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Citochine Anti Infiammatorie INFIAMMAZIONE – sepsi - shock Stimolo Mediatori Stimolo SIRS Livello Normale di attività attivit immunologica CARS Iporesponsività Iporesponsivit e Immunoparalisi Pro-infiammatori Pro infiammatori Mediatori anti-infiammatori anti infiammatori Inibitori Ripristino del livello normale di innumorisposta è l’obiettivo obiettivo primario del trattamento della sepsi
IMMUNOMODULAZIONE : Il goal della MOST Rimozione non selettiva di mediatori della sepsi (pro e anti infiammatori) infiammatori) Tetta C, et al. Nephrol Nephrol Dial Dial Transplant Transplant 1998 Ronco C et al Crit Crit Care Care Med Med 2002 Kellum J Crit Crit Care Care Med Med 2002
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CORSO AVANZATO PER MEDICI Trattamen
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→ Il flusso ematico renale rappre
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Factors that render the kidney susc
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IRA: definizione L’IRA IRA è una
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Incidenza dell’IRA dell IRA (Vinc
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August 28-30, 28 30, 2000 New York
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ORIGINAL INVESTIGATIONS The Outcome
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Hospital Mortality Rate in RRT Pati
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• IRA,frequente complicanza in IC
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DIAGNOSES IN 544 PATIENTS WITH ARF
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Acute Renal Failure in critically i
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M.E. Ostermann, D. Taube, C.J. Morg
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A higher level of knowledge needs t
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Vivino G, Antonelli M, Moro ML, Cot
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Risk factors increased by • Age
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Agents and Events That Ameliorate o
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Drugs Associated with Acute Renal F
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RI=0.63 Renal Protection through st
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A.de Mendonça, J.L. Vincent, P.M.
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• Infection … they concluded th
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De Mendonça A et al. Acute renal f
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• Advanced age • Altered previo
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Quale forma di IRA è frequentement
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Sepsi: Stadi e definizioni Infezion
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Arterial Vasodilatation and Renal V
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Effect of Membrane Potential on the
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good and bad effects of nitric oxid
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FORMATION OF LPS/PROTEIN COMPLEXES
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Tubular-Cell Injury and Repair in I
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ACTIVATION OF HUMORAL PATHWAY L P S
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A disorder due to incontrolled infl
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The pathogenesis of septic acute re
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Jo e colleghi hanno recentemente di
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APOPTOSIS
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Acute renal failure Norbert Lameire
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600 500 400 300 200 100 0 PaO2/FiO2
Page 77 and 78: ml/die 8000 7000 6000 5000 4000 300
Page 79 and 80: mg/dL 700 600 500 400 300 200 100 0
Page 81 and 82: Lasciato a se stesso e non contrast
Page 83 and 84: Strategie di protezione
Page 85 and 86: SEPSI E IRA Rilascio citochine,atti
Page 87 and 88: Renal Perfusion Pressure: Pressure
Page 89 and 90: • Riempimento volemico per manten
Page 91 and 92: Acute phase: Patients who have dila
Page 93 and 94: Cardiovascular changes associated w
Page 95 and 96: Dellinger RP. Crit Care Med 2003;31
Page 97 and 98: Edema removal by a dialysis techniq
Page 100: “independent independent from an
Page 103 and 104: …..guardando gli effetti biologic
Page 105 and 106: APOPTOSIS IN SEPSIS PHVHF decreased
Page 107 and 108: Terapia anti apoptosica? The Acute
Page 109 and 110: (%) Survival Rate of Early Vs Late
Page 112 and 113: EARLY ISOVOLEMIC HAEMOFILTRATION IN
Page 114 and 115: - Trattamento extracorporeo del san
Page 116 and 117: MOST Brain Liver mRNA/NfKb Cytokine
Page 118 and 119: Early detection of ARF,especially i
Page 120 and 121: . . Grazie per l’attenzione l att
Page 122 and 123: The Response to Pathogens, Involvin
Page 125 and 126: Immunologic Response of Three Hypot
Page 127: Dal momento che la sepsi è un proc
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