Versione completa in PDF - SIF - Università degli Studi di Torino
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PATROCINI<br />
CONTRIBUTI<br />
Regione Autonoma<br />
Friuli-Venezia Giulia<br />
Prov<strong>in</strong>cia <strong>di</strong> Trieste<br />
Comune <strong>di</strong> Trieste<br />
M<strong>in</strong>istero della Salute<br />
SISSA – Scuola Internazionale Superiore <strong>di</strong><br />
<strong>Stu<strong>di</strong></strong> Avanzati, Trieste<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Trieste<br />
Facoltà <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Chirurgia dell’<strong>Università</strong><br />
<strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Trieste<br />
Facoltà <strong>di</strong> Farmacia dell’<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />
<strong>di</strong> Trieste<br />
Facoltà <strong>di</strong> Psicologia dell’<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />
<strong>di</strong> Trieste<br />
Facoltà <strong>di</strong> Scienze Matematiche, Fisiche e<br />
Naturali dell’<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Trieste<br />
Ord<strong>in</strong>e Nazionale dei Biologi<br />
Ord<strong>in</strong>e dei Me<strong>di</strong>ci Chirurghi e <strong>degli</strong><br />
Odontoiatri della Prov<strong>in</strong>cia <strong>di</strong> Trieste<br />
Ord<strong>in</strong>e dei Farmacisti della Prov<strong>in</strong>cia<br />
<strong>di</strong> Trieste<br />
Consiglio Regionale dell’Ord<strong>in</strong>e <strong>degli</strong> Psicologi<br />
del Friuli-Venezia Giulia<br />
Società Italiana <strong>di</strong> Chemioterapia<br />
Società Italiana <strong>di</strong> Tossicologia<br />
A.I.O.M. – Associazione Italiana Oncologia<br />
Me<strong>di</strong>ca<br />
Piaceri Senza Conf<strong>in</strong>i – Regione Autonoma Friuli-Venezia Giulia<br />
SISSA – Scuola Internazionale Superiore <strong>di</strong> <strong>Stu<strong>di</strong></strong> Avanzati, Trieste<br />
Consorzio per lo Sviluppo Internazionale<br />
dell’<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Trieste<br />
Assicurazioni Generali SpA<br />
A.I.A.T. – Agenzia <strong>di</strong> Informazione e <strong>di</strong> Accoglienza Turistica, Trieste
31° CONGRESSO NAZIONALE<br />
DELLA SOCIETÀ ITALIANA DI FARMACOLOGIA<br />
Trieste<br />
26-29 giugno 2003<br />
COORDINATORI DEL CONGRESSO<br />
Tullio Giral<strong>di</strong><br />
Andrea Nistri<br />
COMITATO COORDINATORE LOCALE<br />
Fiora Bartoli<br />
Giuliana Decorti<br />
Gianfranco Guarnieri<br />
Anton<strong>in</strong>o Gullo<br />
Giorgio Mustacchi<br />
Gianni Sava<br />
Ugo Traversa<br />
Alessandro Ventura<br />
COMITATO SCIENTIFICO<br />
Pier Luigi Canonico (Novara)<br />
Achille Caputi (Mess<strong>in</strong>a)<br />
Michele Carruba (Milano)<br />
V<strong>in</strong>cenzo Cuomo (Roma)<br />
Mario Del Tacca (Pisa)<br />
Walter Fratta (Cagliari)<br />
Giovanni Gaviraghi (Siena)<br />
Mario Marchi (Genova)<br />
Alessandro Mugelli (Firenze)<br />
Giancarlo Pepeu (Firenze)<br />
Carlo Riccar<strong>di</strong> (Perugia)<br />
Gennaro Schett<strong>in</strong>i (Genova)<br />
SEGRETERIA SCIENTIFICA<br />
Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che,<br />
<strong>Università</strong> <strong>di</strong> Trieste<br />
Via Licio Giorgieri 7, 34127 Trieste<br />
Tel. 040 5583537 Fax 040 577435<br />
E-mail: sif2003@units.it<br />
CONGRESSO ON-LINE:<br />
Sito Internet della Società Italiana <strong>di</strong><br />
Farmacologia<br />
http://farmacologiasif.unito.it<br />
E-mail: sif@unito.it<br />
SEGRETERIA ORGANIZZATIVA<br />
Key Congressi<br />
Piazza della Borsa 7, 34121 Trieste<br />
Tel. 040 660352<br />
Fax 040 660353<br />
congressi@keycongressi.it<br />
www.keycongressi.it<br />
SEGRETERIA AMMINISTRATIVA<br />
Progetti <strong>di</strong> Congress <strong>Stu<strong>di</strong></strong>o<br />
P.le Stefano Türr 5, 20149 MILANO<br />
Tel. 02 3196951<br />
Fax 02 33604939<br />
<strong>in</strong>fo@congress-stu<strong>di</strong>o.it<br />
www.congress-stu<strong>di</strong>o.it
INFORMAZIONI SCIENTIFICHE<br />
Riassunti dei poster e delle comunicazioni orali<br />
I contributi accettati verranno messi <strong>in</strong> rete nel sito<br />
Web della <strong>SIF</strong> e <strong>in</strong>clusi nel libro <strong>degli</strong> abstracts del<br />
Congresso.<br />
Comunicazioni orali<br />
Le comunicazioni orali, sud<strong>di</strong>vise per tema, avranno la<br />
durata <strong>di</strong> 15 m<strong>in</strong>uti, <strong>in</strong>clusa la <strong>di</strong>scussione (12+3 m<strong>in</strong>uti).<br />
Si raccomanda la scrupolosa osservanza<br />
del tempo a <strong>di</strong>sposizione per ciascuna comunicazione.<br />
Poster<br />
I poster, sud<strong>di</strong>visi per tema, avranno a <strong>di</strong>sposizione<br />
uno spazio <strong>di</strong> cm 70 <strong>di</strong> larghezza e cm 120 <strong>di</strong> altezza.<br />
L’affissione e la rimozione dovranno avvenire rigorosamente<br />
all’<strong>in</strong>izio e alla f<strong>in</strong>e della giornata prevista per la<br />
loro presentazione nel programma. È richiesta la presenza<br />
presso ciascun poster <strong>di</strong> un Autore durante il periodo<br />
della visione e <strong>di</strong>scussione dei poster.<br />
Supporti au<strong>di</strong>ovisivi<br />
Saranno a <strong>di</strong>sposizione dei relatori i seguenti sistemi <strong>di</strong><br />
proiezione:<br />
• Videoproiezione da PC con programma Power<br />
Po<strong>in</strong>t (Office 2000)<br />
• Lavagna lum<strong>in</strong>osa<br />
I CD-Rom od i luci<strong>di</strong>, con l’<strong>in</strong><strong>di</strong>cazione dell’Autore e<br />
sessione, dovranno essere consegnati al Centro au<strong>di</strong>ovisivi<br />
almeno un’ora prima dell’<strong>in</strong>izio della Sessione.<br />
INFORMAZIONI GENERALI<br />
La segreteria Organizzativa e quella Commerciale<br />
saranno attive nella Sede del Congresso dalle ore<br />
10.00 <strong>di</strong> giovedì 26 giugno 2003.<br />
Segreteria della <strong>SIF</strong><br />
La Segreteria della <strong>SIF</strong> sarà operativa presso la Sede<br />
del Congresso<br />
dalle ore 10.00 <strong>di</strong> giovedì 26 giugno 2003.<br />
QUOTE <strong>di</strong> ISCRIZIONE Dal<br />
(Iva 20% <strong>in</strong>clusa) 1/4/2003<br />
Soci <strong>SIF</strong> Ä 370<br />
Non soci <strong>SIF</strong> Ä 450<br />
Partecipanti non strutturati<br />
<strong>di</strong> età <strong>in</strong>feriore a 35 anni * Gratuita<br />
Cena Sociale** Ä 50 a persona<br />
* alla scheda <strong>di</strong> iscrizione verrà allegata copia <strong>di</strong> un documento<br />
<strong>di</strong> identità ed una <strong>di</strong>chiarazione del responsabile<br />
della struttura dove viene prestato servizio.<br />
** La cena prevede un massimo <strong>di</strong> 300 persone. Pertanto<br />
le richieste verranno considerate <strong>in</strong> base all’ord<strong>in</strong>e<br />
<strong>di</strong> ricevimento.<br />
Attestato <strong>di</strong> partecipazione<br />
A tutti gli iscritti al Congresso verrà<br />
rilasciato dalla Segreteria Organizzativa, su<br />
richiesta, un attestato <strong>di</strong> partecipazione.<br />
Mostra tecnico-scientifica<br />
Presso la sede del Congresso sarà presente<br />
un’esposizione <strong>di</strong> Aziende, prodotti e<br />
servizi <strong>di</strong> <strong>in</strong>teresse per i partecipanti.<br />
Internet (Congresso on-l<strong>in</strong>e)<br />
Informazioni aggiuntive ed aggiornate sul<br />
Congresso sono reperibili nella sezione<br />
Congresso on-l<strong>in</strong>e del sito Internet della <strong>SIF</strong>,<br />
all’<strong>in</strong><strong>di</strong>rizzo<br />
http://farmacologiasif.unito.it/.<br />
Tutti i contributi accettati per la<br />
presentazione dal Comitato Scientifico<br />
saranno pubblicati su Internet, da cui<br />
potranno essere agevolmente scaricati <strong>in</strong><br />
un formato adatto anche alla stampa.<br />
Cre<strong>di</strong>ti ECM<br />
Me<strong>di</strong>ci, farmacisti, biologi e psicologi<br />
partecipanti al Congresso e regolarmente<br />
iscritti potranno ottenere cre<strong>di</strong>ti ECM,<br />
secondo le modalità che saranno <strong>in</strong><strong>di</strong>cate<br />
nella sezione Congresso on-l<strong>in</strong>e del sito<br />
Internet della <strong>SIF</strong>.<br />
Programma sociale<br />
per gli accompagnatori<br />
È previsto un programma sociale per gli<br />
accompagnatori, i cui dettagli saranno<br />
<strong>di</strong>sponibili sul sito Web del Congresso<br />
on-l<strong>in</strong>e e presso la Segreteria Organizzativa<br />
durante il Congresso.<br />
L’iscrizione dà <strong>di</strong>ritto a:<br />
• Partecipazione ai lavori<br />
• Kit congressuale<br />
• Volume del programma e dei riassunti<br />
• Attestato <strong>di</strong> partecipazione<br />
• Cocktail <strong>di</strong> benvenuto<br />
• Coffee breaks<br />
• Colazioni <strong>di</strong> lavoro
Giovedì 26 giugno<br />
10.00 - 18.00 Registrazione dei partecipanti<br />
AULA MAGNA<br />
14.00 Apertura del Congresso<br />
15.00 Lettura Magistrale<br />
Dalla genetica alla terapia<br />
EDOARDO BONCINELLI<br />
Introduce: FRANCESCO CLEMENTI<br />
16.00 M<strong>in</strong>isimposio<br />
La farmacologia italiana<br />
<strong>di</strong> fronte alle nuove<br />
<strong>di</strong>sposizioni regolatorie<br />
FILIPPO DRAGO<br />
GIANNI BENZI<br />
18.00 Lettura Magistrale<br />
Endocannab<strong>in</strong>oi<strong>di</strong>:<br />
logica molecolare<br />
e potenziale terapeutico<br />
DANIELE PIOMELLI<br />
Introduce: GIANLUIGI GESSA<br />
AULA 0B<br />
AULA 1A<br />
AULA 1B<br />
Comunicazioni orali Comunicazioni orali Comunicazioni orali<br />
Neurofarmacologia Neurofarmacologia: Neurofarmacologia:<br />
malattie<br />
neurodegenerative<br />
cannab<strong>in</strong>oi<strong>di</strong>
Venerdì 27 giugno<br />
AULA MAGNA<br />
8.30 M<strong>in</strong>isimposio<br />
Aspetti farmacologici<br />
dei chemioterapici <strong>in</strong>ibitori<br />
<strong>di</strong> oncogeni ad attività<br />
tiros<strong>in</strong>o-ch<strong>in</strong>asica<br />
MARIO DEL TACCA<br />
ENRICO MINI<br />
10.30 Coffee break<br />
11.00 M<strong>in</strong>isimposio<br />
Farmaci antitumorali selettivi<br />
e nuovi farmaci citotossici:<br />
promesse che saranno<br />
mantenute ?<br />
TERESITA MAZZEI<br />
ROMANO DANESI<br />
16.00 M<strong>in</strong>isimposio<br />
Farmacologia del dolore<br />
cronico: prospettive future<br />
ANGELO REGGIANI<br />
LUCIA NEGRI<br />
18.30 Simposio satellite<br />
Escitalopram: l’<strong>in</strong>novazione<br />
attraverso l’evoluzione<br />
GIORGIO RACAGNI<br />
FILIPPO DRAGO<br />
AULA 0B<br />
Comunicazioni orali<br />
Neurofarmacologia:<br />
pur<strong>in</strong>e<br />
Comunicazioni orali<br />
Neuropsicofarmacologia<br />
Comunicazioni orali<br />
Farmacologia<br />
car<strong>di</strong>ovascolare I<br />
AULA 1A<br />
M<strong>in</strong>isimposio<br />
Sostanze <strong>di</strong> abuso<br />
e sviluppo del<br />
sistema nervoso<br />
VINCENZO CUOMO<br />
ENRICO ALLEVA<br />
M<strong>in</strong>isimposio<br />
Recettori nativi<br />
per il glutammato:<br />
implicazioni <strong>in</strong><br />
fisiologia e patologia<br />
FERDINANDO NICOLETTI<br />
MAURIZIO RAITERI<br />
13.00 AULA MAGNA Assemblea della Sezione <strong>di</strong> Farmacologia Cl<strong>in</strong>ica della <strong>SIF</strong><br />
13.00 Colazione <strong>di</strong> lavoro<br />
14.00 Visione e <strong>di</strong>scussione dei posters<br />
18.00 Coffee break<br />
20.30 Cena Sociale<br />
Comunicazioni orali<br />
Neurofarmacologia:<br />
danno ischemico<br />
AULA 1B<br />
Comunicazioni orali<br />
Farmacologia della<br />
muscolatura liscia<br />
Comunicazioni orali<br />
Farmacologia cl<strong>in</strong>ica<br />
Comunicazioni orali<br />
Chemioterapia I
Sabato 28 giugno<br />
AULA MAGNA<br />
8.30 M<strong>in</strong>isimposio<br />
Meccanismi trasduzionali<br />
e trascrizionali nell’azione<br />
dei farmaci antidepressivi<br />
ed antipsicotici<br />
NICOLETTA BRUNELLO<br />
GIORGIO RACAGNI<br />
10.30 Coffee break<br />
11.00 M<strong>in</strong>isimposio<br />
S.I.F. – L.I.C.E. Onlus<br />
Verso farmaci antiepilettici<br />
<strong>di</strong> terza generazione<br />
EMILIO PERUCCA<br />
GIULIANO AVANZINI<br />
13.00 Colazione <strong>di</strong> lavoro<br />
14.00 Visione e <strong>di</strong>scussione dei posters<br />
16.00 M<strong>in</strong>isimposio<br />
Regolazione delle funzioni<br />
gastro<strong>in</strong>test<strong>in</strong>ali: prospettive<br />
per nuove terapie<br />
farmacologiche<br />
MARIO DEL TACCA<br />
MARCELLO TONINI<br />
AULA 0B<br />
Comunicazioni orali<br />
Farmacologia delle<br />
funzioni <strong>di</strong>gestive<br />
e respiratorie<br />
AULA 1A<br />
M<strong>in</strong>isimposio<br />
Rischio<br />
car<strong>di</strong>ovascolare:<br />
meccanismi <strong>di</strong> danno<br />
e protezione<br />
FABRIZIO LEDDA<br />
AMELIA FILIPPELLI<br />
AULA 1B<br />
Comunicazioni orali M<strong>in</strong>isimposio M<strong>in</strong>isimposio<br />
Immunofarmacologia La placca aterosclero- Nuove prospettive<br />
tica <strong>in</strong>stabile: mecca- farmacologiche<br />
nismi cellulari, mole- <strong>di</strong> terapia nelle<br />
colari e modulazione tossico<strong>di</strong>pendenze<br />
farmacologica GIANLUIGI GESSA<br />
FRANCESCO ROSSI<br />
RODOLFO PAOLETTI<br />
WALTER FRATTA<br />
M<strong>in</strong>isimposio<br />
Il crav<strong>in</strong>g:<br />
dalla neurologia<br />
alla terapia<br />
GAETANO DI CHIARA<br />
Comunicazioni orali M<strong>in</strong>isimposio M<strong>in</strong>isimposio<br />
Chemioterapia II La farmacologia dei Malattie<br />
PUFA n-3: dall’igloo neurodegenerative:<br />
al laboratorio alla meccanismi<br />
pratica cl<strong>in</strong>ica patogenetici<br />
Coord<strong>in</strong>atore: e farmaci<br />
ALESSANDRO MUGELLI GIANCARLO PEPEU<br />
RODOLFO PAOLETTI<br />
ALDO PIETRO MAGGIONI<br />
ENNIO ONGINI<br />
18.00 AULA MAGNA Assemblea generale della Società Italiana <strong>di</strong> Farmacologia
Domenica 29 giugno<br />
AULA MAGNA<br />
8.30 M<strong>in</strong>isimposio<br />
Meccanismi molecolari e<br />
cellulari del danno cerebrale<br />
ischemico: nuove prospettive<br />
terapeutiche<br />
FLAVIO MORONI<br />
LUCIO ANNUNZIATO<br />
10.30 Coffee break<br />
AULA 0B<br />
Comunicazioni orali<br />
Tossicologia<br />
11.00 M<strong>in</strong>isimposio<br />
Comunicazioni orali<br />
Analogie molecolari nei Farmacologia<br />
processi <strong>di</strong> sviluppo neuronale<br />
e <strong>di</strong> neurodegenerazione:<br />
nuove prospettive<br />
farmacologiche ?<br />
PIERLUIGI CANONICO<br />
MAURIZIO MEMO<br />
car<strong>di</strong>ovascolare II<br />
13.00 AULA MAGNA Chiusura del Congresso<br />
AULA 1A<br />
M<strong>in</strong>isimposio<br />
Determ<strong>in</strong>anti genetici<br />
e molecolari della<br />
risposta <strong>in</strong><strong>di</strong>viduale<br />
agli <strong>in</strong>ibitori delle<br />
ciclo-ossigenasi<br />
CARLO PATRONO<br />
MARIO DEL TACCA<br />
M<strong>in</strong>isimposio<br />
Farmacoeconomia<br />
ADRIANA CECI<br />
LUCIANO CAPRINO<br />
AULA 1B<br />
Comunicazioni orali<br />
Chemioterapia III<br />
Comunicazioni orali<br />
Farmacologia<br />
dell’<strong>in</strong>fiammazione
Assemblea Generale<br />
della Società Italiana<br />
<strong>di</strong> Farmacologia<br />
Aula Magna della Palazz<strong>in</strong>a H3. Comprensorio Universitario <strong>di</strong><br />
Piazzale Europa.<br />
Venerdì 27 giugno 2003 alle ore 21.00 <strong>in</strong> prima convocazione<br />
Sabato 28 giugno 2003 alle ore 18.00 <strong>in</strong> seconda convocazione<br />
per <strong>di</strong>scutere e deliberare sul seguente ord<strong>in</strong>e del giorno:<br />
1. Relazione sull’attività del Consiglio Direttivo (V<strong>in</strong>cenzo Cuomo)<br />
2. Cerimonia <strong>di</strong> consegna dei seguenti Premi:<br />
•10 Premi Farm<strong>in</strong>dustria – <strong>SIF</strong><br />
•Premio Associazione Simonetta Nicosia<br />
3. Relazione del Collegio dei Revisori e approvazione del bilancio<br />
consuntivo 01/01/2002-31/12/2002<br />
4. Approvazione del bilancio preventivo 2003<br />
5. Ammissione Nuovi Soci<br />
6. Varie ed eventuali<br />
7. Elezione del Presidente<br />
8. Elezione del Consiglio Direttivo<br />
9. Elezione della Commissione per l’Ammissione dei Nuovi Soci<br />
10. Elezione dei Revisori dei Conti<br />
Le schede elettorali saranno <strong>di</strong>stribuite presso la segreteria<br />
organizzativa della <strong>SIF</strong><br />
a partire dalle ore 9.00 <strong>di</strong> venerdì 27 f<strong>in</strong>o alle ore 14.30 <strong>di</strong><br />
sabato 28 giugno.<br />
I soci sono pregati <strong>di</strong> attenersi a questo orario.
COME RAGGIUNGERE<br />
LA SEDE CONGRESSUALE<br />
In Automobile<br />
Strada alta (generalmente meno congestionata)<br />
Giungendo dalla A4 Tor<strong>in</strong>o-Trieste,<br />
lasciare l’Autostrada <strong>in</strong> corrispondenza<br />
dell’uscita “PROSECCO - Trieste Centro”;<br />
proseguire qu<strong>in</strong><strong>di</strong> per Villa Opic<strong>in</strong>a e poi<br />
per Trieste Centro. Seguire le <strong>in</strong><strong>di</strong>cazioni<br />
per l’<strong>Università</strong>.<br />
Strada bassa (panoramica, ma congestionata<br />
nei weekend e d’estate).<br />
Giungendo dalla A4 Tor<strong>in</strong>o-Trieste,<br />
lasciare l’Autostrada <strong>in</strong> corrispondenza<br />
dell’uscita “Sistiana - Trieste Centro”;<br />
proseguire qu<strong>in</strong><strong>di</strong> lungo la SS14 adriatica<br />
f<strong>in</strong>o al centro Città. Arrivati alla stazione<br />
ferroviaria proseguire per via Milano e<br />
qu<strong>in</strong><strong>di</strong> per l’<strong>Università</strong>.<br />
In Aereo<br />
Dall’aeroporto del Friuli-Venezia Giulia a<br />
Ronchi dei Legionari, utilizzare i Pullman<br />
Alitalia a <strong>di</strong>sposizione per raggiungere la<br />
Stazione ferroviaria <strong>di</strong> Trieste.<br />
Dall’aeroporto <strong>in</strong>ternazionale Venezia<br />
Marco Polo utilizzare il servizio <strong>di</strong> autobus<br />
<strong>di</strong> l<strong>in</strong>ea (tempo <strong>di</strong> passaggio me<strong>di</strong>o 20<br />
m<strong>in</strong>uti) per raggiungere la stazione<br />
ferroviaria <strong>di</strong> Venezia-Mestre e qu<strong>in</strong><strong>di</strong> la<br />
Stazione ferroviaria <strong>di</strong> Trieste.<br />
Prendere l’Autobus numero 17/ oppure il<br />
taxi f<strong>in</strong>o a Piazzale Europa 1.<br />
In Treno<br />
Da Venezia-Mestre raggiungere la Stazione<br />
ferroviaria <strong>di</strong> Trieste.<br />
Prendere l’Autobus numero 17/ oppure il<br />
taxi f<strong>in</strong>o a Piazzale Europa 1.<br />
31° CONGRESSO<br />
NAZIONALE<br />
DELLA SOCIETÀ ITALIANA<br />
DI FARMACOLOGIA<br />
Trieste<br />
26-29 giugno 2003<br />
COMPRENSORIO<br />
UNIVERSITARIO<br />
Palazz<strong>in</strong>a H3<br />
sede del Congresso<br />
PARCHEGGIO<br />
Vi ricor<strong>di</strong>amo che non è possibile parcheggiare<br />
all’<strong>in</strong>terno dell’<strong>Università</strong>.<br />
Bisognerà servirsi <strong>di</strong> un limitato numero<br />
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In Autobus<br />
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l<strong>in</strong>ea 17/ Stazione centrale (lato Ghega) - San Cil<strong>in</strong>o<br />
l<strong>in</strong>ea 39 Stazione centrale (lato Ghega) - Villa Opic<strong>in</strong>a<br />
l<strong>in</strong>ea 51 Stazione centrale (lato Ghega) - Basovizza - Area<br />
<strong>di</strong> Ricerca o Pese.<br />
Il biglietto <strong>di</strong> corsa semplice costa 0,95 E.<br />
Ulteriori <strong>in</strong>formazioni su www.triestetrasporti.it
note
La Società Italiana <strong>di</strong> Farmacologia<br />
ed il Comitato Organizzatore esprimono<br />
il più vivo r<strong>in</strong>graziamento a:<br />
A.C.R.A.F. Azienda Chimiche Riunite Angel<strong>in</strong>i Francesco S.p.A.<br />
Actimex srl<br />
AstraZeneca S.p.A.<br />
Aventis Pharma S.p.A.<br />
Bayer S.p.A.<br />
Fournier Pharma S.p.A.<br />
Innova Pharma S.p.A.<br />
Janssen-Cilag S.p.A.<br />
Lundbeck Italia S.p.A.<br />
Merck Sharp & Dohme S.p.A.<br />
L. Molteni Farmaceutici & C. dei F.lli Alitti S.p.A.<br />
Novartis Farma S.p.A.<br />
Pfizer Italia S.r.l.<br />
Pharmacia Italia S.p.A.<br />
Scher<strong>in</strong>g-Plough S.p.A.<br />
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.<br />
SPA-Società Prodotti Antibiotici S.p.A.<br />
il loro r<strong>in</strong>graziamento a:<br />
Abiogen Pharma S.p.A.<br />
Biome<strong>di</strong>ca Mangoni snc<br />
Charles River Laboratoires Italia S.p.A.<br />
Data Sciences<br />
Eli Lilly Italia S.p.A.<br />
ETI S.p.A. Centro Ricerche Napoli<br />
GlaxoSmithKl<strong>in</strong>e UK, the Neurology & GI Centre<br />
of Excellence for Drug Discovery<br />
Harlan Italy S.r.l.<br />
Nicox<br />
Nikem Research S.rl.l<br />
Recordati Industria Chimica e Farmaceutica S.p.A.<br />
Tecniplast<br />
Ugo Basile S.r.l.<br />
Valeas S.p.A.<br />
V<strong>in</strong>ci-Biochem<br />
Zambon Italia S.r.l.<br />
Z-Cube S.p.A.<br />
<strong>Stu<strong>di</strong></strong>o Grafico N<strong>in</strong>o Bon – Trieste
GIOVEDI’ 26 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 14.00 – 19.00<br />
14.00 APERTURA DEL CONGRESSO E SALUTO AI PARTECIPANTI<br />
Interventi delle Autorità<br />
15.00 LETTURA MAGISTRALE:<br />
E. Bonc<strong>in</strong>elli (Trieste)<br />
Dalla genetica alla terapia.<br />
Introduce: F. Clementi (Milano)<br />
MINISIMPOSIO: La farmacologia italiana <strong>di</strong> fronte alle nuove <strong>di</strong>sposizioni regolatorie.<br />
Moderatori: F. Drago (Catania) - G. Benzi (Pavia)<br />
16.00 L’omogenizzazione delle <strong>di</strong>sposizioni regolatorie <strong>in</strong> Europa<br />
V. Sabat<strong>in</strong>i (Roma)<br />
16.20 La <strong>di</strong>rettiva europea sulla farmacovigilanza.<br />
F. Drago (Catania)<br />
16.40 La sperimentazione cl<strong>in</strong>ica dei me<strong>di</strong>c<strong>in</strong>ali: la nuova <strong>di</strong>rettiva europea.<br />
C. Tom<strong>in</strong>o (Roma)<br />
17.00 La legislazione europea <strong>in</strong> materia <strong>di</strong> farmaci orfani.<br />
G. Benzi (Pavia)<br />
17.20 La normativa europea <strong>in</strong> materia <strong>di</strong> <strong>in</strong>tegratori alimentari ed il suo recepimento <strong>in</strong> Italia.<br />
M. Carruba (Milano)<br />
17.40 How far are we from the European regulatory community?<br />
C. Sampaio (Lisboa)<br />
18.00 LETTURA MAGISTRALE:<br />
D. Piomelli (Irv<strong>in</strong>e, CA)<br />
Endocannab<strong>in</strong>oi<strong>di</strong>: logica molecolare e potenziale terapeutico.<br />
Introduce: G.L. Gessa (Cagliari)<br />
1
GIOVEDI’ 26 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 16.00 – 18.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Neurofarmacologia<br />
Moderatori: F. Cattabeni (Milano) – M. Taglialatela (Napoli)<br />
Ore Abs. book<br />
page<br />
16.00 TEMPORAL RESOLUTION OF ENDOGENOUS BDNF SECRETION DURING<br />
LONG TERM SYNAPTIC POTENTIATION AND DEPRESSION IN THE RAT<br />
PERIRHINAL CORTEX<br />
Argilli E. °, Cappello S*, Aicar<strong>di</strong> G. °, Bovara M*, Canossa M*<br />
*Dept. of Pharmacology, University of Bologna, via Irnerio 48, 40126 Bologna, Italy;<br />
°Dept. of Physiology, University of Bologna, via Irnerio 50, Bologna, Italy<br />
16.15 ENDOGENOUS SEROTONIN REDUCES HIPPOCAMPAL EXCITATORY<br />
SYNAPTIC TRANSMISSION BY PREFERENTIAL ACTIVATION OF 5-HT1B<br />
RECEPTORS LOCATED ON CA1 PYRAMIDAL NEURONES<br />
Corradetti R., Ml<strong>in</strong>ar B.<br />
Dipartimento <strong>di</strong> Farmacologia Precl<strong>in</strong>ica e Cl<strong>in</strong>ica, <strong>Università</strong> <strong>di</strong> Firenze, V.le G.<br />
Pieracc<strong>in</strong>i 6, 50139 Firenze, Italia<br />
16.30 EFFECTS OF BACLOFEN ON DIZOCILPINE-MEDIATED DISRUPTION OF<br />
PREPULSE INHIBITION<br />
Bortolato M., Frau R., Aru G.N., Orrù M., Gessa G.L.<br />
Department of Neuroscience “Bernard B. Bro<strong>di</strong>e”; Center of Excellence<br />
“Neurobiology of dependence”, University of Cagliari<br />
16.45 PHARMACOLOGICAL PROPERTIES OF RENAL CLC-K CHLORIDE<br />
CHANNELS HETEROLOGOUSLY EXPRESSED WITH BARTTIN REVEALED<br />
BY THE USE OF 2-(p-CHLOROPHENOXY)PROPIONIC ACID DERIVATIVES<br />
1 Liantonio A., 2 Picollo A., 2 Elia L., 2 Traverso S., 1 Didonna M., 1 De Luca A., 1<br />
Pierno S., 3 Loio<strong>di</strong>ce F., 3 Tortorella P., 3 Fracchiolla G., 3 Bonerba E., 2 Pusch M., 1<br />
Conte Camer<strong>in</strong>o D.<br />
1. Unit of Pharmacology, Dept. of Pharmacobiology, Univ. of Bari; 2. Institute of<br />
Biophysic-CNR, Genova; 3. Dept. of Me<strong>di</strong>c<strong>in</strong>al Chemistry, Univ. of Bari.<br />
17.00 AN EMOTIONAL MEMORY PARADIGM INCREASES ACETYLCHOLINE<br />
RELEASE AND ACTIVATES ERK PATHWAY IN THE MEDIAL PREFRONTAL<br />
CORTEX AND VENTRAL HIPPOCAMPUS OF THE RAT<br />
Giovann<strong>in</strong>i M.G., Pazzagli M., Malmberg-Aiello P., Rakovska A. *, Parsi S., Della<br />
Corte L., Pepeu G.<br />
Dip. Farmacologia, <strong>Università</strong> <strong>di</strong> Firenze, Viale Pieracc<strong>in</strong>i 6, 50139 Firenze, Italia<br />
and * Inst. Physiology, Bulgarian Acad. Sci., Sofia, Bulgaria<br />
2<br />
4<br />
37<br />
15<br />
78<br />
69
Ore Abs. book<br />
page<br />
17.15 INTERLEUKIN-1b ENHANCES NMDA RECEPTOR-MEDIATED<br />
INTRACELLULAR CALCIUM INCREASE THROUGH ACTIVATION OF THE<br />
Src FAMILY OF KINASES<br />
Mar<strong>in</strong>ovich M., Viviani B., Bartesaghi S., Gardoni F. °, Vezzani A. *, Behrens M. §,<br />
B<strong>in</strong>aglia M., Cors<strong>in</strong>i E., Di Luca M. °, Galli C.L..<br />
Lab. Toxicology and °Center of Excellence on Neurodegenerative Diseases, Dept. of<br />
Pharmacol. Sci., Milan, Italy; * Mario Negri Inst., Milan, Italy; § The Scripps Res.<br />
Inst., La Jolla, USA<br />
17.30 ROLE OF THE TRANSCRIPTION FACTOR NRSF/REST IN NEURONAL<br />
DIFFERENTIATION<br />
Di Toro R., Spamp<strong>in</strong>ato S.<br />
Department of Pharmacology, University of Bologna, Irnerio 48, 40126 Bologna,<br />
Italy<br />
17.45 TOPIRAMATE MODULATION OF THE SLOW POST-STIMULUS<br />
AFTERHYPERPOLARIZING TAIL CURRENT (IAHP) DEPENDS ON CALCIUM<br />
ENTRY VIA L-TYPE CALCIUM CHANNELS IN RAT OLFACTORY<br />
CORTICAL NEURONES IN VITRO<br />
*Constanti A., § Russo E.<br />
*Pharmacology Department, School of Pharmacy, University of London, England,<br />
UK. § Cattedra <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale e Cl<strong>in</strong>ica,<br />
<strong>Università</strong> “Magna Graecia” Catanzaro, Italia<br />
3<br />
85<br />
50<br />
36
GIOVEDI’ 26 GIUGNO<br />
_______________________________________________________________________AULA 1A<br />
Ore 16.00 – 18.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Neurofarmacologia: malattie neurodegenerative<br />
Moderatori: P.A. Borea (Ferrara) – M.P. Abbracchio (Milano)<br />
Ore Abs. book<br />
page<br />
16.00 ADENOSINE A2A RECEPTORS EXERT A FACILITATORY/PERMISSIVE ROLE<br />
ON METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5)-MEDIATED<br />
EFFECTS IN THE RAT STRIATUM.<br />
Domenici M.R., Pepponi R, Potenza RL, Tebano M.T., Popoli P.<br />
Pharmacology Department, Istituto Superiore <strong>di</strong> Sanità, Viale Reg<strong>in</strong>a Elena 299,<br />
00161 Rome, Italy.<br />
16.15 ESTROGEN NEUROPROTECTION IN 1-METHYL-l-4-PHENYL-1,2,3,6-<br />
TETRAHYDRO-PYRIDINE (MPTP) MODEL OF PARKINSON’S DISEASE IS<br />
MEDIATED BY NEURON-ASTROCYTE-MICROGLIA CROSSTALK<br />
*Morale MC, °Serra P-A, *Tirolo C,*Caniglia S, *Testa N, *L'Episcopo F, *Gennuso<br />
F, °DeLogu MR, °Rocchitta G, °Migheli R, §Scoto G, °Miele E, °Desole MS,<br />
*°Marchetti B.<br />
*Neuropharmacology, OASI, Tro<strong>in</strong>a (EN) 94018 Tro<strong>in</strong>a, Italy, ° Dept. Pharmacol.<br />
Univ of Sassari and §Dept. Pharmacology, Fac. Pharmacy, University of Catania,<br />
Italy.<br />
16.30 NEUROSTEROIDOGENIC PATHWAYS TOWARD RETINAL<br />
NEURODEGENERATION OR NEUROPROTECTION<br />
Cascio C. 1 * , Guarneri R. 1 , Russo D. 1 , Drago G. 1 , D’ Agost<strong>in</strong>o S. 1 , Galizzi G. 1 ,<br />
De Leo G. 2 , Guarneri M. 4 , Piccoli F. 3 , Guarneri P. 1<br />
1 2<br />
Istituto <strong>di</strong> Biome<strong>di</strong>c<strong>in</strong>a e Immunologia Molecolare, C.N.R, Palermo; Dip. <strong>di</strong><br />
Biopatologia e Metodologie Biome<strong>di</strong>che, 3 Ist. Neuropsichiatria, 4 Facoltà <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a<br />
e Chirurgia, Univ. Palermo, Italy<br />
16.45 THROMBIN INDUCES RAT ASTROCYTES PROLIFERATION AND LEADS TO<br />
THE INTERACTION BETWEEN TYROSINE PHOSPHORYLATED C-<br />
TERMINAL FRAGMENTS OF APP AND SHC/GRB2 ADAPTORS<br />
Salis S., Russo C., Dolc<strong>in</strong>i V., Venezia V., Repetto E., Genova F., Nizzari M.,<br />
Schett<strong>in</strong>i G.<br />
Pharmacology and Neuroscience National Cancer Institute (IST) c/o Advanced<br />
Biotechnology Center and Section of Pharmacology Dept. of Oncology, Biology and<br />
Genetics Univ. of Genova, Largo Rosanna Benzi, 10-16132 Genoa, Italy<br />
17.00 CONFORMATION DEPENDENT ASTROGLIAL AND NEURONAL EFFECTS<br />
OF THE RECOMBINANT HUMAN PRION FRAGMENT PRP 90-231<br />
Corsaro A. 1 , Villa V. 1 , Aceto A. 2 , Palu<strong>di</strong> D. 2 , Rossi Pr<strong>in</strong>cipe D. 2 , Schett<strong>in</strong>i G. 1 ,<br />
Florio T. 1<br />
1 Section of Pharmacology DOBIG Univ. of Genova and Pharmacology and<br />
Neuroscience, IST Genova, Italy; 2 Section of Biochemistry, Dept. Biome<strong>di</strong>cal<br />
Sciences, University G. D’Annunzio, Chieti, Italy<br />
4<br />
51<br />
96<br />
26<br />
124<br />
38
Ore Abs. book<br />
page<br />
17.15 CHOLINE ESTERS POTENTIATE EEG EFFECTS AND IMPROVEMENT OF<br />
COGNITIVE FUNCTIONS PRODUCED BY TACRINE IN ANIMAL MODELS<br />
OF ALZHEIMER’S DISEASE<br />
1 Rispoli V., 3 Marra R., 2 Scipione L., 1 Rotiroti D., 2 Liberatore F., 2 Carelli V.<br />
1 Department of Pharmacobiological Sciences, University of Catanzaro “Magna<br />
Græcia”; 2 Department of Chemistry and Technology of Biologically Active<br />
Substances, University of Rome “La Sapienza”; 3 CNR Institute of Neurological<br />
Sciences, Catanzaro, Italy<br />
17.30 BRAIN NEUROPATHOLOGY AND CHOLINERGIC MECHANISMS IN A<br />
MODEL OF ALZHEIMER DISEASE: TgCNRD8 MICE<br />
Scali C., Prosperi C., Bellucci A., Giovann<strong>in</strong>i M.G., Luceri C., St. George-Hyslop<br />
P.*, Pepeu G., Casamenti F.<br />
Department of Pharmacology, University of Florence, Florence Italy and *Centre for<br />
Research <strong>in</strong> Neurodegenerative Disease, University of Toronto, Toronto Canada<br />
17.45 THE ROLE OF ENDOGENOUS MELATONIN IN THE STRIATAL<br />
ANTIOXIDANT POOL. A MICRODIALYSIS STUDY IN PC12 CELLS IN VITRO<br />
AND IN THE STRIATUM OF FREELY MOVING RATS IN VIVO<br />
Pier Andrea Serra, Gaia Rocchitta, Maria R. Delogu, Rossana Migheli, Maria G.<br />
Taras, Maria P. Mura, Giovanni Esposito, Egi<strong>di</strong>o Miele, Maria S. Desole<br />
Department of Pharmacology, University of Sassari, 07100 Sassari<br />
5<br />
118<br />
126<br />
128
GIOVEDI’ 26 GIUGNO<br />
_______________________________________________________________________AULA 1B<br />
Ore 16.00 – 18.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Neurofarmacologia: cannab<strong>in</strong>oi<strong>di</strong><br />
Moderatori: A. Panerai (Milano) – P. Nenc<strong>in</strong>i (Roma)<br />
Ore Abs. book<br />
page<br />
16.00 ANANDAMIDE MAY NOT AFFECT HIPPOCAMPAL CA1 LONG-TERM<br />
POTENTIATION THROUGH CHANGES OF SYNAPTIC PLASTICITY<br />
Diana G., Valent<strong>in</strong>i G., Libran<strong>di</strong> D., Loizzo A.<br />
Drug Department, Istituto Superiore <strong>di</strong> Sanità, Viale Reg<strong>in</strong>a Elena 299 - 00161 Roma<br />
16.15 THE AMNESIC EFFECTS INDUCED BY b-AMYLOID RELATED PEPTIDES<br />
INVOLVE CANNABINOID NEUROTRANSMISSION IN THE BRAIN<br />
Mazzola C., Micale V., Consoli D., Drago F.<br />
Department of Experimental and Cl<strong>in</strong>ical Pharmacology, University of Catania<br />
Me<strong>di</strong>cal School, Viale A. Doria 6, 95125 Catania, Italy<br />
16.30 NEUROFUNCTIONAL CONSEQUENCES OF PRENATAL CANNABINOID<br />
EXPOSURE IN RATS<br />
Tattoli M. 1 , Cagiano R. 1 , Mereu G. 2 Ferraro L. 3 , Antonelli T. 3 , Ghiglieri V. 2 ,<br />
Tanganelli S. 3 , Gessa G.L. 2 , V. Cuomo 4 .<br />
1 Dept. of Pharmacology and Human Physiology, University of Bari,<br />
6<br />
2 Dept. of<br />
Experimental Biology, University of Cagliari, 3 Dept. of Cl<strong>in</strong>ical and Experimental<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Ferrara, 4 Dept. of Pharmacology and General Physiology,<br />
University “ La Sapienza” Rome<br />
16.45 CB1 RECEPTORS ARE INVOLVED IN THE ANTIHYPERALGESIC ACTIVITY<br />
OF CANNABINOIDS IN A MODEL OF NEUROPATHIC PAIN<br />
Calignano A.*, La Rana G.*, Russo R. *, Piomelli D. §<br />
*Dept. of Experimental Pharmacology, Faculty of Pharmacy, via D. Montesano 49<br />
Naples, Italy. § Dept. of Pharmacology, 360 MSR II, University of California, Irv<strong>in</strong>e,<br />
CA92697-4625, USA<br />
17.00 SHORT-AND LONG-TERM EFFECTS ON CORTICAL GLUTAMATE RELEASE<br />
INDUCED BY PRENATAL EXPOSURE TO THE CB1 RECEPTOR AGONIST<br />
WIN55212-2<br />
Ferraro L., Tanganelli S. 1 , Tomas<strong>in</strong>i M.C. 1 , Bebe B.W. 1 , Steardo L. 2 , Sab<strong>in</strong>o V.<br />
2 ,Carratu M.R. 3 , Cuomo V. 4 , Antonelli T. 1<br />
1 Dep. Cl<strong>in</strong>. Exp. Me<strong>di</strong>c<strong>in</strong>e, Univ. of Ferrara, Italy; 2 Dep. Pharmacol. Sciences, Univ.<br />
of Palermo, Italy; 3 Dep. Pharmacol. and Human Physiol., Univ. of Bari, Italy; 4 Dep.<br />
Pharmacol. and Gen. Physiol., Univ. “La Sapienza” Roma, Italy<br />
17.15 MODULATION OF ENDOCANNABINOID LEVELS IN MORPHINE<br />
DEPENDENCE<br />
Viganò D. 1 , Di Marzo V. 2 , Rub<strong>in</strong>o T. 1 , Valenti M. 2 Parolaro D. 1<br />
1 DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria,<br />
Busto Arsizio (VA); 2 Endocannab<strong>in</strong>oid Research Group, Istituto <strong>di</strong> Chimica<br />
Biomolecolare, CNR, Pozzuoli (NA), Italy<br />
46<br />
90<br />
136<br />
21<br />
57<br />
144
Ore Abs. book<br />
page<br />
17.30 ROLE OF OLEYLETHANOLAMIDE IN THE REGULATION OF FEEDING<br />
BEHAVIOR<br />
Gaetani S. 1 # , Fu J. 1 , Oveisi F. 1 , Rodríguez de Fonseca F.*, Cuomo V. # Piomelli D.<br />
1<br />
1 Dept. of Pharmacology, University of California, Irv<strong>in</strong>e CA-USA; * Fundación<br />
Hospital Carlos Haya, 29010 Málaga, Spa<strong>in</strong>; # Dip. <strong>di</strong> Farmacologia delle Sostanze<br />
Naturali e Fisiologia Generale, Fac. <strong>di</strong> Farmacia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Roma “La<br />
Sapienza”<br />
17.45 CANNABINOID MODULATION OF RAT PINEAL ACTIVITY: IN VITRO AND<br />
IN VIVO EVIDENCE<br />
L. Steardo 1 , M. Dalle Carbonare 2 , P. Monteleone 4 , A. Busalacchi 1 , P. Cottone 1<br />
, M. Valenti 1 -5 , D. Arci<strong>di</strong>acono 1 -2 ; V. Cuomo 3 , A. Leon 2 , M. Maj 4 , V. Di Marzo<br />
5<br />
.<br />
1 2<br />
Dept of Pharmacological Sciences, University of Palermo, Italy; Research &<br />
Innovation Company, Padova, Italy; 3 Dept. of Pharmacology of Natural Substances<br />
and General Physiology, University of Rome La Sapienza, Italy; 4 Institute of<br />
Psychiatry, University of Naples SUN, Naples; 5 CNR Pozzuoli, Naples, Italy<br />
7<br />
62<br />
133
VENERDI’ 27 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 8.30-10.30<br />
MINISIMPOSIO: Aspetti farmacologici dei chemioterapici <strong>in</strong>ibitori <strong>di</strong> oncogeni ad attività<br />
tiros<strong>in</strong>o-ch<strong>in</strong>asica.<br />
Moderatori: M. Del Tacca (Pisa) – E. M<strong>in</strong>i (Firenze)<br />
In collaborazione con la Società Italiana <strong>di</strong> Chemioterapia<br />
8.30 Ruolo <strong>di</strong> oncogeni ad attività tiros<strong>in</strong>o-ch<strong>in</strong>asica nel processo <strong>di</strong> trasformazione neoplastica.<br />
A. Greco (Milano)<br />
8.50 Farmacologia e farmacogenetica <strong>degli</strong> <strong>in</strong>ibitori <strong>di</strong> oncogeni ad attività tiros<strong>in</strong>o-ch<strong>in</strong>asica.<br />
R. Danesi (Pisa)<br />
9.10 Aspetti cl<strong>in</strong>ici e terapeutici delle neoplasie stromali gastro<strong>in</strong>test<strong>in</strong>ali con attivazione <strong>di</strong> ckit.<br />
F. De Braud (Milano)<br />
9.30 Il ruolo <strong>di</strong> bcr-abl nelle s<strong>in</strong>dromi mieloproliferative e prospettive terapeutiche con <strong>in</strong>ibitori<br />
farmacologici.<br />
G. Rosti (Bologna)<br />
9.50 Prospettive <strong>di</strong> sviluppo <strong>di</strong> nuovi farmaci <strong>in</strong>ibitori <strong>di</strong> oncogeni ad attività tiros<strong>in</strong>o-ch<strong>in</strong>asica.<br />
D. Alberti (Origgio)<br />
8
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 8.30 – 10.30<br />
SESSIONE DI COMUNICAZIONI ORALI: Neurofarmacologia: Pur<strong>in</strong>e<br />
Moderatori: U. Traversa (Trieste) – F. Caciagli (Chieti)<br />
Ore Abs. book<br />
page<br />
8.30 ACTIVATION OF ADENOSINE A1 AND GLUTAMATE mGLU3<br />
METABOTROPIC RECEPTORS PROTECT CULTURED ASTROCYTES FROM<br />
STAUROSPORINE-INDUCED APOPTOSIS<br />
1 Bruno V., 2 Santavenere C., 2 Vis<strong>in</strong>i D., 2 D’Alimonte I., 2 Patricelli P., 2 Giuliani<br />
P., 1 Nicoletti F., 2 Caciagli F., 2 Di Iorio P., 2 Ciccarelli R.<br />
1 Dept. of Pharmacology and Physiology, University of Rome “La Sapienza”, Rome,<br />
Italy. 2 Dept. of Biome<strong>di</strong>cal Sciences, “G. D’Annunzio” University, Chieti, Italy<br />
8.45 CASPASE-2 IS UPSTREAM OF CASPASE-3 IN THE APOPTOSIS INDUCED BY<br />
2-CHLORO-2’-DEOXY-ADENOSINE (CLADRIBINE) AND 2-CHLORO-<br />
ADENOSINE IN HUMAN ASTROCYTOMA CELLS<br />
Ceruti S.*, Beltrami E.*, Matarrese P.#, Mazzola A.*, Cattabeni F.*, Malorni W.#,<br />
Abbracchio M.P.*<br />
*Dipartimento <strong>di</strong> Scienze Farmacologiche-Facoltà <strong>di</strong> Farmacia-<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />
<strong>di</strong> Milano-MILANO; #Dipartimento <strong>di</strong> Ultrastrutture-Istituto Superiore <strong>di</strong> Sanità-<br />
ROMA<br />
9.00 EXPRESSION OF FUNCTIONAL A3 ADENOSINE RECEPTORS IN HUMAN<br />
LYMPHOCYTES<br />
1 Gessi S., 1 Varani K., 1 Merighi S., 1 Cattabriga E., 1 Avitabile A., 2 Gavioli R., 2<br />
Cannella A, 2 Fort<strong>in</strong>i C., 3 Leung E., 1 Pancal<strong>di</strong> C., 1 Iannotta V., 1 Borea P.A.<br />
1 2<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Pharmacology Unit and<br />
Department of Biochemistry and Molecular Biology, University of Ferrara, Italy; 3<br />
K<strong>in</strong>g Pharmaceutical Research, Research Triangle Park, North Carol<strong>in</strong>a<br />
9.15 ROLE OF A1, A2A AND A3 ADENOSINE RECEPTORS IN ISCHEMIC<br />
PRECONDITIONING IN THE RAT HIPPOCAMPUS IN VITRO<br />
A.M. Pugliese, R. Corradetti, F. Pedata<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, University of Florence,Viale<br />
Pieracc<strong>in</strong>i 6, 50139 Firenze, Italy<br />
9.30 THE P2 PURINOCEPTOR ANTAGONIST BASILEN BLUE PROTECTS FROM<br />
BRAIN DAMAGE AND NEUROLOGICAL DEFICIT INDUCED BY<br />
PERMANENT FOCAL CEREBRAL ISCHEMIA IN THE RAT<br />
Melani A., Gianfriddo M, Vannucchi M.G.*, Volontè C.**, Sancesario G.***,<br />
Pedata F.<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, University of Florence,<br />
Florence; *Department of Histology, University of Florence, Florence;**Institute of<br />
Neurobiology and Molecular Me<strong>di</strong>c<strong>in</strong>e, Rome;***Department of Neuroscience,<br />
University of Tor Vergata, Rome<br />
9<br />
17<br />
31<br />
67<br />
114<br />
90
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9.45 A NEW RECEPTOR FOR GUANOSINE IS COUPLED TO THE MODULATION<br />
OF ADENYLATE CYCLASE AND MAP KINASE ACTIVITIES IN PRIMARY<br />
CULTURES OF RAT ASTROCYTES<br />
Traversa U., Bombi G., Palmieri C.<br />
Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, <strong>Università</strong> <strong>di</strong> Trieste; via L. Giorgieri 7, 34127<br />
Trieste<br />
10.00 ATP RELEASED FROM ASTROCYTES INDUCES VESICLES SHEDDING AND<br />
IL-1beta RELEASE FROM ADJACENT MICROGLIA CELLS<br />
Verderio C 1 , Bianco F. 1 , Pravettoni E. 1 , Schenk U. 1 , Matteoli M. 1 ,2 .<br />
1 2<br />
CNR-Institute of Neuroscience and Department of Me<strong>di</strong>cal Pharmacology,<br />
University of Milano, 20129 Milano, Italy<br />
10.15 PHOSPHODIESTERASE INHIBITORS AFFECT NITROBENZYLTHIOINOSINE<br />
(NBTI)-SENSITIVE (es) AND NBTI-INSENSITIVE (ei) NUCLEOSIDE<br />
TRANSPORTERS IN PC12 CELLS<br />
Florio C, Vadori M, Righetto V., Gaion RM*<br />
Department of Biome<strong>di</strong>cal Sciences, University of Trieste and *Department of<br />
Pharmacology and Anaesthesiology, University of Padova<br />
10<br />
139<br />
144<br />
58
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 1A<br />
Ore 8.30 – 10.30<br />
MINISIMPOSIO: Sostanze <strong>di</strong> abuso e sviluppo del sistema nervoso<br />
Moderatori: V. Cuomo (Roma) – E. Alleva (Roma)<br />
8.30 S<strong>in</strong>drome alcolica fetale: caratteristiche e meccanismi.<br />
L.G. Costa (Bari)<br />
9.00 Cannab<strong>in</strong>oi<strong>di</strong> e ontogenesi del SNC: aspetti molecolari e neurofunzionali.<br />
S. Tanganelli (Ferrara)<br />
9.30 Comportamenti a rischio e risposta a psicostimolanti <strong>in</strong> ro<strong>di</strong>tori adolescenti.<br />
G. Laviola (Roma)<br />
10.00 La miel<strong>in</strong>izzazione: bersaglio <strong>di</strong> costituenti del fumo <strong>di</strong> sigaretta?<br />
M.R. Carratù (Bari)<br />
11
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 1B<br />
Ore 8.30 – 10.30<br />
SESSIONE DI COMUNICAZIONI ORALI: Farmacologia della muscolatura liscia<br />
Moderatori: G. Sgaragli (Siena) – G. Sava (Trieste)<br />
Ore Abs. book<br />
page<br />
8.30 FLAVONOIDS: A NEW CLASS OF VASCULAR SMOOTH MUSCLE L-TYPE<br />
Ca 2 + CHANNEL MODULATORS<br />
Fusi F., Saponara S., Pess<strong>in</strong>a F., Gorelli B., Fros<strong>in</strong>i M., Sgaragli G.<br />
Dipartimento <strong>di</strong> Scienze Anatomiche e Biome<strong>di</strong>che, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena,<br />
via A. Moro 2, 53100 SIENA.<br />
8.45 VASCULAR HYPOREACTIVITY TO CONTRACTING AND RELAXING<br />
AGENTS IN MECHANICAL INJURED RAT CAROTID ARTERY<br />
P<strong>in</strong>to A., Lippolis L., Popolo A., Maffia P, * D'Emmanuele <strong>di</strong> Villa Bianca R.,<br />
*Sorrent<strong>in</strong>o R., Autore G., *Sorrent<strong>in</strong>o L.<br />
Department of Pharmaceutical Sciences, University of Salerno, Italy. *Department of<br />
Experimental Pharmacology, University “Federico II” of Naples, Italy.<br />
9.00 ROLE OF CALCIUM FLUX AND MYOSIN HEAVY CHAIN IN VASCULAR<br />
HYPOREACTIVITY IN MECHANICAL INJURED RAT CAROTID ARTERY<br />
Popolo A., Lippolis L., *Sorrent<strong>in</strong>o R., Nasti C., *D’Emmanuele <strong>di</strong> Villa Bianca R.,<br />
Marzocco S., Autore G., P<strong>in</strong>to A.<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Salerno.<br />
*Dipartimento <strong>di</strong> Farmacologia Sperimentale, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Napoli<br />
“Federico II”.<br />
9.15 ADENOSINE INHIBITION OF PHENYLEPHRINE-INDUCED CONTRACTIONS,<br />
IN AORTA AND CAROTID ARTERIES OF RATS, REQUIRED<br />
INTRACELLULAR MECHANISM<br />
Nasti C., P<strong>in</strong>to A.<br />
Department of Pharmacological Sciences, <strong>Università</strong> <strong>di</strong> Salerno<br />
9.30 THE ANTITUMOR RUTHENIUM COMPOUND NAMI-A AFFECTS a1<br />
COUPLED MECHANISMS IN VASCULAR SMOOTH MUSCLE IN VIVO AND<br />
IN VITRO<br />
Vadori M. 1 , Florio C. 1 1 ,2<br />
, Sava G.<br />
1 2<br />
Department of Biome<strong>di</strong>cal Sciences University of Trieste, Fondazione Callerio<br />
ONLUS, Trieste<br />
12<br />
61<br />
109<br />
113<br />
98<br />
141
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page<br />
9.45 EVIDENCE FOR b3 RECEPTOR INVOLVEMENT IN THE ERECTILE<br />
MECHANISM VIA A CYCLIC GMP NO-INDEPENDENT PATWAY IN HUMAN<br />
CORPUS CAVERNOSUM STRIPS<br />
Sorrent<strong>in</strong>o R. 1 , d’Emmanuele <strong>di</strong> Villa Bianca R. 1 , Popolo A. 2 , Palmieri S. 3 ,<br />
Mirone V. 3 , ImbimboC. 3 , Ignarro J.L. 4 , Cir<strong>in</strong>o G. 1<br />
1 Department of Experimental Pharmacology, University of Naples; 2 Department of<br />
Pharmaceutical Sciences, University of Salerno; 3 Department of Urology, University<br />
of Naples; 4 Department of Molecular Pharmacology, University of California, Los<br />
Angeles<br />
10.00 INTERACTIONS BETWEEN TWO Ca 2+ CHANNEL ACTIVATORS,<br />
QUERCETIN AND BAY K 8644, IN VASCULAR SMOOTH MUSCLE<br />
Saponara S, Fros<strong>in</strong>i M, Sgaragli GP, Fusi F<br />
Dipartimento <strong>di</strong> Scienze Anatomiche e Biome<strong>di</strong>che, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena,<br />
via Aldo Moro, 2; 53100 Siena<br />
10.15 MELATONIN REVERTS THE LIPOPOLYSACCAHARIDE (LPS) INDUCED<br />
HIPOREACTIVITY IN A VIVO AND IN VITRO MODEL IN RAT<br />
d’Emmanuele <strong>di</strong> Villa Bianca R. 1 , Cuzzocrea S. 2 , Serra<strong>in</strong>o I. 2 , Marzocco S. 3 ,<br />
Autore G. 3 , P<strong>in</strong>to A. 3 , Sorrent<strong>in</strong>o R. 1<br />
1 2<br />
Department of Experimental Pharmacology, University of Naples, Institute of<br />
Pharmacology, University of Mess<strong>in</strong>a, 3 Department of Pharmaceutical Sciences,<br />
University of Salerno<br />
13<br />
131<br />
125<br />
43
VENERDI’ 27 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 11.00 – 13.00<br />
MINISIMPOSIO: Farmaci antitumorali selettivi e nuovi farmaci citotossici: promesse che saranno<br />
mantenute?<br />
Moderatori: T. Mazzei (Firenze) – R. Danesi (Pisa)<br />
In collaborazione con la Società Italiana <strong>di</strong> Chemioterapia<br />
11.00 I nuovi composti <strong>di</strong> org<strong>in</strong>e mar<strong>in</strong>a.<br />
M. D’Incalci (Milano)<br />
11.20 I nuovi composti antifolici ad attività antitumorale.<br />
E. M<strong>in</strong>i (Firenze)<br />
11.40<br />
Gli <strong>in</strong>ibitori <strong>di</strong> tiros<strong>in</strong>a ch<strong>in</strong>asi: il modello dell’Epidermal Growth Factor receptor.<br />
G. Tortora (Napoli)<br />
12.00 Le strategie antisenso.<br />
A. Nicol<strong>in</strong> (Milano)<br />
12.20 I derivati <strong>di</strong> aloe-emod<strong>in</strong>: una nuova classe <strong>di</strong> composti ad azione antitumorale.<br />
G. Palù (Padova)<br />
14
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 11.00 – 13.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Neuropsicofarmacologia<br />
Moderatori: S. Amoroso (Ancona) – G. Schett<strong>in</strong>i (Genova)<br />
Ore Abs. book<br />
page<br />
11.00 SEROTONIN SELECTIVE REUPTAKE INHIBITORS AND NEUROGENESIS<br />
Zusso M., Imbesi M., Guidol<strong>in</strong> D.*, Debetto P., Giusti P.<br />
Departments of Pharmacology and Anesthesiology and *Human Anatomy and<br />
Physiology, University of Padova.<br />
11.15 SELECTIVE EFFECTS OF ANTIDEPRESSANTS ON CREB<br />
PHOSPHORYLATION AND RELATED KINASE CASCADES<br />
Tiraboschi E 1 , Moraschi S 2 , Tar<strong>di</strong>to D 1 , Kasahara J 3 , Gennarelli M 2 , Racagni G<br />
1,3 , Popoli M 1 .<br />
1 Center of Neuropharmacology - Dept. Pharmacol. Sciences, University of Milano; 2<br />
Genetic Unit, IRCCS Centro San Giovanni <strong>di</strong> Dio-FBF, Brescia (Italy); 3 Department<br />
of Pharmacology, Tohoku University, Sendai (Japan)<br />
11.30 BLOCKADE OF NOCICEPTIN/ORPHANIN FQ – NOP RECEPTOR SIGNALING<br />
PRODUCES ANTIDEPRESSANT-LIKE EFFECTS<br />
1 Calò G, 1 ,2 Gavioli EC, 1 Marzola G, 3 Guerr<strong>in</strong>i R, 3 Salvadori S, 1 Zucch<strong>in</strong>i S, 2<br />
De Lima TCM, 2 Rae GA, 1 Regoli D.<br />
1 Dept. of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology, University<br />
of Ferrara, Italy; 2 Dept. of Pharmacology, CCB, Universidade Federal de Santa<br />
Catar<strong>in</strong>a, Florianopolis, Brazil; 3 Department of Pharmaceutical Sciences, University<br />
of Ferrara, Italy.<br />
11.45 EVIDENCE THAT ENDOGENOUS BENZODIAZEPINE-LIKE COMPOUNDS<br />
INCREASE DURING SPONTANEOUS DELIVERY<br />
Avallone R., *Modugno G. *Facch<strong>in</strong>etti F., M. Baral<strong>di</strong><br />
Dept. of Pharmaceuticals Sciences, Via Campi 183 and *Mother-Infant Dept., Via del<br />
Pozzo 71, 41100 Modena, Modena and Reggio Emilia University<br />
12.00 BLOCKADE OF MGLU5 GLUTAMATE RECEPTORS PREVENTS AN EARLY<br />
OVER-EXPRESSION OF PRO-APOPTOTIC GENES AND MORPHOLOGICAL<br />
CHANGES IN DORSAL HORN LAMINA II IN A MODEL OF NEUROPATHIC<br />
PAIN IN RAT<br />
DeNovellis V., S<strong>in</strong>iscalco D., Marabese I., Fuccio C., Vacca C., Rossi F., Maione S.<br />
Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale Sezione <strong>di</strong> Farmacologia “L. Donatelli”<br />
Facoltà <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Chirurgia Seconda <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> Napoli<br />
12.15 THE ROLE OF PERIAQUEDUCTAL GRAY AREA (PAG) GLUTAMATE<br />
RECEPTORS IN HYPERALGESIA INDUCED BY ILOPROST<br />
Oliva P., de Novellis V., Scotto <strong>di</strong> Mase G., Mariani L., Maione S., Rossi F., Berr<strong>in</strong>o<br />
L.<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology "L. Donatelli",<br />
Faculty of Me<strong>di</strong>c<strong>in</strong>e and Surgery, Second University of Naples<br />
15<br />
148<br />
137<br />
21<br />
4<br />
44<br />
99
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page<br />
12.30 RETROSPECTIVE EVALUATION OF BUPRENORPHINE SUBSTITUTION<br />
THERAPY IN OPIATE ADDICTED OUTPATIENTS<br />
M. Ghia 1 , R. Canepa 1 , F. Bruno 1 , M. Mollica 1 , M.G. Roccatagliata 1 , R. Urciuoli 1<br />
, P.G. Semboloni 1 , A. Martelli 2<br />
1 Ad<strong>di</strong>ction dept., U.O. SERT Ponente, Ambito Territoriale 2, ASL 3 Genovese, 2<br />
Pharmacology and Toxicology Unit, Di.M.I., University of Genoa<br />
12.45 LONG-TERM EFFECTS OF NICOTINE ON FEEDING BEHAVIOUR AND<br />
BODY WEIGHT GAIN IN FEMALE MICE<br />
Catania M.A., Mannucci C., Caputi A.P., Calapai G.<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology, School of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Mess<strong>in</strong>a, Italy<br />
16<br />
68<br />
29
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 1A<br />
Ore 11.00 – 13.00<br />
MINISIMPOSIO: Recettori nativi per il glutammato: implicazioni <strong>in</strong> fisiologia e patologia.<br />
Moderatori: F. Nicoletti (Roma) – M. Raiteri (Genova)<br />
11.00 Organizzazione strutturale dei recettori NMDA per il glutammato nelle densità<br />
posts<strong>in</strong>aptiche.<br />
M. Di Luca (Milano)<br />
11.20 I recettori per il glutammato, bersagli neuronali delle toss<strong>in</strong>e virali <strong>di</strong> HIV-1.<br />
A. Pittaluga (Genova)<br />
11.40 Ruolo dei recettori mGlu1 nel danno neuronale post-ischemico.<br />
E. Meli (Firenze)<br />
12.00 Recettori metabotropici per il glutammato e cellule stam<strong>in</strong>ali neurali.<br />
D. Melchiorri (Roma)<br />
12.20 Recettori metabotropici del glutammato come “target” della terapia antipark<strong>in</strong>soniana.<br />
G. Battaglia (Pozzilli)<br />
12.40 Recettori metabotropici del glutammato e dolore<br />
S. Maione (Napoli)<br />
17
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 1B<br />
Ore 11.00 – 13.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Farmacologia cl<strong>in</strong>ica<br />
Moderatori: C. Riccar<strong>di</strong> (Perugia) – L. Steardo (Palermo)<br />
Ore Abs. book<br />
page<br />
11.00 EFFECT OF LIVER FUNCTIONAL STATUS ON THE PHARMACOKINETIC<br />
INTERACTION BETWEEN THE CYP1A2 INHIBITOR FLUVOXAMINE AND<br />
LIDOCAINE<br />
Pietro Palat<strong>in</strong>i 1 , Pierpaolo Piccoli 1 , Roberto Padr<strong>in</strong>i 1 , Rocco Orlando 2<br />
1 Department of Pharmacology and Anaesthesiology, and 2 Department of Me<strong>di</strong>cal<br />
and Surgical Sciences, University of Padova, Padova, Italy<br />
11.15 CLINICAL PHARMACOLOGY OF PLATELET AND VASCULAR<br />
CYCLOOXYGENASE INHIBITION BY NAPROXEN AND LOW-DOSE<br />
ASPIRIN<br />
Capone M. L, Tacconelli S, Patrono C *, Patrignani P<br />
Depts Me<strong>di</strong>c<strong>in</strong>e & Ag<strong>in</strong>g, “G. ’Annunzio” University of Chieti, and *Pharmacology,<br />
“La Sapienza” University of Rome, Italy<br />
11.30 CYCLOSPORINE BLOOD CONCENTRATIONS PREDICTION IN BONE<br />
MARROW TRANSPLANTED PATIENTS<br />
Pavan F., Baraldo M., Franceschi L., Pea F., Furlanut M.<br />
Chair of Pharmacology, DPMSC, Me<strong>di</strong>cal School, University of Ud<strong>in</strong>e, Italy<br />
11.45 A PHARMACOKINETIC-PHARMACODYNAMIC METHOD FOR PREDICTING<br />
WARFARIN MAINTENANCE DOSE. PRELIMINARY RESULTS.<br />
Barban M 1 , Pengo V 1 , Scordo MG 2 , Di Menza G 3 , Sp<strong>in</strong>a E 2 , Ferrari M 1 , Padr<strong>in</strong>i<br />
R 3 .<br />
1 Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e University of Padova. 2<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology, University of<br />
Mess<strong>in</strong>a. 3 Department of Pharmacology and Anesthesiology, University of Padova,<br />
Italy.<br />
12.00 TUBEROSE SCLEROSIS COMPLEX 2: MOLECULAR AND CELLULAR<br />
ADAPTATIONAL STRATEGIES TRIGGERED BY THE LACK OF TUBERIN<br />
Alfredo Gorio, Laura Madaschi, Elena Lesma, Silvano Bosari, Diego Brancaccio,<br />
Paola Canev<strong>in</strong>i, Anna Maria Di Giulio<br />
Laboratory of Pharmacology, Dept. Me<strong>di</strong>c<strong>in</strong>e, Surgery and Dentistry, Faculty of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Milan, Via A. Di Rud<strong>in</strong>i’ 8, 20142 Milan, Italy<br />
12.15 APPLICATION OF PARZEN-BASED PROBABILISTIC NEURAL NETWORKS<br />
TO PREDICT INDIVIDUAL PLASMA CONCENTRATION FROM<br />
POPULATION DATA<br />
*Casale F., °Costa M., *Canaparo R., *Muntoni E., *Della Pepa C., *Berno E.,<br />
*Zara G.P., °Pasero E., *Ean<strong>di</strong> M.<br />
* Department of Anatomy, Pharmacology and F.M. – University of Tor<strong>in</strong>o, Italy. °<br />
Department of Electronics - Politechnic of Tor<strong>in</strong>o, Italy<br />
18<br />
102<br />
23<br />
105<br />
7<br />
71<br />
26
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page<br />
12.30 IMPACT OF GENDER ON ADRs: DATA OF SPONTANEOUS REPORTING IN<br />
EMILIA ROMAGNA, LOMBARDIA, VENETO REGIONS AND PROVINCIA<br />
AUTONOMA OF TRENTO<br />
Piazzetta V. 1 , Meneghelli I. 1 , Mozzo F. 1 , Conforti A. 1 , Cocci A. 2 , Montanaro N. 3<br />
, Velo G.P. 1<br />
1 Cl<strong>in</strong>ical Pharmacology Unit, University of Verona, Verona; 2 Pharmaceutical Unit,<br />
ASL, Cremona, 3 Interuniversity Research Centre for Pharmacoepidemiology,<br />
Department of Pharmacology, University of Bologna, Bologna<br />
12.45 DIFFERENT RISK FOR DRUGS-INDUCED ANAPHYLAXIS: DATA OF<br />
SPONTANEOUS REPORTING IN EMILIA ROMAGNA, LOMBARDIA,<br />
VENETO REGIONS AND PROVINCIA AUTONOMA OF TRENTO<br />
Meneghelli I. 1 , Piazzetta V. 1 , Mozzo F. 1 , Leone R. 1 , Venegoni M. 2 , Motola D. 3 ,<br />
Moretti U. 1<br />
1 2<br />
Cl<strong>in</strong>ical Pharmacology Unit, University of Verona, Verona; Department of<br />
Me<strong>di</strong>c<strong>in</strong>e, Fatebenefratelli Hospital, Milan; 3 Interuniversity Research Centre for<br />
Pharmacoepidemiology, Department of Pharmacology, University of Bologna,<br />
Bologna<br />
19<br />
108<br />
91
VENERDI’ 27 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 16.00 – 18.00<br />
MINISIMPOSIO: Farmacologia del dolore cronico: prospettive future.<br />
Moderatori: A. Reggiani (Milano) - L. Negri (Roma)<br />
16.00 Novel approaches to the treatment of chronic pa<strong>in</strong>.<br />
J.C. Hunter (Kenilworth, NJ)<br />
16.30 Bv8-Prok<strong>in</strong>etic<strong>in</strong>e system: a novel target to the pharmacological treatment of chronic pa<strong>in</strong>.<br />
L. Negri (Roma)<br />
17.00 Rapid modulation of P2X3 receptor function may account for changes <strong>in</strong> pa<strong>in</strong> signall<strong>in</strong>g by<br />
nociceptive neurons.<br />
R. G<strong>in</strong>iatull<strong>in</strong> (Trieste)<br />
17.30 Possibile role of melanocort<strong>in</strong> system <strong>in</strong> chronic pa<strong>in</strong> modulation.<br />
R. Bertorelli (Milano)<br />
20
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 16.00 – 18.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Farmacologia car<strong>di</strong>ovascolare I<br />
Moderatori: L. Berr<strong>in</strong>o (Napoli) – S. Guar<strong>in</strong>i (Modena)<br />
Ore Abs. book<br />
page<br />
16.00 EDHF IS INVOLVED IN INSULIN-INDUCED VASORELAXATION IN<br />
MESENTERIC VASCULAR BED FROM RATS WITH ESTABLISHED<br />
HYPERTENSION<br />
Potenza M.A., Marasciulo FL., Nacci C., Porro C., Montagnani M., Chieppa Mitolo<br />
D.<br />
Department of Pharmacology and Human Physiology, Me<strong>di</strong>cal School, University of<br />
Bari, Italy.<br />
16.15 VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) MAY INDUCE<br />
ERYTHROPOIETIN EXPRESSION IN THE BRAIN<br />
Marciano M.C. a , Bellomo M. b , Catania M.A. a , Mannucci C. a , Mar<strong>in</strong>i H. a , Deodato<br />
B. a , Squadrito F. a , Caputi A.P. a , Calapai G. a<br />
a Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology, School of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Mess<strong>in</strong>a, Italy. b Department of Biochemical, Physiological<br />
and Nutritional Sciences, School of Me<strong>di</strong>c<strong>in</strong>e, University of Mess<strong>in</strong>a<br />
16.30 SPHINGOSINE-1-PHOSPHATE INDUCE VASORELAXATION IN VITRO<br />
THROUGH ENOS ACTIVATION<br />
Roviezzo F., Bucci M 1 ,.Brancaleone V 1 , Martuscelli P 1 ., Parente L., Cir<strong>in</strong>o G 1 .<br />
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Salerno,<br />
Italy 1 Department of Experimental Pharmacology, Faculty of Pharmacy, University<br />
of Naples “Federico II” Italy<br />
16.45 DIABETES IMPAIRS ESTROGEN CONTROL OF INDUCIBLE NO SYNTHASE<br />
IN VASCULAR SMOOTH MUSCLE CELLS BY AFFECTING THE<br />
EXPRESSION PATTERN OF ESTROGEN RECEPTORS<br />
Cignarella A, M<strong>in</strong>ici C, Brusadelli A, Bolego C, Maggi A, Puglisi L.<br />
Department of Pharmacological Sciences, University of Milan, via Balzaretti 9,<br />
20133 Milan, Italy<br />
17.00 PROBUCOL INHIBITION OF ABCA1-MEDIATED CELLULAR LIPID EFFLUX<br />
Bern<strong>in</strong>i F. 1 , Favari E. 1 , Zanotti I. 1 , Zimetti F. 1 , Ronda N. 2 , Rothblat G.H. 3<br />
1 Dept. of Pharmacological and Biological Sciences and Applied Chemistry,<br />
University of Parma; 2 Dept. of Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, Nephrology and Health Sciences,<br />
University of Parma; 3 G.I. and Nutrition, Dept. of Pe<strong>di</strong>atrics The Children’s Hospital<br />
of Philadelphia, USA<br />
17.15 RALOXIFENE REDUCES MATRIX METALLOPROTEINASES SECRETION BY<br />
CULTURED MACROPHAGES AND SMOOTH MUSCLE CELLS<br />
Monetti M, Canavesi M., Baetta R, Paoletti R, Bern<strong>in</strong>i F. *, Cors<strong>in</strong>i A, Bellosta S.<br />
Department of Pharmacological Sciences and *Department of Pharmacological and<br />
Biological Sciences and Applied Chemistry, University of Parma, Italy<br />
21<br />
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83<br />
121<br />
33<br />
11<br />
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page<br />
17.30 INHIBITION OF METALLOPROTEINASE-9 ACTIVITY AND GENE<br />
EXPRESSION BY POLYPHENOLIC COMPOUNDS ISOLATED FROM THE<br />
BARK OF TRISTANIOPSIS CALOBUXUS (MYRTACEAE)<br />
Canavesi M., Dell’Agli M., Monetti M, Mitro N, Crestani M, Verotta L. °, Fuzzati N<br />
# , Bern<strong>in</strong>i F. *, Bosisio E, Bellosta S.<br />
Department of Pharmacological Sciences and ° Department of Organic and Industrial<br />
Chemistry, University of Milan, Milan; # INDENA S.p.A, Milan; *Department of<br />
Pharmacological and Biological Sciences and Applied Chemistry, University of<br />
Parma, Italy<br />
17.45 AXL, A TIROSYNE KINASE RECEPTOR AND HIS LIGAND GAS6 , ARE<br />
INVOLVED IN ANGIOGENESIS<br />
M.Gallicchio, S. Mitola*, D. Valdembri*, F. Bussol<strong>in</strong>o*, R. Fantozzi.<br />
Dipartimento <strong>di</strong> Anatomia, Farmacologia e Me<strong>di</strong>c<strong>in</strong>a Legale, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />
<strong>di</strong> Tor<strong>in</strong>o, Tor<strong>in</strong>o. *Dipartimento <strong>di</strong> Genetica, Biologia e Biochimica, <strong>Università</strong><br />
<strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Tor<strong>in</strong>o, Tor<strong>in</strong>o<br />
22<br />
22<br />
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VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 1A<br />
Ore 16.00 – 18.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Neurofarmacologia: danno ischemico<br />
Moderatori: G. Biggio (Cagliari) - R. Corradetti (Firenze)<br />
Ore Abs. book<br />
page<br />
16.00 REDUCTION OF BRAIN DAMAGE BY SIMVASTATIN: DIFFERENT<br />
NEUROPROTECTIVE MECHANISMS IN ADULT AND NEONATAL MODELS<br />
OF CEREBRAL ISCHEMIA<br />
Cim<strong>in</strong>o M., Mazzoni E., Carloni S., Sironi L. *, Gerosa P. *, Lodetti B. *, Tremoli E.<br />
*, Baldu<strong>in</strong>i W.,<br />
Istituto <strong>di</strong> Farmacologia e Farmacognosia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urb<strong>in</strong>o, Via S.<br />
Chiara 27, Urb<strong>in</strong>o. * Dipartimento <strong>di</strong> Scienze Farmacologiche, <strong>Università</strong> <strong>di</strong> Milano,<br />
Via Balzaretti 9, Milano<br />
16.15 CASPASE 1 INHIBITORS REDUCE CYTOCHROME C TRANSLOCATION BUT<br />
NOT ENHANCEMENT OF IL-1BETA CAUSED BY THE HIV-1 GP120 IN THE<br />
NEOCORTEX OF RAT<br />
Bagetta G. a , Navarra M. b , Russo R. b , Corasaniti M.T. b<br />
a Department of Pharmacobiology, University of Calabria, Arcavacata <strong>di</strong> Rende (CS)<br />
Italy; b Department of Pharmacobiological Sciences, Faculty of Pharmacy, University<br />
Magna Graecia of Catanzaro, Italy<br />
16.30 ADENOSINE CONTROL OF VESICULAR-LIKE GLUTAMATE RELEASE<br />
FROM RAT CEREBROCORTEX SLICES DURING ISCHEMIA<br />
Marcoli M., Bonfanti A., 1 Ong<strong>in</strong>i E., 1 Monopoli A., Roccatagliata P., Cervetto C.,<br />
Maura G., Raiteri M.<br />
Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale, Sez. <strong>di</strong> Farmacologia e Tossicologia,<br />
Genova; 1 Scher<strong>in</strong>g-Plough Research Institute, San Raffaele Science Park, Milano;<br />
present address: Nicox Research Institute, Bresso, Milano<br />
16.45 SIMVASTATIN AND NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY:<br />
INVOLVEMENT OF PRO-INFLAMMATORY CYTOKINES AND CASPASE-3<br />
ACTIVATION<br />
E. Mazzoni, S. Carloni, M.G. De Simoni 1 , M. Cim<strong>in</strong>o, W. Baldu<strong>in</strong>i<br />
Istituto <strong>di</strong> Farmacologia e Farmacognosia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urb<strong>in</strong>o, Via S.<br />
Chiara 27, Urb<strong>in</strong>o; 1 Istituto <strong>di</strong> Ricerche “Mario Negri”, Via Eritrea 62, Milano<br />
17.00 CAPSAZEPINE PROTECTS AGAINST CEREBRAL ISCHEMIA-INDUCED EEG<br />
FLATTENING, HYPERMOTILITY, COGNITIVE DEFICIT AND NEURONAL<br />
DEATH IN GERBILS<br />
Pegor<strong>in</strong>i S., Braida D., Consalez G. *., Croci L.* Sala M.<br />
Dipartimento <strong>di</strong> Farmacologia, Chemioterapia e Tossicologia me<strong>di</strong>ca, <strong>Università</strong><br />
<strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano, Via Vanvitelli 32, 20129 Milano. * San Raffaele Scientific<br />
Institute, Milan, Italy<br />
23<br />
34<br />
6<br />
84<br />
90<br />
106
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page<br />
17.15 DEVELOPMENT OF A NEW CLASS OF IONOTROPIC GLUTAMATE<br />
RECEPTORS ANTAGONISTS (BENZOTHIADIAZIDES DERIVATIVES) AS<br />
POTENTIAL NEUROPROTECTIVE AGENTS<br />
Giulia Puia , Gabriele Losi, Daniela Braghiroli*, Mario Baral<strong>di</strong><br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Modena e Reggio<br />
Emilia, Via Campi 183, 41100 Modena, Italy and *Dipartimento <strong>di</strong> Scienze del<br />
Farmaco, Universita` <strong>degli</strong> <strong>Stu<strong>di</strong></strong> “G. D’Annunzio” Chieti, Via dei Vest<strong>in</strong>i, 66013<br />
Chieti, Italy<br />
17.30 ROSUVASTATIN INHIBITS INFLAMMATORY PROCESSES AND PREVENTS<br />
BRAIN ABNORMALITIES IN STROKE-PRONE RATS<br />
Luigi Sironi, Elisabetta Gianazza, Uliano Guerr<strong>in</strong>i, Barbara Lodetti, Paolo Gelosa,<br />
Benedetta Cremonesi, Rodolfo Paoletti, Elena Tremoli<br />
Department of Pharmacological Sciences, University of Milan, and Monz<strong>in</strong>o<br />
Car<strong>di</strong>ologic Center, Milan, Italy<br />
17.45 PROTECTIVE ROLE OF SYNTHETIC HDL FROM ISCHEMIA-REPERFUSION<br />
INJURY: EX VIVO AND IN VIVO MODELS<br />
M. Marchesi 1 , EA. Booth 2 , KR. Hill 3 , CR. Sirtori 1 , CL. Bisgaier 3 , BR. Lucchesi 2<br />
1 Department of Pharmacological Sciences, University of Milan, via Balzaretti 9,<br />
20133 Milan, Italy; 2 University of Michigan Me<strong>di</strong>cal School, Department of<br />
Pharmacology, Ann Arbor, MI, USA, 48109-0632; 3 Esperion Therapeutics, Inc.,<br />
Ann Arbor, MI, USA, 48108<br />
24<br />
115<br />
130<br />
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VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 1B<br />
Ore 16.00 – 18.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Chemioterapia I<br />
Moderatori: F. Bartoli (Trieste) – G. Toffoli (Aviano)<br />
Ore Abs. book<br />
page<br />
16.00 TAMOXIFEN AND ITS METABOLITES IN BREAST CANCER WOMEN.<br />
Franceschi L.*, Cagol P.**, Pasqual E.**, Cartei G., Giorda G., Furlanut M.*<br />
*Institute of Cl<strong>in</strong>ical Pharmacology and Toxicology, DPMSC, and **Derpartement<br />
of General Surgery, University of Ud<strong>in</strong>e Italy<br />
16.15 MDR1, MRP2 AND UGT1A1 POLYMORPHISMS IN OVARIAN CANCER<br />
Cecch<strong>in</strong> E., Corona G., Biscont<strong>in</strong> G., Sartor F., Muzz<strong>in</strong> S., Biason P., Steffan A.,<br />
Martella L., Toffoli G.<br />
Experimental and Cl<strong>in</strong>ical Pharmacology Unity-National Cancer Institute- C.R.O.-<br />
Aviano-Italy<br />
16.30 IMPACT OF NONSTEROIDAL ANTI-INFLAMMATORY AGENTS (NSAIDS)<br />
ON MALIGNANT MESOTHELIOMA CHEMOPREVENTION: PRECLINICAL<br />
EVALUATION OF CELECOXIB AS THERAPEUTIC TOOL<br />
Catalano A. 3 , Graciotti L. 1 , Gianni W. 2 , Procopio A. 1 , Amoroso S. 3<br />
1 Department of Molecular Pathology and Innovative Therapies, University<br />
Polytechnic of Marche, Ancona, Italy; 2 UO Oncologia INRCA, Rome, Italy; 3<br />
Department of Pharmacology, University Polytechnic of Marche, Ancona, Italy<br />
16.45 MODULATION OF DIHYDROPYRIMIDINE DEHYDROGENASE ACTIVITY<br />
BY 5-FLUOROURACIL-BASED ADJUVANT CHEMOTHERAPY IN PATIENTS<br />
AFFECTED BY COLORECTAL CARCINOMA<br />
Di Paolo A, Vannozzi F, Danesi R, Lastella M, *Falcone A, § Ibrahim T, § Amadori D,<br />
Del Tacca M<br />
Department of Oncology, Transplants and Advanced Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e,<br />
University of Pisa; *Division of Me<strong>di</strong>cal Oncology, Civil Hospital, Livorno;<br />
§ Department of Me<strong>di</strong>cal Oncology, Pierantoni Hospital, Forlì, Italy<br />
17.00 LOW-DOSE ASPIRIN SUPPRESSES ENHANCED THROMBOXANE<br />
BIOSYNTHESIS IN PATIENTS WITH COLORECTAL CANCER<br />
Sciulli M.G., Filabozzi P., Tacconelli S., Seta F., Patrignani P.<br />
Department of Me<strong>di</strong>c<strong>in</strong>e & Ag<strong>in</strong>g, “G. d’Annunzio” University, Chieti, Italy<br />
17.15 INTRAVESICAL GEMCITABINE TREATMENT FOR SUPERFICIAL URINARY<br />
BLADDER CARCINOMA: A PHASE II STUDY<br />
F. Mattioli, M. Gosmar, R. Croci, V. Manfre<strong>di</strong><br />
Pharmacology and Toxicology Unit, Di.M.I., University of Genoa<br />
25<br />
59<br />
30<br />
28<br />
50<br />
127<br />
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17.30 EFFECTS OF STATIC AND EXTREMELY LOW FREQUENCY (ELF)<br />
MAGNETIC FIELDS (MF) IN ASSOCIATION WITH ANTICANCER DRUGS<br />
Barone D., Peroglio F., Toso E., Ossola P.*, Berardelli M., Tofani S.*<br />
LCG-RBM SpA, Via Ribes, 1, 10010 – Colleretto Giacosa (TO) Italy * Department<br />
of Me<strong>di</strong>cal Physics, Ivrea Hospital, ASL9, 10015 – Ivrea (TO) Italy<br />
17.45 HIGH THYMIDYLATE SYNTHASE LEVELS IN COLORECTAL CANCER:<br />
PREDICTIVE, PROGNOSTIC OR NOTHING ?<br />
Sanguedolce R*, Calascibetta A*, Rausa L**, Buettner R***, Feo S**, Aragona<br />
F****, Barresi E****, Campione M. ****, Dardanoni G, Cabibi D. ****<br />
Dipartimenti <strong>di</strong> Scienze Farmacologiche* e <strong>di</strong> Oncologia Sperimentale ed<br />
Applicazioni Cl<strong>in</strong>iche**, Istituti <strong>di</strong> Patologia dell’<strong>Università</strong> <strong>di</strong> Bonn*** e <strong>di</strong><br />
Anatomia Patologica**** della Facoltà <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Chirurgia dell’<strong>Università</strong> agli<br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> Palermo. Osservatorio Epidemiologico Regionale <strong>di</strong> Palermo<br />
26<br />
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VENERDI’ 27 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 18.30 – 19.30<br />
SIMPOSIO SATELLITE: Escitalopram: l’<strong>in</strong>novazione attraverso l’evoluzione.<br />
Moderatori: F. Drago (Catania) - G. Racagni (Milano)<br />
18.30 Un mondo <strong>di</strong> chiralità – farmacod<strong>in</strong>amica e farmacoc<strong>in</strong>etica <strong>di</strong> Escitalopram.<br />
N. Brunello (Modena)<br />
18.50 Escitalopram: nuove prospettive per il trattamento delle s<strong>in</strong>dromi depressive.<br />
E. Aguglia (Trieste)<br />
19.10 Escitalopram: nuove prospettive per il trattamento dei <strong>di</strong>sturbi d’ansia.<br />
S. Pallanti (Firenze)<br />
27
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 2C<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia dei recettori, dei meccanismi <strong>di</strong> trasduzione del segnale e<br />
dei canali ionici.<br />
POSTER 1-14<br />
Moderatore: M. Simonato (Ferrara).<br />
Poster<br />
n°<br />
1. BV-8 INDUCED HYPERALGESIA: MOLECULAR SIGNALING PATHWAYS<br />
Lattanzi R., Negri L., Melchiorri P.<br />
Department of Human Physiology and Pharmacology, University of Rome "La<br />
Sapienza"<br />
2. Gi PROTEINS: RECOMBINANT DNA APPROACH<br />
Di Cesare Mannelli L. 1 , Pac<strong>in</strong>i A. 2 , Bartol<strong>in</strong>i A. 1 .<br />
1 Department of Pharmacology, University of Florence, V.le Pieracc<strong>in</strong>i 6 50134<br />
Florence; 2 Department of Anatomy, Histology and Forensic Me<strong>di</strong>c<strong>in</strong>e, V.le Morgagni<br />
85, 50134 Florence<br />
3. MODIFICATIONS OF DARPP-32 PHOSPHORYLATION STATE INDUCED BY<br />
ACUTE MORPHINE ADMINISTRATION OR UNAVOIDABLE STRESS<br />
EXPOSURE IN MORPHINE SENSITIZED RATS<br />
De Montis MG 1 ,2 , Rauggi R, 1 Scheggi S, 1 Gambarana C, 1 Tagliamonte A. 1<br />
1 2<br />
Department of Neuroscience, University of Siena, Italy; Department of Drug<br />
Sciences, University of Sassari, Italy<br />
4. STAUROSPORIN-INDUCED APOPTOSIS INFLUENCES APP METABOLISM<br />
AND ITS SIGNALLING THROUGH SHCA<br />
Venezia V., Russo C., Salis S., Dolc<strong>in</strong>i V., Repetto E., Genova F., Nizzari M., Schett<strong>in</strong>i<br />
G.<br />
Pharmacology and Neuroscience National Cancer Institute (IST) c/o Advanced<br />
Biotechnology Center and Section of Pharmacology Department of Oncology, Biology<br />
and Genetics University of Genova, Italy<br />
5. THE PHOSPHOLIPASE C-IP3 PATHWAY IS INVOLVED IN MUSCARINIC<br />
ANTINOCICEPTION<br />
Ghelard<strong>in</strong>i C., Galeotti N., 1 Nicolai R., 1 Calvani M., 1 Mosconi L., Bartol<strong>in</strong>i A.<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, Viale G. Pieracc<strong>in</strong>i 6, 50139<br />
Florence; 1 Sigma-Tau S.p.A., Via Pont<strong>in</strong>a km 30,400, 00040 Pomezia, Roma, Italy<br />
6. a2 AGONISTS INDUCE AMNESIA THROUGH ACTIVATION OF THE Gi-<br />
PROTEIN SIGNALLING PATHWAY<br />
Galeotti N., Ghelard<strong>in</strong>i C., Bartol<strong>in</strong>i A.<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, University of Florence, Viale G.<br />
Pieracc<strong>in</strong>i 6, 50139 Florence, Italy<br />
28<br />
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76<br />
47<br />
44<br />
144<br />
67<br />
62
Poster<br />
n°<br />
7. CYTOCHEMICAL AND FUNCTIONAL CHARACTERISATION OF A<br />
MEMBRANE PURINE NUCLEOSIDE PHOSPHORYLASE (ecto-PNP) IN RAT<br />
BRAIN CULTURED ASTROCYTES<br />
1 Berau<strong>di</strong> A., Giuliani P., Santavenere C., Vis<strong>in</strong>i D., Patricelli P., 1 Giuliani A.,<br />
Ciccarelli R., Di Iorio P., 1 Poli A., Caciagli F.<br />
1 Dept. of Biology and Evolutionary Zoology, University of Bologna. Italy. Dept.<br />
Biome<strong>di</strong>cal Sciences, “G. D’Annunzio” University, Chieti, Italy<br />
8. FUNCTIONAL CHARACTERIZATION OF WNT7A SIGNALLING IN PC12<br />
CELLS: INTERACTION WITH A FZD5/LRP6 RECEPTOR COMPLEX AND<br />
MODULATION BY DKK PROTEINS<br />
Motolese M 1 , Caruso A 1 , Iacovelli L 1 , Melchiorri D 1 , Nicoletti F 1 ,2 , Terstappen<br />
GC 3 , Caricasole A 3 .<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”, Piazzale Aldo Moro 5, 00185 Rome; 2 I.N.M Neuromed Pozzilli, Italy; 3<br />
Sienabiotech, Via Fiorent<strong>in</strong>a 1, 53100 Siena, Italy<br />
9. GUANOSINE PROTECTS CULTURED ASTROCYTES AGAINST<br />
STAUROSPORINE-INDUCED APOPTOSIS BY ACTIVATION OF<br />
PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY<br />
D’ Auro M., Buccella S., D’Alimonte I., Nargi E., 1 Werstiuk E., 1 Rathbone M.P.,<br />
Baller<strong>in</strong>i P., Di Iorio P., Caciagli F., Ciccarelli R.<br />
Dept. of Biome<strong>di</strong>cal Sciences, “G. D’Annunzio” University, Chieti, Italy. 1 Dept. of<br />
Me<strong>di</strong>c<strong>in</strong>e, McMaster University Health Sciences Centre, Hamilton, ON L8N 3V5<br />
Canada<br />
10. IN VIVO FUNCTIONAL CHARACTERIZATION OF PHOSPHODIESTERASE<br />
ISOFORMS DEGRADATING CYCLIC GMP IN THE CORTEX, HIPPOCAMPUS<br />
AND CEREBELLUM OF FREELY-MOVING RATS<br />
Brescia A., Pepicelli O., Raiteri M., Fedele E.<br />
Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale, Sezione <strong>di</strong> Farmacologia e Tossicologia,<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Genova, Viale Cembrano 4, 16148 Genova<br />
11. MULTI-TARGETING OF PHOSPHODIESTERASE INHIBITORS IN PC12 CELLS<br />
Righetto V, Vadori M, Florio C and Gaion RM 1<br />
Department of Biome<strong>di</strong>cal Sciences, University of Trieste and 1 Department of<br />
Pharmacology and Anaesthesiology, University of Padova<br />
12. THE HIV-1 PROTEIN TAT ELICITS SELECTIVE RELEASE OF<br />
ACETYLCHOLINE FROM HUMAN AND RAT NEOCORTICAL TERMINALS<br />
THROUGH DIFFERENT SPECIES-SPECIFIC MECHANISMS<br />
Pittaluga A. 1 ,3 , Feligioni M., 1 Raiteri L., 1 Longordo F., 1 Bruzzone S. 3 , Cavazzani<br />
P. 2 , Raiteri M.<br />
1 ,3<br />
1 Sezione <strong>di</strong> Farmacologia e Tossicologia, Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sprerimentale,<br />
<strong>Università</strong> <strong>di</strong> Genova, Italia. 2 Divisione <strong>di</strong> Neurochirurgia, Ospedale Galliera, Genova,<br />
Italia. 3 Centro <strong>di</strong> Eccellenza per la ricerca Biome<strong>di</strong>ca, <strong>Università</strong> <strong>di</strong> Genova, Genova,<br />
Italia<br />
29<br />
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10<br />
97<br />
41<br />
17<br />
118<br />
110
Poster<br />
n°<br />
13. COMPARISON OF FLECAINIDE VERSUS MEXILETINE MOLECULAR<br />
EFFECTS ON HUMAN SKELETAL MUSCLE SODIUM CHANNELS AND<br />
SODIUM CHANNEL MUTANTS RESPONSIBLE FOR MYOTONIA<br />
Desaphy J.-F., De Luca A., Didonna M.P., George A.L. Jr., Conte Camer<strong>in</strong>o D.<br />
Division of Genetic Me<strong>di</strong>c<strong>in</strong>e, Vanderbilt University, Nashville, Tennessee (ALG) and<br />
Sezione <strong>di</strong> Farmacologia, Dipartimento Farmaco-Biologico, Facoltà <strong>di</strong> Farmacia,<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Bari, (JFD, ADL, MPD, DCC)<br />
14. THE BENEFICIAL EFFECTS OF CARBONIC ANHYDRASE INHIBITORS IN THE<br />
RAT MODEL OF HYPOKALAEMIC PERIODIC PARALYSIS ARE MEDIATED<br />
BY OPENINGS OF SKELETAL MUSCLE CA 2 + -ACTIVATED K + CHANNELS<br />
Tricarico D., Barbieri M., Mele A., Talon S., Conte Camer<strong>in</strong>o D.<br />
Unit of Pharmacology, Dept of Pharmacobiology, Fac. of Pharmacy, Univ. of Bari, via<br />
orabona n° 4, 70100 Bari, Italy<br />
30<br />
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45<br />
139
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 2C<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia dei recettori e dei meccanismi <strong>di</strong> trasduzione del segnale.<br />
POSTER 15-42<br />
Moderatori: L.G. Costa (Bari) – F. Casamenti (Firenze)<br />
Poster<br />
n°<br />
15. BENZYDAMINE LOCAL ANESTEHIC ACTIVITY AND [ 3 H]-BATRACHOTOXIN<br />
BINDING SITES<br />
Mangano G., Apicella C., Vitiello M., Milanese C., Polenzani L.<br />
ACRAF SpA, S.Palomba-Pomezia, Rome, Italy<br />
16. BINDING STUDIES FOR 5-HT1A, 5-HT2A, 5-HT2C RECEPTOR OF VALERIANA<br />
ADSCENDENS EXTRACTS<br />
1 Nenc<strong>in</strong>i C., 2 Capasso A., 2 De Feo V., 1 Giorgi G., 1 Micheli L.<br />
1 Dipartimento <strong>di</strong> Farmacologia “Giorgio Segre”, <strong>Università</strong> <strong>di</strong> Siena; 2 Dipartimento <strong>di</strong><br />
Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Salerno<br />
17. COMPARATIVE STUDY WITH NALOXONE FOR TWO NEW k- AND d- OPIOID<br />
RECEPTOR ANTAGONIST<br />
Sabat<strong>in</strong>o C., W. Milano, C. Petrella, A. Papasso<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Salerno, Via Ponte Don Melillo<br />
(84084) Fisciano, Salerno<br />
18. DIABETIC MICE ANGIOPATHY IS LINKED TO PROGRESSIVE SYMPATHETIC<br />
RECEPTOR DELETION AND ENHANCED CAVEOLIN-1 EXPRESSION.<br />
Di Lorenzo A. Bucci M., Roviezzo F. 1 , Brancaleone V. 1 Parente L. 1 , Cir<strong>in</strong>o G.<br />
Depts. of Experimental Pharmacology, Faculty of Pharmacy, University of Naples<br />
–Federico II-; and 1 Pharmaceutical Science, Faculty of Pharmacy, University of<br />
Salerno, Fisciano (SA).<br />
19. EFFECT OF LOW FREQUENCY ELECTROMAGNETIC FIELDS ON A2A AND A3<br />
ADENOSINE RECEPTORS IN HUMAN NEUTROPHILS<br />
Varani K. 1 , Pancal<strong>di</strong> C. 1 , Gessi S. 1 , Cattabriga E. 1 , Merighi S. 1 , Iannotta V. 1 ,<br />
Avitabile A. 1 , Cadossi R. 2 , Borea P.A. 1<br />
1 Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Institute of Pharmacology,<br />
University of Ferrara, Italy; 2 Laboratory of Biophysics, IGEA, Carpi, Italy<br />
20. IDENTIFICATION AND CHARACTERIZATION OF NOVEL AND POTENT<br />
PEPTIDE LIGANDS FOR THE NOCICEPTIN/ORPHANIN FQ RECEPTOR<br />
Carrà G., 1 Guerr<strong>in</strong>i R., Rizzi D., Calò G., 1 Salvadori S., Regoli D.<br />
1 Dept. Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e – Section of Pharmacology, and 2 Dept of<br />
Pharmaceutical Sciences, University of Ferrara, 44100 Ferrara, Italy<br />
31<br />
Abs. book<br />
page<br />
82<br />
99<br />
122<br />
49<br />
142<br />
25
Poster<br />
n°<br />
21. ISOPROTERENOL INCREASES EXTRACELLULAR ADENOSINE FORMATION<br />
IN RAT ILEUM<br />
Giron M. C., 1 Florio C., Gaion R. M.<br />
Department of Pharmacology and Anesthesiology, University of Padova and 1<br />
Department of Biome<strong>di</strong>cal Sciences, University of Trieste<br />
22. METHANOL ACTIVATE THE VANILLOID RECEPTOR-1 (VR1) ON PRIMARY<br />
SENSORY NEURONS<br />
Campi B., Rigoni M., Tarsitano L., Harrison S., Benvenuti F., Geppetti P., Trevisani<br />
M.<br />
Inter<strong>di</strong>scipl<strong>in</strong>ary Centre of Excellence for the Study of Inflammation (ICSI), University<br />
of Ferrara, Ferrara, Italy<br />
23. mRNA DISTRIBUTION PATTERN OF Bv8/PROKINETICINS AND OF THEIR<br />
RECEPTORS IN MOUSE, RAT AND HUMAN TISSUES<br />
Giann<strong>in</strong>i E., Di Giovanni S., Melchiorri P., Negri L.<br />
Department of Human Physiology and Pharmacology, University “La Sapienza”, Rome,<br />
Italy<br />
24. MU OPIOID RECEPTOR: ROLE FOR THE THIRD EXTERNAL LOOP AS A<br />
DETERMINANT OF LIGAND BINDING AFFINITY<br />
Bianchi E. 1 , Guarna M. 2 , Ghelard<strong>in</strong>i C. 3 , Galeotti N. 3 , Bartol<strong>in</strong>i A. 3<br />
1 2<br />
Department of Neuroscience, University of Siena, Italy Department of Anatomical<br />
and Biome<strong>di</strong>cal Sciences, University of Siena, Italy 3 Department of Cl<strong>in</strong>ical and<br />
Precl<strong>in</strong>ical Pharmacology, University of Florence, Italy<br />
25. NEW MUSCARINIC ANALGESICS: IN VIVO PHARMACOLOGICAL PROFILE<br />
Bertoni S., Magnan<strong>in</strong>i F., Chiavar<strong>in</strong>i M., Ballabeni V., Impicciatore M., 1 De Amici<br />
M., 1 De Micheli C., 1 Fasoli E., Barocelli E.<br />
Dip. Scienze Farmacologiche, Biologiche e Chimiche Applicate, <strong>Università</strong> <strong>di</strong> Parma,<br />
Parco Area delle Scienze 27/A. 43100 Parma; 1 Ist. Chimica Farmaceutica e<br />
Tossicologica, <strong>Università</strong> <strong>di</strong> Milano, Viale Abruzzi, 42. 20131 Milano-Italy<br />
26. PURIFICATION AND PARTIAL AMINO ACID SEQUENCE OF A MU OPIOID<br />
RECEPTOR FROM THE NUCLEAR MEMBRANE OF RAT BRAIN CORTICAL<br />
NEURONS<br />
Guarna M. 1 , Bianchi E. 2 , Bruni G. 3 , Ghelard<strong>in</strong>i C. 4 , Galeotti N. 4 , Bartol<strong>in</strong>i A. 4<br />
1 2<br />
Department of Anatomical and Biome<strong>di</strong>cal Sciences, University of Siena, Italy<br />
Department of Neuroscience, University of Siena, Italy 3 Department of Pharmacology,<br />
University of Siena, Italy 4 Department of Cl<strong>in</strong>ical and Precl<strong>in</strong>ical Pharmacology,<br />
University of Florence, Italy<br />
27. THE ROLE OF Bv8 IN THE RAT INGESTIVE BEHAVIOUR<br />
De Felice M., Lattanzi R., Melchiorri P., Negri L.<br />
Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”, Italy<br />
32<br />
Abs. book<br />
page<br />
69<br />
22<br />
68<br />
12<br />
11<br />
72<br />
41
Poster<br />
n°<br />
28. BIOLOGICAL EFFECTS OF NOVEL 2-AMINO-3-NAPHTHOYLTHIOPHENES AS<br />
ALLOSTERIC ENHANCERS OF THE A1 ADENOSINE RECEPTOR<br />
1 Avitabile A, 2 Baral<strong>di</strong> PG, 2 Romagnoli R, 2 Tabrizi MA, 3 Leung E, 1 Iannotta V, 1<br />
Merighi S, 1 Gessi S, 1 Varani K, 1 Pancal<strong>di</strong> C, 1 Cattabriga E, 1 Borea PA.<br />
1 Dept. of Cl. & Exp. Med., Pharmacology Unit; Univ. of Ferrara, 44100, Ferrara, Italy;<br />
2 Dept of Pharmaceutical Sciences; Univ.of Ferrara, 44100, Ferrara, Italy; 3 K<strong>in</strong>g<br />
Pharmaceuticals, 27513, Cary, NC, U.S.A<br />
29. CHRONIC DESIPRAMINE TREATMENT-INDUCED CHANGES IN a 2-<br />
ADRENOCEPTORS, m- AND k-OPIOID RECEPTORS, G PROTEIN-COUPLED<br />
RECEPTOR KINASES 2/3 (GRK2/3) AND G COUPLING PROTEINS IN ENTERIC<br />
NEURONS<br />
E. Zanetti, L. Canciani, D. Giuliani, E. Moro, C. Giaroni, S. Lecch<strong>in</strong>i, G.M. Frigo<br />
Cl<strong>in</strong>ical and Applied Pharmacology Center University of Insubria and University of<br />
Pavia, Italy<br />
30. DEGRADATION AND METABOLIC EFFECTS OF EXOGENOUS ADENOSINE IN<br />
RAT ILEUM<br />
Gaion R. M., Giron M. C., 1 Florio C.<br />
Department of Pharmacology and Anesthesiology, University of Padova and 1<br />
Department of Biome<strong>di</strong>cal Sciences, University of Trieste<br />
31. EPHRINB2 INTERACTION WITH MGLU5 RECEPTORS IN THE DEVELOPING<br />
RAT STRIATUM<br />
Calò L. 1 , DiGiorgi Gerev<strong>in</strong>i V 1 , Cirica A. 1 , Nicoletti F. 1 ,2 ,Melchiorri D. 1<br />
1 Dept. of Human Physiology and Pharmacology, University of Rome “La Sapienza”,<br />
Italy. 2 I.N.M. Neuromed Pozzilli, Italy<br />
32. EXPRESSION OF FUNCTIONAL NR1/NR2B-TYPE NMDA RECEPTORS IN<br />
NEURONALLY DIFFERENTIATED SK-N-SH HUMAN CELL LINE<br />
Sarnico I, Boroni F, Bianchetti A, Moraitis C, Benarese M, Goffi F, Valerio A, Pizzi<br />
M, Spano PF.<br />
Division of Pharmacology, Department of Biome<strong>di</strong>cal Sciences and Biotechnologies,<br />
School of Me<strong>di</strong>c<strong>in</strong>e, University of Brescia, 25123 Brescia, Italy<br />
33. GUANOSINE BINDING STUDIES IN RAT BRAIN MEMBRANES AND S.A.R.<br />
ANALYSIS FOR THE DESIGN OF A PHARMACOPHORE<br />
Palmieri C 1 ., Bombi G. 1 , Costant<strong>in</strong>o G. 2 , Pellicciari R. 2 , Traversa U. 1<br />
1 Dipartimento <strong>di</strong> Scienze Biome<strong>di</strong>che, <strong>Università</strong> <strong>di</strong> Trieste; via L. Giorgieri 7, 34127<br />
Trieste 2 Dipartimento <strong>di</strong> Chimica e Tecnologia del Farmaco, <strong>Università</strong> <strong>di</strong> Perugia,<br />
piazza dell’<strong>Università</strong> 1, 06100 Perugia<br />
34. MOLECULAR DETERMINANTS OF METABOTROPIC GLUTAMATE<br />
RECEPTOR 4 SIGNALLING AND REGULATION.<br />
Iacovelli L. 1 ,2 , Iula M. 1 , Capobianco L. 2 , Picascia A. 2 , De Blasi A. 2 1 ,2<br />
, Nicoletti F.<br />
1<br />
Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”, Italy; 2 INM Neuromed, Pozzilli, Italy<br />
35. P2Y2 RECEPTOR mRNA UPREGULATION INDUCED BY GUANOSINE OR<br />
BENZOYLBENZOYLATP (BzATP) IN RAT BRAIN CULTURED ASTROCYTES<br />
Buccella S., Nargi E., D’Auro M., Di Iorio P., Ciccarelli R., Caciagli F., Baller<strong>in</strong>i P.<br />
Dept. of Biome<strong>di</strong>cal Sciences, “G. D’Annunzio” University, Chieti, Italy<br />
33<br />
Abs. book<br />
page<br />
5<br />
146<br />
62<br />
21<br />
125<br />
102<br />
74<br />
18
Poster<br />
n°<br />
36. PHARMACOLOGICAL ACTIVATION OF mGlu3 and mGlu4 METABOTROPIC<br />
GLUTAMATE RECEPTORS INCREASES CELL PROLIFERATION OF HUMAN<br />
MEDULLOBLASTOMA CELL LINES<br />
Arcella A 1 ., D’Onofrio M. 1 , Ngomba RT 1 , Battaglia G. 1 , Bruno V. 1 ,2 , Nicoletti F 1<br />
,2 , Giangaspero F 1 ,3 .<br />
1 I.N.M. Neuromed, Pozzilli, Italy; 2 Department of Human Physiology and<br />
Pharmacology, University of Rome “La Sapienza”, Rome, Italy; 3 Department of<br />
Experimental Me<strong>di</strong>c<strong>in</strong>e and Pathology, University of Rome “La Sapienza”, Rome, Italy<br />
37. PHARMACOLOGICAL BLOCKADE OF mGlu2/3 GLUTAMATE RECEPTORS<br />
REDUCES CELL PROLIFERATION OF HUMAN GLIOMA CELLS IN VITRO AND<br />
IN VIVO<br />
D’Onofrio M. 1 , Arcella A. 1 , Bruno V. 1 , 2 , Ngomba RT 1 , Battaglia G 1 ., Giangaspero<br />
F 1 ,3 , Nicoletti F 1 , 2 .<br />
1 I.N.M. Neuromed, Pozzilli, Italy; 2 Department of Human Physiology and<br />
Pharmacology, University of Rome “La Sapienza”, Rome, Italy; 3 Department of<br />
Experimental Me<strong>di</strong>c<strong>in</strong>e and Pathology, University of Rome “La Sapienza”, Rome, Italy<br />
38. PHARMACOLOGICAL HETEROGENEITY OF NATIVE AMPA/KAINATE<br />
RECEPTORS PRESYNAPTICALLY LOCATED ON RAT BRAIN ISOLATED<br />
NERVE ENDINGS AS REVEALED BY RECEPTOR ANTAGONISTS<br />
Feligioni M. 1 , Segant<strong>in</strong>i D. 1 , Bonfanti A. 1 , Pittaluga A. 1 , 2 , Raiteri M.<br />
1 Sezione <strong>di</strong> Farmacologia e Tossicologia, Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sprerimentale,<br />
<strong>Università</strong> <strong>di</strong> Genova, Italia. 2 Centro <strong>di</strong> Eccellenza per la ricerca Biome<strong>di</strong>ca, <strong>Università</strong><br />
<strong>di</strong> Genova, Genova, Italia<br />
39. REDUCED ACTIVITY OF HIPPOCAMPAL GROUP-I METABOTROPIC<br />
GLUTAMATE RECEPTORS IN LEARNING-PRONE RATS<br />
C<strong>in</strong>que C. 1 , Zuena A.R. 1 , Casol<strong>in</strong>i P. 1 , Ngomba R.T. 2 , Melchiorri D. 1 , Maccari S. 3 ,<br />
Nicoletti F. 1 , 2 , Catalani A. 1<br />
1 Dept. of Human Physiol. and Pharmacol., University of Rome “La Sapienza”, P.le A.<br />
Moro 5, I-00185, Rome, Italy; 2 I.N.M. Neuromed, Pozzilli, Italy; 3 Lab. of<br />
Neuroscience, Université de Lille 1, France<br />
40. EFFECT OF CHRONIC TREATMENT WITH NICOTINE ON THE SENSITIVITY<br />
OF PRESYNAPTIC NMDA AND AMPA RECEPTORS REGULATING [3H]-NA<br />
AND [3H]-DA RELEASE<br />
Risso F., Grilli M., Molf<strong>in</strong>o F., Raiteri M., Marchi M.<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Pharmacology and Toxicology Section,<br />
University of Genoa, Italy<br />
41. ROLE OF PRESYNAPTIC NICOTINIC AND NMDA RECEPTORS IN THE<br />
MODULATION OF NORADRENALINE RELEASE FROM HIPPOCAMPAL<br />
SYNAPTOSOMES<br />
Risso F., Paro<strong>di</strong> M., Bado M., Raiteri M., Marchi M.<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Pharmacology and Toxicology Section,<br />
University of Genoa, Italy<br />
34<br />
1 , 2<br />
Abs. book<br />
page<br />
3<br />
52<br />
55<br />
34<br />
119<br />
119
Poster<br />
n°<br />
42. SENSITIVITY CHANGES OF ENTERIC CHOLINERGIC NEURONS TO m- AND k-<br />
OPIOID RECEPTOR AGONISTS AFTER CHRONIC SYMPATHETIC<br />
DENERVATION: ROLE OF PROTEIN KINASE C.<br />
D. Giuliani, E. Zanetti, L. Canciani, C. Giaroni, S. Lecch<strong>in</strong>i, G.M. Frigo<br />
Cl<strong>in</strong>ical and Applied Pharmacology Center University of Insubria and University of<br />
Pavia, Italy<br />
35<br />
Abs. book<br />
page<br />
70
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 2C<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia della trasmissione s<strong>in</strong>aptica centrale.<br />
POSTER 43-60<br />
Moderatore: A.M. De Luca (Bari)<br />
Poster<br />
n°<br />
43. ANALYSIS OF NITRIC OXIDE DONOR-INDUCED EFFECTS ON DOPAMINE<br />
RELEASE IN THE STRIATUM OF FREELY MOVING RATS: ROLE OF<br />
CALCIUM, IRON AND SOLUBLE GUANYLATE CYCLASE/CYCLIC GMP<br />
PATHWAY<br />
Pier Andrea Serra, Gaia Rocchitta, Maria R. Delogu, Rossana Migheli, Maria G.<br />
Taras, Maria P. Mura, Giovanni Esposito, Maddalena Miele, Egi<strong>di</strong>o Miele, Maria S.<br />
Desole<br />
Department of Pharmacology, University of Sassari, 07100 Sassari<br />
44. ANTINOCICEPTIVE PROFILE OF (-)LINALOOL IN THE INTRAPLANTAR<br />
FORMALIN TEST AND HOT-PLATE PAIN MODELS<br />
Peana A.T., De Montis M.G., Nieddu E., Chessa G., D’Aquila P.S., Pippia P. 1<br />
Dipartimento <strong>di</strong> Scienze del Farmaco, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Sassari, Sassari, Italy 1<br />
Dipartimento <strong>di</strong> Scienze Fisiologiche, Biochimiche e Cellulari, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong><br />
Sassari, Sassari, Italy<br />
45. BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) INTERNALIZATION AND<br />
ACTIVITY-DEPENDENT SECRETION IN HIPPOCAMPAL NEURONS<br />
Cappello S, Santi S., Riccio M, Shenk U, Matteoli M, Canossa M<br />
Department of Pharmacology, University of Bologna, via Irnerio 48, 40126 Bologna,<br />
Italy; Department of Pharmacology, University of Milano, via Vamvitelli 32, Milano,<br />
Italy; ITOI (CNR) via <strong>di</strong> Barbiano 1/10 40136 Bologna, Italy<br />
46. EFFECT OF NOCICEPTIN (n/ofq) ON GLUTAMATE AND GABA RELEASE AND<br />
ON CELL EXCITABILITY IN PRIMARY CULTURES OF RAT CORTICAL<br />
NEURONS<br />
Bianchi C., Marani L., Barbieri M., Mar<strong>in</strong>o S., Beani L., S<strong>in</strong>iscalchi A.<br />
Dept. of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e: Section of Pharmacology, and<br />
Neuroscience Center, University of Ferrara, via Fossato <strong>di</strong> Mortara 17-19, Ferrara, Italy<br />
47. EFFECTS OF CHRONIC NISOXETINE ON PRODYNORPHIN GENE<br />
EXPRESSION IN RAT CNS<br />
Di Benedetto M., D’Addario C., Feliciani D. Candeletti S., Romual<strong>di</strong> P.<br />
Dept. of Pharmacology, University od Bologna, Irnerio 48, 40126 Bologna, Italy<br />
36<br />
Abs. book<br />
page<br />
129<br />
106<br />
24<br />
12<br />
47
Poster<br />
n°<br />
48. ELECTROPHYSIOLOGICAL EFFECTS OF 4-AMINOPYRIDINE ON FICTIVE<br />
LOCOMOTOR ACTIVITY OF THE RAT SPINAL CORD IN VITRO<br />
Taccola G<br />
Biophysics sector, SISSA (Trieste)<br />
49. EXPRESSION AND BIOLOGICAL ACTIVITY OF B1 BRADYKININ RECEPTORS<br />
IN THE HIPPOCAMPUS OF KINDLED RATS<br />
M. Simonato 1 , D. Ro<strong>di</strong> 1 , G. Bregola 1 , S. Zucch<strong>in</strong>i 1 , A. B<strong>in</strong>aschi 1 , M. Mazzuferi 1 ,<br />
D. Regoli 1 , B. Ongali 2 , R. Couture 2<br />
1 Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology,<br />
University of Ferrara, 44100 Ferrara, Italy. 2 Department of Physiology, Faculty of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Montreal, Montreal, Quebec, Canada, H3C 3J7.<br />
50. FUNCTIONAL CONSEQUENCES OF A NOVEL HUMAN MUTATION IN<br />
GLYCINE RECEPTOR a1 SUBUNITS CAUSING HYPEREKPLEXIA<br />
1 Taglialatela M., 3 Stefanoni P., 1 Castaldo P., 2 Miraglia del Giu<strong>di</strong>ce E., 2 ,3 Bell<strong>in</strong>i G.,<br />
2 ,3 Coppola G., 2 ,3 Pascotto A., 1 Annunziato L.<br />
1 Div. Pharmacology, Dep. Neuroscience, School of Me<strong>di</strong>c<strong>in</strong>e, Univ. Naples Federico<br />
II; 2 Dept. Pe<strong>di</strong>atrics and 3 Chair of Child Neuropsychiatry, 2 nd Univ. Naples.<br />
51. GLIASOMES: PURIFIED GLIA PARTICLES THAT RELEASE GLUTAMATE BY<br />
A PROCESS RESEMBLING NEURONAL EXOCYTOSIS<br />
Stigliani S. 1 , Zappett<strong>in</strong>i S. 1 , Raiteri L. 1 , Passalacqua M. 2 , Raiteri M. 1 ;3 , Bonanno G.<br />
1 ;3<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e (DIMES) – Pharmacology and Toxicology<br />
section 1 and Biochemistry section 2 , University of Genova. Center of Excellence for<br />
Biome<strong>di</strong>cal Research (CEBR), University of Genova, Italy<br />
52. GROUP III mGlu RECEPTORS MODULATE PERIAQUEDUCTAL GREY<br />
GLUTAMATE AND GLYCINE RELEASE AND INCREASE THE<br />
THERMOCEPTIVE THRESHOLD IN RAT<br />
Marabese I., de Novellis V, Palazzo E., Genovese R., Mariani L., Vacca C., Rossi F.,<br />
Maione S.<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology “L. Donatelli”,<br />
Faculty of Me<strong>di</strong>c<strong>in</strong>e and Surgery, Second University of Naples, Via Costant<strong>in</strong>opoli, 16<br />
80138 Naples, Italy<br />
53. HIGH SENSITIVITY OF RAT BRAINSTEM MOTONEURONS TO NICOTINE<br />
Quitadamo M.C.<br />
Biophysics sector, S.I.S.S.A. (Trieste)<br />
54. INHIBITION OF CATECHOLAMINE RELEASE BY BOTULINUM TOXIN-<br />
INDUCED SNARE PROTEIN CLEAVAGE SUGGEST TARGETING OF VESICLES<br />
SET INTO THE READILY RELEASABLE POOL<br />
Zappett<strong>in</strong>i S. 1 , Raiteri L. 1 , Stigliani S. 1 , Raiteri M. 1 ,‡ ,Bonanno G.<br />
1 Department of Experimental Me<strong>di</strong>c<strong>in</strong>e (DIMES) - Section of Pharmacology and<br />
Toxicology University of Genova and ‡ Center of Excellence for Biome<strong>di</strong>cal Research<br />
(CEBR)- University of Genova- Italy<br />
37<br />
1 ,‡<br />
Abs. book<br />
page<br />
134<br />
130<br />
135<br />
133<br />
83<br />
115<br />
147
Poster<br />
n°<br />
55. KCNQ2 POTASSIUM CHANNELS MODULATE [ 3 H]NORADRENALINE<br />
RELEASE FROM HIPPOCAMPAL SYNAPTOSOMES<br />
Martire M., Taglialatela M. 1 , Castaldo P. 1 , D’Amico M., Annunziato L. 1<br />
Institute of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, Catholic University of S. Heart, Rome;<br />
1 Department of Neuroscience, School of Me<strong>di</strong>c<strong>in</strong>e, University of Naples Federico II,<br />
Naples<br />
56. LACK OF EVIDENCE FOR IN VIVO NO-MEDIATED CGMP SYNTHESIS BY<br />
NMDA RECEPTOR ACTIVATION IN THE CEREBRAL CORTEX OF FREELY-<br />
MOVING RATS<br />
Pepicelli O., Brescia A., Raiteri M., Fedele E.<br />
Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale, Sezione <strong>di</strong> Farmacologia e Tossicologia,<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Genova, Viale Cembrano 4, 16148 Genova<br />
57. MAPPING NICOTINIC RECEPTORS IN RAT HYPOGLOSSAL NUCLEUS<br />
Elsa Fabbretti<br />
Biophysics Sector, International School for Advanced <strong>Stu<strong>di</strong></strong>es (SISSA), 34014 Trieste,<br />
Italy<br />
58. MELATONIN AND DIURNAL CHANGES OF TONIC PAIN RESPONSES IN MICE<br />
Periss<strong>in</strong> L., Boccalon S., Scaggiante B., Ortolani F. 1 , Petrelli L. 1<br />
Dipartimento <strong>di</strong> Scienze e Tecnologie Biome<strong>di</strong>che and 1 Dipartimento <strong>di</strong> Scienze<br />
Me<strong>di</strong>che e Morfologiche, <strong>Università</strong> <strong>di</strong> Ud<strong>in</strong>e, P.le Kolbe 4, 33100 Ud<strong>in</strong>e, Italy<br />
59. REDUCED K + CHANNEL FUNCTION BY A NOVEL KCNQ2 MUTATION IN A<br />
PATIENT WITH BENIGN FAMILIAL NEONATAL CONVULSIONS FOLLOWED<br />
BY BENIGN EPILEPSY WITH CENTROTEMPORAL SPIKES<br />
1 Castaldo P., 1 Soldovieri M.V., 2 Miraglia del Giu<strong>di</strong>ce E., 2 ,3 Bell<strong>in</strong>i G., 2 ,3 Coppola<br />
G., 4 Sferro C., 2 ,3 Pascotto A., 1 Annunziato L., 1 Taglialatela M.<br />
1 Div. Pharmacology, Dep. Neuroscience, School of Me<strong>di</strong>c<strong>in</strong>e, Univ. Naples Federico<br />
II; 2 Dept. Pe<strong>di</strong>atrics and 3 Chair of Child Neuropsychiatry, 2 nd Univ. Naples; 4 Inst. Of<br />
Child Neuropsychiatry, Univ. of Mess<strong>in</strong>a<br />
60. THE SEIZURE-INDUCING EFFECTS OF HIGH SYSTEMIC DOSES OF GABAB<br />
ANTAGONISTS IN THE RAT: A COMPARISON OF CGP-56999 AND SCH-50911<br />
Morrone L.A. 1 , Rombola L. 1 , Richards D. 2 , Bagetta G. 1 and Bowery NG. 2<br />
1 Department of Pharmacobiology, University of Calabria, Arcavacata <strong>di</strong> Rende, 87036,<br />
Italy, 2 Department of Pharmacology, Me<strong>di</strong>cal School, University of Birm<strong>in</strong>gham, B15<br />
2TT, UK<br />
38<br />
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VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia e tossicologia comportamentale.<br />
POSTER 61-79<br />
Moderatore: M. Massi (Camer<strong>in</strong>o)<br />
Poster<br />
n°<br />
61. A NITRIC OXIDE-RELEASING DERIVATIVE OF GABAPENTIN, NCX 8001,<br />
POTENTLY ALLEVIATES NEUROPATHIC-LIKE BEHAVIOURS IN RATS<br />
AFTER SPINAL CORD AND PERIPHERAL NERVE INJURY<br />
Impagnatiello F., Bonazzi A., Presotto C., Xu X-J. 1 , Wiesenfeld-Hall<strong>in</strong> Z. 1 , Ong<strong>in</strong>i<br />
E.<br />
NicOx Research Institute, Bresso, Milan-Italy; 1 Dept. Me<strong>di</strong>cal Laboratory Science and<br />
Technology, Div. of Neurophysiology, Karol<strong>in</strong>ska Institute, Stockholm, Sweden<br />
62. BEHAVIOURAL CHANGES IN TRANSGENIC MICE EXPRESSING<br />
F3/CONTACTIN FROM TAG-1 PROMOTER<br />
Tattoli M. 1 , Coluccia A. 1 , Bizzoca A. 1 , Lorusso L. 1 , Arbia S. 1 , De Bene<strong>di</strong>ctis L. 1 ,<br />
Cuomo V. 2 , Gennar<strong>in</strong>i G. 1 , R. Cagiano 1 .<br />
1 Department of Pharmacology and Human Physiology, University of Bari; 2<br />
Department of Pharmacology and General Physiology, University “La Sapienza” Rome,<br />
Italy<br />
63. BOTH METHYLPHENIDATE AND ACETYL-L-CARNITINE REDUCE<br />
IMPULSIVITY IN ADOLESCENT SHRS, AN ANIMAL MODEL OF ADHD<br />
Adriani W. 1 ; Baviera M. 2 ; Invernizzi W. 2 ; Carli M. 2 ; Caprioli A. 3 ; Ghirar<strong>di</strong> O. 3 ;<br />
Laviola G. 1<br />
1 2<br />
Behavioral Pathophysiology, Lab FOS, Istituto Superiore <strong>di</strong> Sanità, Neuroscience,<br />
“Mario Negri” Institute; 3 Behavioral Pharmacology Lab, “Sigma-Tau” SpA, Pomezia,<br />
Italy<br />
64. EFFECT OF A BROMINATED FLAME RETARDANT (PBDE-99) ON<br />
NEUROBEHAVIORAL DEVELOPMENT IN MICE<br />
F. Capone 1,2 , G. Iaffaldano 2,3 , I. Branchi 2, L.G. Costa 3,4 , E. Alleva 2<br />
1 Dept. of Pharmacology of Natural Substances and General Physiology, University of<br />
Roma La Sapienza, Italy; 2 Lab. of Fisiopatologia <strong>di</strong> Organo e <strong>di</strong> Sistema, Istituto<br />
Superiore <strong>di</strong> Sanità, Roma, Italy; 3 Dept. of Pharmacology and Human Physiology,<br />
University of Bari Me<strong>di</strong>cal School, Italy, 4 Dept. of Environmental and Occupational<br />
Health Sciences, University of Wash<strong>in</strong>gton, Seattle, WA, USA<br />
39<br />
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n°<br />
65. EFFECT OF L-ACETYLCARNITINE ON METABOTROPIC GLUTAMATE<br />
RECEPTOR 2/3 EXPRESSION IN DORSAL ROOT GANGLIA CULTURED<br />
NEURONS<br />
1 Chiechio S., 2 Caricasole A, 1 Caraci F., 3 Storto M, 4 Catania MV, 1 Copani A, 5<br />
Vertechy M., 5 Nicolai R., 5 Calvani M, 2 Melchiorri D, 2 -3 Nicoletti F.<br />
1 Department of Pharmaceutical Sciences, University of Catania, Italy; 2 Department of<br />
Human Physiology and Pharmacology, University of Rome “La Sapienza”, Italy; 3<br />
I.N.M. Neuromed, Pozzilli, Italy; 4 I.B.S.N.C. C.N.R, Catania, Italy; 5 Sigma-Tau<br />
Laboratories, Pomezia, Italy<br />
66. EFFECTS OF ATYPICAL NEUROLEPTIC QUETIAPINE FUMARATE<br />
TREATMENT IN KO iNOS MICE AFTER EXPOSITION TO THE PORSOLT<br />
FORCED SWIMMING TEST<br />
Arbitrio M. 2 , Trombetta G. 1 , Costa N. 3 , Vecchio I. 2 , De Sarro G. 1 , Rotiroti D. 3<br />
1 Chair of Pharmacology, Department of Experimental Me<strong>di</strong>c<strong>in</strong>e- Faculty of Me<strong>di</strong>c<strong>in</strong>e<br />
and Surgery- University of Catanzaro "Magna Græcia”; 2 CNR-ISN, Section of<br />
Pharmacology, Catanzaro; 3 Chair of Pharmacology, Faculty of Pharmacy University of<br />
Catanzaro "Magna Græcia”<br />
67. EFFECTS OF CASTRATION ON PREPULSE INHIBITION IN WISTAR ADULT<br />
RATS<br />
Bortolato M., Frau R., Aru G.N., Orrù M., Gessa G.L.<br />
Department of Neuroscience “Bernard B. Bro<strong>di</strong>e”; Center of Excellence “Neurobiology<br />
of dependence”; University of Cagliari<br />
68. EFFECTS OF NEUROLEPTIC TREATMENT WITH QUETIAPINE FUMARATE<br />
ON IMMOBILITY TIME OF MICE IN THE PORSOLT FORCED SWIMMING<br />
TEST<br />
Trombetta G. 1 , Arbitrio M. 2 , Marra R. 2 , Iannone M. 2 , De Sarro G. 1 , Rotiroti D. 3<br />
1 Chair of Pharmacology, Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e- Faculty<br />
of Me<strong>di</strong>c<strong>in</strong>e and Surgery- University of Catanzaro "Magna Græcia”; 2 CNR-ISN,<br />
Section of Pharmacology, Catanzaro; 3 Chair of Pharmacology, Faculty of Pharmacy<br />
University of Catanzaro "Magna Græcia”<br />
69. MELATONIN IMPROVES BEHAVIOURAL RESPONSE ON FORCED<br />
SWIMMING TEST AND DECREASE NEURONAL DAMAGE AFTER PARAQUAT<br />
TREATMENT IN TWO MICE STRAINS<br />
Trombetta G. 3 , Arbitrio M. 1 ., Costa N. 2 ., Cuzzocrea S 4 ., Marra R 1 ., De Sarro G 3 .,<br />
Rotiroti D. 2 .<br />
1 CNR-ISN- Section of Pharmacology- Catanzaro; 2 Faculty of Pharmacy - University<br />
of Catanzaro "Magna Græcia,; 3 Chair of Pharmacology - Department of Experimental<br />
Me<strong>di</strong>c<strong>in</strong>e, Faculty of Me<strong>di</strong>c<strong>in</strong>e and Surgery - University of Catanzaro "Magna Græcia";<br />
4 Institute of Pharmacology, Faculty of Me<strong>di</strong>c<strong>in</strong>e and Surgery - University of Mess<strong>in</strong>a<br />
70. FERULA HERMONIS AND COPULATORY BEHAVIOR OF MALE RATS<br />
Zanoli P., Benelli A. 1 , Rivasi M., Vezzal<strong>in</strong>i F., Baral<strong>di</strong> M.<br />
Dept. of Pharmaceutical Sciences and 1 Dept. of Biome<strong>di</strong>cal Sciences, Section of<br />
Pharmacology, University of Modena and Reggio Emilia, Modena<br />
40<br />
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140<br />
147
Poster<br />
n°<br />
71. GG-146, A NEW SELECTIVE, NON BENZODIAZEPINIC ANXIOLYTIC<br />
DISCOVERED BY LIGHT/DARK CHOICE TEST IN MICE<br />
Malmberg-Aiello P. 1 , Br<strong>in</strong>i E. 1,2 , De Siena G. 1 , Birka I. 1 , Guerr<strong>in</strong>i G. 2 Costa B. 3 ,<br />
Mart<strong>in</strong>i C. 3 Costanzo A. 2<br />
1 Dipartimento <strong>di</strong> Farmacologia Precl<strong>in</strong>ica e Cl<strong>in</strong>ica, <strong>Università</strong> <strong>di</strong> Firenze, Viale G.<br />
Pieracc<strong>in</strong>i 6, 50139 Firenze; 2 Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong><br />
Firenze, Via G. Capponi 9, 50121 Firenze; 3 Dipartimento <strong>di</strong> Psichiatria, Neurobiologia,<br />
Farmacologia e Biotecnologie, <strong>Università</strong> <strong>di</strong> Pisa, Via Bonanno 6, 56126 Pisa<br />
72. INFLUENCE OF MIRTAZAPINE ON SEXUAL MOTIVATION AND<br />
PERFORMANCE IN MALE RATS.<br />
Benelli A., Frigeri C., 1 Bertol<strong>in</strong>i A., Poggioli R., Genedani S.<br />
Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology; 1 Department of Internal<br />
Me<strong>di</strong>c<strong>in</strong>e, Section of Toxicology and Cl<strong>in</strong>ical Pharmacology; via G.Campi 287, 1 Via<br />
del Pozzo 71, University of Modena and Reggio Emilia, 41100 MODENA, Italy<br />
73. INVOLVEMENT OF OP4 RECEPTOR/ORPHANIN FQ SYSTEM ON THE<br />
ANTINOCICEPTIVE TOLERANCE OF OPIOID IN MICE<br />
Di Giannuario A., Pieretti S.<br />
Department of Pharmacology, Istituto Superiore <strong>di</strong> Sanità V.le Reg<strong>in</strong>a Elena 299,<br />
00161 Roma, Italy<br />
74. MORPHINE INDUCES THE ACTIVATION OF THE ENZYME COX-2<br />
Far<strong>in</strong>a, R., 1 Micheli L., Sabat<strong>in</strong>o C., Milano W., Petrella C., Capasso A.<br />
Department of Pharmaceutical Sciences, University of Salerno Via Ponte Don Melillo<br />
(84084) Fisciano, Salerno and Department of Pharmacology "Giorgio Segre" University<br />
of Siena, Via delle Scotte 6 (53100) Siena<br />
75. ONTOGENY OF CHOLINERGIC MODULATION OF BEHAVIOR AND<br />
ULTRASONIC VOCALIZATION IN THE MOUSE (MUS MUSCULUS)<br />
Campolongo P. 1 , 2 , Branchi I. 1 , Alleva E. 1<br />
1 Laboratorio <strong>di</strong> Fisiopatologia <strong>di</strong> Organo e Sistema, Istituto Superiore <strong>di</strong> Sanita’, viale<br />
Reg<strong>in</strong>a Elena, 299, 00161 Roma, Italy; 2 Dipartimento <strong>di</strong> Farmacologia delle Sostanze<br />
Naturali e Fisiologia generale, Universita’ <strong>di</strong> Roma “La Sapienza”, p.le Aldo Moro, 5,<br />
00185 Roma, Italy<br />
76. PERINATAL EXPOSURE TO AZT AFFECTS JUVENILE SOCIAL<br />
INTERACTIONS AND ADULT SOCIAL/AGGRESSIVE BEHAVIOUR OF CD-1<br />
MICE<br />
Venerosi A. 1 , Cirulli F., Alleva E.<br />
Sections of 1 Comparative Psychology and Behavioural Pathophysiology, Laboratorio<br />
<strong>di</strong> Fisiopatologia <strong>di</strong> Organo e <strong>di</strong> Sistema, Istituto Superiore <strong>di</strong> Sanità, Viale Reg<strong>in</strong>a<br />
Elena, 299, I-00161 Rome, Italy<br />
77. PERIPHERAL NEUROPATHIC PAIN IN MICE: AN EXPERIMENTAL MODEL TO<br />
STUDY ANALGESICS<br />
Garrone B, Moreci W, De Santi S, Di Loreto G, 1 Pavone F, Guglielmotti A<br />
ACRAF SpA, S.Palomba-Pomezia, Rome, Italy; 1 Institute of Psychobiology and<br />
Psychopharmacology, CNR, Rome, Italy<br />
41<br />
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Poster<br />
n°<br />
78. USE OF AN EXPERIMENTAL MODEL OF PERIPHERAL NEUROPATHIC PAIN<br />
TO STUDY ANALGESICS IN RATS<br />
Garrone B, Moreci W, De Santi S, Di Loreto G, Guglielmotti A<br />
ACRAF SpA, S.Palomba-Pomezia, Rome, Italy<br />
79. RELATIONSHIP BETWEEN STRESS, LEARNING AND HIPPOCAMPAL BRAIN-<br />
DERIVED NEUROTROPHIC FACTOR<br />
Del Bianco P. 1 , Scaccianoce S. 1 , Caricasole A. 2 , Nicoletti F. 1 , Catalani A. 1<br />
Department of Human Physiology and Pharmacology “Vittorio Erspamer”, University<br />
of Rome “La Sapienza”, Rome Italy 1 and Siena Biotech SpA , Siena Italy 2<br />
42<br />
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42
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia dei <strong>di</strong>sord<strong>in</strong>i neurologici e psichiatrici.<br />
POSTER 80-97<br />
Moderatore: F. Pedata (Firenze) – C. Bianchi (Ferrara)<br />
Poster<br />
n°<br />
80. ADAPTIVE CHANGES IN THE ACTIVATION OF HIPPOCAMPAL a-CaM<br />
KINASE II INDUCED BY CHRONIC BLOCKADE OF NORADRENALINE<br />
REUPTAKE<br />
Tiraboschi E 1 , D' Urso G. 2 , Celano E 1 , Tar<strong>di</strong>to D 1 , de Bartolomeis A 2 , Gennarelli<br />
M 3 , Racagni 1 ,3 G, Popoli M 1 .<br />
1 Center of Neuropharmacol. Dept Pharmacol. Sciences, University of Milano; 2 Dept<br />
of Neurosciences and Behavioural Science, University Federico II, Napoli; 3 Genetic<br />
Unit, IRCCS Centro San Giovanni <strong>di</strong> Dio-FBF, Brescia (Italy)<br />
81. ANTIDEPRESSANT DRUGS AND INHIBITION OF THE SEROTONIN<br />
TRANSPORTER (SERT): COMPARISON BETWEEN HUMAN AND RAT USING<br />
AN IN VITRO FUNCTIONAL UPTAKE ASSAY<br />
Benedetti R., Cavall<strong>in</strong>i P., Zumerle A., Faedo S., Remelli R., Thomas D.R. 1 , Hill M. 1 ,<br />
Atk<strong>in</strong>son P.A 1 , Watson J.M. 1 , Corsi M., Cavanni P.<br />
Center of Excellence for Drug Discovery, Psychiatry, Verona & Harlow -<br />
GlaxoSmithKl<strong>in</strong>e SpA, Me<strong>di</strong>c<strong>in</strong>es Research Center, via Flem<strong>in</strong>g n.4, 37135 Verona,<br />
Italy. 1 New Frontiers Science Park (North), Cold Harbour Road, Harlow, Essex, CM19<br />
5AW, UK<br />
82. CARBENOXOLONE EXERTS ANTICONVULSANT ACTIVITY IN<br />
GENETICALLY EPILEPSY PRONE RATS<br />
Gareri P. 1 , 2 , Condorelli D.F. 2 , Trovato Sal<strong>in</strong>aro A. 2 , Barresi V. 2 , Citraro R. 1 ,<br />
Mudò G. 3 , Belluardo N. 3 , De Sarro G. 1<br />
1 Chair of Pharmacology, Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e,<br />
University of Catanzaro “Magna Graecia”, 2 Section of Biochemistry and Molecular<br />
Biology, Department of Chemical Sciences, University of Catania and 3 DIMES, Div. of<br />
Human Physiology, Lab. Molecular Neurobiology, University of Palermo, Italy<br />
83. CENTRAL NERVOUS SYSTEM LOCALIZATION AND CHANGES OF GENE<br />
EXPRESSION PROFILE IN NEUROPATHIC RATS SUPPORT A ROLE FOR<br />
MELANOCORTIN SYSTEM IN NOCICEPTION<br />
Campanella M., Tarozzo G. Fredduzzi S., Forlani A., Bertorelli R., Beltramo M.,<br />
Reggiani A.<br />
Scher<strong>in</strong>g-Plough Research Institute, San Raffaele Science Park, Via Olgett<strong>in</strong>a 58,<br />
20132 Milan, Italy<br />
43<br />
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10<br />
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Poster<br />
n°<br />
84. EFFECT OF LONG-TERM CARBAMAZEPINE TREATMENT ON A MODEL OF<br />
MANIA IN RATS<br />
Nanni G., Masi F., Grappi S., Gambarana C., De Montis M.G. 1 ., Tagliamonte A.<br />
Department of Neuroscience, University of Siena; 1 Department of Drug Sciences,<br />
University of Sassari<br />
85. EFFECTS OF IMMOBILIZATION STRESS ON THE HIPPOCAMPUS OF<br />
TRANSGENIC MICE EXPRESSING TYPE II GLUCOCORTICOID RECEPTOR<br />
ANTISENSE RIBONUCLEIC ACID.<br />
Alboni S. 1 , Ferraguti C 1 , V<strong>in</strong>et J 1 , Benatti C. 1 , Avvantaggiato E. 1 ., Brunello N. 1 .,<br />
Tascedda F. 1 ., Blom J.M.C 2<br />
1 Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Modena e Reggio Emilia, Via<br />
Campi 183, Modena, Italia; 2 Dipartimento <strong>di</strong> Psicologia, <strong>Università</strong> Vita-Salute San<br />
Raffaele, Via Olgett<strong>in</strong>a 58, Milano, Italia<br />
86. EFFECTS OF TOPIRAMATE IN VARIOUS GENETIC ANIMAL MODELS OF<br />
EPILEPSY<br />
1 De Sarro G, 1 Ferreri G, 1 S<strong>in</strong>iscalchi A, 2 Marra R, 3 Palma E, 1 Donato <strong>di</strong> Paola E, 1<br />
Russo E<br />
1 Cattedra <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale e Cl<strong>in</strong>ica, 3 Facoltà<br />
<strong>di</strong> Farmacia, <strong>Università</strong> “Magna Graecia” Catanzaro, Italia; 2 CNR Istituto <strong>di</strong> Scienze<br />
Neurologiche, sezione <strong>di</strong> Catanzaro, Italia<br />
87. FURTHER EVIDENCE FOR THE ANXIOLYTIC – LIKE PROFILE OF THE<br />
ATYPICAL ANTIPSYCHOTIC CLOZAPINE IN MICE<br />
de Angelis L.<br />
Department of Biome<strong>di</strong>cal Sciences, University of Trieste, I-34127 Trieste<br />
88. GLIA –VESSEL INTERACTIONS: POSSIBLE MODULATION OF CEREBRAL<br />
VASCULAR TONE<br />
Chisari M., Sort<strong>in</strong>o M.A., Salomone S.<br />
Department of Experimental and Cl<strong>in</strong>ical Pharmacology, University of Catania<br />
89. IN VITRO AND IN VIVO EFFECTS OF ZP120 IN WILD TYPE AND<br />
NOCICEPTIN/ORPHANIN FQ RECEPTOR KNOCK OUT MICE<br />
Carrà G, Rizzi A, Gavioli EC, Zucch<strong>in</strong>i S, Regoli D, 1 Larsen BD, 1 Petersen JS, Calò<br />
G.<br />
Dept. Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e – Section of Pharmacology, University of<br />
Ferrara, 44100 Ferrara, Italy and 1 Zealand Pharma A/S, DK-2600 Glostrup, Denmark<br />
90. MELANOCORTIN AGONISTS AND ANTAGONISTS MODULATE<br />
NOCICEPTIVE SENSITIVITY IN THE FORMALIN TEST IN MICE<br />
Bertorelli R., Bellasio S., Nicolussi E., Reggiani A.<br />
Scher<strong>in</strong>g-Plough Research Institute, San Raffaele Science Park, Via Olgett<strong>in</strong>a, 58,<br />
20132 Milan, Italy<br />
91. NIFEDIPINE AFFECTS THE ANTICONVULSANT ACTIVITY OF TOPIRAMATE<br />
IN VARIOUS GENETIC ANIMAL MODELS OF EPILEPSY<br />
1 Russo E., § Constanti A., 1 Ferreri G., 1 Costa N., 1 Donato <strong>di</strong> Paola E., 1 De Sarro G.<br />
1 Cattedra <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale e Cl<strong>in</strong>ica,<br />
<strong>Università</strong> “Magna Graecia” Catanzaro, Italia. § Pharmacology Department, School of<br />
Pharmacy, University of London, England, UK<br />
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n°<br />
92. PRELIMINARY RESULTS OF A RANDOMIZED CLINICAL TRIAL ON<br />
ELEUTHEROCOCCUS SENTICOSUS FLUID EXTRACT EFFECTS ON ELDERLY<br />
QUALITY OF LIFE<br />
Cicero AFG 1 , Derosa G. 2<br />
1 Atherosclerosis Study Centre “GC Descovich” – Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Applied<br />
Biotechnology Dept. “D. Campanacci” – University of Bologna; 2 Department of<br />
Internal Me<strong>di</strong>c<strong>in</strong>e and Therapeutics, University of Pavia, Italy<br />
93. PYRROLIDINE DITHIOCARBAMATE (PDTC) REDUCES NEURONAL DAMAGE<br />
AFTER SPINAL CORD INJURY IN RATS<br />
Tiziana Genovese, Rosanna DiPaola, Salvatore Cardali, Alfredo Conti, Salvatore<br />
Cuzzocrea, Achille P. Caputi<br />
94. REGULATION OF CREB IN THE RAT CNS AFTER COMBINED TREATMENT<br />
WITH THE ANTIDEPRESSANT FLUOXETINE AND THE ATYPICAL<br />
ANTIPSYCHOTIC DRUG OLANZAPINE<br />
Ferraguti C. 1 , Capone G. 1 , Alboni S. 1 , Blom J. M. C. 2 , Tascedda F. 1 , Brunello N. 1<br />
1 Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Modena e Reggio Emilia, Via<br />
Campi 183, Modena, Italia; 2 Dipartimento <strong>di</strong> Psicologia, <strong>Università</strong> Vita-Salute San<br />
Raffaele, Via Olgett<strong>in</strong>a 58, Milano, Italia<br />
95. SEROTONIN AND CITALOPRAM LEVELS IN PLASMA AND PLATELETS<br />
AFTER CITALOPRAM ADMINISTRATION IN DEPRESSIVE PATIENTS<br />
Blar<strong>di</strong> P., Urso R. 1 , De Lalla A., Auteri A., Dell’Erba A. 2 , Castrogiovanni P. 2<br />
Center of Cl<strong>in</strong>ical Pharmacology, Department of Internal Me<strong>di</strong>c<strong>in</strong>e, University of<br />
Siena; 1 Department of Pharmacology “Giorgio Segre”, University of Siena; 2<br />
Department of Neuroscience/Psychiatry, University of Siena<br />
96. THE ACTIVATION OF GLUCOCORTICOID SYSTEM THAT FOLLOWS ACUTE<br />
STRESSOR EXPOSURE IS BLOCKED BY a-MSH<br />
Spaccamiglio A., Abbadessa G., Cangemi L 1 ., Esculapio P 1 ., Portaleone P 1 ., Racca<br />
S., Di Carlo F.<br />
Dipartimento <strong>di</strong> Scienze Cl<strong>in</strong>iche e Biologiche and 1 Dipartimento <strong>di</strong> Anatomia,<br />
Farmacologia e Me<strong>di</strong>c<strong>in</strong>a Legale, <strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o<br />
97. TOPIRAMATE AND ACETAZOLAMIDE INDUCE A SLOW<br />
HYPERPOLARIZATION OF RAT OLFACTORY CORTICAL NEURONES IN<br />
VITRO, VIA A NON-CARBONIC ANHYDRASE INHIBITORY MECHANISM<br />
1 Russo E., 2 Constanti A.<br />
2 Pharmacology Department, School of Pharmacy, University of London, England, UK.<br />
1 Cattedra <strong>di</strong> Farmacologia, Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale e Cl<strong>in</strong>ica,<br />
<strong>Università</strong> “Magna Graecia” Catanzaro, Italia<br />
45<br />
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131<br />
122
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Immunofarmacologia.<br />
POSTER 98-121<br />
Moderatori: G. Lombar<strong>di</strong> (Novara) - F. Tedesco (Trieste)<br />
Poster<br />
n°<br />
98. ACTIVATION OF SIGNAL TRANSDUCTION PATHWAY LEADING TO<br />
CHEMOTAXIS IN HUMAN NEUTROPHILS BY A “PURE”<br />
CHEMOATTRACTANT<br />
Falzarano S. 1 , Spisani S. 1 , Traniello S. 1 , Nall M.I 2 , , Selvatici R.<br />
1 Dipartimento <strong>di</strong> Biochimica e Biologia Molecolare, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Ferrara,<br />
2 Istituto <strong>di</strong> Chimica Biomolecolare CNR c/o Dipartimento <strong>di</strong> <strong>Stu<strong>di</strong></strong> Farmaceutici,<br />
<strong>Università</strong> <strong>di</strong> Roma "La Sapienza”, c Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale e<br />
Diagnostica, Sezione Genetica Me<strong>di</strong>ca, e 4 Centro <strong>di</strong> Neuroscienze, <strong>Università</strong> <strong>degli</strong><br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> Ferrara<br />
99. ADVANTAGES OF THE TREATMENT WITH MYCOPHENOLATE MOFETIL IN<br />
RENAL TRANSPLANTATION<br />
Scannav<strong>in</strong>i P. 1 ., Bonucchi D. 2 , Di Felice A 2 , Rossi T. 3 , P<strong>in</strong>i L.A. 1 .<br />
1 Cl<strong>in</strong>ical Pharmacology Unit, Department of Me<strong>di</strong>c<strong>in</strong>e and Me<strong>di</strong>cal Specialities and 2<br />
100.<br />
101.<br />
102.<br />
Center of Nephrology, Dialysis and Kidney Transplantation, Via del Pozzo 71, Modena.<br />
3 Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia,<br />
Via G. Campi 183 41100, Modena, Italy<br />
BENEFICIAL EFFECTS OF A NEW IMMUNOMODULATOR AGENT 3-(2-<br />
ETHYLPHENYL)-5-(3-METHOXYPHENYL)-1H-1,2,4-TRIAZOLE (ST 1959) IN<br />
TNBS-INDUCED COLITIS IN RATS<br />
M.A. Stasi, A. Ursillo, R. Taurelli, M. Aglianò 1 , P. Lorenzoni 1 , V. Ruggiero, L.<br />
Pacifici, V. Sorrent<strong>in</strong>o 1 , P. Carm<strong>in</strong>ati<br />
General Pharmacology Dept, R&D Sigma Tau SpA, Pomezia Italy 1 Molecular<br />
Me<strong>di</strong>c<strong>in</strong>e Section, department of Neuroscience; University of Siena<br />
CALCIUM ANTAGONISTS AND FUNCTIONAL ACTIVITY OF<br />
POLYMORPHONUCLEAR LEUKOCYTES<br />
Boscaro V., Cassone M.C.<br />
Dip. Anatomia, Farmacologia e Me<strong>di</strong>c<strong>in</strong>a Legale – sez. Farmacologia e Farmacognosia<br />
– <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Tor<strong>in</strong>o<br />
CYCLOSPORINE C2 MONITORING AFTER MORNING AND EVENING DOSE<br />
IN LIVER TRANSPLANTED PATIENTS<br />
Baraldo M., Franceschi L., Pavan F., Brollo L., Di Qual E., Furlanut M.<br />
Chair of Pharmacology, DPMSC, School of Me<strong>di</strong>c<strong>in</strong>e, University of Ud<strong>in</strong>e, Ud<strong>in</strong>e,<br />
Italy<br />
46<br />
3 ,4<br />
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page<br />
54<br />
127<br />
132<br />
15<br />
6
Poster<br />
n°<br />
103.<br />
104.<br />
105.<br />
106.<br />
107.<br />
108.<br />
109.<br />
110.<br />
111.<br />
CYTOKINE-DEPEDENT AND -INDEPENDENT PATHWAYS OF LPS-INDUCED<br />
MONOCYTE PGE2 BIOSYNTHESIS<br />
Ricciotti E., § Pistritto G., Sciulli M.G., Patrignani P.<br />
Department of Me<strong>di</strong>c<strong>in</strong>e & Ag<strong>in</strong>g, “G. d’Annunzio” University, Chieti, and § Tor<br />
Vergata University, Rome, Italy<br />
DOPAMINE INHIBITS PROTEIN KINASE C-INDUCED TYROSINE<br />
HYDROXILASE mRNA EXPRESSION IN HUMAN LYMPHOCYTES THROUGHT<br />
ACTIVATION OF DOPAMINERGIC D1-LIKE RECEPTORS<br />
Ferrari M, Cosent<strong>in</strong>o M., Mar<strong>in</strong>o F., Bombelli R., Ras<strong>in</strong>i E., Lecch<strong>in</strong>i S., Frigo G.M.<br />
Laboratory of Pharmacology, Center for Research <strong>in</strong> Cl<strong>in</strong>ical and Applied<br />
Pharmacology, University of Insubria and University of Pavia, Varese, Italy<br />
EFFECT OF INDINAVIR USED ALONE OR IN DOUBLE OR TRIPLE<br />
COMBINATION WITH AZT AND ddC ON HUMAN IMMUNE FUNCTIONS<br />
Mattioli B., Giordani L., Quaranta M.G., Viora M.<br />
Department of Immunology Istituto Superiore <strong>di</strong> Sanità, Rome, Italy<br />
EFFECT OF LEPTIN ON INDUCIBLE NITRIC OXIDE SYNTHASE IN TH-1<br />
CYTOKINE STIMULATED C6 CELLS<br />
Coppola A., Mattace Raso G., Pacilio M., Esposito E., Di Carlo R., Meli R.<br />
Department of Experimental Pharmacology, University of Naples Federico II<br />
EXTREMELY LOW FREQUENCY MAGNETIC FIELDS DIFFERENTLY<br />
INFLUENCE HUMAN MONOCYTE MIGRATION IN VITRO<br />
Salt<strong>in</strong>i S., Filaferro M, Galantucci M., Ottani A., Genedani S.<br />
Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, University of Modena<br />
and Reggio Emilia, Via Campi 287, I 41100 Modena, Italy<br />
GLIADIN INCREASES INOS PROTEIN EXPRESSION IN ACTIVATED<br />
MACROPHAGES<br />
De Stefano D, Maiuri MC, 1 Greco L, Carnuccio R<br />
Department of Experimental Pharmacology, 1 Department of Pe<strong>di</strong>atrics, University of<br />
Naples “Federico II”<br />
GLUCOCORTICOID RECEPTOR-NITRIC OXIDE CROSSTALK AND PRO-<br />
INFLAMMATORY CYTOKINE GENE EXPRESSION: IMPLICATIONS FOR<br />
RESISTANCE/VULNERABILITY TO ENCEPHALOMYELITIS<br />
1 L’ Episcopo F , 1 Morale MC, 1 Caniglia S, 1 Testa N, 1 Tirolo C, 1 Gennuso F, 2<br />
Scoto G, 1 3 Marchetti B.<br />
1 Neuropharmacol. OASI, Tro<strong>in</strong>a, Italy, 2 Dept. Pharmacol. Fac. of Pharmacy, Univ. of<br />
Catania, and 3 Dept. Pharmacol. Fac. of Me<strong>di</strong>c<strong>in</strong>e, Univ. of Sassari, Italy<br />
