Sistemi transdermici e sviluppi

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Permeabilità cutanea in vitro Linee guida OECD • OECD Guideline for the Testing of Chemicals. Skin absorption: in vitro method • (Guideline 428, April 2004). • Skin preparation • 11. Skin from human or animal sources can be used. It is recognised that the use of human skin is subject to national and international ethical considerations and conditions. Although viable skin is preferred, non-viable skin can also be used provided that the integrity of the skin can be demonstrated. Either epidermal membranes (enzymically, heat or chemically separated) or split thickness skin (typically 200-400 μm thick) prepared with a dermatome, are acceptable. Full thickness skin may be used but excessive thickness (ca. > 1 mm) should be avoided unless specifically required for determination of the test chemical in layers of the skin. The selection of species, anatomical site and preparative technique must be justified. Acceptable data from a minimum of four replicates per test preparation are required.
Permeabilità cutanea in vitro Linee guida EC Linee guida EC • Opinion on BASIC CRITERIA FOR THE IN VITRO ASSESSMENT OF DERMAL ABSORPTION OF COSMETIC INGREDIENTS - updated March 2006 (Scientific Committee On Consumer Products (SCCP), SCCP/0970/06) • EUROPEAN COMMISSION • HEALTH & CONSUMER PROTECTION DIRECTORATE- GENERAL Directorate C - Public Health and Risk Assessment C7 - Risk assessment
Page 1 and 2: Prof.ssa Paola Minghetti SISTEMI TR
Page 3 and 4: Milestones nello sviluppo dei cerot
Page 6 and 7: Classificazione (FUI XII ed.) • C
Page 8 and 9: Transdermal Systems (USP32-NF27 S1)
Page 10 and 11: Classificazione (Eur. Ph. 6.7) •
Page 12 and 13: Semisolid preparations for cutaneou
Page 14 and 15: Somministrazione transdermica Razio
Page 16 and 17: Biodisponibilità della nitroglicer
Page 18 and 19: Somministrazione transdermica Razio
Page 20 and 21: Case history: estradiolo C m,cpr: 4
Page 22 and 23: Razionale industriale • Prolungam
Page 24 and 25: Somministrazione regionale Razional
Page 26 and 27: Case history: acido flufenamico ORA
Page 28 and 29: Fasi di sviluppo di un cerotto (tra
Page 30 and 31: Fattibilità Permeabilità cutanea
Page 34 and 35: Permeabilità cuteanea in vitro Bas
Page 36 and 37: Permeabilità cuteanea in vitro Sel
Page 38 and 39: Fasi di sviluppo di un cerotto (tra
Page 40 and 41: Cerotti transdermici Sistemi “res
Page 42 and 43: Ibuprofen amount permeated mg/cm (
Page 44 and 45: amount permeated (mg/cm 2 ) Scelta
Page 46 and 47: Scelta del supporto Tipo di cerotto
Page 48 and 49: Scelta della matrice e del supporto
Page 50 and 51: Definizione delle specifiche di pro
Page 56 and 57: Segnalazioni ricevute da FDA riguar
Page 64 and 65: μg/cm2 2 coumarin pemeated in vitr
Page 66 and 67: Cerotti in commercio contenenti nit
Page 68: Prestazioni di diversi cerotti cont

Sistemi transdermici e sviluppi

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