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Seminari di Ematologia Oncologica - Società Italiana di Ematologia

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44 <strong>Seminari</strong> <strong>di</strong> <strong>Ematologia</strong> <strong>Oncologica</strong><br />

Results of a prospective randomized study of the<br />

German Low Grade Lymphoma Study Group (GLSG).<br />

Blood. 2006; 108: 4003-8.<br />

70. Smith MR, Zhang L, Gordon LI, Foran J, Kahl B,<br />

Gascoyne RD, et al. Horning phase II study of R-<br />

CHOP followed by 90Y-Ibritumomab Tiuxetan in<br />

untreated mantle cell lymphoma: eastern cooperative<br />

oncology group study E1499 (Abstract). Blood.<br />

2007; 110: 389.<br />

71. Dreyling M, Weigert O, Hiddemann W; European MCL<br />

Network. Current treatment standards and future<br />

strategies in mantle cell lymphoma. Ann Oncol.<br />

2008;19: iv41-4.<br />

72. Khouri IF, Lee MS, Saliba RM, Jun G, Fayad L, Younes<br />

A, et al. Nonablative allogeneic stem-cell transplantation<br />

for advanced/recurrent mantle-cell lymphoma.<br />

J Clin Oncol. 2003; 21: 4407-12.<br />

73. Tam CS, Bassett R, Ledesma C, Korbling M, Alousi<br />

A, Hosing C, et al. Mature results of the M. D.<br />

Anderson Cancer Center risk-adapted transplantation<br />

strategy in mantle cell lymphoma. Blood. 2009; 113:<br />

4144-52.<br />

74. Rummel MJ, Al-Batran SE, Kim SZ, Welslau M, Hecker<br />

R, Kofahl-Krause D, et al. Bendamustine plus rituximab<br />

is effective and has a favorable toxicity profile in the treatment<br />

of mantle cell and low-grade non-Hodgkin’s lymphoma.<br />

J Clin Oncol. 2005; 23: 3383-9.<br />

75. Rodríguez J, Gutierrez A, Palacios A, Navarrete M,<br />

Blancas I, Alarcón J, et al. Rituximab, gemcitabine and<br />

oxaliplatin: an effective regimen in patients with refractory<br />

and relapsing mantle cell lymphoma. Leuk<br />

Lymphoma. 2007; 48: 2172-8.<br />

76. Wang M, Oki Y, Pro B, Romaguera JE, Rodriguez MA,<br />

Samaniego F, et al. Phase II study of yttrium-90-ibritumomab<br />

tiuxetan in patients with relapsed or refractory<br />

mantle cell lymphoma. J Clin Oncol. 2009; 27:<br />

5213-8.<br />

77. Pérez-Galán P, Dreyling M, Wiestner A. Mantle cell<br />

lymphoma: biology, pathogenesis, and the molecular<br />

basis of treatment in the genomic era. Blood. 2011;<br />

117: 26-38.<br />

78. Fisher RI, Bernstein SH, Kahl BS, Djulbegovic B,<br />

Robertson MJ, de Vos S, et al. Multicenter phase II<br />

study of bortezomib in patients with relapsed or<br />

refractory mantle cell lymphoma. J Clin Oncol. 2006;<br />

24: 4867-74.<br />

79. Martínez N, Camacho FI, Algara P, Rodríguez A,<br />

Dopazo A, Ruíz-Ballesteros E, et al. The molecular<br />

signature of mantle cell lymphoma reveals multiple<br />

signals favoring cell survival. Cancer Res. 2003; 63:<br />

8226-32.<br />

80. Weigert O, Pastore A, Rieken M, Lang N, Hiddemann<br />

W, Dreyling M. Sequence-dependent synergy of the<br />

proteasome inhibitor bortezomib and cytarabine in<br />

mantle cell lymphoma. Leukemia. 2007; 21: 524-8.<br />

81. Weigert O, Unterhalt M, Hiddemann W, Dreyling M.<br />

Mantle cell lymphoma: state-of-the-art management<br />