GRANULOCYTE-MACROPHAGE-COLONY-STIMULATING-FACTOR AND<br />
VERY LOW DOSE SUBCUTANEOUS INTERLEUKIN-2 FOR THE<br />
IMMUNOLOGICAL TREATMENT OF ADVANCED RENAL CELL CARCINOMA<br />
1 2 2 2 1 2<br />
Correale P., Nenc<strong>in</strong>i C., M. La Placa, Micheli L., Franc<strong>in</strong>i G., Giorgi G.<br />
1 2<br />
Dipartimento <strong>di</strong> Patologia Umana ed Oncologia, Dipartimento <strong>di</strong> Farmacologia<br />
“Giorgio Segre”, <strong>Università</strong> <strong>di</strong> Siena, 53100, Siena<br />
INHIBITORY EFFECT OF SOMATOSTATIN ANALOGUE SMS 201-995 ON IL-10<br />
SECRETION IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES<br />
Casnici C., Lattuada D., Cattaneo L., Marelli O.<br />
Dept. of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, University of Milan<br />
47<br />
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page<br />
117<br />
56<br />
88<br />
37<br />
124<br />
46<br />
77<br />
38<br />
27
Poster<br />
n°<br />
112.<br />
113.<br />
114.<br />
115.<br />
116.<br />
117.<br />
118.<br />
119.<br />
LYSOZYME IMMUNOSTIMULATION WITH CHITOSAN - ALGINATE<br />
MICROCAPSULES IN THE GUT ASSOCIATED LYMPHOID TISSUE<br />
L. Zorz<strong>in</strong> 1 , A. Marcuzzi 1 , K. Parenzan 2 , E. Francesch<strong>in</strong>is 3 , D. Vojnovic 3 , G. Sava 1<br />
1 2<br />
Fnd. C. e D. Callerio Onlus, Istitute of Biological Research; A. S. S., Forensic<br />
Toxicology Laboratory, Dept. of Public-Health ; 3 Dept. <strong>di</strong> Pharmaceutical Sciences,<br />
University of Trieste<br />
MITOCHONDRIAL ANTIOXIDANT PATTERN IN LIVERS FROM RATS AFTER<br />
LONG-TERM TREATMENT WITH CYCLOSPORINE A<br />
Bompadre S. 1 , Pugnaloni A. 2 , Politi A. 1 , Rub<strong>in</strong>i C. 3 , Ferreiro M.S. 4 , Gallardo I. 5 ,<br />
Bullon P. 5 , Batt<strong>in</strong>o M. 6<br />
1 Institute of Microbiology and Biome<strong>di</strong>cal Sciences,<br />
48<br />
6 Institute of Biochemistry,<br />
Institute of Human Morphology, 3 Istituto <strong>di</strong> Anatomia Patologica, 4 Institute of<br />
Infective Diseases and Public Health, <strong>Università</strong> politecnica delle Marche, Ancona<br />
ITALY, 5 Departamento de Estomatologia, Universidad de Sevilla, SPAIN.<br />
MODULATION OF SOMATOSTATIN RECEPTOR ON PHA ACTIVATED<br />
HUMAN LYMPHOCYTES<br />
Lattuada D., Casnici C., Cattaneo L., Marelli O.<br />
Dept. of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, University of Milan<br />
nF-kB IS ACTIVATED IN INTESTINAL MUCOSA OF COELIAC PATIENTS<br />
Maiuri MC, De Stefano D, 1 Greco L, Carnuccio R<br />
Department of Experimental Pharmacology, 1 Department of Pe<strong>di</strong>atrics, University of<br />
Naples “Federico II”<br />
OPPOSITE EFFECTS OF INTERLEUKINS –1 AND –18 ON THE<br />
NEUROENDOCRINE REGULATION OF STRESS AXIS<br />
Tr<strong>in</strong>gali G, Pozzoli G, Vairano M, Proietti A, Navarra P<br />
Institute of Pharmacology, Catholic University School Me<strong>di</strong>c<strong>in</strong>e, Rome, Italy<br />
ROSIGLITAZONE A LIGANDS OF THE PEROXISOME PROLIFERATOR-<br />
ACTIVATED RECEPTOR-G (PPAR-G), REDUCE THE EVOLUTION OF MURINE<br />
TYPE II COLLAGEN-INDUCED ARTHRITIS<br />
Salvatore Cuzzocrea, Emanuela Mazzon, Laura Dugo, Nimesh S.A. Patel, Ivana<br />
Serra<strong>in</strong>o, Rosanna Di Paola, Tiziana Genovese, Domenico Britti, Achille P. Caputi,<br />
Christoph Thiemermann<br />
TACHYKININ RECEPTORS DETECTED ON HUMAN ENDOTHELIAL CELLS<br />
Dianzani C., Coll<strong>in</strong>o M., Fantozzi R.<br />
Dip. Anatomia, Farmacologia e Me<strong>di</strong>c<strong>in</strong>a Legale, Univ. Tor<strong>in</strong>o<br />
TH1-TH2 RESPONSE IN HYPERPROLACTINEMIC MICE INFECTED WITH<br />
SALMONELLA ENTERICA SEROVAR TYPHIMURIUM<br />
Mattace Raso G. 1 , Meli R. 1 , Bentivoglio C. 2 , Nuzzo I. 2 , Pacilio M 1 , Gal<strong>di</strong>ero M. 2 ,<br />
Gal<strong>di</strong>ero E. 2 , Romano Carratelli C. 2 , Di Carlo R. 1<br />
1 2<br />
Department of Experimental Pharmacology, University of Naples Federico II and<br />
Institute of Microbiology, II University of Naples, Naples, Italy<br />
Abs. book<br />
page<br />
2<br />
148<br />
14<br />
76<br />
81<br />
140<br />
40<br />
47<br />
88
Poster<br />
n°<br />
120.<br />
121.<br />
THE EFFECT OF TRICARBONYL-DICHLORORUTHENIUM (II) DYMER ([RU-<br />
(CO3)-CL2]2) ON THE IMMUNOLOGICAL ACTIVATION OF GUINEA PIG MAST<br />
CELLS AND HUMAN BASOPHILS<br />
Vannacci A., Di Felice A., Giann<strong>in</strong>i L., Marzocca C., Pierpaoli S., Zagli G., Mas<strong>in</strong>i E.,<br />
Mannaioni P.F.<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, Me<strong>di</strong>cal Toxicology Unit, Viale<br />
Pieracc<strong>in</strong>i, 6, 50139 Firenze<br />
THE SUPEROXIDE DISMUTASE MIMETIC M40403 PREVENTS ANTIGEN-<br />
INDUCED BRONCHOCONSTRICTION IN A GUINEA PIG MODEL OF<br />
ALLERGIC ASTHMA<br />
Pierpaoli S., Vannacci A., Di Felice A., Giann<strong>in</strong>i L., Marzocca C., Zagli G., Mannaioni<br />
P.F., Bani D., Salvem<strong>in</strong>i D., Mas<strong>in</strong>i E.<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, Me<strong>di</strong>cal Toxicology Unit, Viale<br />
Pieracc<strong>in</strong>i, 6, 50139 Firenze<br />
49<br />
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VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Tossicologia sperimentale e cl<strong>in</strong>ica.<br />
POSTER 122-137<br />
Moderatore: P.F. Mannaioni (Firenze)<br />
Poster<br />
n°<br />
122. AUTOFLUORESCENCE SPECTROSCOPY AS NON-CONVENTIONAL<br />
TECHNIQUE TO STUDY LIVER RESPONSE DURING TRANSPLANTATION<br />
Vairetti M., Bertone R. 2 , Ferrigno A., Bottiroli G. 1 , Croce A.C. 1 , Fiorani S. 1 ,<br />
Richelmi P., Neri D. 3 , Freitas I. 2<br />
Dept. of Internal Me<strong>di</strong>c<strong>in</strong>e & Therapeutics, 2 Dept. of Animal Biology and CNR Center<br />
for Histochemistry, 1 Dept. Histochemistry and Cytometry, IGM-CNR, Univ. of Pavia, 3<br />
Dept. General Surgery I, Univ. of Padova<br />
123.<br />
124.<br />
125.<br />
126.<br />
DAPHNIA MAGNA AS A NEW APPROACH IN THE DETECTION OF<br />
BOTULINAL TOXINS<br />
Evandri MG 1 , Bolle P 1 , Aureli P 2 , Anniballi B 2 , Mart<strong>in</strong>oli L 1 , Fenicia L 2<br />
1 Department of Pharmacology of Natural Substances and General Physiology,<br />
University “La Sapienza”, Rome, Italy; 2 National Reference Center for Botulism,<br />
National Institute of Health, Rome, Italy<br />
EFFECTS OF ACUTE AND REPEATED ETHANOL ADMINISTRATION DURING<br />
THE RAT'S BRAIN GROWTH SPURT ON BCL-2, BAX AND CASPASE-3<br />
EXPRESSION<br />
S. Carloni, E. Mazzoni, M. Cim<strong>in</strong>o, W. Baldu<strong>in</strong>i<br />
Istituto <strong>di</strong> Farmacologia e Farmacognosia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urb<strong>in</strong>o, Via S.<br />
Chiara 27, Urb<strong>in</strong>o<br />
ESCHERICHIA COLI CYTOTOXIC NECROTIZING FACTOR 1 (CNF1) IMPAIRS<br />
MUSCLE CELL DIFFERENTIATION IN C2C12 CELLS<br />
Travaglione S. 1 , Mess<strong>in</strong>a, G. 2 , Fabbri, A. 1 , Falzano, L. 1 , Giammarioli, A. 1 , Grossi,<br />
M. 2 , Ruf<strong>in</strong>i, S. 3 , Malorni W. 1 , Fiorent<strong>in</strong>i C. 1<br />
1 Ultrastructures Laboratory, Istituto Superiore <strong>di</strong> Sanità, Rome-Italy; 2 Department of<br />
Cellular and Developmental Biology, University of Rome “La Sapienza”, Rome-Italy; 3<br />
Department of Biology, University of Rome “Tor Vergata”, Rome-Italy<br />
GMP HOLISTIC QUALIFICATION OF A THERMOCYCLER USED IN THE<br />
QUALITY CONTROL OF CELL SUBSTRATES FOR PRODUCING<br />
BIOPHARMACEUTICALS AND CRUDE BULK HARVESTS FROM<br />
BIOREACTORS<br />
Barone D., Lasala R., Lombard<strong>in</strong>i E., Toso E.<br />
LCG-RBM SpA, Via Ribes, 1, 10010 – Colleretto Giacosa (TO) – Italy<br />
50<br />
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141<br />
53<br />
25<br />
138<br />
8
Poster<br />
n°<br />
127.<br />
128.<br />
129.<br />
130.<br />
131.<br />
132.<br />
133.<br />
134.<br />
135.<br />
IN VIVO ALLYLAMINE TOXICITY. INVOLVMENT OF HYDROXYL<br />
RADICALS GENERATION<br />
Pisoni I, Dragoni S., Sgaragli GP, Valoti M<br />
Dipartimento <strong>di</strong> Scienze Anatomiche e Biome<strong>di</strong>che, Univeristà <strong>di</strong> Siena, Italy<br />
INVOLVEMENT OF BRAIN DOPAMINE AND KININS ON THE DIFFERENT<br />
PRESSOR EFFECT TO CADMIUM INTRACEREBROVENTRICULAR IN LOW<br />
URINARY KALLIKREIN RATS<br />
1 Varoni MV., 1 Palomba D., °Satta M., 1 Gianorso S., 1 Anania V.<br />
1 D.B.A.- Division of Pharmacology, Faculty of Veter<strong>in</strong>ary Me<strong>di</strong>c<strong>in</strong>e and °Dpt of<br />
Pharmacognosy, Faculty of Pharmacy, University of Sassari<br />
LONG-LASTING EFFECTS OF DIETHYLSTILBESTROL ON MOUSE<br />
SPERMATOGENESIS AND SPERM CHROMATIN INDUCED BY IN UTERO<br />
EXPOSURE<br />
Tra<strong>in</strong>a M.E. 1 ., Cordelli E. 2 ., Eleuteri P. 2 , Guar<strong>in</strong>o M 1 ., Leter G. 2 , Urbani E. 1 ,<br />
Spanò M. 2<br />
1 Lab. Environmental Hygiene. Istituto Superiore <strong>di</strong> Sanità- Viale Reg<strong>in</strong>a Elena 299.<br />
00161- Rome Italy. 2 Section of Toxicology & Biome<strong>di</strong>cal Sciences, BIOTEC-MED,<br />
ENEA Casaccia, 00060-Rome Italy<br />
METAL RELEASE FROM ORTHODONTIC APPLIANCE AND DNA DAMAGE IN<br />
ORAL MUCOSA CELLS<br />
Franceschetti P 1 , Fracasso M E 1 , Doria D 1 , Orsol<strong>in</strong>i E 2 , Faccioni F 2<br />
1 Department of Me<strong>di</strong>c<strong>in</strong>e and Public Health, Section of Pharmacology, Faculty of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Verona; 2 Department of Biome<strong>di</strong>cal Morphological Sciences,<br />
Section of Dentistry, Faculty of Me<strong>di</strong>c<strong>in</strong>e, University of Verona<br />
MITOCHONDRIAL MN-SOD PLAYS A CRITICAL ROLE IN THE<br />
NEUROPROTECTIVE EFFECTS EXERTED BY ANOXIC PRECONDITIONING IN<br />
CORTICAL NEURONS EXPOSED TO OGD AND OGD/REOXYGENATION<br />
Scorziello A., Sirabella R., D’ Alessio A., Santillo M.R., Secondo A., Canzoniero<br />
L.M.T., Di Renzo G.F., Annunziato L.<br />
Division of Pharmacology, Department of Neuroscience, University of Naples<br />
“Federico II”, Via S. Pans<strong>in</strong>i 5, 80131 Naples, Italy<br />
OXIDATIVE STRESS IN RETINAL INFLAMMATION<br />
Pann<strong>in</strong>i S., Leone R.L., Cas<strong>in</strong>i P., Giorgi G.<br />
Dipartimento <strong>di</strong> Farmacologia “G. Segre”, <strong>Università</strong> <strong>di</strong> Siena<br />
POLYHALOGENATED COMPOUNDS OF APPROPRIATE CONFIGURATION<br />
INTERACT WITH MAMMALIAN OR BACTERIAL CYP ENZYMES TO<br />
INCREASE BILIRUBIN AND UROPORPHYRINOGEN OXIDATION IN VITRO<br />
Pons N., Muccioli G., De Matteis F.<br />
Departments of Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, University of Tur<strong>in</strong>,<br />
Italy<br />
POSSIBILITY TO INCREASE GLUTATHIONE LEVELS IN RAT BRAIN<br />
Cerretani D., Signor<strong>in</strong>i A., Giorgi G.<br />
Dipartimento <strong>di</strong> Farmacologia “G. Segre”. <strong>Università</strong> <strong>di</strong> Siena<br />
RETINAL OXIDATIVE STRESS IN DIABETIC RATS<br />
Signor<strong>in</strong>i A.M., Pann<strong>in</strong>i S., Runci F.M., Giorgi G.<br />
Dipartimento <strong>di</strong> Farmacologia “G. Segre”. <strong>Università</strong> <strong>di</strong> Siena<br />
51<br />
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110<br />
143<br />
138<br />
59<br />
128<br />
103<br />
112<br />
31<br />
130
Poster<br />
n°<br />
136.<br />
137.<br />
TAME-RELATED EFFECTS ON RAT FIBROBLASTS<br />
Iavicoli I., Carelli G.<br />
Institute of Occupational Health, <strong>Università</strong> Cattolica del Sacro Cuore, Largo Francesco<br />
Vito 1 – 00168 Rome<br />
THE NEURONAL REPRESSOR NRSF/REST INHIBITS APOPTOSIS IN NON-<br />
NEURONAL HUMAN CELLS<br />
Calienni M., Spamp<strong>in</strong>ato S.<br />
Department of Pharmacology, University of Bologna, Irnerio 48, 40126 Bologna, Italy<br />
52<br />
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75<br />
20
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 3A<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia car<strong>di</strong>ovascolare<br />
POSTER 138-162<br />
Moderatori: E. Cerbai (Firenze) – F. Fusi (Siena)<br />
Poster<br />
n°<br />
138.<br />
139.<br />
140.<br />
141.<br />
142.<br />
143.<br />
ACE INHIBITOR ZOFENOPRIL AMELIORATES VASCULAR REACTIVITY IN<br />
NON OBESE DIABETIC (nod) MICE<br />
Brancaleone V., Bucci M., Roviezzo F. 1 , Saggese M., Parente L. 1 Copp<strong>in</strong>i A 2 ,<br />
Evangelista S 3 , Cir<strong>in</strong>o G.<br />
Depts. of Experimental Pharmacology, Faculty of Pharmacy, University of Naples -<br />
Federico II-; 1 Pharmaceutical Science, Faculty of Pharmacy, University of Salerno,<br />
Fisciano (SA); 2 Guidotti Laboratories, La Vettola, Pisa; 3 Menar<strong>in</strong>i Research, Firenze<br />
ANGINA PECTORIS IN OUT-PATIENTS OBSERVED BY CARDIOLOGY<br />
SERVICES IN ITALY: CHARACTERISTICS AND THERAPEUTIC<br />
IMPLICATIONS<br />
Arcoraci V., Cutroneo P., Benvenuti C., Gruppo Car<strong>di</strong>oWeb, Caputi A.P.<br />
ANTIHYPERTENSIVE EFFECTS OF MANIDIPINE/DELAPRIL COMBINATION<br />
F. Pastore, M. Riunno, R. Razzetti, S. Bongrani<br />
Chiesi Farmaceutici. Parma (Italy)<br />
ANTIANGIOGENIC EFFECT OF SYNTHETIC HUMAN ENDOSTATIN-DERIVED<br />
PEPTIDES<br />
Pola S., Cattaneo MG, Francescato P ^, Vicent<strong>in</strong>i L.M.<br />
Dept of Pharmacology, Via Vanvitelli, 32 – 20129 Milano and ^Dept. of Organic and<br />
Industrial Chemistry, Via Venezian, 21 – 20133 Milano<br />
BENEFICIAL EFFECTS OF 5-AMINOISOQUINOLINONE, A NOVEL, POTENT,<br />
WATER-SOLUBLE, INHIBITOR OF POLY (ADP-RIBOSE) POLYMERASE, IN A<br />
RAT MODEL OF SPLANCHNIC ARTERY OCCLUSION AND REPERFUSION<br />
Rosanna DiPaola, Tiziana Genovese, Ivana Serra<strong>in</strong>o, Laura Dugo, Angela De Sarro,<br />
Achille P. Caputi, Salvatore Cuzzocrea<br />
BINDING AND FUNCTIONAL PARAMETERS OF A2A ADENOSINE RECEPTORS<br />
IN ESSENTIAL HYPERTENSIVE PATIENTS BEFORE AND AFTER<br />
PHARMACOLOGICAL TREATMENT<br />
Pancal<strong>di</strong> C. 1 , Varani K. 1 , Gessi S. 1 , Merighi S. 1 , Iannotta V. 1 , Cattabriga E. 1 ,<br />
Avitabile A. 1 , Manfred<strong>in</strong>i R. 2 , Portaluppi F. 2 , Borea P.A. 1<br />
1 Department of Cl<strong>in</strong>ical and Ex perimental Me<strong>di</strong>c<strong>in</strong>e, Institute of Pharmacology and 2<br />
Hypertension Center, University of Ferrara, Italy<br />
53<br />
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111<br />
49<br />
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Poster<br />
n°<br />
144.<br />
145.<br />
146.<br />
147.<br />
148.<br />
149.<br />
CHANGES OF AUTONOMIC NERVOUS RESPONSE AND VASCULAR<br />
REACTIVITY FOLLOWING RAT HINDLIMB UNLOADING<br />
De Salvatore G., 1 Desaphy J.-F., 1 Conte Camer<strong>in</strong>o D., Mitolo-Chieppa D.<br />
Department of Pharmacology and Human Physiology, School of Me<strong>di</strong>c<strong>in</strong>e and<br />
1 Department of Pharmaco-Biology, School of Pharmacy, University of Bari, Italy<br />
CHANGES OF PERIPHERAL A2A ADENOSINE RECEPTORS IN CHRONIC<br />
HEART FAILURE: A BIOCHEMICAL STUDY BEFORE AND AFTER HEART<br />
TRANSPLANTATION<br />
Varani K. 1 , Laghi-Pas<strong>in</strong>i F. 2 , Camurri A. 3 , Cattabriga E. 1 , Pancal<strong>di</strong> C. 1 , Capecchi<br />
P.L. 2 , Maccher<strong>in</strong>i M. 4 , Borea P.A. 1 , Abbracchio M.P. 3<br />
1 Dept. of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Inst. of Pharmacology, University of<br />
Ferrara, Italy; 2 Dept. of Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Immunology Sciences, Cl<strong>in</strong>ical<br />
Immunology Division and 3 Dept. of Surgery and Bioeng<strong>in</strong>eer<strong>in</strong>g, Section of Thoracic<br />
and Car<strong>di</strong>ovascular Surgery, University of Siena, Italy; 4 Dept. of Pharmacological<br />
Sciences, University of Milano, Italy<br />
DIFFERENTIAL CHANGES OF P2 RECEPTORS IN PATIENTS WITH CHRONIC<br />
HEART FAILURE UNDERGOING CARDIAC TRANSPLANTATION<br />
Banfi C. 1 2 , Ferrario S. 1 2 , De V<strong>in</strong>centi O. 1 , Fumagalli M. 1 , D’Ambrosi N. 3 ,<br />
Volonté C. 3 , Vitali E. 4 , Biglioli P. 5 , Mussoni L. 1 , Tremoli E. 1,2 , Abbracchio M.P. 1,2<br />
1 Dipartimento <strong>di</strong> Scienze Farmacologiche and 5 Centro Car<strong>di</strong>ologico Monz<strong>in</strong>o IRCCS-<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano-MILANO; 3 Fondazione Santa Lucia-ROMA; 4<br />
Ospedale “Niguarda Cà Granda”-MILANO 2 These authors equally contributed to this<br />
work<br />
EFFECT OF MANIDIPINE ON GENE EXPRESSION OF OXIDATIVE STRESS<br />
RELATED PROTEINS: p22 phox AND HO-1<br />
1 Zaghetto F, Pagn<strong>in</strong> E, Semplic<strong>in</strong>i A, Calò LA, Pess<strong>in</strong>a AC.<br />
1 Departments of Pharmacology and Anaesthesiology and Cl<strong>in</strong>ical and Experimental<br />
Me<strong>di</strong>c<strong>in</strong>e University of Padua, Italy<br />
EVALUATION OF OXIDATIVE STRESS DURING CORONARY ARTERY<br />
BYPASS GRAFTING<br />
A. Sola, A. Caiani, E. Tremoli, V. Cavalca, F. Veglia, M. De Franceschi, E. Sisillo, L.<br />
Salvi, M. Alimento, L. Boccotti, G. Folco, A. Sala<br />
Center for Car<strong>di</strong>pulmonary Pharmacology, Dept of Pharmacological Sciences,<br />
University of Milan, Centro Car<strong>di</strong>ologico Monz<strong>in</strong>o and Institute of Car<strong>di</strong>ology,<br />
University of Milan, Italy<br />
IDENTIFICATION OF THE MECHANISM BY WHICH MELANOCORTINS<br />
REVERSE HEMORRHAGIC SHOCK: BRAIN ACTIVATION OF A CHOLINERGIC<br />
ANTI-INFLAMMATORY PATHWAY<br />
Guar<strong>in</strong>i S 1 , Squadrito F 2 , Ca<strong>in</strong>azzo M.M. 1 , Giuliani D 1 , Mioni C 1 , Altavilla D 2 ,<br />
Bigiani A 3 , Ghiaroni V § , Passaniti M 1 , Leone S 1 , Bazzani C 1 , Bertol<strong>in</strong>i A 1<br />
Dept. Biome<strong>di</strong>cal Sciences, Sections of 1 Pharmacology and 3 Physiology, University of<br />
Modena and Reggio Emilia, Modena; 2 Dept. Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and<br />
Pharmacology, Section of Pharmacology, University of Mess<strong>in</strong>a, Mess<strong>in</strong>a, ITALY<br />
54<br />
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45<br />
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56<br />
146<br />
131<br />
72
Poster<br />
n°<br />
150.<br />
151.<br />
152.<br />
153.<br />
154.<br />
155.<br />
IMPAIREMENT OF ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR<br />
(EDHF) IN GLUCOCORTICOIDS INDUCED HYPERTENSION IN RAT<br />
D’ Emmanuele <strong>di</strong> Villa Bianca R. 1 , Sorrent<strong>in</strong>o R 1 , Lippolis L. 2 , Marzocco S. 2 ,<br />
Autore G. 2 , P<strong>in</strong>to A. 2<br />
1 2<br />
Department of Experimental Pharmacology, University of Naples; Department of<br />
Pharmaceutical Sciences, University of Salerno<br />
LACK OF NO REGULATION ON ANGIOTENSIN-INDUCED CALCIUM<br />
TRANSIENT IN AORTIC SMOOTH MUSCLE CELLS OF SPONTANEOUSLY<br />
HYPERTENSIVE RATS HR<br />
Failli P., Mazzetti L., Franchi-Micheli S., Cantore M., Aiello D., Ciuffi M.<br />
Department of Pharmacology University of Florence, Viale Pieracc<strong>in</strong>i 6, Florence,<br />
(Italy)<br />
MC3 RECEPTORS, BUT NOT THE C-TERMINAL Arg-Phe SEQUENCE, ARE<br />
INVOLVED IN THE PROTECTIVE EFFECT OF MELANOCORTINS AGAINST<br />
MYOCARDIAL REPERFUSION INJURY<br />
Mioni C. 1 , Giuliani D. 1 , Ca<strong>in</strong>azzo M.M. 1 , Leone S. 1 , Bazzani C. 1 , Grieco P. 2 ,<br />
Novell<strong>in</strong>o E. § , Bertol<strong>in</strong>i A. 1 , Guar<strong>in</strong>i S 1 .<br />
1 Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, University of Modena<br />
and Reggio Emilia, Modena; 2 Department of Pharmaceutical Chemistry and<br />
Toxicology, University of Napoli “Federico II”, Napoli; Italy<br />
NDP-MSH REDUCES INFLAMMATORY CELL INFILTRATION AND INFARCT<br />
SIZE IN A RAT MODEL OF PERMANENT MYOCARDIAL ISCHEMIA<br />
Leone S. 1 , Mioni C. 1 , Giuliani D. 1 , Ca<strong>in</strong>azzo M.M. 1 , Bazzani C. 1 , Zaffe D. 2 ,<br />
Botticelli A.R. 3 , Bertol<strong>in</strong>i A. 1 , Guar<strong>in</strong>i S. 1<br />
1 Dept. Biome<strong>di</strong>cal Sciences, Sect. Pharmacology and 2 Dept. Morphological Sciences<br />
and Forensic Me<strong>di</strong>c<strong>in</strong>e, University of Modena and Reggio Emilia, Modena; 3 Dept.<br />
Human Pathology, University of Pavia, Pavia; Italy<br />
PROTECTIVE EFFECTS OF M40401, A SELECTIVE SUPEROXIDE DISMUTASE<br />
MIMETIC, ON THE MULTIPLE ORGAN FAILURE INDUCED BY ZYMOSAN IN<br />
THE RAT<br />
Salvatore Cuzzocrea, Emanuela Mazzon, Rosanna DiPaola, Tiziana Genovese, Ivana<br />
Serra<strong>in</strong>o, Laura Dugo, Achille P. Caputi, Daniela Salvem<strong>in</strong>i<br />
REPERTAXIN (DF 1681Y), A NOVEL, POTENT AND SPECIFIC NON-PEPTIDIC<br />
SMALL MOLECOLE INHIBITOR OF CXCL8, AS A CANDIDATE DRUG IN<br />
POST-ISCHEMIA REPERFUSION INJURY.<br />
Mosca M. 1 , Bizzarri C. 2 , Allegretti M. 2 , Di Cioccio V. 2 , Benigni A. 4 , Cutrín J.C. 6 ,<br />
Cavalieri B. 5 , Poli G. 5 , Novell<strong>in</strong>i R. 3 , Bert<strong>in</strong>i R. 2 , Mantovani A. 5 , Colotta F. 2<br />
1 Consorzio BIOLAQ, 67100 L’Aquila; 2 Dompé SpA, 67100 L’Aquila; 3 Dompé SpA<br />
20122 Milan, Italy; 4 Laboratori M. Negri 24100 Bergamo, Italy; 5 Laboratori M. Negri<br />
24100 Milan, Italy; 6 Dep. Scienze Cl<strong>in</strong>iche e Biologiche, Univ. <strong>di</strong> Tor<strong>in</strong>o, 10043<br />
Orbassano (TO), Italy<br />
55<br />
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44<br />
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77<br />
39<br />
97
Poster<br />
n°<br />
156.<br />
157.<br />
158.<br />
159.<br />
160.<br />
161.<br />
162.<br />
RESPONSIVENESS OF ALVEOLAR MACROPHAGES FROM SMOKERS, NON-<br />
SMOKERS AND PATIENTS WITH LUNG DISEASES TO TACHYKININS AND<br />
MACROPHAGE STIMULATING PROTEIN (MSP)<br />
Bardelli C., Balbo P 1 , Gunella G., Sp<strong>in</strong>a S., Viano I., Brunelleschi S.<br />
Dept. Me<strong>di</strong>cal Sciences, University of Piemonte Orientale “A. Avogadro”, Via Solaroli,<br />
17 – 28100 Novara; 1 Az. Ospedaliera “Maggiore della Carità”, Novara<br />
THE ACH-INDUCED CONTRACTION IN THE AORTA OF SPONTANEOUSLY<br />
HYPERTENSIVE RATS<br />
Mazzetti L., Franchi-Micheli S., Ciuffi M., Cantore M., Giacalone M., Zilletti L., Failli<br />
P.<br />
Department of Pharmacology University of Florence, Viale Pieracc<strong>in</strong>i 6, Florence,<br />
(Italy)<br />
THE COMBINATION OF SR141716A AND ACTH-(1-24) IMPROVES THE<br />
THERAPEUTIC EFFICACY IN THE MANAGEMENT OF HEMORRHAGIC<br />
SHOCK<br />
Bazzani C., Ca<strong>in</strong>azzo M.M., Mioni C., Giuliani D., Leone S., Bertol<strong>in</strong>i A., Guar<strong>in</strong>i S.<br />
Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, University of Modena<br />
and Reggio Emilia, Modena; Italy<br />
THE EFFECT OF OMEGA-3 POLYUNSATURATED FATTY ACIDS (v-3PUFA)<br />
ON THE ASYMMETRYC DIMETHYL ARGININE (ADMA) PLASMA<br />
CONCENTRATIONS IN AGED SPONTANEOUSLY HYPERTENSIVE RATS<br />
(SHR).<br />
L. Raimon<strong>di</strong>, L. Sartiani, P. De Paoli, M. Lodovici, F. Guglielmi, 1 F. Visioli, L.<br />
Cioni, R. Piris<strong>in</strong>o, G. Banchelli, E. Cerbai, A. Mugelli.<br />
Dept. of Pharmacology, University of Florence. 1 Dept. of Pharmacology, University of<br />
Milan<br />
THE REDOX STATE OF PLASMA THIOLS IN HEALTHY SUBJECTS OF<br />
DIFFERENT AGE<br />
Di Giuseppe D., Frosali S., Di Simplicio P.<br />
Neuroscience Department, Pharmacology Unit, University of Siena, Siena, Italy<br />
UT RECEPTORS MEDIATED UROTENSIN-II INDUCED PLASMA<br />
EXTRAVASATION: AN IN VIVO STUDY IN MICE<br />
Rizzi A, Vergura R, Camarda V, Calò G, 1 Guerr<strong>in</strong>i R, 1 Salvatori S, Regoli D.<br />
Dept of Pharmacology and 1 Dept. of Pharmaceutical Sciences, University of Ferrara,<br />
44100 Ferrara Italy<br />
WARFARIN VS ANTIPLATELET AGENTS IN NONVALVULAR ATRIAL<br />
FIBRILLATION AMONG VERY ELDERLY PATIENTS<br />
Gambassi G, Lapane KL, Pedone C, Liperoti R, Bernabei R.<br />
Centro <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a dell’Invecchiamento, <strong>Università</strong> Cattolica del Sacro Cuore, Rome,<br />
Italy; Center for Gerontology and Health Care Research, Brown University, Providence,<br />
RI, USA<br />
56<br />
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49<br />
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64
VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 3A<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia car<strong>di</strong>ovascolare<br />
POSTER 163-189<br />
Moderatori: L. Beani (Ferrara) - B. Fabris (Trieste)<br />
Poster<br />
n°<br />
163.<br />
164.<br />
165.<br />
166.<br />
167.<br />
168.<br />
A NOVEL ENDOTHELIUM-INDEPENDENT VASORELAXANT MECHANISM<br />
INDUCED BY ELECTRIC FIELD STIMULATION IN RABBIT FEMORAL<br />
ARTERY<br />
Fabi F., Spallotta C., Del Basso P.<br />
Laboratory of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Roma<br />
ACTIVITY OF CLENBUTEROL ON b57- AND b2- CARDIAC ADRENOCEPTORS<br />
G. Mazzanti, C. Daniele, L. Batt<strong>in</strong>elli, G. Brambilla 1 , A. Loizzo 1<br />
Department of Pharmacology of Natural Substances and General Physiology,<br />
University “La Sapienza” 1 Istituto Superiore <strong>di</strong> Sanità - Rome, Italy<br />
AKT ACTIVATION IS INVOLVED IN THE VASOCONSTRICTION ACTIVITY OF<br />
VEGF IN INJURED RAT AORTA<br />
Filippi S., Parenti A., Bellik L., Ledda F.<br />
Department of Precl<strong>in</strong>ical Cl<strong>in</strong>ical and Pharmacology, University of Florence, Florence<br />
(Italy)<br />
ANTIOXIDANT EFFECT OF L-CARNITINE AND ITS SHORT CHAIN ESTERS. A<br />
MOLECULAR BIOLOGY APPROACH<br />
Pagn<strong>in</strong> E, Rizzato S, 1 Zaghetto F, Semplic<strong>in</strong>i A, Calò LA, Pess<strong>in</strong>a AC.<br />
Departments of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and 1 Pharmacology and<br />
Anaesthesiology, University of Padua, Italy<br />
APRIKALIM ABOLISCE IL PROLUNGAMENTO DELL’INTERVALLO QT<br />
PROVOCATO DALLA TIORIDAZINA TRAMITE L’ATTIVAZIONE DEI CANALI<br />
KATP SARCOPLASMATICI.<br />
L. Testai, V. Calderone, A. Salvadori, P. Nieri, E. Mart<strong>in</strong>otti.<br />
Dipartimento <strong>di</strong> Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, <strong>Università</strong> <strong>di</strong><br />
Pisa<br />
ATTENUATION OF MYOCARDIAL STUNNING AND IMPROVEMENT OF<br />
SYSTO-DIASTOLIC CONTRACTILITY BY PST2744 IN ACUTE ISCHEMIC /<br />
REPERFUSED MYOCARDIUM.<br />
Mattera G.G., Loi F. M.P. , Botarelli M., Boccuti S, Mart<strong>in</strong>ez V., Alivern<strong>in</strong>i M.L.,<br />
Pacifici L., Carm<strong>in</strong>ati P.<br />
General Pharmacology Dept, R&D Sigma Tau SpA, Pomezia Italy<br />
57<br />
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53<br />
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58<br />
101<br />
137<br />
88
Poster<br />
n°<br />
169.<br />
170.<br />
171.<br />
172.<br />
173.<br />
174.<br />
175.<br />
176.<br />
CHARACTERIZATION OF CA 2+ ENTRY CHANNELS IN NORADRENALINE-<br />
AND U 46619-INDUCED CONTRACTIONS OF RABBIT SAPHENOUS VEINS<br />
Perrotta D., Stati T., Fabi F., Del Basso P.<br />
Laboratory of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Roma<br />
CHRONIC EXPOSURE TO ENDOTHELIN-1 ALTERS<br />
ELECTROPHYSIOLOGICAL PROPERTIES OF CARDIAC HL-1 CELLS<br />
Laura Sartiani, Francesca Stillitano, Raffaele Paola, Alessandro Mugelli, Elisabetta<br />
Cerbai<br />
Dipartimento <strong>di</strong> Farmacologia Precl<strong>in</strong>ica e Cl<strong>in</strong>ica, Viale Pieracc<strong>in</strong>i 6, 50139 Firenze<br />
MOLECULAR EXPRESSION OF THE HYPERPOLARIZATION-ACTIVATED<br />
CHANNEL IN THE HUMAN VENTRICLE: RELATIONSHIP WITH FUNCTIONAL<br />
PROPERTIES<br />
Paola R., Stillitano F., DePaoli P., Sartiani L., Mugelli A., Cerbai E.<br />
Department of Pharmacology, University of Florence, Florence, Italy<br />
DIFFERENCES IN THE PHARMACOLOGICAL PROFILE OF NITROASPIRIN<br />
DERIVATIVES ARE CRITICAL TO UNDERSTAND THE STRUCTURAL<br />
FEATURES REQUIRED FOR PROPER NITRIC OXIDE-RELEASING<br />
PROPERTIES.<br />
Presotto C., Maucci C., Ciliberti N., Monopoli A., Ong<strong>in</strong>i E., Impagnatiello F.<br />
Nicox Research Institute, Bresso, Milan<br />
ELECTRICAL STIMULATION OF EFFERENT VAGAL FIBRES PREVENTS IN<br />
REAL-TIME NUCLEAR FACTOR-kB AND INFLAMMATORY CASCADE<br />
ACTIVATION, AND PROLONGS SURVIVAL, IN HEMORRHAGIC SHOCK<br />
Ca<strong>in</strong>azzo M.M. 1 , Altavilla D. 2 , Giuliani D. 1 , Mioni C. 1 , Leone S. 1 , Bazzani C. 1 ,<br />
Mar<strong>in</strong>i H. 2 , Bigiani A. 3 , Bertol<strong>in</strong>i A. 1 , Squadrito F. 2 , Guar<strong>in</strong>i S. 1<br />
Department of Biome<strong>di</strong>cal Sciences, Sections of 1 Pharmacology and 3 Physiology,<br />
University of Modena and Reggio Emilia, Modena; 2 Department of Cl<strong>in</strong>ical and<br />
Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology, Section of Pharmacology, University of<br />
Mess<strong>in</strong>a, Mess<strong>in</strong>a; Italy<br />
ENDOGENOUS VEGF-A IS RESPONSIBLE FOR THE MITOGENIC EFFECT OF<br />
MONOCYTE CHEMOATTRACTANT PROTEIN-1 ON VASCULAR SMOOTH<br />
MUSCLE CELLS<br />
Parenti A, Bellik L, Filippi S, Ledda F<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, University of Florence, Italy<br />
ENDOTHELIUM-DERIVED NO AND EDHF LIMITS SYMPATHETIC<br />
CONTRACTION IN RABBIT MESENTERIC ARTERY<br />
Spallotta C., Del Basso P., Maccari S. & Fabi F.<br />
Laboratory of Pharmacology, Istituto Superiore <strong>di</strong> Sanita’, Roma.<br />
ERK1-2 AND P38 MAPK REGULATE MMP/TIMP BALANCE AND FUNCTION<br />
ELICITED BY THROMBOSPONDIN-1 FRAGMENTS ON MICROVASCULAR<br />
ENDOTHELIUM<br />
Donn<strong>in</strong>i S., Morbidelli L., Santoro A., 1 Taraboletti G., Ziche M.<br />
Pharmacology Section, Dept. Molecular Biology, University of Siena, Siena, Italy and 1<br />
Department of Oncology, Mario Negri Institute for Pharmacological Research (G.T.),<br />
Bergamo, Italy<br />
58<br />
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107<br />
126<br />
104<br />
114<br />
19<br />
104<br />
131<br />
51
Poster<br />
n°<br />
177.<br />
178.<br />
179.<br />
180.<br />
181.<br />
182.<br />
183.<br />
184.<br />
185.<br />
GENERATION OF ENDOTHELIAL CELLS FROM HUMAN PROGENITOR<br />
CELLS<br />
Bellik L, Parenti A, Filippi S, Ledda F<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, University of Florence, Italy<br />
INHIBITORY EFFECTS OF CISTUS INCANUS L. AND CISTUS<br />
MONSPELIENSIS L. ON CONTRACTILE RESPONSES IN ISOLATED<br />
INTESTINAL AND AORTIC SMOOTH MUSCLE OF RAT<br />
1 Attaguile G., 2 Perticone G., 2 Mania G., 3 Savoca F., 2 PennisiG., 1 Salomone S.<br />
1 Department of Experimental and Cl<strong>in</strong>ical Pharmacology, 2 Department of Chemical<br />
Sciences, 3 Department of Botany, University of Catania<br />
INOTROPIC EFFECT “IN VITRO” OF AMPHETAMINE AND ITS DERIVATES<br />
MDMA AND MDA<br />
Anton<strong>in</strong>i Antonella, Peluso Ilaria, Palmery Maura.<br />
<strong>Università</strong> <strong>di</strong> Roma “la Sapienza” Dipartimento <strong>di</strong> Farmacologia delle Sostanze<br />
Naturali e Fisiologia Generale<br />
LEUKOTRIENE C4, D4 AND E4 NEGATIVE INOTROPIC EFFECT IN RABBIT<br />
CARDIAC MYOCYTES: EVIDENCES FOR CYS-LT2 INVOLVEMENT<br />
S. Viappiani, R. Macianskiene, A. Sala, G. Folco, K. Mubagwa<br />
Insitute of Pharmacological Sciences, Univ. of Milan, ITALY and Department of Exp.<br />
Surgery, Catholic Univ. of Leuven, BELGIUM<br />
LIPID PEROXIDATION INHIBITION REDUCES NUCLEAR FACTOR-kB (NF-kB)<br />
ACTIVATION AND NEOINTIMAL HYPERPLASIA INDUCED BY FLOW<br />
INTERRUPTION OF THE CAROTID ARTERY<br />
Bitto A, Mar<strong>in</strong>i H, Sem<strong>in</strong>ara P, Esposito M, Altavilla D, Caputi AP, Squadrito F.<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy<br />
MECHANISMS OF THAPSIGARGIN-INDUCED ENDOTHELIUM -DEPENDENT<br />
RELAXATION IN RABBIT SAPHENOUS VEINS<br />
Maccari S., Fabi F., Del Basso P.<br />
Laboratory of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Roma<br />
MODULATION OF VASCULAR TONE BY PROPIONYL-L-CARNITINE: DIRECT<br />
EFFECTS AND ENDOTHELIUM-MEDIATED EFFECTS<br />
Salomone S., Chisari M., Amico-Roxas M.<br />
Department of Experimental and Cl<strong>in</strong>ical Pharmacology, University of Catania<br />
MOLECULAR AND HISTOLOGICAL ASPECTS OF THE NEGATIVE<br />
REMODELING PROCESS INDUCED BY SURGICAL INJURY OF RAT CAROTID<br />
B. R<strong>in</strong>al<strong>di</strong>, A. Forte, N. Carusio, W. Filippelli, A. Casc<strong>in</strong>o, F. Rossi * , A. Filippelli *<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology “L.Donatelli”,<br />
Research Center of Car<strong>di</strong>ovascular Diseases; Faculty of Me<strong>di</strong>c<strong>in</strong>e and Surgery, Second<br />
University of Naples<br />
NEW OLIVE OIL ISOCHROMAN PREVENTS THE INTERACTION OF<br />
SUPEROXIDE AND NITRIC OXIDE<br />
Orlando R., Franconi M., Togna A.R., Marra C. 1 , Togna G.I.<br />
Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, 1 Dipartimento <strong>di</strong> Chimica;<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Roma “La Sapienza”<br />
59<br />
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149<br />
4<br />
3<br />
144<br />
13<br />
80<br />
124<br />
118<br />
100
Poster<br />
n°<br />
186.<br />
187.<br />
NITRIC OXIDE MEDIATES VASCULAR ENDOTHELIAL GROWTH FACTOR<br />
GENE TRANSFER EFFECTS ON WOUND HEALING AFTER EXPERIMENTAL<br />
BURN INJURY<br />
Squadrito F , Deodato B, Altavilla D, Mar<strong>in</strong>i H, Giacca M 1 , Caputi AP<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy. 1 Molecular Me<strong>di</strong>c<strong>in</strong>e Laboratory, International Centre for Genetic<br />
Eng<strong>in</strong>eer<strong>in</strong>g and Biotechnology (ICGEB), Trieste, Italy<br />
NO/CGMP PATHWAY LIES DOWNSTREAM TO MATRIX METALLO-<br />
PROTEINASE ACTIVATION IN CORONARY ANGIOGENESIS<br />
Donn<strong>in</strong>i S., Morbidelli L., Lus<strong>in</strong>i L., 1 Schulz R., Ziche M.<br />
Pharmacology Section, Dept. Molecular Biology, University of Siena, Siena, Italy and<br />
1 Dept. Pe<strong>di</strong>atrics and Pharmacology, Car<strong>di</strong>ovascular Research Group, University of<br />
Alberta, Edmonton, Alberta, Canada<br />
188. PENTOXIFYLLINE PREVENTS SPONTANEOUS BRAIN ISCHEMIA IN<br />
STROKE-PRONE RATS<br />
Mussoni L, Banfi C, Sironi L, Lodetti B, Gelosa P, Guerr<strong>in</strong>i U, Tremoli E<br />
Department of Pharmacological Sciences, University of Milan, and Monz<strong>in</strong>o<br />
Car<strong>di</strong>ologic Center IRCCS, Milan, Italy<br />
189.<br />
PHARMACOLOGICAL SCREENING OF NOVEL ANTIPLATELET AGENTS<br />
WITH ANALGESIC ACTIVITY<br />
Tognol<strong>in</strong>i M., Chiavar<strong>in</strong>i M., Ballabeni V., Impicciatore M., 1 Bruno O., 1 Brullo C.,<br />
Barocelli E.<br />
Dip. Scienze Farmacologiche, Biologiche e Chimiche Applicate <strong>Università</strong> <strong>di</strong> Parma,<br />
Parma; 1 Dip. Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Genova<br />
60<br />
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VENERDI’ 27 GIUGNO<br />
_______________________________________________________________________AULA 3A<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia delle funzioni <strong>di</strong>gestiva, respiratoria e dell’apparato<br />
urogenitale.<br />
POSTER 190-215<br />
Moderatore: M. Marchi (Genova)<br />
Poster<br />
n°<br />
190.<br />
191.<br />
192.<br />
193.<br />
ADVERSE DRUG REACTIONS OF AZATHIOPRINE THERAPY IN PATIENTS<br />
WITH INFLAMMATORY BOWEL DISEASE AND RELATION WITH<br />
THIOPURINE-S-METHYLTRANSFERASE POLYMORPHISM<br />
Stocco G. 1 , Martelossi S. 2 , Barb<strong>in</strong>o A. 3 , Fontana M. 4 , Malusà N. 5 , Bartoli F. 1 ,<br />
Candussio L. 1 , Decorti G. 1 , Ventura A. 2 , Giral<strong>di</strong> T 1<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Trieste, 2 I.R.C.C.S. Burlo-<br />
Garofolo Trieste, 3 I.R.C.C.S. Gasl<strong>in</strong>i, Genova, 4 Hospital Buzzi, Milano, 5 Department<br />
of Prevention, A.S.S. N.1, Trieste<br />
ANTISECRETORY AND GASTROPROTECTIVE ACTIVITIES OF A NITRIC<br />
OXIDE (NO)-RELEASING DERIVATIVE OF THE PROTON PUMP INHIBITOR<br />
RABEPRAZOLE<br />
Coruzzi G., Adami M., Guaita E., Sorba G. 1 , Galli U. 1 , Gasco A. 1<br />
Dept. of Human Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, Section of<br />
Pharmacology, University of Parma, Italy; 1 Dip. <strong>di</strong> Scienza e Tecnologia del Farmaco,<br />
<strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o, Italia<br />
APOPTOSIS EVOKED BY ANTI-HuD ANTIBODY IN THE ENTERIC NERVOUS<br />
SYSTEM<br />
M Bovara, 1 E Cervio, G Barbara, 2 G Sarnelli, 3 F De Ponti, V Stanghell<strong>in</strong>i, S<br />
Guerr<strong>in</strong>i, 1 M Ton<strong>in</strong>i, 2 R Cuomo, R Cor<strong>in</strong>aldesi, R De Giorgio.<br />
Dept Int Med & Gastro, and 3 Dept Pharmacol, Univ Bologna; 1 Dept Phys & Pharm<br />
Sci, Univ Pavia; 2 Dept Cl<strong>in</strong> Exp Med & Hepatogastroent, Univ Federico II, Naples,<br />
Italy<br />
ATTENUATED CERULEIN INDUCED PANCREATITIS IN NF-kB DEFICIENT<br />
MICE<br />
Passaniti M, M<strong>in</strong>utoli L, Sem<strong>in</strong>ara P, Mar<strong>in</strong>i H, Esposito M, Altavilla D, Caputi AP,<br />
Squadrito F<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy<br />
61<br />
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133<br />
38<br />
16<br />
104
Poster<br />
n°<br />
194.<br />
195.<br />
196.<br />
197.<br />
198.<br />
199.<br />
200.<br />
CHARACTERIZATION OF ELECTRICAL FIELD STIMULATION-INDUCED<br />
CALCITONIN GENE-RELATED PEPTIDE RELEASE FROM THE RAT GASTRIC<br />
FUNDUS<br />
Currò D., De Marco T.<br />
Institute of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, Catholic University of the Sacred<br />
Heart, Rome, Italy<br />
EFFECTS OF THE PLATELET AGGREGATION INHIBITOR INDOBUFEN ON<br />
MECHANISMS OF GASTRIC MUCOSAL PROTECTION<br />
1 Baschiera F., 1 Fornai M., 2 Vassalle C., 2 Lubrano W., 3 Natale G., 4 Evangelisti L., 1<br />
Blan<strong>di</strong>zzi C., 1 Del Tacca M.<br />
1 Division of Pharmacology and Chemotherapy, Dept. of Oncology, Transplants, and<br />
Advanced Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e; 3 Dept. of Human Morphology and Applied<br />
Biology; 4 Dept. of Experimental Pathology, Me<strong>di</strong>cal Biotechnologies, Infectivology<br />
and Epidemiology, University of Pisa; 2 Institute of Cl<strong>in</strong>ical Physiology, National<br />
Research Council, Pisa, Italy<br />
FIRST-PRESSED EXTRAVIRGIN OLIVE OIL REDUCES SEROTONINE-<br />
INDUCED GASTRIC OXIDATIVE DAMAGE IN RATS<br />
Nenc<strong>in</strong>i C., Runci F.M., Barberi L., Giorgi G.<br />
Dipartimento <strong>di</strong> Farmacologia “Giorgio Segre”, <strong>Università</strong> <strong>di</strong> Siena<br />
FUNCTIONAL CHARACTERISATION OF THE NOVEL HISTAMINE H3<br />
RECEPTOR AGONIST, VUF 5810, ON THE ISOLATED GUINEA PIG ILEUM<br />
G. Coruzzi, E. Poli, A. Menozzi, C. Pozzoli, R. Kitbunnadaj 1 , H. Timmerman, R.<br />
Leurs 1<br />
Dept. of Human Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, Section of<br />
Pharmacology, University of Parma, Via Volturno 39, I-43100 Parma, and 1 Dept. of<br />
Pharmacochemistry, Free University of Amsterdam, De Boelelaan 1083, 1081 HV<br />
Amsterdam<br />
HISTAMINE H3 RECEPTORS MEDIATE ANTISECRETORY EFFECTS IN THE<br />
ISOLATED RAT STOMACH<br />
Adami M., Coruzzi G., Guaita E., Kitbunnadaj R. 1 , Timmerman H. 1 , Leurs R. 1<br />
Dept. of Human Anat., Pharmacol. and Forensic Med., Section of Pharmacol., Univ. of<br />
Parma, Italy; 1 Pharmacochemistry, Dept. of Pharmacol., Free Univ. of Amsterdam,<br />
The Netherlands<br />
INTERACTION OF BILE ACIDS WITH THE FARNESOID-INTESTINAL BILE<br />
ACID-BINDING PROTEIN SYSTEM DETECTED BY A BIOLUMINESCENT<br />
ASSAY. ROLE OF ANTAGONISTS IN CHOLESTEROL HOMEOSTASIS<br />
G. Campana 1 , P. Pas<strong>in</strong>i 2 , A. Roda 2 , S. Spamp<strong>in</strong>ato 1<br />
1 Dept. Of Pharmacology and 2 Dept. of Pharmaceutical Sciences- Univ. of Bologna -<br />
Irnerio 48 - 40126 Bologna<br />
MUCOSAL 5-AMINOSALICYLIC ACID CONCENTRATIONS IN PATIENT WITH<br />
ULCERATIVE COLITIS<br />
Palumbo G., Sponta A.M., Frieri G. 1 , Palumbo P., Primavera L.G.<br />
Cattedra <strong>di</strong> Farmacologia Me<strong>di</strong>ca, 1 Cattedra <strong>di</strong> Gastroenterologia, Dipartimento <strong>di</strong><br />
Me<strong>di</strong>c<strong>in</strong>a Interna, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> L’Aquila<br />
62<br />
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39<br />
9<br />
98<br />
38<br />
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21<br />
102
Poster<br />
n°<br />
201.<br />
202.<br />
203.<br />
204.<br />
205.<br />
206.<br />
207.<br />
PHARMACOLOGICAL EVALUATION OF THE PLATELET SEROTONIN<br />
TRANSPORTER IN PATIENTS WITH IRRITABLE BOWEL SYNDROME<br />
BEFORE AND AFTER TREATMENT WITH ALOSETRON<br />
1 Stasi C., 1 Bell<strong>in</strong>i M., 1 Rappelli L., 2 Blan<strong>di</strong>zzi C., 2 Colucci R., 1 Costa F., 1<br />
Mumolo M.G., 1 Marchi S., 3 Giannacc<strong>in</strong>i G., 2 Del Tacca M.<br />
1 Section of Gastroenterology, Department of Internal Me<strong>di</strong>c<strong>in</strong>e; 2 Division of<br />
Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced<br />
Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e; 3 Laboratory of Biochemistry, Department of Psychiatry,<br />
Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy<br />
ROLE OF TRPV1 AND SP IN ETHANOL INDUCED PLASMA EXTRAVASATION<br />
IN THE MOUSE STOMACH<br />
Gazzieri D., Trevisani M., Geppetti P 1 ., Harrison, S.<br />
Center of Excellence for the Study of Inflammation, University of Ferrara, Ferrara; 1<br />
Department of Critical Care; Me<strong>di</strong>c<strong>in</strong>e & Surgery, University of Firenze, Firenze, Italy<br />
STIMULATORY EFFECT OF PG-KII, AN NK3 TACHYKININ RECEPTOR<br />
AGONIST, ON ISOLATED PANCREATIC ACINI: SPECIES DIFFERENCES<br />
L<strong>in</strong>ari G., Andreassi A, Broccardo M, Di Sario F., DiGiulio A., Improta G.<br />
Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia "V. Erspamer" - I 1 Facoltà <strong>di</strong><br />
Me<strong>di</strong>c<strong>in</strong>a e Chirurgia - <strong>Università</strong> "La Sapienza" – Roma<br />
THE b- 3ADRENOCEPTOR AGONIST SR58611A AMELIORATES<br />
EXPERIMENTAL COLITIS IN RATS.<br />
Vas<strong>in</strong>a V, Abu-Gharbieh E, Barbara G 1 , De Giorgio R 1 , Cor<strong>in</strong>aldesi R 1 , De Ponti F.<br />
Dept. of Pharmacology & 1 Dept. of Internal Me<strong>di</strong>c<strong>in</strong>e & Gastroenterology, University<br />
of Bologna, Bologna, Italy<br />
CLENBUTEROL ANTAGONIZES GLUCOCORTICOID-INDUCED ATROPHY<br />
AND FIBER TYPE TRANSFORMATION IN MUSCLES OF MICE<br />
Boschi F. 1 , Verri M. 1 , Bott<strong>in</strong>elli R. 2 , Dossena M. 1 , Ton<strong>in</strong>i M. 1 Pastoris O. 1<br />
1 Dipartimento <strong>di</strong> Scienze Fisiologiche-Farmacologiche, Cellulari-Molecolari Sez. <strong>di</strong><br />
Farmacologia e Biotecnologie Farmacologiche, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Pavia; 2<br />
Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale Sez. <strong>di</strong> Fisiologia Umana, <strong>Università</strong> <strong>degli</strong><br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> Pavia<br />
EFFECTS OF TGF-{BETA} AND BUDESONIDE ON MAPK ACTIVATION AND<br />
APOPTOSIS IN AIRWAY EPITHELIAL CELLS<br />
Gallelli L, Pelaia G., Cuda G., Fratto D., Maselli R., De Sarro GB, Marsico S.A.<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, University “Magna Graecia” of<br />
Catanzaro<br />
EXPRESSION AND FUNCTION OF ADENOSINE RECEPTORS IN GUINEA-PIG<br />
AIRWAYS: ROLE OF ALLERGIC SENSITIZATION<br />
Ad<strong>in</strong>olfi B., Nieri P., Mart<strong>in</strong>otti E., Breschi M.C.<br />
Dipartimento <strong>di</strong> Psichiatria, Neurobiologia, Farmacologia e Biotecnologie; Facoltà <strong>di</strong><br />
Farmacia, Via Bonanno 6, 56126 PISA<br />
208. INFLUENCE OF RESTING TENSION ON PROTEASE ACTIVATED RECEPTORS-<br />
MEDIATED RELAXATION IN GUINEA-PIG TRACHEAS<br />
Cantore M., Franchi-Micheli S., Mazzetti L., Ciuffi M., Zilletti L., Failli P.<br />
Department of Pharmacology University of Florence, Viale Pieracc<strong>in</strong>i 6, Florence,<br />
(Italy)<br />
63<br />
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132<br />
66<br />
79<br />
143<br />
15<br />
63<br />
1<br />
23
Poster<br />
n°<br />
209.<br />
210.<br />
211.<br />
212.<br />
213.<br />
214.<br />
215.<br />
MUSCARINIC CONTROL OF CHOLINERGIC FUNCTION IN PORCINE<br />
AIRWAYS: PRE- AND POSTJUNCTIONAL MECHANISMS<br />
Cond<strong>in</strong>o A.M., Boselli C., 1 Gioglio L., 2 Dellabianca A., 3 Ton<strong>in</strong>i M., D’ Agost<strong>in</strong>o G.<br />
Department of Experimental and Applied Pharmacology, School of Pharmacy, 1<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, 2 Department of Occupational Me<strong>di</strong>c<strong>in</strong>e and 3<br />
Department of Physiological and Pharmacological Sciences, University of Pavia, Pavia,<br />
Italy<br />
USE OF ALTERATED PEPTIDE LIGANDS TO MODULATE<br />
BRONCHOCONSTRICTION INDUCED BY SPECIFIC BRONCHIAL<br />
CHALLENGE IN RABBITS SENSITIZED TO PARIETARIA JUDAICA<br />
DAgost<strong>in</strong>o B 1 , Marrocco G 1 , De Nardo M 1 , Gallelli L 2 , Falciani M 1 , Lampa E 1 , De<br />
Rosa G 1 , Cangianiello M 1 , Rossi F 1<br />
1 Section of Pharmacology, Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Second University<br />
of Naples, Naples, Italy 2 Chair of Pharmacology, Department of Experimental and<br />
Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, University "Magna Graecia" of Catanzaro, Italy<br />
ALPHA1 ADRENERGIC RECEPTOR SUBTYPES IN MALE AND FEMALE<br />
HUMAN URINARY BLADDER: SEX AND REGIONAL COMPARISON<br />
Peroni A., Sigala S. 1 , Mirabella G., Fornari S. 1 , Simeone C., Pezzotti G., Spano P.F. 1<br />
, Cosciani Cunico S.<br />
Division of Urology, School of Me<strong>di</strong>c<strong>in</strong>e; 1 Sect. of Pharmacology, Dept. of Biomed.<br />
Sci. and Biotec., University of Brescia, Brescia, Italy<br />
IMPAIRMENT BY ANOXIA AND GLUCOPENIA OF THE CONTRACTILE<br />
RESPONSE OF HUMAN AND MONKEY DETRUSOR STRIPS TO INTRINSIC<br />
NERVE STIMULATION AND ITS INCREASE BY 2-DEOXYGLUCOSE<br />
F. Pess<strong>in</strong>a, A. Petri, G. Matteucci 1 , GP. Sgaragli<br />
Istituto <strong>di</strong> Scienze Farmacologiche, Via A. Moro, 2, 53100 Siena, Italia; 1 Chiron<br />
Bioc<strong>in</strong>e S.p.A., Via Fiorent<strong>in</strong>a 1, 53100 Siena, Italia<br />
PROTOCTIVE EFFECT OF 1,25-DIHYDROXYVITAMIN D3 ON GLOMERULAR<br />
PODOCYTES IN EXPERIMENTAL GLOMERULONEPHRITIS<br />
Migliori M, Doublier S 1 , Filippi C, Panichi V 2 , Taccola D 2 , Origlia N, Mannari C,<br />
Camussi G 1 , Giovann<strong>in</strong>i L.<br />
Departments of Neuroscience (Pharmacology sect.), and 2 Internal Me<strong>di</strong>c<strong>in</strong>e, University<br />
of Pisa; Department of Internal Me<strong>di</strong>c<strong>in</strong>e, University of Tur<strong>in</strong>, Italy<br />
SUCRALFATE IMPROVES WOUND HEALING PROCESS IN RAT<br />
EXPERIMENTAL CERVICITIS<br />
Origlia N, Mannari C, Migliori M, Filippi C, Boldr<strong>in</strong>i E 1 , Giovann<strong>in</strong>i L<br />
Neuroscience Departement (Pharmacology sect.), University of Pisa and Farmigea<br />
s.p.a., Pisa, Italy<br />
TOCOLYTIC EFFECTS OF AS603831, A NEW ORALLY ACTIVE NON-PEPTIDE<br />
ANTAGONIST OF THE OXYTOCIN RECEPTOR<br />
Enrico Gillio Tos, 1 Rocco Cirillo, 1 Matthias Schwarz, 2 André Chollet 2<br />
1 2<br />
LCG-RBM, Exp. Pharmacology Unit, I-10010 Colleretto Giacosa (TO), Italy<br />
Serono Pharmaceutical Research Institute, CH-1228 Geneva<br />
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107<br />
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VENERDI’ 27 GIUGNO<br />
___________________________________________________________CORRIDOIO II° PIANO<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia endocr<strong>in</strong>a e del metabolismo.<br />
POSTER 216-238<br />
Moderatore: P. Sacerdote (Milano)<br />
Poster<br />
n°<br />
216.<br />
217.<br />
218.<br />
219.<br />
220.<br />
AGING-RELATED ALTERATIONS OF CALCIUM HOMEOSTASIS IN RAT<br />
SKELETAL MUSCLES ARE RESTORED BY GROWTH HORMONE<br />
ADMINISTRATION<br />
Fraysse B, Rolland J-F, Pierno S, De Luca A, Desaphy J-F, Conte Camer<strong>in</strong>o D.<br />
Sezione <strong>di</strong> Farmacologia, Dipartimento Farmacobiologico, Facoltà <strong>di</strong> Farmacia,<br />
<strong>Università</strong> <strong>degli</strong> stu<strong>di</strong> <strong>di</strong> Bari, Via Orabona, 4-campus, 70125 BARI, Italia<br />
CHRONIC TREATMENT WITH LOSARTAN PREVENTS THE<br />
ELECTROPHYSIOLOGICAL REMODELING OF THE DIABETIC RAT HEART<br />
DePaoli P, Raimon<strong>di</strong> L, Lonardo G, Piris<strong>in</strong>o R, Mugelli A, Cerbai E.<br />
Department of Pharmacology, University of Florence, Italy<br />
EFFECTS OF CALCITONIN, AMYLIN AND CALCITONIN GENE-RELATED<br />
PEPTIDE ON OSTEOPROTEGERIN SECRETION FROM HUMAN<br />
OSTEOBLASTS<br />
Ruggeri F., 1 Sibilia V., Maccar<strong>in</strong>elli G., 1 Netti C., Cocchi D.<br />
Dept. Biomed. Sci. & Biotech., University of Brescia and 1 Dept. Pharmacol.,<br />
Chemother. & Med. Toxicol., University of Milan<br />
EFFECTS OF GHRELIN AND ENDOGENOUS GHRELIN-DERIVATIVES ON<br />
GUINEA PIG HEART<br />
1 Catapano F., 2 Beden<strong>di</strong> I., 1 Tarabra E., 2 Marcantoni A., 1 Pons N., 2 Alloatti G., 1<br />
Muccioli G.<br />
Departments: 1 Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, Division of Me<strong>di</strong>cal<br />
Pharmacology, and 2 Animal and Human Biology, Universiy of Tur<strong>in</strong>, Tur<strong>in</strong>, Italy<br />
EFFECTS OF HIGH GLUCOSE ON GENE EXPRESSION IN ISOLATED RAT<br />
HEARTS<br />
Vitelli M.R., 1 Gaspar<strong>in</strong>i P., Trimarco V., Piegari E., D’Amico M., Rossi F., Berr<strong>in</strong>o L.<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology "L. Donatelli",<br />
Research Center for Car<strong>di</strong>ovascular Diseases; 1 Department of Pathology, Section of<br />
Me<strong>di</strong>cal Genetics. Faculty of Me<strong>di</strong>c<strong>in</strong>e and Surgery, Second University of Naples. Via<br />
Costant<strong>in</strong>opoli, 16 – 80138 Naples<br />
65<br />
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61<br />
45<br />
121<br />
29<br />
145
Poster<br />
n°<br />
221.<br />
222.<br />
223.<br />
224.<br />
225.<br />
226.<br />
227.<br />
EFFECTS OF THE PHYTOESTROGEN GENISTEIN ON THE CIRCULATING<br />
sRANKL-OSTEOPROTEGERIN SYSTEM IN EARLY POSTMENOPAUSAL<br />
WOMEN<br />
Squadrito F, Crisafulli A, M<strong>in</strong>utoli L, Altavilla D, Adamo EB 1 , Mar<strong>in</strong>i R 1 , Mar<strong>in</strong>i H,<br />
Caputi AP<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy; 1 Department of Biochemical, Physiological and Nutritional Sciences<br />
University of Mess<strong>in</strong>a, Italy<br />
EFFECTS ON CYP SUPERFAMILY IN DREISSENA POLYMORPHA EXPOSED<br />
IN SITU TO SUPERFICIAL DRINKING WATER (LAKE TRASIMENO) TREATED<br />
WITH DIFFERENT DISINFECTANTS<br />
Potenza G., Canistro D., Broccoli M., Affatato A., Sapone A., Trespi<strong>di</strong> S., Pozzetti L.,<br />
Biagi G.L., Cantelli-Forti G., Paol<strong>in</strong>i M.<br />
Department of Pharmacology, Alma Mater <strong>Stu<strong>di</strong></strong>orum-University of Bologna, Via<br />
Irnerio 48, 40126 Bologna (Italy)<br />
ENDOGENOUS ACTIVATION OF GROUP II METABOTROPIC GLUTAMATE<br />
RECEPTORS INHIBITS THE HYPOTHALAMIC-PITUITARY-<br />
ADRENOCORTICAL AXIS<br />
Matrisciano F. 1 , Scaccianoce S. 1 , Del Bianco P. 1 ,Caricasole A. 3 , DiGiorgi Gerev<strong>in</strong>i<br />
V 1 , Cappuccio I. 1 , Melchiorri D. 1 , Battaglia G. 2 , Nicoletti F.<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”, Rome Italy, 2 I.N.M Neuromed Pozzilli, Italy, 3 Siena Biotech SpA , Siena<br />
Italy<br />
ESTROGEN AND RALOXIFENE MODULATE LEPTINEMIA AND ADIPOSE<br />
TISSUE OB-R IN OVARIECTOMIZED RATS<br />
Pacilio M, Mattace Raso G, Esposito E, Coppola A, Nasti A * , Di Carlo C*, Meli R, Di<br />
Carlo R.<br />
Department of Experimental Pharmacology, *Department of Obstetrics and<br />
Gynaecology, University of Naples Federico II, Naples, Italy<br />
GENDER DIFFERENCE IN THE CYCLOSPORINE A-INDUCED OSTEOPENIA IN<br />
THE RAT<br />
Pagani F, Lattuada N, Rapetti D, Guidobono F, Sibilia V.<br />
Dept. of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, University of Milano, Italy<br />
GH STIMULATES OPG PRODUCTION IN HUMAN OSTEOBLAST-LIKE CELLS<br />
Mrak E., Villa I., Rub<strong>in</strong>acci A., Lanzi R., Guidobono F.*<br />
Bone Metabolic Unit, Scientific Institute H San Raffaele, Milan, *Dept. Of<br />
Pharmacology, Chemotherapy and Me<strong>di</strong>cal Toxicology, Univ. Of Milan, Milan<br />
G-PROTEIN AND LH ACTION ON CAMP PRODUCTION AND GNRH RELEASE<br />
IN CULTURED HYPOTHALAMIC NEURONS<br />
Mores N, Tr<strong>in</strong>gali G, Navarra P.<br />
Inst. Pharmacol.- Catholic University- Roma- ITALY<br />
66<br />
1 , 2<br />
Abs. book<br />
page<br />
132<br />
113<br />
87<br />
101<br />
101<br />
97<br />
96
Poster<br />
n°<br />
228. METABOTROPIC GLUTAMATE RECEPTOR MGLU5 MODULATES<br />
PANCREATIC ENDOCRINE FUNCTIONS<br />
Storto M. 1 , Capobianco L. 2 , Battaglia G. 2 , Riozzi B 2 ., Lombar<strong>di</strong> A. 2 1 , 2<br />
, Grad<strong>in</strong>i R.<br />
2 , 3<br />
, Nicoletti F.<br />
1 2<br />
Dept. of Sperimental Med. Univ. “La Sapienza” Roma, Italy; I.N.M. Neuromed,<br />
Pozzilli; Italy, 3 Dept. of Human Physiology and Pharmacology, Univ. “La Sapienza”<br />
Roma, Italy<br />
229.<br />
230.<br />
231.<br />
232.<br />
233.<br />
234.<br />
MICROVASCULAR DYSFUNCTIONS IN A STREPTOZOTOCIN-INDUCED<br />
MODEL OF DIABETES: ROLE OF POLY (adp-RIBOSE) POLYMERASE-1 (parp-<br />
1), NITRIC OXIDE SYNTHASE AND CYCLOOXYGENASE-2<br />
Nacci C., Porro C., Potenza M.A., Marasciulo F.L., Montagnani M., Mitolo Chieppa D.<br />
Department of Pharmacology and Human Physiology, Me<strong>di</strong>cal School, University of<br />
Bari<br />
OREXIGENIC EFFECTS OF GHS/GHRELIN AND NITRIC OXIDE IN AGED<br />
RATS: CORRELATION WITH THE HYPOTHALAMIC EXPRESSION OF SOME<br />
NEUROPEPTIDERGIC/RECEPTORIAL EFFECTORS MEDIATING FOOD-<br />
INTAKE<br />
Sara M Bonomo, Antonello E Rigamonti, Diego Scanniffio, Silvano G Cella, Eugenio<br />
E Muller<br />
Department of Me<strong>di</strong>cal Pharmacology, Center of Excellence on Neurodegenerative<br />
Disease, University of Milan, Milan, Italy, 20129<br />
POSTNATAL REPEATED MILD STRESS IN DBA/2J MICE INDUCES<br />
CORTICOSTERONE AND ACTH UNBALANCE, AND REDUCTION OF<br />
EPILEPTIFORM EEG PATTERN IN ADULTS<br />
Giuliani G., Capasso A., Galietta G., Renzi P., Loizzo A.<br />
Istituto Superiore <strong>di</strong> Sanità, Roma; <strong>Università</strong> <strong>di</strong> Roma La Sapienza; and Dipartimento<br />
<strong>di</strong> Scienze Farmaceutiche <strong>Università</strong> <strong>di</strong> Salerno<br />
PYRROLIDINE DITHIOCARBAMATE MODULATES THE SEVERITY OF<br />
CERULEIN IINDUCED MURINE ACUTE PANCREATITIS<br />
Angela De Sarro, Ioannis Virlos, Emanuela Mazzon, Ivana Serra<strong>in</strong>o, Rosanna DiPaola,<br />
Tiziana Genovese, Domenico Britti, Christoph Thiemerman, Ajith Siriwardena,<br />
Salvatore Cuzzocrea<br />
ROLE OF T-LYMPHOCYTES DERIVED OSTEOPROTEGERIN AND RANKL IN<br />
OSTEOPOROSIS INDUCED BY IMMUNOSUPPRESSANTS<br />
Rapetti D, Lattuada D, Lattuada N, Casnici C, Netti C.<br />
Dept. of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, University of Milano, Italy<br />
SHORT-TERM TREATMENT WITH PEPTIDIC GROWTH HORMONE<br />
SECRETAGOGUES STIMULATES CD36 MRNA LEVELS IN A TISSUE-SPECIFIC<br />
FASHION<br />
Bulgarelli I. 1 , Torsello A. 1 , Bresciani E. 1 , Cort<strong>in</strong>ovis S. 1 , Avallone R. 1 , Deghenghi<br />
R. 2 , Locatelli V. 1<br />
1 Department of Experimental, Environmental Me<strong>di</strong>c<strong>in</strong>e and Biotechnology, University<br />
of Milano-Bicocca, Monza, Italy; and 2 Europeptides, Argenteuil, France<br />
67<br />
Abs. book<br />
page<br />
134<br />
98<br />
14<br />
70<br />
45<br />
116<br />
18
Poster<br />
n°<br />
235.<br />
236.<br />
237.<br />
238.<br />
THE USE OF ANTISENSE OLIGONUCLEOTIDES (aODNS) TO MODULATE THE<br />
BZ-SSAO ACTIVITY OF 3T3-L1 CELLS<br />
L. Raimon<strong>di</strong>, A. Quattrone 1 , G. Banchelli, A. Men<strong>di</strong>c<strong>in</strong>o, L. Corti, R. Piris<strong>in</strong>o<br />
Dept. of Pharmacology, University of Florence, Italy. 1 Nuova Casa Della Sofferenza, S.<br />
Giovanni Rotondo, Foggia, Italy<br />
TREATMENT OF BULIMIA NERVOSA WITH SERTRALINE: A RANDOMIZED<br />
CONTROLLED TRIAL<br />
Sabat<strong>in</strong>o C., Milano W. 1 , Petrella C. 1 , Capasso A.<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Salerno, Via Ponte Don Melillo<br />
(84084) Fisciano, Salerno and 1 Unità Operativa <strong>di</strong> Salute Mentale Distretto 44 ASL<br />
Napoli 1, Italia<br />
VALPROIC ACID INHIBITS CORTICOTROPHIN-RELEASING HORMONE<br />
PRODUCTION FROM THE RAT HYPOTHALAMUS IN VITRO<br />
Tr<strong>in</strong>gali G 1 , Aubry J M 2 , Moscianese K 3 , Zamori C 1 , Navarra P 1 , Pozzoli G 1<br />
1 Institute of Pharmacology, Catholic University School of Me<strong>di</strong>c<strong>in</strong>e, Rome, Italy, 2<br />
Dept. de Psychiatrie, HUG, Geneva, Switzerland and 3 Dept. of Psychiatry, ASL-RM C,<br />
Rome, Italy.<br />
VASCULAR ENDOTHELIAL GROWTH FACTOR GENE TRANSFER<br />
STIMULATES ANGIOGENESIS AND WOUND HEALING IN THE<br />
GENETICALLY DIABETIC MOUSE<br />
Deodato B, M<strong>in</strong>utoli L, Mar<strong>in</strong>i H, Bitto A, Passaniti M, Giacca M 1 , Altavilla D<br />
,Caputi AP, Squadrito F<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy. 1 Molecular Me<strong>di</strong>c<strong>in</strong>e Laboratory, International Centre for Genetic<br />
Eng<strong>in</strong>eer<strong>in</strong>g and Biotechnology (ICGEB), Trieste, Italy<br />
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115<br />
123<br />
140<br />
44
SABATO 28 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 8.30 – 10.30<br />
MINISIMPOSIO: Meccanismi trasduzionali e trascrizionali nell’azione dei farmaci antidepressivi<br />
ed antipsicotici.<br />
Moderatori: N. Brunello (Modena) - G. Racagni (Milano)<br />
8.30 Modulazione <strong>di</strong> fattori neurotrofici da parte <strong>di</strong> farmaci psicotropi.<br />
F. Fumagalli (Milano)<br />
8.50 Co<strong>in</strong>volgimento del fattore <strong>di</strong> trascrizione CREB nel meccanismo d’azione dei farmaci<br />
antidepressivi.<br />
F. Tascedda (Modena)<br />
9.10 Meccanismi molecolari <strong>di</strong> plasticità s<strong>in</strong>aptica nell’azione dei farmaci antidepressivi.<br />
M. Popoli (Milano)<br />
9.30 Effetti del trattamento cronico con antidepressivi sulla trasmissione glutammatergica.<br />
G. Bonanno (Genova)<br />
9.50 Farmacogenetica dei farmaci stabilizzanti dell’umore e <strong>degli</strong> antipsicotici.<br />
M. Gennarelli (Brescia)<br />
69
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 8.30 – 10.30<br />
SESSIONE DI COMUNICAZIONI ORALI: Immunofarmacologia<br />
Moderatori: M.C. Fioretti (Perugia) – R. Fantozzi (Tor<strong>in</strong>o)<br />
Ore Abs. book<br />
page<br />
8.30 EFFECT OF ACUTE AND CHRONIC MORPHINE ADMINISTRATION ON<br />
MACROPHAGE AND TH1/TH2 CYTOKINE PRODUCTION IN THE MOUSE<br />
Sacerdote P., Martucci C., Panerai AE.<br />
Dept. Pharmacology, University of Milano, Milano<br />
8.45 SIGNALS THROUGH THE TNFR SUPERFAMILY (TNFRSF) MEMBER GITR<br />
ARE COSTIMULATORY TO T LYMPHOCYTES<br />
Ronchetti S., Nocent<strong>in</strong>i G., Cannarile L., Bruscoli S., Marchetti C., Riccar<strong>di</strong> C.<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology,<br />
University of Perugia, Via del Giochetto, 06100 Perugia, Italy<br />
9.00 THE INTRINSIC CATECHOLAMINERGIC SYSTEM OF HUMAN<br />
LYMPHOCYTES: INVOLVEMENT IN MULTIPLE SCLEROSIS AND<br />
POSSIBLE RELEVANCE FOR THE EFFECTS OF INTERFERONS<br />
Mar<strong>in</strong>o F., Cosent<strong>in</strong>o M., # Zaffaroni M., Ferrari M., Bombelli R., Lecch<strong>in</strong>i S., Ras<strong>in</strong>i<br />
E., # Ghezzi A., Frigo G.M.<br />
Laboratory of Pharmacology, Centre for Research <strong>in</strong> Cl<strong>in</strong>ical and Applied<br />
Pharmacology, University of Insubria and University of Pavia, Varese and # MS Study<br />
Centre, Gallarate VA, Italy<br />
9.15 GROUP I METABOTROPIC GLUTAMATE RECEPTORS PROTECT HUMAN T<br />
LYMPHOCYTES FROM ACTIVATION-INDUCED CELL DEATH<br />
Miglio G. a , Mocell<strong>in</strong> M. a , Varsal<strong>di</strong> F. a , Chiocchetti A. b , Dianzani U. b , Lombar<strong>di</strong> G. a<br />
