0-TESTO COMPLETO.pdf - Fondazione Santa Lucia

Sezione III: Attività per progetti
and liquid-liquid extraction using Cloroform/Methanol (3/1). The analytical
performances were pursued by the use of three internal standards showing a
inter-day reproducibility within the 15% of variability and a mass accuracy
below 10 ppm of error. Clear distinction in the metabolite profiles of patients
from those of control subjects can have been obtain in preliminary PLSDA
analysis of serum samples.
All the information collected with the described technological platform
would be used to generate an intranet database combining, as well, the evidences
obtained from the other groups of this consortium. The meta-analysis
of such a library might eventually return key features of the different neurodegenerative
processes and possibly suggesting new molecular targets for drugs
development.
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632 2009