Piccinni (PDF) - Fresenius Medical Care

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POTENTIAL BENEFICIAL EFFECTS OF CRRT ON THE COURSE OF SIRS / MODS • Clearance of circulating toxic substances Convective transport into ultrafiltrate Adsorption onto the membrane surface • Decreasing body core temperature in hypertermic patients Reduction oxygen demand Improved hemodynamics • Titration ventricular filling pressure • Correction of lactic acidosis hyperlactacidemia • Continuous intravascular refilling Reduction extravascular lungwater Reduction myocardial edema Improved regional tissue oxigen balance
…..guardando gli effetti biologici e soprattutto l’omeostasi del sistema immunitario, con particolare attenzione ai fenomeni apoptotici, cruciali nella propagazione e mantenimento della sepsi ,recentemente, il nostro gruppo ha osservato una significativa riduzione dei mediatori dell’apoptosi nel sangue circolante di pazienti settici trattati con HVHF rispetto ai pazienti trattati con dosi convenzionali, dimostrando perciò degli effetti biologici positivi sulla risposta immunitaria cellulare Anche il Drotrecogin alfa (attivato), tra le sue attività, ha proprietà anti-apoptotiche evidenti:sarebbe interessante combinare il suo utilizzo con l’HVHF .
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CORSO AVANZATO PER MEDICI Trattamen
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→ Il flusso ematico renale rappre
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Factors that render the kidney susc
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IRA: definizione L’IRA IRA è una
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Incidenza dell’IRA dell IRA (Vinc
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August 28-30, 28 30, 2000 New York
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ORIGINAL INVESTIGATIONS The Outcome
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Hospital Mortality Rate in RRT Pati
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• IRA,frequente complicanza in IC
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DIAGNOSES IN 544 PATIENTS WITH ARF
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Acute Renal Failure in critically i
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M.E. Ostermann, D. Taube, C.J. Morg
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A higher level of knowledge needs t
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Vivino G, Antonelli M, Moro ML, Cot
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Risk factors increased by • Age
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Agents and Events That Ameliorate o
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Drugs Associated with Acute Renal F
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RI=0.63 Renal Protection through st
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A.de Mendonça, J.L. Vincent, P.M.
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• Infection … they concluded th
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De Mendonça A et al. Acute renal f
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• Advanced age • Altered previo
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Quale forma di IRA è frequentement
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Sepsi: Stadi e definizioni Infezion
Page 50 and 51: Arterial Vasodilatation and Renal V
Page 52 and 53: Effect of Membrane Potential on the
Page 54 and 55: good and bad effects of nitric oxid
Page 56 and 57: FORMATION OF LPS/PROTEIN COMPLEXES
Page 58 and 59: Tubular-Cell Injury and Repair in I
Page 60 and 61: ACTIVATION OF HUMORAL PATHWAY L P S
Page 62 and 63: A disorder due to incontrolled infl
Page 64 and 65: The pathogenesis of septic acute re
Page 66 and 67: Jo e colleghi hanno recentemente di
Page 68 and 69: APOPTOSIS
Page 70 and 71: Acute renal failure Norbert Lameire
Page 73: 600 500 400 300 200 100 0 PaO2/FiO2
Page 77 and 78: ml/die 8000 7000 6000 5000 4000 300
Page 79 and 80: mg/dL 700 600 500 400 300 200 100 0
Page 81 and 82: Lasciato a se stesso e non contrast
Page 83 and 84: Strategie di protezione
Page 85 and 86: SEPSI E IRA Rilascio citochine,atti
Page 87 and 88: Renal Perfusion Pressure: Pressure
Page 89 and 90: • Riempimento volemico per manten
Page 91 and 92: Acute phase: Patients who have dila
Page 93 and 94: Cardiovascular changes associated w
Page 95 and 96: Dellinger RP. Crit Care Med 2003;31
Page 97 and 98: Edema removal by a dialysis techniq
Page 100: “independent independent from an
Page 105 and 106: APOPTOSIS IN SEPSIS PHVHF decreased
Page 107 and 108: Terapia anti apoptosica? The Acute
Page 109 and 110: (%) Survival Rate of Early Vs Late
Page 112 and 113: EARLY ISOVOLEMIC HAEMOFILTRATION IN
Page 114 and 115: - Trattamento extracorporeo del san
Page 116 and 117: MOST Brain Liver mRNA/NfKb Cytokine
Page 118 and 119: Early detection of ARF,especially i
Page 120 and 121: . . Grazie per l’attenzione l att
Page 122 and 123: The Response to Pathogens, Involvin
Page 125 and 126: Immunologic Response of Three Hypot
Page 127 and 128: Dal momento che la sepsi è un proc
Page 129: IMMUNOMODULAZIONE : Il goal della M
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