a DISCAFF and b Me<strong>di</strong>cal Science Departments, University of “Piemonte Orientale”,<br />
Novara, Italy<br />
9.30 THE TRYPTOPHAN METABOLIC PATHWAY AS A NEW PHARMACOLOGIC<br />
TARGET: DUAL PERSPECTIVES FOR IMMUNOTHERAPY<br />
Grohmann U, Fallar<strong>in</strong>o F, Orabona C, Bianchi R, Vacca C, Belladonna ML, Fioretti<br />
MC, Puccetti P<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e and Biochemical Sciences, University of<br />
06126 Perugia<br />
9.45 PREVENTION OF ANTIGEN-INDUCED BRONCHOCOSTRICTION BY<br />
INHIBITION OF (ADP-RIBOSE)POLYMERASE, IN ACTIVELY SENSITIZED<br />
GUINEA PIGS<br />
Di Felice A., Pierpaoli S., Vannacci A., Giann<strong>in</strong>i L., Marzocca C., Zagli G.,<br />
Mannaioni P.F., Suzuki,H., Cuzzocrea S., Bani D., Mas<strong>in</strong>i E.<br />
Dpts of Pharmacology, Anatomy, Histology and Forensic Me<strong>di</strong>c<strong>in</strong>e, University of<br />
Florence, Institute of Pharmacology, University of Mess<strong>in</strong>a, Pe<strong>di</strong>atric Cl<strong>in</strong>ic and<br />
Department of Neurology, Unversity of Verona, Italy<br />
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93<br />
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page<br />
10.00 Nf-kB REGULATES CELL SURVIVAL IN CHRONIC GRANULOMATOUS<br />
INFLAMMATION<br />
Maiuri MC, Iuvone T, De Stefano D, *Tajana G, Carnuccio R<br />
Department of Experimental Pharmacology, University of Naples “Federico II”;<br />
*Department of Pharmaceutical Sciences, University of Salerno<br />
10.15 SUBTLE SHIFTS IN THE RATIO BETWEEN PRO- AND ANTI-APOPTOTIC<br />
MOLECULES DECIDE THE FATE OF DOUBLE POSITIVE (CD4 + CD8 + )<br />
THYMOCYTES FOLLOWING DEXAMETHASONE TREATMENT<br />
Nocent<strong>in</strong>i G., Bianch<strong>in</strong>i R., Ronchetti S., Utrilla P., Ayrol<strong>di</strong> E., Riccar<strong>di</strong> C.<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology,<br />
University of Perugia, Via del Giochetto, 06100 Perugia, Italy<br />
71<br />
81<br />
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SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA I A<br />
Ore 8.30 – 10.30<br />
MINISIMPOSIO: La placca aterosclerotica <strong>in</strong>stabile: meccanismi cellulari e molecolari e<br />
modulazione farmacologica.<br />
Moderatori: F. Rossi (Napoli) - R. Paoletti (Milano)<br />
8.30 La placca <strong>in</strong>stabile <strong>in</strong> car<strong>di</strong>ologia: fisiopatologia delle s<strong>in</strong>dromi coronariche acute.<br />
M. Chiariello (Napoli)<br />
8.50 Placca <strong>in</strong>stabile e tissue factor.<br />
P. Gol<strong>in</strong>o (Napoli)<br />
9.10 Le lipoprote<strong>in</strong>e mo<strong>di</strong>ficate nell’aterosclerosi.<br />
A. Catapano (Milano)<br />
9.30 Ruolo dell’attivazione specifica <strong>di</strong> l<strong>in</strong>fociti T nella placca <strong>in</strong>stabile.<br />
R. De Palma (Napoli)<br />
9.50 E’ possibile stabilizzare farmacologicamente la placca <strong>in</strong>stabile?<br />
E. Tremoli (Milano)<br />
10.10 Ruolo delle HDL nella stabilizzazione della placca.<br />
C. Sirtori (Milano)<br />
72
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA I B<br />
Ore 8.30 – 10.30<br />
MINISIMPOSIO: Nuove prospettive farmacologiche <strong>di</strong> terapia nelle tossico<strong>di</strong>pendenze.<br />
Moderatori: G.L. Gessa (Cagliari) - W. Fratta (Cagliari)<br />
8.30 Proprietà antialcol del Baclofen: evidenze precl<strong>in</strong>iche.<br />
G. Colombo (Cagliari)<br />
9.00 Proprietà antialcol del Baclofen: evidenze cl<strong>in</strong>iche.<br />
G. Addolorato (Roma)<br />
9.30 Interazioni cannab<strong>in</strong>oi<strong>di</strong>-oppioi<strong>di</strong> nei meccanismi <strong>di</strong> “relapse” all’abuso <strong>di</strong> sostanze.<br />
W. Fratta (Cagliari)<br />
10.00 Una rivisitazione del Disulfiram: un nuovo meccanismo d’azione nella <strong>di</strong>pendenza da alcol<br />
e coca<strong>in</strong>a.<br />
G.L. Gessa (Cagliari)<br />
73
SABATO 28 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 11.00 – 13.00<br />
MINISIMPOSIO: Verso farmaci antiepilettici <strong>di</strong> terza generazione.<br />
Moderatori: E. Perucca (Pavia) – G. Avanz<strong>in</strong>i (Milano)<br />
In collaborazione con la Lega Italiana Contro l’Epilessia<br />
11.00 Dieci anni <strong>di</strong> esperienza cl<strong>in</strong>ica con i “nuovi” antiepilettici: quale bilancio?<br />
E. Perucca (Pavia)<br />
11.30 Verso farmaci antiepilettici <strong>di</strong> nuova generazione: nuovi bersagli molecolari e nuovi<br />
modelli sperimentali.<br />
G.B. De Sarro (Catanzaro)<br />
12.00 Dalle evidenze precl<strong>in</strong>iche allo sviluppo cl<strong>in</strong>ico: problemi e soluzioni nello sviluppo <strong>di</strong> un<br />
nuovo antiepilettico.<br />
R. Fariello (Bresso)<br />
12.30 Neuroprotezione, “<strong>di</strong>sease mo<strong>di</strong>fication” e antiepilettogenesi: curiosità sperimentali o reali<br />
prospettive cl<strong>in</strong>iche?<br />
G. Avanz<strong>in</strong>i (Milano)<br />
74
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
11.00 – 13.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Farmacologia delle funzioni <strong>di</strong>gestive e respiratorie<br />
Moderatori: G. Guarnieri (Trieste) – M. Carruba (Milano)<br />
Ore Abs. book<br />
page<br />
11.00 IN VITRO EFFECT OF A PEPTIDE ACTIVATING PAR2 (PAR2-AP) ON<br />
AIRWAYS OF LPS-TREATED RATS<br />
1 1 2 3 2 1<br />
Cicala C., Morello S., Maffia P., Cuzzocrea S., Roviezzo F., Cir<strong>in</strong>o G.<br />
1 2<br />
Dipartimento <strong>di</strong> Farmacologia Sperimentale, <strong>Università</strong> <strong>di</strong> Napoli “Federico II;<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Salerno; 3 Dipartimento Cl<strong>in</strong>ico<br />
Sperimentale <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Farmacologia, <strong>Università</strong> <strong>di</strong> Mess<strong>in</strong>a<br />
11.15 PROFILES OF EICOSANOIDS IN EXHALED BREATH CONDENSATE IN<br />
CHILDHOOD ASTHMA<br />
1 Montuschi P., 2 Mond<strong>in</strong>o C., 3 Koch P., 4 Ciabattoni G.<br />
1 Department of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, Catholic University of the<br />
Sacred Heart, Rome, 2 Immunodermatology, Istituto Dermopatico dell’Immacolata,<br />
IDI, IRCCS, Rome, 3 Pulmonology, Ospedale Pe<strong>di</strong>atrico Bamb<strong>in</strong>o Gesù, Palidoro, 4<br />
Department of Drug Sciences, School of Pharmacy, University of Chieti<br />
11.30 CELLULAR SIGNALLING OF Bv8/PK RECEPTORS.<br />
Di Giovanni S.,.Giann<strong>in</strong>i E., Negri L., Melchiorri P.<br />
Department of Human Physiology and Pharmacology, University “La Sapienza”,<br />
Rome, Italy<br />
11.45 CYCLOOXYGENASE ISOFORMS REGULATE COLONIC MOTILITY IN<br />
DIFFERENT EXPERIMENTAL MODELS<br />
1 1 1 2 2 1<br />
Fornai M., Antonioli L., Blan<strong>di</strong>zzi C., Baragatti B., Barogi S., Del Tacca<br />
M.<br />
1<br />
Division of Pharmacology and Chemotherapy, Department of Oncology,<br />
Transplants and Advanced Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e, University of Pisa; 2<br />
Laboratory of Physiological Genomics, Institute of Cl<strong>in</strong>ical Physiology, National<br />
Research Council and Superior School of University <strong>Stu<strong>di</strong></strong>es St. Anne, Pisa, Italy<br />
12.00 EFFECT OF CAFFEIC ACID PHENETHYL ESTER ON GASTRIC ACID<br />
SECRETION IN VITRO<br />
Borrelli F., Capasso R., Di Carlo G., Izzo A.A., Mascolo N., Posadas I., Capasso F.<br />
Department of Experimental Pharmacology, University of Naples “Federico II”, Via<br />
D. Montesano 49, 80131 Naples, Italy<br />
12.15 ROLE OF MITOGEN ACTIVATED PROTEIN-KINASES (MAPK) IN THE<br />
DEVELOPMENT OF CERULEIN INDUCED PANCREATITIS<br />
M<strong>in</strong>utoli L, Bitto A, Sem<strong>in</strong>ara P, Mar<strong>in</strong>i H, Altavilla D, Caputi AP; Squadrito F.<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy<br />
75<br />
32<br />
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48<br />
59<br />
14<br />
94
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page<br />
12.30 GHRELIN PROTECTS AGAINST ETHANOL-INDUCED GASTRIC DAMAGE:<br />
ROLE OF NITRIC OXIDE<br />
Lattuada N 1 , Bulgarelli I 2 , Rapetti D 1 , Pagani F 1 , Sibilia V 1 .<br />
1 Dept. of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, University of Milano, Italy; 2 Dept of<br />
Experimental and Enviromental Me<strong>di</strong>c<strong>in</strong>e and Biotechnology, University of Milano-<br />
Bicocca, Italy<br />
12.45 APAMIN, BUT NOT THE P2-PURINOCEPTOR ANTAGONIST PPADS OR<br />
DESENSITIZATION TO ATP, INHIBITS THE NON-ADRENERGIC NON-<br />
CHOLINERGIC RELAXATION OF THE RAT GASTRIC FUNDUS<br />
Currò D., De Marco T.<br />
Institute of Pharmacology, School of Me<strong>di</strong>c<strong>in</strong>e, Catholic University of the Sacred<br />
Heart, Rome, Italy<br />
76<br />
77<br />
39
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA I A<br />
Ore 11.00 – 13.00<br />
MINISIMPOSIO: Rischio car<strong>di</strong>ovascolare: meccanismi <strong>di</strong> danno e <strong>di</strong> protezione.<br />
Moderatori: F. Ledda (Firenze) - A. Filippelli (Napoli)<br />
11.00 Meccanismi del danno miocar<strong>di</strong>co da ischemia/riperfusione nel <strong>di</strong>abete.<br />
M. D’Amico (Napoli)<br />
11.15 Iperglicemia, stress ossidativo e <strong>di</strong>sfunzione car<strong>di</strong>aca.<br />
L. Berr<strong>in</strong>o (Napoli)<br />
11.30 Danno endoteliale, deficit <strong>di</strong> ossigeno e rimodellamento vascolare.<br />
A. Parenti (Firenze)<br />
11.45 Diagnosi e trattamento del danno vascolare precl<strong>in</strong>ico nell’ ipertensione arteriosa.<br />
E. Agabiti Rosei (Brescia)<br />
12.00 Diabete, obesità e rischio car<strong>di</strong>ovascolare.<br />
D. Giugliano (Napoli), R. Marfella (Napoli)<br />
12.15 Diabete, ed ipertensione: nuove strategie terapeutiche.<br />
B. Trimarco (Napoli), C. Morisco (Napoli)<br />
12.30 La prevenzione del rischio car<strong>di</strong>ovascolare nel paziente <strong>di</strong>abetico.<br />
E. Carluccio (Perugia)<br />
77
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA I B<br />
Ore 11.00 – 13.00<br />
MINISIMPOSIO: Il crav<strong>in</strong>g: dalla neurobiologia alla terapia.<br />
Moderatore: G. Di Chiara (Cagliari)<br />
11.00 Def<strong>in</strong>izione e neurobiologia del crav<strong>in</strong>g.<br />
G. Di Chiara (Cagliari)<br />
11.30 Modelli sperimentali <strong>di</strong> crav<strong>in</strong>g e validazione cl<strong>in</strong>ica.<br />
P. Nenc<strong>in</strong>i (Roma)<br />
12.00 Significato cl<strong>in</strong>ico del crav<strong>in</strong>g.<br />
I. Maremmani (Pisa)<br />
12.30 Ruolo del crav<strong>in</strong>g nella terapia delle tossico<strong>di</strong>pendenze.<br />
P.P. Pani (Cagliari)<br />
78
SABATO 28 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 16.00 – 18.00<br />
MINISIMPOSIO: Regolazione delle funzioni gastro<strong>in</strong>test<strong>in</strong>ali: prospettive per nuove terapie<br />
farmacologiche.<br />
Moderatori: M. Del Tacca (Pisa) - M. Ton<strong>in</strong>i (Pavia)<br />
16.00 Il sistema nervoso enterico: organizzazione anatomo-funzionale.<br />
M. Costa (Adelaide)<br />
16.15 Plasticità e adattamento neuronale: basi farmacologiche.<br />
F. De Ponti (Bologna)<br />
16.30 Modelli <strong>di</strong> <strong>in</strong>fiammazione e loro implicazioni cl<strong>in</strong>ico-terapeutiche.<br />
P. Geppetti (Ferrara)<br />
16.45 Farmaci <strong>in</strong>ibitori delle ciclo-ossigenasi e funzioni neuro-motorie.<br />
C. Blan<strong>di</strong>zzi (Pisa)<br />
17.00 S<strong>in</strong>dromi <strong>di</strong>gestive funzionali: ruolo della seroton<strong>in</strong>a.<br />
M. Ton<strong>in</strong>i (Pavia<br />
17.15 Farmaci attivi sulla percezione viscerale.<br />
R. De Giorgio (Bologna)<br />
17.30 Terapie farmacologiche delle s<strong>in</strong>dromi <strong>di</strong>gestive funzionali.<br />
C. Scarpignato (Parma)<br />
79
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 16.00 – 18.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Chemioterapia II<br />
Moderatori: I. Viano (Novara) - G. M<strong>in</strong>otti (Chieti)<br />
Ore Abs. book<br />
page<br />
16.00 THE NOVEL ANTHRACYCLINE MEN 10755 IS LESS CARDIOTOXIC THAN<br />
DOXORUBICIN OR EPIRUBICIN DUE TO REDUCED FORMATION AND<br />
ACONITASE-REACTIVITY OF ITS SECONDARY ALCOHOL METABOLITE<br />
Menna P, Salvatorelli E, Giampietro R, *Bertani N, *Graiani G, ‡ Animati F, ‡ Goso<br />
C, ‡ Maggi CA, ‡ Manz<strong>in</strong>i S, ‡ Sacco G, M<strong>in</strong>otti G<br />
Center of Excellence on Ag<strong>in</strong>g, University of Chieti Sch. of Me<strong>di</strong>c<strong>in</strong>e; *Department<br />
of Pathology, University of Parma Sch. of Me<strong>di</strong>c<strong>in</strong>e; ‡ Menar<strong>in</strong>i Ricerche S.pA.,<br />
Pomezia (Rome)<br />
16.15 THE EXPRESSION OF THE PHOSPHOTYROSINE PHOSPHATASE DEP-<br />
1/PTPh DICTATES THE RESPONSIVITY OF GLIOMA CELLS TO<br />
SOMATOSTATIN INHIBITION OF CELL PROLIFERATION<br />
Massa A. 1 , Barbieri F. 2 , Aiello C. 2 , Arena S. 1 , Pattarozzi A. 1 , Pirani P. 2 , Corsaro<br />
A. 1 , Iuliano R. 3 , Fusco A. 3 , Spaziante R. 4 , Schett<strong>in</strong>i G 1 , 2 1 , 2<br />
, Florio T<br />
1 2<br />
Sect. Pharmacology Dept. Oncology Biology and Genetics, Univ Genova,<br />
Pharmacology and Neuroscience, National Institute for Cancer Research (IST), 3<br />
Dept. Cl<strong>in</strong> and Exp Me<strong>di</strong>c<strong>in</strong>e, Univ Catanzaro, 4 Dip. Neurosci., Opht. and Genetics<br />
Univ Genova Italy<br />
16.30 RESISTANCE TO ANTIANGIOGENIC CHEMOTHERAPY: ROLE OF PI3K/AKT<br />
SIGNALLING PATHWAY<br />
Benedetta Bussolati, Giovanni Camussi*, Francesco Di Carlo<br />
Dipartimento <strong>di</strong> Scienze Cl<strong>in</strong>iche e Biologiche and *Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a<br />
Interna, <strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o, Italy<br />
16.45 EFFECTS OF p53 AND p21 MODULATION ON THE RESPONSE OF HUMAN<br />
COLON CANCER CELLS TO DOXORUBICIN<br />
Monti E., Ravizza R., Cereda E., Garibol<strong>di</strong> M.B.<br />
Dipartimento <strong>di</strong> Biologia Strutturale e Funzionale – <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong><br />
dell’Insubria, Busto Arsizio (Varese)<br />
17.00 PALONOSETRON (RS-25259-197), A HIGHLY EFFECTIVE ANTIEMETIC<br />
DRUG, DOES NOT ALTER THE ANTINEOPLASTIC ACTION OF VARIOUS<br />
CHEMOTHERAPEUTICS IN TUMOR BEARING RODENTS<br />
Barone D. 1 , Toso E. 1 , Cantoreggi S. 2 , Parisi S. 2<br />
1<br />
LCG-RBM, Via Ribes 1 – 10010 Colleretto Giacosa, (TO) Italy;<br />
Healthcare, P.O. Box 357, 6915 - Pambio-Noranco, Switzerland<br />
2<br />
Hels<strong>in</strong>n<br />
80<br />
91<br />
87<br />
19<br />
95<br />
8
Ore Abs. book<br />
page<br />
17.15 RECOGNITION OF EEF1A BY CYTOTOXIC GT OLIGOMERS AS NEW<br />
POTENTIAL STRATEGY USEFUL FOR THE IDENTIFICATION OF<br />
HEMATOPOIETIC CANCER CELLS<br />
Dapas B., Periss<strong>in</strong> L, Scaggiante B.<br />
Dept.of Biome<strong>di</strong>cal Sciences and Technologies, University of Ud<strong>in</strong>e<br />
17.30 EXPRESSION OF GHRELIN AND ITS RECEPTORS IN HUMAN PROSTATE<br />
CANCER<br />
1 Ghè C., 2 Cassoni P., 1 Tarabra E., 2 Allia E., 2 Papotti M., 1 Muccioli G.<br />
Departments: 1 Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, Division of Me<strong>di</strong>cal<br />
Pharmacology, and 2 Biome<strong>di</strong>cal Sciences and Oncology, Division of Pathology,<br />
Universiy of Tur<strong>in</strong>, Tur<strong>in</strong>, Italy<br />
17.45 EFFECT OF ENDOTHELIN-1 ON INTRACELLULAR GLUTATHIONE AND<br />
LIPID PEROXIDATION IN HUMAN CHORION CARCINOMA CELLS (JEG3)<br />
1 Micheli L., 2 Fiore G., 1 Nenc<strong>in</strong>i C., 2 Rossi M., 2 Florio P., 2 Ciarmela P., 1<br />
Cerretani D., 2 Petraglia F., 1 Giorgi G.<br />
1 2<br />
Dipartimento <strong>di</strong> Farmacologia “Giorgio Segre”, Dipartimento <strong>di</strong> Pe<strong>di</strong>atria,<br />
Ostetricia e Me<strong>di</strong>c<strong>in</strong>a della Riproduzione, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena<br />
81<br />
40<br />
67<br />
92
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 1 A<br />
Ore 16.00 – 18.00<br />
MINISIMPOSIO: La farmacologia dei PUFA n-3: dall’igloo al laboratorio alla pratica cl<strong>in</strong>ica.<br />
Moderatori: R. Paoletti (Milano) - A.P. Maggioni (Firenze)<br />
Coord<strong>in</strong>atore: A. Mugelli (Firenze)<br />
16.00 Dalla chimica alla evidenza cl<strong>in</strong>ica.<br />
R. Marchioli (Chieti)<br />
16.20 Gli aci<strong>di</strong> grassi omega 3: caratteristiche metaboliche e proprietà funzionali.<br />
C. Galli (Milano)<br />
16.40 PUFA n-3: effetti anti-aterogeni.<br />
R. De Cater<strong>in</strong>a (Chieti)<br />
17.00 PUFA n-3: effetti antitrombotici.<br />
E. Tremoli (Milano)<br />
17.20 PUFA n-3: effetti antiaritmogenici.<br />
A. Mugelli (Firenze)<br />
17.40 PUFA n-3 nella pratica cl<strong>in</strong>ica e prospettive.<br />
A.P. Maggioni (Firenze)<br />
82
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 1 B<br />
Ore 16.00 – 18.00<br />
MINISIMPOSIO: Malattie neurodegenerative: meccanismi patogenetici e farmaci.<br />
Moderatori: G. Pepeu (Firenze) – E. Ong<strong>in</strong>i (Bresso)<br />
16.00 Hunt<strong>in</strong>gton: una malattia “modello”.<br />
E. Cattaneo (Milano)<br />
16.20 <strong>Stu<strong>di</strong></strong>o dei meccanismi alla base dell’apoptosi neuronale <strong>in</strong> un modello sperimentale <strong>di</strong><br />
neuroAIDS.<br />
G. Bagetta (Arcavata <strong>di</strong> Rende)<br />
16.40 Effetti terapeutici e neuroprotettivi <strong>degli</strong> antagonisti dei recettori A2 dell’adenos<strong>in</strong>a <strong>in</strong><br />
modelli animali <strong>di</strong> morbo <strong>di</strong> Park<strong>in</strong>son.<br />
M. Morelli (Cagliari)<br />
17.00 Neuro<strong>in</strong>fiammazione e malattia <strong>di</strong> Alzheimer. Nuovi approcci farmacologici <strong>in</strong> modelli<br />
animali <strong>in</strong> vivo.<br />
F. Casamenti (Firenze)<br />
17.20 Metabolismo del precursore <strong>di</strong> beta amiloide ed <strong>in</strong>ibizione dell’acetilcol<strong>in</strong>esterasi nella<br />
malattia <strong>di</strong> Alzheimer.<br />
M. Racchi (Pavia)<br />
17.40 Nuovi farmaci anti<strong>in</strong>fiammatori con proprietà antiossidanti: una prospettiva per la terapia<br />
della malattia <strong>di</strong> Alzheimer.<br />
L. Gaspar<strong>in</strong>i (Bresso)<br />
83
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 2C<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Chemioterapia antivirale, antibatterica ed ant<strong>in</strong>eoplastica.<br />
POSTER 239-256<br />
Moderatori: S. Milani (Trieste) – F. Bartoli (Trieste).<br />
Poster<br />
n°<br />
239.<br />
240.<br />
241.<br />
242.<br />
243.<br />
A PHARMACOKINETIC-BASED TEST TO PREDICT THE RISK OF LIFE-<br />
THREATENING 5-FLUOROURACIL TOXICITIES IN CANCER PATIENTS<br />
1 Bocci G, 1 Di Paolo A, 2 Melosi A, 2 Battistoni M, 2 Barsanti G, 1 Del Tacca M<br />
1 Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants<br />
and Advanced Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e, University of Pisa, Pisa; 2 Division of<br />
Me<strong>di</strong>cal Oncology, General Hospital, Lucca, Italy<br />
CHEMOTHERAPY AND PHARMACOGENETICS OF GEMCITABINE IN<br />
LYMPHOID TUMOR CELLS<br />
1 1 1 1 1 2 1<br />
Loni L, Giovannetti E, Mey V, Danesi R, Savar<strong>in</strong>o G, Barsanti G, Del<br />
Tacca M<br />
1<br />
Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants<br />
and Advanced Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e, University of Pisa; 2 Division of Me<strong>di</strong>cal<br />
Oncology, General Hospital, Campo <strong>di</strong> Marte, Lucca, Italy<br />
CHEMOHYPERTHERMIC INTRAPERITONEAL PERFUSION (IHCP) WITH<br />
MITOMYCIN C AFTER RESECTION OF PERITONEAL CARCINOMATOSIS:<br />
PHARMACOKINETICS STUDY<br />
Cerretani D. 1 , Roviello F. 2 , Nenc<strong>in</strong>i C. 1 , Urso R. 1 , De Stefano A. 2 , Marrelli D. 2 ,<br />
P<strong>in</strong>to E. 2 , Nastri G. 2 , Cioppa T. 2 , Giorgi G. 1<br />
1 2<br />
Department of Pharmacology “G. Segre”, University of Siena; Unit of Surgical<br />
Oncolgy, University of Siena<br />
FLOW CYTOMETRIC ANALYSIS OF CHEMORESISTANCE RELATED<br />
PROTEINS IN MALIGNANT GLIOMA<br />
Calatozzolo C. 1 , Gelati M. 1 , Ciusani E. 1 , Sciacca F. 1 , Pollo B. 2 , Marras C. 3 ,<br />
Boiar<strong>di</strong> A. 4 , Croci D. 1 , Salmaggi A. 4<br />
1 Dept. Cl<strong>in</strong>ical Investigation, 2 Lab. of Neuropathology, 3 Dept. of Neurosurgery, 4<br />
Dept. of Neurosciences , National Neurologic Institute “Carlo Besta”, Milan, Italy<br />
INHIBITORY EFFECT OF PERILLYL ALCOHOL ON SMC PROLIFERATION: IN<br />
VITRO AND IN VIVO STUDIES<br />
C. Comparato, R. Baetta, F. Silva, L. Arnabol<strong>di</strong>, N. Ferri, A. Granata, A. Cors<strong>in</strong>i.<br />
Department of Pharmacological Sciences, University of Milan, Italy<br />
84<br />
Abs. book<br />
page<br />
13<br />
80<br />
30<br />
20<br />
36
Poster<br />
n°<br />
244.<br />
245.<br />
246.<br />
247.<br />
248.<br />
249.<br />
MATRIX-METALLOPROTEINASES AND CYSTEINE PROTEINASES<br />
CIRCULATING LEVELS IN PATIENTS WITH SKELETAL METASTASES FROM<br />
BREAST OR PROSTATE CANCER TREATED WITH ZOLEDRONIC ACID<br />
Leto G., Fulfaro F., Arcara C., Badalamenti G., Crescimanno M., Fland<strong>in</strong>a C.,<br />
Tumm<strong>in</strong>ello F.M., Vitale R., Vizz<strong>in</strong>i L., Gebbia N.<br />
Sect. Chemother., Dept. Oncol. Policl<strong>in</strong>ico P. Giaccone, 90127 Palermo<br />
PHARMACOGENETIC DETERMINANTS OF RESPONSE TO TEMOZOLOMIDE<br />
IN MALIGNANT GLIOMAS<br />
Acerbi F 2 , Orlan<strong>di</strong> P 1 , Danesi R 1 , Parenti G°°, Del Tacca M 1<br />
2 Sant'Anna School of University <strong>Stu<strong>di</strong></strong>es and Doctoral Research, Pisa; 1 Division of<br />
Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced<br />
Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e, University of Pisa; 3 Division of Neurosurgery, Department<br />
of Neuroscience, University of Pisa, Italy<br />
PHARMACOGENETICS OF THYMIDYLATE SYNTHASE AND<br />
DIHYDROPYRIMIDINE DEHYDROGENASE IN COLORECTAL CANCER<br />
1 Vannozzi F, 2 Boldr<strong>in</strong>i L, 1 Amatori F, 3 Gisfre<strong>di</strong> S, 1 Lastella M, 1 Di Paolo A, 1<br />
Danesi R, 1 Del Tacca M<br />
1 Division of Pharmacology and Chemotherapy, and 3 Division of Pathological<br />
Anatomy, Department of Oncology, Transplants and Advanced Technologies <strong>in</strong><br />
Me<strong>di</strong>c<strong>in</strong>e; 3 Department of Surgery, University of Pisa, Italy<br />
PHARMACOSURVEILLANCE OF ADVERSE DRUG REACTIONS INDUCED BY<br />
GEMCITABINE TREATMENT IN PATIENTS WITH NON SMALL CELL LUNG<br />
CANCER<br />
Gallelli L 1 , Nar<strong>di</strong> M 2 , Prantera T 3 , Barbera S 4 , Raffaele M 2 , Arm<strong>in</strong>io D 3 , Pirritano<br />
D 1 , De Gregorio P 1 , De Sarro GB 1<br />
1 Chair of Pharmacology Department of Exp. and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, University of<br />
Catanzaro, Regional Pharmacovigilance Center; 2 Division of Me<strong>di</strong>cal Oncology<br />
Ospedali Riuniti of Reggio Calabria; 3 Operative Units of Oncology, Crotone Hospital; 4<br />
Division of Pneumology “Mariano Santo” Cosenza Hospital<br />
SYNERGISTIC ANTIPROLIFERATIVE ACTIVITY OF GEMCITABINE AND<br />
PEMETREXED ASSOCIATION AGAINST LUNG AND PANCREATIC CANCER<br />
CELLS<br />
Giovannetti E, Mey V, Danesi R, Del Tacca M<br />
Division of Phamacology and Chemotherapy, Department of Oncology, Transplants<br />
and Advanced Technologies <strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e, University of Pisa, Italy<br />
TELOMERASE ACTIVITY IN BIOLOGICAL LUNG SPECIMENS: DIAGNOSTIC<br />
MARKER AND INDICATIONS FOR THERAPY<br />
Colangelo D. 1 , Ghiglia A. 1 , Casa<strong>di</strong>o C. 2 , Vandone A. 2 , Crist<strong>in</strong>a S. 2 , Crisp<strong>in</strong>o L. 3 ,<br />
Viano I. 1<br />
1 Dip. Scienze Me<strong>di</strong>che, Facoltà Me<strong>di</strong>c<strong>in</strong>a e Chirurgia, <strong>Università</strong> del Piemonte<br />
Orientale “A.Avogadro”, Novara; 2 Ospedale Magg. della Carità, Novara, Cl<strong>in</strong>ica <strong>di</strong><br />
Chirurgia Generale e Anatomia Patologica; 3 <strong>Università</strong> “Federico II”, Napoli<br />
85<br />
Abs. book<br />
page<br />
78<br />
1<br />
142<br />
63<br />
69<br />
35
Poster<br />
n°<br />
250.<br />
251.<br />
252.<br />
253.<br />
254.<br />
255.<br />
UFT PLUS OXALIPLATIN OR IRINOTECAN COMBINATION CHEMOTHERAPY<br />
IN THE FIRST-LINE TREATMENT OF ADVANCED COLORECTAL CANCER:<br />
PHARMACOKINETIC STUDY OF TEGAFUR AND 5FU<br />
1 1 1 2 2 1<br />
Fiaschi A.I., Cerretani D., Urso R., Petrioli R., Franc<strong>in</strong>i G., Giorgi G.<br />
1 2<br />
Dipartimento <strong>di</strong> Farmacologia “G. Segre”, <strong>Università</strong> <strong>degli</strong> stu<strong>di</strong> <strong>di</strong> Siena, Siena;<br />
Dipartimento <strong>di</strong> Patologia Umana ed Oncologia, <strong>Università</strong> <strong>degli</strong> stu<strong>di</strong> <strong>di</strong> Siena, Siena<br />
ANTIBIOTIC PROPHYLAXIS IN SURGERY: AN OBSERVATIONAL<br />
PROSPECTIVE STUDY CONDUCTED IN THE SECOND UNIVERSITY OF<br />
NAPLES<br />
F. Mazzeo, A. Capuano, A. Avolio, S. Noviello 1 , F. Ianniello 1 , S. Esposito 1 , A.<br />
Filippelli, F. Rossi.<br />
Department of Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology “L. Donatelli” and 1<br />
Department of Infectious Disease, Second University of Naples<br />
ENHANCEMENT OF IN VITRO MOXIFLOXACIN ANTIBACTERIAL ACTIVITY<br />
BY HUMAN ASCITIC FLUID<br />
1 Miglioli PA, 2 Cappellari G, 2 Cavallaro A, 2 Cardaioli C, 2 Sossai P, 3 Allerberger F, 3<br />
Fille M.<br />
1 2<br />
Dept. of Pharmacology and Anaesthesiology, University of Padua. Italy. Operative<br />
Unit of Internal Me<strong>di</strong>c<strong>in</strong>e, Civil Hospital of Feltre. Italy. 3 Institute of Hygiene,<br />
University of Innsbruck. Austria<br />
EVALUATION OF ANTIBIOTIC PROPHYLAXIS UTILITY IN CATARACT<br />
OPERATION<br />
Pann<strong>in</strong>i S., Runci FM., Giorgi G.<br />
Dipartimento <strong>di</strong> Farmacologia “G. Segre”. <strong>Università</strong> <strong>di</strong> Siena<br />
INTERACTON OF SAQUINAVIR WITH SOME ANTIMYCOTIC DRUGS ON<br />
STRAINS OF CANDIDAE AND CRYPTOCOCCI<br />
Zandomeneghi G 1 ., Baggio G 1 ., Casolari C 2 ., Ruberto I.A 1 ., Mumolo S 1 ., Zanca<br />
A 3 ,. Rossi T 4 ., Castelli M 1 .<br />
1 Section of Pharmacology, Dept. of Biome<strong>di</strong>cal Sci. and<br />
86<br />
2 Dept. of Hygiene,<br />
Microbiology and Biostatistics University of Modena and Reggio Emilia, via Campi<br />
287 -Modena, 3 ”C. Poma Hospital, Mantova, Italy, 4 Dept. of Pharmaceutical Sci.,<br />
University of Modena and Reggio Emilia,Modena Italy<br />
LEVOFLOXACIN DISPOSITION IN CEREBROSPINAL FLUID OF PATIENTS<br />
WITH EXTERNAL VENTRICULOSTOMY<br />
Pea F, 1 Pavan F, 1 Nascimben E, 2 Benetton C, 2 Scotton PG, 3 Vaglia A, 3 Furlanut M<br />
1<br />
1 Institute of Cl<strong>in</strong>ical Pharmacology & Toxicology, Department of Experimental and<br />
Cl<strong>in</strong>ical Pathology and Me<strong>di</strong>c<strong>in</strong>e, Me<strong>di</strong>cal School, University of Ud<strong>in</strong>e, Italy, 2<br />
Department of Anaesthesia and ICU, Regional Hospital Ca’ Foncello, Treviso, Italy 3<br />
Department of Infectious Diseases, Regional Hospital Ca’ Foncello, Treviso, Italy<br />
Abs. book<br />
page<br />
58<br />
89<br />
93<br />
103<br />
146<br />
105
Poster<br />
n°<br />
256.<br />
URINARY PHARMACOKINETICS AND THEORETICAL<br />
PHARMACODYNAMICS OF LEVOFLOXACIN IN ICU PATIENTS TREATED<br />
WITH 500 mg BID IV BECAUSE OF A VENTILATOR ASSOCIATED<br />
PNEUMONIA<br />
Pea F, 1 Pavan F, 1 Di Qual E, 1 Brollo L, 1 Nascimben E, 2 Baldassarre M, 3 Furlanut<br />
M 1<br />
1 Institute of Cl<strong>in</strong>ical Pharmacology & Toxicology, Department of Experimental and<br />
Cl<strong>in</strong>ical Pathology and Me<strong>di</strong>c<strong>in</strong>e, University of Ud<strong>in</strong>e, Italy 2 Department of<br />
Anaesthesia and ICU, Ca’ Foncello Regional Hospital, Treviso, Italy 3 1 st Department of<br />
Anaesthesia and ICU, SM Misericor<strong>di</strong>a Regional Hospital, Ud<strong>in</strong>e, Italy<br />
87<br />
Abs. book<br />
page<br />
105
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 2C<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Chemioterapia ant<strong>in</strong>eoplastica.<br />
POSTER 257-278<br />
Moderatore: G. Decorti (Trieste).<br />
Poster<br />
n°<br />
257.<br />
258.<br />
259.<br />
260.<br />
261.<br />
ANTI-INVASIVE EFFECT OF SOMATOSTATIN IN HUMAN TUMORAL CELL<br />
LINES<br />
Cattaneo M.G., Pola S., Vicent<strong>in</strong>i L.M.<br />
Dept of Pharmacology, University of Milano, Via Vanvitelli, 32 – 20129 Milano<br />
CYTOTOXIC EFFECTS OF LIPOSOMES ENCAPSULATED GEMCITABINE IN<br />
HUMAN THYROID CARCINOMA CELLS IN CULTURE<br />
Celano M., Calvagno M.G., Bulotta S., Rotiroti D., Fresta M., Russo D.<br />
Department of Pharmacobiological Sciences, Faculty of Pharmacy, University of<br />
Catanzaro “Magna Græcia”<br />
CYTOTOXICITY OF SOLID LIPID NANOPARTICLES INCORPORATING<br />
BUTYRIC ACID AND DOXORUBICIN ON A HUMAN COLORECTAL CANCER<br />
CELL LINE<br />
Serpe L 1 , Catalano MG 2 , Cavalli R 3 , Ugazio E 3 , Muntoni E 1 , Canaparo R 1 , Frairia<br />
R 2 , Gasco MR 3 , Zara GP 1 , Ean<strong>di</strong> M 1<br />
1 2<br />
Department of Anatomy, Pharmacology, and Forensic Me<strong>di</strong>c<strong>in</strong>e, Department of<br />
Cl<strong>in</strong>ical Phisiopathology and 3 Department of Pharmaceutical Science and Technology,<br />
University of Tur<strong>in</strong>, Italy.<br />
EFFECTS OF THE RUTHENIUM COMPOUND NAMI-A IN COMPARISON TO<br />
CIS-PLATIN AND DOXORUBICIN ON CELL MARKERS INVOLVED IN<br />
METASTATIC SPREADING IN B16 MURINE MELANOMA LINES<br />
Gava B. 1 , Zorzet S. 1 1 , 2<br />
, Sava G.<br />
1 2<br />
Department of Biome<strong>di</strong>cal science, University of Trieste; Fondazione Callerio-<br />
Onlus, Trieste; Italy<br />
EXPRESSION OF CORTISTATIN, A NATURAL SOMATOSTATIN-LIKE<br />
NEUROPEPTIDE, IN NORMAL AND NEOPLASTIC HUMAN TISSUES<br />
1 Muccioli G., 1 Tarabra E., 2 Allia E., 2 Papotti M.<br />
Departments: 1 Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, Division of Me<strong>di</strong>cal<br />
Pharmacology, and 2 Biome<strong>di</strong>cal Sciences and Oncology, Division of Pathology,<br />
Universiy of Tur<strong>in</strong>, Tur<strong>in</strong>, Italy<br />
88<br />
Abs. book<br />
page<br />
29<br />
30<br />
128<br />
65<br />
97
Poster<br />
n°<br />
262.<br />
263.<br />
264.<br />
265.<br />
266.<br />
267.<br />
268.<br />
FUNCTION AND FATE OF INSULIN LIKE GROWTH FACTOR - I RECEPTOR<br />
(IGF-IR) IN NORMAL AND TUMORAL LUNG TISSUE<br />
Carelli S., Paratore S., Bosari S. 1 , Di Giulio AM. , Gorio A.<br />
Laboratory of Pharmacology, 1 Section of Anatomical Pathology , Dept. of Medec<strong>in</strong>e,<br />
Surgery and Dentistry, University of Milano, Polo H. San Paolo, Via Di Rud<strong>in</strong>i 8,<br />
20142 Milano<br />
G2/M PREMITOTIC PHASE ARREST AND EXPRESSION OF CELL CYCLE<br />
REGULATORS PROTEINS ON KB CELLS TREATED WITH NAMI-A.<br />
R. Delf<strong>in</strong>o 1 , A. Bergamo 1 , C. Casarsa 1 1 , 2<br />
, G. Sava<br />
1 2<br />
Callerio Foundation ONLUS, Department of Biome<strong>di</strong>cal Sciences, University of<br />
Trieste, Italy<br />
IN VITRO ANTIPROLIFERATIVE EFFECTS OF MK-886 AND ROFECOXIB ON<br />
COLON CANCER CELL GROWTH<br />
1 Fulceri F, 1 Lazzeri G, 2 Danesi R, 1 Paparelli A, 2 Del Tacca M<br />
1 Department of Human Morphology and Applied Biology; 2 Division of Pharmacology<br />
and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies<br />
<strong>in</strong> Me<strong>di</strong>c<strong>in</strong>e, University of Pisa, Italy<br />
IN VITRO BIOLOGICAL ACTIVITY OF NEW ANALOGUES OF XANTHEN-9-<br />
ONE-4-ACETIC ACID<br />
Carrara M., Zampiron A., Caputo A., Gobbi S., Belluti F., Bisi A., Piazzi L., Rampa<br />
A., Valenti P.<br />
Department of Pharmacology & Anaesthesiology, Padova University, L.go E.<br />
Meneghetti, 2 Padova, and Department of Pharmaceutical Sciences, Bologna<br />
University, Via Belmeloro, 6 –Bologna, Italy<br />
INFLUENCE OF g-HYDROXYBUTYRIC ACID ON GROWTH AND<br />
DISSEMINATION OF LEWIS LUNG CARCINOMA IN MICE<br />
Genedani S., Bertol<strong>in</strong>i A. 1 , Ottani A., Filaferro M., Salt<strong>in</strong>i S.<br />
Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, Via Campi, 287 and 1<br />
Department of Internal Me<strong>di</strong>c<strong>in</strong>e, Section of Cl<strong>in</strong>ical Pharmacology and Toxicology,<br />
Via del Pozzo, 71; University of Modena and Reggio Emilia, Modena, Italy<br />
INVOLVEMENT OF MURINE CYTOCHROME P450 3A ENZYMES IN THE<br />
BIOACTIVATION<br />
(NEMORUBICIN)<br />
OF METHOXYMORPHOLINYL DOXORUBICIN<br />
Fant<strong>in</strong> M. 1 , Qu<strong>in</strong>tieri, L. 1 , Favero P. 1 , Geroni, C. 2 , Caruso M. 2 , Battaglia R. 2 ,<br />
Floreani M. 1<br />
1<br />
Dept. of Pharmacology and Anesthesiology, University of Padua, Italy;<br />
2<br />
Pharmacia<br />
Italy, Oncology, Nerviano (MI), Italy<br />
NOVEL OSMIUM-BASED CLUSTERS WITH ANTITELOMERASE ACTIVITY<br />
Ghiglia A. 1 , Colangelo D. 1 , Osella D. 2 , Rosenberg E. 3 , Ravera M. 2 , Crisp<strong>in</strong>o L. 4 ,<br />
Viano I. 1<br />
1 Dip. Scienze Me<strong>di</strong>che, Facoltà Me<strong>di</strong>c<strong>in</strong>a e Chirurgia, Univ. del Piemonte Orientale,<br />
Novara; 2 Dip. Scienze e Tecnologie Avanzate, <strong>Università</strong> del Piemonte Orientale,<br />
Alessandria; 3 Department of Chemistry, University of Montana, Missoula; 4 <strong>Università</strong><br />
“Federico II”, Napoli<br />
89<br />
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page<br />
24<br />
43<br />
61<br />
26<br />
66<br />
54<br />
68
Poster<br />
n°<br />
269. PHARMACOLOGICAL ACTIVITIES OF RUTHENIUM COMPLEXES RELATED<br />
TO NITRIC OXIDE-SCAVENGER PROPERTY<br />
Castellar<strong>in</strong> A. 2 , Zorzet S. 1 , Mor<strong>in</strong>i M. 3 , Alb<strong>in</strong>i A. 3 1 , 2<br />
, Sava G<br />
1 2<br />
Department of Biome<strong>di</strong>cal Sciences, University of Trieste; Fondazione C. & D.<br />
Callerio ONLUS, Trieste; 3 Advanced Biotechnologies Centre (CBA), University of<br />
Genoa, Italy<br />
270.<br />
271.<br />
272.<br />
273.<br />
274.<br />
275.<br />
PHENOTYPE OF metGM CELLS INFLUENCES THE SENSIBILITY TO THE<br />
ANTIMETASTASIS AGENT NAMI-A: FROM REDUCTION OF INVASIVE<br />
POTENTIAL VIA CD44 DOWN-REGULATION TO CELL CYCLE ARREST<br />
Bacac M 1,2 , Pacor S 1 , Rosati A 1 , Sava G<br />
1 Department of Biome<strong>di</strong>cal Sciences, University of Trieste, via L. Giorgieri 7, 34127,<br />
Trieste, Italy; 2 Callerio Foundation Onlus, Italy<br />
PHOTODYNAMIC EFFECTS OF NEW PHOTOSENSITIZER AGENTS IN HUMAN<br />
COLON ADENOCARCINOMA CELL LINES<br />
Garibol<strong>di</strong> M.B., Ravizza R., Banfi S., Caruso E., 1 Canti G., Monti E.<br />
Dipartimento <strong>di</strong> Biologia Strutturale e Funzionale – <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> dell’Insubria,<br />
Busto Arsizio (Varese); 1 <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano<br />
ROLE OF THE NO/CA 2+ /MAP KINASE SIGNALLING PATHWAY IN THE<br />
REGULATION OF PROLIFERATION IN HUMAN ASTROCYTOMA U-373 MG<br />
CELLS<br />
Blanco Garcia J., Me<strong>in</strong>i A., Pess<strong>in</strong>a G.P., Ald<strong>in</strong>ucci C., Palmi C.<br />
Dipartimento <strong>di</strong> Anatomia e Scienze Biome<strong>di</strong>che, <strong>Università</strong> <strong>di</strong> Siena, Siena, Italy;<br />
Dipartimento <strong>di</strong> Fisiologia, Siena, Italy<br />
SHORT TERM EXPOSURE TO THE ANTIMETASTASIS RUTHENIUM<br />
COMPLEX NAMI-A MODIFYES CELL ADHESION AND INFLUENCE ACTIN<br />
POLIMERIZATION<br />
G. Sava 1 , 2 , F. Fraus<strong>in</strong> 1 , M. Cocchietto 2 , F. Vita 3 , E. Podda 3 , P. Spessotto 4 , A.<br />
Furlani 1 , V. Scarcia 1 , G. Zabucchi 3<br />
1 Department of Biome<strong>di</strong>cal Sciences and 3 Department of Physiology and Pathology,<br />
University of Trieste, Italy ; 2 Callerio Foundation Onlus, Trieste, Italy; Center of<br />
Oncological Reference, Aviano, Italy<br />
SOMATOSTATIN BLOCKADE OF TUMOR-DEPENDENT NEO-ANGIOGENESIS<br />
THROUGH SOMATOSTATIN RECEPTOR 3 INHIBITION OF NOS III AND MAP<br />
KINASE ACTIVITIES<br />
Arena S. 1 , Villa V. 1 , Mor<strong>in</strong>i M. 3 , Corsaro A. 1 , Thellung S. 1 , Noonan D. 3 , Alb<strong>in</strong>i A. 3<br />
, Schett<strong>in</strong>i G. 1 , 2 , Florio T.<br />
1 , 2<br />
1 Dept. Oncol., Biol. and Genetics, Univ. Genova, 2 Pharmacology and Neuroscience<br />
and 3 Molecular Biology, Natl. Inst. Cancer Research (IST) Genova Italy<br />
STROMAL CELL-DERIVED FACTOR-1a (SDF-1a) STIMULATES HUMAN<br />
GLIOBLASTOMA CELL GROWTH THROUGH THE ACTIVATION OF AN<br />
AUTOCRINE-PARACRINE PATHWAY<br />
1 , 2 1 , 2 1 , 2 1 1 , 2 2<br />
Bajetto A., Barbero S., Bonavia R., Pirani P., Porcile C., Castelnuovo<br />
M., 1 Florio T., 1 , 2 Schett<strong>in</strong>i G.<br />
1<br />
Pharmacology and Neuroscience, Institute for Cancer Research c/o Advanced<br />
Biotechnology center, Genoa, Italy; 2 Pharmacology, Dep.of Oncology, Biology and<br />
Genetics, University of Genoa, Italy<br />
90<br />
1 , 2<br />
Abs. book<br />
page<br />
27<br />
5<br />
65<br />
13<br />
126<br />
4<br />
6
Poster<br />
n°<br />
276.<br />
277.<br />
278.<br />
STROMAL CELL-DERIVED FACTOR-1a (SDF-1a) STIMULATES OVARIAN<br />
CANCER CELL GROWTH THROUGH THE ACTIVATION OF ERK1/2<br />
PATHWAY AND EGF RECEPTORS<br />
1 , 2 Porcile C., 1 , 2 Bonavia R., 1 , 2 Barbero S., 1 Pirani P., 1 , 2 Bajetto A., 1 , 2<br />
Schett<strong>in</strong>i G.<br />
1 Pharmacology and Neuroscience, Institute for Cancer Research c/o Advanced<br />
Biotechnology center, Genoa, Italy; 2 Pharmacology, Dep.of Oncology, Biology and<br />
Genetics, University of Genoa, Italy<br />
THE ASPIRIN METABOLITE SALICYLATE INHIBITS DNA ADDUCTS<br />
FORMATION IN PRIMARY CULTURES OF 7,12-<br />
DIMETHYLBENZANTHRACENE INDUCED RAT MAMMARY TUMORS<br />
Abbadessa G., Di Carlo F., Dacasto M 1 ., Nebbia C 1 ., Carletti M. 1 , Sartori M.L.,<br />
Spaccamiglio A., Racca S.<br />
Dipartimento <strong>di</strong> Scienze Cl<strong>in</strong>iche e Biologiche and 1 Dipartimento <strong>di</strong> Patologia<br />
Animale, <strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o<br />
THE PROTEASOME INHIBITOR MG132 INDUCES APOPTOSIS IN HUMAN<br />
HEPATOCELLULAR CARCINOMA CELLS: INVOLVEMENT OF CASPASE-<br />
DEPENDENT CLEAVAGE OF BETA-CATENIN<br />
Notarbartolo M, D’ Alessandro N, Labbozzetta M 2 , Poma P, Giannitrapani L 2 ,<br />
Montalto G 2 , Cervello M 1<br />
Dipartimenti <strong>di</strong> Scienze Farmacologiche e 2 <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Cl<strong>in</strong>ica e delle Patologie<br />
Emergenti, <strong>Università</strong> <strong>di</strong> Palermo. 1 IBIM “A. Monroy”, CNR, Palermo<br />
91<br />
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page<br />
113<br />
1<br />
99
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 2C<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia delle tossico<strong>di</strong>pendenze.<br />
POSTER 279-298<br />
Moderatore: P. Nenc<strong>in</strong>i (Roma).<br />
Poster<br />
n°<br />
279.<br />
280.<br />
281.<br />
282.<br />
283.<br />
ADMINISTRATION OF A CANNABINOID AGONIST REDUCES IMPULSIVE<br />
BEHAVIOR IN AN ANIMAL MODEL OF ADHD.<br />
Adriani W 1 ; Caprioli A 2 ; Laviola G 1<br />
1 Behavioral Pathophysiology, Lab Fisiopatologia OS, Istituto Superiore <strong>di</strong> Sanità,<br />
Roma; 2 Behavioral Pharmacology Lab, “Sigma-Tau” SpA, Pomezia<br />
ALPHA-1B ADRENERGIC RECEPTOR KNOCKOUT MICE ARE PROTECTED<br />
AGAINST METHAMPHETAMINE TOXICITY<br />
Carla L. Busceti 1 , Giuseppe Battaglia 1 , Francesco Fornai 1,2 , Giuseppe Lembo 1,3 ,<br />
Antonio De Blasi 1 , Ferd<strong>in</strong>ando Nicoletti 1,4<br />
1 I.R.C.C.S. Istituto Neurologico Me<strong>di</strong>terraneo Neuromed, Pozzilli, Italy; 2 Department<br />
of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy;<br />
3 Department of Experimental Me<strong>di</strong>c<strong>in</strong>e and Pathology, University “La Sapienza”,<br />
Roma, Italy; 4 Department of Human Physiology and Pharmacology, University “La<br />
Sapienza”, Roma, Italy<br />
BEHAVIORAL EFFECTS OF ETHANOL AT LOW DOSES: THE INVOLVEMENT<br />
OF DOPAMINE D2 RECEPTORS<br />
Castor<strong>in</strong>a M. and Drago F.<br />
Department of Experimental and Cl<strong>in</strong>ical Pharmacology; University of Catania Me<strong>di</strong>cal<br />
School, Viale A. Doria 6, 95125 Catania, Italy<br />
CAFFEINE SUBCHRONIC TREATMENT MODIFIES ZIF-268 MRNA<br />
EXPRESSION BY AMPHETAMINE IN THE RAT STRIATUM<br />
Tronci E., Pala P., Carta A.R., Cauli O., P<strong>in</strong>na A., Morelli M.<br />
Dept. Toxicology, Univ. Cagliari, Italy<br />
CANNABINOIDS MODULATE THE IMMUNOLOGICAL ACTIVATION OF<br />
GUINEA PIG MAST CELLS AND HUMAN BASOPHILS. THE ROLE OF NITRIC<br />
OXIDE AND EICOSANOIDS<br />
Giann<strong>in</strong>i L., Vannacci A., Di Felice A, Pierpaoli S, Zagli G, Fantappiè O., Mannaioni<br />
P.F., Mas<strong>in</strong>i E.<br />
Department of Precl<strong>in</strong>ical and Cl<strong>in</strong>ical Pharmacology, Me<strong>di</strong>cal Toxicology Unit, Viale<br />
Pieracc<strong>in</strong>i, 6, 50139 Firenze<br />
92<br />
Abs. book<br />
page<br />
2<br />
18<br />
28<br />
140<br />
68
Poster<br />
n°<br />
284.<br />
285.<br />
286.<br />
287.<br />
288.<br />
289.<br />
290.<br />
DIFFERENTIAL CHANGES IN GABA-A RECEPTOR GENE EXPRESSION AND<br />
FUNCTION INDUCED BY CHRONIC ETHANOL TREATMENT AND ETHANOL<br />
WITHDRAWAL IN CULTURED RAT HIPPOCAMPAL NEURONS<br />
Talani G.; Busonero F.; Mostall<strong>in</strong>o M.C.; Follesa P.; Spiga S. 1 ; Serra G.P. 1 ;Sanna E.<br />
Dept. of Experimental Biology, Section of Neuroscience and Centro <strong>di</strong> Eccellenza per<br />
la “Neurobiologia delle Tossico<strong>di</strong>pendenze”, 1 Dept. of Animal Biology and Ecology,<br />
University of Cagliari, Cagliari<br />
EFFECTS OF CANNABINOIDS ON NON-ADRENERGIC NON-CHOLINERGIC-<br />
MEDIATED RELAXATION IN GUINEA-PIG TRACHEA<br />
Mart<strong>in</strong>elli C., Breschi M.C., Mart<strong>in</strong>otti E., Nieri P.<br />
Dipartimento <strong>di</strong> Psichiatria, Neurobiologia, Farmacologia e Biotecnologie; Facoltà <strong>di</strong><br />
Farmacia, via Bonanno 6, 56126 Pisa<br />
ETHANOL CONSUMPTION DIFFERENTIALLY AFFECTS MONOAMINERGIC<br />
RESPONSE IN THE NACS AND MPFC OF SARDINIAN-PREFERRING AND<br />
WISTAR RATS<br />
Leggio B. 1 , Grappi S. 1 , Gambarana C. 1 , De Montis M.G 2<br />
1 Department of Neuroscienze, <strong>Università</strong> <strong>di</strong> Siena, Via Aldo Moro, 4, 53100 Siena,<br />
Italy 2 Department of Scienze del Farmaco, University of Sassari, Italy<br />
HIPPOCAMPAL N/OFQ AND NOP RECEPTOR ALTERATIONS INDUCED BY<br />
MORPHINE TOLERANCE<br />
Landuzzi D., D’Addario C., Di Benedetto M., Cevolani A. Romual<strong>di</strong> P., Candeletti S.<br />
Dept. of Pharmacology, University of Bologna, Italy<br />
LEPTIN DOES NOT MODIFY ETHANOL INTAKE IN MARCHIGIAN<br />
SARDINIAN ALCOHOL-PREFERRING RATS<br />
Polidori Carlo, Luciani Fabio, Fedeli Amalia, Geary Nori 1 , Massi Maurizio.<br />
Department of Pharmacological Science and Experimental Me<strong>di</strong>c<strong>in</strong>e, University of<br />
Camer<strong>in</strong>o, MC, Italy and 1 E.W. Bourne Behavioral Research Laboratory, Department<br />
of Psychiatry, Weill Me<strong>di</strong>cal College of Cornell University and New York Presbyterian<br />
Hospital, White Pla<strong>in</strong>s, NY 10605 USA<br />
LONG-TERM EFFECTS OF MATERNAL EXPOSURE TO CARBON MONOXIDE<br />
AND WIN 55,212-2: COGNITIVE ALTERATIONS IN RAT<br />
Giust<strong>in</strong>o A. 1 , Tattoli M. 1 , Cagiano R. 1 , Coluccia A. 1 , CuomoV 2 .<br />
1 Department of Pharmacology and Human Physiology, University of Bari, Italy; 2<br />
Department of Pharmacology and General Physiology, University of Rome ”La<br />
Sapienza”, Italy<br />
NICOTINE ADDICTION THERAPY: EFFECTS, ADVANTAGES AND<br />
DISADVANTAGES<br />
Picciolo M., Gigante D., Nunziata A.<br />
Research, Health Department, ETI SpA<br />
93<br />
Abs. book<br />
page<br />
135<br />
85<br />
77<br />
76<br />
111<br />
70<br />
108
Poster<br />
n°<br />
291.<br />
292.<br />
293.<br />
294.<br />
295.<br />
296.<br />
297.<br />
298.<br />
PROTECTIVE EFFECT OF CANNABINOIDS ON CHOLERA TOXIN-INDUCED<br />
INTESTINAL FLUID ACCUMULATION IN MICE<br />
1 Capasso R., 1 Izzo A.A., 1 Capasso F., 2 Bisogno T., 3 Marsicano G, 2 Ligresti A., 3<br />
Lutz B., 2 Di Marzo V., 1 Mascolo N.<br />
1 Department of Experimental Pharmacology, University of Naples “Federico II”,<br />
Naples, Italy; 2 Endocannab<strong>in</strong>oid Research Group, CNR Pozzuoli (NA), Italy; 3<br />
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Munich<br />
(Germany)<br />
SEROTONINERGIC SYSTEM MAY MEDIATE BENEFICIAL EFFECTS OF<br />
HYPERICUM PERFORATUM ON NICOTINE ABSTINENCE SIGNS IN MICE<br />
Catania M.A. 1 , Mannucci C. 1 , Crupi A. 2 , Firenzuoli F. 3 , Calapai G. 1<br />
1 Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology, School of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Mess<strong>in</strong>a, Italy; 2 Pharmalife Research Italia, Calolziocorte (LC)<br />
Italy. 3 Service of Phytotherapy, ASL 11 Empoli, Italy<br />
SOCIAL ISOLATION-INDUCED INCREASE IN THE SENSITIVITY OF RATS TO<br />
THE STEROIDOGENIC EFFECT OF ETHANOL<br />
Pisu M.G. 1 , Floris I., Floris S., Serra M.<br />
Department of Experimental Biology, University of Cagliari, Cagliari, Italy; 1 C.N.R.<br />
Institute of Neuroscience, Pisa, Italy<br />
SYNTHETIC CANNABINOID WIN 55,212-2 AND AM 404 REDUCE PLASMA<br />
EXTRAVASATION IN A RAT MODEL OF NEUROPATHIC PAIN<br />
Russo R., La Rana G., Calignano A.<br />
Dept. of Experimental Pharmacology, Faculty of Pharmacy, via D. Montesano 49<br />
Naples, Italy<br />
SYNTHETIC CANNABINOIDS WIN 55,212-2 AND AM 404, AN IHIBITOR OF<br />
ANANDAMIDE REUPTAKE, ATTENUATE MECHANICAL AND THERMAL<br />
HYPERALGESIA IN A MODEL OF NEUROPATHIC PAIN<br />
La Rana G., Russo R., Calignano A.<br />
Dept. of Experimental Pharmacology, Faculty of Pharmacy, via D. Montesano 49<br />
Naples, Italy<br />
THE BINDING OF [ 3 H]CP 55,940 TO CANNABINOID CB1 RECEPTORS IN THE<br />
BOVINE RETINA<br />
Lograno M.D., Romano M.R.<br />
Department of pharmacobiology, University of Bari, Via E. Orabona, 4, 70125 Bari,<br />
Italy<br />
THE ROLE OF MUSCARINIC RECEPTORS IN THE CONTROL OF ACUTE<br />
MORPHINE WITHDRAWAL<br />
Sabat<strong>in</strong>o C., Milano W., Petrella C., Capasso A.<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Salerno, Via Ponte Don Melillo<br />
(84084) Fisciano, Salerno<br />
THE ROLE OF SEROTONIN IN THE DEVELOPMENT OF MORPHINE<br />
WITHDRAWAL<br />
Far<strong>in</strong>a R., Sabat<strong>in</strong>o C., Milano W., Petrella C., Capasso A.<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Salerno<br />
94<br />
Abs. book<br />
page<br />
23<br />
29<br />
110<br />
122<br />
76<br />
79<br />
123<br />
54
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia dei recettori e dei meccanismi <strong>di</strong> trasduzione del segnale.<br />
POSTER 299-314<br />
Moderatore: G. Fumagalli (Verona).<br />
Poster<br />
n°<br />
299.<br />
300.<br />
301.<br />
302.<br />
2-AMINOBENZENSULFONAMIDES: A NEW CLASS OF GLUTAMATE<br />
IONOTROPIC RECEPTORS MODULATORS<br />
Gabriele Losi 1 , Giuseppe Cannazza 1 , Daniela Braghiroli , Carlo Parenti 1 , Mario<br />
Baral<strong>di</strong> 1 , Giulia Puia 1<br />
1 Dip.to Scienze Farmaceutiche, <strong>Università</strong> <strong>di</strong> Modena e Reggio Emilia, Via Campi<br />
183, 41100 Modena, Italy and 2 Universita` <strong>degli</strong> <strong>Stu<strong>di</strong></strong> “G. D’Annunzio” Chieti, Via<br />
dei Vest<strong>in</strong>i, 66013 Chieti, Italy<br />
ABERRANT AMPLIFICATION OF A2A ADENOSINE RECEPTOR SIGNALLING<br />
IN THE BRAINS OF HUNTINGTON'S DISEASE TRANSGENIC MICE<br />
Tar<strong>di</strong>ti A., Camurri A.,Rigamonti D., Cattaneo E. 1 and Abbracchio M.P. 1<br />
1 these authors equally contributed to this paper<br />
Department of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy<br />
ALTERED INTRACELLULAR INSULIN-MEDIATED SIGNALLING IN<br />
LYMPHOCYTES FROM SUBJECTS WITH ALZHEIMER’S DISEASE<br />
Castri P 1 , Iula M. 2 , Melchiorri D. 2 , Nicoletti F. 2 ,3 , Orzi F. 1 , Giubilei F. 1 , Iacovelli<br />
L.<br />
2 ,3<br />
1 Istituto <strong>di</strong> Scienze Neurologiche, II Facoltà, <strong>Università</strong> “La Sapienza” <strong>di</strong> Roma<br />
2 Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia <strong>Università</strong> “La Sapienza” <strong>di</strong> Roma,<br />
3 INM Neuromed, Pozzilli<br />
BACE1 REGULATES THE FORMATION OF APP’S FRAGMENTS THAT<br />
INTERACT WITH THE INTRACELLULAR ADAPTOR SHCA AND GRB2<br />
Repetto E., Venezia V., Salis S., Dolc<strong>in</strong>i V., Genova F., Nizzari M., Russo C.,<br />
Schett<strong>in</strong>i G.<br />
Pharmacology and Neuroscience National Cancer Institute (IST) c/o Advanced<br />
Biotechnology Center and Section of Pharmacology Deptartment of Oncology, Biology<br />
and Genetics University. of Genova, Italy<br />
95<br />
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page<br />
80<br />
136<br />
28<br />
117
Poster<br />
n°<br />
303.<br />
304.<br />
305.<br />
306.<br />
307.<br />
308.<br />
CHANGES IN GABAA RECEPTOR GENE EXPRESSION INDUCED BY<br />
WITHDRAWAL OF, BUT NOT BY LONG-TERM EXPOSURE TO,<br />
GANAXOLONE IN CULTURED RAT CEREBELLAR GRANULE CELLS<br />
Mancuso L., Biggio F., Gor<strong>in</strong>i G., Cabras S., Orrù A., Caria S., Marra C., 1 Mascia<br />
M.P., Follesa P.<br />
Department of Experimental Biology, Neuroscience Section, University of Cagliari,<br />
Cagliari, Italy, 1 CNR Institute of Neuroscience, Section of Neuropsychopharmacology,<br />
Cagliari, Italy<br />
CHARACTERIZATION OF THE EFFECTS OF A SERIES OF ARYL<br />
SUBSTITUTED IMIDAZOLES, A NOVEL CLASS OF POTENT AND<br />
EFFICACIOUS ALLOSTERIC MODULATORS OF GABA-A RECEPTOR<br />
FUNCTION<br />
Busonero F., Talani G., Tranquilli S., Mascia M.P., Mostall<strong>in</strong>o M.C., Macciocco E.,<br />
Asproni B. 1 , Cerri R. 1 , Pau A. 1 , Sanna E.<br />
Dip. <strong>di</strong> Biologia Sperimentale, Sezione <strong>di</strong> Neuroscienze e Centro <strong>di</strong> Eccellenza per la<br />
“Neurobiologia delle Tossico<strong>di</strong>pendenze”, <strong>Università</strong> <strong>di</strong> Cagliari, Cagliari, 1 Dip.<br />
Farmaco Chimico Tossicologico, Facoltà <strong>di</strong> Farmacia, <strong>Università</strong> <strong>di</strong> Sassari, Sassari<br />
CHRONIC PROGESTERONE AND DIAZEPAM, LIKE ETHANOL, CHANGES<br />
THE GENE EXPRESSION AND FUNCTION OF GABAA RECEPTOR IN RAT<br />
CEREBELLAR GRANULE CELLS IN CULTURE<br />
Biggio F., Mancuso L., Gor<strong>in</strong>i G., Cabras S., Orrù A., Caria S., Sanna E., Follesa P.<br />
Department of Experimental Biology, Neuroscience Section, University of Cagliari,<br />
Cagliari, Italy<br />
CysLT1 RECEPTOR ACTIVATES THE SMALL GTP-BINDING PROTEIN Ras IN<br />
U937 CELLS<br />
Rovati G.E., Ravasi S., Accomazzo, M.R., 1 Parenti M., Capra V.<br />
Laboratory of Molecular Pharmacology, Dept. of Pharmacological Sciences, University<br />
of Milan, Via Balzaretti 9, 20133 Milan, Italy, 1 Dept. of Experimental and<br />
Environmental Me<strong>di</strong>c<strong>in</strong>e and Me<strong>di</strong>cal Biotechnologies, University of Milan Bicocca<br />
ETHANOL EVOKES INFLAMMATORY RESPONSES IN DURA MATER AND<br />
TRIGEMINAL GANGLIA OF THE GUINEA PIG: RELEVANCE FOR MIGRAINE<br />
1 Trevisani, M., 1 Manconi, M., 1 Harrison, S. 2 Nicoletti P., 2 Geppetti, P.<br />
1 Inter<strong>di</strong>scipl<strong>in</strong>ary Centre of Excellence for the Study of Inflammation (ICSI),<br />
University of Ferrara, Ferrara, Italy; 2 Department of Critical Care Me<strong>di</strong>c<strong>in</strong>e and<br />
Surgery, University of Florence, Florence, Italy<br />
EXPRESSION OF MGLU RECEPTOR SUBTYPES DURING PRE - AND<br />
POSTNATAL LIFE<br />
Cirica A. 1 , DiGiorgi Gerev<strong>in</strong>i V. 1 , Caruso A. 1 , Cappuccio I. 1 , Melchiorri D. 1 ,<br />
1 , 2<br />
Nicoletti F.<br />
1 2<br />
Dept. of human Physiology and Pharmacology, University of Rome " La Sapienza",<br />
I.N.M: Neuromed, Pozzilli, Italy<br />
96<br />
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page<br />
82<br />
18<br />
12<br />
120<br />
139<br />
34
Poster<br />
n°<br />
309.<br />
310.<br />
311.<br />
312.<br />
313.<br />
314.<br />
METABOTROPIC GLUTAMATE RECEPTOR 5 (MGLUR5)-MEDIATED EFFECTS<br />
ARE BLUNTED IN THE STRIATUM OF AGED RATS: A POSSIBLE<br />
ADDITIONAL MECHANISM IN STRIATAL SENESCENCE<br />
Domenici M.R. 1 , P<strong>in</strong>tor A. 1 , Potenza R.L. 1 , Grò M.C. 1 , Gau<strong>di</strong>, S. 1 , Passarelli F. 2 ,<br />
Popoli P. 1<br />
1 Department of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Viale Reg<strong>in</strong>a Elena, 299<br />
00161 Rome (Italy). 2 Department of Neurological Sciences, University “La Sapienza”,<br />
Rome (Italy)<br />
METABOTROPIC GLUTAMATE RECEPTORS REGULATE PROLIFERATION<br />
AND SURVIVAL OF CULTURED NEURAL STEM CELLS<br />
1 DiGiorgi Gerev<strong>in</strong>i V, 1 Cirica A., Calò L. 1 , Ricci Vitiani L. 3 , Pagano S. 4 , De Maria<br />
R. 3 , Parati E. 4 , 1,2 Nicoletti F., 1,2 Melchiorri D.<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”; 2 I.N.M. Neuromed, Pozzilli; 3 Laboratory of Hematology and Oncology,<br />
Istituto Superiore <strong>di</strong> Sanità, Rome; 4 Istituto Neurologico C. Besta, Milan<br />
NEUROTENSIN (NT) ENHANCES ENDOGENOUS EXTRACELLULAR<br />
GLUTAMATE LEVELS IN PRIMARY CULTURES OF RAT CORTICAL<br />
NEURONS: INVOLVEMENT OF NT IN GLUTAMATE-INDUCED<br />
EXCITOTOXICITY<br />
Tomas<strong>in</strong>i M.C., Ferraro L., Fuxe K. 2 , F<strong>in</strong>etti S. 1 , Fournier J. 3 , Tanganelli S. 1 , De<br />
Mattei M. 4 , Antonelli T. 1<br />
1 Dep. Cl<strong>in</strong>. Exp. Me<strong>di</strong>c<strong>in</strong>e, Univ. of Ferrara, Italy;<br />
97<br />
2 Dep. Neuroscience, Karol<strong>in</strong>ska<br />
Inst., Stockholm, Sweden; 3 Sanofi-Synthelabo Recherche, Montpellier, France. 4 Dep.<br />
Human Anat. Physiol. Univ. of Ferrara, Italy<br />
ROSIGLITAZONE AND 15-DEOXY-D 1 2 , 1 4 -PROSTAGLANDIN J2, LIGANDS OF<br />
THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-g (PPAR-g),<br />
REDUCE ISCHEMIA/REPERFUSION INJURY OF THE GUT<br />
1 2 2 1 1<br />
Dugo L, Pisano B, Ianaro A, Patel NSA , DiPaola R, Genovese T, Chatterjee<br />
PK, 2 Di Rosa M, 1 Caputi AP, 3 Thiemermann C, 1 Cuzzocrea S<br />
1 2<br />
Dept. of Pharmacology, University of Mess<strong>in</strong>a, Italy. Dept. of Pharmacology,<br />
University of Naples, Italy. 3 William Harvey Research Institute, St. Bart’s and Queen<br />
Mary University of London, UK<br />
THE 5HT2A RECEPTOR AGONIST DOI ATTENUATES THE GLUTAMATE<br />
NEUROTOXICITY IN PRIMARY CORTICAL CELL CULTURES<br />
Voltattorni M., Dall’ Olio R., Gandolfi O.<br />
Dept. of Pharmacology, University of Bologna<br />
THE ADENOSINE A2A RECEPTOR ANTAGONIST ZM 241385<br />
DIFFERENTIALLY INFLUENCES EXCITOTOXIC MECHANISMS AT PRE AND<br />
POST-SYNAPTIC SITE IN THE RAT STRIATUM<br />
Tebano MT, P<strong>in</strong>tor A, Frank C, Domenici MR, Pepponi R., Potenza RL, Martire A,<br />
Grieco R, Nazzicone V, Popoli P<br />
Pharmacology Department, Istituto Superiore <strong>di</strong> Sanità, Viale Reg<strong>in</strong>a Elena, 299 Rome,<br />
Italy<br />
Abs. book<br />
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52<br />
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SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Controllo farmacologico della morte cellulare e dei processi degenerativi.<br />
POSTER 315-336<br />
Moderatore: S. Ceruti (Milano).<br />
Poster<br />
n°<br />
315.<br />
316.<br />
317.<br />
318.<br />
ACTIVATION OF CD95/FAS RECEPTOR MEDIATES THE INCREASE IN GD3<br />
FORMATION IN CULTURED CEREBELLAR GRANULE CELL COMMITTED TO<br />
APOPTOTIC DEATH<br />
1, 2 Grad<strong>in</strong>i R., 3 Castiglione M., 3 Sp<strong>in</strong>santi P., 2,3 Iacovelli L., 1 Lenti L., 1 Mart<strong>in</strong>i F.,<br />
3 DiGiorgi Gerev<strong>in</strong>i V. , 3 Caricasole A., 3 Caruso A., 4 De Maria R., 2,3 Nicoletti F., 3<br />
Melchiorri D.<br />
Departments of 3 Human Physiology and Pharmacology, and 1 Experimental Me<strong>di</strong>c<strong>in</strong>e<br />
and Pathology, University of Rome “La Sapienza”; 2 I.N.M. Neuromed, Pozzilli; 4<br />
Laboratory of Hematology and Oncology, Istituto Superiore <strong>di</strong> Sanità, Rome, Italy<br />
ALTERATION OF ASTROCYTE CALCIUM-DEPENDENT GLUTAMATE<br />
RELEASE IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE<br />
Brambilla L. 1 , Rossi D. 1 , Valori C. 1 , Bezzi P. 1,4 , Giaccone G. 2 , Capobianco R. 2 ,<br />
Mangieri M. 2 , K<strong>in</strong>gston A. 3 , Volterra A.<br />
1 ,4<br />
1 Dep. of Pharmacol. Sciences, CEND, University of Milan, via Balzaretti, 9, 20133<br />
Milan, Italy; 2 National Neurological Institute “Carlo Besta”, via Celoria, 11, 20133<br />
Milan, Italy; 3 Lilly Research Center, Eli Lilly and Co. Ltd., W<strong>in</strong>dlesham, Surrey, UK<br />
and In<strong>di</strong>anapolis, USA.; 4 IBCM, University of Lausanne, rue du Bugnon, 9, 1005<br />
Lausanne, Switzerland<br />
APOPTOSIS OF SPINAL CORD ASTROCYTES SECONDARY TO ALS-LINKED<br />
SOD1 MUTATIONS<br />
Rossi D. 1 , Cafè C. 1 , Valori C. 1 , Yokota T. 2 , Bredesen D. 2 , Volterra A. 1<br />
1 Centre of Excellence on neurodegenerative <strong>di</strong>seases and Dept. of Pharmacological<br />
Sciences, University of Milan, via Balzaretti 9, 20133 Milan 2 Buck Institute, 8001<br />
Redwood Blvd, Novato, CA 94945<br />
APOPTOSIS VS NECROSIS: GLUTATHIONE MEDIATED CELL DEATH<br />
DURING REWARMING OF RAT HEPATOCYTES<br />
Vairetti M. 1 , Ferrigno A. 1 , Bertone R. 2 , Freitas I. 2 , Bertè F. 1 , Richelmi P. 1<br />
1 Department of Internal Me<strong>di</strong>c<strong>in</strong>e and Therapeutics, University of Pavia, 2 Department<br />
of Animal Biology and CNR Center for Histochemistry, University of Pavia<br />
98<br />
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71<br />
16<br />
120<br />
141
Poster<br />
n°<br />
319.<br />
320.<br />
321.<br />
322.<br />
323.<br />
324.<br />
CYCLOSPORINE-A TREATMENT COUNTERACTS WEAKNESS AND<br />
BIOPHYSICAL, HISTOLOGICAL AND BIOCHEMICAL ALTERATIONS<br />
INDUCED BY MUSCLE DEGENERATION IN DYSTROPHIC MDX MOUSE<br />
De Luca A., Liantonio A., Didonna M., Pierno S., Fraysse B., Camer<strong>in</strong>o C., Bur<strong>di</strong> R.,<br />
Cetrone M., Confalonieri P. 1 , Oliva L. 1 , Andreetta F. 1 , Conte Camer<strong>in</strong>o D.<br />
Unit of Pharmacology, Dept. of Pharmacobiology, University of Bari and 1 Dept. of<br />
Neuromuscular Diseases, National Neurological Insitute "C. Besta", Milan. Italy<br />
EXCESSIVE GLUTAMATE RELEASE INDUCED BY ACTIVATION OF<br />
GLYCINE AND GABA HETEROTRANSPORTERS IN A MOUSE MODEL OF<br />
AMYOTROPHIC LATERAL SCLEROSIS<br />
Raiteri L. 1 , Stigliani S. 1 , Zappett<strong>in</strong>i S. 1 , Mercuri N. 2 , Raiteri M. 1 ;3 , Bonanno G.<br />
1 Department of Experimental Me<strong>di</strong>c<strong>in</strong>e (DIMES)-Pharmacology and Toxicology<br />
section University of Genova; 2 Fondazione S. Lucia IRCCS , Roma, Italy and 3 Center<br />
of Excellence for Biome<strong>di</strong>cal Research (CEBR), University of Genova, Italy<br />
FATE OF AUTOLOGOUS DERMAL STEM CELLS TRANSPLANTED INTO THE<br />
SPINAL CORD AFTER TRAUMATIC INJURY (TSCI). EVALUATION OF THE<br />
RECOVERY FROM HINDLIMB DISABILITY<br />
Laura Madaschi 2 , Yvan Torrente 1 , Nereo Bresol<strong>in</strong> 1 , Anna Barbara Di Stefano 1 ,<br />
Anna Maria Di Giulio 1 , Alfredo Gorio 1<br />
2 Laboratory of Pharmacology, Department of Me<strong>di</strong>c<strong>in</strong>e, Surgery and Dentistry, Faculty<br />
of Me<strong>di</strong>c<strong>in</strong>e, University of Milan, Via A <strong>di</strong> Rud<strong>in</strong>ì 8, Milano 20142, Italy; 1 IRCCS<br />
Ospedale Maggiore Policl<strong>in</strong>ico, Department of Neurological Science, Centro D<strong>in</strong>o<br />
Ferrari, University of Milan, Via F. Sforza, Milano, Italy<br />
GLIA MEDIATES THE NEUROPROTECTIVE EFFECT OF ESTROGEN AGAINST<br />
