Potenza S 107<br />
Potì F 121<br />
Poulet R 119<br />
Powell J 131<br />
Pozzesi N 140<br />
Pozzetti L 108<br />
Pozzi E 110<br />
Pozzoli G 123<br />
Presotto C 119<br />
Preti D<br />
Preziosi P 127, 128, 81, 97<br />
Priora R 108, 120, 121<br />
Procacci P 129<br />
Procopio S 136<br />
Proietti F 127<br />
Provenzani A 110<br />
Provenzano GM 94, 95<br />
Puccetti P<br />
Puddu I<br />
Puggioni G 36, 94<br />
Pugliese AM 113, 35<br />
Puia G 77<br />
Pulighe E 135<br />
Pusch M 115<br />
Putzu P 146, 26<br />
Qasem AR 137<br />
Quarto C 120<br />
Quintana H 141<br />
Quintieri L 61<br />
Quon MJ 48<br />
Racagni G 28, 38, 85, 86, 118<br />
Racca S 108<br />
Racchi M 137<br />
Racioppi A 100<br />
Ra<strong>di</strong>ce S 108<br />
Raffa R 88<br />
Raffaeli W 130<br />
Ragazzi E 81<br />
Ragusa S 146<br />
Raiteri L 81, 82<br />
Raiteri M 36, 77, 82<br />
Rammes G 118<br />
Ranzani D 111<br />
Rasini E 50, 139, 140<br />
Ratcliffe M 141<br />
Ravasio G 130<br />
Ravizza R 103, 61<br />
Reali C 85<br />
Reali R 125<br />
Realini N 61<br />
Reggiani A 50, 76<br />
Regoli D 49, 78, 93, 114, 122<br />
Reimondo G 58<br />
Reitano E 44<br />
Remaley A 84<br />
Renda T 80<br />
Rende P 106<br />
Renna G 36<br />
Renzulli A 120<br />
Renzulli M 147<br />
Repetto E 90<br />
Restivo A 93<br />
Ribichini F 37<br />
Riccar<strong>di</strong> C 39, 55, 58, 80, 103,<br />
137, 140<br />
Ricchi L 57, 58, 102<br />
Ricci S 59<br />
Ricciar<strong>di</strong> S 103, 147<br />
Richelmi P 117<br />
Rigamonti AE 135<br />
Rigamonti E 48<br />
Rigatti P 142<br />
Righetti L 125<br />
Rimon<strong>di</strong>ni R 123, 132<br />
Rinal<strong>di</strong> B 37, 47, 107, 120<br />
Rinal<strong>di</strong> M 148<br />
Riozzi B 65, 88, 97<br />
Riva MA 28, 56, 85, 86<br />
Rivas E 96<br />
Rivasi F 31, 125<br />
Rivasi M 79, 101<br />
Rivera M 131<br />
Rizzi A 78, 93, 122<br />
Rizzi M 37<br />
Rizzo G 54<br />
Rizzo M 93<br />
Rizzo V 88, 117<br />
Robbiano L 109<br />
Roberts A 100<br />
Roberts D 30<br />
Robino F 36, 82<br />
Rocca A<br />
Rocchitta G 36, 64, 79, 90, 94<br />
Rodella LF 129<br />
Ro<strong>di</strong> D 122, 146<br />
Ro<strong>di</strong>nò P<br />
Rodolico G 84, 115, 37<br />
Rodriguez J 147<br />
Rodriguez M 59<br />
Roi C 143<br />
Rolf Sprengel 88<br />
Rolland JF 114, 127<br />
161
Romagnino S<br />
Romagnoli P 47<br />
Romani A 140<br />
Romano MR 78<br />
Rombolà L 65<br />
Romeo C 101<br />
Romeo F 146<br />
Romual<strong>di</strong> P 92, 97<br />
Romussi G 144<br />
Roncarati R 92<br />
Ronchetti D 102<br />
Ronchetti F 140<br />
Roozendaal B 94<br />
Rosa AC 58<br />
Rosa P<br />
Rosato A 61<br />
Rosi MC 90<br />
Rossi A 63, 102, 141, 142, 144<br />
Rossi F 32, 37, 38, 43, 47, 52,<br />
84, 92, 120, 129, 132, 133, 144<br />
Rossi G 109<br />
