Address: Scuola Superiore Sant'Anna, c/o IFC-CNR, Via G. Moruzzi ...

CURRICULUM VITAE VINCENZO
LIONETTI M.D., Ph.D.
Address: Scuola Superiore Sant'Anna, c/o IFC-CNR, Via G. Moruzzi n°1/56124 Pisa, Italy
E-mail: enzolionetti@hotmail.com; v.lionetti@sssup.it
Telephone: +39-050-3152216/2026
Date of birth: 10/28/1973
Place of birth: Canosa di Puglia (Ba), Italy
Citizenship: Italian
Marital status: Married
Professional interests: Heart failure pathophysiology and innovative therapies.
Current position: Assistant Professor of Physiology, Sector of Medicine, Scuola Superiore Sant’Anna, Pisa, Italy.
Scientific Topic: Physiology and pathophysiology of regional myocardial repair in heart failure.
Education
1999 M. D. Thesis, Faculty of Medicine, University of Bari, Italy. 110/110
2000 Abilitation for medical practice, University of Bari, Italy.
Dec ’01/ Jan’03 Pre-Doctoral Fellowship in Physiology, Department of Physiology, BSB, New York
Medical College, Valhalla, USA.
Dec ’03 Residency in Anesthesiology and Intensive Care Medicine, Department of Anesthesiology and Intensive
Care Medicine, University of Turin, Italy. 70 cum laude.
Dec ’07 Ph.D Thesis in Innovative Strategies in Biomedical Research, Sector of Medicine, Scuola Superiore
Sant’Anna, Pisa, Italy.
Professional Experiences
Jan’ 98- Dec ’00 Internship, Department of Pharmacology and Human Physiology, Faculty of Medicine,
University of Bari, Italy.
Jan' 03-Dec' 03 Internship, Department of Genetics, Biology and Biochemistry, Faculty of Medicine,
University of Turin, Italy.
Feb ’05-Feb ‘06 Medical Consultant, Department of Intensive Care Medicine, Faculty of Medicine,
University of Pisa, Italy
Jan’07 – Aug ’08, Grant Researcher in Physiology, Sector of Medicine, Scuola Superiore Sant’Anna,
Pisa, Italy.
Jan’07-Dec’07 Scientific Consultant, Prassis, Institute of Research Sigma-Tau, Settimo Milanese,
Milan, Italy.
Sep’ 08-current Assistant Professor of Physiology, Sector of Medicine, Scuola Superiore Sant’Anna, Pisa,
Italy.
Jan ’09- current Head, Unit of Translational Medicine, National Institute of Biostructures and
Biosystems, Bologna, Italy.
Jan ’10-current Physician, Fondazione G. Monastero Regione Toscana-CNR, Pisa, Italy
Apr ’10-current Associate Assistant Professor of Physiology, Institute of Clinical Physiology, National
Council of Research, Pisa, Italy.
Publications
(* equally contributed)
1. Lionetti V, Recchia FA. New therapies for the failing heart: trans-genes versus trans-cells. Transl Res. 2010
Sep;156(3):130-135.
2. Del Ry S, Cabiati M, Lionetti V, Giannessi D. NPR-B, the C-type natriuretic peptide specific receptor, is the
predominant biological receptor in mouse and pig myocardial tissue. Minerva Endocrinol. 2010 Jun;35(2):37-
46.
3. Lionetti V, Bianchi G, Recchia FA, Ventura C. Control of autocrine and paracrine myocardial signals: an
emerging therapeutic strategy in heart failure. Heart Fail Rev. 2010 Apr 3. [Epub ahead of print].
4. Gemignani V, Bianchini E, Faita F, Lionetti V, Campan M, Recchia FA, Picano E, Bombardini T.
Transthoracic sensor for noninvasive assessment of left ventricular contractility: validation in a minipig
model of chronic heart failure. Pacing Clin Electrophysiol. 2010 Jul;33(7):795-803.

5. Forini F*, Lionetti V*, Ardehali H, Pucci A, Cecchetti F, Ghanefar M, Nicolini G, Ichikawa Y, Nannipieri M,
Recchia FA, Iervasi G. Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac
remodeling in rats. J Cell Mol Med. 2010 Jan 20. [Epub ahead of print].
6. Lionetti V*, Cantoni S*, Cavallini C, Bianchi F, Valente S, Frascari I, Olivi E, Aquaro GD, Bonavita F,
Scarlata I, Maioli M, Vaccari V, Tassinari R, Bartoli A, Recchia FA, Pasquinelli G, Ventura C. Hyaluronan
mixed esters of butyric and retinoic acid affording myocardial survival and repair without stem cell
transplantation. J Biol Chem. 2010 Mar 26;285(13):9949-61.
7. Zentilin L*, Puligadda U*, Lionetti V*, Zacchigna S, Collesi C, Pattarini L, Ruozi G, Camporesi S, Sinagra
G, Pepe M, Recchia FA, Giacca M. Cardiomyocyte VEGFR-1 activation by VEGF-B induces compensatory
hypertrophy and preserves cardiac function after myocardial infarction. FASEB J. 2010 May;24(5):1467-78.