AMPA-TOXICITY IN SPINAL MOTONEURON CULTURES: INVOLVEMENT OF<br />
CYTOKINES AND GROWTH FACTORS<br />
Platania P., Sem<strong>in</strong>ara G. 1 , Catania M.V. 1 , Sort<strong>in</strong>o M.A.<br />
Department of Experimental and Cl<strong>in</strong>ical Pharmacology, University of Catania,<br />
Catania, and 1 Institute of Neurological Sciences, CNR, Catania<br />
GLUCOCORTICOID-INDUCED LEUCINE ZIPPER OVEREXPRESSION<br />
DETERMINES A PERTURBATION OF THYMIC SUBSETS BY INCREASING<br />
THEIR APOPTOTIC TRESHOLD IN TRANSGENIC MICE<br />
Domenico V. Delf<strong>in</strong>o, Massimiliano Agost<strong>in</strong>i, Stefania Sp<strong>in</strong>icelli, Graziella Migliorati,<br />
Carlo Riccar<strong>di</strong><br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology,<br />
University of Perugia, Via del Giochetto, 06100 Perugia, Italy<br />
GROUP-II METABOTROPIC GLUTAMATE RECEPTORS REGULATE THE<br />
VULNERABILITY TO HYPOXIC BRAIN DAMAGE<br />
Poli A. 1 , Berau<strong>di</strong> A. 1 , Villani L. 1 , Storto M. 2 , DiGiorgi Gerev<strong>in</strong>i V. 3 , Cappuccio I. 3 ,<br />
Caricasole A. 3,4 , D’ Onofrio M. 2 2 ,3<br />
, Nicoletti F.<br />
1 Department of Biology, University of Bologna,<br />
99<br />
2 I.N.M. Neuromed, Pozzilli,<br />
Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”, and 4 SienaBiotech, Siena, Italy<br />
1 ; 3<br />
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page<br />
3<br />
43<br />
116<br />
81<br />
111<br />
42<br />
111
Poster<br />
n°<br />
325.<br />
326.<br />
327.<br />
328.<br />
329.<br />
330.<br />
331.<br />
IMAGING NITROSATIVE STRESS IN PRIMARY ASTROGLIAL CULTURES:<br />
PROTECTION OF ASTROGLIA FROM NITROSATIVE/OXIDATIVE STRESS-<br />
INDUCED CELL DEATH BY RED ORANGE EXTRACT<br />
1 Gennuso F, 1 Tirolo C, 1 Testa N, 1 L’Episcopo F., 1 Caniglia S, 1 Morale MC, 2 Puglisi<br />
C, 3 Scoto G, 4 Saia A, 2 Bon<strong>in</strong>a FP, 1,5 Marchetti B<br />
1 Neuropharmacology, OASI Inst.Tro<strong>in</strong>a (EN), 2 Dept. Pharmaceutical Sci. and 3<br />
Pharmacol. Fac. of Pharmacy, Univ. of Catania, 3 Dipt. Farmaco Biol. Fac. Pharmacy,<br />
Univ. of Mess<strong>in</strong>a, and 5 Dept. Pharmacol. Me<strong>di</strong>cal School, Univ of Sassari<br />
INCREASED EXPRESSION OF S100b PROTEIN BY MPTP IN ASTROGLIAL<br />
CELLS IS RESPONSIBLE FOR NEURONAL CELL DEATH<br />
Teresa Iuvone, Giuseppe Esposito, Massimo Di Rosa<br />
Dipartimento <strong>di</strong> Farmacologia Sperimentale, Via D. Montesano, 49, <strong>Università</strong> <strong>di</strong><br />
Napoli “Federico II”<br />
INFLAMMATORY RESPONSE AND INTESTINAL DISMOTILITY CAUSED BY<br />
EXPERIMENTAL ISCHEMIA/REPERFUSION INJURY IN RATS: POSSIBLE<br />
INVOLVEMENT OF NMDA RECEPTORS<br />
Calc<strong>in</strong>a F., 1 Stern<strong>in</strong>i C., Ghizzar<strong>di</strong> P., Bertoni S., Chiavar<strong>in</strong>i M., Cattaruzza F.,<br />
Ballabeni V., Impicciatore M., Barocelli E.<br />
Dip. Scienze Farmacologiche, Biologiche e Chimiche Appl. <strong>Università</strong> <strong>di</strong> Parma, Parco<br />
Area delle Scienze 27/A. 43100 Parma–Italy; 1 CURE Dig. Dis. Res. Centre, Division<br />
of Digestive Disease, Dep. Med. Neurobiol., University of California, Los Angeles, CA<br />
90095-USA<br />
NEUROTROPHIC FACTOR-INDEPENDENT SURVIVAL OF ADULT<br />
AUTONOMIC NEURONS IS MEDIATED BY MEMBRANE AND SUB-<br />
MEMBRANE REMODELING TRIGGERED BY LESIONING<br />
Anna Maria Di Giulio, C<strong>in</strong>zia Cichetti, Laura Madaschi, Alfredo Gorio<br />
Laboratory of Pharmacology, Dept. Me<strong>di</strong>c<strong>in</strong>e, Surgery and Dentistry, University of<br />
Milano, Via A <strong>di</strong> Rud<strong>in</strong>ì 8, 20142 Milano<br />
PROLIFERATION AND DIFFERENTIATION OF RAT LUNG CELLS DURING<br />
TISSUE REPAIR: A PHARMACOLOGICAL STUDY<br />
Lesma E., Grande V., P. Santus 1 , Centanni S. 1 , Di Giulio AM., Gorio A.<br />
Pharmacological laboratories and , Dept. Me<strong>di</strong>c<strong>in</strong>e, Surgery and Dentistry, Fac. of<br />
Me<strong>di</strong>c<strong>in</strong>e, Polo H. San Paolo, University of Milano; 1 Respiratory Unit, San Paolo<br />
Hospital, University of Milano<br />
ROLE OF Bcl-2 FAMILY PROTEINS ON IATROGENIC APOPTOSIS IN HUMAN<br />
UMBILICAL VEIN ENDOTHELIAL CELLS (HUVEC)<br />
Visent<strong>in</strong> B., V<strong>in</strong>ci M.C., Pigh<strong>in</strong> I., Trevisi L., Luciani S.<br />
Department of Pharmacology and Anaesthesiology, University of Padova, Largo E.<br />
Meneghetti, 2 - Padova (Italy)<br />
SELECTIVE A2A RECEPTOR ANTAGONISTS INHIBIT THE RAISE OF<br />
GLUTAMATE INDUCED BY UPTAKE INHIBITION IN THE RAT STRIATUM<br />
P<strong>in</strong>tor A., Galluzzo M 1 ., Grieco R., Pèzzola A., Reggio R., Popoli P.<br />
Department of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Roma, Italy , 1 School of<br />
Pharmacy, Pharmaco-Biological Department University of Mess<strong>in</strong>a Italy<br />
100<br />
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page<br />
66<br />
75<br />
20<br />
49<br />
78<br />
145<br />
110
Poster<br />
n°<br />
332.<br />
SURVIVAL AND FUNCTIONING OF PC12 CELLS FOLLOWING<br />
TRANSPLANTATION IN THE RAT STRIATUM<br />
Maria G. Taras, Rossana Migheli , Pier Andrea Serra, Gaia Rocchitta, Maria R.<br />
Delogu, Maria P. Mura, Giovanni Esposito, Maddalena Miele, Egi<strong>di</strong>o Miele, Maria S.<br />
Desole<br />
From the Department of Pharmacology, University of Sassari, 07100 Sassari<br />
333. TACHYKININ NEUROPEPTIDES IN CULTURED CEREBELLAR GRANULE<br />
NEURONS: FUNCTIONS AND LOCALIZATION<br />
Barbato C. 1,2 , Ciotti M.T. 1 , Seraf<strong>in</strong>o A. 1 , Mercanti D. 1 , Sever<strong>in</strong>i C. 1 1, 2<br />
, Calissano P.<br />
1<br />
Istituto <strong>di</strong> Neurobiologia e Me<strong>di</strong>c<strong>in</strong>a Molecolare, CNR, Viale Marx 15/43, 00137,<br />
Roma, Italia; 2 Dipartimento <strong>di</strong> Neuroscienze, <strong>Università</strong> <strong>di</strong> Roma Tor Vergata, 00173,<br />
Roma Italia<br />
334.<br />
335.<br />
336.<br />
TESTOSTERONE AMPLIFIES EXCITOTOXIC DAMAGE OF CULTURED<br />
OLIGODENDROCYTES<br />
Castiglione M. 1 , Caruso A. 1 , DiGiorgi Gerev<strong>in</strong>i V 1 , Mar<strong>in</strong>elli F. 2 , Tomass<strong>in</strong>i V. 2 ,<br />
Pozzilli C. 2 , Caricasole A. 1,3 , Nicoletti F. 1,4 , Melchiorri D. 1,4<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza", Rome Italy, 2 Department of Neurological Sciences, University of Rome “La<br />
Sapienza”, 3 Siena Biotech, Siena Italy, 4 INM Neuromed Pozzilli, Italy<br />
THE ROLE OF CYTOSOLIC PHOSPHOLIPASE A2 IN PEROXYNITRITE-<br />
INDUCED U937 CELL DEATH<br />
Tommas<strong>in</strong>i I., Sestili P., Guidarelli A., Cantoni O.<br />
Istituto <strong>di</strong> Farmacologia e Farmacognosia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urb<strong>in</strong>o “Carlo Bo”.<br />
Via S. Chiara 27, 61029 URBINO<br />
VESICULAR-LIKE GLUTAMATE RELEASE FROM HUMAN CEREBRAL<br />
CORTEX SLICES DURING ISCHEMIA: MODULATION BY 5-HT AND<br />
ADENOSINE<br />
Marcoli M., Bonfanti A., 1 Ong<strong>in</strong>i E., 1 Monopoli A., Castagnetti M., Maura G.,<br />
Raiteri M.<br />
Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Sperimentale, Sez. <strong>di</strong> Farmacologia e Tossicologia, Genova;<br />
1 Scher<strong>in</strong>g-Plough Research Institute, San Raffaele Science Park, Milano; present<br />
address: Nicox Research Institute, Bresso, Milano<br />
101<br />
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135<br />
7<br />
28<br />
138<br />
84
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Controllo farmacologico della morte cellulare e dei processi degenerativi.<br />
POSTER 337-355<br />
Moderatore: J. Meldolesi (Milano)<br />
Poster<br />
n°<br />
337.<br />
338.<br />
339.<br />
340.<br />
341.<br />
(-)-PHCCC, A POSITIVE ALLOSTERIC MODULATOR OF mGluR4:<br />
MECHANISM OF ACTION, AND NEUROPROTECTION<br />
V. Bruno 1 , 2 , M. Maj 3 , Z. Dragic 3 , G. Battaglia 2 , W. Inderbitz<strong>in</strong> 3 , F. Gaspar<strong>in</strong>i 3 , P.J.<br />
Flor 3 1 , 2<br />
, F. Nicoletti<br />
1 Department of Human Physiology and Pharmacology, University of Rome, Italy;<br />
Istituto Neurologico Me<strong>di</strong>terraneo - Neuromed, Pozzilli, Italy; 3 Novartis Institutes for<br />
BioMe<strong>di</strong>cal Research, Nervous System Research, Basel, Switzerland<br />
AMYLOID-ß PEPTIDE REDUCES THE EXPRESSION OF WNT TARGET GENES<br />
IN PC12 CELLS<br />
Caruso A 1 . Motolese M 1 . Melchiorri D 1 . G.C.Terstappen 3 , Nicoletti F 1 , 2 . and<br />
Caricasole A. 3<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”, Rome Italy, 2 I.N.M Neuromed Pozzilli, Italy, 3 Siena Biotech , Siena Italy<br />
ANTIOXIDANT ACTIVITY OF FLAVONOIDS AGAINST HYPOCHLOROUS<br />
ACID<br />
Firuzi O. 1 , Bianconi V. 1 , Dvorscakova M. 1 , Hauser A. 1 , Mladenka P. 1 , Petrucci R. 2 ,<br />
Marrosu G. 2 , Saso L. 1<br />
1 Dipartimento <strong>di</strong> Farmacologia delle Sostanze Naturali e Fisiologia Generale<br />
<strong>Università</strong> <strong>di</strong> Roma “La Sapienza”, P.le Aldo Moro 5, 00185 Roma; 2 Dipartimento <strong>di</strong><br />
Ingegneria C. M. M. P. M., <strong>Università</strong> <strong>di</strong> Roma “La Sapienza”<br />
ATTENUATION OF SECONDARY INJURY VERSUS REGENERATION: A<br />
MARKED NEUROLOGICAL RECOVERY PROMOTED BY ERYTHROPOIETIN<br />
AFTER EXPERIMENTAL SPINAL CORD TRAUMA<br />
Alfredo Gorio, Laura Madaschi, C<strong>in</strong>zia Cichetti, Anna Maria Di Giulio<br />
Laboratory of Pharmacology, Dept. Me<strong>di</strong>c<strong>in</strong>e, Surgery and Odontoiatry, Faculty of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Milan, Via A. Di Rud<strong>in</strong>i’ 8, 20142 Milan, Italy<br />
DEFECTIVE p53 APOPTOTIC PATHWAY IN FIBROBLASTS FROM SPORADIC<br />
ALZHEIMER’S DISEASE PATIENTS<br />
Uberti D., Carsana T., Bernar<strong>di</strong> E., Francisconi S., Lanni C.°, Racchi M.°, Govoni S.°,<br />
Memo M.<br />
Department of Biome<strong>di</strong>cal Sciences and Biotechnologies, University of Brescia,<br />
Brescia and °Department of Experimental and Applied Pharmacology, University of<br />
Pavia, Pavia, Italy<br />
102<br />
Abs. book<br />
page<br />
2<br />
17<br />
26<br />
58<br />
71<br />
141
Poster<br />
n°<br />
342.<br />
343.<br />
344.<br />
345.<br />
346.<br />
347.<br />
EVIDENCE THAT THE INDUCIBLE NITRIC OXIDE SYNTHASE IS INVOLVED<br />
IN THE MECHANISMS OF COCAINE ENHANCED NEURONAL APOPTOSIS<br />
CAUSED BY HIV-1 GP120 IN THE NEOCORTEX OF RAT<br />
Bagetta G. 1,2 , Piccirilli S. 2 , Del Duca C. 2 , Morrone L.A. 1 , Rombolà L. 1 , De Alba J. 3 ,<br />
Knowles R.G. 3 , Corasaniti M.T. 4<br />
1 2<br />
Department of Pharmacobiology, University of Calabria at Cosenza, Italy; IRCCS<br />
C. Mond<strong>in</strong>o, Experimental Neurobiology Center Mond<strong>in</strong>o-Tor Vergata-Santa Lucia,<br />
Rome; 3 Respiratory Pharmacology Department, GlaxoSmithKl<strong>in</strong>e Research,<br />
Stevenage, Hertfordshire, UK; 4 Department of Pharmacobiological Sciences,<br />
University Magna Graecia of Catanzaro, Italy<br />
HIF-1a BINDS INOS PROMOTER AND INCREASES INOS EXPRESSION<br />
DURING PMCAO IN HIPPOCAMPUS<br />
1 1 2 1 1 1<br />
Matrone C., Pignataro G., Irace C., Valsecchi V., Mol<strong>in</strong>aro P., Scorziello A.,<br />
1 1<br />
Di Renzo G.F., Annunziato L.<br />
1<br />
Division of Pharmacology, Department of Neuroscience, School of Me<strong>di</strong>c<strong>in</strong>e,<br />
2<br />
Department of Experimental Pharmacology, School of Pharmacy, “Federico II”<br />
University Naples, Italy<br />
INCREASED CASPASE ACTIVATION IN LYMPHOCYTES OF PATIENTS WITH<br />
ALZHEIMER’S DISEASE<br />
Tacconi Sant<strong>in</strong>a 1 , Balestrieri Emanuela 2 Perri Roberta 3 , Mast<strong>in</strong>o Antonio 2 ,<br />
Caltagirone Carlo 3 ,4 , Macchi Beatrice<br />
3 ,4<br />
1 Dep of Exp. Med. and Bioch. Sci. Univ of Rome “Tor Vergata”, Rome; 2 Dep. of<br />
Microb., Gen. and Mol. Sci. Univ. of Mess<strong>in</strong>a, Mess<strong>in</strong>a; 3 IRCCS S.Lucia, Rome; 4<br />
Dep.of Neurosc., Univ. of Rome “Tor Vergata”, Rome. Italy<br />
INDUCTION OF DKK1, A WNT ANTAGONIST, IN ß-AMYLOID-TREATED<br />
NEURONAL CULTURES<br />
1 2 3 4 4 4<br />
Caraci F., Caricasole A, Storto M, Caruso A., Cappuccio I., Melchiorri D.,<br />
5 1 3 ,4<br />
Sort<strong>in</strong>o MA. Copani A, Nicoletti F.<br />
1 2 3<br />
Dept. Pharm. Sciences, University of Catania; SienaBiotech, Siena; I.N.M.<br />
Neuromed, Pozzilli; 4 Dept. Human Physiol. and Pharmacol., University of Rome “La<br />
Sapienza”; 5 Dept. Cl<strong>in</strong>. Exp. Pharmachology, University of Catania<br />
INVOLVEMENT OF ANNEXIN-1 IN THE APOPTOSIS INDUCED BY<br />
GLUCOCORTICOIDS IN OSTEOBLASTS<br />
Festa M., Petrella A., Ricciar<strong>di</strong> R., Solito E., Parente L.<br />
Dipartimento <strong>di</strong> Scienze Farmaceutiche, Facoltà <strong>di</strong> Farmacia, <strong>Università</strong> <strong>di</strong> Salerno.<br />
MELANOCORTINS REDUCE THE BRAIN DAMAGE CONSEQUENT TO<br />
TRANSIENT GLOBAL CEREBRAL ISCHEMIA<br />
Giuliani D. 1 , Mioni C. 1 , Leone S. 1 , Altavilla D. 2 , Ca<strong>in</strong>azzo M.M. 1 , Bazzani C. 1 ,<br />
Botticelli A.R. 3 , Zaffe D. 4 , Schiöth H.B. 5 , Bertol<strong>in</strong>i A. 1 , Squadrito. F 2 , Guar<strong>in</strong>i S 1<br />
1 Dept. Biome<strong>di</strong>cal Sciences, Sections of Pharmacology, 4 Dept. Morphological Sci. and<br />
Forensic Med., University of Modena and Reggio Emilia, Modena; 3 Dept of Human<br />
Phatology University of Pavia, Pavia; 2 Dept. Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and<br />
Pharmacology, Section of Pharmacology, University of Mess<strong>in</strong>a, Mess<strong>in</strong>a, Italy; 5 Dept.<br />
of Neuroscience.Uppsala, Sweden<br />
103<br />
Abs. book<br />
page<br />
6<br />
87<br />
134<br />
24<br />
57<br />
70
Poster<br />
n°<br />
348.<br />
349.<br />
350.<br />
351.<br />
352.<br />
353.<br />
354.<br />
METABOTROPIC GLUTAMATE RECEPTOR LIGANDS ARE PROTECTIVE IN<br />
EXPERIMENTAL ANIMAL MODELS OF PARKINSON’S DISEASE<br />
Giuseppe Battaglia 1 , Francesco Fornai 1,2 , Carla L. Busceti 1 , Fabrizio Pontarelli 1 ,<br />
Francesca Biagioni 1 , Stefano Pagano 3 , Eugenio Parati 3 Valeria Bruno 1,4 , Ferd<strong>in</strong>ando<br />
Nicoletti 1,4<br />
1 I.N.M. Neuromed, Pozzilli; 2 Department of Human Morphology and Applied<br />
Biology, University of Pisa; 3 I.N.N. “C. Besta”, Milano; 4 Department of Human<br />
Physiology and Pharmacology, University of Roma “La Sapienza”, Roma, Italy<br />
MODULATORY ACTIVITY OF MUTANT HUNTINGTIN ON LIPID<br />
METABOLISM<br />
Rigamonti D. 1 , Valenza M. 1,2 , Fenu S. 1 , Sipione S. 1 , Conti L. 1 , Racchi M. 2 ,<br />
Cors<strong>in</strong>i A. 1 , Zuccato C. 1 , Cattaneo E. 1<br />
1 Department of Pharmacological Sciences and Center of Excellence on<br />
Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano,<br />
Italy; 2 Department of Pharmacology, University of Pavia<br />
NEUROPROTECTIVE EFFECTS OF CABERGOLINE ON ISCHEMIA-INDUCED<br />
CELL DEATH: IN VITRO STUDIES<br />
Francioli E. 1 , Miglio G 1 ., Varsal<strong>di</strong> F. 1 , Pap<strong>in</strong>i M.G. 2 , Battaglia A. 2 , Canonico P.L. 1<br />
, Lombar<strong>di</strong> G. 1<br />
1 DISCAFF Department, University of “Piemonte Orientale”, Novara, Italy; 2 Me<strong>di</strong>cal<br />
Department, Pharmacia Italia S.p.a., Milano, Italy<br />
OLFACTORY MEMORY FUNCTION IN MICE EXPRESSING A MUTATED<br />
HUMAN APP TRANSGENE<br />
T. Humby 1 , T. Cassano 2 , T. Burne 1 , V. Cuomo 3 , L. Wilk<strong>in</strong>son 1<br />
1 Lab. of Cognitive and Developmental Neuroscience, The Babraham Institure,<br />
Cambridge, U.K.; 2 Dept. of Biome<strong>di</strong>cal Sciences, University of Foggia, Italy; 3 Dept.<br />
of Pharmacology of Natural Substances and General Physiology, University of Rome<br />
“La Sapienza”, Italy<br />
PrP 106-126-INDUCED APOPTOSIS IS MEDIATED BY THE ACTIVATION OF<br />
p38 MAP KINASE AND INDEPENDENT FROM AMYLOID FIBRIL FORMATION<br />
Villa V. 1 , Corsaro A. 1 , Thellung S. 1 , Aceto A. 3 , Palu<strong>di</strong> D. 3 , Rossi Pr<strong>in</strong>cipe D. 3 ,<br />
Schett<strong>in</strong>i G. 1 , 2 , Florio T. 1,2<br />
1 2<br />
Sect. Pharmacology, Dept. Oncology, Biology and Genetics University of Genova,<br />
Pharmacology and Neuroscience IST Genova, 3 Dept. Biome<strong>di</strong>cal Sciences, University<br />
G. D'Annunzio, Chieti, Italy<br />
SHC(S) ROLES IN NEURAL STEM/PROGENITOR CELLS DIVISION AND<br />
DIFFERENTIATION<br />
Conti L., Cataudella T., De Micheli A., Reitano E.,Baj G., Cattaneo E.<br />
Department of Pharmacological Sciences and Center of Excellence on<br />
Neurodegenerative Disorders, University of Milano<br />
ß-AMYLOID-ACTIVATED CELL CYCLE IN SH-SY5Y NEUROBLASTOMA<br />
CELLS: CORRELATION WITH THE MAP KINASE PATHWAY<br />
Frasca G. 1,2 , Chiechio S 1 ., Sort<strong>in</strong>o M.A. 2 , Copani A. 1<br />
Departments of 1 Pharmaceutical Sciences, section of Pharmacology and 2<br />
Experimental and Cl<strong>in</strong>ical Pharmacology, University of Catania, Italy<br />
104<br />
Abs. book<br />
page<br />
9<br />
117<br />
60<br />
74<br />
145<br />
36<br />
60
Poster<br />
n°<br />
355.<br />
THE ROLE OF Na + /Ca 2+ EXCHANGER ENCODING GENES NCX1, NCX2 AND<br />
NCX3 IN CEREBRAL ISCHEMIA: MOLECULAR AND PHARMACOLOGICAL<br />
CHARACTERIZATION<br />
Pignataro G, Gala R, Castaldo P, Tortiglione A., Di Renzo GF, Annunziato L.<br />
Division of Pharmacology, Department of Neuroscience, School of Me<strong>di</strong>c<strong>in</strong>e, “Federico<br />
II” University of Naples<br />
105<br />
Abs. book<br />
page<br />
109
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 2B<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia dei <strong>di</strong>sord<strong>in</strong>i neurologici e psichiatrici.<br />
POSTER 356-377<br />
Moderatore: P. Geppetti (Firenze).<br />
Poster<br />
n°<br />
356.<br />
357.<br />
358.<br />
359.<br />
360.<br />
361.<br />
A NEUROPHYSIOLOGICAL APPROACH TO THE “PHOSPHENE”<br />
PHENOMENON THROUGH ACCELERATED PARTICLES ADMINISTERED TO<br />
ANAESTHETISED MICE<br />
Guar<strong>in</strong>o I., Capasso A., De Iovanna M.A., Loizzo S., Lopez L., Pedrazzo G., Loizzo<br />
A.<br />
Istituto Superiore <strong>di</strong> Sanità, Roma; Dipartimento <strong>di</strong> Scienze Farmaceutiche, <strong>Università</strong><br />
<strong>di</strong> Salerno<br />
A NEW IN VITRO NEURONAL MODEL TO STUDY TAU ABNORMAL<br />
POSTRASCRIPTIONAL MODIFICATION<br />
Paccioretti S., Uberti D., Memo M.<br />
Dipartimento Scienze Biome<strong>di</strong>che e Biotecnologie, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Brescia<br />
ACTIVATION OF SEROTONINERGIC 5-HT4 RECEPTOR SYSTEM AND<br />
MEMORY PERFORMANCE<br />
Ferri S., Orsetti M. 1 , Dellarole A. 1 Ghi P.<br />
Dip. Anatomia, Farmacologia e Me<strong>di</strong>c<strong>in</strong>a Legale, <strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o; 1 Dip. Scienze<br />
C.A.F. e Farmacologiche , <strong>Università</strong> del Piemonte Orientale, Novara<br />
ALPHA-SYNUCLEIN AND 6-HYDROXY-DOPAMINE: TWO DIFFERENT<br />
MODELS TO STUDY IN VIVO PARKINSON’S DISEASE<br />
Recchia A. 1 , Negro A. 2 , Guidol<strong>in</strong> D. 3 , Debetto P. 1 , and Giusti P. 1<br />
1 Dept of Pharmacology and Anesthesiology, 2 CRIBI, and 3 Dept of Human Anatomy<br />
and Physiology, University of Padova<br />
ANTI-PRIONIC ACTIVITY OF CLIOQUINOL IN THE TRANSMISSIBLE<br />
SPONGIFORM ENCEPHALOPATHY (TSE)<br />
Bareggi S.R. 1 , Sala M. 1 , Pollera C. 2 , Ponti W. 2 , Braida D. 1 , Gervasoni M. 1 , Poli G. 2 ,<br />
Mantegazza, P 1<br />
1 Dep. of Me<strong>di</strong>cal Pharmacology, Chemotherapy and Toxicology, and 1 Dep. of Animal<br />
Pathology, Microbiology and Immunology Unit, University of Milan, Italy<br />
CYTOCHROME P450-DEPENDENT METABOLISM OF L-DEPRENYL IN<br />
MONKEY (CERCOPITHECUS AETHIOPS) AND C57BL/6 MOUSE BRAIN<br />
MICROSOMAL PREPARATIONS<br />
Dragoni S, Bellik L, Fros<strong>in</strong>i M, Matteucci G, Sgaragli G, Valoti M<br />
Dipartimento <strong>di</strong> Scienze Anatomiche e Biome<strong>di</strong>che, Univeristà <strong>di</strong> Siena, Italy<br />
106<br />
Abs. book<br />
page<br />
72<br />
100<br />
57<br />
116<br />
8<br />
52
Poster<br />
n°<br />
362.<br />
363.<br />
364.<br />
365.<br />
366.<br />
367.<br />
368.<br />
DEVELOPMENTAL EXPOSURE TO THE ANTIRETROVIRAL DRUG<br />
ZIDOVUDINE (AZT) ALTERS RESPONSIVENESS TO THE D1 AGONIST SKF<br />
38393 IN MICE<br />
Calamandrei G., Valanzano A., Puopolo M., Venerosi A.<br />
Section of Comparative Psychology, Laboratory of Pathophysiology, Dep. of Cell<br />
Biology and Neurosciences, Istituto Superiore <strong>di</strong> Sanità, Viale Reg<strong>in</strong>a Elena 299, 00161<br />
ROMA (Italy)<br />
DIFFERENTIAL INVOLVEMENT OF PROTEIN KINASE C ALPHA AND<br />
EPSILON IN THE REGULATED SECRETION OF SOLUBLE<br />
AMYLOIDPRECURSOR PROTEIN<br />
Michela Mazzucchelli, Stefano Govoni, Silvia Paro<strong>di</strong>, Crist<strong>in</strong>a Lanni, Emanuela<br />
Porrello, Marco Racchi<br />
Dipartimento <strong>di</strong> Farmacologia Sperimentale ed Applicata, <strong>Università</strong> <strong>di</strong> Pavia<br />
EFFECTS OF FLURBIPROFEN AND ITS NO-DERIVATIVES HCT-1026 AND<br />
NCX-2216 ON BRAIN INFLAMMATION INDUCED BY Ab(1-42) INJECTION<br />
INTO THE NUCLEUS BASALIS OF RATS<br />
Prosperi C. 1 , Scali C. 1 , Barba M. 2 , Giovann<strong>in</strong>i M.G. 1 , Pepeu G. 1 , Casamenti F. 1<br />
1 Dept. of Pharmacology, University of Florence, Viale Pieracc<strong>in</strong>i, 6, 50139, Florence,<br />
Italy; 2 Nicox Research Institute, Via Ariosto 21, 20019 Bresso Milan, Italy<br />
EGR-1 EXPRESSION AND LOCALIZATION INDUCED BY LEARNING,<br />
MEMORY AND AMNESIC DRUGS IN THE RAT BRAIN: AN<br />
IMMUNOHISTOCHEMICAL STUDY<br />
Dellarole A., Ghi P. 1 , Ferri S. 1 , Orsetti M.<br />
Dip. Scienze C.A.F. e Farmacologiche , <strong>Università</strong> del Piemonte Orientale, Novara; 1<br />
Dip. Anatomia, Farmacologia e Me<strong>di</strong>c<strong>in</strong>a Legale, <strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o<br />
FUNCTIONAL AND MOLECULAR CORRELATIONS BETWEEN DNA REPAIR<br />
ALTERATIONS AND OXIDATIVE STRESS IN THE CNS<br />
Francisconi S., Ferrari Ton<strong>in</strong>elli G., Codenotti M., Memo M.<br />
Dipartimento Scienze Biome<strong>di</strong>che e Biotecnologie, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Brescia<br />
IN VITRO STUDY OF THE INTERACTION BETWEEN MEPACRINE AND<br />
PUTRESCINE: A POSSIBLE TOOL AGAINST TRANSMISSIBLE SPONGIFORM<br />
ENCEPHALOPATHIES<br />
Coppi A. 2 , Rossi T. 1 , Zandomeneghi G. 2 , Ruberto I.A. 2 , Baggio G. 2 , Castelli M. 2<br />
2 Section of Pharmacology, Department of Biome<strong>di</strong>cal Sciences, via Campi 287<br />
Modena, and 1 Department of Pharmaceutical Sciences, via Campi 183, University of<br />
Modena and Reggio Emilia, Italy<br />
INHIBITION OF RABBIT BRAIN g–AMINOBUTYRIC ACID<br />
AMINOTRANSFERASE BY SOME STRUCTURALLY RELATED ANALOGUES<br />
OF TAURINE<br />
Ricci L., Fros<strong>in</strong>i M., Valoti M., Sgaragli G.P.<br />
Dipartimento <strong>di</strong> Scienze Anatomiche e Biome<strong>di</strong>che, <strong>Università</strong> <strong>di</strong> Siena, Nuovo Polo<br />
Scientifico, Italy<br />
107<br />
Abs. book<br />
page<br />
20<br />
90<br />
114<br />
43<br />
60<br />
37<br />
117
Poster<br />
n°<br />
369.<br />
370.<br />
371.<br />
372.<br />
373.<br />
374.<br />
375.<br />
INTERACTION BETWEEN CARBOXY-TERMINAL FRAGMENTS OF APP AND<br />
SHCA, GRB2 ADAPTOR PROTEINS IN THE BRAIN OF DOWN'S SYNDROME<br />
PATIENTS<br />
Dolc<strong>in</strong>i V., Olivieri K., Venezia V., Salis S., Repetto E., Genova F., Nizzari M., Russo<br />
C., Schett<strong>in</strong>i G.<br />
Pharmacology and Neuroscience National Cancer Institute (IST) c/o Advanced<br />
Biotechnology Center and Section of Pharmacology Department of Oncology, Biology<br />
and Genetics University of Genova, Italy<br />
LONG TERM EVALUATION OF BEHAVIOURAL AND<br />
NEUROPATHOLOGICAL CHANGES IN THE QUINOLINIC RAT MODEL OF<br />
HUNTINGTON’S DISEASE<br />
Scattoni M.L. 1 , Valanzano A. 1 , Popoli P. 2 , Pezzola P. 2 , Reggio R., Calamandrei G. 1<br />
1 2<br />
Department of Cell Biology and Neurosciences and Department of Pharmacology;<br />
Istituto Superiore <strong>di</strong> Sanità, Viale Reg<strong>in</strong>a Elena 299, I-00161 Roma (Italy)<br />
NEUROCHEMICAL AND BEHAVIORAL EFFECTS OF GANSTIGMINE AND<br />
OTHER CHOLINESTERASE INHIBITORS IN RATS<br />
T. Cassano 1 , M.R. Carratù 2 , A. Coluccia 2 , A. Giust<strong>in</strong>o 2 , S. Gaetani 3 , B.P. Imbimbo 4<br />
, C.F. de la Riva 5 , G. Villetti 4 , K.M. Kendrick 5 , V. Cuomo 3<br />
1 2 3<br />
Dept. of Biomed Sciences, Univ. of Foggia; Dept. of Pharmacol., Univ. of Bari;<br />
Dept. of Pharmacol., Univ. of Rome “La Sapienza”; 4 Dept. of Pharmacol., Chiesi<br />
Farmaceutici S.p.A., Parma; 5 The Babraham Institute, Cambridge, U.K.<br />
NICOTINE AND DEPRESSION: LONG-TERM EFFECTS OF NICOTINE ON<br />
FORCED SWIMMING TEST<br />
Mannucci C., Catania M.A., Caputi A.P., Calapai G.<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology, School of<br />
Me<strong>di</strong>c<strong>in</strong>e, University of Mess<strong>in</strong>a, Italy<br />
PROTECTIVE EFFECT OF IRFI 042 IN KAINIC ACID INDUCED<br />
NEUROTOXICITY IN RAT<br />
Mar<strong>in</strong>i H, Passaniti M, Esposito M, Altavilla D, Caputi AP, Squadrito F<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy<br />
ROLE OF mRNA STABILIZATION BY THE HuD PROTEIN IN THE ENCODING<br />
PHASE OF SPATIAL LEARNING<br />
A. Pascale, M.Ama<strong>di</strong>o, P.A. Gusev 1 , D.L. Alkon 1 , S. Govoni, A.Quattrone 2<br />
Experimental and Applied Pharmacology Department, Pavia, Italy; 1 Blanchette<br />
Rockefeller Neuroscience Institute, Rockville, USA; 2 Me<strong>di</strong>cal Genetics Service,<br />
Department of Cl<strong>in</strong>ical Pathology, IRCCS CSS, S. Giovanni Rotondo (FG), Italy<br />
SELECTIVE IMPAIRMENT OF NORADRENERGIC TRANSMISSION BY<br />
PHOTOCHEMICALLY INDUCED CEREBRAL ISCHEMIA IN THE BISECTED<br />
RAT VAS DEFERENS<br />
Boselli C., Preda S., Rozza A., Favalli L., Cond<strong>in</strong>o A.M, Govoni S., D’ Agost<strong>in</strong>o G<br />
Department of Experimental and Applied Pharmacology, School of Pharmacy,<br />
University of Pavia, Pavia, Italy<br />
108<br />
Abs. book<br />
page<br />
50<br />
127<br />
27<br />
82<br />
84<br />
104<br />
15
Poster<br />
n°<br />
376.<br />
377.<br />
THE SELECTIVE MGLU5 RECEPTOR ANTAGONIST MPEP SHOWS<br />
NEUROPROTECTIVE EFFECTS IN A RAT MODEL OF HUNTINGTON’S<br />
DISEASE<br />
Popoli P., P<strong>in</strong>tor A., Tebano M.T., Frank C., Pepponi R., Grieco R., Nazzicone V.,<br />
Pèzzola A., Reggio R.<br />
Department of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Roma (Italy)<br />
TORSIN-A INTERACTS WITH MAP PROTEINS IN SH-SY5Y<br />
NEUROBLASTOMA CELLS<br />
Ferrari Ton<strong>in</strong>elli G., Paccioretti S., Uberti D., Codenotti M., Memo M.<br />
Dipartimento Scienze Biome<strong>di</strong>che e Biotecnologie, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Brescia<br />
109<br />
Abs. book<br />
page<br />
113<br />
57
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 3A<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia <strong>degli</strong> autacoi<strong>di</strong> e immunofarmacologia.<br />
POSTER 378-401<br />
Moderatori: E. Mas<strong>in</strong>i (Firenze) - L. Parente (Salerno)<br />
Poster<br />
n°<br />
378.<br />
379.<br />
380.<br />
381.<br />
5-LIPOXYGENASE KNOCKOUT MICE EXHIBIT A RESISTANCE TO<br />
SPLANCHNIC ARTERY OCCLUSION (SAO) SHOCK<br />
Rossi A. 1 , Cuzzocrea S. 2 , Serra<strong>in</strong>o I. 2 , DiPaola R. 2 , Genovese T. 2 , Caputi A.P. 2<br />
Sauteb<strong>in</strong> L. 1<br />
1 2<br />
Department of Experimental Pharmacology University of Naples Federico II;<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a<br />
ALTERED CORTISOL SECRETION ASSOCIATED WITH ASPIRIN-RESISTANT<br />
THROMBOXANE BIOSYNTHESIS AND SYSTEMIC INFLAMMATION IN<br />
ACUTE CORONARY SYNDROMES<br />
Tacconelli S, Renda G, Sciulli MG, § Rebuzzi A, Patrignani P<br />
Department of Me<strong>di</strong>c<strong>in</strong>e & Ag<strong>in</strong>g and Center of Excellence on Ag<strong>in</strong>g, “G.<br />
D’Annunzio” University, Chieti, and § Department of Car<strong>di</strong>ology, Catholic University,<br />
Rome, Italy<br />
THE EFFECT OF PROSTAGLANDIN J2 AND 2-CYCLOPENTEN-1-ONE ON<br />
RESTENOSIS IN A RAT MODEL OF ANGIOPLASTY<br />
Ialenti A. 1 , Ianaro A. 1 , Maffia P. 1 , Grassia G. 1 , Cuzzocrea S. 2 , Santoro M.G. 3 , Di<br />
Rosa M. 1<br />
1 Department of Experimental Pharmacology, University of Naples Federico II, Italy; 2<br />
Institute of Pharmacology, University of Mess<strong>in</strong>a, Italy; 3 Department of Biology,<br />
University of Rome Tor Vergata, Italy<br />
REACTIVE OXYGEN SPECIES MEDIATE COX-2 INDUCTION DURING<br />
MONOCYTE TRANSITION INTO MACROPHAGES: CRITICAL ROLE FOR<br />
NADPH OXIDASE<br />
Barbieri S.S., Elig<strong>in</strong>i S., Brambilla M., Tremoli E., Colli S.<br />
E. Grossi Paoletti Center, Department of Pharmacological Sciences and Department of<br />
Car<strong>di</strong>ac Surgery, Centro Car<strong>di</strong>ologico Fondazione Monz<strong>in</strong>o I.R.C.C.S., University of<br />
Milan, Italy<br />
110<br />
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120<br />
134<br />
74<br />
7
Poster<br />
n°<br />
382.<br />
383.<br />
384.<br />
385.<br />
386.<br />
387.<br />
388.<br />
ROLE OF 5-LIPOXYGENASE IN THE MULTIPLE ORGAN FAILURE INDUCED<br />
BY ZYMOSAN<br />
Sauteb<strong>in</strong> L. 1 , Cuzzocrea S. 2 , Rossi A. 1 , Serra<strong>in</strong>o I. 2 , DiPaola R. 2 , Britti D. 3 , Caputi<br />
A.P. 2<br />
1 2<br />
Department of Experimental Pharmacology University of Naples Federico II;<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a; 3 Department of Cl<strong>in</strong>ical Veter<strong>in</strong>ary Science University of Teramo<br />
LEUKOTRIENE SYNTHESIS IN HUMAN NEUTROPHILS: EFFECT OF CELL-<br />
CELL INTERACTIONS AND ADHESION MOLECULE SIGNALING<br />
Angelo Sala, Robert C. Murphy, Alessio Veltri, Peter M. Henson<br />
Center for Car<strong>di</strong>opulmonary Pharmacology, Department of Pharmacological Sciences,<br />
University of Milan, MILAN, and Division of Basic Science, Department of Pe<strong>di</strong>atrics,<br />
National Jewish Me<strong>di</strong>cal & Research Center, Denver, CO80206, U.S.A.<br />
LICOFELONE HAS ANTI-INFLAMMATORY ACTIVITY IN THE “AIR-POUCH”<br />
MODEL AND INHIBITS THE PRODUCTION OF LEUKOTRIENES,<br />
PROSTANOIDS, TNFa, AND MACROPHAGE MIGRATION<br />
Ottani A., Bertol<strong>in</strong>i A. 1 , Salt<strong>in</strong>i S., Filaferro M., Genedani S.<br />
Department of Biome<strong>di</strong>cal Sciences, Section of Pharmacology, Via Campi, 287 and 1<br />
Department of Internal Me<strong>di</strong>c<strong>in</strong>e, Section of Cl<strong>in</strong>ical Pharmacology and Toxicology,<br />
Via del Pozzo, 71; University of Modena and Reggio Emilia, 41100 Modena, Italy<br />
LTD4-INDUCED PROLIFERATION IN HUMAN AIRWAY SMOOTH MUSCLE<br />
CELLS IS DEPENDENT UPON TRANSACTIVATION OF THE EGF RECEPTOR<br />
AND ACTIVATION OF THE MAPK CASCATE<br />
Citro S., Ravasi S., Capra V., Rovati G.E.<br />
Laboratory of Molecular Pharmacology, Dept. of Pharmacological Sciences, University<br />
of Milan, Via Balzaretti 9, 20133 Milan, Italy<br />
NEGATIVE REGULATION OF NITRIC OXIDE FORMATION BY CYTOSOLIC<br />
PHOSPHOLIPASE A2 - RELEASED ARACHIDONIC ACID<br />
1 2 3 3 2 1<br />
Palomba L., Bianchi M., Persich<strong>in</strong>i T., Colasanti M., Magnani M., Cantoni O.<br />
1 2<br />
Istituto <strong>di</strong> Farmacologia e Farmacognosia, Istituto <strong>di</strong> Chimica Biologica “G.<br />
Forna<strong>in</strong>i”, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urb<strong>in</strong>o “Carlo Bo”, Urb<strong>in</strong>o; 3 Dipartimento <strong>di</strong><br />
Biologia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Roma III, Roma<br />
EFFECTS OF COX-2 INHIBITION ON THE ET-1- AND ET-3–INDUCED<br />
PULMONARY HYPERTENSION AND BRONCHOCONSTRICTION IN THE<br />
GUINEA PIG<br />
Del Basso P, Fabi F<br />
Laboratory of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Roma<br />
EVIDENCE OF A PROTECTIVE ROLE FOR ADENOSINE A2a RECEPTOR IN<br />
CARRAGEENIN-INDUCED RAT PAW EDEMA<br />
Vellecco V., Morello S., Iuvone T., Sorrent<strong>in</strong>o L., Cicala C<br />
Dipartimento Farmacologia Sperimentale, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Napoli “Federico<br />
II”, via D.Montesano 49, 80131 Naples, ITALY<br />
111<br />
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126<br />
123<br />
100<br />
35<br />
102<br />
42<br />
143
Poster<br />
n°<br />
389.<br />
390.<br />
391.<br />
392.<br />
393.<br />
394.<br />
395.<br />
ANTI-INFLAMMATORY EFFECT OF NEW PDE4 INHIBITORS WITHOUT<br />
PHERIPHERIC HYPERALGESIC EFFECTS<br />
1 1 1 2<br />
Stefano Pieretti, Luigi Dom<strong>in</strong>ici, Amalia Di Giannuario, Maria Paola<br />
Giovannoni and 2 Vittorio Dal Piaz<br />
1 2<br />
Department of Pharmacology, Istituto Superiore <strong>di</strong> Sanità, Rome; Department of<br />
Pharmaceutical Science, University of Florence, Florence, Italy<br />
ANTINFLAMMATORY EFFECTS AND VASORELAXATION INDUCED BY RED<br />
WINE<br />
Di Gennaro A., Fumagalli F., Buccellati C., Valenti M., Sala A., Folco GC<br />
Center for Car<strong>di</strong>opulmonary Pharmacology, University of Milan, Milan, Italy<br />
ANTI-INFLAMMATORY ACTIVITY OF 15-DEOXY-D 12, 14 – PGJ2 AND 2-<br />
CYCLOPENTEN-1-ONE: ROLE OF THE HEAT SHOCK RESPONSE<br />
Ianaro A. 1 , Ialenti A 1 ., Maffia P 2 ., Di Meglio P 1 ., Di Rosa M 1 ., Santoro MG 3 .<br />
1 Department of Experimental Pharmacology, University of Naples Federico II, Naples,<br />
Italy; 2 Department of Pharmaceutical Sciences, University of Salerno, Italy; 3<br />
Department of Biology, University of Rome Tor Vergata, Rome, Italy<br />
ANTI-INFLAMMATORY DRUGS DIFFERENTIALLY AFFECT TNF-ALPHA<br />
RELEASE AND NF-KB ACTIVATION IN BLOOD MONONUCLEAR CELLS<br />
Gunella G., Sp<strong>in</strong>a S., Lavagno L., Viano I., Brunelleschi S.<br />
Dept. Me<strong>di</strong>cal Sciences, University of Piemonte Orientale “A. Avogadro”, Via Solaroli,<br />
17 – 28100 Novara<br />
ANTIOXIDANT AND ANTINFLAMMATORY EFFECT OF CYANIDIN-3-O-<br />
GLUCOSIDE FROM BLACKBERRY EXTRACT<br />
1 Serra<strong>in</strong>o I., 2 Rossi A., 3 Paola Dugo, 1 Rosanna DiPaola, 4 Luigi Mondello, 1 Tiziana<br />
Genovese, 4 Domenica Morabito, 4 Giovanni Dugo, 2 Li<strong>di</strong>a Sauteb<strong>in</strong>, 1 Achille P.<br />
Caputi, 1 Salvatore Cuzzocrea<br />
1 Dept. of Pharmacology, University of Mess<strong>in</strong>a, Italy. 2 Dept. of Pharmacology,<br />
University of Naples, Italy. 3 Dept. of Pharmacology and Chemistry and 4 Dept. of<br />
Biological and Organic Chemistry, University of Mess<strong>in</strong>a, Italy<br />
CYSLT2 RECEPTOR ACTIVATION IN BRAIN INFLAMMATORY REACTIONS<br />
AND CEREBRAL EDEMA FORMATION: A ROLE FOR TRANSCELLULAR<br />
BIOSYNTHESIS OF CYSTEINIL-LEUKOTRIENES<br />
Carn<strong>in</strong>i C. 1 , Di Gennaro A. 1 , Buccellati C. 1 , Murphy R.C. 2 , Constant<strong>in</strong> G. 3 , De<br />
Curtis M. 4 , Folco G. 1 , Sala A. 1<br />
1 Center for Car<strong>di</strong>opulmonary Pharmacology and Dept. of Pharmacological Sciences,<br />
University of Milan, Italy; 2 National Jewish Me<strong>di</strong>cal and Research Center, Denver,<br />
U.S.A.; 4 Ist. Neurologico Besta, Milan, Italy; 3 Dept. of Pathology, University of<br />
Verona, Italy<br />
DNA VACCINATION THROUGH ELECTROPORATION AGAINST HER-2/NEU<br />
P185 PROTECTS SYRIAN HAMSTERS FROM DEVELOPMENT OF ORAL<br />
TUMOR INDUCED BY INJECTION OF TUMOR CELLS<br />
Mognetti B, Spadaro M, Berta GN, Corvetti G, Cavallo F, Di Carlo F<br />
Dept. of Cl<strong>in</strong>ical and Biological Sciences, University of Tur<strong>in</strong>, Italy<br />
112<br />
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109<br />
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74<br />
73<br />
129<br />
25<br />
94
Poster<br />
n°<br />
396.<br />
397.<br />
398.<br />
399.<br />
400.<br />
401.<br />
EFFECT OF METHYLGUANIDINE ON CARRAGEENAN-INDUCED LUNG<br />
INJURY<br />
1 2 2 3 1 1<br />
Marzocco S., Serra<strong>in</strong>o I., Cuzzocrea S., Sorrent<strong>in</strong>o R., P<strong>in</strong>to A., Autore G.<br />
1 2<br />
Dept. of Pharmaceutical Science, University of Salerno, Italy. Institute of<br />
Pharmacology, University of Mess<strong>in</strong>a, Italy. 3 Dept. of Experimental Pharmacology,<br />
University of Naples "Federico II", Italy<br />
INHIBITION OF NITRIC OXIDE SYNTHASE YUCCAOL A AND C ISOLATED<br />
FROM YUCCA SCHIDIGERA ROEZL<br />
Marzocco S. 1 , Piacente S. 1 , Pizza C. 1 , Oleszek W. 2 , Stochmal A. 2 , Sorrent<strong>in</strong>o R. 3 ,<br />
P<strong>in</strong>to A. 1 , Autore G. 1<br />
1 2<br />
Dept. of Pharmaceutical Science, University of Salerno, Italy.<br />
Dept. of<br />
Biochemistry, IUNG, Pulawy, Poland. 3 Dept. of Experimental Pharmacology,<br />
University of Naples "Federico II", Italy<br />
GILZ (GLUCOCORTICOID-INDUCED LEUCINE ZIPPER) INDUCES G0C1 CELL<br />
CYCLE ARREST BY INTERFERRING WITH MAPK PATHWAY<br />
Ayrol<strong>di</strong> E., Zollo O., Di Marco B., Massetti M., Sant<strong>in</strong>i C., Riccar<strong>di</strong> C.<br />
Department of Cl<strong>in</strong>ical and Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology,<br />
University of Perugia, Via del Giochetto, 06100 Perugia, Italy<br />
INTERLEUKIN 1 BETA AND 6 INDUCES FUNCTIONAL ALTERATION OF RAT<br />
COLONIC MOTILITY. AN IN VITRO STUDY.<br />
A.L. Piepoli 1 , L. Natale 1 , M.A. De Salvia 1 , G. De Salvatore 1 , C.I. Mitolo 1 , A.<br />
Marzullo 2 , P. Port<strong>in</strong>casa 3 , A. Moschetta 3 , G. Palasciano 3 , D. Mitolo-Chieppa 1<br />
1 Dipartimento <strong>di</strong> Farmacologia e Fisiologia Umana, 2 Dipartimento <strong>di</strong> Anatomia<br />
Patologica e <strong>di</strong> Genetica, 3 Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Interna e Me<strong>di</strong>c<strong>in</strong>a Pubblica,<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Bari, Italy<br />
ON HOMEOSTATIC MECHANISMS OF HIV-PROTEASE INHIBITORS: THEIR<br />
ROLE IN REGULATING MITOCHONDRIAL ACTIVITY AND APOPTOSIS<br />
PRONENESS IN ACTIVATED T LYMPHOCYTES<br />
Matarrese P., Gambardella L., R. Cauda 1 , W. Malori<br />
Departments of Ultrastructure, Istituto Superiore <strong>di</strong> Sanitá - Rome, Italy, and 1<br />
Department of Infectious Diseases, Catholic University, Rome, Italy<br />
SENSITIZATION OF COLON CARCINOMA CELLS TO THYMIDILATE<br />
SYNTHASE AND CARCINO-EMBRYONIC ANTIGEN (CEA)-SPECIFIC<br />
CYTOTOXIC T LYMPHOCYTES BY 5-FLUOROURACIL<br />
1 Correale P, 2 Micheli L, 4 Aqu<strong>in</strong>o A, 4 Giuliani A, 3 Cusi MG, 2 Nenc<strong>in</strong>i C, 4 Prete SP,<br />
4 De Vecchis L, 4 Turriziani M, 1 Franc<strong>in</strong>i G, 4 Bonmassar E, 2 Giorgi G<br />
1 Dip. <strong>di</strong> Patologia Umana ed Oncologia, 2 Dip. <strong>di</strong> Farmacologia-G. Segre, 3 Dip. <strong>di</strong><br />
Biologia Molecolare, <strong>Università</strong> <strong>di</strong> Siena. 4 Dip. <strong>di</strong> Neuroscienze, <strong>Università</strong> <strong>di</strong> Roma,<br />
Tor Vergata<br />
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SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 3A<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia cl<strong>in</strong>ica e farmacosorveglianza.<br />
POSTER 402-420<br />
Moderatore: R. Carretta (Trieste).<br />
Poster<br />
n°<br />
402.<br />
403.<br />
404.<br />
405.<br />
A SIX-YEAR RETROSPECTIVE STUDY OF ADVERSE DRUG REACTIONS TO<br />
ANTIBIOTICS OBSERVED IN TWO PULMONOLOGY DIVISIONS OF<br />
CATANZARO, ITALY.<br />
Gallelli L 1 , Colosimo M 1 , Ferreri G 1 , Pirritano D 1 , Pelaia G 2 , Flocco MA 1 , De<br />
Sarro GB 1<br />
1 Chair of Pharmacology and 2 Chair of Respiratory Diseases, Department of<br />
Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, University “Magna Graecia” of Catanzaro,<br />
Regional Pharmacovigilance Center, “Mater Dom<strong>in</strong>i” University Hospital, Via T.<br />
Campanella, 88100 Catanzaro, Italy<br />
PHARMACOSURVEILLANCE OF ADVERSE DRUG REACTIONS TO<br />
BRONCHODILATORS IN TWO PULMONARY DIVISIONS OF CATANZARO,<br />
ITALY<br />
Gallelli L 1 , Colosimo M 1 , Ferreri G 1 , Pirritano D 1 , Pelaia G 2 , Russo E 1 , De Sarro<br />
GB 1<br />
1 Chair of Pharmacology and 2 Chair of Respiratory Diseases, Department of<br />
Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, University “Magna Graecia” of Catanzaro,<br />
Regional Pharmacovigilance Center, “Mater Dom<strong>in</strong>i” University Hospital, Catanzaro,<br />
Italy<br />
IN A CHRONIC HCV PATIENT INJECTION OF PEGYLATED INTERFERON-<br />
ALFA 2B INDUCED BILATERAL SKIN ULCERATION: PRESENTATION OF A<br />
CASE.<br />
Gallelli L 1 , Guadagn<strong>in</strong>o V 2 , Caroleo B 2 , Marigliano N 1 , De Sarro GB 1<br />
1 Chair of Pharmacology and 2 Chair of Infective Disease, Department of Experimental<br />
and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e, University “Magna Graecia” of Catanzaro, Regional<br />
Pharmacovigilance Center, Via Tommaso Campanella 115, 88100 Catanzaro<br />
CARDIOVASCULAR RISK FACTORS AND UNDERTREATMENT IN<br />
PSYCHIATRIC PATIENTS<br />
Cicero AFG 1 , Vitale G. 2 , Forghieri M. 3 , Poggioli R. 2 , Arletti R. 2<br />
1 2<br />
Atherosclerosis Study Center “G. Descovich”, University of Bologna; Biome<strong>di</strong>cal<br />
Sciences Department, University of Modena and Reggio E.; 3 Neuropsychiatric Health<br />
Care Home “Villa Rosa”, Modena<br />
114<br />
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64<br />
32
Poster<br />
n°<br />
406.<br />
407.<br />
408.<br />
409.<br />
410.<br />
411.<br />
412.<br />
413.<br />
CYP2C9, CYP2C19 AND CYP2D6 GENETIC POLYMORPHISMS AMONG<br />
ITALIANS<br />
Scordo M.G., D’ Arrigo C., Fava G., Sp<strong>in</strong>a E., Caputi A.P.<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology, Section of<br />
Pharmacology, University of Mess<strong>in</strong>a, Italy<br />
GLUTATHIONE RECYCLING AND ANTIOXIDANT ENZYMES IN<br />
ERYTHROCYTES OF NEWBORNS AND HEALTY ADULT<br />
Frosali S., Di Giuseppe D., Di Simplicio P.<br />
University of Siena, Neuroscience Dep., Pharmacology Unit. Siena<br />
KINETICS OF INDOMETHACIN IN HEADACHE PATIENTS WHO<br />
HABITUALLY TAKE OF AN ASSOCIATION OF INDOMETHACIN, CAFFEINE<br />
AND PROCHLORPERAZINE<br />
Ferrari A, Bertol<strong>in</strong>i A, Sav<strong>in</strong>o G, Pasciullo G, Gallesi D, Sances G 1 , Sternieri E<br />
Toxicology and Cl<strong>in</strong>ical Pharmacology Section, Headache Centre, Department of<br />
Internal Me<strong>di</strong>c<strong>in</strong>e. University of Modena and Reggio Emilia; 1 Headache Unit, Irccs C.<br />
Mond<strong>in</strong>o, University of Pavia<br />
PHARMACOEPIDEMIOLOGY OF HEADACHE TREATMENT BEFORE AND<br />
AFTER REFERRAL TO A SPECIALIST CENTRE<br />
Ferrari A, Cicero AFG, Pasciullo G, Ottani A 1 , Sternieri E, Bertol<strong>in</strong>i A.<br />
Headache Centre, Section of Toxicology and Cl<strong>in</strong>ical Pharmacology, Department of<br />
Internal Me<strong>di</strong>c<strong>in</strong>e. 1 Department of Biome<strong>di</strong>cal Sciences Section of Pharmacology;<br />
University of Modena and Reggio Emilia, Italy<br />
NEUTROPHIL DYSFUNCTION IN PATIENTS AFFECTED BY GLYCOGEN<br />
STORAGE DISEASE TYPE 1b. SUBMEMBRANE ALTERATIONS AND EFFECTS<br />
OF GRANULOCYTE COLONY-STIMULATING FACTOR TREATMENT<br />
Elena Lesma, Anna Maria Di Giulio, Alfredo Gorio<br />
Laboratory of Pharmacology, Department of Me<strong>di</strong>c<strong>in</strong>e, Surgery and Dentistry, Faculty<br />
of Me<strong>di</strong>c<strong>in</strong>e, University of Milano, Via Di Rud<strong>in</strong>ì 8, 20142 Milano<br />
NICOTINE EFFECT ON REDOX SYSTEM IN HUMAN FIBROBLASTS<br />
1 Micheli L., 1 Fiaschi A.I., 1 Passarello F., 2 Cozzol<strong>in</strong>o A., 1 Giorgi G.<br />
1 Dipartimento <strong>di</strong> Farmacologia “Giorgio Segre”, 2 Dipartimento <strong>di</strong> Scienze<br />
Odontostomatologiche, <strong>Università</strong> <strong>di</strong> Siena<br />
OCULAR DRUG DELIVERY OF DEXAMETASONE USING SOLID LIPID<br />
NANOPARTICLES<br />
G.P. Zara 1 , R.Cavalli 2 , E. Muntoni 1 , M.R. Gasco 2 , M.F. Saettone 3 , M. Ean<strong>di</strong> 1<br />
1 Department of Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, 2 Department of<br />
Pharmaceutical Science and Technology University of Tor<strong>in</strong>o, and 3 Department of<br />
Biorganic and Biopharmacy University of Pisa<br />
PANCREATITIS INDUCED BY PEGYLATED INTERFERON ALFA-2B IN A<br />
PATIENT AFFECTED BY CHRONIC HEPATITIS C: A CASE-REPORT FROM<br />
THE AZIENDA CAREGGI (FLORENCE)<br />
Cecchi E., Forte P. 2 , C<strong>in</strong>i E. 1 , Banchelli G., Ferlito C., Ten<strong>di</strong> E. 1 , Mugelli A.<br />
For the Pharmacoepidemiology Observatory Dept. of Pharmacology, University of<br />
Florence, 1 Pharmacy Dept. Azienda Careggi, Florence, (Italy); 2 Gastroenterology<br />
Dept. Azienda Careggi, Florence, Italy<br />
115<br />
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128<br />
61<br />
56<br />
55<br />
78<br />
92<br />
147<br />
30
Poster<br />
n°<br />
414.<br />
415.<br />
416.<br />
417.<br />
418.<br />
419.<br />
420.<br />
PARNAPARINA VERSUS ENOXAPARINA IN THE PROPHYLAXIS OF DEEP<br />
VENOUS THROMBOSIS IN ORTHOPAEDIC SURGERY<br />
Manopulo R. 1 , Alfonso C. 1 , Boni S. 1 , Giobbi G. 2 , Puggioli C. 2<br />
Orthopae<strong>di</strong>c Unit 1 , Drug service 2 , S. Orsola-Malpighi Hospital – Bologna (Italy)<br />
PHARMACOKINETIC AND PHARMACOGENETIC DETERMINANTS OF 5-<br />
FLUOROURACIL TOXICITY<br />
Gusella M, Riccio L, Crepal<strong>di</strong> G, Ferrazzi E, Ferrari M 1 , Padr<strong>in</strong>i R 2<br />
Department of Oncology, Rovigo Hospital, Rovigo; 1 Department of Cl<strong>in</strong>ical and<br />
Experimental Me<strong>di</strong>c<strong>in</strong>e, University of Padova, Padova; 2 Department of Pharmacology<br />
and Anesthesiology, University of Padova, Padova<br />
PHARMACOUTILIZATION AND COSTS OF CARDIOVASCULAR DRUGS IN<br />
ITALY: AN HISTORICAL EVALUATION<br />
Licata S., Russo P., Civalleri L., Galasso R., Capr<strong>in</strong>o L.<br />
Dipartimento <strong>di</strong> Fisiologia Umana e Farmacologia, <strong>Università</strong> <strong>di</strong> Roma “La Sapienza”<br />
TDM OF SIROLIMUS IN TRANSPLANTED PATIENTS: AN ITALIAN SURVEY<br />
Brovia D, Gallesi D, Marzocchi N, Bertol<strong>in</strong>i A, P<strong>in</strong>i LA<br />
Cl<strong>in</strong>ical Pharmacology and Toxicology Unit. Dep of Me<strong>di</strong>c<strong>in</strong>e and Me<strong>di</strong>cal Speciality,<br />
University of Modena and Reggio Emilia<br />
TEICOPLANIN PHARMACOKINETICS IN HEMODIALYSIS WAS NOT<br />
AFFECTED BY DIFFERENT ARTIFICIAL MEMBRANES<br />
Migliori M, Filippi C, Origlia N, Mannari C, Panichi V 1 , R<strong>in</strong><strong>di</strong> P 2 , Palla R 3 ,<br />
Giovann<strong>in</strong>i L<br />
Departments of Neuroscience (Pharmacology sect.), and 1 Internal Me<strong>di</strong>c<strong>in</strong>e, University<br />
of Pisa; Divisions of Nephrology, Hospitals of 2 Pisa and 3 Massa, Italy<br />
THE PHARMACOVIGILANCE WEBSITE OF THE AZIENDA CAREGGI<br />
(FLORENCE): AN ATTEMPT TO PROMOTE THE ADVERSE DRUG REACTIONS<br />
(ADRS) REPORTING<br />
Ferlito C., Banchelli G., C<strong>in</strong>i E. 1 , Cecchi E., Ten<strong>di</strong> E. 1 , Mugelli A.<br />
For the Pharmacoepidemiology Observatory (Dept. of Pharmacology, University of<br />
Florence, 1 Pharmacy Dept. Azienda Careggi, Florence, Italy)<br />
THERAPY OPTIMIZATION AND DRUG INTERACTION: DIABETIC THERAPIES<br />
Pantaleoni G., D’ Abramo E.U., Coppol<strong>in</strong>o M.F., Bacchi S., Palumbo G., Sponta<br />
A.M., Di Carlo M., Pantaleoni P.<br />
Chair of Pharmacology, Department of Internal Me<strong>di</strong>c<strong>in</strong>e, University of L’Aquila<br />
116<br />
Abs. book<br />
page<br />
82<br />
73<br />
79<br />
17<br />
93<br />
55<br />
103
SABATO 28 GIUGNO<br />
_______________________________________________________________________AULA 3A<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia cl<strong>in</strong>ica e farmacosorveglianza.<br />
POSTER 421-440<br />
Moderatore: R. Padr<strong>in</strong>i (Padova).<br />
Poster<br />
n°<br />
421.<br />
422.<br />
423.<br />
424.<br />
425.<br />
426.<br />
ASSESSING THE QUALITY AND RELIABILITY OF INFORMATION ON DRUGS<br />
AVAILABLE ON THE INTERNET<br />
Micali A., Polimeni G., Urna G., Caputi A.P.<br />
Dipartimento Cl<strong>in</strong>ico e Sperimentale <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Farmacologia, Sezione <strong>di</strong><br />
Farmacologia, <strong>Università</strong> <strong>di</strong> Mess<strong>in</strong>a<br />
COST OF CARE AND QUALITY OF LIFE IN HEMOPHILIACS DEVELOPING<br />
INHIBITORS AGAINST PRODUCTS OF COAGULATION: THE COCIS STUDY<br />
L Scalone 2 , A Gr<strong>in</strong>geri 1 , PM Mannucci 1 , LG Mantovani 2<br />
1 IRCCS Maggiore Hospital and University of Milan, Milan, Italy; 2 Center of<br />
Pharmacoeconomics, University of Milan, Milan, Italy<br />
COST OF ILLNESS AND QUALITY OF LIFE OF GASTROESOPHAGEAL<br />
REFLUX DISEASE (GERD) PATIENTS IN ITALY<br />
Di Stasi F 1 , Teruzzi C, Monz<strong>in</strong>i MS 1 , Mantovani LG 1<br />
1 Center of Pharmacoeconomics, University of Milan, Milan, Italy; 2 Pharma<br />
Department, Bracco, Milan, Italy<br />
COST-EFFECTIVENESS OF RECOMBINANT VERSUS URINARY FOLLICLE-<br />
STIMULATING HORMONE IN ASSISTED REPRODUCTION TECHNIQUES IN<br />
THE ITALIAN HEALTHCARE SYSTEM<br />
P. Brasseur, L. Gianaroli 1 , G. Ragni 2 , M. Costa 3 , C. De Stefano 4 , A. Beresniak<br />
Serono International, Geneva, Switzerland; 1 SISMER, Bologna, Italy; 2 University of<br />
Milan, Italy; 3 University of Genova, Italy; 4 Assisted Fertilization Center Mercogliano,<br />
Italy<br />
DRUG THERAPEUTIC FAILURES IN EMERGENCY DEPARTMENT PATIENTS.<br />
A NATIONAL UNIVERSITY HOSPITAL EXPERIENCE<br />
Franceschi A., Tuccori M., Bocci G., Vannozzi F., Di Paolo A., Barbara C., Lastella<br />
M., Blan<strong>di</strong>zzi C., Del Tacca M<br />
Interdepartmental Research Center of Cl<strong>in</strong>ical Pharmacology and Experimental<br />
Therapeutics, University of Pisa, Pisa, Italy<br />
DRUG VALUE: EVALUATION OF PHARMACEUTICAL INNOVATION TO<br />
IMPROVE RESEARCH AND DEVELOPMENT<br />
Ravera S., Ceci A., 1 Baiar<strong>di</strong> P., Catapano M., Felisi M., Bell<strong>in</strong>i B.<br />
Consorzio per le Valutazioni Biologiche e Farmacologiche, Pavia (<strong>Università</strong> <strong>degli</strong><br />
<strong>Stu<strong>di</strong></strong> <strong>di</strong> Pavia and 1 Fondazione Salvatore Maugeri)<br />
117<br />
Abs. book<br />
page<br />
92<br />
127<br />
50<br />
16<br />
59<br />
116
Poster<br />
n°<br />
427.<br />
428.<br />
429.<br />
430.<br />
431.<br />
432.<br />
433.<br />
434.<br />
ECONOMIC EVALUATION OF THE AVERT STUDY<br />
PF Ruffo 2 , S Campanella 1 , S Bustacch<strong>in</strong>i 2 , LG Mantovani 1<br />
2 Outcomes Research Unit, Pfizer Italiana Spa, Rome, Italy; 1 Center of<br />
Pharmacoeconomics, University of Milan, Milan, Italy<br />
ECONOMIC EVALUATION OF THE CAPARES STUDY<br />
S Bustacch<strong>in</strong>i 2 , F Rossetti 1 , PF Ruffo 2 , LG Mantovani 1<br />
2 Outcomes Research Unit, Pfizer Italiana Spa, Rome, Italy; 1 Center of<br />
Pharmacoeconomics, University of Milan, Milan, Italy<br />
GENERALIZABILITY OF GUIDELINES AND PHYSICIANS’ ADHERENCE.<br />
CASE STUDY ON THE JNC VI GUIDELINES ON HYPERTENSION<br />
Pedone C, Lapane K.<br />
Centro <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a dell’Invecchiamento – <strong>Università</strong> Cattolica del Sacro Cuore. Rome,<br />
Italy; Center for Gerontology and Health Care Research – Brown University.<br />
Providence, RI, USA<br />
MORE DATABASES FOR THE BIBLIOGRAPHIC INFORMATION RETRIEVAL<br />
IN PHARMACOLOGY<br />
Bianciar<strong>di</strong> L. 1 , Giorgi G. 2<br />
1 C.I.R.D.I.B. – <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena, 2 Dipartimento <strong>di</strong> Farmacologia “Giorgio<br />
Segre”, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena<br />
OPIOID PRESCRIPTION IN THE TREVISO DISTRICT DURING THE TIME<br />
PERIOD 1993-2000<br />
Salvato C 1, 3 , Aret<strong>in</strong>i G 2 , Serraglia D 1 , Terrazzani G 1 , Debetto P 3 , Giusti P 3 ,<br />
Ch<strong>in</strong>ellato A 1<br />
1 Office of Pharmaceutical Service Local Health Authority No. 9 Treviso, 2 General<br />
Practitioner– Local Health Authority No. 9 - Treviso 3 Department of Pharmacology and<br />
Anesthesiology-University of Padova<br />
PHARMACOECONOMIC EVALUATION OF THE PREVENT STUDY<br />
LG Mantovani 1 , S Bustacch<strong>in</strong>i 2 , S De Portu 1 , PF Ruffo 2<br />
1 Center of Pharmacoeconomics, University of Milan, Milan, Italy, 2 Outcomes Research<br />
Unit, Pfizer Italiana Spa, Rome, Italy<br />
PHARMACOSURVEILLANCE IN GENOVA: 1998-2002 DATA<br />
Martelli A., Carrozz<strong>in</strong>o R., Garbero C., Miolo N. 1 , Ferro F. 1<br />
Pharmacology Unit – Department of Internal Me<strong>di</strong>c<strong>in</strong>e (Di.M.I.) – University of<br />
Genova; 1 Pharmacy Unit – AUSL 3 Genovese<br />
PHARMACOUTILIZATION OF STATINS IN PRIMARY CARE: PRELIMINARY<br />
RESULTS OF A CROSS-SECTIONAL ANALYSIS ON A LARGE POPULATION<br />
DATABASE<br />
1 Russo P, 2 Capone A, 2 Degli Esposti L, 2 Buda S, 2 Di Mart<strong>in</strong>o M, 2 Ceccarelli P, 3<br />
Degli Esposti E<br />
1 Department of Human Physiology and Pharmacology, University of Rome “La<br />
Sapienza”, Italy. 2 Clicon S.r.l., Health, Economics, and Outcome Research, Ravenna,<br />
Italy. 3 Local Health Unit 110 of Ravenna, Italy<br />
118<br />
Abs. book<br />
page<br />
121<br />
19<br />
106<br />
12<br />
124<br />
83<br />
85<br />
122
Poster<br />
n°<br />
435.<br />
436.<br />
437.<br />
438.<br />
439.<br />
440.<br />
RESULTS FROM A PHYTOTHERAPY QUESTIONNAIRE AVAILABLE ON THE<br />
INTERNET WEB-SITE WWW.FARMACOVIGILANZA.ORG<br />
Polimeni G. 1 , Russo A. 1 , Iacobelli M. 2 , Cupani C. 1 , Galatti L. 1 , Fava G. 1 ,<br />
Mannucci C. 1 , Catania MA 1 , Calapai G. 1 , Caputi A.P. 1<br />
1 Dipartimento Cl<strong>in</strong>ico e Sperimentale <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Farmacologia, Sezione <strong>di</strong><br />
Farmacologia, <strong>Università</strong> <strong>di</strong> Mess<strong>in</strong>a; 2 Direzione Me<strong>di</strong>ca Gentium S.p.A., Villa<br />
Guar<strong>di</strong>a (CO)<br />
THE PHARMASEARCH NETWORK. A PROJECT OF PHARMACOVIGILANCE<br />
IN ITALY<br />
Polimeni G. 1 , Salvo F. 1 , Russo A. 1 , Fava G. 1 , Galatti L. 1 , Trifirò G. 1 , Cutroneo P. 1<br />
, Giust<strong>in</strong>i E.S. 2 , Sessa A. 2 , Caputi A. P. 1<br />
1 Dipartimento Cl<strong>in</strong>ico e Sperimentale <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Farmacologia, Sezione <strong>di</strong><br />
Farmacologia, <strong>Università</strong> <strong>di</strong> Mess<strong>in</strong>a; 2 Società Italiana <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a Generale (SIMG)<br />
THE ENHANCING EFFECTS OF INTRACELLULAR ASCORBIC ACID ON<br />
PEROXYNITRITE-INDUCED U937 CELL DEATH ARE MEDIATED BY<br />
MITOCHONDRIAL EVENTS RESULTING IN ENHANCED SENSITIVITY TO<br />
PEROXYNITRITE-DEPENDENT INHIBITION OF COMPLEX III AND<br />
FORMATION OF HYDROGEN PEROXIDE<br />
Guidarelli A., 1 Fiorani M. 2 , Cantoni O. 1<br />
1 Istituto <strong>di</strong> Farmacologia e Farmacognosia, Via S. Chiara 27 and 2 Istituto <strong>di</strong> Chimica<br />
Biologica “Giorgio Forna<strong>in</strong>i”, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urb<strong>in</strong>o “Carlo Bo”, Urb<strong>in</strong>o,<br />
Italy<br />
THE RAVENNA CARDIOVASCULAR EVALUATION (RACE) COHORT STUDY:<br />
A LONG-TERM OBSERVATION PERIOD OF TREATMENT WITH STATINS TO<br />
ASSESS PHARMACOUTILIZATION AND EVENTS<br />
Degli Esposti L, Di Mart<strong>in</strong>o M, Capone A, 1 Russo P, Buda S, Saragoni S, 2 Degli<br />
Esposti E<br />
Clicon S.r.l., Health, Economics, and Outcome Research, Ravenna. 1 Department of<br />
Human Physiology and Pharmacology, University of Rome “La Sapienza”. 2 Local<br />
Health Unit 110 of Ravenna<br />
THE ROLE OF COMMUNICATION IN THE PEDIATRICIAN-PARENTS<br />
RELATIONSHIP: A BETTER COMMUNICATION FOR A BETTER<br />
PRESCRIPTION OF DRUGS<br />
Cuzzol<strong>in</strong> L. 1 , Zaffani S. 1 , Murgia V. 2 , Chiamenti G.P. 2 , Gangemi M. 2 , Meneghelli<br />
G. 2 , Benoni G. 1<br />
1 Department of Me<strong>di</strong>c<strong>in</strong>e & Public Health-Section of Pharmacology, University of<br />
Verona, Italy; 2 CESPER-Center of Research Study and Education of Family<br />
Pe<strong>di</strong>atricians<br />
TREATMENT OF OSTEOARTHRITIS: GENERAL PRACTITIONERS (GPs)<br />
PRESCRIPTIONAL BEHAVIOUR FROM THE ASL 1 CASERTA PANORAMICA<br />
GPs DATABASE<br />
Piacent<strong>in</strong>i N 1 , Arcoraci V 1 , Tari M 2 , Moretti S 2 , D' Ad<strong>di</strong>o F 2 , Del Guerra M 2 , De<br />
Cesare G 2 , Lonardo A 2 , Perone V 2 , Tazza A 2 , Caputi AP 1<br />
1 Dipartimento cl<strong>in</strong>ico e sperimentale <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a e Farmacologia – <strong>Università</strong> <strong>di</strong><br />
Mess<strong>in</strong>a; 2 ASL1 - Caserta<br />
119<br />
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page<br />
112<br />
112<br />
73<br />
42<br />
40<br />
108
SABATO 28 GIUGNO<br />
___________________________________________________________CORRIDOIO II° PIANO<br />
Esposizione dei poster: ore 8.30 - 18.00<br />
Visione e <strong>di</strong>scussione dei poster: ore 14.00 - 16.00<br />
SESSIONE DI POSTER: Farmacologia endocr<strong>in</strong>a e del metabolismo.<br />
POSTER 441-457<br />
Moderatore: C. Galli (Milano).<br />
Poster<br />
n°<br />
441.<br />
442.<br />
443.<br />
444.<br />
445.<br />
ADIPONECTIN DIRECTLY STIMULATES PRODUCTION OF NITRIC OXIDE IN<br />
ENDOTHELIAL CELLS VIA A PI 3-K-DEPENDENT PATHWAY. A NOVEL<br />
ACTION THAT MIGHT ACCOUNT FOR ADIPONECTIN SENSITIZING<br />
PROPERTIES ON VASCULAR ACTIONS OF INSULIN<br />
Monica Montagnani MD 1 , Hui Chen MD 2 , Tohru Funahashi MD 3 , Delia Mitolo<br />
Chieppa MD 1 , Iichiro Shimamura MD 3 , Michael J Quon, MD 2<br />
1 Dept of Pharmacology and Human Physiology, Bari, Italy, 2 NCCAM - National<br />
Institutes of Health, Bethesda, MD and 3 Osaka, Japan<br />
BONE-TURNOVER THERAPY: A NEW SERUM MARKER POTENTIALLY<br />
USEFUL FOR ITS MONITORING<br />
Tamaro G, Guerci V, Ciana G, Bembi B<br />
I.R.C.C.S. Burlo Garofolo-Trieste<br />
CIRCULATING NERVE GROWTH FACTOR CONCENTRATION IS SEXUAL<br />
HORMONE-RELATED AND IT IS INCREASED IN PATIENTS WITH<br />
MICROPROLACTINOMA<br />
Sigala S., Martocchia A. 1 , Falaschi P. 1 , Missale C., Spano P.F.<br />
Section of Pharmacology, Dept. of Biome<strong>di</strong>cal Sciences and Biotechnologies,<br />
University of Brescia Me<strong>di</strong>cal School, Brescia; 1 Chair of Internal Me<strong>di</strong>c<strong>in</strong>e, II Faculty<br />
of Me<strong>di</strong>c<strong>in</strong>e, University of Roma La Sapienza, Roma<br />
DIFFERENT INTRACELLULAR PATHWAYS MEDIATE SOMATOSTATIN<br />
INHIBITION OF DNA SYNTHESIS AND GH RELEASE FROM DISPERSED<br />
HUMAN GH-SECRETING PITUITARY ADENOMA CELLS<br />
Diana F. 1 , Thellung S. 1 , Corsaro A. 1 , Arena S. 1 , Pattarozzi A. 1 , Schett<strong>in</strong>i G. 1 , 2 ,<br />
1 , 2<br />
Florio T.<br />
1 2<br />
Sect. of Pharmacology Dept. Oncology Biology and Genetics, University of Genova,<br />
Pharmacology and Neuroscience, National Institute for Cancer Research (IST) Largo R.<br />
Benzi 10, 16132 Genova, Italy<br />
A NEW LOW DOSE SOY PROTEIN/_-SITOSTEROL ASSOCIATION<br />
SIGNIFICANTLY REDUCES PLASMA LDL-C LEVELS VERSUS BASELINE<br />
LDL-C CONCENTRATIONS<br />
Cicero AFG., Monica M<strong>in</strong>ar<strong>di</strong>, Egi<strong>di</strong>o Pedro, Z<strong>in</strong>a Sangiorgi, Antonio Gad<strong>di</strong><br />
Atherosclerosis and Dysmetabolic Diseases Study Centre “G. Descovich”- Cl<strong>in</strong>ical<br />
Me<strong>di</strong>c<strong>in</strong>e and Applied Biotechnology “D. Campanacci” - University of Bologna - Italy<br />
120<br />
Abs. book<br />
page<br />
95<br />
135<br />
129<br />
46<br />
33
Poster<br />
n°<br />
446.<br />
447.<br />
448.<br />
449.<br />
450.<br />
451.<br />
452.<br />
DOES A DIETARY PSYLLIUM SUPPLEMENTATION IMPROVE GLYCAEMIA<br />
AND LIPOPROTEINEMIA CONTROL IN ELDERLY SUBJECTS AFFECTED BY<br />
X-METABOLIC SYNDROME? A PRELIMINARY OPEN TRIAL<br />
Cicero AFG 1 , Derosa G 2<br />
