x v e l i s m a r T v a
x v e l i s m a r T v a
x v e l i s m a r T v a
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Mometasone furoate 200 _ 400 > 400 _ 800 > 800 - 1200<br />
Triamcilone<br />
acetonide<br />
400 _ 1000 > 1000 _ 2000 > 2000<br />
sainhalacio k.s.-is efeqturoba da usafrTxoeba mniSvnelovnadaa<br />
damokidebuli preparatis 2 Tvisebaze: 1.<br />
Sesabamisi receptoris mimarT afinuroba (rac maRalia<br />
afinuroba, miT maRalia receptorTan kavSiris unari<br />
da Sesabamisad Terapiuli efeqti) da 2. preparatis bioSeRwevadoba<br />
(rac dabalia bioSeRwevadoba, miT naklebia<br />
sistemuri zemoqmedebis ganviTarebis safrTxe).<br />
am mxriv mniSvnelovania flutikazoni (savaWro dasaxeleba<br />
_ fliqsotidi) da budesonidi (savaWro dasaxelreba<br />
_ pulmikorti).<br />
aseve Zalian sayuradReboa am preparatebis kombinacia<br />
gaxangrZlivebuli moqmedebis b-2 agonistebTan,<br />
rogorebicaa flutikazonisa da salmeterolis kombinacia<br />
(savaWro dasaxeleba _ seretidi multidiski) da<br />
budesonidisa da formoterolis kombinacia (savaWro<br />
dasaxeleba _ simbikorti).<br />
leikotrienebis modifikatorebi.<br />
leikotrienebi warmoadgenen mZlavr anTebiT mediatorebs,<br />
romlebic gamonTavisufldebian sxvadasxva ujredebidan.<br />
maT Soris eozinofilebidan. isini ukavSirdebian<br />
lorwovani garsSi arsebul specifiur receptorebs<br />
(LTR) da iwveveb anTebiT reaqcias da bronqospazms. leikotrienebis<br />
proanTebiTi efeqti 1000-jer swrafad vi-<br />
Tardeba vidre histaminis analogiuri efeqti.<br />
dReisaTvis arsebuli preparatebi, romlebic leikotrienebis<br />
modifikaciasa da Sesabamisad maT efeqts aferxeben,<br />
or jgufad iyofian:<br />
1. leikotrienebis receptorTa antagonistebi(LTRA).<br />
2. leikotrienebis sinTezis blokatorebi.<br />
pirvel jgufs ganekuTvneba zafirlukasti (savaWro<br />
dasaxeleba _ akolati) da montelukasti (savaWro dasaxeleba<br />
_ luqsati, vanseari, akretani, singulari).<br />
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