8. Lionetti V*, Aquaro GD*, Simioniuc A, Di Cristofano C, Forini F, Cecchetti F, Campan M, De Marchi D,
Bernini F, Grana M, Nannipieri M, Mancini M, Lombardi M, Recchia FA, Pingitore A. Severe mechanical
dyssynchrony causes regional hibernation-like changes in pigs with nonischemic heart failure. J Card Fail.
2009 Dec;15(10):920-8.
9. Del Ry S, Cabiati M, Lionetti V, Simioniuc A, Caselli C, Prescimone T, Emdin M, Giannessi D.
Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure. Peptides. 2009
Sep;30(9):1710-3.
10. Lionetti V, Fittipaldi A, Agostini S, Giacca M, Recchia FA, Picano E. Enhanced caveolae-mediated
endocytosis by diagnostic ultrasound in vitro. Ultrasound Med Biol. 2009 Jan;35(1):136-43.
11. Del Ry S, Cabiati M, Lionetti V, Emdin M, Recchia FA, Giannessi D. Expression of C-type natriuretic
peptide and of its receptor NPR-B in normal and failing heart. Peptides. 2008 Dec;29(12):2208-15.
12. Valdastri P, Rossi S, Menciassi A, Lionetti V, Bernini F, Recchia FA, Dario P. An implantable ZigBee ready
telemetric platform for in vivo monitoring of physiological parameters. Sensors and Actuators A: Physical.
2008;142(1): 369-378.
13. Lionetti V. Coronary microvascular function and myocardial metabolism in the pig model of pacing induced
progressive LV dysfunction. Biomedicine and pharmacotherapy. 2008;62(8):508.
14. Gargani L*, Lionetti V*, Di Cristofano C, Bevilacqua G, Recchia FA, Picano E. Early detection of acute lung
injury uncoupled to hypoxemia in pigs using ultrasound lung comets. Crit Care Med. 2007 Dec;35(12):2769-
74. With Editorial.
15. Lionetti V, Guiducci L, Simioniuc A, Aquaro GD, Simi C, De Marchi D, Burchielli S, Pratali L, Piacenti M,
Lombardi M, Salvadori P, Pingitore A, Neglia D, Recchia FA. Mismatch between uniform increase in cardiac
glucose uptake and regional contractile dysfunction in pacing-induced heart failure. Am J Physiol Heart Circ
Physiol. 2007 Nov;293(5):H2747-56.
16. Recchia FA, Lionetti V. Animal models of dilated cardiomyopathy for translational research. Vet Res
Commun. 2007 Aug;31 Suppl 1:35-41.
17. Del Ry S, Cabiati M, Lionetti V, Colotti C, Maltinti M, Emdin M, Recchia FA, Giannessi D. Sequencing and
cardiac expression of natriuretic peptide receptor 2 (NPR-B) in Sus Scrofa. Peptides. 2007 Jul;28(7):1390-6.
18. Ventura C, Cantoni S, Bianchi F, Lionetti V, Cavallini C, Scarlata I, Foroni L, Maioli M, Bonsi L, Alviano F,
Fossati V, Bagnara GP, Pasquinelli G, Recchia FA, Perbellini A. Hyaluronan mixed esters of butyric and
retinoic Acid drive cardiac and endothelial fate in term placenta human mesenchymal stem cells and enhance
cardiac repair in infarcted rat hearts. J Biol Chem. 2007 May 11;282(19):14243-52.
19. Labinskyy V, Bellomo M, Chandler MP, Young ME, Lionetti V, Qanud K, Bigazzi F, Sampietro T, Stanley
WC, Recchia FA. Chronic activation of peroxisome proliferator-activated receptor-alpha with fenofibrate
prevents alterations in cardiac metabolic phenotype without changing the onset of decompensation in pacinginduced
heart failure. J Pharmacol Exp Ther. 2007 Apr;321(1):165-71.
20. Gupte SA, Levine RJ, Gupte RS, Young ME, Lionetti V, Labinskyy V, Floyd BC, Ojaimi C, Bellomo M,
Wolin MS, Recchia FA. Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in
the failing heart. J Mol Cell Cardiol. 2006 Aug;41(2):340-9.
21. d'Agostino C, Labinskyy V, Lionetti V, Chandler MP, Lei B, Matsuo K, Bellomo M, Xu X, Hintze TH,
Stanley WC, Recchia FA. Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in
chronically instrumented dogs. Am J Physiol Heart Circ Physiol. 2006 Apr;290(4):H1721-6.
22. Lionetti V, Lisi A, Patrucco E, De Giuli P, Milazzo MG, Ceci S, Wymann M, Lena A, Gremigni V, Fanelli V,
Hirsch E, Ranieri VM. Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury.
Crit Care Med. 2006 Jan;34(1):134-41. With Editorial.
