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Progetto Laser, lotta alla sepsi in Emilia-Romagna - apicella

Progetto Laser, lotta alla sepsi in Emilia-Romagna - apicella

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Prote<strong>in</strong>a C attivata<br />

Strategia di ricerca PubMed<br />

<strong>Progetto</strong> LaSER. Lotta <strong>alla</strong> <strong>sepsi</strong> <strong>in</strong> <strong>Emilia</strong>-<strong>Romagna</strong><br />

Allegati<br />

(<strong>sepsi</strong>s[text] OR “septic shock”[text]) AND (“drotrecog<strong>in</strong> alfa activated”[Substance Name]<br />

OR “Prote<strong>in</strong> C”[MeSH]) AND (“controlled cl<strong>in</strong>ical trial”[Publication Type] OR “randomized<br />

controlled trial”[Publication Type]) AND (“2004/01/01”[PDAT] : “2006/06/01”[PDAT])<br />

AND hasabstract[text]<br />

Risultati della ricerca PubMed<br />

• Abraham E., Laterre P.F., Garg R., Levy H., Talwar D., Trzaskoma B.L., Francois B., Guy<br />

J.S., Bruckmann M., Rea-Neto A., Rossa<strong>in</strong>t R., Perrot<strong>in</strong> D., Sablotzki A., Ark<strong>in</strong>s N.,<br />

Utterback B.G., Macias W.L., Adm<strong>in</strong>istration of Drotrecog<strong>in</strong> Alfa (Activated) <strong>in</strong> Early Stage<br />

Severe Sepsis (ADDRESS) Study Group. Drotrecog<strong>in</strong> alfa (activated) for adults with<br />

severe <strong>sepsi</strong>s and a low risk of death. N Engl J Med, 353 (13): 1332-1341, 29 Sep 2005.<br />

• Barton P., Kalil A.C., Nadel S., Goldste<strong>in</strong> B., Okhuysen-Cawley R., Brilli R.J., Takano<br />

J.S., Mart<strong>in</strong> L.D., Qu<strong>in</strong>t P., Yeh T.S., Dalton H.J., Gessouron M.R., Brown K.E., Betts H.,<br />

Lev<strong>in</strong> M., Macias W.L., Small D.S., Wyss V.L., Bates B.M., Utterback B.G., Giroir B.P.<br />

Safety, pharmacok<strong>in</strong>etics, and pharmacodynamics of drotrecog<strong>in</strong> alfa (activated) <strong>in</strong><br />

children with severe <strong>sepsi</strong>s. Pediatrics, 113 (1 Pt 1): 7-17, 2004. PMID: 14702440<br />

[PubMed - <strong>in</strong>dexed for MEDLINE]<br />

• Bernard G.R., Margolis B.D., Shanies H.M., Ely E.W., Wheeler A.P., Levy H., Wong K.,<br />

Wright T.J., Extended Evaluation of Recomb<strong>in</strong>ant Human Activated Prote<strong>in</strong> C United<br />

States Investigators. Extended evaluation of recomb<strong>in</strong>ant human activated prote<strong>in</strong> C<br />

United States Trial (ENHANCE US): a s<strong>in</strong>gle-arm, phase 3B, multicenter study of<br />

drotrecog<strong>in</strong> alfa (activated) <strong>in</strong> severe <strong>sepsi</strong>s. Chest, 125 (6): 2206-2216, 2004. PMID:<br />

15189943 [PubMed - <strong>in</strong>dexed for MEDLINE]<br />

• Friedrich J.O. Drotrecog<strong>in</strong> alfa (activated) <strong>in</strong> severe <strong>sepsi</strong>s. N Engl J Med, 354: 94-96,<br />

2006. PMID: 16394311 [PubMed - <strong>in</strong>dexed for MEDLINE]<br />

• Fry D.E., Beilman G., Johnson S., Williams M.D., Rodman G., Booth F.V., Bates B.M.,<br />

McCollam J.S., Lowry S.F., PROWESS Surgical Evaluation Committee. Safety of<br />

drotrecog<strong>in</strong> alfa (activated) <strong>in</strong> surgical patients with severe <strong>sepsi</strong>s. Surg Infect (Larchmt),<br />

5 (3): 253-259, Fall 2004. PMID: 15684796 [PubMed - <strong>in</strong>dexed for MEDLINE]<br />

• Green C., D<strong>in</strong>nes J., Takeda A., Shepherd J., Hartwell D., Cave C., Payne E.,<br />

Cuthbertson B.H. Cl<strong>in</strong>ical effectiveness and cost-effectiveness of drotrecog<strong>in</strong> alfa<br />

(activated) (Xigris) for the treatment of severe <strong>sepsi</strong>s <strong>in</strong> adults: a systematic review and<br />

economic evaluation. Health Technol Assess, 9 (11): 1-126, iii-iv, Mar 2005. PMID:<br />

15774234 [PubMed - <strong>in</strong>dexed for MEDLINE]<br />

• Hoffmann J.N., Muhlbayer D., Jochum M., Inthorn D. Effect of long-term and high-dose<br />

antithromb<strong>in</strong> supplementation on coagulation and fibr<strong>in</strong>olysis <strong>in</strong> patients with severe<br />

<strong>sepsi</strong>s. Crit Care Med, 32 (9): 1851-1859, Sep 2004. PMID: 15343012 [PubMed - <strong>in</strong>dexed<br />

for MEDLINE]<br />

Dossier 143<br />

97

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