Rossi M 113<br />
Rossi T 103, 139<br />
Rossini C 129<br />
Rossitto A 99<br />
Rossoni G 48, 83, 84, 97, 121<br />
Rotiroti D 84, 87, 93, 128, 146<br />
Rovati G 102, 133<br />
Roviello F 138<br />
Roviezzo F 54, 83, 133<br />
Ruberto A 139<br />
Ruberto G 145<br />
Rubino T 31, 61<br />
Ruco L 138<br />
Ruffilli MP 39, 46<br />
Ruggero G 128<br />
Ruggieri V 92, 122<br />
Ruiu S 125<br />
Runci F 128<br />
Rundle-Smith S 124<br />
Ruozi B 125<br />
Russier J 120<br />
Russo A 111, 144<br />
Russo D 79, 136<br />
Russo E 79, 86, 136<br />
Russo F 142, 144<br />
Russo G 95, 130<br />
Russo M 132, 133<br />
Russo R 42, 44, 50, 128, 129<br />
Russo T 65, 90<br />
Russo E 86, 87, 126<br />
Rustichelli C 121<br />
Saba F 85<br />
Saccani F 118<br />
Sacchetti G<br />
Sacchetto E<br />
Sacchetto V 61, 112, 133<br />
Sacco I 146<br />
Saccomanni G 105<br />
Sacerdote P 42, 43, 49, 96, 129<br />
Saglio G 140<br />
Saija A 128, 144, 145<br />
Sala A 101, 119<br />
Sala M 61, 97<br />
Salani G 90<br />
Salemi M 96<br />
Salis B 65, 111<br />
Salton S 124<br />
Salucci S 115<br />
Salvadori M 137<br />
Salvadori S 93<br />
Salvati P 93<br />
Salvatorelli E 37<br />
Salvemini D 93, 132<br />
Salvetti A 106<br />
Salvo F 95, 99, 143, 144<br />
Sances G 105<br />
Sancesario G<br />
Sancini G 117<br />
Sandrini M 92<br />
Sanguedolce G 138<br />
Sanguedolce R 138<br />
Sani M 104<br />
Sanna A 76, 104<br />
Sanna E 30, 36, 45, 61, 76, 77,<br />
131<br />
Sanna F 101, 130<br />
Santè P 120<br />
Santillo M<br />
Santolini I 87<br />
Santoro A 108<br />
Santoro V 124<br />
Santoru F 88<br />
Sanvito P<br />
Saponara S 104<br />
Sapone A 108<br />
Saporiti F 50<br />
Saramin C 48<br />
Sardo P 88<br />
Sarichelou I 77<br />
Sarnataro D 76<br />
Sarti D 130<br />
Sartiani L 44<br />
Sartori MF 111<br />
Sasso O 42, 50, 128, 129<br />
Satriano C 118<br />
Sautebin L 102, 143, 144<br />
Savani C 43, 90, 91<br />
Saviano R 136<br />
Savica R 107<br />
Savino R 80<br />
Scaccianoce S 86, 94, 95, 96<br />
Scafuro MA 92<br />
Scaglione F 32, 34, 110, 139<br />
Scaldaferri E 48<br />
Scali C 92<br />
Scandroglio P 76<br />
Scaramuzza S 110<br />
Scarcelli C<br />
Scarfone S 87<br />
Scartabelli T 115, 116<br />
Scatigna M 52, 141<br />
Schelling G 94<br />
Schembri L 139, 140<br />
Schenone S 79, 136<br />
Scherma M 31<br />
Schettini G 79, 90<br />
Schiano Moriello A 76<br />
Schiavo G 129<br />
Schiavone S 90<br />
Schiavone N 80<br />
Schillani G 147<br />
Schintu N 89<br />
Schirru C 39, 148<br />
Scholl CA 95<br />
Schrepfer R 111<br />
Schuh K 141<br />
Scicchitano F 86<br />
Sciorati C<br />
Sciulli MG 84<br />
Scorciapino L 85<br />
Scordo MG<br />
Scorziello A 63<br />
Scotto P 136<br />
Scuderi C 43, 90, 91<br />
Scuderi MR<br />
Sculco F 146<br />
Sebastiao AM<br />
