0-TESTO COMPLETO.pdf - Fondazione Santa Lucia

Sezione III: Attività per progetti
Program care of the Regione Lombardia. Other regions will start programs in
the territory on the basis of local circumstances.
Notably, the use of the standard ADNI protocol for the development of
SOPs and for the individual diagnostic cases is a key issue. The ADNI MR
acquisition protocol is such that the grey/white matter contrast and field inhomogeneities
are similar for all scanners, regardless of manufacturer and
model. The use of the ADNI protocol, therefore, will allow the users of the
medial temporal lobe volume SOPs to use the ADNI database as the normative
reference. This is of critical relevance as it allows to avoid collecting large
scanner specific reference datasets in each user centre, something that the
large majority of Memory Clinics would find impossible to carry out.
OUTPUT(S) OF THE PROJECT
WP1 – Document: review of current protocols for the MR-based measurement
of medial temporal (hippocampal, amygdalar, and entorhinal) atrophy (M3).
– Document: description of the normative data for hippocampal volumetry
at 1.5 and 3T in cognitively healthy older persons (M9).
– Document: Draft SOPs and QA for the measurement of medial temporal
atrophy in persons with suspected Alzheimer’s disease based on MR scans (M9).
– Document: Final version of SOPs and QA for the measurement of
medial temporal atrophy in persons with suspected Alzheimer’s disease based
on MR scans (M24).
WP2 – Document: review of current protocols for the quantitative measurement
of FDG PET uptake (M3).
– Document: description of the normative data for FDG PET uptake in
cognitively healthy older persons (M9).
– Document: Draft SOPs and QA for the measurement of FDG PET
uptake in persons with suspected Alzheimer’s disease (M9).
– Document: Final version of SOPs and QA for the measurement of FDG
PET uptake in persons with suspected Alzheimer’s disease based on MR scans
(M24).
WP3 – Document: review of current protocols for the quantitative measurement
of power/coherence based on EEG recordings (M3.)
– Report: validity study of MEG/TMS for the detection of incipient AD
(M12).
– Document: description of the normative data of EEG power/coherence
in cognitively healthy older persons (M12).
– Document: SOPs and QA for the measurement of EEG power/coherence
in persons with suspected Alzheimer’s disease (M24).
WP4 – Report: validity study of FDDNP PET for the detection of incipient AD
(M24).
Si allega il programma dettagliato dell’Unità Operativa 2 che fa capo
alla Fondazione Santa Lucia.
712 2009