0-TESTO COMPLETO.pdf - Fondazione Santa Lucia

EC.11 – Neuroprotective strategies for multiple sclerosis
support coordination, training and result dissemination, a NeuroproMiSe
interactive web-site will be created and continuously updated (month 6 to 60).
The NeuroproMiSe partners hold all the technologies and patents relevant
to the strategies pursued in this project and all partners have freedom to
operate within the outlined project. Within the consortium, collaborations
between different groups already exist with a long history of successful cooperation.
The global knowledge and expertise of the partners in human and
animal genetics, clinical and experimental neuroimmunology, and neurobiology,
and the participation of biotechnology companies with a strong interest
in the development of anti-inflammatory and neuroprotective drugs, constitute
the ideal framework for the success of this project and will stimulate
cross-disciplinary research and training, as well as promote innovative solutions.
It is expected that with the knowledge acquired about specific genes
and pathways involved in inflammatory neurodegeneration and neuroprotection,
and with the compounds developed on the basis of this knowledge,
within the 5 years of the project candidate molecules will be made available
and proposed for subsequent clinical evaluation. Altogether, the planned
activities of the NeuroproMiSe consortium will represent a significant
advance of the state of the art. Knowledge and products generated will speed
up effective treatment of neuroimmune diseases.
GENERAL DESCRIPTION AND MILESTONES
The NeuroproMiSe Project is structured into Scientific Subprojects:
– Subproject Identification: Identification of candidate genes involved in
inflammatory neurodegeneration
Workpackages I1-I6
– Subproject Mechanisms: Analysis of key effector mechanisms of inflammatory
CNS injury
Workpackages M1-M6
– Subproject Validation: Development of new therapeutics for neuroprotection
based on targets identified and validated in animal models
Workpackages V1-V8
– Subproject Horizontal Integration: Integrated activities related to neuropathology,
genomics and proteomics studies
Workpackages H1-H2
– Subproject Training: Educational training programme and Training
workshops
Workpackages T1, T2
– Subproject Management: Scientific, administrative and business management.
Si allega il programma dettagliato dell’Unità Operativa 26 che fa
capo alla Fondazione Santa Lucia.
2009 601