and future perspective. Leuk Lymphoma. 2009; 50:<br />

1937-50.<br />

82. Ruan J, Martin P, Furman RR, Lee SM, Cheung K,<br />

Vose JM, et al. Bortezomib Plus CHOP-Rituximab for<br />

Previously Untreated Diffuse Large B-Cell Lymphoma<br />

and Mantle Cell Lymphoma. J Clin Oncol. 2010 Dec<br />

28. (Epub ahead of print).<br />

83. Kaufmann H, Raderer M, Wöhrer S, Püspök A, Bankier<br />

A, Zielinski C, et al. Antitumor activity of rituximab plus<br />

thalidomide in patients with relapsed/refractory mantle<br />

cell lymphoma. Blood. 2004; 104: 2269-71.<br />

84. Habermann TM, Lossos IS, Justice G, Vose JM,<br />

Wiernik PH, McBride K, et al. Lenalidomide oral<br />

monotherapy produces a high response rate in<br />

patients with relapsed or refractory mantle cell lymphoma.<br />

Br J Haematol. 2009; 145: 344-9.<br />

85. Zinzani PL, Witzig TE, Vose JM, Reeder CB, Buckstein<br />

R, Haioun C, et al. Confirmation of the efficacy and<br />

safety of Lenalidomide oral monotherapy in patients<br />

with relapsed or refractory mantle-cell lymphoma:<br />

results of an International study (NHL-003) [Abstract].<br />

Blood. Nov 2008; 112: 262.<br />

86. Witzig TE, Geyer SM, Ghobrial I, Inwards DJ,<br />

Fonseca R, Kurtin P, et al. Phase II trial of single-agent<br />

temsirolimus (CCI-779) for relapsed mantle cell lymphoma.<br />

J Clin Oncol. 2005; 23: 5347-56.<br />

87. Hess G, Herbrecht R, Romaguera J, Verhoef G,<br />

Crump M, Gisselbrecht C, et al. Phase III study to<br />

evaluate temsirolimus compared with investigator’s<br />

choice therapy for the treatment of relapsed or refractory<br />

mantle cell lymphoma. J Clin Oncol. 2009; 27:<br />

3822-9.<br />

88. Witzig TE, Reeder CB, Laplant BR, Gupta M,<br />

Johnston PB, Micallef IN, et al. A phase II trial of the<br />

oral mTOR inhibitor everolimus in relapsed aggressive<br />

lymphoma. Leukemia. 2011; 25: 341-7.<br />

89. Renner C, Zinzani PL, Gressin R, Klingbiel D, Favet<br />

L, Hitz F, et al. A multi-center phase II study (SAKK<br />

36/06) of single agent everolimus (RAD001) in<br />

patients with relapsed or refractory mantle cell lymphoma<br />

(Abstract). Blood. 2010; 116: 2803.<br />

90. Lin TS, Blum KA, Fischer DB, Mitchell SM, Ruppert<br />

AS, Porcu P, et al. Flavopiridol, fludarabine, and rituximab<br />

in mantle cell lymphoma and indolent B-cell<br />

lymphoproliferative <strong>di</strong>sorders. J Clin Oncol. 2010; 28:<br />

418-23.<br />

91. Lannutti BJ, Meadows SA, Herman SE, Kashishian A,<br />

Steiner B, Johnson AJ, et al. CAL-101, a p110{delta}<br />

selective phosphatidylinositol-3-kinase inhibitor for the<br />

treatment of B-cell malignancies, inhibits PI3K signaling<br />

and cellular viability. Blood. 2011; 117: 591-4.<br />

92. Brown J, Byrd J, Furman R, Flinn I, Benson D, Coutre<br />

D, et al. Clinical activity in a phase I study of CAL-101,<br />

an isoform-selective inhibitor of phosphatidylinositol 3-<br />

Kinase P110 delta, in patients with B-Cell malignancies<br />

(Abstract). Haematologica. 2010; 95 (Suppl. 2): 466.<br />

93. Morschhauser F, Seymour JF, Kluin-Nelemans HC,

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