1 Atherosclerosis Study Centre “GC Descovich” – Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Applied<br />
Biotechnology Dept. “D. Campanacci” – University of Bologna; 2 Department of<br />
Internal Me<strong>di</strong>c<strong>in</strong>e and Therapeutics, University of Pavia, Italy<br />
HERBAL MEDICINES SUGGESTED BY ITALIAN HERBALISTS TO IMPROVE<br />
BLOOD PRESSURE VALUES, CHOLESTEROLEMIA AND GLYCAEMIA: LEVEL<br />
OF SCIENTIFIC EVIDENCE AND RISKS<br />
Cicero AFG, Maria P Panourgia, Maria Scurti, Simona Nascetti, Antonio Gad<strong>di</strong><br />
Atherosclerosis Research Centre “G. Descovich” - Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Applied<br />
Biotechonology Dept. - University of Bologna, Italy<br />
ESTROGEN REGULATION OF HUMAN LACRIMAL FLUID PEROXIDASE<br />
ACTIVITY<br />
Liberati V. 1 , Rossi F. 1 , Pizz<strong>in</strong>ga A. 1 , de Feo G. 1 , Botrè F. 2 , Marcozzi G. 3<br />
1 Dip. Farmacologia delle Sostanze Naturali e Fisiologia Generale, <strong>Università</strong> <strong>di</strong> Roma<br />
“La Sapienza”; 2 Laboratorio Antidop<strong>in</strong>g FMSI, Roma; 3 Dip. Biologia <strong>di</strong> Base ed<br />
Applicata, <strong>Università</strong> de L’Aquila<br />
GLUCOCORTICOID RESISTANCE IN PATIENTS WITH AUTOIMMUNE<br />
DISEASE<br />
Drigo I. 1 , 2 , Bacch<strong>in</strong> C. 1 , Rosati A. 1 , Bartoli F. 1 , Decorti G. 1 , Candussio. L. 1 , Barbi<br />
E. 2 , Ventura A. 2 , Giral<strong>di</strong> T. 1<br />
1 Biome<strong>di</strong>cal Sciences Department, University of Trieste; 2 I.R.C.C.S Burlo Garofolo<br />
Trieste<br />
HYPOTHALAMIC-PITUITARY-GONADAL AXIS ALTERATIONS: EFFECTS ON<br />
LIPID AND DNA OXIDATIVE DAMAGE IN HIPPOCAMPUS AND CORTEX OF<br />
MALE AND FEMALE RATS<br />
Marzatico F., Pansarasa O., Marzani B., Branciforte D., Barulli D.<br />
Department of Physiological and Pharmacological Cellular and Molecular Sciences;<br />
Section of Pharmacology and Pharmacological Biotechnologies; University of Pavia;<br />
P.zza Botta 11, 27100 Pavia (Italy)<br />
LEVONORGESTREL-INDUCED CHANGES IN BRAIN CONCENTRATIONS OF<br />
NEUROSTEROIDS, GABAA RECEPTOR GENE EXPRESSION AND BEHAVIOR<br />
Sogliano, C., Porcu, P., Mostall<strong>in</strong>o M.C., Ibba C., Piredda, M., Tocco S., Biggio G.,<br />
Concas, A.<br />
Department of Experimental Biology, University of Cagliari, Cagliari, Italy<br />
MAINTENANCE OF A NORMAL MEAL-INDUCED DECREASE OF PLASMA<br />
GHRELIN LEVELS IN CHILDREN WITH PRADER-WILLI SYNDROME:<br />
COMPARISON WITH NORMAL AND OBESE CHILDREN<br />
Antonello E Rigamonti, Marco Cappa 1 , Carla Bizzarri 1 , Eugenio E Muller, Silvano<br />
G Cella<br />
Department of Me<strong>di</strong>cal Pharmacology, University of Milan, Milan, Italy; 1 Pe<strong>di</strong>atric<br />
and Adolescent Unit, Bamb<strong>in</strong>o Gesù, IRCCS, Palidoro, Rome<br />
121<br />
Abs. book<br />
page<br />
32<br />
33<br />
79<br />
52<br />
86<br />
130<br />
118
Poster<br />
n°<br />
453.<br />
454.<br />
455.<br />
456.<br />
457.<br />
NEW STABLE FORMULATION OF LONG CHAIN N-3 POLYUNSATURATED<br />
FATTY ACIDS (PUFA). PREVENTIVE EFFECT ON EXPERIMENTAL DIABETIC<br />
NEUROPATHY<br />
Bernasconi R., Bianchi R., Galliani G., Sav<strong>in</strong>o C., Tacconi MT.<br />
Istituto <strong>di</strong> Ricerche Farmacologiche Mario Negri, Milano<br />
NITRIC OXIDE (NO)-RELEASING PROPERTIES OF HCT 1026, A DERIVATIVE<br />
OF FLURBIPROFEN: IN VITRO AND IN VIVO STUDIES BY EPR<br />
SPECTROSCOPY IN RATS<br />
Monopoli A., Govoni M., Presotto C., Ong<strong>in</strong>i E., Maucci R.<br />
Nicox Research Institute, Bresso, Milan<br />
PLASMA OSTEOPROTEGERIN LEVELS IN NORMAL CHILDREN AND IN<br />
CHILDREN WITH DIFFERENT DISEASES<br />
Maccar<strong>in</strong>elli G., Ruggeri F., 1 Guaragni B., 1 Buzi F, Cocchi D.<br />
Dept. Biomed. Sci. & Biotech., University of Brescia, 1 Dept. of Pe<strong>di</strong>atrics, Spedali<br />
Civili, Brescia<br />
POST-NATAL REPEATED MILD STRESS INDUCE DISRUPTIVE REGULATION<br />
OF HPA HORMONES BALANCE IN THE ADULT LIFE<br />
Galietta G., Capasso A., De Iovanna M.A., Campana G., Spamp<strong>in</strong>ato S., Fortuna A.,<br />
Loizzo S., Loizzo A.<br />
Istituto Superiore <strong>di</strong> Sanità, Roma; <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Salerno; <strong>Università</strong> <strong>degli</strong><br />
stu<strong>di</strong> <strong>di</strong> Bologna<br />
SALICYLIC ACID: EFFECT IN HYPERGLYCAEMIC RATS<br />
De Francia S., Ghezzo F., Pirro E., Cesano L., Mognetti B., Chiarpotto E., Poli G., Di<br />
Carlo F.<br />
Dipartimento <strong>di</strong> Scienze Cl<strong>in</strong>iche e Biologiche, <strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o<br />
122<br />
Abs. book<br />
page<br />
10<br />
95<br />
80<br />
62<br />
41
DOMENICA 29 GIUGNO<br />
__________________________________________________________________AULA MAGNA<br />
Ore 8.30 – 10.30<br />
MINISIMPOSIO: Meccanismi molecolari e cellulari del danno cerebrale ischemico: nuove<br />
prospettive terapeutiche.<br />
Moderatori: L. Annunziato (Napoli) - F. Moroni (Firenze)<br />
8.30 L’aumento dell’espressione del HIF-1_ <strong>in</strong>dotto dall’ischemia cerebrale è associato alla sua<br />
attività <strong>di</strong> b<strong>in</strong>d<strong>in</strong>g sul promotore del gene co<strong>di</strong>ficante la iNOS.<br />
C. Matrone (Napoli)<br />
8.50 Ruolo delle MAGUK nella vulnerabilità neuronale.<br />
F. Gardoni (Milano)<br />
9.10 I fattori p65 e cRel appartenenti alla famiglia NF-kB: due opposti regolatori della<br />
vulnerabilità neuronale all’ischemia.<br />
M. Pizzi (Brescia)<br />
9.30 Meccanismi molecolari e cellulari della plasticità s<strong>in</strong>aptica post-ischemica nello striato <strong>di</strong><br />
mammifero.<br />
E. Saulle (Roma)<br />
9.50 La poli (ADB-Ribosio) polimerasi: un importante bersaglio farmacologico nella terapia<br />
dell’ischemia cerebrale.<br />
A. Chiarugi, E. Meli, A. Cozzi, D. Pellegr<strong>in</strong>i-Giampietro, F. Moroni (Firenze)<br />
123
DOMENICA 29 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 8.30 – 10.30<br />
SESSIONE DI COMUNICAZIONI ORALI: Tossicologia<br />
Moderatori: G. Cantelli Forti (Bologna) - A. Gullo (Trieste)<br />
In collaborazione con la Società Italiana <strong>di</strong> Tossicologia<br />
Ore Abs. book<br />
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8.30 INFLAMMATORY CYTOKINES AND TOLL-LIKE RECEPTOR-4 GENE<br />
EXPRESSION IN THE MURINE LIVER AFTER CHRONIC EXPOSURE TO<br />
ALCOHOL: EFFECTS OF LIPID PEROXIDATION INHIBITION<br />
Altavilla D, Sem<strong>in</strong>ara P, Calapai G, M<strong>in</strong>utoli L, Passaniti M, Mar<strong>in</strong>i H, Caputi AP,<br />
Squadrito F<br />
Department of Experimental and Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Pharmacology University of<br />
Mess<strong>in</strong>a, Italy<br />
8.45 ARE ALL GENOTOXIC CARCINOGENS DETECTED BY THE STANDARD<br />
BATTERY OF GENOTOXICITY TESTS?<br />
Robbiano L., Baroni D., Taramasco R., Brambilla G.<br />
Pharmacology and Toxicology Unit – Deparment of Internal Me<strong>di</strong>c<strong>in</strong>e (Di.M.I.) –<br />
University of Genoa<br />
9.00 FERRYLMYOGLOBIN-DEPENDENT OXIDATIVE DEGRADATION OF<br />
DOXORUBICIN: A NOVEL PATHWAY OF ANTHRACYCLINE METABOLISM<br />
AND TOXICITY<br />
Menna P, Salvatorelli E, ** Braghiroli D, Giampietro R, *Cartoni A, *Animati F,<br />
M<strong>in</strong>otti G<br />
Center of Excellence on Ag<strong>in</strong>g and Department of Drug Sciences, G. d’Annunzio<br />
University Schools of Me<strong>di</strong>c<strong>in</strong>e and ** Pharmacy, Chieti; *Department of Chemistry,<br />
Menar<strong>in</strong>i Ricerche S.p.A., Pomezia (Rome)<br />
9.15 BENZO(A)PYRENE DIOLEPOXIDE-DNA ADDUCT LEVELS IN WHITE<br />
BLOOD CELLS FROM SMOKERS: RELATION TO CYP1A1, GSTM1, GSTP1,<br />
GSTT1 AND MEH POLYMORPHISMS<br />
Francesco Guglielmi, Maura Lodovici, Crist<strong>in</strong>a Luceri, Chiara Bacci, Clau<strong>di</strong>o<br />
Evangelisti, Victor Akpan, Piero Dolara<br />
Department of Pharmacology, University of Florence, Viale Pieracc<strong>in</strong>i 6, 50139,<br />
Florence<br />
9.30 GENOTOXIC EFFECTS OF SHIGA TOXIN 1 AND RICIN IN CULTURED<br />
HUMAN ENDOTHELIAL CELLS<br />
Sestili 1 P., Brigotti 2 M., Carnicelli 2 D., Barbieri 2 L., Stirpe 2 F., Guidarelli 1 A.,<br />
Alfieri 3 R., Petron<strong>in</strong>i 3 P.G<br />
1 Istituto <strong>di</strong> Farmacologia e Farmacognosia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Urb<strong>in</strong>o “Carlo<br />
Bo”, Urb<strong>in</strong>o, Italy 2 Dipartimento <strong>di</strong> Patologia sperimentale, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong><br />
Bologna, Bologna, Italy 3 Dipartimento <strong>di</strong> Me<strong>di</strong>c<strong>in</strong>a sperimentale, Sezione <strong>di</strong><br />
Patologia molecolare e Immunologia, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Parma, Urb<strong>in</strong>o, Italy<br />
124<br />
2<br />
119<br />
91<br />
73<br />
129
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9.45 EFFECT OF AN ORAL CHRONIC PHYTOESTROGEN SUPPLEMENTATION<br />
ON MALE RAT SEXUAL PERFORMANCES AND SEXUAL HORMONE<br />
PLASMA LEVELS<br />
Arrigo FG Cicero °, Giovanni Vitale*, Rossana Arletti*<br />
°Atherosclerosis Research Centre “G. Descovich” - Cl<strong>in</strong>ical Me<strong>di</strong>c<strong>in</strong>e and Applied<br />
Biotechonology Dept.-University of Bologna, Italy;*Biome<strong>di</strong>cal Sciences Dept.,<br />
Pharmacology Section, University of Modena and Reggio nell’Emilia, Italy<br />
10.00 OXCARBAZEPINE ACUTE INTOXICATION<br />
Franceschi L.*; Milanese M.**; Silvestri L.**; Pecorari M.; *** Furlanut M.*<br />
*Institute of Cl<strong>in</strong>ical Pharmacology and Toxicology, DPMSC, University of Ud<strong>in</strong>e;<br />
** Intensive Care Unit and ***Dialysis Unit, ASS2 Isont<strong>in</strong>a, Gorizia<br />
10.15 RECEPTOR INTERACTIONS AND BEHAVIORAL DEFICIENCIES IN RATS<br />
TREATED WITH NEUROTOXIC DOSES OF DISULFIRAM<br />
Barone D., Rolfo K., Yu P., Oberto G. , Funicello M.*, Mereghetti I.*, Cagnotto A.*,<br />
Menn<strong>in</strong>i T.*<br />
Istituto <strong>di</strong> Ricerche Biome<strong>di</strong>che “A. Marxer” RBM SpA, Via Ribes, 1; 10010 -<br />
Colleretto Giacosa (TO) Italy; *Istituto <strong>di</strong> Ricerche Farmacologiche Mario Negri, Via<br />
Eritrea, 62; 20157 - Milano, Italy<br />
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DOMENICA 29 GIUGNO<br />
_______________________________________________________________________AULA I A<br />
Ore 8.30 – 10.30<br />
MINISIMPOSIO: Determ<strong>in</strong>anti genetici e molecolari della risposta <strong>in</strong><strong>di</strong>viduale agli <strong>in</strong>ibitori delle<br />
ciclo-ossigenasi.<br />
Moderatori: C. Patrono (Roma) – M. Del Tacca (Pisa)<br />
8.30 Inibizione della COX-1 piastr<strong>in</strong>ica da parte dell’aspir<strong>in</strong>a: meccanismi alla base <strong>di</strong> fenomeni<br />
<strong>di</strong> “resistenza”.<br />
B. Rocca (Roma)<br />
9.00 Variabilità farmacoc<strong>in</strong>etica/farmacod<strong>in</strong>amica nella risposta <strong>in</strong><strong>di</strong>viduale agli <strong>in</strong>ibitori<br />
selettivi della COX-2.<br />
P. Patrignani (Chieti)<br />
9.30 Platelet COX-1 activity is a major determ<strong>in</strong>ant of the vascular effects of selective COX-2<br />
<strong>in</strong>hibitors.<br />
G.A. FitzGerald (Philadelphia, PA)<br />
10.00 Le conseguenze funzionali dell’espressione ed <strong>in</strong>ibizione della COX-2 sono modulate dalla<br />
variabile espressione <strong>di</strong> enzimi a monte e a valle della COX-2.<br />
F. Cipollone (Chieti)<br />
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_______________________________________________________________________AULA 1B<br />
Ore 8.30 – 10.30<br />
SESSIONE DI COMUNICAZIONI ORALI: Chemioterapia III<br />
Moderatori: S. Vella (Roma) - G. Cartei (Padova)<br />
Ore Abs. book<br />
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8.30 PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES SENSITIZE MELANOMA<br />
CELLS TO THE CHEMOTHERAPIC DRUGS: TAXOL AND VINDESINE<br />
1 Merighi S, 2 Mirandola P, 1 Varani K, 1 Gessi S, 3 Leung E, 4 Baral<strong>di</strong> PG, 4 Tabrizi<br />
MA, 1 Avitabile A, 1 Cattabriga E, 1 Iannotta V, 1 Pancal<strong>di</strong> C, 1 Borea PA<br />
1 Dept. of Cl. & Exp. Med., Pharmacology Unit; Univ. of Ferrara, 44100, Ferrara,<br />
Italy; 2 Dept. of Human Anatomy, Pharmacology and Forensic Me<strong>di</strong>c<strong>in</strong>e, Institute of<br />
Normal Human Anatomy, Univ. of Parma, 43100, Parma, Italy; 3 K<strong>in</strong>g<br />
Pharmaceuticals, 27513, Cary, NC, U.S.A.; 4 Dept of Pharmaceutical Sciences; Univ.<br />
of Ferrara, 44100, Ferrara, Italy<br />
8.45 INVOLVEMENT OF NEUROKININ-1 RECEPTOR IN PROSTATE CANCER<br />
DEVELOPMENT<br />
Pompei, P. a , Martarelli, B., b Martarelli, D., a Pe<strong>di</strong>coni. D., a Nabissi, M. c<br />
a Department of Pharmacological Sciences and Experimental Me<strong>di</strong>c<strong>in</strong>e, University of<br />
Camer<strong>in</strong>o, 62032 Camer<strong>in</strong>o, Italy - b Department of Morphological Sciences and<br />
Comparative Biochemistry, 62032 Camer<strong>in</strong>o, Italy - c Biosistema S.r.l., 62032<br />
Camer<strong>in</strong>o, Italy<br />
9.00 THE ANTIPROLIFERATIVE EFFECT OF SOMATOSTATIN IN HUMAN<br />
COLON CANCER CELLS IS MEDIATED BY DOWNREGULATION OF COX-2<br />
EXPRESSION<br />
Colucci R., Blan<strong>di</strong>zzi C., Tan<strong>in</strong>i M., Ghisu N., Breschi M.C., Del Tacca M.<br />
Interdepartmental Research Center of Cl<strong>in</strong>ical Pharmacology and Experimental<br />
Therapeutics, University of Pisa, Pisa, Italy<br />
9.15 SALICYLATES DOSE DEPENDENT INHIBITION OF CHEMICALLY<br />
INDUCED RAT MAMMARY TUMORS: EFFECT ON ANGIOGENESIS AND<br />
CONCOMITANCE OF MISOPROSTOL ADMINISTRATION<br />
Ghezzo F, Cesano L, Pirro E, Mognetti B, Berta G, Z<strong>in</strong>garo B, Pesce E, Corvetti G,<br />
Di Carlo F<br />
Dipartimento <strong>di</strong> Scienze Cl<strong>in</strong>iche e Biologiche dell’<strong>Università</strong> <strong>di</strong> Tor<strong>in</strong>o & Ospedale<br />
S.Luigi, Orbassano<br />
9.30 ANTINEOPLASTIC EFFECTS OF SU5416, A NOVEL VASCULAR<br />
ENDOTHELIAL GROWTH FACTOR PATHWAY INHIBITOR, IN AN ORAL<br />
CANCER ANIMAL MODEL<br />
Berta GN, Giai Pron R, Ghezzo F, Mognetti B, Corvetti G, Limonciello V, E Pirro, E<br />
Trione, F Di Carlo<br />
Department of Biological and Cl<strong>in</strong>ical Sciences, University of Tur<strong>in</strong>, Italy<br />
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112<br />
35<br />
67<br />
11
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9.45 INHIBITION OF LIVER TUMOR LESIONS BY HA-BUT, A NOVEL HISTONE<br />
DEACETYLASE INHIBITOR BIOCONJUGATE<br />
S. Zorzet 1 , D. Corad<strong>in</strong>i 2 , R. Ross<strong>in</strong> 3 , C. Turr<strong>in</strong> 1 ,4 , C. Casarsa 4 , G. Sava 1 ,4 , C.<br />
Pellizzaro 2 , M.G. Daidone 2 , U. Mazzi 3 , A. Perbell<strong>in</strong>i 5<br />
1 Department of Biome<strong>di</strong>cal science, University of Trieste; 2 Department of<br />
Experimental Oncology, Unit 10, Istituto Nazionale per lo <strong>Stu<strong>di</strong></strong>o e la Cura dei<br />
Tumori, Milan; 3 Department of Pharmaceutical Science, University of Padua, 4<br />
Fondazione Callerio-Onlus, Trieste; 5 COIMEX s.c.r.l., Reggio Emilia, Italy<br />
10.00 MODULATION OF CD44 IN TUMOUR CELLS AND IN LYMPHOCYTES<br />
CORRELATES WITH ANTIMETASTATIC ACTIVITY OF NAMI-A AFTER<br />
INTRATUMOR TREATMENT<br />
Pacor S. * , Zorzet S., Cocchietto M. ^, Bacac M., Vadori M. , Turr<strong>in</strong> C. Gava B.,<br />
Castellar<strong>in</strong> A., Sava G<br />
Department of Biome<strong>di</strong>cal Sciences and ^Fondazione C.&D: Callerio, University of<br />
Trieste, Trieste, Italy<br />
10.15 PROGRESSI E PROSPETTIVE FUTURE DELLA FARMACOLOGIA E DELLA<br />
TERAPIA DELL’INFEZIONE DA HIV.<br />
S. Vella.<br />
Istituto Superiore <strong>di</strong> Sanità, Roma.<br />
128<br />
147<br />
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__________________________________________________________________AULA MAGNA<br />
Ore 11.00 – 13.00<br />
MINISIMPOSIO: Analogie molecolari nei processi <strong>di</strong> sviluppo neuronale e <strong>di</strong><br />
neurodegenerazione: nuove prospettive farmacologiche?<br />
Moderatori: P.L. Canonico (Novara) - M. Memo (Brescia)<br />
11.00 Notch2 nei processi <strong>di</strong> <strong>di</strong>fferenziamento e morte neuronale.<br />
M. Memo (Brescia)<br />
11.20 Ruolo <strong>di</strong> Reel<strong>in</strong> nella s<strong>in</strong>aptogenesi e nella plasticità s<strong>in</strong>aptica.<br />
F. Keller (Roma)<br />
11.40 Co<strong>in</strong>volgimento della tiros<strong>in</strong>a-ch<strong>in</strong>asi non recettoriale Fps/Fes nel <strong>di</strong>fferenziamento e<br />
degenerazione neuronale.<br />
F. Condorelli (Novara)<br />
12.00 ß-amiloide e DNA polimerasi neuronali.<br />
A. Copani (Catania)<br />
12.20 Interazioni tra APP e prote<strong>in</strong>e adattatrici nei processi <strong>di</strong> neurosviluppo e<br />
neurodegenerazione.<br />
G. Schett<strong>in</strong>i (Genova)<br />
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DOMENICA 29 GIUGNO<br />
_______________________________________________________________________AULA 0B<br />
Ore 11.00 – 13.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Farmacologia car<strong>di</strong>ovascolare II<br />
Moderatori: S. Luciani (Padova) – M. Ziche (Siena)<br />
Ore Abs. book<br />
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11.00 ROLE OF MAST CELL SECRETORY GRANULES IN ANGIOGENESIS<br />
Teresa Iuvone, Manuela Peticca, * Annap<strong>in</strong>a Russo, *Giulia Russo, Pasquale<br />
Maffia, *Concetta Pietropaolo, Massimo Di Rosa<br />
Dipartimento <strong>di</strong> Farmacologia Sperimentale, Via D. Montesano 49 e *Dipartimento<br />
<strong>di</strong> Biochimica e Biotecnologie Me<strong>di</strong>che, Via Pans<strong>in</strong>i 5, <strong>Università</strong> <strong>di</strong> Napoli<br />
“Federico II”<br />
11.15 NONLIPID-RELATED EFFECTS OF ATORVASTATIN ON COLLAR-INDUCED<br />
CAROTID LESION COMPOSITION IN CHOLESTEROL-FED RABBITS<br />
Baetta R 1 , Comparato C 1 , Donetti E 2 , Bosch<strong>in</strong>i E 2 , Silva F 1 , Cors<strong>in</strong>i A 1<br />
1 Dipartimento <strong>di</strong> Scienze Farmacologiche e 2 Dipartimento <strong>di</strong> Anatomia Umana,<br />
<strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Milano, Milano<br />
11.30 ANGIOSUPPRESSIVE AND ANGIOSTIMULATORY EFFECTS EXERTED BY<br />
SYNTHETIC PARTIAL SEQUENCES OF ENDOSTATIN<br />
Morbidelli L., Donn<strong>in</strong>i S., Calvani M., Cantara S., Ferrara P., Ziche M.<br />
Pharmacology Section, Dept. Molecular Biology, University of Siena, Via A. Moro 2,<br />
53100 Siena, Italy<br />
11.45 A MOLECULAR BASIS FOR HCN CHANNEL OVER-EXPRESSION IN<br />
MYOCARDIAL HYPERTROPHY: A STUDY IN CULTURED ADULT RAT<br />
CARDIOMYOCYTES<br />
Stillitano F., DePaoli P., Sartiani L., Paola R., Mugelli A., Cerbai E.<br />
Department of Pharmacology, University of Florence, Florence, Italy<br />
12.00 ABC TRANSPORTERS AND APO-E PROMOTE MACROPHAGE<br />
CHOLESTEROL EFFLUX IN THE ABSENCE OF EXTRACELLULAR<br />
ACCEPTORS<br />
Cignarella A, 1 Engel T, 2 Von Eckardste<strong>in</strong> A, 3 Cullen P, 2 Assmann G. 2<br />
1 2<br />
Department of Pharmacological Sciences, University of Milan, Italy; Institute of<br />
Arteriosclerosis Research, University of Münster, Germany; 3 Institute of Cl<strong>in</strong>ical<br />
Chemistry, University of Zurich, Switzerland<br />
12.15 SYNTHETIC HIGH DENSITY LIPOPROTEINS PROTECT THE HEART<br />
AGAINST ISCHEMIA-REPERFUSION INJURY<br />
L. Calabresi, G. Rossoni, M. Gomaraschi, C.R. Sirtori, G. Francesch<strong>in</strong>i<br />
Center E. Grossi Paoletti, Department of Pharmacological Sciences, University of<br />
Milano, Italy<br />
130<br />
75<br />
5<br />
96<br />
133<br />
34<br />
19
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12.30 CALPAIN INHIBITOR I REDUCES ISCHAEMIA AND REPERFUSION-<br />
INDUCED INTESTINAL INJURY<br />
1 Marzocco S., 2 DiPaola R. 1 Autore G., 2 Serra<strong>in</strong>o I., 2 De Sarro A., 1 P<strong>in</strong>to A. 2<br />
Caputi A.P., 2 Cuzzocrea S.<br />
1 Dept. of Pharmaceutical Science, University of Salerno, Italy. 2 Institute of<br />
Pharmacology, University of Mess<strong>in</strong>a, Italy<br />
12.45 ENDOTHELIN SYSTEM IMPAIREMENT IN STREPTOZOTOCIN INDUCED<br />
DIABETES IN NORMOTENSIVE AND SPONTANEOUS HYPERTENSIVE<br />
RATS<br />
Mattera G.G., Botarelli M., Pacifici L., Carm<strong>in</strong>ati P.<br />
General Pharmacology Dept, R&D Sigma Tau SpA, Pomezia Italy<br />
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_______________________________________________________________________AULA I A<br />
Ore 11.00 – 13.00<br />
MINISIMPOSIO: Farmacoeconomia<br />
Moderatori: A. Ceci (Bari) - L. Capr<strong>in</strong>o (Roma)<br />
11.00 Gestione del rischio car<strong>di</strong>ovascolare globale: aspetti farmacoeconomici.<br />
L.G. Mantovani (Milano)<br />
11.15 Farmacoeconomia e me<strong>di</strong>c<strong>in</strong>a generale.<br />
O. Brignoli (Brescia)<br />
11.30 La farmacoepidemiologia: uno strumento per il governo cl<strong>in</strong>ico.<br />
E. Degli Esposti (Ravenna)<br />
11.45 L’approccio epidemiologico <strong>in</strong> farmacoeconomia per la valutazione <strong>di</strong> esito cl<strong>in</strong>ico ed<br />
economico.<br />
P. Russo (Roma)<br />
12.00 Farmacoeconomia della terapia antibiotica.<br />
C. Della Pepa (Tor<strong>in</strong>o)<br />
12.15 Farmacoeconomia dei fattori della coagulazione.<br />
A. Gr<strong>in</strong>geri (Milano)<br />
12.30 L<strong>in</strong>ee-guida “costo-efficacia”per l’utilizzo <strong>degli</strong> <strong>in</strong>ibitori della pompa protonica.<br />
A. Ceci (Bari)<br />
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_______________________________________________________________________AULA 1B<br />
Ore 11.00 – 13.00<br />
SESSIONE DI COMUNICAZIONI ORALI: Farmacologia dell’<strong>in</strong>fiammazione<br />
Moderatori: F. Franconi (Sassari) – P. Patrignani (Chieti)<br />
Ore Abs. book<br />
page<br />
11.00 ATP-MEDIATED ROCK I-DEPENDENT BLEB FORMATION IN P2X7<br />
EXPRESSING HEK293 CELLS<br />
Ferrari D, Morelli A, Chiozzi P, Chiesa A, Sanz JM, Falzoni S, Pizzirani C, P<strong>in</strong>ton<br />
P, Rizzuto R, Olson MF, Di Virgilio F<br />
Dept. of Exp. and Diagn. Me<strong>di</strong>c<strong>in</strong>e, Sect. of General Pathology, and Interd. Center<br />
for the Study of Inflammation (ICSI), University of Ferrara, Italy; Abramson Family<br />
Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA<br />
11.15 THE ADHESION OF NEUTROPHILS TO ENDOTHELIAL CELLS EVOKED BY<br />
SUBSTANCE P: EFFECTS OF COX-2 INHIBITORS<br />
Coll<strong>in</strong>o M., Gallicchio M., Dianzani C., Fantozzi R.<br />
Dip. Anatomia, Farmacologia e Me<strong>di</strong>c<strong>in</strong>a Legale, Univ. Tor<strong>in</strong>o<br />
11.30 ENDOGENOUS PROSTAGLANDIN E2 DOES NOT MODULATE<br />
INTERLEUKIN-1b BIOSYNTHESIS IN HUMAN WHOLE BLOOD<br />
Grana M., Ricciotti E., Sciulli M.G., § Pistritto G., Patrignani P.<br />
Department of Me<strong>di</strong>c<strong>in</strong>e & Ag<strong>in</strong>g ,“G. D’Annunzio” University, Chieti, and § ”Tor<br />
Vergata” University, Rome, Italy<br />
11.45 EFFECTS OF SILYMARIN ON CEREBRAL OXIDATIVE STRESS IN RAT<br />
INDUCED BY ACETAMINOPHEN<br />
Micheli L., Nenc<strong>in</strong>i C., Cerretani D., Fiaschi A.I., Giorgi G.<br />
Dipartimento <strong>di</strong> Farmacologia “Giorgio Segre”, <strong>Università</strong> <strong>degli</strong> <strong>Stu<strong>di</strong></strong> <strong>di</strong> Siena<br />
12.00 ANTINOCICEPTIVE ACTIVITY OF THE NOVEL NMDA ANTAGONIST<br />
CHF3381 IN MODELS OF INFLAMMATORY AND NEUROPATHIC PAIN<br />
Villetti G 1 , Bergamaschi M 1 , Bassani F 1 , Bolzoni PT 1 , Maior<strong>in</strong>o M 1 , Pietra C 1 ,<br />
Barbieri M 2 , Simonato M 2<br />
1 R&D Department, Chiesi Farmaceutici S.p.A., Parma; 2 Department of Cl<strong>in</strong>ical and<br />
Experimental Me<strong>di</strong>c<strong>in</strong>e, Section of Pharmacology, University of Ferrara, Ferrara<br />
12.15 INVOLVEMENT OF CENTRAL SEROTONIN RECEPTOR SUBTYPES IN THE<br />
ANTINOCICEPTIVE EFFECT OF PARACETAMOL IN THE RAT<br />
Sandr<strong>in</strong>i M., Vitale G., P<strong>in</strong>i L.A.*<br />
Sect. Pharmacology, Dept. Biome<strong>di</strong>cal Sciences and *Cl<strong>in</strong>ical Pharmacology Unit,<br />
Dept. Internal Me<strong>di</strong>c<strong>in</strong>e, University of Modena and Reggio E.<br />
133<br />
56<br />
35<br />
71<br />
92<br />
145<br />
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12.30 EFFECT OF CHRONIC TREATMENT WITH WIN 55,212-2 AND AM404 ON<br />
NITRIC OXIDE, FREE RADICALS AND PROSTAGLANDIN E2 PRODUCTION<br />
IN A RAT MODEL OF NEUROPATHIC PAIN<br />
1 Costa B., 1 Conti S., 2 Colleoni M., 1 Platania M., 2 Bianchi M., 3 Sotgiu M.L, 1<br />
Giagnoni G.<br />
1 Dipartimento <strong>di</strong> Biotecnologie e Bioscienze, <strong>Università</strong> <strong>di</strong> Milano-Bicocca, Milano;<br />
2 Dipartimento <strong>di</strong> Farmacologia, Chemioterapia e Tossicologia Me<strong>di</strong>ca, <strong>Università</strong> <strong>di</strong><br />
Milano, Milano; 3 Istituto <strong>di</strong> Neuroscienze e Bioimmag<strong>in</strong>i CNR, Milano<br />
12.45 THROMBOXANE PROSTANOID RECEPTOR IN HUMAN AIRWAY SMOOTH<br />
MUSCLE CELLS: A RELEVANT ROLE IN PROLIFERATION<br />
Capra V., *Habib A., Accomazzo M.R., Ravasi S., Citro S., A. Veltri, *Levy-<br />
Toledano S., Rovati G.E.<br />
Lababoratory of Molecular Pharmacology, Dept. of Pharmacological Sciences,<br />
University of Milan, Milan, Italy, *Unité INSERM 348, Institut Féderatif de<br />
Recherche Circulation-Lariboisière, Paris, France<br />
134<br />
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Abbadessa G. ........................................ 45; 91<br />
Abbracchio M.P. ........................... 4; 9; 54; 95<br />
Abu-Gharbieh E. ..........................................63<br />
Accomazzo M.R.................................. 96; 134<br />
Acerbi F........................................................85<br />
Aceto A. ................................................ 4; 104<br />
Adami M. .............................................. 61; 62<br />
Adamo EB....................................................66<br />
Addolorato G................................................73<br />
Ad<strong>in</strong>olfi B. ...................................................63<br />
Adriani W.............................................. 39; 92<br />
Affatato A. ...................................................66<br />
Agabiti Rosei E. ...........................................77<br />
Aglianò M. ...................................................46<br />
Agost<strong>in</strong>i M. ..................................................99<br />
Aguglia E. ....................................................27<br />
Aicar<strong>di</strong> G........................................................2<br />
Aiello C........................................................80<br />
Aiello D........................................................55<br />
Akpan V. ....................................................124<br />
Alberti D. .......................................................8<br />
Alb<strong>in</strong>i A........................................................90<br />
Alboni S. ............................................... 44; 45<br />
Ald<strong>in</strong>ucci C. .................................................90<br />
Alfieri R. ....................................................124<br />
Alfonso C. ..................................................116<br />
Alimento M..................................................54<br />
Alivern<strong>in</strong>i M.L. ............................................57<br />
Alkon D.L. .................................................108<br />
Allegretti M..................................................55<br />
Allerberger F................................................86<br />
Alleva E........................................... 11; 39; 41<br />
Allia E. .................................................. 81; 88<br />
Alloatti G......................................................65<br />
Altavilla D.54; 58; 59; 60; 61; 66; 68; 75;<br />
103; 108; 124<br />
Ama<strong>di</strong>o M. .................................................108<br />
Amadori D....................................................25<br />
Amatori F. ....................................................85<br />
Amico-Roxas M...........................................59<br />
Amoroso S............................................. 15; 25<br />
Anania V. .....................................................51<br />
Andreassi A..................................................63<br />
Andreetta F...................................................99<br />
Animati F ............................................ 80; 124<br />
Anniballi B...................................................50<br />
Annunziato L...........37; 38; 51; 103; 105; 123<br />
Antonelli T. ............................................. 6; 97<br />
Anton<strong>in</strong>i A....................................................59<br />
Antonioli L...................................................75<br />
135<br />
Apicella C. ...................................................31<br />
Aqu<strong>in</strong>o A. ..................................................113<br />
Aragona F. ...................................................26<br />
Arbia S.........................................................39<br />
Arbitrio M....................................................40<br />
Arcara C.......................................................85<br />
Arcella A......................................................34<br />
Arci<strong>di</strong>acono D................................................7<br />
Arcoraci V. ..........................................53; 119<br />
Arena S. .........................................80; 90; 120<br />
Aret<strong>in</strong>i G. ...................................................118<br />
Argilli E. ........................................................2<br />
Arletti R. ............................................114; 125<br />
Arm<strong>in</strong>io D....................................................85<br />
Arnabol<strong>di</strong> L..................................................84<br />
Aru G.N. ..................................................2; 40<br />
Asproni B.....................................................96<br />
Assmann G.................................................130<br />
Atk<strong>in</strong>son P.A................................................43<br />
Attaguile G...................................................59<br />
Aubry J.M....................................................68<br />
Aureli P........................................................50<br />
Auteri A. ......................................................45<br />
Autore G. ........................ 12; 13; 55; 113; 131<br />
Avallone R.............................................15; 67<br />
Avanz<strong>in</strong>i G...................................................74<br />
Avitabile A.......................... 9; 31; 33; 53; 127<br />
Avolio A. .....................................................86<br />
Avvantaggiato E. .........................................44<br />
Ayrol<strong>di</strong> E. ............................................71; 113<br />
Bacac M...............................................90; 128<br />
Bacchi S.....................................................116<br />
Bacch<strong>in</strong> C...................................................121<br />
Bacci C.......................................................124<br />
Badalamenti G. ............................................85<br />
Bado M. .......................................................34<br />
Baetta R. ........................................21; 84; 130<br />
Bagetta G. ................................23; 38; 83; 103<br />
Baggio G..............................................86; 107<br />
Baiar<strong>di</strong> P. ...................................................117<br />
Baj G..........................................................104<br />
Bajetto A................................................90; 91<br />
Balbo P.........................................................56<br />
Baldassarre M. .............................................87<br />
Baldu<strong>in</strong>i W.............................................23; 50<br />
Balestrieri E. ..............................................103<br />
Ballabeni V. ...................................32; 60; 100<br />
Baller<strong>in</strong>i P. .............................................29; 33<br />
Banchelli G. ...........................56; 68; 115; 116<br />
Banfi C...................................................54; 60
Banfi S..........................................................90<br />
Bani D. .................................................. 49; 70<br />
Baragatti B. ..................................................75<br />
Baral<strong>di</strong> M. ................................. 15; 24; 40; 95<br />
Baral<strong>di</strong> P.G.......................................... 33; 127<br />
Baraldo M. ............................................ 18; 46<br />
Barba M......................................................107<br />
Barban M......................................................18<br />
Barbara C. ..................................................117<br />
Barbara G. ............................................. 61; 63<br />
Barbato C. ..................................................101<br />
Barbera S......................................................85<br />
Barberi L. .....................................................62<br />
Barbero S............................................... 90; 91<br />
Barbi E. ......................................................121<br />
Barbieri F. ....................................................80<br />
Barbieri L. ..................................................124<br />
Barbieri M..................................... 30; 36; 133<br />
Barbieri S.S. ...............................................110<br />
Barb<strong>in</strong>o A.....................................................61<br />
Bardelli C. ....................................................56<br />
Bareggi S.R. ...............................................106<br />
Barocelli E..................................... 32; 60; 100<br />
Barogi S........................................................75<br />
Barone D. ................................ 26; 50; 80; 125<br />
Baroni D.....................................................124<br />
Barresi E.......................................................26<br />
Barresi V. .....................................................43<br />
Barsanti G ....................................................84<br />
Bartesaghi S. ..................................................3<br />
Bartoli F. ................................. 25; 61; 84; 121<br />
Bartol<strong>in</strong>i A............................................. 28; 32<br />
Barulli D.....................................................121<br />
Baschiera F...................................................62<br />
Bassani F....................................................133<br />
Battaglia A. ................................................104<br />
Battaglia G. .........17; 34; 66; 67; 92; 102; 104<br />
Battaglia R....................................................89<br />
Batt<strong>in</strong>elli L. ..................................................57<br />
Batt<strong>in</strong>o M. ....................................................48<br />
Battistoni M..................................................84<br />
Baviera M.....................................................39<br />
Bazzani C. ......................... 54; 55; 56; 58; 103<br />
Beani L.................................................. 36; 57<br />
Bebe B.W.......................................................6<br />
Beden<strong>di</strong> I......................................................65<br />
Behrens M......................................................3<br />
Belladonna M.L. ..........................................70<br />
Bellasio S. ....................................................44<br />
Bellik L. .................................. 57; 58; 59; 106<br />
Bell<strong>in</strong>i B. ....................................................117<br />
136<br />
Bell<strong>in</strong>i G.................................................37; 38<br />
Bell<strong>in</strong>i M......................................................63<br />
Bellomo M...................................................21<br />
Bellosta S...............................................21; 22<br />
Belluardo N..................................................43<br />
Bellucci A. .....................................................5<br />
Belluti F. ......................................................89<br />
Beltrami E......................................................9<br />
Beltramo M..................................................43<br />
Bembi B.....................................................120<br />
Benarese M ..................................................33<br />
Benatti C. .....................................................44<br />
Benedetti R. .................................................43<br />
Benelli A................................................40; 41<br />
Benetton C ...................................................86<br />
Benigni A.....................................................55<br />
Benoni G....................................................119<br />
Bentivoglio C...............................................48<br />
Benvenuti C. ................................................53<br />
Benvenuti F..................................................32<br />
Benzi G. .........................................................1<br />
Berardelli M.................................................26<br />
Berau<strong>di</strong> A...............................................29; 99<br />
Beresniak A. ..............................................117<br />
Bergamaschi M..........................................133<br />
Bergamo A...................................................89<br />
Bernabei R. ..................................................56<br />
Bernar<strong>di</strong> E..................................................102<br />
Bernasconi R..............................................122<br />
Bern<strong>in</strong>i F. ...............................................21; 22<br />
Berno E. .......................................................18<br />
Berr<strong>in</strong>o L....................................15; 21; 65; 77<br />
Berta G.N...........................................112; 127<br />
Bertani N......................................................80<br />
Bertè F. ........................................................98<br />
Bert<strong>in</strong>i R.......................................................55<br />
Bertol<strong>in</strong>i A41; 54; 55; 56; 58; 89; 103; 111;<br />
115; 116<br />
Bertone R...............................................50; 98<br />
Bertoni S. .............................................32; 100<br />
Bertorelli R. .....................................20; 43; 44<br />
Bezzi P.........................................................98<br />
Biagi G.L. ....................................................66<br />
Biagioni F. .................................................104<br />
Bianchetti A.................................................33<br />
Bianchi C. ..............................................36; 43<br />
Bianchi E. ....................................................32<br />
Bianchi M. .........................................111; 134<br />
Bianchi R. ............................................70; 122<br />
Bianch<strong>in</strong>i R. .................................................71<br />
Bianciar<strong>di</strong> L. ..............................................118
Bianco F. ......................................................10<br />
Bianconi V. ................................................102<br />
Biason P. ......................................................25<br />
Biggio F........................................................96<br />
Biggio G.............................................. 23; 121<br />
Bigiani A............................................... 54; 58<br />
Biglioli P. .....................................................54<br />
B<strong>in</strong>aglia M......................................................3<br />
B<strong>in</strong>aschi A....................................................37<br />
Birka I. .........................................................41<br />
Biscont<strong>in</strong> G. .................................................25<br />
Bisgaier C.L. ................................................24<br />
Bisi A. ..........................................................89<br />
Bisogno T.....................................................94<br />
Bitto A............................................. 59; 68; 75<br />
Bizzarri C. ........................................... 55; 121<br />
Bizzoca A.....................................................39<br />
Blanco Garcia J. ...........................................90<br />
Blan<strong>di</strong>zzi C................62; 63; 75; 79; 117; 127<br />
Blar<strong>di</strong> P. .......................................................45<br />
Blom J.M.C........................................... 44; 45<br />
Boccalon S. ..................................................38<br />
Bocci G. .............................................. 84; 117<br />
Boccotti L.....................................................54<br />
Boccuti S......................................................57<br />
Boiar<strong>di</strong> A......................................................84<br />
Boldr<strong>in</strong>i E.....................................................64<br />
Boldr<strong>in</strong>i L.....................................................85<br />
Bolego C. .....................................................21<br />
Bolle P..........................................................50<br />
Bolzoni P.T. ...............................................133<br />
Bombelli R. ........................................... 47; 70<br />
Bombi G................................................ 10; 33<br />
Bompadre S..................................................48<br />
Bonanno G. ..................................... 37; 69; 99<br />
Bonavia R.............................................. 90; 91<br />
Bonazzi A.....................................................39<br />
Bonc<strong>in</strong>elli E....................................................1<br />
Bonerba E.......................................................2<br />
Bonfanti A..................................... 23; 34; 101<br />
Bongrani S....................................................53<br />
Boni S.........................................................116<br />
Bon<strong>in</strong>a F.P..................................................100<br />
Bonmassar E. .............................................113<br />
Bonomo S.M. ...............................................67<br />
Bonucchi D. .................................................46<br />
Booth E.A.....................................................24<br />
Borea P.A..................4; 9; 31; 33; 53; 54; 127<br />
Boroni F .......................................................33<br />
Borrelli F......................................................75<br />
Bortolato M............................................. 2; 40<br />
137<br />
Bosari S..................................................18; 89<br />
Boscaro V. ...................................................46<br />
Boschi F.......................................................63<br />
Bosch<strong>in</strong>i E..................................................130<br />
Boselli C. .............................................64; 108<br />
Bosisio E......................................................22<br />
Botarelli M...........................................57; 131<br />
Botrè F. ......................................................121<br />
Botticelli A.R.......................................55; 103<br />
Bott<strong>in</strong>elli R...................................................63<br />
Bottiroli G....................................................50<br />
Bovara M. ................................................2; 61<br />
Bowery N.G.................................................38<br />
Braghiroli D...................................24; 95; 124<br />
Braida D...............................................23; 106<br />
Brambilla G..........................................57; 124<br />
Brambilla L..................................................98<br />
Brambilla M...............................................110<br />
Brancaccio D. ..............................................18<br />
Brancaleone V. ................................21; 31; 53<br />
Branchi I. ...............................................39; 41<br />
Branciforte D. ............................................121<br />
Brasseur P. .................................................117<br />
Bredesen D...................................................98<br />
Bregola G.....................................................37<br />
Breschi M.C...................................63; 93; 127<br />
Brescia A. ..............................................29; 38<br />
Bresciani E...................................................67<br />
Bresol<strong>in</strong> N....................................................99<br />
Brignoli O. .................................................132<br />
Brigotti M...................................................124<br />
Br<strong>in</strong>i E..........................................................41<br />
Britti D...........................................48; 67; 111<br />
Broccardo M ................................................63<br />
Broccoli M...................................................66<br />
Brollo L..................................................46; 87<br />
Brovia D.....................................................116<br />
Brullo C. ......................................................60<br />
Brunelleschi S......................................56; 112<br />
Brunello N. ................................27; 44; 45; 69<br />
Bruni G. .......................................................32<br />
Bruno F. .......................................................16<br />
Bruno O. ......................................................60<br />
Bruno V. ..................................9; 34; 102; 104<br />
Brusadelli A.................................................21<br />
Bruscoli S.....................................................70<br />
Bruzzone S...................................................29<br />
Buccella S. .............................................29; 33<br />
Buccellati C. ..............................................112<br />
Bucci M. ..........................................21; 31; 53<br />
Buda S................................................118; 119
Buettner R ....................................................26<br />
Bulgarelli I. ........................................... 67; 76<br />
Bullon P........................................................48<br />
Bulotta S.......................................................88<br />
Bur<strong>di</strong> R.........................................................99<br />
Burne T. .....................................................104<br />
Busalacchi A. .................................................7<br />
Busceti C.L.......................................... 92; 104<br />
Busonero F. ........................................... 93; 96<br />
Bussolati B. ..................................................80<br />
Bussol<strong>in</strong>o F. .................................................22<br />
Bustacch<strong>in</strong>i S..............................................118<br />
Buzi F.........................................................122<br />
Cabibi D. ......................................................26<br />
Cabras S. ......................................................96<br />
Caciagli F. ......................................... 9; 29; 33<br />
Cadossi R. ....................................................31<br />
Cafè C. .........................................................98<br />
Cagiano R.......................................... 6; 39; 93<br />
Cagnotto A. ................................................125<br />
Cagol P.........................................................25<br />
Caiani A. ......................................................54<br />
Ca<strong>in</strong>azzo M.M................... 54; 55; 56; 58; 103<br />
Calabresi L. ................................................130<br />
Calamandrei G. ................................. 107; 108<br />
Calapai G.................16; 21; 94; 108; 119; 124<br />
Calascibetta A ..............................................26<br />
Calatozzolo C...............................................84<br />
Calc<strong>in</strong>a F. ...................................................100<br />
Calderone V. ................................................57<br />
Calienni M....................................................52<br />
Calignano A. ........................................... 6; 94<br />
Calissano P.................................................101<br />
Calò G. ...................................... 15; 31; 44; 56<br />
Calò L.A.................................... 33; 54; 57; 97<br />
Caltagirone C. ............................................103<br />
Calvagno M.G..............................................88<br />
Calvani M............................................ 28; 130<br />
Camarda V. ..................................................56<br />
Camer<strong>in</strong>o C. .................................................99<br />
Campana G.......................................... 62; 122<br />
Campanella M..............................................43<br />
Campanella S. ............................................118<br />
Campi B. ......................................................32<br />
Campione M.................................................26<br />
Campolongo P..............................................41<br />
Camurri A. ............................................ 54; 95<br />
Camussi G............................................. 64; 80<br />
Canaparo R............................................ 18; 88<br />
Canavesi M. .......................................... 21; 22<br />
Canciani L............................................. 33; 35<br />
138<br />
Candeletti S............................................36; 93<br />
Candussio L. ........................................61; 121<br />
Canepa R......................................................16<br />
Canev<strong>in</strong>i P....................................................18<br />
Cangemi L. ..................................................45<br />
Cangianiello M ............................................64<br />
Caniglia S.........................................4; 47; 100<br />
Canistro D....................................................66<br />
Cannarile L. .................................................70<br />
Cannazza G..................................................95<br />
Cannella A .....................................................9<br />
Canonico P.L. ....................................104; 129<br />
Canossa M. ..............................................2; 36<br />
Cantara S....................................................130<br />
Cantelli Forti G....................................66; 124<br />
Canti G.........................................................90<br />
Cantoni O...................................101; 111; 119<br />
Cantore M. .......................................55; 56; 63<br />
Cantoreggi S. ...............................................80<br />
Canzoniero L.M.T. ......................................51<br />
Capasso A. .......... 31; 41; 67; 68; 94; 106; 122<br />
Capasso F...............................................75; 94<br />
Capasso R. .............................................75; 94<br />
Capecchi P.L................................................54<br />
Capobianco L.........................................33; 67<br />
Capobianco R...............................................98<br />
Capone A. ..........................................118; 119<br />
Capone F......................................................39<br />
Capone G. ....................................................45<br />
Capone M. L. ...............................................18<br />
Cappa M.....................................................121<br />
Cappellari G.................................................86<br />
Cappello S................................................2; 36<br />
Cappuccio I..............................66; 96; 99; 103<br />
Capra V........................................96; 111; 134<br />
Capr<strong>in</strong>o L...........................................116; 132<br />
Caprioli A. .............................................39; 92<br />
Capuano A. ..................................................86<br />
Caputi A.P.16; 21; 45; 48; 53; 55; 59; 60; 61;<br />
66; 68; 75; 97; 108; 110; 111; 112; 115;<br />
117; 119; 124; 131<br />
Caputo A......................................................89<br />
Caraci F................................................40; 103<br />
Cardaioli C...................................................86<br />
Cardali S. .....................................................45<br />
Carelli G.......................................................52<br />
Carelli S. ......................................................89<br />
Carelli V.........................................................5<br />
Caria S. ........................................................96<br />
Caricasole A29; 40; 42; 66; 98; 99; 101; 102;<br />
103
Carletti M. ....................................................91<br />
Carli M. ........................................................39<br />
Carloni S. .............................................. 23; 50<br />
Carluccio E...................................................77<br />
Carm<strong>in</strong>ati P. .................................. 46; 57; 131<br />
Carnicelli D................................................124<br />
Carn<strong>in</strong>i C....................................................112<br />
Carnuccio R..................................... 47; 48; 71<br />
Caroleo B ...................................................114<br />
Carrà G.................................................. 31; 44<br />
Carrara M. ....................................................89<br />
Carratù M.R. ................................... 6; 11; 108<br />
Carretta R. ..................................................114<br />
Carrozz<strong>in</strong>o R. .............................................118<br />
Carruba M. .............................................. 1; 75<br />
Carsana T. ..................................................102<br />
Carta A.R. ....................................................92<br />
Cartei G............................................... 25; 127<br />
Cartoni A....................................................124<br />
Carusio N. ....................................................59<br />
Caruso A. ................29; 96; 98; 101; 102; 103<br />
Caruso E.......................................................90<br />
Caruso M......................................................89<br />
Casa<strong>di</strong>o C. ....................................................85<br />
Casale F........................................................18<br />
Casamenti F............................... 5; 31; 83; 107<br />
Casarsa C............................................. 89; 128<br />
Casc<strong>in</strong>o A.....................................................59<br />
Cascio C. ........................................................4<br />
Cas<strong>in</strong>i P. .......................................................51<br />
Casnici C......................................... 47; 48; 67<br />
Casolari C.....................................................86<br />
Casol<strong>in</strong>i P. ....................................................34<br />
Cassano T.......................................... 104; 108<br />
Cassone M.C. ...............................................46<br />
Cassoni P......................................................81<br />
Castagnetti M. ............................................101<br />
Castaldo P. .................................... 37; 38; 105<br />
Castellar<strong>in</strong> A. ...................................... 90; 128<br />
Castelli M............................................ 86; 107<br />
Castelnuovo M. ............................................90<br />
Castiglione M...................................... 98; 101<br />
Castor<strong>in</strong>a M..................................................92<br />
Castri P.........................................................95<br />
Castrogiovanni P..........................................45<br />
Catalani A. ............................................ 34; 42<br />
Catalano A....................................................25<br />
Catalano MG................................................88<br />
Catania M.A.................... 16; 21; 94; 108; 119<br />
Catania M.V.......................................... 40; 99<br />
Catapano A...................................................72<br />
139<br />
Catapano F...................................................65<br />
Catapano M................................................117<br />
Cataudella T...............................................104<br />
Cattabeni F.................................................2; 9<br />
Cattabriga E .................. 9; 31; 33; 53; 54; 127<br />
Cattaneo E......................................83; 95; 104<br />
Cattaneo L..............................................47; 48<br />
Cattaneo M.G.........................................53; 88<br />
Cattaruzza F...............................................100<br />
Cauda R. ....................................................113<br />
Cauli O.........................................................92<br />
Cavalca V.....................................................54<br />
Cavalieri B...................................................55<br />
Cavallaro A..................................................86<br />
Cavalli R. .............................................88; 115<br />
Cavall<strong>in</strong>i P. ..................................................43<br />
Cavallo F....................................................112<br />
Cavanni P.....................................................43<br />
Cavazzani P. ................................................29<br />
Ceccarelli P................................................118<br />
Cecchi E.............................................115; 116<br />
Cecch<strong>in</strong> E.....................................................25<br />
Ceci A. ...............................................117; 132<br />
Celano E.......................................................43<br />
Celano M. ....................................................88<br />
Cella S.G..............................................67; 121<br />
Centanni S..................................................100<br />
Cerbai E. ........................... 53; 56; 58; 65; 130<br />
Cereda E.......................................................80<br />
Cerretani D........................ 51; 81; 84; 86; 133<br />
Cerri R. ........................................................96<br />
Ceruti S. ...................................................9; 98<br />
Cervello M...................................................91<br />
Cervetto C....................................................23<br />