Sechi GP<br />
Secondo A 81<br />
Seghieri G 100<br />
Selis F 111<br />
Selvatici R 113<br />
Serafino A 120<br />
Sergi M 111<br />
Serio S 106<br />
Seripa D<br />
Serpe L 104, 111<br />
Serpi A 142<br />
Serra G 57, 94<br />
Serra M 36, 56, 88, 95<br />
Serra 36, 64<br />
Serra V 77<br />
Servid<strong>di</strong>o G 91<br />
Sessa E<br />
Severi P 77<br />
Severino G 147<br />
Sgadò P 89<br />
Sgaragli G 104, 109, 127<br />
Sgaragli T 104<br />
Sgorbini M 105<br />
Sgroi C 111<br />
Sgura A 44<br />
Shah A 104, 109<br />
Shanton F<br />
Shapiro MS 35<br />
Sheen V 90<br />
Sibilia V 98<br />
Sicuteri R 142<br />
Sigala S 106<br />
Signori E 148<br />
Silvestro A 111<br />
Simeon V 111<br />
Simeoni S 57, 105<br />
Simioni C 37, 112, 133<br />
Simola N 89, 96<br />
Simonato M 30, 117, 122, 146<br />
Simoncini T 62<br />
Simoni D 37<br />
Sindona G<br />
Siniscalchi Anna 122<br />
Siniscalchi Antonio 105, 142<br />
Siniscalco D 43, 129<br />
Siracusano MR<br />
Sirca D 131<br />
Sirigu R 85<br />
Sironi L 43, 126<br />
Sirtori C 48, 54<br />
Sitzia F 77<br />
Smid K 147<br />
Smits J 33<br />
Soffia S 78<br />
Sofianos I 36<br />
Soglian A 98<br />
Sogliano C 88<br />
Sogos V 85<br />
Sokolova E<br />
Soldani G 105<br />
Soldovieri MV<br />
Solenghi E<br />
Soleti A 134<br />
Solinas M 31, 125<br />
Solito E 79<br />
Solito R 91, 114<br />
Sollai L 111<br />
Soma R 143<br />
Somaini L 96<br />
Sommer W 132<br />
Sor<strong>di</strong> A 53<br />
162
Sorrentino Raffaella<br />
Sorrentino Rosalinda<br />
Sortino MA 60<br />
Soverchia L 123<br />
Spaccamiglio A 108<br />
Spadaro M 59<br />
Spagnolo B 78, 122<br />
Spampinato S 58, 113, 123, 130,<br />
137<br />
Spampinato U 51<br />
Spano PF 55, 106<br />
Spano MS 30, 130<br />
Sparatore A 48<br />
Sparnacci K 103<br />
Spartà AM<br />
Speciale A 109, 128<br />
Spina O<br />
Spina S<br />
Spina E 30, 107, 124<br />
Spinsanti P 65, 78<br />
Spinzia C 128<br />
Spisani S 113<br />
Sportiello L 143<br />
Sprio AE 58<br />
Squadrito F 54, 58, 101, 117,<br />
120, 126, 127, 135, 136<br />
Squassina A 146, 147<br />
Stark H 98<br />
Starowicz K 76, 100<br />
Stasi MA 86<br />
Steardo L 43, 90, 91, 98<br />
Stein EA<br />
Stephan H<br />
Sternieri E 105, 130<br />
Sternini C 135<br />
Steven C 81<br />
Sticozzi C 78<br />
Stillitano F<br />
Stocco A 107<br />
Stocco G 109, 110<br />
Stocchino ME<br />
Stopponi S 97, 132<br />
Storm-Mathisen J<br />
Storto M 88, 97<br />
Straface E 57<br />
Straub RH<br />
Stroik J 31<br />
Strongoli C<br />
Strongoli MC 87<br />
Suarez D 141<br />
Succu S 101, 130<br />
Suffre<strong>di</strong>ni S<br />
Sullo N 110, 132, 133, 139<br />
Sumberaz A 108<br />
Summa D 108, 120, 121<br />
Sumner C 141<br />
Sutton V 141<br />
Suzuki H<br />
Svensson HT<br />
Tabrizi MA 89<br />
