0-TESTO COMPLETO.pdf - Fondazione Santa Lucia

Sezione III: Attività per progetti
LIST OF PARTICIPATING UNITS
U.O.1 – Fondazione Santa Lucia, Laboratorio di Neuropsichiatria, Roma –
Gianfranco Spalletta
U.O.2 – IRCCS Don Gnocchi, Milano – Margherita Alberoni
U.O.3 – IRCCS INRCA, Roma – Walter Gianni
U.O.4 – Fondazione Santa Lucia, Laboratorio di Neurologia Clinica
e Comportamentale, Roma – Luca Cravello
U.O.5 – Università degli Studi dell’Aquila, Dipartimento di Medicina Interna
e Sanità Pubblica – Domenico Passafiume
U.O.6 – IRCCS Fondazione Salvatore Maugeri, Unità Operativa di Psicologia,
Pavia – Ines Giorgi
DESCRIPTION OF THE PROJECT
What is already known on the subject
According to a four-group classification, the MCI amnestic single
domain is characterized by a selective deficit of amnesic performances,
multi-domain amnestic MCI presents memory impairment and at least one
other cognitive domain impairment, nonamnestic single domain MCI is
associated with the compromise of one nonamnestic domain, and nonamnestic
multi-domain MCI is associated with the compromise of two or
more nonamnestic cognitive domains. The hypothetic usefulness of subdividing
MCI to identify specifically the type of dementia to which the patient
will convert has partially failed. However, there is solid evidence that multidomain
MCI has the highest rate of conversion in dementia. Although there
is convergence on the description of the high risk of developing AD in subjects
with chronic depression, often associated with hippocampal atrophy,
there are also studies which clarify with sufficient reliability that other neuropsychiatric
disturbances may predict conversion to AD. Regarding the
fact that therapeutic strategies for the pathogenesis of AD have failed up till
now, and considering the high risk of patients with MCI to develop AD, a
revision of the clinical-diagnostic criteria of AD has been recently proposed.
This revision makes AD diagnosis similar to those of amnesic MCI with the
exception of biological and neuroradiological markers recognized as specific
for AD diagnostic purposes. Unfortunately, the specific neuropsychiatric
symptoms of AD were not included even in this recent diagnostic revision
proposal.
– Tabert MH, Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, Zamora D,
Goodkind M, Bell K, Stern Y, Devanand DP (2006) Arch Gen Psychiatry 63(8):916-
924.
– Fischer P, Jungwirth S, Zehetmayer S, Weissgram S, Hoenigschnabl S, Gelpi E,
Krampla W, Tragl KH (2007) Neurology 68(4):288-291.
716 2009