samwvera nervis nevralgiis mkurnaloba: karbamazepini ... - GPC
samwvera nervis nevralgiis mkurnaloba: karbamazepini ... - GPC
samwvera nervis nevralgiis mkurnaloba: karbamazepini ... - GPC
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
SedarebiT iSviaTad aRiniSneba araprogresuli an talRiseburad mimidinare<br />
asimptomuri leikopenia, rac ar qmnis mkurnalobis Sewyvetis aucileblobas. magram<br />
progresuli leikopeniis an klinikuri gamovlinebebis TandarTvis SemTxvevaSi<br />
(rogoricaa cxeleba, angina) <strong>mkurnaloba</strong> dauyovnebliv unda Sewydes.<br />
pacientma aucileblad unda Seatyobinos mkurnal eqims arasasurveli<br />
hemotologiuri (rogoricaa: cxeleba, angina, piridan sisxldena) da hepatitTan<br />
dakavSirebuli (Zilianoba, umadoba, gulisreva, siyviTle) simptomebis ganviTarebis<br />
Sesaxeb.<br />
pacientebi, romelTac aReniSnebaT <strong>karbamazepini</strong>s gamoyenebis periodSi Zilianoba da<br />
Tavbrusxveva, unda gafrTxilebuli iyvenen imis Sesaxeb rom arsebobs riski<br />
avtomobilis marTvisa da teqnikur mowyobilobebTan muSaobis dros, agreTve iseTi<br />
saqmianobis dros, romelic moiTxovs yuradRebis koncentrirebasa da normaluri<br />
refleqsebis arsebobas.<br />
anamnezSi hematologiuri gverdiTi efeqtebis SemTxvevaSi <strong>karbamazepini</strong>T mkurnalobis<br />
periodSi arsebobs hemotologiuri simptomebis gauaresebis riski. <strong>karbamazepini</strong>s<br />
zomieri antiqolinergiuli aqtivobis gamo saWiroa gansakuTrebuli sifrTxile<br />
maRali TvalSida wnevis mqone pacientebSi, amitom aRniSnuli pacientebi<br />
eqvemdebarebian mkacr samedicino monitorings.<br />
sxva triciklur warmoebulebTan urTierTqmedebis gamo <strong>karbamazepini</strong>s daniSvnam<br />
SeiZleba gamoiwvios gviani fsiqozis gaaqtiveba, da xanSiSesul pacientebSi ki<br />
SfoTva da mentaluri konfuzia (deriliumi).<br />
im SemTxvevaSi, rodesac arsebobs <strong>karbamazepini</strong>s mkurnalobis Sewyvetis<br />
aucilebloba, sxva antiepileptiur saSualebaze gadasvla unda moxdes diazepamis<br />
fonze.<br />
sxva medikamentebTan urTierTqmedeba da urTierTqmedebis sxva formebi<br />
<strong>karbamazepini</strong> metabolizdeba RviZlis citoqromebis mier (P450, kerzod ki P45003A4).<br />
is medikamentebi romlebic axdenen enzimebis metabolizmis stimulacias an<br />
inhibirebas karbamazepinTan erTdrouli gamoyenebis dros SesaZloa gamoiwvion<br />
karbmazepinis plazmis donis cvlileba, riTac izrdeba gverdiTi movlenebis<br />
ganviTarebi riski.<br />
<strong>karbamazepini</strong>s plazmis doneze moqmedi agentebi<br />
CYP 3A4-is inhibitorebi axdenen <strong>karbamazepini</strong>s metabolizmis daTrgunvas, es ki<br />
saboloo jamSi iwvevs <strong>karbamazepini</strong>s plazmis donis Semcirebas. medikamantebi,<br />
romlebic iwvevn <strong>karbamazepini</strong>s donis momatebas sisxlis plazmaSi:<br />
cimetidini, danazoli, dilTiazemi, makrolidebi, eriTromicini, troleandomicini,<br />
klariTromicini, fluoqsetini, loratadini, terfenadini, isoniazidi, niacinamidi,<br />
nikotinamidi, propoqsipeni, ketakonazoli, itrakonazoli, valproati.<br />
medikamentebi, romlebic iwveven <strong>karbamazepini</strong>s metabolizmis gaZlierebas<br />
CYP 3A4-is induqtorebi zrdian <strong>karbamazepini</strong>s metabolizmis siCqares:<br />
cisplatini, doqsorubicini, rifampini, fenobarbitali, fenitoini, primidoni,<br />
Teofilini.<br />
<strong>karbamazepini</strong> Tavismxriv iwvevs Semdegi preparatebis plazmuri donis Semcirebas:<br />
paracetamoli: hepatotoqsiurobis riski<br />
aminofilini, Terofilini – karbamazepinTan erTdrouli gamoyenebis dros SesaZloa<br />
gamoiwvion RviZlSi qsantinebis metabolizmis gaZliereba.<br />
kumarinisa da indadionis warmoebuli antikoagulantebi – antikoagulanturi efeqti<br />
SesaZloa daqveiTdes RviZlis inducirebis gamo:
Change language