0-TESTO COMPLETO.pdf - Fondazione Santa Lucia

Sezione III: Attività per progetti
LIST OF PARTICIPANTS
P1 – Aloisi/ ISS (Istituto Superiore di Sanità), Italy – Competence: Glial cell
biology, chemokines, immunopathology of EAE/MS. Role in the Project: EAE
models with CNS ectopic lymphoid tissue; lentivirus-mediated CNS expression
of cytokines/chemokines regulating B cell responses; laser microdissection;
confocal microscopy; analysis of ectopic lymphoid tissue in the MS
brain; glial cell (oligodendrocytes, astrocytes, microglia) cultures for evaluation
of neuroprotective compounds; glial cell functional assays.
P2a – Bähr/ UKG-GOE – Competence: Neurodegeneration, apoptosis, intracellular
signaling pathways. Role in the Project: Animal model of MS with optic
nerve degeneration; analysis of apoptotic pathways in neurons; development
of anti-apoptotic therapies and HIVTAT- fusion proteins; functional evaluation
(evoked potentials) and MRI assessment of therapeutic strategies.
P2b – Brück/ UKG-GOE – Competence: Neuropathology of MS/EAE, MS brain
biopsies. Role in the Project: Validation of gene polymorphisms in MS brain
tissue; neuropathological analysis of animal models; organization of the Neuropathology
Reference Center.
P3 (P8b starting from month 25) – Holmdahl/ ULUND (Lund University),
Sweden – Competence: Genetic analysis of animal models of MS, positional
cloning of disease relevant genes, functional analysis of candidate genes. Role
in the Project: Identification of disease-relevant genes in congenic mouse
strains and validation of their functional role; EAE models; functional
genomics; bioinformatics; mutated and transgenic mice; ex-vivo immunological
studies.
P4 – Fugger (Frise)/ MRC (Medical Research Council), United Kingdom –
Competence: Genetics of MS, MHC genes, humanized animal models. Role in
the Project: Validation of the human polymorphisms (e.g. MHC, CIITA) in animal
models; role of MHC class I and class II molecules in CNS autoimmunity;
generation of humanized animal models expressing MS-relevant MHC class I
and class II molecules and T-cell receptors.
P5 – Lassmann/ MUW (Medical University of Vienna), Austria – Competence:
Neuropathology of MS, EAE and other neurodegenerative diseases. Role in
the Project: Validation of candidate genes in pathological brain samples; neuropathological
analysis of animal models; organization of the Neuropathology
Reference Center.
P6 – Liblau-Saoudi/ INSERM (Institut National de la Santé Et de la
Recherche Médicale), France – Competence: Clinical and experimental neuroimmunology,
humanized animal models. Role in the Project: Development
of animal models (including humanized animal models) to study the pathogenic
role of encephalitogenic CD8+ T cells and evaluation of neuroprotective
compounds; immunological studies; genotyping; analysis of Treg function.
P7a – Nave/ MPG (Max-Planck Institute of Experimental Medicine), Germany
– Competence: Myelin and oligodendrocyte biology, demyelinating diseases.
594 2009