23. Lionetti V, Linke A, Chandler MP, Young ME, Penn MS, Gupte S, d'Agostino C, Hintze TH, Stanley WC,
Recchia FA. Carnitine palmitoyl transferase-I inhibition prevents ventricular remodeling and delays
decompensation in pacing-induced heart failure. Cardiovasc Res. 2005 Jun 1;66(3):454-61. With Editorial.

24. Lionetti V, Recchia FA, Ranieri VM. Overview of ventilator-induced lung injury mechanisms. Curr Opin Crit
Care. 2005 Feb;11(1):82-6.
25. Lei B, Lionetti V, Young ME, Chandler MP, d'Agostino C, Kang E, Altarejos M, Matsuo K, Hintze TH,
Stanley WC, Recchia FA. Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux
in severe heart failure. J Mol Cell Cardiol. 2004 Apr;36(4):567-76.
26. Post H, d'Agostino C, Lionetti V, Castellari M, Kang EY, Altarejos M, Xu X, Hintze TH, Recchia FA.
Reduced left ventricular compliance and mechanical efficiency after prolonged inhibition of NO synthesis in
conscious dogs. J Physiol. 2003 Oct 1;552(Pt 1):233-9.
Book chapters
1. Lionetti V, Pingitore A. In Vivo Imaging of Regenerated Tissue: State of Art and Future Perspectives. In:
Alfonso Barbarisi, Paolo Bechi, Paolo Innocenti, Carlo A. Redi, Francesco Rosso (Eds.): Biotechnology in
Surgery (Updates in Surgery). 2010, In Press. Springer Edition.
2. Lionetti V. Local Gene Delivery for Tissue Repair in Surgery. In: Alfonso Barbarisi, Paolo Bechi, Paolo
Innocenti, Carlo A. Redi, Francesco Rosso (Eds.): Biotechnology in Surgery (Updates in Surgery). 2010, In
Press. Springer Edition.
3. Lionetti V, Paddeu S. Towards ultrasound molecular imaging. In: Gaio Paradossi, Paolo Pellegretti, Andrea
Trucco (Eds.): Ultrasound Contrast Agents: Targeting and Processing Methods for Theranostics. 2010, 1-11 p.
Springer-Verlag, Milan.
4. Pingitore A, Lionetti V, Forini F. Synthetic Thyroid Hormone and Thyroid Hormon Analogues for
Treatment of Heart Failure. In: Giorgio Iervasi, Alessandro Pingitore (Eds.):Thyroid and Heart Failure
From Pathophysiology to Clinics. 2009, XXII, 266 p. Springer Edition.
5. Lionetti V and Ranieri VM. Role of G-proteins in VILI. In: Jean-Louis Vincent (Eds): Yearbook of
Intensive Care and Emergency Medicine. 2004, XXVIII, 915 p. 194 illus. Springer Edition.
Professional Organization, Society and Group of Study
• Premium Professional Member of the American Heart Association (USA).
• Member of Council on Basic Cardiovascular Science, American Heart Association (USA).
• Mentee of the International Mentoring Program of the American Heart Association.
Mentor: Dr. Hossein Ardehali, Feinberg Cardiovascular Institute, Northwestern University,
Chicago, USA.
• Member of the Heart Failure Association of the European Society of Cardiology.
• Member of the Society of Experimental Biology and Medicine (USA).
• Member of the Steering Committee of the Group of Study on Cardiac Cell and Molecular
Biology, Italian Society of Cardiology.
• Member of the Italian Society of Cardiology.
• Member of the Italian Society of Physiology.
• Member of National Institute of Biostructures and Biosystems (ITALY).
Awards and Grants
• 2009 Young Investigator Award, Istituto Nazionale per le Ricerche Cardiovascolari, Bologna,
Italy
• 2008 Grant for Young Investigators, National Health Service, Italy.
• 2008 “Fondazione Giovanni Spitali” Award, Scuola Superiore Sant’Anna, Pisa, Italy.
• 2007 PRIN Grant, MIUR, Italy.
• 2007 Heart Failure Association Travel Grant, Heart Failure Association of the European Society
of Cardiology.
• 2007 American Heart Association Travel Grant, AHA Scientific Session 2007.
• 2006 “Alberto Barlettani” Award, Rotary Club and Lions Club, Cecina-Rosignano
(Livorno), Italy.
• 2003 Mention of Honor , Department of Critical care Medicine, School of Medicine,
University of Turin,Turin, Italy.
• 2002 Council On Basic Cardiovascular Sciences, Trainee Abstract Award, American Heart
Association.

Editorial Activities
- Associate Faculty Member, Physiology, Faculty of 1000 Biology. (2010-current)
- Member of the Editorial Board of the Journal of Stem Cell Research & Therapy (2010-current)
- Reviewer for the following scientific journals:
• Evidence-based Complementary and Alternative Medicine, Clinical Journal of the American Society
of Nephrology (2010-current)
• Cardiovascular Research, Ultrasound in Medicine and Biology, Journal of Cellular and Molecular
Cardiology (2007- current)
• American Journal of Critical Care Medicine (2005-2006)