Cervio E.......................................................61<br />
Cesano L. ...........................................122; 127<br />
Cetrone M. ...................................................99<br />
Cevolani A...................................................93<br />
Chairugi A. ................................................123<br />
Chatterjee P.K..............................................97<br />
Chen H.......................................................120<br />
Chessa G. .....................................................36<br />
Chiamenti G.P............................................119<br />
Chiariello R..................................................72<br />
Chiarpotto E...............................................122<br />
Chiavar<strong>in</strong>i M..................................32; 60; 100<br />
Chiechio S............................................40; 104<br />
Chiesa A.....................................................133<br />
Ch<strong>in</strong>ellato A...............................................118<br />
Chiocchetti A...............................................70<br />
Chiozzi P....................................................133
Chisari M............................................... 44; 59<br />
Chollet A......................................................64<br />
Ciabattoni G. ................................................75<br />
Ciana G.. ....................................................120<br />
Ciarmela P....................................................81<br />
Cicala C............................................... 75; 111<br />
Ciccarelli R. ...................................... 9; 29; 33<br />
Cicero A.F.G.......45; 114; 115; 120; 121; 125<br />
Cichetti C. ......................................... 100; 102<br />
Cignarella A. ....................................... 21; 130<br />
Ciliberti N. ...................................................58<br />
Cim<strong>in</strong>o M. ............................................. 23; 50<br />
C<strong>in</strong>i E. ............................................... 115; 116<br />
C<strong>in</strong>que C. .....................................................34<br />
Cioni L. ........................................................56<br />
Cioppa T.......................................................84<br />
Ciotti M.T...................................................101<br />
Cipollone F.................................................126<br />
Cirica A........................................... 33; 96; 97<br />
Cirillo R........................................................64<br />
Cir<strong>in</strong>o G............................... 13; 21; 31; 53; 75<br />
Cirulli F........................................................41<br />
Citraro R.......................................................43<br />
Citro S. .............................................. 111; 134<br />
Ciuffi M........................................... 55; 56; 63<br />
Ciusani E......................................................84<br />
Civalleri L. .................................................116<br />
Clementi F......................................................1<br />
Cocchi D. ............................................ 65; 122<br />
Cocchietto M....................................... 90; 128<br />
Cocci A. .......................................................19<br />
Codenotti M. ..................................... 107; 109<br />
Colangelo D. ......................................... 85; 89<br />
Colasanti M................................................111<br />
Colleoni M. ................................................134<br />
Colli S. .......................................................110<br />
Coll<strong>in</strong>o M. ........................................... 48; 133<br />
Colombo G...................................................73<br />
Colosimo M................................................114<br />
Colotta F.......................................................55<br />
Colucci R............................................. 63; 127<br />
Coluccia A..................................... 39; 93; 108<br />
Comparato C. ...................................... 84; 130<br />
Concas A....................................................121<br />
Cond<strong>in</strong>o A.M. ..................................... 64; 108<br />
Condorelli D.F. ............................................43<br />
Condorelli F. ..............................................129<br />
Confalonieri P. .............................................99<br />
Conforti A. ...................................................19<br />
Consalez G. ..................................................23<br />
Consoli D. ......................................................6<br />
140<br />
Constanti A. .......................................3; 44; 45<br />
Constant<strong>in</strong> G.¶ ...........................................112<br />
Conte Camer<strong>in</strong>o D ................ 2; 30; 54; 65; 99<br />
Conti A.........................................................45<br />
Conti L.......................................................104<br />
Conti S. ......................................................134<br />
Copani A..............................40; 103; 104; 129<br />
Coppi A......................................................107<br />
Copp<strong>in</strong>i A.....................................................53<br />
Coppola A..............................................47; 66<br />
Coppola G..............................................37; 38<br />
Coppol<strong>in</strong>o M.F...........................................116<br />
Corad<strong>in</strong>i D. ................................................128<br />
Corasaniti M.T.....................................23; 103<br />
Cordelli E.....................................................51<br />
Cor<strong>in</strong>aldesi R. ........................................61; 63<br />
Corona G......................................................25<br />
Corradetti R. ........................................2; 9; 23<br />
Correale P ............................................47; 113<br />
Corsaro A.......................... 4; 80; 90; 104; 120<br />
Corsi M. .......................................................43<br />
Cors<strong>in</strong>i A................................21; 84; 104; 130<br />
Cors<strong>in</strong>i E. .......................................................3<br />
Corti L..........................................................68<br />
Cort<strong>in</strong>ovis S. ................................................67<br />
Coruzzi G...............................................61; 62<br />
Corvetti G. .........................................112; 127<br />
Cosciani Cunico S........................................64<br />
Cosent<strong>in</strong>o M...........................................47; 70<br />
Costa B.................................................41; 134<br />
Costa F.........................................................63<br />
Costa L.G.........................................11; 31; 39<br />
Costa M..........................................18; 79; 117<br />
Costa N. .................................................40; 44<br />
Costant<strong>in</strong>o G. ...............................................33<br />
Costanzo A...................................................41<br />
Cottone P. ......................................................7<br />
Couture R.....................................................37<br />
Cozzi A. .....................................................123<br />
Cozzol<strong>in</strong>o A...............................................115<br />
Cremonesi B. ...............................................24<br />
Crepal<strong>di</strong> G..................................................116<br />
Crescimanno M............................................85<br />
Crestani M. ..................................................22<br />
Crisafulli A. .................................................66<br />
Crisp<strong>in</strong>o L. .............................................85; 89<br />
Crist<strong>in</strong>a S. ....................................................85<br />
Croce A.C. ...................................................50<br />
Croci D.........................................................84<br />
Croci L.........................................................23<br />
Croci R.........................................................25
Crupi A.........................................................94<br />
Cuda G. ........................................................63<br />
Cullen P......................................................130<br />
Cuomo R. .....................................................61<br />
Cuomo V.................6; 7; 11; 39; 93; 104; 108<br />
Cupani C. ...................................................119<br />
Currò D. ................................................ 62; 76<br />
Cusi M.G....................................................113<br />
Cutrín J.C. ....................................................55<br />
Cutroneo P........................................... 53; 119<br />
Cuzzocrea S.13; 40; 45; 48; 53; 55; 67; 70;<br />
75; 97; 110; 111; 112; 113; 131<br />
Cuzzol<strong>in</strong> L..................................................119<br />
D’ Emmanuele <strong>di</strong> Villa Bianca R. .. 12; 13; 55<br />
D’Abramo E.U...........................................116<br />
D’Addario C.......................................... 36; 93<br />
D’Ad<strong>di</strong>o F. .................................................119<br />
D’Agost<strong>in</strong>o B. ..............................................64<br />
D’Agost<strong>in</strong>o G...................................... 64; 108<br />
D’Agost<strong>in</strong>o S..................................................4<br />
D’Alessandro N............................................91<br />
D’Alessio A..................................................51<br />
D’Alimonte I........................................... 9; 29<br />
D’Ambrosi N................................................54<br />
D’Amico M..................................... 38; 65; 77<br />
D’Aquila P.S. ...............................................36<br />
D’Arrigo C. ................................................115<br />
D’Auro M.............................................. 29; 33<br />
D’Emmanuele <strong>di</strong> Villa Bianca R. ................55<br />
D’Incalci M..................................................14<br />
D’Onofrio M. ........................................ 34; 99<br />
D’Urso G......................................................43<br />
Dacasto M. ...................................................91<br />
Daidone M.G..............................................128<br />
Dal Piaz V. .................................................112<br />
Dall’Olio R...................................................97<br />
Dalle Carbonare M.........................................7<br />
Danesi R..........................8; 14; 25; 84; 85; 89<br />
Daniele C......................................................57<br />
Dapas B........................................................81<br />
Dardanoni G.................................................26<br />
De Alba J....................................................103<br />
De Amici M. ................................................32<br />
de Angelis L.................................................44<br />
de Bartolomeis A. ........................................43<br />
De Bene<strong>di</strong>ctis L............................................39<br />
De Blasi A............................................. 33; 92<br />
De Braud F.....................................................8<br />
De Cater<strong>in</strong>a R...............................................82<br />
De Cesare G. ..............................................119<br />
De Curtis M................................................112<br />
141<br />
De Felice M. ................................................32<br />
De Feo G....................................................121<br />
De Feo V......................................................31<br />
De Franceschi M..........................................54<br />
De Francia S. .............................................122<br />
De Giorgio R....................................61; 63; 79<br />
De Gregorio P..............................................85<br />
De Iovanna M.A. ...............................106; 122<br />
de la Riva C.F. ...........................................108<br />
De Lalla A....................................................45<br />
De Leo G........................................................4<br />
De Lima T.C.M............................................15<br />
De Logu M.R.................................................4<br />
De Luca A.M. ....................... 2; 30; 36; 65; 99<br />
De Marco T............................................62; 76<br />
De Maria R. ...........................................97; 98<br />
De Mattei M.................................................97<br />
De Matteis F. ...............................................51<br />
De Micheli A. ............................................104<br />
De Micheli C................................................32<br />
De Montis M.G..........................28; 36; 44; 93<br />
De Nardo M. ................................................64<br />
de Novellis V. ........................................15; 37<br />
De Novellis V. .............................................15<br />
De Palma R..................................................72<br />
De Paoli P. ...............................56; 58; 65; 130<br />
De Ponti F........................................61; 63; 79<br />
De Portu S..................................................118<br />
De Rosa G....................................................64<br />
De Salvatore G. ....................................54; 113<br />
De Salvia M.A. ..........................................113<br />
De Santi S. .............................................41; 42<br />
De Sarro A. ....................................53; 67; 131<br />
De Sarro G.B. ....... 40; 43; 44; 63; 74; 85; 114<br />
De Siena G...................................................41<br />
De Simoni M.G............................................23<br />
De Stefano A................................................84<br />
De Stefano C..............................................117<br />
De Stefano D....................................47; 48; 71<br />
De Vecchis L. ............................................113<br />
De V<strong>in</strong>centi O..............................................54<br />
Debetto P. ....................................15; 106; 118<br />
Decorti G. ......................................61; 88; 121<br />
Deghenghi R. ...............................................67<br />
Degli Esposti E. .........................118; 119; 132<br />
Degli Esposti L ..................................118; 119<br />
Del Basso P..............................57; 58; 59; 111<br />
Del Bianco P..........................................42; 66<br />
Del Duca C. ...............................................103<br />
Del Guerra M.............................................119
Del Tacca M.8; 25; 62; 63; 75; 79; 84; 85; 89;<br />
117; 126; 127<br />
Delf<strong>in</strong>o D.V..................................................99<br />
Delf<strong>in</strong>o R......................................................89<br />
Dell’Agli M..................................................22<br />
Dell’Erba A..................................................45<br />
Della Corte L..................................................2<br />
Della Pepa C........................................ 18; 132<br />
Dellabianca A...............................................64<br />
Dellarole A........................................ 106; 107<br />
Delogu M.R..................................... 5; 36; 101<br />
Deodato B. ...................................... 21; 60; 68<br />
Derosa G. ............................................ 45; 121<br />
Desaphy J.-F.................................... 30; 54; 65<br />
Desole M.S.................................. 4; 5; 36; 101<br />
Di Benedetto M..................................... 36; 93<br />
Di Carlo C ....................................................66<br />
Di Carlo F................45; 80; 91; 112; 122; 127<br />
Di Carlo G....................................................75<br />
Di Carlo M. ................................................116<br />
Di Carlo R. ...................................... 47; 48; 66<br />
Di Cesare Mannelli L...................................28<br />
Di Chiara G. .................................................78<br />
Di Cioccio V. ...............................................55<br />
Di Felice A................................ 46; 49; 70; 92<br />
Di Gennaro A.............................................112<br />
Di Giannuario A.................................. 41; 112<br />
Di Giorgi Gerev<strong>in</strong>i V.33; 66; 96; 97; 98; 99;<br />
101<br />
Di Giovanni S........................................ 32; 75<br />
Di Giulio A.M...18; 63; 89; 99; 100; 102; 115<br />
Di Giuseppe D..................................... 56; 115<br />
Di Iorio P........................................... 9; 29; 33<br />
Di Lorenzo A. ..............................................31<br />
Di Loreto G ........................................... 41; 42<br />
Di Luca M. .............................................. 3; 17<br />
Di Marco B.................................................113<br />
Di Mart<strong>in</strong>o M .................................... 118; 119<br />
Di Marzo V. ........................................ 6; 7; 94<br />
Di Meglio P................................................112<br />
Di Menza G..................................................18<br />
Di Paola R ........................... 97; 110; 111; 131<br />
Di Paola R. ..................45; 48; 53; 55; 67; 112<br />
Di Paolo A............................... 25; 84; 85; 117<br />
Di Qual E. ............................................. 46; 87<br />
Di Renzo G.F. ............................. 51; 103; 105<br />
Di Rosa M. .................. 97; 100; 110; 112; 130<br />
Di Sario F.....................................................63<br />
Di Simplicio P..................................... 56; 115<br />
Di Stasi F....................................................117<br />
Di Stefano A.B. ............................................99<br />
142<br />
Di Toro R.......................................................3<br />
Di Virgilio F. .............................................133<br />
Diana F.......................................................120<br />
Diana G..........................................................6<br />
Dianzani C. ..........................................48; 133<br />
Dianzani U...................................................70<br />
Didonna M.........................................2; 30; 99<br />
Dolara P. ....................................................124<br />
Dolc<strong>in</strong>i V. ..................................4; 28; 95; 108<br />
Domenici M.R. ........................................4; 97<br />
Dom<strong>in</strong>ici L.................................................112<br />
Donato <strong>di</strong> Paola E. .......................................44<br />
Donetti E....................................................130<br />
Donn<strong>in</strong>i S.......................................58; 60; 130<br />
Doria D. .......................................................51<br />
Dossena M. ..................................................63<br />
Doublier S....................................................64<br />
Dragic Z.....................................................102<br />
Drago F. .........................................1; 6; 27; 92<br />
Drago G. ........................................................4<br />
Dragoni S.............................................51; 106<br />
Drigo I........................................................121<br />
Dugo G.......................................................112<br />
Dugo L.......................................48; 53; 55; 97<br />
Dugo P. ......................................................112<br />
Dvorscakova M..........................................102<br />
Ean<strong>di</strong> M. ........................................18; 88; 115<br />
Eleuteri P. ....................................................51<br />
Elia L. ............................................................2<br />
Elig<strong>in</strong>i S. ....................................................110<br />
Engel T.......................................................130<br />
Esculapio P. .................................................45<br />
Esposito E ..............................................47; 66<br />
Esposito G................................5; 36; 100; 101<br />
Esposito M.....................................59; 61; 108<br />
Esposito S. ...................................................86<br />
Evandri M.G. ...............................................50<br />
Evangelista S. ..............................................53<br />
Evangelisti C..............................................124<br />
Evangelisti L................................................62<br />
Fabbretti E. ..................................................38<br />
Fabbri A.......................................................50<br />
Fabi F.......................................57; 58; 59; 111<br />
Fabris B........................................................57<br />
Facch<strong>in</strong>etti F. ...............................................15<br />
Faccioni F. ...................................................51<br />
Faedo S. .......................................................43<br />
Failli P..............................................55; 56; 63<br />
Falaschi P...................................................120<br />
Falciani M....................................................64<br />
Falcone A.....................................................25
Fallar<strong>in</strong>o F....................................................70<br />
Falzano L......................................................50<br />
Falzarano S...................................................46<br />
Falzoni S. ...................................................133<br />
Fantappiè O..................................................92<br />
Fant<strong>in</strong> M.......................................................89<br />
Fantozzi R. .............................. 22; 48; 70; 133<br />
Fariello R......................................................74<br />
Far<strong>in</strong>a R................................................. 41; 94<br />
Fasoli E. .......................................................32<br />
Fava G............................................... 115; 119<br />
Favalli L. ....................................................108<br />
Favari E........................................................21<br />
Favero P. ......................................................89<br />
Fedele E................................................. 29; 38<br />
Fedeli A........................................................93<br />
Feliciani D....................................................36<br />
Feligioni M............................................ 29; 34<br />
Felisi M. .....................................................117<br />
Fenicia L. .....................................................50<br />
Fenu S. .......................................................104<br />
Feo S. ...........................................................26<br />
Ferlito C. ........................................... 115; 116<br />
Ferraguti C. ........................................... 44; 45<br />
Ferrara P.....................................................130<br />
Ferrari A.....................................................115<br />
Ferrari D.....................................................133<br />
Ferrari M. ................................ 18; 47; 70; 116<br />
Ferrari Ton<strong>in</strong>elli G. ........................... 107; 109<br />
Ferrario S......................................................54<br />
Ferraro L. ................................................ 6; 97<br />
Ferrazzi E ...................................................116<br />
Ferreiro M.S.................................................48<br />
Ferreri G.............................................. 44; 114<br />
Ferri N..........................................................84<br />
Ferri S................................................ 106; 107<br />
Ferrigno A............................................. 50; 98<br />
Ferro F........................................................118<br />
Festa M.......................................................103<br />
Fiaschi A.I................................... 86; 115; 133<br />
Filabozzi P....................................................25<br />
Filaferro M. ................................... 47; 89; 111<br />
Filippelli A. ..................................... 59; 77; 86<br />
Filippelli W. .................................................59<br />
Filippi C. ............................................. 64; 116<br />
Filippi S........................................... 57; 58; 59<br />
Fille M..........................................................86<br />
F<strong>in</strong>etti S........................................................97<br />
Fiorani M....................................................119<br />
Fiorani S.......................................................50<br />
Fiore G. ........................................................81<br />
143<br />
Fiorent<strong>in</strong>i C..................................................50<br />
Fioretti M.C. ................................................70<br />
Firenzuoli F..................................................94<br />
Firuzi O......................................................102<br />
FitzGerald G. .............................................126<br />
Fland<strong>in</strong>a C....................................................85<br />
Flocco M.A................................................114<br />
Flor P.J.......................................................102<br />
Floreani M. ..................................................89<br />
Florio C............................... 10; 12; 29; 32; 33<br />
Florio P. .......................................................81<br />
Florio T. ............................ 4; 80; 90; 104; 120<br />
Floris I..........................................................94<br />
Floris S.........................................................94<br />
Folco G. .........................................54; 59; 112<br />
Follesa P.................................................93; 96<br />
Fontana M....................................................61<br />
Forghieri M................................................114<br />
Forlani A......................................................43<br />
Fornai F................................................92; 104<br />
Fornai M. ...............................................62; 75<br />
Fornari S. .....................................................64<br />
Forte A.........................................................59<br />
Forte P........................................................115<br />
Fort<strong>in</strong>i C.........................................................9<br />
Fortuna A...................................................122<br />
Fournier J.....................................................97<br />
Fracasso M.E. ..............................................51<br />
Fracchiolla G. ................................................2<br />
Frairia R.......................................................88<br />
Francescato P...............................................53<br />
Franceschetti P.............................................51<br />
Franceschi A. .............................................117<br />
Franceschi L.............................18; 25; 46; 125<br />
Francesch<strong>in</strong>i G...........................................130<br />
Francesch<strong>in</strong>is E............................................48<br />
Franchi-Micheli S. ...........................55; 56; 63<br />
Franc<strong>in</strong>i G. .....................................47; 86; 113<br />
Francioli E. ................................................104<br />
Francisconi S. ....................................102; 107<br />
Franconi F..................................................133<br />
Franconi M...................................................59<br />
Frank C. ...............................................97; 109<br />
Frasca G.....................................................104<br />
Fratta W. ......................................................73<br />
Fratto D........................................................63<br />
Frau R. .....................................................2; 40<br />
Fraus<strong>in</strong> F. .....................................................90<br />
Fraysse B. ..............................................65; 99<br />
Fredduzzi S. .................................................43<br />
Freitas I. .................................................50; 98
Fresta M. ......................................................88<br />
Frieri G.........................................................62<br />
Frigeri C. ......................................................41<br />
Frigo G.M.................................. 33; 35; 47; 70<br />
Frosali S. ............................................. 56; 115<br />
Fros<strong>in</strong>i M............................... 12; 13; 106; 107<br />
Fu J.................................................................7<br />
Fuccio C. ......................................................15<br />
Fulceri F. ......................................................89<br />
Fulfaro F.......................................................85<br />
Fumagalli F. ........................................ 69; 112<br />
Fumagalli G..................................................95<br />
Fumagalli M.................................................54<br />
Funahashi T................................................120<br />
Funicello M................................................125<br />
Furlani A. .....................................................90<br />
Furlanut M...................18; 25; 46; 86; 87; 125<br />
Fusco A. .......................................................80<br />
Fusi F............................................... 12; 13; 53<br />
Fuxe K..........................................................97<br />
Fuzzati N......................................................22<br />
Gad<strong>di</strong> A............................................. 120; 121<br />
Gaetani S............................................... 7; 108<br />
Gaion R.M................................. 10; 29; 32; 33<br />
Gala R. .......................................................105<br />
Galantucci M................................................47<br />
Galasso R. ..................................................116<br />
Galatti L. ....................................................119<br />
Gal<strong>di</strong>ero E. ...................................................48<br />
Gal<strong>di</strong>ero M. ..................................................48<br />
Galeotti N.............................................. 28; 32<br />
Galietta G. ........................................... 67; 122<br />
Galizzi G. .......................................................4<br />
Gallardo I. ....................................................48<br />
Gallelli L ................................. 63; 64; 85; 114<br />
Gallesi D. .......................................... 115; 116<br />
Galli C................................................. 82; 120<br />
Galli C.L.........................................................3<br />
Galli U..........................................................61<br />
Galliani G...................................................122<br />
Gallicchio M. ...................................... 22; 133<br />
Galluzzo M.................................................100<br />
Gambarana C................................... 28; 44; 93<br />
Gambardella L............................................113<br />
Gambassi G..................................................56<br />
Gandolfi O....................................................97<br />
Gangemi M. ...............................................119<br />
Garbero C...................................................118<br />
Gardoni F. ............................................. 3; 123<br />
Gareri P. .......................................................43<br />
Garibol<strong>di</strong> M.B. ...................................... 80; 90<br />
144<br />
Garrone B...............................................41; 42<br />
Gasco A. ......................................................61<br />
Gasco M.R. ..........................................88; 115<br />
Gaspar<strong>in</strong>i F.................................................102<br />
Gaspar<strong>in</strong>i L. .................................................83<br />
Gaspar<strong>in</strong>i P...................................................65<br />
Gau<strong>di</strong> S. .......................................................97<br />
Gava B. ................................................88; 128<br />
Gavioli E.C. ...........................................15; 44<br />
Gavioli R........................................................9<br />
Gazzieri D....................................................63<br />
Geary N........................................................93<br />
Gebbia N......................................................85<br />
Gelati M.......................................................84<br />
Gelosa P.................................................24; 60<br />
Genedani S...............................41; 47; 89; 111<br />
Gennarelli M....................................15; 43; 69<br />
Gennar<strong>in</strong>i G. ................................................39<br />
Gennuso F........................................4; 47; 100<br />
Genova F....................................4; 28; 95; 108<br />
Genovese R..................................................37<br />
Genovese T. .. 45; 48; 53; 55; 67; 97; 110; 112<br />
George A.L. .................................................30<br />
Geppetti P. ........................ 32; 63; 79; 96; 106<br />
Geroni C.......................................................89<br />
Gerosa P.......................................................23<br />
Gervasoni M. .............................................106<br />
Gessa G.L. ................................ 1; 2; 6; 40; 73<br />
Gessi S. ............................... 9; 31; 33; 53; 127<br />
Ghè C...........................................................81<br />
Ghelard<strong>in</strong>i C...........................................28; 32<br />
Ghezzi A. .....................................................70<br />
Ghezzo F............................................122; 127<br />
Ghi P. .................................................106; 107<br />
Ghia M.........................................................16<br />
Ghiaroni V. ..................................................54<br />
Ghiglia A. ..............................................85; 89<br />
Ghiglieri V.....................................................6<br />
Ghirar<strong>di</strong> O....................................................39<br />
Ghisu N......................................................127<br />
Ghizzar<strong>di</strong> P. ...............................................100<br />
Giacalone M.................................................56<br />
Giacca M................................................60; 68<br />
Giaccone G. .................................................98<br />
Giagnoni G.................................................134<br />
Giai Pron R. ...............................................127<br />
Giammarioli A.............................................50<br />
Giampietro R. ......................................80; 124<br />
Gianaroli L.................................................117<br />
Gianazza E...................................................24<br />
Gianfriddo M. ................................................9
Giangaspero F. .............................................34<br />
Giannacc<strong>in</strong>i G. .............................................63<br />
Gianni W......................................................25<br />
Giann<strong>in</strong>i E. ............................................ 32; 75<br />
Giann<strong>in</strong>i L. ...................................... 49; 70; 92<br />
Giannitrapani L. ...........................................91<br />
Gianorso S....................................................51<br />
Giaroni C............................................... 33; 35<br />
Gigante D. ....................................................93<br />
Gillio Tos E..................................................64<br />
G<strong>in</strong>iatull<strong>in</strong> R.................................................20<br />
Giobbi G.....................................................116<br />
Gioglio L......................................................64<br />
Giorda G.......................................................25<br />
Giordani L....................................................47<br />
Giorgi G.31; 47; 51; 62; 81; 84; 86; 113; 115;<br />
118; 133<br />
Giovannetti E. ....................................... 84; 85<br />
Giovann<strong>in</strong>i L. ...................................... 64; 116<br />
Giovann<strong>in</strong>i M.G. ............................... 2; 5; 107<br />
Giovannoni M.P.........................................112<br />
Giral<strong>di</strong> T.............................................. 61; 121<br />
Giron M.C. ............................................ 32; 33<br />
Gisfre<strong>di</strong> S. ....................................................85<br />
Giubilei F. ....................................................95<br />
Giugliano D..................................................77<br />
Giuliani A............................................ 29; 113<br />
Giuliani D..............33; 35; 54; 55; 56; 58; 103<br />
Giuliani G.....................................................67<br />
Giuliani P. ............................................... 9; 29<br />
Giusti P........................................ 15; 106; 118<br />
Giust<strong>in</strong>i E.S. ...............................................119<br />
Giust<strong>in</strong>o A........................................... 93; 108<br />
Gobbi S. .......................................................89<br />
Goffi F..........................................................33<br />
Gol<strong>in</strong>o P. ......................................................72<br />
Gomaraschi M............................................130<br />
Gorelli B.......................................................12<br />
Gor<strong>in</strong>i G. ......................................................96<br />
Gorio A. ..................18; 89; 99; 100; 102; 115<br />
Gosmar M. ...................................................25<br />
Goso C..........................................................80<br />
Govoni M. ..................................................122<br />
Govoni S. .................................. 102; 107; 108<br />
Graciotti L....................................................25<br />
Grad<strong>in</strong>i R............................................... 67; 98<br />
Graiani G......................................................80<br />
Grana M. ....................................................133<br />
Granata A. ....................................................84<br />
Grande V....................................................100<br />
Grappi S. ............................................... 44; 93<br />
145<br />
Grassia G. ..................................................110<br />
Greco A..........................................................8<br />
Greco L ..................................................47; 48<br />
Grieco P. ......................................................55<br />
Grieco R.......................................97; 100; 109<br />
Grilli M. .......................................................34<br />
Gr<strong>in</strong>geri A. .........................................117; 132<br />
Grò M.C.......................................................97<br />
Grohmann U. ...............................................70<br />
Grossi M ......................................................50<br />
Guadagn<strong>in</strong>o V............................................114<br />
Guaita E. ................................................61; 62<br />
Guaragni B.................................................122<br />
Guar<strong>in</strong>i S..................... 21; 54; 55; 56; 58; 103<br />
Guar<strong>in</strong>o I....................................................106<br />
Guar<strong>in</strong>o M....................................................51<br />
Guarna M.....................................................32<br />
Guarneri M.....................................................4<br />
Guarneri P......................................................4<br />
Guarneri R. ....................................................4<br />
Guarnieri G. .................................................75<br />
Guerci V.....................................................120<br />
Guerr<strong>in</strong>i G....................................................41<br />
Guerr<strong>in</strong>i R. .......................................15; 31; 56<br />
Guerr<strong>in</strong>i S.....................................................61<br />
Guerr<strong>in</strong>i U..............................................24; 60<br />
Guglielmi F..........................................56; 124<br />
Guglielmotti A.......................................41; 42<br />
Guidarelli A. ..............................101; 119; 124<br />
Guidobono F. ...............................................66<br />
Guidol<strong>in</strong> D. ..........................................15; 106<br />
Gullo A. .....................................................124<br />
Gunella G.............................................56; 112<br />
Gusella M...................................................116<br />
Gusev P.A..................................................108<br />
Habib A......................................................134<br />
Harrison S. .......................................32; 63; 96<br />
Hauser A. ...................................................102<br />
Henson P.M. ..............................................111<br />
Hill K.R........................................................24<br />
Hill M...........................................................43<br />
Humby T....................................................104<br />
Hunter J.C....................................................20<br />
Iacobelli M.................................................119<br />
Iacovelli L..................................29; 33; 95; 98<br />
Iaffaldano G.................................................39<br />
Ialenti A. ............................................110; 112<br />
Ianaro A. ......................................97; 110; 112<br />
Ianniello F....................................................86<br />
Iannone M....................................................40<br />
Iannotta V. .......................... 9; 31; 33; 53; 127
Iavicoli I. ......................................................52<br />
Ibba C.........................................................121<br />
Ibrahim T......................................................25<br />
Ignarro J.L....................................................13<br />
Imbesi M. .....................................................15<br />
Imbimbo B.P. .............................................108<br />
Imbimbo C. ..................................................13<br />
Impagnatiello F. .................................... 39; 58<br />
Impicciatore M.............................. 32; 60; 100<br />
Improta G. ....................................................63<br />
Inderbitz<strong>in</strong> W. ............................................102<br />
Invernizzi W.................................................39<br />
Irace C........................................................103<br />
Iula M.................................................... 33; 95<br />
Iuliano R.......................................................80<br />
Iuvone T. ............................. 71; 100; 111; 130<br />
Izzo A.A................................................ 75; 94<br />
Kasahara J. ...................................................15<br />
Keller F. .....................................................129<br />
Kendrick K.M. ...........................................108<br />
K<strong>in</strong>gston A. ..................................................98<br />
Kitbunnadaj R. .............................................62<br />
Knowles R.G..............................................103<br />
Koch P..........................................................75<br />
L’Episcopo F................................... 4; 47; 100<br />
La Placa M. ..................................................47<br />
La Rana G. .............................................. 6; 94<br />
Labbozzetta M..............................................91<br />
Laghi-Pas<strong>in</strong>i F..............................................54<br />
Lampa E. ......................................................64<br />
Landuzzi D...................................................93<br />
Lanni C.............................................. 102; 107<br />
Lanzi R.........................................................66<br />
Lapane K....................................................118<br />
Lapane K.L...................................................56<br />
Larsen B.D. ..................................................44<br />
Lasala R........................................................50<br />
Lastella M ..................................... 25; 85; 117<br />
Lattanzi R.............................................. 28; 32<br />
Lattuada D....................................... 47; 48; 67<br />
Lattuada N....................................... 66; 67; 76<br />
Lavagno L. .................................................112<br />
Laviola G......................................... 11; 39; 92<br />
Lazzeri G......................................................89<br />
Lecch<strong>in</strong>i S. ................................ 33; 35; 47; 70<br />
Ledda F. .................................... 57; 58; 59; 77<br />
Leggio B.......................................................93<br />
Lembo G. .....................................................92<br />
Lenti L..........................................................98<br />
Leon A............................................................7<br />
Leone R................................................. 19; 51<br />
146<br />
Leone S. ............................ 54; 55; 56; 58; 103<br />
Lesma E. ......................................18; 100; 115<br />
Leter G.........................................................51<br />
Leto G. .........................................................85<br />
Leung E............................................9; 33; 127<br />
Leurs R.........................................................62<br />
Levy-Toledano S. ......................................134<br />
Liantonio A..............................................2; 99<br />
Liberati V...................................................121<br />
Liberatore F. ..................................................5<br />
Libran<strong>di</strong> D......................................................6<br />
Licata S. .....................................................116<br />
Ligresti A.....................................................94<br />
Limonciello V............................................127<br />
L<strong>in</strong>ari G........................................................63<br />
Liperoti R.....................................................56<br />
Lippolis L...............................................12; 55<br />
Locatelli V. ..................................................67<br />
Lodetti B. .........................................23; 24; 60<br />
Lodovici M. .........................................56; 124<br />
Lograno M.D. ..............................................94<br />
Loi F.M.P.....................................................57<br />
Loio<strong>di</strong>ce F......................................................2<br />
Loizzo A. .......................... 6; 57; 67; 106; 122<br />
Loizzo S.............................................106; 122<br />
Lombar<strong>di</strong> A..................................................67<br />
Lombar<strong>di</strong> G....................................46; 70; 104<br />
Lombard<strong>in</strong>i E...............................................50<br />
Lonardo A..................................................119<br />
Lonardo G....................................................65<br />
Longordo F. .................................................29<br />
Loni L. .........................................................84<br />
Lopez L......................................................106<br />
Lorenzoni P..................................................46<br />
Lorusso L.....................................................39<br />
Losi G. ...................................................24; 95<br />
Lubrano W...................................................62<br />
Lucchesi B.R................................................24<br />
Luceri C. ................................................5; 124<br />
Luciani F......................................................93<br />
Luciani S............................................100; 130<br />
Lus<strong>in</strong>i L........................................................60<br />
Lutz B. .........................................................94<br />
Maccari S.........................................34; 58; 59<br />
Maccar<strong>in</strong>elli G. ....................................65; 122<br />
Maccher<strong>in</strong>i M...............................................54<br />
Macchi B....................................................103<br />
Macciocco E. ...............................................96<br />
Macianskiene R. ..........................................59<br />
Madaschi L. ...........................18; 99; 100; 102<br />
Maffia P. ....................... 12; 75; 110; 112; 130
Maggi A. ......................................................21<br />
Maggi C.A....................................................80<br />
Maggioni A.P...............................................82<br />
Magnani M.................................................111<br />
Magnan<strong>in</strong>i F. ................................................32<br />
Maione S. ........................................ 15; 17; 37<br />
Maior<strong>in</strong>o M. ...............................................133<br />
Maiuri M.C...................................... 47; 48; 71<br />
Maj M.................................................... 7; 102<br />
Malmberg-Aiello P. ................................ 2; 41<br />
Malori W....................................................113<br />
Malorni W............................................... 9; 50<br />
Malusà N......................................................61<br />
Manconi M...................................................96<br />
Mancuso L....................................................96<br />
Manfre<strong>di</strong> V...................................................25<br />
Manfred<strong>in</strong>i R................................................53<br />
Mangano G...................................................31<br />
Mangieri M. .................................................98<br />
Mania G........................................................59<br />
Mannaioni P.F........................... 49; 50; 70; 92<br />
Mannari C ........................................... 64; 116<br />
Mannucci C..................... 16; 21; 94; 108; 119<br />
Mannucci P.M............................................117<br />
Manopulo R................................................116<br />
Mantegazza P. ............................................106<br />
Mantovani A. ...............................................55<br />
Mantovani L.G.......................... 117; 118; 132<br />
Manz<strong>in</strong>i S .....................................................80<br />
Marabese I............................................. 15; 37<br />
Marani L.......................................................36<br />
Marasciulo F.L...................................... 21; 67<br />
Marcantoni A. ..............................................65<br />
Marchesi M. .................................................24<br />
Marchetti B. .................................... 4; 47; 100<br />
Marchetti C. .................................................70<br />
Marchi M............................................... 34; 61<br />
Marchi S.......................................................63<br />
Marchioli R. .................................................82<br />
Marciano M.C. .............................................21<br />
Marcoli M. .......................................... 23; 101<br />
Marcozzi G.................................................121<br />
Marcuzzi A...................................................48<br />
Marelli O............................................... 47; 48<br />
Maremmani I................................................78<br />
Marfella R. ...................................................77<br />
Mariani L............................................... 15; 37<br />
Marigliano N..............................................114<br />
Mar<strong>in</strong>elli F..................................................101<br />
Mar<strong>in</strong>i H.21; 58; 59; 60; 61; 66; 68; 75; 108;<br />
124<br />
147<br />
Mar<strong>in</strong>i R.......................................................66<br />
Mar<strong>in</strong>o F. ...............................................47; 70<br />
Mar<strong>in</strong>o S. .....................................................36<br />
Mar<strong>in</strong>ovich M. ...............................................3<br />
Marra C..................................................59; 96<br />
Marra R..............................................5; 40; 44<br />
Marras C. .....................................................84<br />
Marrelli D. ...................................................84<br />
Marrocco G..................................................64<br />
Marrosu G..................................................102<br />
Marsicano G.................................................94<br />
Marsico S.A. ................................................63<br />
Martarelli B................................................127<br />
Martarelli D. ..............................................127<br />
Martella L. ...................................................25<br />
Martelli A.............................................16; 118<br />
Martelossi S. ................................................61<br />
Mart<strong>in</strong>elli C..................................................93<br />
Mart<strong>in</strong>ez V...................................................57<br />
Mart<strong>in</strong>i C......................................................41<br />
Mart<strong>in</strong>i F. .....................................................98<br />
Mart<strong>in</strong>oli L...................................................50<br />
Mart<strong>in</strong>otti E......................................57; 63; 93<br />
Martire A .....................................................97<br />
Martire M.....................................................38<br />
Martocchia A. ............................................120<br />
Martucci C. ..................................................70<br />
Martuscelli P................................................21<br />
Marzani B. .................................................121<br />
Marzatico F................................................121<br />
Marzocca C............................................49; 70<br />
Marzocchi N ..............................................116<br />
Marzocco S. .................... 12; 13; 55; 113; 131<br />
Marzola G. ...................................................15<br />
Marzullo A.................................................113<br />
Mascia M.P..................................................96<br />
Mascolo N..............................................75; 94<br />
Maselli R......................................................63<br />
Masi F. .........................................................44<br />
Mas<strong>in</strong>i E...................................49; 70; 92; 110<br />
Massa A. ......................................................80<br />
Massetti M. ................................................113<br />
Massi M. ................................................39; 93<br />
Mast<strong>in</strong>o A. .................................................103<br />
Matarrese P. ...........................................9; 113<br />
Matrisciano F...............................................66<br />
Matrone C. .........................................103; 123<br />
Mattace Raso G................................47; 48; 66<br />
Matteoli M. ............................................10; 36<br />
Mattera G.G. ........................................57; 131<br />
Matteucci G. ........................................64; 106
Mattioli B. ....................................................47<br />
Mattioli F......................................................25<br />
Maucci C......................................................58<br />
Maucci R....................................................122<br />
Maura G. ............................................. 23; 101<br />
Mazzanti G...................................................57<br />
Mazzei T. .....................................................14<br />
Mazzeo F......................................................86<br />
Mazzetti L. ...................................... 55; 56; 63<br />
Mazzi U......................................................128<br />
Mazzola A......................................................9<br />
Mazzola C. .....................................................6<br />
Mazzon E. ....................................... 48; 55; 67<br />
Mazzoni E. ............................................ 23; 50<br />
Mazzucchelli M..........................................107<br />
Mazzuferi M.................................................37<br />
Me<strong>in</strong>i A. .......................................................90<br />
Melani A. .......................................................9<br />
Melchiorri D.17; 29; 33; 34; 40; 66; 95; 96;<br />
97; 98; 101; 102; 103<br />
Melchiorri P. ................................... 28; 32; 75<br />
Meldolesi J. ................................................102<br />
Mele A..........................................................30<br />
Meli E.................................................. 17; 123<br />
Meli R. ............................................ 47; 48; 66<br />
Melosi A.......................................................84<br />
Memo M.................... 102; 106; 107; 109; 129<br />
Men<strong>di</strong>c<strong>in</strong>o A. ...............................................68<br />
Meneghelli G..............................................119<br />
Meneghelli I. ................................................19<br />