Tabucchi A 117<br />
Tacchetti C 90<br />
Tacchi R 31, 125,<br />
Tacchi S 125<br />
Tacconelli S 54, 84, 102<br />
Taglialatela M 35, 37, 45, 81<br />
Talani G 36, 77<br />
Tambaro S 121<br />
Tamborra R 91<br />
Tamburella A 117<br />
Tamiazzo L 136<br />
Tammaro E 124<br />
Tanda G 86<br />
Tanganelli S<br />
Tani C 110<br />
Tanzarella C<br />
Tar<strong>di</strong>to D 118, 85<br />
Tari M 143<br />
Tari U 143<br />
Tarozzi A 88<br />
Tarquini E 137<br />
Tarquinio M 48, 119<br />
Tarzia G 132<br />
Tascedda F 62, 85<br />
Tasdemir E 116<br />
Tatarelli R 86<br />
Taylor G 65, 110, 111<br />
Tazzari V 48<br />
Tebano MT 82<br />
Tedesco M 130<br />
Tekle C 147<br />
Temperilli F 95<br />
Terdoslavich M 119<br />
Teresa M 118<br />
Terragna C 147<br />
Terrazzani G 48<br />
Terstappen G 92<br />
Terzolo M 58<br />
Terzuoli E 113<br />
Tesi F 100<br />
Testa M 142<br />
Testa N 57, 64, 90<br />
Testino G 108<br />
Thellung S 79<br />
Thiemermann C 48, 133<br />
Thorsten B<br />
Tiraboschi E 85<br />
Tirolo C 90<br />
Tita B 104<br />
Togna AR 120<br />
Togna G 96<br />
Tognolini 134<br />
Tolu S 30<br />
Tomaino A 109, 144<br />
Tomasini MC 65<br />
Tommasini I<br />
Tonacchera M 113<br />
Tonachini L 79<br />
Tonazzini I<br />
Tonini A 132<br />
Tonini M 42, 60, 99, 133, 135<br />
Tonini S 133<br />
Tonon G 65, 111, 148<br />
Torres Y 114<br />
Torsello A 136<br />
Torta R 66<br />
Tortiglione A 126<br />
Tortorella P 115<br />
Tortorella V 114<br />
Toscano A 116<br />
Tosco A 59<br />
Tosi A 112, 133<br />
Tosi G 31, 125<br />
Totani L 47<br />
Tozzi M 139<br />
Trabace L 57, 90, 91<br />
Traficante A 65<br />
Traini C 113<br />
Tramentozzi E 37<br />
Trapella C 78<br />
Trautman M 99<br />
Traversa S 137<br />
Trefiletti G 96<br />
Tremoli E 38, 43, 53, 54, 119,<br />
126<br />
Trevisani M 99, 120, 129, 131,<br />
132<br />
Trevisi L 78<br />
Trezza V 31, 94<br />
Tricarico D 45<br />
Trifirò G 124, 143<br />
Trimarco B 110<br />
Trimarco V 110<br />
Trincavelli ML 35<br />
Tringali G 123, 136<br />
Triolo F 110<br />
Trisolini P 135<br />
Trombetta D 145<br />
Tronci E 89<br />
Trovato AE 129<br />
Tucci P 57<br />
Tuccori M 29, 143, 144<br />
Tumminello FM 138<br />
Turriziani M 104<br />
Ubal<strong>di</strong> M 123<br />
Uberti D 65<br />
Uccelli A 82<br />
Uliva C 132, 142<br />
Ullu LM 86<br />
Uras Roberta 77<br />
Ursino MG 134<br />
Usai C 82<br />
Uvec Group 143<br />
Uziel G 124<br />
Uzzo M 119<br />
Vacca F<br />
Vaglini F 89<br />
Vago T 119<br />
Vairetti M 117<br />
Valenti LP 106<br />
Valenti M 80<br />
Valenti S 104<br />
Valentini V 86, 96<br />
Valeri A 127<br />
Valle G 60<br />
Valoti M 104, 109<br />
Valsecchi AE 129<br />
Valsecchi V 126<br />
Valtancoli B 102<br />
Van Gaal LF 99<br />
Van Luijtelaar G 87<br />
