0-TESTO COMPLETO.pdf - Fondazione Santa Lucia

EC.11 – Neuroprotective strategies for multiple sclerosis
Role in the Project: Myelin mutant mice; laser microdissection of fluorescently
labed neurons and glial cells; cDNA microarrays; transgenic mice.
P7b – Wekerle/ MPG (Max-Planck Institute of Neurobiology), Germany – New
partner at month 27 – Competence: Reconstitution and functional evaluation
of TCR specificities in the MS brain. Role in the Project: Laser capture
microdissection, single cell PCR analysis, CDR3 spectratyping, transfections,
T-cell stimulation assays.
P8 – Olsson/ KI (Karolinska Institute), Sweden – Competence: Genetic analysis
of MS and animal models of MS and neurodegeneration, clinical and experimental
neuroimmunology. Role in the Project: Identification of disease-relevant
genes in congenic rat strains and validation of their functional role; rat
models of EAE and neurodegeneration; functional genomics; identification of
gene polymorphisms in Swedish MS patients; high throughput SNP analysis.
P9 – Peltonen/ NPHI (National Public Health Institute), Finland – Competence:
Genetics of human diseases, molecular pathogenesis of mutated genes,
animal models. Role in the Project: Identification of gene polymorphisms in
Finnish MS patients; high throughput SNP analysis; DAP12 mutant mice;
cDNA microarray analysis; bioinformatics.
P10 – Perry/ USOU (Southampton University), United Kingdom – Competence:
Mechanisms of CNS inflammation and neurodegeneration in human
and experimental diseases, innate immunity. Role in the Project: Animal model
of Wallerian degeneration; influence of systemic infection on neurodegeneration;
microglia reactivity; inflammatory mediators in the CNS; proteomics;
bioinformatics.
P11 – Smith/ KCL (King’s College London), United Kingdom – Moved to ION
UCL/P24 at month 25 - Competence: Axonal pathology in demyelinating and
neurodegenerative CNS diseases, NO-mediated neurotoxicity. Role in the Project:
Testing of sodium channel and sodium/calcium exchanger blockers in in
vitro and semi-in vivo spinal cord preparations; electrophysiological and morphometric
studies; focal demyelinated lesions. In vivo confocal spinal cord
imaging methods in EAE.
P12 – Pfizenmaier/ USTUTT (University of Stuttgart), Germany – Competence:
TNF signaling, apoptosis, recombinant proteins, targeting. Role in the Project:
Human TNF receptor selective agonists and antagonists.
P13 – Eisel/ USGR (Groningen University), The Netherlands – Competence: TNF
signaling, neuroprotective signaling pathways, transgenic and mutant mouse
approaches. Role in the Project: Development of humanized mouse models for
TNFR subtype activation; models of brain ischemia; cultured neurons.
P14 – Probert/HPI (The Hellenic Pasteur Institute), Greece – Competence:
Cytokine signaling in neuroinflammation, transgenic mouse models of CNS
inflammation. Role in the Project: Validation of TNFR1 signaling compounds
in animal models of acute and chronic neurodegeneration; integration of data
sets from cDNA microarray analyses of different disease models and in silico
simulation of the CNS inflammatory response and disease-related pathways.
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