Menna P. ............................................. 80; 124<br />
Menn<strong>in</strong>i T...................................................125<br />
Menozzi A....................................................62<br />
Mercanti D. ................................................101<br />
Mercuri N.....................................................99<br />
Mereghetti I................................................125<br />
Mereu G. ........................................................6<br />
Merighi S............................. 9; 31; 33; 53; 127<br />
Mess<strong>in</strong>a G. ...................................................50<br />
Mey V. .................................................. 84; 85<br />
Micale V.........................................................6<br />
Micali A. ....................................................117<br />
Micheli L...........31; 41; 47; 81; 113; 115; 133<br />
Miele E...........................................................4<br />
Miele E............................................ 5; 36; 101<br />
Miele M............................................... 36; 101<br />
Migheli R. ................................... 4; 5; 36; 101<br />
Miglio G.............................................. 70; 104<br />
Miglioli P.A. ................................................86<br />
Migliorati G..................................................99<br />
Migliori M........................................... 64; 116<br />
148<br />
Milanese C...................................................31<br />
Milanese M. ...............................................125<br />
Milani S. ......................................................84<br />
Milano W...................................31; 41; 68; 94<br />
M<strong>in</strong>ar<strong>di</strong> M..................................................120<br />
M<strong>in</strong>i E. .....................................................8; 14<br />
M<strong>in</strong>ici C.......................................................21<br />
M<strong>in</strong>otti G. ............................................80; 124<br />
M<strong>in</strong>utoli L......................... 61; 66; 68; 75; 124<br />
Miolo N......................................................118<br />
Mioni C............................. 54; 55; 56; 58; 103<br />
Mirabella G..................................................64<br />
Miraglia del Giu<strong>di</strong>ce E...........................37; 38<br />
Mirandola P. ..............................................127<br />
Mirone V......................................................13<br />
Missale C. ..................................................120<br />
Mitola S. ......................................................22<br />
Mitolo C.I. .................................................113<br />
Mitolo Chieppa D. .......... 21; 54; 67; 113; 120<br />
Mitro N. .......................................................22<br />
Mladenka P. ...............................................102<br />
Ml<strong>in</strong>ar B.........................................................2<br />
Mocell<strong>in</strong> M. .................................................70<br />
Modugno G..................................................15<br />
Mognetti B.................................112; 122; 127<br />
Molf<strong>in</strong>o F.....................................................34<br />
Mol<strong>in</strong>aro P. ................................................103<br />
Mollica M. ...................................................16<br />
Mondello L. ...............................................112<br />
Mond<strong>in</strong>o C...................................................75<br />
Monetti M. .............................................21; 22<br />
Monopoli A............................23; 58; 101; 122<br />
Montagnani M. ..............................21; 67; 120<br />
Montalto G...................................................91<br />
Montanaro N................................................19<br />
Monteleone P.................................................7<br />
Monti E. .................................................80; 90<br />
Montuschi P.................................................75<br />
Monz<strong>in</strong>i M.S..............................................117<br />
Morabito D.................................................112<br />
Moraitis C. ...................................................33<br />
Morale M.C......................................4; 47; 100<br />
Moraschi S...................................................15<br />
Morbidelli L...................................58; 60; 130<br />
Moreci W...............................................41; 42<br />
Morelli A. ..................................................133<br />
Morelli M...............................................83; 92<br />
Morello S. ............................................75; 111<br />
Mores N. ......................................................66<br />
Moretti S. ...................................................119<br />
Moretti U. ....................................................19
Mor<strong>in</strong>i M......................................................90<br />
Morisco C.....................................................77<br />
Moro E. ........................................................33<br />
Moroni F. ...................................................123<br />
Morrone L.A. ...................................... 38; 103<br />
Mosca M. .....................................................55<br />
Moschetta A. ..............................................113<br />
Moscianese K...............................................68<br />
Mosconi L. ...................................................28<br />
Mostall<strong>in</strong>o M.C. ............................ 93; 96; 121<br />
Motola D. .....................................................19<br />
Motolese M. ........................................ 29; 102<br />
Mozzo F. ......................................................19<br />
Mrak E..........................................................66<br />
Mubagwa K..................................................59<br />
Muccioli G. ............................... 51; 65; 81; 88<br />
Mudò G. .......................................................43<br />
Mugelli A. .........56; 58; 65; 82; 115; 116; 130<br />
Muller E.E........................................... 67; 121<br />
Mumolo M.G. ..............................................63<br />
Mumolo S.....................................................86<br />
Muntoni E. .................................... 18; 88; 115<br />
Mura M. P ....................................... 5; 36; 101<br />
Murgia V....................................................119<br />
Murphy R.C. ..................................... 111; 112<br />
Mussoni L. ............................................ 54; 60<br />
Muzz<strong>in</strong> S. .....................................................25<br />
Nabissi M. ..................................................127<br />
Nacci C.................................................. 21; 67<br />
Nall M.I........................................................46<br />
Nanni G........................................................44<br />
Nar<strong>di</strong> M........................................................85<br />
Nargi E. ................................................. 29; 33<br />
Nascetti S. ..................................................121<br />
Nascimben E. ........................................ 86; 87<br />
Nasti A. ........................................................66<br />
Nasti C..........................................................12<br />
Nastri G........................................................84<br />
Natale G. ......................................................62<br />
Natale L......................................................113<br />
Navarra M. ...................................................23<br />
Navarra P......................................... 48; 66; 68<br />
Nazzicone V........................................ 97; 109<br />
Nebbia C. .....................................................91<br />
Negri L. ..................................... 20; 28; 32; 75<br />
Negro A......................................................106<br />
Nenc<strong>in</strong>i C. ...........31; 47; 62; 81; 84; 113; 133<br />
Nenc<strong>in</strong>i P........................................... 6; 78; 92<br />
Neri D...........................................................50<br />
Netti C................................................... 65; 67<br />
Ngomba R.T.................................................34<br />
149<br />
Nicolai R................................................28; 40<br />
Nicoletti F.9; 17; 29; 33; 34; 40; 42; 66; 67;<br />
92; 95; 96; 97; 98; 99; 101; 102; 103; 104<br />
Nicoletti P. ...................................................96<br />
Nicol<strong>in</strong> A. ....................................................14<br />
Nicolussi E...................................................44<br />
Nieddu E. .....................................................36<br />
Nieri P..............................................57; 63; 93<br />
Nizzari M...................................4; 28; 95; 108<br />
Nocent<strong>in</strong>i G............................................70; 71<br />
Noonan D.....................................................90<br />
Notarbartolo M ............................................91<br />
Novell<strong>in</strong>i R...................................................55<br />
Novell<strong>in</strong>o E..................................................55<br />
Noviello S. ...................................................86<br />
Nunziata A...................................................93<br />
Nuzzo I.........................................................48<br />
Oberto G. ...................................................125<br />
Oleszek W..................................................113<br />
Oliva L.........................................................99<br />
Oliva P. ........................................................15<br />
Olivieri K...................................................108<br />
Olson M.F..................................................133<br />
Ongali B.......................................................37<br />
Ong<strong>in</strong>i E.................... 23; 39; 58; 83; 101; 122<br />
Orabona C....................................................70<br />
Origlia N. .............................................64; 116<br />
Orlan<strong>di</strong> P......................................................85<br />
Orlando R...............................................18; 59<br />
Orrù A..........................................................96<br />
Orrù M. ....................................................2; 40<br />
Orsetti M............................................106; 107<br />
Orsol<strong>in</strong>i E.....................................................51<br />
Ortolani F.....................................................38<br />
Orzi F...........................................................95<br />
Osella D. ......................................................89<br />
Ossola P. ......................................................26<br />
Ottani A. ................................47; 89; 111; 115<br />
Oveisi F..........................................................7<br />
Paccioretti S.......................................106; 109<br />
Pacifici L........................................46; 57; 131<br />
Pacilio M..........................................47; 48; 66<br />
Pac<strong>in</strong>i A. ......................................................28<br />
Pacor S.................................................90; 128<br />
Padr<strong>in</strong>i R. .....................................18; 116; 117<br />
Pagani F. ................................................66; 76<br />
Pagano S. .............................................97; 104<br />
Pagn<strong>in</strong> E.................................................54; 57<br />
Pala P. ..........................................................92<br />
Palasciano G. .............................................113<br />
Palat<strong>in</strong>i P......................................................18
Palazzo E......................................................37<br />
Palla R........................................................116<br />
Pallanti S. .....................................................27<br />
Palma E ........................................................44<br />
Palmery M....................................................59<br />
Palmi C.........................................................90<br />
Palmieri C. ............................................ 10; 33<br />
Palmieri S.....................................................13<br />
Palomba D....................................................51<br />
Palomba L. .................................................111<br />
Palù G...........................................................14<br />
Palu<strong>di</strong> D................................................. 4; 104<br />
Palumbo G........................................... 62; 116<br />
Palumbo P. ...................................................62<br />
Pancal<strong>di</strong> C. ....................9; 31; 33; 53; 54; 127<br />
Panerai A.E. ............................................ 6; 70<br />
Pani P.P:.......................................................78<br />
Panichi V............................................. 64; 116<br />
Pann<strong>in</strong>i S. .............................................. 51; 86<br />
Panourgia M.P............................................121<br />
Pansarasa O................................................121<br />
Pantaleoni G...............................................116<br />
Pantaleoni P................................................116<br />
Paola R. ............................................... 58; 130<br />
Paoletti R......................................................21<br />
Paoletti R......................................... 24; 72; 82<br />
Paol<strong>in</strong>i M......................................................66<br />
Paparelli A....................................................89<br />
Papasso A.....................................................31<br />
Pap<strong>in</strong>i M.G.................................................104<br />
Papotti M............................................... 81; 88<br />
Parati E................................................ 97; 104<br />
Paratore S. ....................................................89<br />
Parente L. ........................ 21; 31; 53; 103; 110<br />
Parenti A. .................................. 57; 58; 59; 77<br />
Parenti C.......................................................95<br />
Parenti G. .....................................................85<br />
Parenti M......................................................96<br />
Parenzan K. ..................................................48<br />
Parisi S. ........................................................80<br />
Paro<strong>di</strong> M.......................................................34<br />
Paro<strong>di</strong> S......................................................107<br />
Parolaro D. .....................................................6<br />
Parsi S. ...........................................................2<br />
Pascale A....................................................108<br />
Pasciullo G. ................................................115<br />
Pascotto A. ............................................ 37; 38<br />
Pasero E........................................................18<br />
Pas<strong>in</strong>i P.........................................................62<br />
Pasqual E......................................................25<br />
Passalacqua M..............................................37<br />
150<br />
Passaniti M...................... 54; 61; 68; 108; 124<br />
Passarelli F...................................................97<br />
Passarello F................................................115<br />
Pastore F. .....................................................53<br />
Pastoris O.....................................................63<br />
Patel N.S.A. ...........................................48; 97<br />
Patricelli P................................................9; 29<br />
Patrignani P............. 18; 25; 47; 110; 126; 133<br />
Patrono C. ............................................18; 126<br />
Pattarozzi A. ........................................80; 120<br />
Pau A. ..........................................................96<br />
Pavan F. .....................................18; 46; 86; 87<br />
Pavone F ......................................................41<br />
Pazzagli M. ....................................................2<br />
Pea F. ...............................................18; 86; 87<br />
Peana A.T. ...................................................36<br />
Pecorari M. ................................................125<br />
Pedata F. ..................................................9; 43<br />
Pe<strong>di</strong>coni D. ................................................127<br />
Pedone C..............................................56; 118<br />
Pedrazzo G.................................................106<br />
Pedro E.......................................................120<br />
Pegor<strong>in</strong>i S.....................................................23<br />
Pelaia G................................................63; 114<br />
Pellegr<strong>in</strong>i-Giampietro D. ...........................123<br />
Pellicciari R. ................................................33<br />
Pellizzaro C................................................128<br />
Peluso I. .......................................................59<br />
Pengo V. ......................................................18<br />
Pennisi G......................................................59<br />
Pepeu G........................................2; 5; 83; 107<br />
Pepicelli O. ............................................29; 38<br />
Pepponi R.........................................4; 97; 109<br />
Perbell<strong>in</strong>i A................................................128<br />
Periss<strong>in</strong> L. ..............................................38; 81<br />
Peroglio F.....................................................26<br />
Perone V. ...................................................119<br />
Peroni A.......................................................64<br />
Perri R........................................................103<br />
Perrotta D.....................................................58<br />
Persich<strong>in</strong>i T................................................111<br />
Perticone G. .................................................59<br />
Perucca E. ....................................................74<br />
Pesce E.......................................................127<br />
Pess<strong>in</strong>a A.C............................................54; 57<br />
Pess<strong>in</strong>a F. ...............................................12; 64<br />
Pess<strong>in</strong>a G.P. .................................................90<br />
Petersen J.S..................................................44<br />
Peticca M. ..................................................130<br />
Petraglia F....................................................81<br />
Petrella A. ..................................................103
Petrella C................................... 31; 41; 68; 94<br />
Petrelli L.......................................................38<br />
Petri A. .........................................................64<br />
Petrioli R. .....................................................86<br />
Petron<strong>in</strong>i P.G..............................................124<br />
Petrucci R...................................................102<br />
Pèzzola A. ......................................... 100; 109<br />
Pezzola P....................................................108<br />
Pezzotti G.....................................................64<br />
Piacente S...................................................113<br />
Piacent<strong>in</strong>i N................................................119<br />
Piazzetta V. ..................................................19<br />
Piazzi L. .......................................................89<br />
Picascia A.....................................................33<br />
Picciolo M....................................................93<br />
Piccirilli S...................................................103<br />
Piccoli F. ........................................................4<br />
Piccoli P. ......................................................18<br />
Picollo A. .......................................................2<br />
Piegari E.......................................................65<br />
Piepoli A.L.................................................113<br />
Pieretti S.............................................. 41; 112<br />
Pierno S............................................. 2; 65; 99<br />
Pierpaoli S....................................... 49; 70; 92<br />
Pietra C.......................................................133<br />
Pietropaolo C..............................................130<br />
Pigh<strong>in</strong> I.......................................................100<br />
Pignataro G. ...................................... 103; 105<br />
P<strong>in</strong>i L.A....................................... 46; 116; 133<br />
P<strong>in</strong>na A.........................................................92<br />
P<strong>in</strong>to A. ........................... 12; 13; 55; 113; 131<br />
P<strong>in</strong>to E..........................................................84<br />
P<strong>in</strong>ton P......................................................133<br />
P<strong>in</strong>tor A....................................... 97; 100; 109<br />
Piomelli D. ............................................ 1; 6; 7<br />
Pippia P. .......................................................36<br />
Pirani P............................................ 80; 90; 91<br />
Piredda M...................................................121<br />
Piris<strong>in</strong>o R......................................... 56; 65; 68<br />
Pirritano D........................................... 85; 114<br />
Pirro E. .............................................. 122; 127<br />
Pisano B. ......................................................97<br />
Pisoni I. ........................................................51<br />
Pistritto G. ........................................... 47; 133<br />
Pisu M.G. .....................................................94<br />
Pittaluga A....................................... 17; 29; 34<br />
Pizza C. ......................................................113<br />
Pizzi M. ............................................... 33; 123<br />
Pizz<strong>in</strong>ga A..................................................121<br />
Pizzirani C..................................................133<br />
Platania M. .................................................134<br />
151<br />
Platania P. ....................................................99<br />
Podda E........................................................90<br />
Poggioli R. ...........................................41; 114<br />
Pola S.....................................................53; 88<br />
Polenzani L. .................................................31<br />
Poli A.....................................................29; 99<br />
Poli E. ..........................................................62<br />
Poli G...........................................55; 106; 122<br />
Polidori C.....................................................93<br />
Polimeni G.........................................117; 119<br />
Politi A.........................................................48<br />
Pollera C. ...................................................106<br />
Pollo B. ........................................................84<br />
Poma P.........................................................91<br />
Pompei, P...................................................127<br />
Pons N....................................................51; 65<br />
Pontarelli F.................................................104<br />
Ponti W. .....................................................106<br />
Popoli M. .........................................15; 43; 69<br />
Popoli P........................... 4; 97; 100; 108; 109<br />
Popolo A. ...............................................12; 13<br />
Porcile C. ...............................................90; 91<br />
Porcu P.......................................................121<br />
Porrello E...................................................107<br />
Porro C...................................................21; 67<br />
Portaleone P.................................................45<br />
Portaluppi F. ................................................53<br />
Port<strong>in</strong>casa P. ..............................................113<br />
Posadas I. .....................................................75<br />
Potenza G.....................................................66<br />
Potenza M.A. .........................................21; 67<br />
Potenza R.L..............................................4; 97<br />
Pozzetti L.....................................................66<br />
Pozzilli C. ..................................................101<br />
Pozzoli C......................................................62<br />
Pozzoli G. ..............................................48; 68<br />
Prantera T.....................................................85<br />
Pravettoni E. ................................................10<br />
Preda S.......................................................108<br />
Presotto C.......................................39; 58; 122<br />
Prete S.P.....................................................113<br />
Primavera L.G..............................................62<br />
Procopio A...................................................25<br />
Proietti A......................................................48<br />
Prosperi C. .............................................5; 107<br />
Puccetti P. ....................................................70<br />
Puggioli C. .................................................116<br />
Pugliese A.M. ................................................9<br />
Puglisi C.....................................................100<br />
Puglisi L.......................................................21<br />
Pugnaloni A. ................................................48
Puia G.................................................... 24; 95<br />
Puopolo M..................................................107<br />
Pusch M..........................................................2<br />
Quaranta M.G...............................................47<br />
Quattrone A. ........................................ 68; 108<br />
Qu<strong>in</strong>tieri L....................................................89<br />
Quitadamo M.C............................................37<br />
Quon M.J....................................................120<br />
Racagni G.................................. 15; 27; 43; 69<br />
Racca S.................................................. 45; 91<br />
Racchi M............................. 83; 102; 104; 107<br />
Rae G.A........................................................15<br />
Raffaele M....................................................85<br />
Ragni G. .....................................................117<br />
Raimon<strong>di</strong> L. .................................... 56; 65; 68<br />
Raiteri L. ......................................... 29; 37; 99<br />
Raiteri M. ........17; 23; 29; 34; 37; 38; 99; 101<br />
Rakovska A....................................................2<br />
Rampa A. .....................................................89<br />
Rapetti D. ........................................ 66; 67; 76<br />
Rappelli L.....................................................63<br />
Ras<strong>in</strong>i E................................................. 47; 70<br />
Rathbone M.P...............................................29<br />
Rauggi R. .....................................................28<br />
Rausa L. .......................................................26<br />
Ravasi S....................................... 96; 111; 134<br />
Ravera M......................................................89<br />
Ravera S. ....................................................117<br />
Ravizza R. ............................................. 80; 90<br />
Razzetti R.....................................................53<br />
Rebuzzi A...................................................110<br />
Recchia A...................................................106<br />
Reggiani A. ..................................... 20; 43; 44<br />
Reggio R. .................................. 100; 108; 109<br />
Regoli D. ............................. 15; 31; 37; 44; 56<br />
Reitano E....................................................104<br />
Remelli R. ....................................................43<br />
Renda G......................................................110<br />
Renzi P. ........................................................67<br />
Repetto E................................... 4; 28; 95; 108<br />
Riccar<strong>di</strong> C. ........................ 18; 70; 71; 99; 113<br />
Ricci L........................................................107<br />
Ricci Vitiani L..............................................97<br />
Ricciar<strong>di</strong> R. ................................................103<br />
Riccio L......................................................116<br />
Riccio M.......................................................36<br />
Ricciotti E. .......................................... 47; 133<br />
Richards D....................................................38<br />
Richelmi P............................................. 50; 98<br />
Rigamonti A.E. ................................... 67; 121<br />
Rigamonti D........................................ 95; 104<br />
152<br />
Righetto V..............................................10; 29<br />
Rigoni M......................................................32<br />
R<strong>in</strong>al<strong>di</strong> B......................................................59<br />
R<strong>in</strong><strong>di</strong> P. ......................................................116<br />
Riozzi B. ......................................................67<br />
Rispoli V........................................................5<br />
Risso F. ........................................................34<br />
Riunno M.....................................................53<br />
Rivasi M.......................................................40<br />
Rizzato S......................................................57<br />
Rizzi A...................................................44; 56<br />
Rizzi D.........................................................31<br />
Rizzuto R. ..................................................133<br />
Robbiano L. ...............................................124<br />
Rocca B......................................................126<br />
Roccatagliata M.G. ......................................16<br />
Roccatagliata P. ...........................................23<br />
Rocchitta G. .................................4; 5; 36; 101<br />
Roda A. ........................................................62<br />
Ro<strong>di</strong> D..........................................................37<br />
Rodríguez de Fonseca F.................................7<br />
Rolfo K. .....................................................125<br />
Rolland J-F...................................................65<br />
Romagnoli R................................................33<br />
Romano Carratelli C....................................48<br />
Romano M.R................................................94<br />
Rombolà L. ..........................................38; 103<br />
Romual<strong>di</strong> P. ...........................................36; 93<br />
Ronchetti S.............................................70; 71<br />
Ronda N.......................................................21<br />
Rosati A. ..............................................90; 121<br />
Rosenberg E.................................................89<br />
Rossetti F. ..................................................118<br />
Rossi A.......................................110; 111; 112<br />
Rossi D.........................................................98<br />
Rossi F. ........... 15; 37; 59; 64; 65; 72; 86; 121<br />
Rossi M........................................................81<br />
Rossi Pr<strong>in</strong>cipe D. ...................................4; 104<br />
Rossi T...........................................46; 86; 107<br />
Ross<strong>in</strong> R.....................................................128<br />
Rossoni G...................................................130<br />
Rosti G...........................................................8<br />
Rothblat G.H................................................21<br />
Rotiroti D...........................................5; 40; 88<br />
Rovati G.E. ..................................96; 111; 134<br />
Roviello F. ...................................................84<br />
Roviezzo F.................................21; 31; 53; 75<br />
Rozza A. ....................................................108<br />
Ruberto I.A. .........................................86; 107<br />
Rub<strong>in</strong>acci A. ................................................66<br />
Rub<strong>in</strong>i C.......................................................48
Rub<strong>in</strong>o T. .......................................................6<br />
Ruffo P.F....................................................118<br />
Ruf<strong>in</strong>i S. .......................................................50<br />
Ruggeri F............................................. 65; 122<br />
Ruggiero V...................................................46<br />
Runci F.M. ...................................... 51; 62; 86<br />
Russo A............................................. 119; 130<br />
Russo C. .................................... 4; 28; 95; 108<br />
Russo D................................................... 4; 88<br />
Russo E ..................................... 3; 44; 45; 114<br />
Russo G......................................................130<br />
Russo P.............................. 116; 118; 119; 132<br />
Russo R. ............................................ 6; 23; 94<br />
Sabat<strong>in</strong>i V.......................................................1<br />
Sabat<strong>in</strong>o C................................. 31; 41; 68; 94<br />
Sab<strong>in</strong>o V.........................................................6<br />
Sacco G ........................................................80<br />
Sacerdote P............................................ 65; 70<br />
Saettone M.F. .............................................115<br />
Saggese M....................................................53<br />
Saia A.........................................................100<br />
Sala A.................................... 54; 59; 111; 112<br />
Sala M. ................................................ 23; 106<br />
Salis S........................................ 4; 28; 95; 108<br />
Salmaggi A...................................................84<br />
Salomone S. .......................................... 44; 59<br />
Salt<strong>in</strong>i S......................................... 47; 89; 111<br />
Salvadori A. .................................................57<br />
Salvadori S. ........................................... 15; 31<br />
Salvato C....................................................118<br />
Salvatorelli E....................................... 80; 124<br />
Salvatori S....................................................56<br />
Salvem<strong>in</strong>i D........................................... 49; 55<br />
Salvi L..........................................................54<br />
Salvo F. ......................................................119<br />
Sampaio C......................................................1<br />
Sances G.....................................................115<br />
Sancesario G. .................................................9<br />
Sandr<strong>in</strong>i M................................................133<br />
Sangiorgi Z.................................................120<br />
Sanguedolce R..............................................26<br />
Sanna E. ................................................ 93; 96<br />
Santavenere C. ........................................ 9; 29<br />
Santi S. .........................................................36<br />
Santillo M.R.................................................51<br />
Sant<strong>in</strong>i C.....................................................113<br />
Santoro A. ....................................................58<br />
Santoro M.G...................................... 110; 112<br />
Santus P......................................................100<br />
Sanz J.M.....................................................133<br />
Saponara S............................................. 12; 13<br />
153<br />
Sapone A......................................................66<br />
Saragoni S..................................................119<br />
Sarnelli G.....................................................61<br />
Sarnico I.......................................................33<br />
Sartiani L. ......................................56; 58; 130<br />
Sartor F. .......................................................25<br />
Sartori M.L. .................................................91<br />
Saso L. .......................................................102<br />
Satta M.........................................................51<br />
Saulle E......................................................123<br />
Sauteb<strong>in</strong> L..................................110; 111; 112<br />
Sava G......................... 12; 48; 88; 89; 90; 128<br />
Savar<strong>in</strong>o G ...................................................84<br />
Sav<strong>in</strong>o C.....................................................122<br />
Sav<strong>in</strong>o G. ...................................................115<br />
Savoca F.......................................................59<br />
Scaccianoce S. .......................................42; 66<br />
Scaggiante B. .........................................38; 81<br />
Scali C....................................................5; 107<br />
Scalone L. ..................................................117<br />
Scannav<strong>in</strong>i P. ...............................................46<br />
Scanniffio D.................................................67<br />
Scarcia V......................................................90<br />
Scarpignato C...............................................79<br />
Scattoni M.L. .............................................108<br />
Scheggi S. ....................................................28<br />
Schenk U......................................................10<br />
Schett<strong>in</strong>i G.4; 15; 28; 80; 90; 91; 95; 104;<br />
108; 120; 129<br />
Schiöth H.B................................................103<br />
Schulz R.......................................................60<br />
Schwarz M...................................................64<br />
Sciacca F......................................................84<br />
Scipione L......................................................5<br />
Sciulli M.G. ...........................25; 47; 110; 133<br />
Scordo M.G..........................................18; 115<br />
Scorziello A. ........................................51; 103<br />
Scoto G.............................................4; 47; 100<br />
Scotto <strong>di</strong> Mase G. ........................................15<br />
Scotton P.G..................................................86<br />
Scurti M. ....................................................121<br />
Secondo A....................................................51<br />
Segant<strong>in</strong>i D. .................................................34<br />
Selvatici R....................................................46<br />
Semboloni P.G.............................................16<br />
Sem<strong>in</strong>ara G. .................................................99<br />
Sem<strong>in</strong>ara P...............................59; 61; 75; 124<br />
Semplic<strong>in</strong>i A. .........................................54; 57<br />
Seraf<strong>in</strong>o A..................................................101<br />
Serpe L.........................................................88<br />
Serra G.P......................................................93
Serra M.........................................................94<br />
Serra P.A. .................................... 4; 5; 36; 101<br />
Serraglia D. ................................................118<br />
Serra<strong>in</strong>o I.13; 48; 53; 55; 67; 110; 111; 112;<br />
113; 131<br />
Sessa A.......................................................119<br />
Sestili P. ............................................ 101; 124<br />
Seta F............................................................25<br />
Sever<strong>in</strong>i C...................................................101<br />
Sferro C........................................................38<br />
Sgaragli G.P. .............12; 13; 51; 64; 106; 107<br />
Shenk U........................................................36<br />
Shimamura I...............................................120<br />
Sibilia V. ......................................... 65; 66; 76<br />
Sigala S. .............................................. 64; 120<br />
Signor<strong>in</strong>i A...................................................51<br />
Silva F. ................................................ 84; 130<br />
Silvestri L...................................................125<br />
Simeone C....................................................64<br />
Simonato M................................... 28; 37; 133<br />
S<strong>in</strong>iscalchi A. ........................................ 36; 44<br />
S<strong>in</strong>iscalco D. ................................................15<br />
Sipione S. ...................................................104<br />
Sirabella R....................................................51<br />
Siriwardena A. .............................................67<br />
Sironi L. .......................................... 23; 24; 60<br />
Sirtori C.R. .................................... 24; 72; 130<br />
Sisillo E........................................................54<br />
Sogliano C..................................................121<br />
Sola A...........................................................54<br />
Soldovieri M.V.............................................38<br />
Solito E.......................................................103<br />
Sorba G. .......................................................61<br />
Sorrent<strong>in</strong>o L. ....................................... 12; 111<br />
Sorrent<strong>in</strong>o R. ........................... 12; 13; 55; 113<br />
Sorrent<strong>in</strong>o V.................................................46<br />
Sort<strong>in</strong>o M.A. ......................... 44; 99; 103; 104<br />
Sossai P. .......................................................86<br />
Sotgiu M.L. ................................................134<br />
Spaccamiglio A..................................... 45; 91<br />
Spadaro M..................................................112<br />
Spallotta C............................................. 57; 58<br />
Spamp<strong>in</strong>ato S. ........................... 3; 52; 62; 122<br />
Spanò M. ......................................................51<br />
Spano P.F. ..................................... 33; 64; 120<br />
Spaziante R. .................................................80<br />
Spessotto P. ..................................................90<br />
Spiga S. ........................................................93<br />
Sp<strong>in</strong>a E. ............................................... 18; 115<br />
Sp<strong>in</strong>a S. ............................................... 56; 112<br />
Sp<strong>in</strong>icelli S. ..................................................99<br />
154<br />
Sp<strong>in</strong>santi P. ..................................................98<br />
Spisani S. .....................................................46<br />
Sponta A.M..........................................62; 116<br />
Squadrito F.21; 54; 58; 59; 60; 61; 66; 68; 75;<br />
103; 108; 124<br />
St. George-Hyslop P. .....................................5<br />
Stanghell<strong>in</strong>i V ..............................................61<br />
Stasi C..........................................................63<br />
Stasi M.A. ....................................................46<br />
Stati T...........................................................58<br />
Steardo L..............................................6; 7; 18<br />
Stefanoni P...................................................37<br />
Steffan A......................................................25<br />
Sternieri E. .................................................115<br />
Stern<strong>in</strong>i C...................................................100<br />
Stigliani S...............................................37; 99<br />
Stillitano F. ..........................................58; 130<br />
Stirpe F.......................................................124<br />
Stocco G.......................................................61<br />
Stochmal A. ...............................................113<br />
Storto M...................................40; 67; 99; 103<br />
Suzuki H. .....................................................70<br />
Tabrizi M.A. ........................................33; 127<br />
Taccola D.....................................................64<br />
Taccola G.....................................................37<br />
Tacconelli S. ..................................18; 25; 110<br />
Tacconi M.T. .............................................122<br />
Tacconi S. ..................................................103<br />
Taglialatela M....................................2; 37; 38<br />
Tagliamonte A. ......................................28; 44<br />
Tajana G.......................................................71<br />
Talani G. ................................................93; 96<br />
Talon S.........................................................30<br />
Tamaro G...................................................120<br />
Tanganelli S.......................................6; 11; 97<br />
Tan<strong>in</strong>i M. ...................................................127<br />
Taraboletti G................................................58<br />
Tarabra E. ........................................65; 81; 88<br />
Taramasco R. .............................................124<br />
Taras M.G........................................5; 36; 101<br />
Tar<strong>di</strong>ti A.......................................................95<br />
Tar<strong>di</strong>to D................................................15; 43<br />
Tari M. .......................................................119<br />
Tarozzo G. ...................................................43<br />
Tarsitano L...................................................32<br />
Tascedda F.......................................44; 45; 69<br />
Tattoli M. ...........................................6; 39; 93<br />
Taurelli R.....................................................46<br />
Tazza A......................................................119<br />
Tebano M.T. ....................................4; 97; 109<br />
Tedesco F.....................................................46
Ten<strong>di</strong> E.............................................. 115; 116<br />
Terrazzani G...............................................118<br />
Terstappen G.C. .................................. 29; 102<br />
Teruzzi C....................................................117<br />
Testa N. ........................................... 4; 47; 100<br />
Testai L. .......................................................57<br />
Thellung S................................... 90; 104; 120<br />
Thiemermann C............................... 48; 67; 97<br />
Thomas D.R. ................................................43<br />
Timmerman H..............................................62<br />
Tiraboschi E. ......................................... 15; 43<br />
Tirolo C........................................... 4; 47; 100<br />
Tocco S. .....................................................121<br />
Tofani S........................................................26<br />
Toffoli G. .....................................................25<br />
Togna A.R....................................................59<br />
Togna G.I. ....................................................59<br />
Tognol<strong>in</strong>i M. ................................................60<br />
Tomas<strong>in</strong>i M.C. ........................................ 6; 97<br />
Tomass<strong>in</strong>i V. ..............................................101<br />
Tom<strong>in</strong>o C. ......................................................1<br />
Tommas<strong>in</strong>i I. ..............................................101<br />
Ton<strong>in</strong>i M. .................................. 61; 63; 64; 79<br />
Torrente Y....................................................99<br />
Torsello A. ...................................................67<br />
Tortiglione A..............................................105<br />
Tortora G......................................................14<br />
Tortorella P. ...................................................2<br />
Toso E. ............................................ 26; 50; 80<br />
Tra<strong>in</strong>a M.E. ..................................................51<br />
Traniello S....................................................46<br />
Tranquilli S. .................................................96<br />
Travaglione S. ..............................................50<br />
Traversa U......................................... 9; 10; 33<br />
Traverso S. .....................................................2<br />
Tremoli E. .............23; 24; 54; 60; 72; 82; 110<br />
Trespi<strong>di</strong> S. ....................................................66<br />
Trevisani M..................................... 32; 63; 96<br />
Trevisi L.....................................................100<br />
Tricarico D. ..................................................30<br />
Trifirò G. ....................................................119<br />
Trimarco B. ..................................................77<br />
Trimarco V...................................................65<br />
Tr<strong>in</strong>gali G........................................ 48; 66; 68<br />
Trione E......................................................127<br />
Trombetta G. ................................................40<br />
Tronci E........................................................92<br />
Trovato Sal<strong>in</strong>aro A.......................................43<br />
Tuccori M...................................................117<br />
Tumm<strong>in</strong>ello F.M. .........................................85<br />
Turr<strong>in</strong> C......................................................128<br />
155<br />
Turriziani M...............................................113<br />
Uberti D. ....................................102; 106; 109<br />
Ugazio E. .....................................................88<br />
Urbani E.......................................................51<br />
Urciuoli R. ...................................................16<br />
Urna G. ......................................................117<br />
Ursillo A. .....................................................46<br />
Urso R..............................................45; 84; 86<br />
Utrilla P........................................................71<br />
Vacca C............................................15; 37; 70<br />
Vadori M..................................10; 12; 29; 128<br />
Vaglia A.......................................................86<br />
Vairano M....................................................48<br />
Vairetti M...............................................50; 98<br />
Valanzano A. .....................................107; 108<br />
Valdembri D. ...............................................22<br />
Valenti M...........................................6; 7; 112<br />
Valenti P. .....................................................89<br />
Valent<strong>in</strong>i G.....................................................6<br />
Valenza M..................................................104<br />
Valerio A .....................................................33<br />
Valori C. ......................................................98<br />
Valoti M.......................................51; 106; 107<br />
Valsecchi V................................................103<br />
Vandone A...................................................85<br />
Vannacci A. .....................................49; 70; 92<br />
Vannozzi F.....................................25; 85; 117<br />
Vannucchi M.G..............................................9<br />
Varani K........................ 9; 31; 33; 53; 54; 127<br />
Varoni MV...................................................51<br />
Varsal<strong>di</strong> F.............................................70; 104<br />
Vas<strong>in</strong>a V ......................................................63<br />
Vassalle C. ...................................................62<br />
Vecchio I......................................................40<br />
Veglia F. ......................................................54<br />
Vella S. ..............................................127; 128<br />
Vellecco V. ................................................111<br />
Velo G.P. .....................................................19<br />
Veltri A. .............................................111; 134<br />
Venegoni M. ................................................19<br />
Venerosi A...........................................41; 107<br />
Venezia V. .................................4; 28; 95; 108<br />
Ventura A.............................................61; 121<br />
Verderio C. ..................................................10<br />
Vergura R.....................................................56<br />
Verotta L......................................................22<br />
Verri M. .......................................................63<br />
Vertechy M. .................................................40<br />
Vezzal<strong>in</strong>i F...................................................40<br />
Vezzani A. .....................................................3<br />
Viano I. ............................. 56; 80; 85; 89; 112
Viappiani S...................................................59<br />
Vicent<strong>in</strong>i L.M........................................ 53; 88<br />
Viganò D........................................................6<br />
Villa I. ..........................................................66<br />
Villa V............................................. 4; 90; 104<br />
Villani L. ......................................................99<br />
Villetti G. .......................................... 108; 133<br />
V<strong>in</strong>ci M.C...................................................100<br />
V<strong>in</strong>et J. .........................................................44<br />
Viora M........................................................47<br />
Virlos I. ........................................................67<br />
Visent<strong>in</strong> B. .................................................100<br />
Vis<strong>in</strong>i D................................................... 9; 29<br />
Visioli F........................................................56<br />
Vita F............................................................90<br />
Vitale G..................................... 114; 125; 133<br />
Vitale R. .......................................................85<br />
Vitali E. ........................................................54<br />
Vitelli M.R. ..................................................65<br />
Vitiello M.....................................................31<br />
Viviani B........................................................3<br />
Vizz<strong>in</strong>i L. .....................................................85<br />
Vojnovic D...................................................48<br />
Volontè C. ............................................... 9; 54<br />
Voltattorni M................................................97<br />
Volterra A. ...................................................98<br />
Von Eckardste<strong>in</strong> A.....................................130<br />
Watson J.M. .................................................43<br />
Werstiuk E....................................................29<br />
Wiesenfeld-Hall<strong>in</strong> Z.....................................39<br />
Wilk<strong>in</strong>son L................................................104<br />
156<br />
Xu X-J..........................................................39<br />
Yokota T. .....................................................98<br />
Yu P. ..........................................................125<br />
Zabucchi G...................................................90<br />
Zaffani S. ...................................................119<br />
Zaffaroni M..................................................70<br />
Zaffe D.................................................55; 103<br />
Zaghetto F..............................................54; 57<br />
Zagli G.............................................49; 70; 92<br />
Zamori C......................................................68<br />
Zampiron A..................................................89<br />
Zanca A........................................................86<br />
Zandomeneghi G. ................................86; 107<br />
Zanetti E.................................................33; 35<br />
Zanoli P........................................................40<br />
Zanotti I. ......................................................21<br />
Zappett<strong>in</strong>i S............................................37; 99<br />
Zara G.P.........................................18; 88; 115<br />
Ziche M..........................................58; 60; 130<br />
Zilletti L.................................................56; 63<br />
Zimetti F. .....................................................21<br />
Z<strong>in</strong>garo B...................................................127<br />
Zollo O.......................................................113<br />
Zorzet S..........................................88; 90; 128<br />
Zorz<strong>in</strong> L. ......................................................48<br />
Zuccato C...................................................104<br />
Zucch<strong>in</strong>i S........................................15; 37; 44<br />
Zuena A.R....................................................34<br />
Zumerle A....................................................43<br />
Zusso M. ......................................................15
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