Vanacore N 107<br />
Vandelli MA 31, 125<br />
Vanderschuren LJMJ 31<br />
Vannacci A 29, 107, 143<br />
Vannucchi MG 61<br />
Varani K 28, 37, 61, 112, 133<br />
Varano E 136<br />
Vargiu G 136<br />
Varoni MV 108<br />
Vasina V 134<br />
Vassanelli C 37<br />
Vecchio I 87, 128<br />
Vecchione C 113<br />
Vegeto E 57, 103<br />
Velar<strong>di</strong> E 58, 80, 137<br />
Vella S 39, 46, 52<br />
Vellecco V 54, 83, 133<br />
Venco A 139, 140<br />
Vendemiale G 91<br />
Venezia V 90<br />
Ventrice D<br />
Ventura A 109, 110<br />
Verderio C 35, 81<br />
Vergoni AV 31, 125<br />
Vergura R 93<br />
Veronese F 111<br />
Verri M 84, 142, 99<br />
163
Vetrice D 93, 128<br />
Vettorato E 130<br />
Vezzalini F 137<br />
Viaggi C 89<br />
Viano I 57, 104<br />
Viaro R 43<br />
Viganò D 31, 61<br />
Vighi E 99<br />
Viglio S 142<br />
Villa G<br />
Villa LM 146<br />
Villa R 130<br />
Villa RF 89<br />
Villa V 79<br />
Villarosa F 95<br />
Villetti G 91<br />
Vincenzi F 112, 133<br />
Vinci MC 48, 54, 59<br />
Vinci S 96, 130<br />
Viola S 80<br />
Vir<strong>di</strong>s A 134<br />
Vir<strong>di</strong>s F 131<br />
Visalli V 84, 128, 146<br />
Vita D 92<br />
Vita G 127<br />
Vitale G 92, 122<br />
Vitali F 104<br />
Vitellaro-Zuccarelli L 102<br />
Vitelli MR 84, 37<br />
Vitiello M 102<br />
Vitti P 113<br />
Viviani B 44<br />
Vivoli E 43, 92, 116<br />
Vizzini G 110<br />
Volonté C 35<br />
Volonterio A 121<br />
Volpe AR 60, 109<br />
Volpe Giampiero 129, 130<br />
Volpe Gisellla 140<br />
Volpi I 146<br />
Volpini R 35<br />
Volta R 91<br />
Volta U 99<br />
Volterra A<br />
Wang J 124<br />
Wang ZQ 66<br />
Warne J<br />
Weksler BB 54<br />
Wertheim CE 31<br />
Widel MH<br />
Wilson S<br />
Wotjak CT 47<br />
Wren P<br />
Yasar S 125<br />
Yemul S 124<br />
Zaccheddu R 36<br />
Zafar B<br />
Zaffani S 107<br />
Zaffaroni M 50<br />
Zaffe D 117, 126<br />
Zaggia B 58<br />
Zagli G 83, 120, 129<br />
Zagotto G 81<br />
Zambon A 40<br />
Zambrano N 65<br />
Zanda M 104, 121<br />
Zanelli U 92<br />
Zanetti E 98<br />
Zangla A 111<br />
Zani A 61, 97<br />
Zaninetti R 125<br />
Zanoli P 57, 101, 137<br />
Zanotti I 121<br />
Zappettini Simona<br />
Zappettini Stefania 36, 81, 82<br />
Zara G 104, 106, 111<br />
Zavatti M 57, 101, 137<br />
Zecchi S 131<br />
Zeppegno P 35<br />
Zhang J 66<br />
Zhao Z 124<br />
Ziche M 55, 80, 91, 101, 113,<br />
114, 118, 119, 137<br />
Zieglgansberger W 118<br />
Zinellu A 57<br />
Zinman B 100<br />
Zoccali R 124<br />
Zoja C 43<br />
Zonca A 130<br />
Zonta F 117<br />
Zoppellaro C 134<br />
Zotti M 123<br />
Zucca S<br />
Zuccaro P 97<br />
Zucchini S 117, 122, 146<br />
Zuccotti A 137<br />
Zuddas A 56<br />
Zuena AR<br />
Zupi G 138<br />
Zusso M 78, 86<br />
164
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